JP2018535948A5 - - Google Patents

Download PDF

Info

Publication number
JP2018535948A5
JP2018535948A5 JP2018518592A JP2018518592A JP2018535948A5 JP 2018535948 A5 JP2018535948 A5 JP 2018535948A5 JP 2018518592 A JP2018518592 A JP 2018518592A JP 2018518592 A JP2018518592 A JP 2018518592A JP 2018535948 A5 JP2018535948 A5 JP 2018535948A5
Authority
JP
Japan
Prior art keywords
seq
lepr
antigen
binding fragment
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018518592A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018535948A (ja
JP7034068B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/056465 external-priority patent/WO2017066204A1/en
Publication of JP2018535948A publication Critical patent/JP2018535948A/ja
Publication of JP2018535948A5 publication Critical patent/JP2018535948A5/ja
Application granted granted Critical
Publication of JP7034068B2 publication Critical patent/JP7034068B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018518592A 2015-10-12 2016-10-11 レプチン受容体を活性化させる抗原結合タンパク質 Active JP7034068B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562240021P 2015-10-12 2015-10-12
US62/240,021 2015-10-12
US201662359757P 2016-07-08 2016-07-08
US62/359,757 2016-07-08
US201662375495P 2016-08-16 2016-08-16
US62/375,495 2016-08-16
US201662393143P 2016-09-12 2016-09-12
US62/393,143 2016-09-12
PCT/US2016/056465 WO2017066204A1 (en) 2015-10-12 2016-10-11 Antigen-binding proteins that activate the leptin receptor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021039405A Division JP7165225B2 (ja) 2015-10-12 2021-03-11 レプチン受容体を活性化させる抗原結合タンパク質

Publications (3)

Publication Number Publication Date
JP2018535948A JP2018535948A (ja) 2018-12-06
JP2018535948A5 true JP2018535948A5 (enExample) 2019-11-21
JP7034068B2 JP7034068B2 (ja) 2022-03-11

Family

ID=57184864

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2018518592A Active JP7034068B2 (ja) 2015-10-12 2016-10-11 レプチン受容体を活性化させる抗原結合タンパク質
JP2021039405A Active JP7165225B2 (ja) 2015-10-12 2021-03-11 レプチン受容体を活性化させる抗原結合タンパク質
JP2022169008A Active JP7436603B2 (ja) 2015-10-12 2022-10-21 レプチン受容体を活性化させる抗原結合タンパク質
JP2023202680A Active JP7699191B2 (ja) 2015-10-12 2023-11-30 レプチン受容体を活性化させる抗原結合タンパク質
JP2024018406A Active JP7759417B2 (ja) 2015-10-12 2024-02-09 レプチン受容体を活性化させる抗原結合タンパク質

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2021039405A Active JP7165225B2 (ja) 2015-10-12 2021-03-11 レプチン受容体を活性化させる抗原結合タンパク質
JP2022169008A Active JP7436603B2 (ja) 2015-10-12 2022-10-21 レプチン受容体を活性化させる抗原結合タンパク質
JP2023202680A Active JP7699191B2 (ja) 2015-10-12 2023-11-30 レプチン受容体を活性化させる抗原結合タンパク質
JP2024018406A Active JP7759417B2 (ja) 2015-10-12 2024-02-09 レプチン受容体を活性化させる抗原結合タンパク質

Country Status (31)

