PL2485761T3 - Sposoby i kompozycje do zwiększania aktywności 2-sulfatazy iduronianu w cns - Google Patents
Sposoby i kompozycje do zwiększania aktywności 2-sulfatazy iduronianu w cnsInfo
- Publication number
- PL2485761T3 PL2485761T3 PL10822810T PL10822810T PL2485761T3 PL 2485761 T3 PL2485761 T3 PL 2485761T3 PL 10822810 T PL10822810 T PL 10822810T PL 10822810 T PL10822810 T PL 10822810T PL 2485761 T3 PL2485761 T3 PL 2485761T3
- Authority
- PL
- Poland
- Prior art keywords
- iduronate
- cns
- compositions
- increasing
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/06—Sulfuric ester hydrolases (3.1.6)
- C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Neurology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25037809P | 2009-10-09 | 2009-10-09 | |
US25604909P | 2009-10-29 | 2009-10-29 | |
EP10822810.7A EP2485761B1 (en) | 2009-10-09 | 2010-10-08 | Methods and compositions for increasing iduronate 2-sulfatase activity in the cns |
PCT/US2010/052113 WO2011044542A1 (en) | 2009-10-09 | 2010-10-08 | Methods and compositions for increasing iduronate 2-sulfatase activity in the cns |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2485761T3 true PL2485761T3 (pl) | 2019-10-31 |
Family
ID=43857180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL10822810T PL2485761T3 (pl) | 2009-10-09 | 2010-10-08 | Sposoby i kompozycje do zwiększania aktywności 2-sulfatazy iduronianu w cns |
Country Status (11)
Country | Link |
---|---|
US (4) | US8834874B2 (pl) |
EP (3) | EP3533467B1 (pl) |
JP (5) | JP2013507131A (pl) |
DK (1) | DK2485761T3 (pl) |
ES (1) | ES2725200T3 (pl) |
HR (1) | HRP20190690T1 (pl) |
HU (1) | HUE044865T2 (pl) |
PL (1) | PL2485761T3 (pl) |
PT (1) | PT2485761T (pl) |
SI (1) | SI2485761T1 (pl) |
WO (1) | WO2011044542A1 (pl) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003222568B2 (en) | 2002-01-11 | 2009-05-07 | Bioasis Technologies, Inc. | Use of P97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes |
US8741260B2 (en) * | 2005-10-07 | 2014-06-03 | Armagen Technologies, Inc. | Fusion proteins for delivery of GDNF to the CNS |
JP5959795B2 (ja) * | 2006-08-18 | 2016-08-02 | アーメイゲン・テクノロジーズ・インコーポレイテッドArmagen Technologies, Inc. | 血液脳関門送達のための物質 |
EP2997976A1 (en) | 2007-07-27 | 2016-03-23 | Armagen Technologies, Inc. | Methods and compositions for increasing alpha-l-iduronidase activity in the cns |
JP5873003B2 (ja) * | 2009-03-18 | 2016-03-01 | アーメイゲン・テクノロジーズ・インコーポレイテッドArmagen Technologies, Inc. | IgGデコイ受容体融合タンパク質の血液脳関門送達のための組成物および方法 |
DK2485761T3 (da) | 2009-10-09 | 2019-05-06 | Armagen Inc | Fremgangsmåder og sammensætninger til øgning af iduronat-2-sulfatase-aktivitet i CNS |
US20160145589A1 (en) | 2011-06-24 | 2016-05-26 | Green Cross Corporation | Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof |
CN103747807B (zh) | 2011-07-05 | 2016-12-07 | 比奥阿赛斯技术有限公司 | P97‑抗体缀合物和使用方法 |
CA2857647C (en) | 2011-12-02 | 2022-04-19 | Armagen Technologies, Inc. | Methods and compositions for increasing arylsulfatase a activity in the cns |
JP2015509091A (ja) | 2012-01-09 | 2015-03-26 | ザ スクリプス リサーチ インスティテュート | ヒト化抗体 |
WO2013106485A2 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
CA2868466A1 (en) | 2012-03-30 | 2013-10-03 | Shire Human Genetic Therapies, Inc. | Subcutaneous administration of iduronate-2-sulfatase |
US9150841B2 (en) * | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
KR101380740B1 (ko) | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
US20140004097A1 (en) * | 2012-06-29 | 2014-01-02 | Shire Human Genetic Therapies, Inc. | Method of producing recombinant iduronate-2-sulfatase |
