|
US4475196A
(en)
|
1981-03-06 |
1984-10-02 |
Zor Clair G |
Instrument for locating faults in aircraft passenger reading light and attendant call control system
|
|
US4447233A
(en)
|
1981-04-10 |
1984-05-08 |
Parker-Hannifin Corporation |
Medication infusion pump
|
|
US4439196A
(en)
|
1982-03-18 |
1984-03-27 |
Merck & Co., Inc. |
Osmotic drug delivery system
|
|
US4447224A
(en)
|
1982-09-20 |
1984-05-08 |
Infusaid Corporation |
Variable flow implantable infusion apparatus
|
|
US4487603A
(en)
|
1982-11-26 |
1984-12-11 |
Cordis Corporation |
Implantable microinfusion pump system
|
|
US4486194A
(en)
|
1983-06-08 |
1984-12-04 |
James Ferrara |
Therapeutic device for administering medicaments through the skin
|
|
US4596556A
(en)
|
1985-03-25 |
1986-06-24 |
Bioject, Inc. |
Hypodermic injection apparatus
|
|
US4941880A
(en)
|
1987-06-19 |
1990-07-17 |
Bioject, Inc. |
Pre-filled ampule and non-invasive hypodermic injection device assembly
|
|
US4790824A
(en)
|
1987-06-19 |
1988-12-13 |
Bioject, Inc. |
Non-invasive hypodermic injection device
|
|
SE8804164A0
(sv)
|
1988-11-17 |
1990-05-18 |
Per Prisell |
Farmaceutisk beredning
|
|
US5064413A
(en)
|
1989-11-09 |
1991-11-12 |
Bioject, Inc. |
Needleless hypodermic injection device
|
|
US5312335A
(en)
|
1989-11-09 |
1994-05-17 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
US5177197A
(en)
|
1990-02-27 |
1993-01-05 |
Ludwig Institute For Cancer Research |
Isolated nucleotide sequence expressing human transforming growth factor-β1-binding protein
|
|
US5229495A
(en)
|
1991-06-18 |
1993-07-20 |
Ludwig Institute For Cancer Research |
Substantially pure receptor like TGF-β 1 binding molecules and uses thereof
|
|
US5383851A
(en)
|
1992-07-24 |
1995-01-24 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
DK0662146T3
(da)
|
1992-09-03 |
2000-11-13 |
Univ California |
Dorsalvævpåvirkende faktor og præparat
|
|
US5453492A
(en)
|
1993-07-28 |
1995-09-26 |
La Jolla Cancer Research Foundation |
60 kDa transforming growth factor-β-binding protein and its use to detect or purify TGF-β
|
|
JPH09512910A
(ja)
|
1994-05-04 |
1997-12-22 |
マウント・サイナイ・ホスピタル・コーポレイション |
TGF−βスーパーファミリーのサイトカインの変調因子およびそのアッセイ方法
|
|
US5616561A
(en)
|
1995-03-31 |
1997-04-01 |
Regents Of The University Of California |
TGF-β antagonists as mitigators of radiation-induced tissue damage
|
|
JP4062551B2
(ja)
|
1997-04-29 |
2008-03-19 |
リジェネロン ファーマシューティカルズ,インコーポレイテッド |
ヒトケルベロスタンパク質
|
|
CA2292899A1
(en)
|
1997-06-06 |
1998-12-10 |
Regeneron Pharmaceuticals, Inc. |
Ntn-2 member of tnf ligand family
|
|
US5935852A
(en)
|
1997-07-03 |
1999-08-10 |
Genetics Institute, Inc. |
DNA molecules encoding mammalian cerberus-like proteins
|
|
WO1999061044A1
(en)
|
1998-05-28 |
1999-12-02 |
The Board Of Trustees Of The University Of Arkansas |
Noggin and antagonists of bone morphogenetic proteins to suppress pathologic bone resorption
|
|
WO2000022909A2
(en)
|
