JP2020502218A5 - - Google Patents

Download PDF

Info

Publication number
JP2020502218A5
JP2020502218A5 JP2019533573A JP2019533573A JP2020502218A5 JP 2020502218 A5 JP2020502218 A5 JP 2020502218A5 JP 2019533573 A JP2019533573 A JP 2019533573A JP 2019533573 A JP2019533573 A JP 2019533573A JP 2020502218 A5 JP2020502218 A5 JP 2020502218A5
Authority
JP
Japan
Prior art keywords
amino acid
acid sequence
seq
set forth
sequence set
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019533573A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020502218A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/GB2017/053849 external-priority patent/WO2018115879A1/en
Publication of JP2020502218A publication Critical patent/JP2020502218A/ja
Publication of JP2020502218A5 publication Critical patent/JP2020502218A5/ja
Pending legal-status Critical Current

Links

JP2019533573A 2016-12-21 2017-12-21 骨形成不全症の処置における抗スクレロスチン抗体の使用 Pending JP2020502218A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662437358P 2016-12-21 2016-12-21
US62/437,358 2016-12-21
PCT/GB2017/053849 WO2018115879A1 (en) 2016-12-21 2017-12-21 Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta

Publications (2)

Publication Number Publication Date
JP2020502218A JP2020502218A (ja) 2020-01-23
JP2020502218A5 true JP2020502218A5 (enExample) 2021-02-04

Family

ID=60888539

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019533573A Pending JP2020502218A (ja) 2016-12-21 2017-12-21 骨形成不全症の処置における抗スクレロスチン抗体の使用

Country Status (3)

Country Link
US (3) US10961305B2 (enExample)
JP (1) JP2020502218A (enExample)
WO (1) WO2018115879A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL267430B1 (en) * 2016-12-21 2025-09-01 Mereo Biopharma 3 Ltd Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
JP2020502218A (ja) 2016-12-21 2020-01-23 メレオ バイオファーマ 3 リミテッド 骨形成不全症の処置における抗スクレロスチン抗体の使用
MX2024003828A (es) * 2021-09-30 2024-05-10 Mereo Biopharma 3 Ltd Métodos de uso de anticuerpos antiesclerostina en el tratamiento de osteogénesis imperfecta.
WO2025036493A1 (en) * 2023-08-17 2025-02-20 Sinomab Bioscience Limited Antibodies targeting rankl and sclerostin and uses thereof

