|
JPS63152393A
(ja)
|
1986-07-03 |
1988-06-24 |
Takeda Chem Ind Ltd |
グリコシル誘導体
|
|
US6217857B1
(en)
|
1989-06-28 |
2001-04-17 |
Schering Corporation |
Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof
|
|
US5231012A
(en)
|
1989-06-28 |
1993-07-27 |
Schering Corporation |
Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10)
|
|
US5252714A
(en)
|
1990-11-28 |
1993-10-12 |
The University Of Alabama In Huntsville |
Preparation and use of polyethylene glycol propionaldehyde
|
|
IE68836B1
(en)
|
1991-01-16 |
1996-07-10 |
Schering Corp |
Use of interleukin-10 in adoptive immunotherapy of cancer
|
|
JP3260368B2
(ja)
|
1991-01-16 |
2002-02-25 |
シェリング・コーポレーション |
インターロイキン−１０による腫瘍性疾患の処置
|
|
US5624823A
(en)
|
1991-11-22 |
1997-04-29 |
The General Hospital Corporation |
DNA encoding procine interleukin-10
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
WO1994004180A2
(en)
|
1992-08-20 |
1994-03-03 |
Schering Corporation |
Novel uses of il-4 and/or il-10, and antibodies against the same
|
|
AU6000894A
(en)
|
1993-02-01 |
1994-08-29 |
Michel Goldman |
Use of a pharmaceutical composition comprising an effective amount of interleukin-10, an analog and/or an agonist of interleukin-10
|
|
US5328989A
(en)
|
1993-03-05 |
1994-07-12 |
Schering-Plough |
Purification of human interleukin-10 from a cell culture medium
|
|
US5665345A
(en)
|
1993-05-24 |
1997-09-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Methods of inhibiting viral replication using IL-10
|
|
HUT73463A
(en)
|
1993-07-26 |
1996-08-28 |
Schering Corp |
Agonists and antagonists of human interleukin-10
|
|
GB9317618D0
(en)
|
1993-08-24 |
1993-10-06 |
Royal Free Hosp School Med |
Polymer modifications
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
CN1142186A
(zh)
|
1994-01-20 |
1997-02-05 |
先灵公司 |
用白介素-10激活外周血单核细胞的细胞溶解活性
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US6410008B1
(en)
|
1994-12-12 |
2002-06-25 |
Beth Israel Hospital Association |
Chimeric IL-10 proteins and uses thereof
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US5866134A
(en)
|
1995-03-24 |
1999-02-02 |
Schering Corporation |
Method for enhancing the antibody response to specific antigens with Interleukin-10
|
|
US5770190A
(en)
|
1995-07-14 |
1998-06-23 |
Schering Corporation |
Method of treatment of acute leukemia with inteleukin-10
|
|
GB2304047A
(en)
|
1995-08-09 |
1997-03-12 |
Univ Manchester |
Pharmaceutical compositions containing cytokines
|
|
US5744451A
(en)
|
1995-09-12 |
1998-04-28 |
Warner-Lambert Company |
N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
|
|
US5908621A
(en)
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
|
US5945097A
(en)
*
|
1996-09-06 |
1999-08-31 |
Schering Corporation |
Method for lowering cholesterol levels with interleukin-10
|
|
EP0925072A2
(en)
*
|
1996-09-06 |
1999-06-30 |
Schering Corporation |
Method for lowering cholesterol levels
|
|
US5989867A
(en)
|
1996-09-23 |
1999-11-23 |
Knappe; Andrea |
DNA encoding IL-10-like homologue; related reagents
|
|
US6660258B1
(en)
|
1997-05-09 |
2003-12-09 |
Pharma Pacific Pty Ltd |
Oromucosal cytokine compositions and uses thereof
|
|
IL133974A0
(en)
|
1997-07-14 |
2001-04-30 |