EP2880156B1 (en) | 2012-07-31 | 2017-08-23 | biOasis Technologies Inc | Dephosphorylated lysosomal storage disease proteins and methods of use thereof |
CA2892763A1 (en) * | 2012-11-30 | 2014-06-05 | Angiochem Inc. | Targeted iduronate-2-sulfatase compounds |
CN105073781A (zh) * | 2013-01-11 | 2015-11-18 | 加州生物医学研究所 | 牛融合抗体 |
WO2014160438A1 (en) | 2013-03-13 | 2014-10-02 | Bioasis Technologies Inc. | Fragments of p97 and uses thereof |
CN111518199A (zh) | 2013-07-18 | 2020-08-11 | 图鲁斯生物科学有限责任公司 | 具有超长互补决定区的人源化抗体 |
JP6692293B2 (ja) * | 2013-07-22 | 2020-05-13 | アーマジェン・インコーポレイテッドArmagen, Inc. | Cnsにおける酵素活性を増大するための方法および組成物 |
EP3038657A2 (en) | 2013-08-28 | 2016-07-06 | Bioasis Technologies Inc. | Cns-targeted conjugates having modified fc regions and methods of use thereof |
EP3088518A4 (en) * | 2013-12-25 | 2017-09-20 | JCR Pharmaceuticals Co., Ltd. | Novel anti-transferrin receptor antibody that passes through blood-brain barrier |
CA2935195A1 (en) | 2014-02-03 | 2015-08-06 | Bioasis Technologies, Inc. | P97 fusion proteins |
DK3107562T3 (da) | 2014-02-19 | 2019-12-16 | Bioasis Technologies Inc | P97-ids-fusionsproteiner |
CN106559993B (zh) * | 2014-03-06 | 2020-12-15 | 加拿大国家研究委员会 | 胰岛素样生长因子1受体特异性抗体及其用途 |
EA035472B1 (ru) * | 2014-03-06 | 2020-06-22 | Нэшнл Рисеч Каунсил Оф Канада | Антитела, специфические к рецептору инсулиноподобного фактора роста 1, и их применения |
EA035517B1 (ru) * | 2014-03-06 | 2020-06-29 | Нэшнл Рисеч Каунсил Оф Канада | Антитела, специфические к рецептору инсулиноподобного фактора роста 1, и их применения |
DE102014205817A1 (de) * | 2014-03-28 | 2015-10-01 | Aktiebolaget Skf | Wälzlagerkäfig und Verfahren zur Montage eines Wälzlagerkäfigs |
US10538589B2 (en) | 2015-01-14 | 2020-01-21 | Armagen Inc. | Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU |
EP3101125A1 (en) * | 2015-06-05 | 2016-12-07 | Laboratorios Del Dr. Esteve, S.A. | Adenoassociated virus vectors for the treatment of mucopolysaccharidoses |
ES2826827T3 (es) | 2015-06-15 | 2021-05-19 | Angiochem Inc | Métodos para el tratamiento de carcinomatosis leptomeníngea |
MY187033A (en) * | 2015-06-24 | 2021-08-27 | Japan Chem Res | Anti-human transferrin receptor antibody permeating blood-brain barrier |
CA2990565A1 (en) | 2015-06-24 | 2016-12-29 | Jcr Pharmaceuticals Co., Ltd. | Fusion protein containing bdnf and anti-human transferrin receptor antibody |
EP3349773A4 (en) | 2015-09-14 | 2019-05-01 | Cincinnati Children's Hospital Medical Center | METHODS AND COMPOSITIONS FOR THE TREATMENT OF LEFT-HALF DISEASE VIA C5A RECEPTOR MODULATION |
RU2673038C2 (ru) * | 2016-01-18 | 2018-11-21 | ООО "Международный Биотехнологический Центр "Генериум" | Лекарственное средство на основе бифункционального антитела для лечения мукополисахаридоза II типа |
WO2018038243A1 (ja) * | 2016-08-25 | 2018-03-01 | Jcrファーマ株式会社 | 抗体融合蛋白質の製造方法 |
BR112019009316A2 (pt) | 2016-12-26 | 2019-08-06 | Japan Chem Res | anticorpo antirreceptor de transferrina humana, proteína de fusão, fragmento de dna, vetor de expressão, célula de mamífero, complexo de composto farmacologicamente ativo e de anticorpo antirreceptor de transferrina humana, usos do anticorpo antirreceptor de transferrina humana e da proteína de fusão, e, métodos para tratamento de um distúrbio do sistema nervoso central e de uma doença do sistema nervoso central que acompanha a doença de pompe, a síndrome de hurler ou a síndrome de hurler-scheie. |
EP3692070A1 (en) | 2017-10-02 | 2020-08-12 | Denali Therapeutics Inc. | Fusion proteins comprising enzyme replacement therapy enzymes |