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4475196A (en) 1981-03-06 1984-10-02 Zor Clair G Instrument for locating faults in aircraft passenger reading light and attendant call control system
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4486194A (en) 1983-06-08 1984-12-04 James Ferrara Therapeutic device for administering medicaments through the skin
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
SE8804164A0 (sv) 1988-11-17 1990-05-18 Per Prisell Farmaceutisk beredning
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5177197A (en) 1990-02-27 1993-01-05 Ludwig Institute For Cancer Research Isolated nucleotide sequence expressing human transforming growth factor-β1-binding protein
US5229495A (en) 1991-06-18 1993-07-20 Ludwig Institute For Cancer Research Substantially pure receptor like TGF-β 1 binding molecules and uses thereof
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
WO1994005800A1 (en) 1992-09-03 1994-03-17 The Regents Of The University Of California Dorsal tissue affecting factor and compositions
US5453492A (en) 1993-07-28 1995-09-26 La Jolla Cancer Research Foundation 60 kDa transforming growth factor-β-binding protein and its use to detect or purify TGF-β
CA2189340A1 (en) 1994-05-04 1995-11-16 James W. Dennis Modulators of cytokines of the tgf-.beta. superfamily and methods for assaying for same
US5616561A (en) 1995-03-31 1997-04-01 Regents Of The University Of California TGF-β antagonists as mitigators of radiation-induced tissue damage
US6610510B1 (en) 1997-04-29 2003-08-26 Regeneron Pharmaceuticals, Inc. Morphogenic proteins
IL133316A0 (en) 1997-06-06 2001-04-30 Regeneron Pharma Ntn-2 member of tnf ligand family
US5935852A (en) 1997-07-03 1999-08-10 Genetics Institute, Inc. DNA molecules encoding mammalian cerberus-like proteins
WO1999061044A1 (en) 1998-05-28 1999-12-02 The Board Of Trustees Of The University Of Arkansas Noggin and antagonists of bone morphogenetic proteins to suppress pathologic bone resorption
WO2000022909A2 (en) 1998-10-19 2000-04-27 Biotech Australia Pty. Limited Systems for oral delivery
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
EP1721979B1 (en) 1998-11-27 2010-09-15 Ucb, S.A. Compositions and methods for increasing bone mineralisation
AU3511100A (en) 1999-03-12 2000-10-04 Regeneron Pharmaceuticals, Inc. Novel nucleic acids and polypeptides
US7358056B1 (en) 1999-08-30 2008-04-15 Signal Pharmaceuticals Methods for modulating signal transduction mediated by TGF-β and related proteins
CA2395926A1 (en) 1999-12-28 2001-07-05 Curagen Corporation Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
AU2001236519A1 (en) 2000-01-24 2001-07-31 Millennium Pharmaceuitcals, Inc. Identification, assessment, prevention, and therapy of prostate cancer
AU2001229508A1 (en) 2000-01-31 2001-08-07 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
EP1290217A2 (en) 2000-02-04 2003-03-12 Aeomica, Inc. Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
IL152785A0 (en) 2000-05-12 2003-06-24 Univ Utah Res Found Compositions and methods for cell dedifferentiation and tissue regeneration
US20040087016A1 (en) 2000-05-12 2004-05-06 University Of Utah Research Foundation Compositions and methods for cell dedifferentiation and tissue regeneration
JP2003534813A (ja) 2000-06-01 2003-11-25 アムジェン インコーポレーテッド シスチンノットポリペプチド:cloaked−2分子およびその使用
WO2001098491A2 (en) 2000-06-19 2001-12-27 F. Hoffmann-La Roche Ag Osteolevin gene polymorphisms
AU2002236558A1 (en) 2000-12-01 2002-06-11 Regents Of The University Of California Method and composition for modulating bone growth
US20020159986A1 (en) 2001-01-12 2002-10-31 John Langenfeld Bone morphogenetic protein-2 in the treatment and diagnosis of cancer
US20040235728A1 (en) 2001-11-08 2004-11-25 Stoch Selwyn Aubrey Compositions and methods for treating osteoporosis
EP1504099A4 (en) 2001-12-10 2006-05-10 Nuvelo Inc NEW NUCLEIC ACIDS AND POLYPEPTIDES
GB0130738D0 (en) 2001-12-21 2002-02-06 Serono Internat S A Protein
GB2385052A (en) 2002-02-05 2003-08-13 Leuven K U Res & Dev Treatment of spondyloarthropathies
US20030186915A1 (en) 2002-02-11 2003-10-02 Yang Pan Regulatory polynucleotides and uses thereof
JP2005253301A (ja) 2002-02-20 2005-09-22 Taisho Pharmaceut Co Ltd 骨形成蛋白結合領域を有する蛋白質及びそれをコードする遺伝子
CA2476410C (en) 2002-03-01 2013-09-24 Celltech R & D, Inc. Methods to increase or decrease bone density
WO2003087763A2 (en) 2002-04-03 2003-10-23 Celltech R & D, Inc. Association of polymorphisms in the sost gene region with bone mineral density
AU2003228958C1 (en) 2002-05-17 2009-01-08 Fidia Advanced Biopolymers, S.R.L. Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins
AU2003276430A1 (en) 2002-06-14 2003-12-31 Stowers Institute For Medical Research Wise/sost nucleic acid sequences and amino acid sequences
JP2006513159A (ja) 2002-11-01 2006-04-20 メルク エンド カムパニー インコーポレーテッド アンドロゲン受容体モジュレーターとしてのカルボニルアミノ−ベンズイミダゾール誘導体
