RS63061B1 - Proteini koji vezuju antigen koji aktiviraju receptor leptina - Google Patents

Proteini koji vezuju antigen koji aktiviraju receptor leptina

Info

Publication number
RS63061B1
RS63061B1 RS20220294A RSP20220294A RS63061B1 RS 63061 B1 RS63061 B1 RS 63061B1 RS 20220294 A RS20220294 A RS 20220294A RS P20220294 A RSP20220294 A RS P20220294A RS 63061 B1 RS63061 B1 RS 63061B1
Authority
RS
Serbia
Prior art keywords
antigen
activate
binding proteins
leptin receptor
leptin
Prior art date
Application number
RS20220294A
Other languages
English (en)
Inventor
Jesper Gromada
Panayiotis Stevis
Judith ALTAREJOS
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57184864&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS63061(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of RS63061B1 publication Critical patent/RS63061B1/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RS20220294A 2015-10-12 2016-10-11 Proteini koji vezuju antigen koji aktiviraju receptor leptina RS63061B1 (sr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562240021P 2015-10-12 2015-10-12
US201662359757P 2016-07-08 2016-07-08
US201662375495P 2016-08-16 2016-08-16
US201662393143P 2016-09-12 2016-09-12
PCT/US2016/056465 WO2017066204A1 (en) 2015-10-12 2016-10-11 Antigen-binding proteins that activate the leptin receptor
EP16785072.6A EP3362477B1 (en) 2015-10-12 2016-10-11 Antigen-binding proteins that activate the leptin receptor

Publications (1)

Publication Number Publication Date
RS63061B1 true RS63061B1 (sr) 2022-04-29

Family

ID=57184864

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20220294A RS63061B1 (sr) 2015-10-12 2016-10-11 Proteini koji vezuju antigen koji aktiviraju receptor leptina

Country Status (32)

Country Link
US (5) US10023644B2 (sr)
EP (2) EP4071173A1 (sr)
JP (5) JP7034068B2 (sr)
KR (1) KR20180070609A (sr)
CN (1) CN108368177B (sr)
AU (2) AU2016338851B2 (sr)
BR (1) BR112018007318A2 (sr)
CA (1) CA3000215A1 (sr)
CL (2) CL2018000946A1 (sr)
CO (1) CO2018003852A2 (sr)
CY (1) CY1125102T1 (sr)
DK (1) DK3362477T3 (sr)
EA (1) EA201890928A1 (sr)
ES (1) ES2908574T3 (sr)
HK (1) HK1254862A1 (sr)
HR (1) HRP20220426T8 (sr)
HU (1) HUE058280T2 (sr)
IL (2) IL300961A (sr)
LT (1) LT3362477T (sr)
MX (2) MX2018004531A (sr)
MY (1) MY187975A (sr)
PH (1) PH12018500663A1 (sr)
PL (1) PL3362477T3 (sr)
PT (1) PT3362477T (sr)
RS (1) RS63061B1 (sr)
SG (1) SG10201913432RA (sr)
SI (1) SI3362477T1 (sr)
TW (2) TWI824372B (sr)
UA (1) UA124419C2 (sr)
UY (1) UY36942A (sr)
WO (1) WO2017066204A1 (sr)
ZA (1) ZA201801975B (sr)

Families Citing this family (12)

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TWI824372B (zh) 2015-10-12 2023-12-01 美商再生元醫藥公司 活化瘦素受體的抗原結合蛋白
MA45801B1 (fr) 2016-11-08 2021-11-30 Regeneron Pharma Protéines de liaison à l'antigène qui sont des antagonistes du récepteur de leptine
MA51289A (fr) 2017-12-18 2021-03-24 Regeneron Pharma Molécules de liaison à l'antigène bispécifiques se liant au récepteur de la leptine et/ou à gp130, et leurs procédés d'utilisation
MX2020010547A (es) * 2018-04-06 2020-11-06 Regeneron Pharma Anticuerpo agonista del receptor de leptina para usarse en el tratamiento de una disfuncion metabolica o hipoleptinemia.
SG11202101638YA (en) * 2018-10-11 2021-03-30 Sumitomo Chemical Co Propylene oxide purification system and method for producing propylene oxide
WO2020160199A1 (en) * 2019-01-31 2020-08-06 Siemens Healthcare Diagnostics Inc. Anti-naloxone and anti-naltrexone monoclonal antibodies and methods of production and use thereof
CN114391022B (zh) * 2019-07-02 2023-12-12 上海科技大学 抗瘦素受体的抗体
WO2021111156A1 (en) 2019-12-03 2021-06-10 Micron Technology, Inc. Cache architecture for a storage device
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
CA3192156A1 (en) * 2020-09-15 2022-03-24 Regeneron Pharmaceuticals, Inc. Use of lepr agonists for pain
US20240153638A1 (en) 2021-02-22 2024-05-09 Regeneron Pharmaceuticals, Inc. Method for diagnosing and treating partial lipodystrophy
CN114456124B (zh) * 2021-12-30 2023-04-21 华南农业大学 一种新利司他半抗原、人工抗原、抗体及其制备方法和应用

