JP2010540660A5 - - Google Patents

Info

Publication number

JP2010540660A5

JP2010540660A5 JP2010528167A JP2010528167A JP2010540660A5 JP 2010540660 A5 JP2010540660 A5 JP 2010540660A5 JP 2010528167 A JP2010528167 A JP 2010528167A JP 2010528167 A JP2010528167 A JP 2010528167A JP 2010540660 A5 JP2010540660 A5 JP 2010540660A5

Authority

JP

Japan

Prior art keywords

antibody

mammal

composition

administration

agonist

Prior art date

2008-10-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 241000124008 Mammalia Species 0.000 claims 6
• 102000012220 Member 14 Tumor Necrosis Factor Receptors Human genes 0.000 claims 5
• 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 5
• 239000000556 agonist Substances 0.000 claims 3
• 230000010437 erythropoiesis Effects 0.000 claims 3
• 102000003951 Erythropoietin Human genes 0.000 claims 2
• 108090000394 Erythropoietin Proteins 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 208000007502 anemia Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 229940105423 erythropoietin Drugs 0.000 claims 2
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 208000001647 Renal Insufficiency Diseases 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 238000011260 co-administration Methods 0.000 claims 1
• 235000018417 cysteine Nutrition 0.000 claims 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 102000052793 human TNFRSF14 Human genes 0.000 claims 1
• 201000006370 kidney failure Diseases 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 235000018102 proteins Nutrition 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 239000000018 receptor agonist Substances 0.000 claims 1
• 229940044601 receptor agonist Drugs 0.000 claims 1
• 230000004936 stimulating effect Effects 0.000 claims 1
• 230000000638 stimulation Effects 0.000 claims 1