WO2004062621A2 (en) 2003-01-13 2004-07-29 Georgia Tech Research Corporation Anti-inflammatory agents and methods of their use
PL1608399T3 (pl) 2003-03-14 2012-09-28 Ucb Mfg Inc Kompleks sklerostyny i nogginy lub chordyny, oraz czynniki modulujące tworzenie tego kompleksu
US7351698B2 (en) 2003-05-07 2008-04-01 Merck & Co., Inc. Androgen receptor modulators and methods of use thereof
NO345763B1 (no) 2003-06-16 2021-07-19 Celltech R&D Inc Immunogen og antistoffer spesifikke for sklerostin, samt farmasøytiske preparater for å øke benmineralisering.
AU2004269920A1 (en) 2003-09-11 2005-03-17 Association Francaise Retinitis Pigmentosa (Afrp) Novel targets for the treatment of retina diseases
US8461155B2 (en) 2003-09-22 2013-06-11 University Of Connecticut Sclerostin and the inhibition of WNT signaling and bone formation
EP1670425A4 (en) 2003-10-07 2008-04-16 Quark Pharmaceuticals Inc BONE MORPHOGENETIC PROTEIN (BMP) 2A AND ITS APPLICATIONS
EP1758613A2 (en) 2004-05-14 2007-03-07 Baylor College Of Medicine Compositions and methods for modulating bone mass
WO2005118636A2 (en) 2004-05-27 2005-12-15 Acceleron Pharma Inc. Tgf derepressors and uses related thereto
EP1863340A2 (en) 2005-03-11 2007-12-12 Genentech, Inc. Gene disruptions, compositions and methods relating thereto
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
US7592429B2 (en) * 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
US20060293667A1 (en) 2005-05-19 2006-12-28 Agnes Vignery Bone implant device and methods of using same
WO2006135734A2 (en) 2005-06-10 2006-12-21 The Regents Of The University Of California Compositions and methods for altering bone density and bone patterning
US8541177B2 (en) 2006-01-13 2013-09-24 A Chan Holding B.V. Treatment and diagnosis of abnormal bone density with an inhibitor of the glypican-sclerostin interaction
EP2423226A3 (en) 2006-11-10 2012-05-30 Amgen Inc. Antibody-based diagnostics and therapeutics
WO2008133722A2 (en) 2006-11-10 2008-11-06 Ucb Pharma S.A. Anti human sclerostin antibodies
PL3345607T3 (pl) 2006-12-29 2023-01-09 Ossifi-Mab Llc Sposoby modyfikowania wzrostu kości poprzez podanie antagonisty lub agonisty sost lub wise
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
TWI489993B (zh) 2007-10-12 2015-07-01 Novartis Ag 骨硬化素(sclerostin)抗體組合物及使用方法
MX2010006519A (es) 2007-12-14 2010-10-15 Amgen Inc Metodo para tratar una fractura de hueso con anticuerpos anti-esclerostina.
AR075715A1 (es) * 2009-03-05 2011-04-20 Novartis Ag Formulacion de anticuerpo liofilizado
WO2010115932A1 (en) * 2009-04-08 2010-10-14 Novartis Ag Combination for the treatment of bone loss
SMT202000095T1 (it) 2010-05-14 2020-03-13 Amgen Inc Formulazioni di anticorpi anti-sclerostina ad alta concentrazione
US9617323B2 (en) 2010-06-07 2017-04-11 Joshua Rabbani Sulfonated sclerostin, antibodies, epitopes and methods for identification and use therefor
EP2632951B1 (en) 2010-10-27 2017-08-02 Amgen Inc. Dkk1 antibodies and methods of use
MX2013010011A (es) 2011-03-01 2014-10-24 Amgen Inc Agentes de unión biespecífica.
SG193610A1 (en) 2011-03-25 2013-11-29 Amgen Inc Anti - sclerostin antibody crystals and formulations thereof
ES2823240T3 (es) 2011-04-19 2021-05-06 Amgen Inc Método para el tratamiento de la osteoporosis
PT2739311T (pt) 2011-08-04 2018-03-26 Amgen Inc Método para tratamento de defeitos de lacunas ósseas
CN104039828B (zh) 2011-12-28 2017-07-21 安进公司 通过使用抗骨硬化蛋白抗体治疗牙槽骨流失的方法
EP3626267A1 (en) 2012-07-05 2020-03-25 UCB Pharma, S.A. Treatment for bone diseases
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
WO2014144817A2 (en) 2013-03-15 2014-09-18 Amgen Inc. Inhibitory polypeptides specific to wnt inhibitors
WO2015087187A1 (en) 2013-12-10 2015-06-18 Rinat Neuroscience Corp. Anti-sclerostin antibodies
MA41142A (fr) 2014-12-12 2017-10-17 Amgen Inc Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
SG10202101105XA (en) 2015-08-13 2021-03-30 Amgen Inc Charged depth filtration of antigen-binding proteins
GB201604124D0 (en) 2016-03-10 2016-04-27 Ucb Biopharma Sprl Pharmaceutical formulation
MA45921A (fr) 2016-08-08 2019-06-19 Amgen Inc Procédé d'amélioration de la fixation du tissu conjonctif à l'aide d'anticorps anti-sclérostine.
JP2020502218A (ja) * 2016-12-21 2020-01-23 メレオ バイオファーマ 3 リミテッド 骨形成不全症の処置における抗スクレロスチン抗体の使用
IL267430B1 (en) 2016-12-21 2025-09-01 Mereo Biopharma 3 Ltd Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
AU2018235928B2 (en) 2017-03-14 2023-09-21 Amgen Inc. Control of total afucosylated glycoforms of antibodies produced in cell culture
UA127219C2 (uk) 2017-07-27 2023-06-14 Джянгсу Хенгруй Медісін Ко., Лтд. Фармацевтична композиція, що містить анти-sost антитіло, та її застосування
AU2019243848B2 (en) 2018-03-26 2025-01-02 Amgen Inc. Total afucosylated glycoforms of antibodies produced in cell culture
IL316596A (en) 2018-03-30 2024-12-01 Amgen Inc C-terminal antibody variants
IL280642B2 (en) 2018-08-10 2025-09-01 Amgen Inc Method for preparing a pharmaceutical formulation for an antibody