WO2019143761A1 (en) * | 2018-01-17 | 2019-07-25 | Children's Hospital Medical Center | Compositions and methods for treatment of hunter's syndrome |
WO2019204912A1 (en) * | 2018-04-24 | 2019-10-31 | National Research Council Of Canada | Blood-brain barrier transmigrating therapeutic compounds and uses thereof |
EP3833689A4 (en) * | 2018-08-07 | 2022-05-25 | Armagen, Inc. | METHODS AND COMPOSITIONS FOR INCREASING THE ACTIVITY IN THE CENTRAL NERVOUS SYSTEM OF HEXOSAMINIDASE A, ACID SPHINGOMYELINASE AND PALMITOYL-PROTEIN THIOESTERASE 1 |
KR20200047937A (ko) * | 2018-10-26 | 2020-05-08 | 재단법인 목암생명과학연구소 | Ids를 포함하는 융합 단백질 및 이의 용도 |
WO2020132452A1 (en) | 2018-12-20 | 2020-06-25 | Shire Human Genetic Therapies, Inc. | Purification of iduronate-2-sulfatase immunoglobulin fusion protein |
MX2021011612A (es) * | 2019-04-03 | 2021-12-10 | Denali Therapeutics Inc | Formulaciones de moleculas proteicas que comprenden iduronato 2-sulfatasa. |
CA3128035A1 (en) | 2020-08-13 | 2022-02-13 | Bioasis Technologies, Inc. | Combination therapies for delivery across the blood brain barrier |
EP4265715A1 (en) | 2021-01-12 | 2023-10-25 | JCR Pharmaceuticals Co., Ltd. | Nucleic acid molecule containing incorporated gene encoding fused protein of ligand and protein having physiological activity |
CN118019768A (zh) | 2021-08-18 | 2024-05-10 | 吉尼瑞姆股份公司 | 治疗酶的靶向递送 |
CA3238914A1 (en) | 2021-11-19 | 2023-05-25 | Jcr Pharmaceuticals Co., Ltd. | Peptide having affinity for human transferrin receptor |
Family Cites Families (133)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
US4801575A (en) * | 1986-07-30 | 1989-01-31 | The Regents Of The University Of California | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
US4902505A (en) * | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5180820A (en) * | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
US5229500A (en) * | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
NZ235148A (en) | 1989-09-05 | 1991-12-23 | Immunex Corp | Tumour necrosis factor receptor protein and dna sequences |
US6541610B1 (en) | 1989-09-05 | 2003-04-01 | Immunex Corporation | Fusion proteins comprising tumor necrosis factor receptor |
US5154924A (en) * | 1989-09-07 | 1992-10-13 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
US6329508B1 (en) * | 1989-09-07 | 2001-12-11 | Alkermes, Inc. | Transferrin receptor reactive chimeric antibodies |
US5527527A (en) * | 1989-09-07 | 1996-06-18 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
US5977307A (en) * | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
US5182107A (en) * | 1989-09-07 | 1993-01-26 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates |
US5672683A (en) * | 1989-09-07 | 1997-09-30 | Alkermes, Inc. | Transferrin neuropharmaceutical agent fusion protein |
EP1132471A3 (de) * | 1989-09-12 | 2001-11-28 | F. Hoffmann-La Roche Ag | TNF-bindende Proteine |
US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
TW279133B (pl) | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
US6060069A (en) | 1991-05-20 | 2000-05-09 | Dura Pharmaceuticals, Inc. | Pulmonary delivery of pharmaceuticals |
US6287792B1 (en) * | 1991-06-17 | 2001-09-11 | The Regents Of The University Of California | Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology |
DK0528767T3 (da) * | 1991-08-21 | 2000-04-17 | Novartis Ag | antistofderivater |
HU220795B1 (hu) * | 1991-09-20 | 2002-05-28 | Amgen Inc. | Gliasejtvonal-eredetű neurotróf faktorfehérjék, továbbá berendezések és gyógyászati készítmények idegsejtkárosodás megelőzésére és kezelésére |
