JP2013533268A5 - - Google Patents
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- Publication number
- JP2013533268A5 JP2013533268A5 JP2013520235A JP2013520235A JP2013533268A5 JP 2013533268 A5 JP2013533268 A5 JP 2013533268A5 JP 2013520235 A JP2013520235 A JP 2013520235A JP 2013520235 A JP2013520235 A JP 2013520235A JP 2013533268 A5 JP2013533268 A5 JP 2013533268A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- activation
- enhancing antibody
- antibody against
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 101000852815 Homo sapiens Insulin receptor Proteins 0.000 claims 5
- 102000008299 Nitric Oxide Synthase Human genes 0.000 claims 5
- 108010021487 Nitric Oxide Synthase Proteins 0.000 claims 5
- 230000003511 endothelial effect Effects 0.000 claims 5
- 102000047882 human INSR Human genes 0.000 claims 5
- 238000010790 dilution Methods 0.000 claims 3
- 239000012895 dilution Substances 0.000 claims 3
- 239000002552 dosage form Substances 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 210000004900 c-terminal fragment Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000001632 homeopathic effect Effects 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 102000003746 Insulin Receptor Human genes 0.000 claims 1
- 108010001127 Insulin Receptor Proteins 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010130348/15A RU2531048C2 (ru) | 2010-07-21 | 2010-07-21 | Лекарственное средство для уменьшения резистентности к инсулину и лечения сахарного диабета и способ повышения эффективности лечения сахарного диабета инсулином и/или гипогликемическими препаратами |
| RU2010130348 | 2010-07-21 | ||
| RU2011127051/15A RU2509572C2 (ru) | 2011-07-01 | 2011-07-01 | Лекарственное средство для уменьшения резистентности к инсулину и для лечения сахарного диабета, способ уменьшения резистентности к инсулину, способ лечения сахарного диабета и способ лечения сахарного диабета инсулином и/или гипогликемическими препаратами |
| RU2011127051 | 2011-07-01 | ||
| PCT/IB2011/002177 WO2012010966A2 (en) | 2010-07-21 | 2011-07-15 | A combination pharmaceutical composition and methods of treating diabetes and metabolic disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016131729A Division JP2016222684A (ja) | 2010-07-21 | 2016-07-01 | 糖尿病及び代謝障害を治療する組み合わせ医薬組成物及び方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013533268A JP2013533268A (ja) | 2013-08-22 |
| JP2013533268A5 true JP2013533268A5 (enExample) | 2014-04-24 |
Family
ID=44899155
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013520235A Pending JP2013533268A (ja) | 2010-07-21 | 2011-07-15 | 糖尿病及び代謝障害を治療する組み合わせ医薬組成物及び方法 |
| JP2016131729A Pending JP2016222684A (ja) | 2010-07-21 | 2016-07-01 | 糖尿病及び代謝障害を治療する組み合わせ医薬組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016131729A Pending JP2016222684A (ja) | 2010-07-21 | 2016-07-01 | 糖尿病及び代謝障害を治療する組み合わせ医薬組成物及び方法 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8617555B2 (enExample) |
| EP (2) | EP2595658A2 (enExample) |
| JP (2) | JP2013533268A (enExample) |
| KR (2) | KR20180127515A (enExample) |
| CN (1) | CN103118707A (enExample) |
| AR (1) | AR082312A1 (enExample) |
| AU (1) | AU2011281240B2 (enExample) |
| BR (1) | BR112013001299A2 (enExample) |
| CA (1) | CA2805961A1 (enExample) |
| CL (1) | CL2013000200A1 (enExample) |
| CZ (1) | CZ2013124A3 (enExample) |
| DE (1) | DE112011102396T5 (enExample) |
| DK (1) | DK201370089A (enExample) |
| EA (1) | EA029847B1 (enExample) |
| EE (1) | EE05761B1 (enExample) |
| ES (1) | ES2445846R1 (enExample) |
| FI (1) | FI20135152L (enExample) |