Country Link
US (6) US10023644B2 (enExample)
EP (2) EP4071173A1 (enExample)
JP (5) JP7034068B2 (enExample)
KR (2) KR20250069979A (enExample)
CN (1) CN108368177B (enExample)
AU (1) AU2016338851B2 (enExample)
CA (1) CA3000215A1 (enExample)
CL (2) CL2018000946A1 (enExample)
CO (1) CO2018003852A2 (enExample)
CY (1) CY1125102T1 (enExample)
DK (1) DK3362477T3 (enExample)
EA (1) EA201890928A1 (enExample)
ES (1) ES2908574T3 (enExample)
HR (1) HRP20220426T8 (enExample)
HU (1) HUE058280T2 (enExample)
IL (3) IL300961B2 (enExample)
LT (1) LT3362477T (enExample)
MX (2) MX2018004531A (enExample)
MY (1) MY187975A (enExample)
PH (1) PH12018500663A1 (enExample)
PL (1) PL3362477T3 (enExample)
PT (1) PT3362477T (enExample)
RS (1) RS63061B1 (enExample)
SG (1) SG10201913432RA (enExample)
SI (1) SI3362477T1 (enExample)
SM (1) SMT202200125T1 (enExample)
TW (3) TW202417497A (enExample)
UA (1) UA124419C2 (enExample)
UY (1) UY36942A (enExample)
WO (1) WO2017066204A1 (enExample)
ZA (1) ZA201801975B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016145206A1 (en) 2015-03-10 2016-09-15 Regeneron Pharmaceuticals, Inc. Aseptic piercing system and method
TW202417497A (zh) * 2015-10-12 2024-05-01 美商再生元醫藥公司 活化瘦素受體的抗原結合蛋白
EA201991075A1 (ru) * 2016-11-08 2019-10-31 Антигенсвязывающие белки, которые проявляют антагонизм в отношении лептинового рецептора
ES2919934T3 (es) 2017-05-05 2022-07-29 Regeneron Pharma Autoinyector y procedimientos de uso relacionados
KR20200100089A (ko) * 2017-12-18 2020-08-25 리제너론 파마슈티칼스 인코포레이티드 렙틴 수용체 및/또는 gp130에 결합하는 이중 특이적 항원 결합 분자 및 이의 사용 방법
LT3773713T (lt) * 2018-04-06 2025-08-25 Regeneron Pharmaceuticals, Inc. Leptino receptoriaus agonistinis antikūnas, skirtas kaulų masės didinimui subjektui, kuriam pasireiškia medžiagų apykaitos sutrikimas arba hipoleptinemija
EP3868743B8 (en) * 2018-10-11 2023-06-07 Sumitomo Chemical Company Limited Propylene oxide purification system and method for producing propylene oxide
WO2020160199A1 (en) 2019-01-31 2020-08-06 Siemens Healthcare Diagnostics Inc. Anti-naloxone and anti-naltrexone monoclonal antibodies and methods of production and use thereof
US20220288169A1 (en) * 2019-05-24 2022-09-15 The Board of Supervisors of Louisiana State University and Agriculyural and Mechanical College Compositions and methods for the treatment and prevention of hypoglycemic complications
WO2021000251A1 (en) * 2019-07-02 2021-01-07 Shanghaitech University Antibody to leptin receptor
WO2021111156A1 (en) 2019-12-03 2021-06-10 Micron Technology, Inc. Cache architecture for a storage device
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
MX2023002995A (es) 2020-09-15 2023-05-19 Regeneron Pharma Uso de agonistas de lepr para el dolor.
LT4294257T (lt) 2021-02-22 2025-12-29 Regeneron Pharmaceuticals, Inc. Dalinės lipodistrofijos diagnostikos ir gydymo būdas
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector
CN114456124B (zh) * 2021-12-30 2023-04-21 华南农业大学 一种新利司他半抗原、人工抗原、抗体及其制备方法和应用
KR20260025363A (ko) 2023-06-16 2026-02-24 리제너론 파아마슈티컬스, 인크. 의료 디바이스 패키징 및 관련 방법
WO2025075970A1 (en) 2023-10-02 2025-04-10 Regeneron Pharmaceuticals, Inc. Drug delivery device safety system
TW202602926A (zh) 2024-03-15 2026-01-16 美商美國禮來大藥廠 作為治療肥胖症之單一或組合療法之瘦素受體促效抗體
WO2025227054A1 (en) * 2024-04-25 2025-10-30 The Board Of Regents Of The University Of Texas System Monoclonal antibodies binding to leptin and uses thereof
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US5856098A (en) 1994-09-14 1999-01-05 Progenitor, Inc. Detection of a leptin receptor variant
US5643748A (en) 1994-09-14 1997-07-01 Progenitor, Inc. HU-B1.219, a novel human hematopoietin receptor
US6451523B1 (en) 1994-09-14 2002-09-17 Interneuron Pharmaceuticals, Inc. Detection of a leptin receptor variant and methods for regulating obesity
US5912123A (en) 1994-09-14 1999-06-15 Progenitor, Inc. Detection of the leptin receptor in reproductive organs and methods for regulating reproductive biology
US6482927B1 (en) 1995-11-27 2002-11-19 Millennium Pharmaceuticals, Inc. Chimeric proteins comprising the extracellular domain of murine Ob receptor
US6977240B1 (en) * 1995-11-27 2005-12-20 Millenium Pharmaceuticals, Inc. Methods of using the OB receptor antibodies to treat bodyweight disorders
EP0885299B1 (en) 1996-01-08 2005-10-26 Genentech, Inc. Ob receptor and ligands
US20050019325A1 (en) 1996-01-08 2005-01-27 Carter Paul J. WSX receptor agonist antibodies
AU2476301A (en) 1996-01-16 2001-05-24 Rockefeller University, The DB the receptor for leptin nucleic acids encoding the receptor, and uses thereof
US7063958B1 (en) 1996-01-16 2006-06-20 The Rockefeller University Nucleic acids db, the receptor for leptin
AU1833197A (en) 1996-01-18 1997-08-11 Progenitor, Inc. Detection of a leptin receptor variant and methods for regulating obesity
CA2244693A1 (en) 1996-01-23 1997-07-31 Progenitor, Inc. Methods for using the obese gene and its gene product to stimulate hematopoietic development