JPH06228199A (ja) | 1992-11-27 | 1994-08-16 | Takeda Chem Ind Ltd | 血液脳関門通過可能なペプチド結合体 |
CA2115900A1 (en) | 1993-02-22 | 1994-08-23 | Gerald W. Becker | Pharmaceutical screens and antibodies |
US6195608B1 (en) | 1993-05-28 | 2001-02-27 | Lucent Technologies Inc. | Acoustic highway monitor |
US5997501A (en) | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
EP0706799B1 (en) * | 1994-09-16 | 2001-11-14 | MERCK PATENT GmbH | Immunoconjugates II |
US5656284A (en) | 1995-04-24 | 1997-08-12 | Balkin; Michael S. | Oral transmucosal delivery tablet and method of making it |
AU6163196A (en) * | 1995-06-07 | 1996-12-30 | Smithkline Beecham Corporation | Method for obtaining receptor agonist antibodies |
JP3362394B2 (ja) * | 1995-09-19 | 2003-01-07 | 藤沢薬品工業株式会社 | エアゾール組成物 |
US6015662A (en) * | 1996-01-23 | 2000-01-18 | Abbott Laboratories | Reagents for use as calibrators and controls |
US5837231A (en) * | 1996-06-27 | 1998-11-17 | Regents Of The University Of Minnesota | GM-CSF administration for the treatment and prevention of recurrence of brain tumors |
DE69711188T2 (de) | 1996-07-16 | 2002-09-05 | Nederlanden Staat | Dibenzodihydropyridincarbonsäureester und ihre anwendung in chemolumineszenz-untersuchungsverfahren |
US8173127B2 (en) | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
AU8269898A (en) | 1997-06-27 | 1999-01-19 | Regents Of The University Of California, The | Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor |
WO1999000951A1 (en) | 1997-06-30 | 1999-01-07 | Motorola Inc. | Circuit and packet switched network interconnection |
US6165476A (en) | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
US6482923B1 (en) | 1997-09-17 | 2002-11-19 | Human Genome Sciences, Inc. | Interleukin 17-like receptor protein |
US6165783A (en) * | 1997-10-24 | 2000-12-26 | Neuro Spheres Holdings Ltd. | Erythropoietin-mediated neurogenesis |
US6016800A (en) | 1997-10-24 | 2000-01-25 | Century; Theodore J. | Intrapulmonary aerosolizer |
US6743427B1 (en) * | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
KR100557261B1 (ko) | 1997-12-11 | 2006-03-07 | 알자 코포레이션 | 경피성 작용제 유동률을 증진시키기 위한 장치 |
ATE458007T1 (de) | 1998-04-20 | 2010-03-15 | Glycart Biotechnology Ag | Glykosylierungs-engineering von antikörpern zur verbesserung der antikörperabhängigen zellvermittelten zytotoxizität |
AU760854B2 (en) | 1998-06-22 | 2003-05-22 | Immunomedics Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
US6348210B1 (en) | 1998-11-13 | 2002-02-19 | Alza Corporation | Methods for transdermal drug administration |
US6375975B1 (en) | 1998-12-21 | 2002-04-23 | Generex Pharmaceuticals Incorporated | Pharmaceutical compositions for buccal and pulmonary application |
WO2000037502A2 (en) | 1998-12-22 | 2000-06-29 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists and uses thereof |
US6284262B1 (en) | 1999-01-26 | 2001-09-04 | Virgil A. Place | Compact dosage unit for buccal administration of a pharmacologically active agent |
US7214658B2 (en) * | 2004-07-06 | 2007-05-08 | Tact Ip, Llc | Method of delivering a TNF antagonist to the brain of a human by perispinal administration without direct intrathecal injection |
IL145034A0 (en) | 1999-03-05 | 2002-06-30 | Epigenesis Pharmaceuticals Inc | Method for validating/invalidating target(s) and pathways |
US7309687B1 (en) * | 1999-04-13 | 2007-12-18 | The Kenneth S. Warren Institute, Inc. | Methods for treatment and prevention of neuromuscular and muscular conditions by peripherally administered erythropoietin |
PT1409654E (pt) * | 1999-06-16 | 2008-11-25 | Boston Biomedical Res Inst | Controlo imunológico dos níveis de beta-amilóide in vivo |