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US6451523B1 (en) 1994-09-14 2002-09-17 Interneuron Pharmaceuticals, Inc. Detection of a leptin receptor variant and methods for regulating obesity
US5912123A (en) 1994-09-14 1999-06-15 Progenitor, Inc. Detection of the leptin receptor in reproductive organs and methods for regulating reproductive biology
US5856098A (en) 1994-09-14 1999-01-05 Progenitor, Inc. Detection of a leptin receptor variant
US6977240B1 (en) * 1995-11-27 2005-12-20 Millenium Pharmaceuticals, Inc. Methods of using the OB receptor antibodies to treat bodyweight disorders
US6482927B1 (en) 1995-11-27 2002-11-19 Millennium Pharmaceuticals, Inc. Chimeric proteins comprising the extracellular domain of murine Ob receptor
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US20050019325A1 (en) 1996-01-08 2005-01-27 Carter Paul J. WSX receptor agonist antibodies
AU2476301A (en) 1996-01-16 2001-05-24 Rockefeller University, The DB the receptor for leptin nucleic acids encoding the receptor, and uses thereof
AU1833197A (en) 1996-01-18 1997-08-11 Progenitor, Inc. Detection of a leptin receptor variant and methods for regulating obesity
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AUPN780096A0 (en) * 1996-01-30 1996-02-22 Medvet Science Pty. Ltd. Cytokine antagonists and agonists
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JPWO2005056602A1 (ja) * 2003-12-12 2008-03-06 中外製薬株式会社 アゴニスト活性を有する改変抗体のスクリーニング方法
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JO3756B1 (ar) * 2010-11-23 2021-01-31 Regeneron Pharma اجسام مضادة بشرية لمستقبلات الجلوكاجون
KR102426488B1 (ko) 2012-09-12 2022-07-28 젠자임 코포레이션 변경된 당화 및 감소된 효과기 기능을 갖는 fc 함유 폴리펩티드
TWI635098B (zh) 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體
TW201920262A (zh) * 2013-07-30 2019-06-01 美商再生元醫藥公司 抗活化素a之抗體及其用途
JP6666848B2 (ja) 2014-02-18 2020-03-18 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Nrp−1/obr複合体シグナル伝達経路により媒介される疾患の処置のための方法及び医薬組成物
TWI824372B (zh) 2015-10-12 2023-12-01 美商再生元醫藥公司 活化瘦素受體的抗原結合蛋白
MA51289A (fr) 2017-12-18 2021-03-24 Regeneron Pharma Molécules de liaison à l'antigène bispécifiques se liant au récepteur de la leptine et/ou à gp130, et leurs procédés d'utilisation

Also Published As

Publication number Publication date
CO2018003852A2 (es) 2018-07-10
US10253102B2 (en) 2019-04-09
JP2024042114A (ja) 2024-03-27
UA124419C2 (uk) 2021-09-15
SI3362477T1 (sl) 2022-04-29
DK3362477T3 (da) 2022-03-07
IL258448A (en) 2018-05-31
ZA201801975B (en) 2020-07-29
IL258448B2 (en) 2023-08-01
CN108368177B (zh) 2022-05-31
US20180282420A1 (en) 2018-10-04
TW201726737A (zh) 2017-08-01
ES2908574T3 (es) 2022-05-03
HUE058280T2 (hu) 2022-07-28
AU2016338851A1 (en) 2018-04-19
JP7034068B2 (ja) 2022-03-11
US20200031946A1 (en) 2020-01-30
WO2017066204A1 (en) 2017-04-20
IL300961A (en) 2023-04-01
CY1125102T1 (el) 2024-02-16
SG10201913432RA (en) 2020-03-30
HRP20220426T1 (hr) 2022-05-27
EP3362477B1 (en) 2022-01-05
PT3362477T (pt) 2022-03-02
JP2021090461A (ja) 2021-06-17
MY187975A (en) 2021-11-05
TW202216785A (zh) 2022-05-01
CL2018000946A1 (es) 2018-12-14
KR20180070609A (ko) 2018-06-26
UY36942A (es) 2017-05-31
BR112018007318A2 (pt) 2018-10-23
US10023644B2 (en) 2018-07-17
US20220112293A1 (en) 2022-04-14
PL3362477T3 (pl) 2022-05-02
CA3000215A1 (en) 2017-04-20
EP4071173A1 (en) 2022-10-12
JP2023002713A (ja) 2023-01-10
IL258448B1 (en) 2023-04-01
MX2023000738A (es) 2023-02-13
AU2023206125A1 (en) 2023-08-31
HRP20220426T8 (hr) 2022-06-10
EP3362477A1 (en) 2018-08-22
TWI824372B (zh) 2023-12-01
JP7436603B2 (ja) 2024-02-21
HK1254862A1 (zh) 2019-07-26
US20180282421A1 (en) 2018-10-04
TWI752920B (zh) 2022-01-21
CN108368177A (zh) 2018-08-03
JP7165225B2 (ja) 2022-11-02
US20170101477A1 (en) 2017-04-13
LT3362477T (lt) 2022-03-10
JP2018535948A (ja) 2018-12-06
MX2018004531A (es) 2018-09-12
JP2024026230A (ja) 2024-02-28
EA201890928A1 (ru) 2018-09-28
AU2016338851B2 (en) 2023-08-10
US10618968B2 (en) 2020-04-14
PH12018500663A1 (en) 2018-10-01
CL2019001434A1 (es) 2019-10-11

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