AUPN780096A0 (en) * 1996-01-30 1996-02-22 Medvet Science Pty. Ltd. Cytokine antagonists and agonists
US7067472B1 (en) 1996-06-04 2006-06-27 The Scripps Research Institute Diagnostic and therapeutic methods related to regulating energy mobilization with OB protein and OB antibodies
US5965521A (en) 1997-02-25 1999-10-12 Eli Lilly Company Pulsatile delivery of leptin receptor ligands
IL120733A0 (en) 1997-04-29 1997-08-14 Yeda Res & Dev Leptin as an inhibitor of cell proliferation
US6696411B1 (en) 1998-04-22 2004-02-24 Cornell Research Foundation, Inc. Canine erythropoietin gene and recombinant protein
AU767068B2 (en) 1999-06-11 2003-10-30 Baylor College Of Medicine Methods and compositions for control of bone formation via modulation of leptin activity
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20040253242A1 (en) 2000-12-05 2004-12-16 Bowdish Katherine S. Rationally designed antibodies
JP2005506994A (ja) 2001-10-22 2005-03-10 アムジェン インコーポレイテッド ヒト脂肪組織萎縮症を処置するためのレプチンの使用および該処置のための素因決定方法
US20060165683A1 (en) * 2001-12-05 2006-07-27 Gerard Karsenty Methods and compositions for control of bone formation via modulation of sympathetic tone
FR2852397B1 (fr) 2003-03-10 2005-04-29 Utilisation des genes leprotl 1 et ob-rgrp pour le criblage de composes actifs sur la prise ou la perte de poids ou le diabete d'un sujet humain ou animal.
DE10353593A1 (de) * 2003-11-17 2005-06-23 Klinikum der Universität München Großhadern-Innenstadt Leptinantagonist und Verfahren zur quantitativen Messung von Leptin
JPWO2005056602A1 (ja) * 2003-12-12 2008-03-06 中外製薬株式会社 アゴニスト活性を有する改変抗体のスクリーニング方法
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
US8969291B2 (en) 2004-10-08 2015-03-03 Enzo Therapeutics, Inc. Methods for decreasing leptin levels or activity for treating inflammation
US7863240B2 (en) 2004-10-08 2011-01-04 Enzo Therapeutics, Inc. Methods and uses of leptin in hepatocellular carcinoma
EP1812038A1 (en) 2004-11-18 2007-08-01 VIB vzw Fibronectin iii domain as leptin receptor antagonists
US8008443B2 (en) 2005-04-26 2011-08-30 Medimmune, Llc Modulation of antibody effector function by hinge domain engineering
PE20071101A1 (es) 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
WO2008140603A2 (en) 2006-12-08 2008-11-20 Macrogenics, Inc. METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING
GB0715216D0 (en) 2007-08-03 2007-09-12 Asterion Ltd Leptin
US20100260772A1 (en) 2007-09-28 2010-10-14 The Trustees Of Columbia University In The City Of New York Methods for treating or preventing diseases associated with low bone mass
WO2010054007A1 (en) 2008-11-07 2010-05-14 Fabrus Llc Combinatorial antibody libraries and uses thereof
CN102638971B (zh) 2009-07-08 2015-10-07 科马布有限公司 动物模型及治疗分子
US20120021409A1 (en) 2010-02-08 2012-01-26 Regeneron Pharmaceuticals, Inc. Common Light Chain Mouse
HRP20151188T4 (hr) 2010-02-08 2021-10-01 Regeneron Pharmaceuticals, Inc. Miš sa zajedničkim lakim lancem
KR101962483B1 (ko) 2010-11-17 2019-03-29 추가이 세이야쿠 가부시키가이샤 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
JO3756B1 (ar) * 2010-11-23 2021-01-31 Regeneron Pharma اجسام مضادة بشرية لمستقبلات الجلوكاجون
RU2013139267A (ru) 2011-02-10 2015-03-20 Рош Гликарт Аг Улучшенная иммунотерапия
LT2738259T (lt) 2011-02-25 2020-03-10 Regeneron Pharmaceuticals, Inc. Adam6 pelės
US8790651B2 (en) 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
PT3865581T (pt) 2011-08-05 2024-10-04 Regeneron Pharma Murganhos da cadeia leve universal humanizada
GB201122047D0 (en) 2011-12-21 2012-02-01 Kymab Ltd Transgenic animals
US20140013456A1 (en) 2012-03-16 2014-01-09 Regeneron Pharmaceuticals, Inc. Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
KR20150023535A (ko) 2012-06-05 2015-03-05 리제너론 파마슈티칼스 인코포레이티드 공통 경쇄를 사용하여 완전한 인간 이중 특이적 항체를 만드는 방법
EP2895513B1 (en) 2012-09-12 2018-05-23 Genzyme Corporation Fc containing polypeptides with altered glycosylation and reduced effector function
TWI682941B (zh) 2013-02-01 2020-01-21 美商再生元醫藥公司 含嵌合恆定區之抗體
TW201920262A (zh) * 2013-07-30 2019-06-01 美商再生元醫藥公司 抗活化素ａ之抗體及其用途
DK3108255T3 (da) 2014-02-18 2020-11-09 Inst Nat Sante Rech Med Fremgangsmåder og farmaceutiske sammensætninger til behandling af sygdomme medieret af nrp-1/obr-komplekssignalvejen
TW202417497A (zh) 2015-10-12 2024-05-01 美商再生元醫藥公司 活化瘦素受體的抗原結合蛋白
EA201991075A1 (ru) 2016-11-08 2019-10-31 Антигенсвязывающие белки, которые проявляют антагонизм в отношении лептинового рецептора
CN107760761A (zh) 2017-11-10 2018-03-06 江苏省农业科学院 一种加强瘦素激发lepr信号转导的方法
KR20200100089A (ko) 2017-12-18 2020-08-25 리제너론 파마슈티칼스 인코포레이티드 렙틴 수용체 및/또는 gp130에 결합하는 이중 특이적 항원 결합 분자 및 이의 사용 방법
LT3773713T (lt) 2018-04-06 2025-08-25 Regeneron Pharmaceuticals, Inc. Leptino receptoriaus agonistinis antikūnas, skirtas kaulų masės didinimui subjektui, kuriam pasireiškia medžiagų apykaitos sutrikimas arba hipoleptinemija

