JP2013507131A - Cnsにおけるイズロン酸2−スルファターゼ活性を増加させるための方法および組成物 - Google Patents

Cnsにおけるイズロン酸2−スルファターゼ活性を増加させるための方法および組成物 Download PDF

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JP2013507131A
JP2013507131A JP2012533375A JP2012533375A JP2013507131A JP 2013507131 A JP2013507131 A JP 2013507131A JP 2012533375 A JP2012533375 A JP 2012533375A JP 2012533375 A JP2012533375 A JP 2012533375A JP 2013507131 A JP2013507131 A JP 2013507131A
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amino acid
fusion antibody
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acid sequence
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JP2013507131A5 (enExample
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ウィリアム・エム・パードリッジ
ルーベン・ジェイ・ボアド
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Armagen Inc
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/33Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/06Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06013Iduronate-2-sulfatase (3.1.6.13)

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012533375A 2009-10-09 2010-10-08 Cnsにおけるイズロン酸2−スルファターゼ活性を増加させるための方法および組成物 Withdrawn JP2013507131A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25037809P 2009-10-09 2009-10-09
US61/250,378 2009-10-09
US25604909P 2009-10-29 2009-10-29
US61/256,049 2009-10-29
PCT/US2010/052113 WO2011044542A1 (en) 2009-10-09 2010-10-08 Methods and compositions for increasing iduronate 2-sulfatase activity in the cns

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JP2016014716A Division JP2016155805A (ja) 2009-10-09 2016-01-28 Cnsにおけるイズロン酸2−スルファターゼ活性を増加させるための方法および組成物

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JP2013507131A5 JP2013507131A5 (enExample) 2013-07-25

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JP2012533375A Withdrawn JP2013507131A (ja) 2009-10-09 2010-10-08 Cnsにおけるイズロン酸2−スルファターゼ活性を増加させるための方法および組成物
JP2016014716A Pending JP2016155805A (ja) 2009-10-09 2016-01-28 Cnsにおけるイズロン酸2−スルファターゼ活性を増加させるための方法および組成物
JP2018089998A Pending JP2018154629A (ja) 2009-10-09 2018-05-08 Cnsにおけるイズロン酸 2−スルファターゼ活性を増加させるための方法および組成物
JP2020167101A Pending JP2021008488A (ja) 2009-10-09 2020-10-01 Cnsにおけるイズロン酸 2−スルファターゼ活性を増加させるための方法および組成物
JP2022205808A Pending JP2023033321A (ja) 2009-10-09 2022-12-22 Cnsにおけるイズロン酸 2-スルファターゼ活性を増加させるための方法および組成物

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JP2018089998A Pending JP2018154629A (ja) 2009-10-09 2018-05-08 Cnsにおけるイズロン酸 2−スルファターゼ活性を増加させるための方法および組成物
JP2020167101A Pending JP2021008488A (ja) 2009-10-09 2020-10-01 Cnsにおけるイズロン酸 2−スルファターゼ活性を増加させるための方法および組成物
JP2022205808A Pending JP2023033321A (ja) 2009-10-09 2022-12-22 Cnsにおけるイズロン酸 2-スルファターゼ活性を増加させるための方法および組成物

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EP (3) EP4273164A3 (enExample)
JP (5) JP2013507131A (enExample)
DK (1) DK2485761T3 (enExample)
ES (1) ES2725200T3 (enExample)
HR (1) HRP20190690T1 (enExample)
HU (1) HUE044865T2 (enExample)
PL (1) PL2485761T3 (enExample)
PT (1) PT2485761T (enExample)
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WO (1) WO2011044542A1 (enExample)

Cited By (8)

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WO2015098989A1 (ja) 2013-12-25 2015-07-02 Jcrファーマ株式会社 血液脳関門を通過する新規抗トランスフェリン受容体抗体
JP2016525545A (ja) * 2013-07-22 2016-08-25 アーメイゲン・テクノロジーズ・インコーポレイテッドArmagen Technologies, Inc. Cnsにおける酵素活性を増大するための方法および組成物
JP2016155805A (ja) * 2009-10-09 2016-09-01 アーメイゲン・テクノロジーズ・インコーポレイテッドArmagen Technologies, Inc. Cnsにおけるイズロン酸2−スルファターゼ活性を増加させるための方法および組成物
WO2018038243A1 (ja) * 2016-08-25 2018-03-01 Jcrファーマ株式会社 抗体融合蛋白質の製造方法
JP2021533167A (ja) * 2018-08-07 2021-12-02 アーマジェン・インコーポレイテッドArmagen, Inc. ヘキソサミニダーゼa、酸スフィンゴミエリナーゼおよびパルミトイル−タンパク質チオエステラーゼ1のcnsにおける活性を増加させるための方法および組成物
JP2022512575A (ja) * 2018-10-26 2022-02-07 モガム・インスティテュート・フォー・バイオメディカル・リサーチ Idsを含む融合タンパク質及びその使用
JP2022526799A (ja) * 2019-04-03 2022-05-26 デナリ セラピューティクス インコーポレイテッド イズロン酸2-スルファターゼを含むタンパク質分子の製剤
JP2024532176A (ja) * 2021-08-18 2024-09-05 ジョイント-ストック カンパニー “ジェネリウム” 療法酵素のターゲティング化送達

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