CZ299516B6 (cs) * | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
JP3589912B2 (ja) * | 1999-09-03 | 2004-11-17 | 泰久 福井 | ホスファチジルイノシトール−3,4−二リン酸を認識するモノクローナル抗体 |
US20020052311A1 (en) * | 1999-09-03 | 2002-05-02 | Beka Solomon | Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders |
US6195605B1 (en) | 1999-09-29 | 2001-02-27 | Bmi Technologies Inc. | Impact monitor |
US6585971B1 (en) * | 1999-11-12 | 2003-07-01 | Harbor-Ucla Research And Education Institute | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof |
EP2298333A3 (en) | 1999-12-20 | 2012-05-02 | Immunex Corporation | Tweak receptor |
US6248262B1 (en) * | 2000-02-03 | 2001-06-19 | General Electric Company | Carbon-reinforced thermoplastic resin composition and articles made from same |
WO2001064878A2 (en) * | 2000-02-29 | 2001-09-07 | Lexicon Genetics Incorporated | Human transporter proteins and polynucleotides encoding the same |
US6372250B1 (en) * | 2000-04-25 | 2002-04-16 | The Regents Of The University Of California | Non-invasive gene targeting to the brain |
US6696274B2 (en) * | 2000-05-03 | 2004-02-24 | Supratek Pharma, Inc. | Ligand for enhancing oral and CNS delivery of biological agents |
US7078376B1 (en) * | 2000-08-11 | 2006-07-18 | Baxter Healthcare S.A. | Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects |
AU2002246580A1 (en) * | 2000-12-04 | 2002-07-24 | The Regents Of The University Of California | Antisense imaging of gene expression of the brain in vivo |
PT1471871E (pt) * | 2001-02-02 | 2007-06-05 | Ortho Mcneil Pharm Inc | Tratamento de disfunção neurológica compreendendo sulfamatos de frutopiranose e eritropoietina |
MXPA03007005A (es) * | 2001-02-06 | 2003-11-18 | Merck Patent Gmbh | Factor neutrofico derivado del cerebro (bdnf) humano modificado con unmunogenicidad reducida. |
US8163289B2 (en) | 2001-03-09 | 2012-04-24 | Iterative Therapeutics, Inc. | Methods and compositions involving polymeric immunoglobulin fusion proteins |
EP2147679B1 (en) * | 2001-07-25 | 2014-06-25 | Raptor Pharmaceutical, Inc. | Compositions for blood-brain barrier transport |
ES2391905T3 (es) * | 2001-08-17 | 2012-11-30 | Washington University | Método de ensayo para la enfermedad de alzheimer |
US7125843B2 (en) | 2001-10-19 | 2006-10-24 | Neose Technologies, Inc. | Glycoconjugates including more than one peptide |
US7053202B2 (en) * | 2001-10-19 | 2006-05-30 | Millennium Pharmaceuticals, Inc. | Immunoglobulin DNA cassette molecules, monobody constructs, methods of production, and methods of use therefor |
DE60305919T2 (de) | 2002-06-28 | 2007-01-18 | Domantis Limited, Cambridge | Dual-specifische liganden mit erhöhter halbwertszeit |
US20050142141A1 (en) * | 2002-11-27 | 2005-06-30 | Pardridge William M. | Delivery of enzymes to the brain |
US7388079B2 (en) * | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
US20040102369A1 (en) * | 2002-11-27 | 2004-05-27 | The Regents Of The University Of California | Transport of basic fibroblast growth factor across the blood brain barrier |
WO2004072275A2 (en) * | 2003-02-11 | 2004-08-26 | Transkaryotic Therapies, Inc. | Diagnosis and treatment of multiple sulfatase deficiency and other using a formylglycine generating enzyme (fge) |
WO2004108071A2 (en) | 2003-06-05 | 2004-12-16 | Salk Institute For Biological Studies | Targeting polypeptides to the central nervous system |
US20050026823A1 (en) | 2003-06-20 | 2005-02-03 | Biomarin Pharmaceutical Inc. | Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues |
US20050163782A1 (en) | 2003-06-27 | 2005-07-28 | Biogen Idec Ma Inc. | Modified binding molecules comprising connecting peptides |
US7112299B2 (en) | 2003-07-09 | 2006-09-26 | Michael Merrick | Systems and methods for fabricating composite fiberglass laminate articles |
US7294704B2 (en) * | 2003-08-15 | 2007-11-13 | Diadexus, Inc. | Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk |
EP1548031A1 (en) * | 2003-12-22 | 2005-06-29 | Dubai Genetics FZ-LLC | Nature-identical erythropoietin |
EP1713904B1 (en) * | 2004-01-30 | 2016-06-29 | Shire Pharmaceuticals Ireland Limited | Production and purification of recombinant arylsulfatase a |
US7939490B2 (en) * | 2004-12-13 | 2011-05-10 | University Of Maryland, Baltimore | TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
WO2006074399A2 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
CA2589860A1 (en) * | 2005-01-24 | 2006-08-03 | Amgen Inc. | Humanized anti-amyloid antibody |
US7341720B2 (en) | 2005-04-06 | 2008-03-11 | Genzyme Corporation | Targeting of glycoprotein therapeutics |
EP2177614B1 (en) | 2005-05-02 | 2014-12-31 | Toray Industries, Inc. | Composition and method for diagnosing esophageal cancer and metastasis of esophageal cancer |
KR101566393B1 (ko) | 2005-08-03 | 2015-11-05 | 이뮤노젠 아이엔씨 | 면역접합체 제형 |
EP1937720B1 (en) | 2005-08-18 | 2014-04-09 | Ramot at Tel-Aviv University Ltd. | Single chain antibodies against beta-amyloid peptide |
WO2007044468A2 (en) | 2005-10-05 | 2007-04-19 | The Cbr Institute For Biomedical Research, Inc. | Method to treat flavivirus infection with sirna |
US8741260B2 (en) | 2005-10-07 | 2014-06-03 | Armagen Technologies, Inc. | Fusion proteins for delivery of GDNF to the CNS |
US8124095B2 (en) * | 2005-10-07 | 2012-02-28 | Armagen Technologies, Inc. | Fusion proteins for delivery of erythropoietin to the CNS |
US8142781B2 (en) * | 2005-10-07 | 2012-03-27 | Armagen Technologies, Inc. | Fusion proteins for blood-brain barrier delivery |
TW200732472A (en) | 2005-10-21 | 2007-09-01 | Hoffmann La Roche | Method for the recombinant expression of a polypeptide |
CA2641070C (en) | 2006-02-06 | 2017-01-03 | Ramot At Tel-Aviv University Ltd. | Enzyme replacement therapy for treating lysosomal storage diseases |
US7981417B2 (en) | 2006-06-07 | 2011-07-19 | Wisconsin Alumni Research Foundation | Blood-brain barrier targeting anti-bodies |
US7744879B2 (en) | 2006-06-07 | 2010-06-29 | Wisconsin Alumni Research Foundation | Blood-brain barrier targeting antibodies |
GB0614780D0 (en) | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
JP5959795B2 (ja) * | 2006-08-18 | 2016-08-02 | アーメイゲン・テクノロジーズ・インコーポレイテッドArmagen Technologies, Inc. | 血液脳関門送達のための物質 |
WO2008051854A2 (en) | 2006-10-20 | 2008-05-02 | Trustees Of Boston University | A tunable genetic switch for regulating gene expression |
EP2120998B1 (en) * | 2006-11-28 | 2013-08-07 | HanAll Biopharma Co., Ltd. | Modified erythropoietin polypeptides and uses thereof for treatment |
EP2167115A2 (en) * | 2007-06-15 | 2010-03-31 | University Of Zurich | Treatment for alzheimer's disease |
EP2997976A1 (en) | 2007-07-27 | 2016-03-23 | Armagen Technologies, Inc. | Methods and compositions for increasing alpha-l-iduronidase activity in the cns |
WO2009070597A2 (en) | 2007-11-26 | 2009-06-04 | Armagen Technologies, Inc. | Fusion proteins for delivery of gdnf to the cns |
MX2011000071A (es) | 2008-07-02 | 2011-05-03 | Emergent Product Dev Seattle | Inmunoterapeuticos de interleucina-6 (il6). |
US20100077498A1 (en) * | 2008-09-11 | 2010-03-25 | Pardridge William M | Compositions and methods for blood-brain barrier delivery in the mouse |