Similar Documents

Publication Publication Date Title
JP2020502219A5 (enExample)
JP2014114288A5 (enExample)
FI3478719T6 (fi) Anti-sklerostiini-vasta-aineiden käyttö synnynnäisen luutumisvajauden hoitamisessa
JP2017160208A5 (enExample)
JP2012525128A5 (enExample)
JP2016535020A5 (enExample)
JP2016537340A5 (enExample)
JP2016528247A5 (enExample)
JP2015525798A5 (enExample)
JP2017500018A5 (enExample)
JP6554155B2 (ja) Il−17アンタゴニストを使用して汎発性膿疱性乾癬(gpp)を処置する方法
JP2020502218A5 (enExample)
RU2017108173A (ru) Комбинированная терапия на основе антител, активирующих человеческий cd40, и антител к человеческому pd-l1
CN103154031A (zh) 利用il-17拮抗剂治疗牛皮癣的方法
JP2016530280A5 (enExample)
CN103189074A (zh) 使用il-17拮抗剂治疗类风湿性关节炎的方法
JP2014514346A5 (enExample)
JP2016515124A5 (enExample)
JP2017160178A5 (enExample)
JP2018515493A5 (enExample)
JP2017536391A (ja) Il−6rアンタゴニストを投与することによってドライアイ疾患を治療するための方法
JP2019532970A5 (enExample)
JP2018529661A5 (enExample)
JP2018512402A5 (enExample)
JP2019519584A5 (enExample)