Bolder Biotechnology Inc |
Derivatives of growth hormone and related proteins
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
US6428985B1
(en)
|
1998-12-02 |
2002-08-06 |
The Regents Of The University Of Michigan |
Immunosuppressive structural definition of IL-10
|
|
AU2158000A
(en)
|
1998-12-22 |
2000-07-12 |
Schering Corporation |
Treatment of hepatitis c virus infections with interleukin-10
|
|
US7666400B2
(en)
|
2005-04-06 |
2010-02-23 |
Ibc Pharmaceuticals, Inc. |
PEGylation by the dock and lock (DNL) technique
|
|
WO2001005821A2
(en)
|
1999-07-16 |
2001-01-25 |
Maria Teresa Bejarano |
Viral il-10 for the inhibition of angiogenesis, tumorigenesis and metastasis
|
|
US6989377B2
(en)
|
1999-12-21 |
2006-01-24 |
Wisconsin Alumni Research Foundation |
Treating vitamin D responsive diseases
|
|
AU2001231532A1
(en)
|
2000-02-11 |
2001-08-20 |
Maxygen Aps |
Improved interleukin 10
|
|
US20030186386A1
(en)
|
2000-02-11 |
2003-10-02 |
Hansen Christian Karsten |
Interleukin 10
|
|
WO2002026265A2
(en)
|
2000-09-29 |
2002-04-04 |
Schering Corporation |
Pegylated interleukin-10
|
|
JP2002142770A
(ja)
|
2000-11-08 |
2002-05-21 |
Dnavec Research Inc |
循環系への遺伝子送達用パラミクソウイルスベクター
|
|
US6838452B2
(en)
|
2000-11-24 |
2005-01-04 |
Vascular Biogenics Ltd. |
Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
|
|
EP1234583A1
(en)
|
2001-02-23 |
2002-08-28 |
F. Hoffmann-La Roche Ag |
PEG-conjugates of HGF-NK4
|
|
GB0212648D0
(en)
|
2002-05-31 |
2002-07-10 |
Immunoclin Lab Ltd |
Treatment with cytokines
|
|
DE60332358D1
(de)
|
2002-09-09 |
2010-06-10 |
Hanall Pharmaceutical Co Ltd |
Protease-resistente modifizierte interferon alpha polypeptide
|
|
AU2003280315A1
(en)
|
2002-11-14 |
2004-06-03 |
Maxygen, Inc. |
Conjugates of interleukin-10 and polymers
|
|
DK1565183T3
(da)
|
2002-11-29 |
2008-12-01 |
Maria Grazia Roncarolo |
Rapamycin og IL-10 til behandling af autoimmune sygdomme
|
|
AU2003303222A1
(en)
|
2002-12-19 |
2004-07-14 |
Universiteit Gent |
Mutant proteins showing increased secretion
|
|
CN1753912B
(zh)
|
2002-12-23 |
2011-11-02 |
惠氏公司 |
抗pd-1抗体及其用途
|
|
PL396711A1
(pl)
|
2002-12-26 |
2011-12-19 |
Mountain View Pharmaceuticals, Inc. |
Koniugaty polimerów z cytokinami, chemokinami, czynnikami wzrostu, hormonami polipeptydowymi i ich antagonistami, kompozycja farmaceutyczna i sposób zapobiegania, diagnozowania lub leczenia
|
|
US20050214859A1
(en)
|
2003-03-03 |
2005-09-29 |
Dyax Corp. |
Peptides that specifically bind HGF receptor (cMet) and uses thereof
|
|
EP2261244A3
(en)
|
2003-04-15 |
2011-02-23 |
Glaxosmithkline LLC |
Human il-18 substitution mutants and their conjugates
|
|
US7261882B2
(en)
|
2003-06-23 |
2007-08-28 |
Reagents Of The University Of Colorado |
Methods for treating neuropathic pain by administering IL-10 polypeptides
|
|
DE602004025509D1
(de)
|
2003-11-28 |
2010-03-25 |
Univ Sydney |
Virales latentphasen-interleukin-10-(vii-10) und verwendungen davon
|
|
CA2558738C
(en)
|
2004-03-11 |
2013-02-05 |
Fresenius Kabi Deutschland Gmbh |
Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
|
|
PT2409713E
(pt)
|
2004-08-10 |
2015-10-09 |
Genzyme Corp |
Oligonucleótidos para utilização em modulação dos níveis de lipoproteínas e colesterol em humanos