US20100098693A1 (en) * | 2008-10-07 | 2010-04-22 | Pardridge William M | Compositions and methods for blood-brain barrier delivery of organophosphatases |
CN102300987A (zh) | 2008-12-17 | 2011-12-28 | 安吉奥开米公司 | 膜型-1基质金属蛋白抑制剂及其用途 |
JP5873003B2 (ja) | 2009-03-18 | 2016-03-01 | アーメイゲン・テクノロジーズ・インコーポレイテッドArmagen Technologies, Inc. | IgGデコイ受容体融合タンパク質の血液脳関門送達のための組成物および方法 |
SG176628A1 (en) | 2009-06-05 | 2012-01-30 | Link Medicine Corp | Aminopyrrolidinone derivatives and uses thereof |
JP6073133B2 (ja) | 2009-06-24 | 2017-02-01 | クルナ・インコーポレーテッド | 腫瘍壊死因子受容体2(tnfr2)に対する天然アンチセンス転写物の抑制によるtnfr2関連疾患の治療 |
DK2485761T3 (da) * | 2009-10-09 | 2019-05-06 | Armagen Inc | Fremgangsmåder og sammensætninger til øgning af iduronat-2-sulfatase-aktivitet i CNS |
JP6073783B2 (ja) | 2010-06-25 | 2017-02-01 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | ヘパランn−スルファターゼのcns送達のための方法および組成物 |
NZ605871A (en) | 2010-06-25 | 2015-02-27 | Shire Human Genetic Therapies | Treatment of sanfilippo syndrome type b |
DK3103469T3 (en) | 2010-06-25 | 2021-02-22 | Shire Human Genetic Therapies | Indgivelse af terapeutiske midler til centralnervesystemet |
US20120171120A1 (en) | 2010-11-30 | 2012-07-05 | Genentech, Inc. | Low affinity blood brain barrier receptor antibodies and uses therefor |
WO2012085622A1 (en) | 2010-12-22 | 2012-06-28 | Fondazione Telethon | Therapeutic strategies to treat cns pathology in mucopolysaccharidoses |
US8580922B2 (en) | 2011-03-04 | 2013-11-12 | Shire Human Genetic Therapies, Inc. | Peptide linkers for polypeptide compositions and methods for using same |
US20130039888A1 (en) | 2011-06-08 | 2013-02-14 | Nationwide Children's Hospital Inc. | Products and methods for delivery of polynucleotides by adeno-associated virus for lysosomal storage disorders |
EP2723384B1 (en) | 2011-06-22 | 2018-08-29 | The General Hospital Corporation | Treatment of proteinopathies |
EP2764119A2 (en) | 2011-10-05 | 2014-08-13 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
JP6329483B2 (ja) | 2011-10-12 | 2018-05-23 | シナジェバ・バイオファーマ・コーポレイションSynageva Biopharma Corp. | 組換えヒトnagluタンパク質およびその利用 |
CA2857647C (en) | 2011-12-02 | 2022-04-19 | Armagen Technologies, Inc. | Methods and compositions for increasing arylsulfatase a activity in the cns |
EP2854834A4 (en) | 2012-05-30 | 2016-05-18 | Biostrategies LC | PLANT LECTINES AS AN EXCIPIENT OF RELATED MEDICINAL SUBSTANCES IN ANIMAL AND HUMAN CELLS |
EP2880057A4 (en) | 2012-08-02 | 2016-03-23 | Jn Biosciences Llc | MULTIMERIZED FUSION ANTIBODIES OR PROTEINS THROUGH THE MUTATION OF A CYSTEINE AND A PIECE OF TAIL |
WO2014061735A1 (ja) | 2012-10-19 | 2014-04-24 | 国立大学法人徳島大学 | ヒトβ-ヘキソサミニダーゼBの基質特異性を変換し、且つ、プロテアーゼ抵抗性を付与した新規高機能酵素 |
JP6083219B2 (ja) | 2012-12-06 | 2017-02-22 | 富士通セミコンダクター株式会社 | プラズマフラッドガン及びイオン注入装置 |
US20140354655A1 (en) | 2013-06-04 | 2014-12-04 | Qualcomm Mems Technologies, Inc. | Reducing floating node leakage current with a feedback transistor |
WO2015009961A1 (en) | 2013-07-19 | 2015-01-22 | Armagen Technologies, Inc. | Compositions and methods related to structures that cross the blood brain barrier |
JP6692293B2 (ja) | 2013-07-22 | 2020-05-13 | アーマジェン・インコーポレイテッドArmagen, Inc. | Cnsにおける酵素活性を増大するための方法および組成物 |
EP3119892B1 (en) | 2014-03-17 | 2021-03-10 | The Hospital For Sick Children | Beta-hexosaminidase protein variants and associated methods for treating gm2 gangliosdoses |
US10538589B2 (en) | 2015-01-14 | 2020-01-21 | Armagen Inc. | Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU |
-
2010
- 2010-10-08 DK DK10822810.7T patent/DK2485761T3/da active
- 2010-10-08 ES ES10822810T patent/ES2725200T3/es active Active