1998-10-19 |
2000-04-27 |
Biotech Australia Pty. Limited |
Systems for oral delivery
|
|
JP4813660B2
(ja)
|
1998-11-27 |
2011-11-09 |
ダーウィン ディスカバリー リミテッド |
骨鉱化作用を増加するための組成物および方法
|
|
US20040009535A1
(en)
|
1998-11-27 |
2004-01-15 |
Celltech R&D, Inc. |
Compositions and methods for increasing bone mineralization
|
|
AU3511100A
(en)
|
1999-03-12 |
2000-10-04 |
Regeneron Pharmaceuticals, Inc. |
Novel nucleic acids and polypeptides
|
|
US7358056B1
(en)
|
1999-08-30 |
2008-04-15 |
Signal Pharmaceuticals |
Methods for modulating signal transduction mediated by TGF-β and related proteins
|
|
CA2395926A1
(en)
|
1999-12-28 |
2001-07-05 |
Curagen Corporation |
Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
|
|
WO2001053836A2
(en)
|
2000-01-24 |
2001-07-26 |
Millennium Pharmaceuticals, Inc. |
Identification, assessment, prevention, and therapy of prostate cancer
|
|
WO2001055388A1
(en)
|
2000-01-31 |
2001-08-02 |
Human Genome Sciences, Inc. |
Nucleic acids, proteins, and antibodies
|
|
US20020081590A1
(en)
|
2000-02-04 |
2002-06-27 |
Aeomica, Inc. |
Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
|
|
AU6459801A
(en)
|
2000-05-12 |
2001-11-26 |
Mark T Keating |
Compositions and methods for cell dedifferentiation and tissue regeneration
|
|
US20040087016A1
(en)
|
2000-05-12 |
2004-05-06 |
University Of Utah Research Foundation |
Compositions and methods for cell dedifferentiation and tissue regeneration
|
|
CA2410912A1
(en)
|
2000-06-01 |
2001-12-06 |
Amgen, Inc. |
Cystine-knot polypeptides: cloaked-2 molecules and uses thereof
|
|
CA2412110A1
(en)
|
2000-06-19 |
2001-12-27 |
F. Hoffmann-La Roche Ag |
Osteolevin gene polymorphisms
|
|
WO2002043759A2
(en)
|
2000-12-01 |
2002-06-06 |
Wyeth |
Method and composition for modulating bone growth
|
|
EP1357828A2
(en)
|
2001-01-12 |
2003-11-05 |
University of Medicine and Dentistry of New Jersey |
Bone morphogenetic protein-2 in the treatment and diagnosis of cancer
|
|
CA2465499A1
(en)
|
2001-11-08 |
2003-05-15 |
Merck & Co., Inc. |
Compositions and methods for treating osteoporosis
|
|
EP1504099A4
(en)
|
2001-12-10 |
2006-05-10 |
Nuvelo Inc |
NEW NUCLEIC ACIDS AND POLYPEPTIDES
|
|
GB0130738D0
(en)
|
2001-12-21 |
2002-02-06 |
Serono Internat S A |
Protein
|
|
GB2385052A
(en)
|
2002-02-05 |
2003-08-13 |
Leuven K U Res & Dev |
Treatment of spondyloarthropathies
|
|
US20030186915A1
(en)
|
2002-02-11 |
2003-10-02 |
Yang Pan |
Regulatory polynucleotides and uses thereof
|
|
JP2005253301A
(ja)
|
2002-02-20 |
2005-09-22 |
Taisho Pharmaceut Co Ltd |
骨形成蛋白結合領域を有する蛋白質及びそれをコードする遺伝子
|
|
US7332276B2
(en)
|
2002-03-01 |
2008-02-19 |
Celltech R&D, Inc. |
Methods to increase or decrease bone density
|
|
WO2003087763A2
(en)
|
2002-04-03 |
2003-10-23 |
Celltech R & D, Inc. |
Association of polymorphisms in the sost gene region with bone mineral density
|
|
TW200638946A
(en)
|
2002-05-17 |
2006-11-16 |
Wyeth Corp |
Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins
|
|
US20040023356A1
(en)
|
2002-06-14 |
2004-02-05 |
Robb Krumlauf |
Wise/Sost nucleic acid sequences and amino acid sequences
|
|
JP2006513159A
(ja)
|
2002-11-01 |
2006-04-20 |
メルク エンド カムパニー インコーポレーテッド |
アンドロゲン受容体モジュレーターとしてのカルボニルアミノ−ベンズイミダゾール誘導体
|
|
US20060276385A1
(en)
|
2003-01-13 |
2006-12-07 |
Hanjoong Jo |
Anti-inflammatory agents and methods of their use
|
|
PT1608399E
(pt)
|
2003-03-14 |
2012-04-13 |
Ucb Mfg Inc |
Complexo de esclerostina e noguina ou cordina, e agentes que modulam a formação do referido complexo
|
|
JP4832303B2
(ja)
|
2003-05-07 |
2011-12-07 |
メルク・シャープ・エンド・ドーム・コーポレイション |
アンドロゲン受容体モジュレータおよびこれらの使用
|
|
US7381409B2
(en)
|
2003-06-16 |
2008-06-03 |
Celltech R&D, Inc. |
Antibodies specific for sclerostin and methods of screening and use therefor
|
|
WO2005023311A2
(en)
|
2003-09-11 |
2005-03-17 |
Association Francaise Retinitis Pigmentosa (Afrp) |
Novel targets for the treatment of retina diseases
|
|
US8461155B2
(en)
|
2003-09-22 |
2013-06-11 |
University Of Connecticut |
Sclerostin and the inhibition of WNT signaling and bone formation
|
|
US20080249038A1
(en)
|
2003-10-07 |
2008-10-09 |
Quark Biotech, Inc. |
Bone Morphogenetic Protein (Bmp) 2A and Uses Thereof
|
|
JP2007537297A
(ja)
|
2004-05-14 |
2007-12-20 |
ベイラー カレッジ オブ メディスン |
骨質量を調節するための骨を標的化する部分と結合体化したβアドレナリン薬物
|
|
JP2008509087A
(ja)
|
2004-05-27 |
2008-03-27 |
アクセルロン ファーマ インコーポレーテッド |
Tgf抑制解除因子およびそれに関連する使用方法
|
|
EP1863340A2
(en)
|
2005-03-11 |
2007-12-12 |
Genentech, Inc. |
Gene disruptions, compositions and methods relating thereto
|
|
US7592429B2
(en)
|
2005-05-03 |
2009-09-22 |
Ucb Sa |
Sclerostin-binding antibody
|
|
US8003108B2
(en)
|
2005-05-03 |
2011-08-23 |
Amgen Inc. |
Sclerostin epitopes
|
|
US20060293667A1
(en)
|
2005-05-19 |
2006-12-28 |
Agnes Vignery |
Bone implant device and methods of using same
|
|
WO2006135734A2
(en)
|
2005-06-10 |
2006-12-21 |
The Regents Of The University Of California |
Compositions and methods for altering bone density and bone patterning
|
|
US8541177B2
(en)
|
2006-01-13 |
2013-09-24 |
A Chan Holding B.V. |
Treatment and diagnosis of abnormal bone density with an inhibitor of the glypican-sclerostin interaction
|
|
WO2008061013A2
(en)
|
2006-11-10 |
2008-05-22 |
Amgen Inc. |
Antibody-based diagnostics and therapeutics
|
|
EP2460828A3
(en)
|
2006-11-10 |
2012-08-08 |
UCB Pharma, S.A. |
Antibodies and diagnostics
|
|
FI3345607T3
(fi)
|
2006-12-29 |
2022-11-30 |
|
Menetelmiä luun kasvun muuttamiseksi antamalla SOST- tai WISE-antagonistia tai antagonistia
|
|
CL2008002775A1
(es)
|
2007-09-17 |
2008-11-07 |
Amgen Inc |
Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
|
|
TWI489993B
(zh)
*
|
2007-10-12 |
2015-07-01 |
Novartis Ag |
骨硬化素(sclerostin)抗體組合物及使用方法
|
|
JP2011506483A
(ja)
|
2007-12-14 |
2011-03-03 |
アムジエン・インコーポレーテツド |
抗スクレロスチン抗体を用いた骨折の治療方法
|
|
AR075715A1
(es)
*
|
