JP2013507131A5 - - Google Patents

Info

Publication number

JP2013507131A5

JP2013507131A5 JP2012533375A JP2012533375A JP2013507131A5 JP 2013507131 A5 JP2013507131 A5 JP 2013507131A5 JP 2012533375 A JP2012533375 A JP 2012533375A JP 2012533375 A JP2012533375 A JP 2012533375A JP 2013507131 A5 JP2013507131 A5 JP 2013507131A5

Authority

JP

Japan

Prior art keywords

fusion antibody

acid sequence

amino acid

fusion

sulfatase

Prior art date

2010-10-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 230000004927 fusion Effects 0.000 claims 32
• 125000003275 alpha amino acid group Chemical group 0.000 claims 20
• 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 8
• 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 8
• 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 8
• 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 8
• 230000008499 blood brain barrier function Effects 0.000 claims 7
• 210000001218 blood-brain barrier Anatomy 0.000 claims 7
• 230000000694 effects Effects 0.000 claims 7
• 108020001507 fusion proteins Proteins 0.000 claims 6
• 102000037865 fusion proteins Human genes 0.000 claims 6
• 210000004899 c-terminal region Anatomy 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 4
• 108091033319 polynucleotide Proteins 0.000 claims 4
• 102000040430 polynucleotide Human genes 0.000 claims 4
• 239000002157 polynucleotide Substances 0.000 claims 4
• 102000005962 receptors Human genes 0.000 claims 3
• 108020003175 receptors Proteins 0.000 claims 3
• 102000003746 Insulin Receptor Human genes 0.000 claims 2
• 108010001127 Insulin Receptor Proteins 0.000 claims 2
• 102000005262 Sulfatase Human genes 0.000 claims 2
• 230000037396 body weight Effects 0.000 claims 2
• 108060007951 sulfatase Proteins 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000699802 Cricetulus griseus Species 0.000 claims 1
• 229920000045 Dermatan sulfate Polymers 0.000 claims 1
• 229920002971 Heparan sulfate Polymers 0.000 claims 1
• 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 1
• 102100029199 Iduronate 2-sulfatase Human genes 0.000 claims 1
• 101710096421 Iduronate 2-sulfatase Proteins 0.000 claims 1
• 108060003951 Immunoglobulin Proteins 0.000 claims 1
• 102100037852 Insulin-like growth factor I Human genes 0.000 claims 1
• 102000011965 Lipoprotein Receptors Human genes 0.000 claims 1
• 108010061306 Lipoprotein Receptors Proteins 0.000 claims 1
• 101001055320 Myxine glutinosa Insulin-like growth factor Proteins 0.000 claims 1
• UGJBHEZMOKVTIM-UHFFFAOYSA-N N-formylglycine Chemical compound OC(=O)CNC=O UGJBHEZMOKVTIM-UHFFFAOYSA-N 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 102000007238 Transferrin Receptors Human genes 0.000 claims 1
• 108010033576 Transferrin Receptors Proteins 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 210000004556 brain Anatomy 0.000 claims 1
• 210000003169 central nervous system Anatomy 0.000 claims 1
• 230000007812 deficiency Effects 0.000 claims 1
• AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 1
• 229940051593 dermatan sulfate Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229920000669 heparin Polymers 0.000 claims 1
• 229960002897 heparin Drugs 0.000 claims 1
• 230000007062 hydrolysis Effects 0.000 claims 1
• 238000006460 hydrolysis reaction Methods 0.000 claims 1
• 102000018358 immunoglobulin Human genes 0.000 claims 1
• 238000001361 intraarterial administration Methods 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 102000005861 leptin receptors Human genes 0.000 claims 1
• 108010019813 leptin receptors Proteins 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 239000003607 modifier Substances 0.000 claims 1
• 150000007523 nucleic acids Chemical group 0.000 claims 1
• 210000001672 ovary Anatomy 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000000241 respiratory effect Effects 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1