- 2010-10-08 EP EP19150184.0A patent/EP3533467B1/en active Active
- 2010-10-08 JP JP2012533375A patent/JP2013507131A/ja not_active Withdrawn
- 2010-10-08 EP EP23183395.5A patent/EP4273164A3/en active Pending
- 2010-10-08 HU HUE10822810 patent/HUE044865T2/hu unknown
- 2010-10-08 SI SI201031879T patent/SI2485761T1/sl unknown
- 2010-10-08 WO PCT/US2010/052113 patent/WO2011044542A1/en active Application Filing
- 2010-10-08 PT PT10822810T patent/PT2485761T/pt unknown
- 2010-10-08 PL PL10822810T patent/PL2485761T3/pl unknown
- 2010-10-08 EP EP10822810.7A patent/EP2485761B1/en active Active
- 2010-10-08 US US12/901,481 patent/US8834874B2/en active Active
-
2014
- 2014-06-16 US US14/305,402 patent/US10011651B2/en active Active
-
2016
- 2016-01-28 JP JP2016014716A patent/JP2016155805A/ja active Pending
-
2018
- 2018-05-08 JP JP2018089998A patent/JP2018154629A/ja active Pending
- 2018-05-17 US US15/982,990 patent/US11028156B2/en active Active
-
2019
- 2019-04-12 HR HRP20190690TT patent/HRP20190690T1/hr unknown
-
2020
- 2020-10-01 JP JP2020167101A patent/JP2021008488A/ja active Pending
-
2021
- 2021-04-30 US US17/246,288 patent/US20210253681A1/en active Pending
-
2022
- 2022-12-22 JP JP2022205808A patent/JP2023033321A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2023033321A (ja) | 2023-03-10 |
US20110110935A1 (en) | 2011-05-12 |
US8834874B2 (en) | 2014-09-16 |
US20190185551A2 (en) | 2019-06-20 |
JP2013507131A (ja) | 2013-03-04 |
EP3533467A3 (en) | 2020-01-15 |
US20180251535A1 (en) | 2018-09-06 |
EP4273164A2 (en) | 2023-11-08 |
ES2725200T3 (es) | 2019-09-20 |
EP3533467B1 (en) | 2023-07-26 |
PT2485761T (pt) | 2019-05-30 |
HUE044865T2 (hu) | 2019-11-28 |
EP2485761B1 (en) | 2019-02-27 |
EP2485761A1 (en) | 2012-08-15 |
EP3533467A2 (en) | 2019-09-04 |
US10011651B2 (en) | 2018-07-03 |
EP2485761A4 (en) | 2013-04-03 |
SI2485761T1 (sl) | 2019-05-31 |
US20210253681A1 (en) | 2021-08-19 |
WO2011044542A1 (en) | 2011-04-14 |
JP2018154629A (ja) | 2018-10-04 |
DK2485761T3 (da) | 2019-05-06 |
US11028156B2 (en) | 2021-06-08 |
JP2021008488A (ja) | 2021-01-28 |
JP2016155805A (ja) | 2016-09-01 |
EP4273164A3 (en) | 2024-01-24 |
US20150004160A1 (en) | 2015-01-01 |
HRP20190690T1 (hr) | 2019-06-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT2485761T (pt) | Métodos e composições para aumentar a atividade da iduronato 2-sulfatase no snc | |
HRP20190521T1 (hr) | Novi pripravci za prevenciju i/ili liječenje poremećaja lizosomskog nakupljanja | |
IL262668A (en) | Preparations for the treatment of Gaucher disease | |
HK1219306A1 (zh) | 用於睡眠障礙和其他疾病的方法和組合物 | |
EP2785378A4 (en) | METHODS AND COMPOSITIONS FOR INCREASING ARYLSULFATASE A ACTIVITY IN THE CENTRAL NERVOUS SYSTEM | |
HK1174064A1 (zh) | 用於細胞增殖相關的疾病的方法和組合物 | |
EP2182980A4 (en) | METHOD AND COMPOSITIONS FOR INCREASED ALPHA IDURONIDASE ACTIVITY IN THE CNS | |
EP2406389A4 (en) | METHOD AND COMPOSITIONS FOR CELL-RETENTION-BASED DISEASES | |
EP2510094A4 (en) | COMPOSITIONS AND METHODS WITH PROTEASE VARIANTS | |
PL2451943T3 (pl) | Sposoby i kompozycje do zastosowania w terapiach komórkowych | |
IL218212A0 (en) | Therapeutic methods and compositions | |
IL215583A0 (en) | Methods for preventing and/or treating lysosomal storage disorders | |
SI2437606T1 (sl) | Sestavki in postopki za povečanje telomerazne aktivnosti | |
EP2443144A4 (en) | SAP VARIANTS AND ITS USE | |
EP2205271A4 (en) | COMPOSITIONS AND METHODS OF THERAPIES BASED ON RIBONUCLEASE BASE | |
EP2461870A4 (en) | THERAPEUTIC COMPOSITIONS AND METHOD | |
HK1127254A2 (en) | Protection band used in lighters |