2009-03-05 |
2011-04-20 |
Novartis Ag |
Formulacion de anticuerpo liofilizado
|
|
WO2010115932A1
(en)
|
2009-04-08 |
2010-10-14 |
Novartis Ag |
Combination for the treatment of bone loss
|
|
SMT202000095T1
(it)
|
2010-05-14 |
2020-03-13 |
Amgen Inc |
Formulazioni di anticorpi anti-sclerostina ad alta concentrazione
|
|
US9617323B2
(en)
|
2010-06-07 |
2017-04-11 |
Joshua Rabbani |
Sulfonated sclerostin, antibodies, epitopes and methods for identification and use therefor
|
|
TWI636993B
(zh)
|
2010-10-27 |
2018-10-01 |
安美基公司 |
Dkk1抗體及使用方法
|
|
EP2681242B1
(en)
|
2011-03-01 |
2018-01-24 |
Amgen Inc. |
Sclerostin and dkk-1 bispecific binding agents
|
|
EP2688910B1
(en)
|
2011-03-25 |
2019-05-29 |
Amgen Inc. |
Anti-sclerostin antibody crystals and formulations thereof
|
|
RS57877B1
(sr)
|
2011-04-19 |
2018-12-31 |
Amgen Inc |
Metoda za lečenje osteoporoze
|
|
SI2739311T1
(en)
|
2011-08-04 |
2018-07-31 |
Amgen Inc. |
Method for the treatment of bone defect defects
|
|
EP2797953B1
(en)
|
2011-12-28 |
2020-06-03 |
Amgen Inc. |
Method of treating alveolar bone loss through the use of anti-sclerostin antibodies
|
|
US9925260B2
(en)
|
2012-07-05 |
2018-03-27 |
Ucb Pharma S.A. |
Treatment for bone diseases
|
|
UY35148A
(es)
|
2012-11-21 |
2014-05-30 |
Amgen Inc |
Immunoglobulinas heterodiméricas
|
|
WO2014144817A2
(en)
|
2013-03-15 |
2014-09-18 |
Amgen Inc. |
Inhibitory polypeptides specific to wnt inhibitors
|
|
WO2015087187A1
(en)
|
2013-12-10 |
2015-06-18 |
Rinat Neuroscience Corp. |
Anti-sclerostin antibodies
|
|
MA41142A
(fr)
|
2014-12-12 |
2017-10-17 |
Amgen Inc |
Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
|
|
MA42613A
(fr)
|
2015-08-13 |
2018-06-20 |
Amgen Inc |
Filtration en profondeur chargée de protéines de liaison à un antigène
|
|
GB201604124D0
(en)
|
2016-03-10 |
2016-04-27 |
Ucb Biopharma Sprl |
Pharmaceutical formulation
|
|
WO2018031454A1
(en)
|
2016-08-08 |
2018-02-15 |
Amgen Inc. |
Method of improving connective tissue attachment using anti-sclerostin antibodies
|
|
US10961305B2
(en)
*
|
2016-12-21 |
2021-03-30 |
Mereo Biopharma 3 Limited |
Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
|
|
MX2019007161A
(es)
|
2016-12-21 |
2020-02-12 |
Mereo Biopharma 3 Ltd |
Uso de anticuerpos anti-esclerostina en el tratamiento de osteogenesis imperfecta.
|
|
AU2018235928B2
(en)
|
2017-03-14 |
2023-09-21 |
Amgen Inc. |
Control of total afucosylated glycoforms of antibodies produced in cell culture
|
|
CA3069392A1
(en)
|
2017-07-27 |
2019-01-31 |
Jiangsu Hengrui Medicine Co., Ltd. |
Sost antibody pharmaceutical composition and uses thereof
|
|
CN119639849A
(zh)
|
2018-03-26 |
2025-03-18 |
美国安进公司 |
细胞培养物中产生的抗体的总去岩藻糖基化糖型
|
|
HRP20260414T1
(hr)
|
2018-03-30 |
2026-05-08 |
Amgen Inc. |
C-terminalne varijante protutijela
|
|
EA202190482A1
(ru)
|
2018-08-10 |
2021-05-25 |
Эмджен Инк. |
Способ получения фармацевтического состава на основе антитела
|