|
|
US20060046961A1
(en)
|
2004-09-02 |
2006-03-02 |
Mckay William F |
Controlled and directed local delivery of anti-inflammatory compositions
|
|
CN100334112C
(zh)
|
2004-10-15 |
2007-08-29 |
上海海欣生物技术有限公司 |
人白细胞介素15与Fc融合蛋白
|
|
GB0500643D0
(en)
|
2005-01-13 |
2005-02-23 |
Renovo Ltd |
Medicaments
|
|
UY29460A1
(es)
|
2005-04-08 |
2006-11-30 |
Noxxon Pharma Ag |
Acidos nucleicos de union a ghrelin
|
|
WO2006119170A2
(en)
|
2005-05-02 |
2006-11-09 |
Avigen, Inc. |
Use of cytokine-derived peptides in treatment of pain and neurodegenerative disease
|
|
JP4992025B2
(ja)
|
2005-05-31 |
2012-08-08 |
ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイト |
変異体ｉｌ−１０
|
|
CA2655511C
(en)
|
2005-07-01 |
2017-03-21 |
John Schrader |
Methods of isolating cells and generating monoclonal antibodies
|
|
DE602006018969D1
(de)
|
2005-10-04 |
2011-01-27 |
Bristol Myers Squibb Co |
Herstellung und reinigung von il-29
|
|
US7939056B2
(en)
|
2005-11-14 |
2011-05-10 |
The Brigham And Women's Hospital, Inc. |
Interleukin-10 compositions for the treatment of adenocarcinomas
|
|
WO2007087576A2
(en)
|
2006-01-24 |
2007-08-02 |
The Uab Research Foundation |
Compositions and methods for the identification and treatment of immune-mediated inflammatory diseases
|
|
KR20090027693A
(ko)
|
2006-05-31 |
2009-03-17 |
디나벡크 가부시키가이샤 |
알츠하이머병 치료제
|
|
WO2008054585A2
(en)
|
2006-09-28 |
2008-05-08 |
Schering Corporation |
Use of pegylated il-10 to treat cancer
|
|
JP2010506166A
(ja)
|
2006-10-05 |
2010-02-25 |
エージェンシー フォー サイエンス，テクノロジー アンド リサーチ |
デング熱の診断及び治療
|
|
CA2708004C
(en)
|
2006-12-04 |
2015-12-01 |
Promedior, Inc. |
Conjoint therapy for treating fibrotic diseases
|
|
WO2008089491A2
(en)
|
2007-01-19 |
2008-07-24 |
Kai Pharmaceuticals, Inc. |
Modifications of peptide compositions to increase stability and delivery efficiency
|
|
AU2008281913B2
(en)
|
2007-07-31 |
2013-11-07 |
Affibody Ab |
New albumin binding compositions, methods and uses
|
|
WO2009036568A1
(en)
|
2007-09-19 |
2009-03-26 |
University Health Network |
Methods and compositions for treating tumors and viral infections
|
|
WO2009052454A2
(en)
|
2007-10-19 |
2009-04-23 |
University Of California |
Compositions and methods for ameliorating cns inflammation, psychosis, delirium, ptsd or ptss
|
|
EP2219458B1
(en)
|
2007-11-08 |
2015-07-15 |
Cytimmune Sciences, Inc. |
Compositions and methods for generating antibodies
|
|
GB0724231D0
(en)
|
2007-12-12 |
2008-01-30 |
Renono Ltd |
Methods for inhibiting scarring
|
|
AU2009255357A1
(en)
|
2008-05-29 |
2009-12-10 |
Bristol-Myers Squibb Company |
Methods for predicting patient response to modulation of the co-stimulatory pathway
|
|
WO2010022227A1
(en)
|
2008-08-20 |
2010-02-25 |
Schering Corporation |
Methods for monitoring il-10 therapy
|
|
JP5677972B2
(ja)
|
2008-11-18 |
2015-02-25 |
メリマック ファーマシューティカルズ インコーポレーティッド |
ヒト血清アルブミンリンカーおよびそのコンジュゲート
|
|
JP5888980B2
(ja)
*
|
2008-12-17 |
2016-03-22 |
メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． |
モノ−およびジ−ｐｅｇｉｌ１０の製造および用途
|
|
US10464987B2
(en)
|
2009-10-06 |
2019-11-05 |
Abbvie Inc. |
Human single-chain T cell receptors
|
|
US8435516B2
(en)
|