Similar Documents

Publication Publication Date Title
CN106068125B (zh) 治疗脂肪组织积聚的组合物和方法
JP2011506483A5 (enExample)
HRP20220426T1 (hr) Proteini koji vezuju antigen koji aktiviraju receptor leptina
US20230233675A1 (en) Methods, regimens, combinations & antagonists
CN102027015A (zh) 抗cxcr4抗体
ES3001197T3 (es) Agente de unión anti-adrenomedulina (ADM) para su uso en la terapia o prevención de síntomas de enfermedad
JP2021525718A5 (enExample)
RU2014117510A (ru) Лечение ревматоидного артрита
WO2016122996A1 (en) Vegfa/ang2 compounds
JP2022513421A5 (enExample)
KR20250122524A (ko) 미오스타틴 활성화의 선택적이고 강력한 억제 항체
JP2022547452A (ja) Ａｃｔｒｉｉ受容体拮抗薬を含む肝疾患または肝臓障害の治療
CA3169994A1 (en) Methods for the treatment of scleroderma and related conditions
KR20250084991A (ko) 항-FcRN 항체를 이용한 만성 염증성 탈수초성 다발성 신경병증의 치료 방법
JP2022520107A5 (enExample)
EP3145544B1 (en) Ang2 antibodies
AU2009322587B2 (en) Anti-ferroportin 1 monoclonal antibodies and uses thereof
EP3411066B1 (en) Parathyroid hormone anti-rankl antibody fusion compounds
JP2009538916A5 (enExample)
CA2638869A1 (en) Humanized anti-ghrelin antibodies
TWI454481B (zh) 結合ＴＧＦ－α及表皮調節素（ＥＰＩＲＥＧＵＬＩＮ）之抗體
JP2018533588A (ja) 治療パラダイム
EP4584294A1 (en) Methods of treating graves' disease using anti-fcrn antibodies
CN119584995A (zh) 组合疗法
JP2023539107A5 (enExample)