2009-10-12 |
2013-05-07 |
Pfizer Inc. |
Cancer treatment
|
|
BR112012009450A2
(pt)
|
2009-10-30 |
2017-05-23 |
Novozymes Biopharma Dk As |
variantes de albumina
|
|
CA2782004A1
(en)
|
2009-11-30 |
2011-06-03 |
Biotest Ag |
Humanized anti-il-10 antibodies for the treatment of systemic lupus erythematosus (sle)
|
|
KR20130088131A
(ko)
|
2010-06-16 |
2013-08-07 |
아비에 인코포레이티드 |
단백질 시료들의 비교
|
|
WO2011159877A2
(en)
|
2010-06-18 |
2011-12-22 |
The Brigham And Women's Hospital, Inc. |
Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
|
|
WO2012004384A2
(en)
|
2010-07-09 |
2012-01-12 |
Affibody Ab |
Polypeptides
|
|
EA201390450A1
(ru)
|
2010-09-28 |
2013-07-30 |
Амилин Фармасьютикалс, Ллк. |
Полипептиды с увеличенной продолжительностью действия
|
|
PT2621515T
(pt)
|
2010-09-28 |
2017-07-12 |
Aegerion Pharmaceuticals Inc |
Polipéptido quimérico de leptina de foca-ser humano com solubilidade aumentada
|
|
US8895536B2
(en)
|
2010-10-29 |
2014-11-25 |
Infirst Healthcare Ltd. |
Compositions and methods for treating chronic inflammation and inflammatory diseases
|
|
GB201018289D0
(en)
|
2010-10-29 |
2010-12-15 |
Biocopea Ltd |
Treatment of respiratory disorders
|
|
RU2688185C2
(ru)
|
2011-03-23 |
2019-05-21 |
Фред Хатчинсон Кэнсер Рисерч Сентер |
Способ и композиции для клеточной иммунотерапии
|
|
CN102145178B
(zh)
|
2011-04-15 |
2012-09-26 |
北京凯因科技股份有限公司 |
Peg化白介素15
|
|
WO2013059323A1
(en)
|
2011-10-18 |
2013-04-25 |
Prolynx Llc |
Peg conjugates of exenatide
|
|
WO2013074916A1
(en)
|
2011-11-18 |
2013-05-23 |
Board Of Regents, The University Of Texas System |
Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
|
|
US9714276B2
(en)
|
2012-01-26 |
2017-07-25 |
Amgen Inc. |
Growth differentiation factor 15 (GDF-15) polypeptides
|
|
CN104245722A
(zh)
|
2012-02-29 |
2014-12-24 |
Ambrx公司 |
白细胞介素-10多肽结合物和其用途
|
|
US20150118244A1
(en)
|
2012-05-10 |
2015-04-30 |
Bristol-Myers Squibb Company |
Anti-tumor antibodies as predictive or prognostic biomarkers of efficacy and survival in ipilimumab-treated patients
|
|
WO2014110867A1
(zh)
|
2013-01-17 |
2014-07-24 |
厦门赛诺邦格生物科技有限公司 |
一种单一官能化的支化聚乙二醇及其修饰的生物相关物质
|
|
AU2014254019B2
(en)
*
|
2013-04-18 |
2018-09-27 |
Armo Biosciences, Inc. |
Methods of using interleukin-10 for treating diseases and disorders
|
|
US20160068583A1
(en)
*
|
2013-04-24 |
2016-03-10 |
Armo Biosciences, Inc. |
Interleukin-10 Compositions and Uses Thereof
|
|
CA2914837A1
(en)
*
|
2013-06-17 |
2014-12-24 |
Armo Biosciences, Inc. |
Method for assessing protein identity and stability
|
|
MX2016005915A
(es)
|
2013-11-11 |
2016-12-16 |
Armo Biosciences Inc |
Metodos de uso de interleucina-10 para tratar enfermedades y trastornos.
|
|
WO2015108785A1
(en)
|
2014-01-15 |
2015-07-23 |
Armo Biosciences, Inc. |
Methods of using interleukin-10 for treating diseases and disorders
|
|
EP4303229A3
(en)
|
2014-01-21 |
2024-04-17 |
Novartis AG |
Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
|
|
MA39711A
(fr)
|
2014-04-03 |
2015-10-08 |
Nektar Therapeutics |
Conjugués d'une fraction d'il-15 et d'un polymère
|
|
AU2016268403A1
(en)
|
2015-05-28 |
2017-12-07 |
Armo Biosciences, Inc. |
Pegylated interleukin-10 for use in treating cancer
|