| FR (1) | FR2962913A1 (enExample) |
| GB (2) | GB2552405B (enExample) |
| IT (1) | ITTO20110627A1 (enExample) |
| LT (1) | LT5980B (enExample) |
| MX (1) | MX2013000804A (enExample) |
| MY (1) | MY160979A (enExample) |
| NO (1) | NO20130265A1 (enExample) |
| NZ (1) | NZ606964A (enExample) |
| PE (1) | PE20130815A1 (enExample) |
| PH (1) | PH12013500140A1 (enExample) |
| SE (1) | SE1350212A1 (enExample) |
| SG (1) | SG187578A1 (enExample) |
| WO (1) | WO2012010966A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2181297C2 (ru) * | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Способ лечения патологического синдрома и лекарственное средство |
| UA76638C2 (en) | 2002-08-02 | 2006-08-15 | Oleh Illich Epshtein | Homeopathic medication based on anti-interferon antibodies and method for treating a pathological syndrome associated with interferon |
| RU2309732C1 (ru) * | 2006-03-13 | 2007-11-10 | Олег Ильич Эпштейн | Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата |
| MX2008015621A (es) * | 2006-06-06 | 2009-03-06 | Oleg Iliich Epshtein | Agente medicinal para el tratamiento de obesidad, diabetes y enfermedades relacionadas con la tolerancia deteriorada de glucosa. |
| WO2012017324A2 (en) | 2010-07-15 | 2012-02-09 | Oleg Iliich Epshtein | Combination pharmaceutical composition and methods of treating diseases or conditions associated with neurodegenerative diseases |
| CA2805091A1 (en) | 2010-07-15 | 2012-01-19 | Oleg Iliich Epshtein | Pharmaceutical compositions comprising a homopathically potentized form of an antibody to human cannabinoid receptor |
| PH12013500107A1 (en) * | 2010-07-15 | 2013-03-11 | Oleg Iliich Epshtein | A method of increasing the effect of an activated-potentiated form of an antibody |
| JP2013533269A (ja) | 2010-07-21 | 2013-08-22 | イリイチ・エプシテイン オレグ | 組み合わせ医薬組成物及び呼吸器の疾患又は状態に関連する疾患及び状態を治療する方法 |
| PH12013500144A1 (en) | 2010-07-21 | 2018-03-21 | Oleg Iliich Epshtein | A method of treating attention deficit hyperactivity disorder |
| ITTO20110630A1 (it) * | 2010-07-21 | 2012-01-22 | Oleg Iliich Epshtein | Composizioni farmaceutiche di combinazione e metodo per trattare vertigini, cinetosi e distonia vascolare vegetativa |
| PE20131185A1 (es) * | 2010-08-06 | 2013-10-05 | Materia Medica Holding | Composicion farmaceutica combinada y metodos para el tratamiento y prevencion de las enfermedades infecciosas |
| TWI588153B (zh) * | 2012-05-18 | 2017-06-21 | 中國醫藥大學 | 多胜肽、編碼該多胜肽之核酸分子、以及該多胜肽之應用 |
| RU2013111961A (ru) | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
| RU2013111962A (ru) | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4311897A (en) | 1979-08-28 | 1982-01-19 | Union Carbide Corporation | Plasma arc torch and nozzle assembly |
| US5811437A (en) * | 1996-05-21 | 1998-09-22 | Eli Lilly And Company | Methods of increasing nitric oxide synthesis |
| US6150500A (en) * | 1996-07-12 | 2000-11-21 | Salerno; John C. | Activators of endothelial nitric oxide synthase |
| WO1999026657A1 (en) * | 1997-11-25 | 1999-06-03 | Musc Foundation For Research Development | Inhibitors of nitric oxide synthase |
| US6933272B1 (en) * | 1998-09-22 | 2005-08-23 | Erik Helmerhorst | Use of non-peptidyl compounds for the treatment of insulin related ailments |
| RU2181297C2 (ru) * | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Способ лечения патологического синдрома и лекарственное средство |
| UA76638C2 (en) | 2002-08-02 | 2006-08-15 | Oleh Illich Epshtein | Homeopathic medication based on anti-interferon antibodies and method for treating a pathological syndrome associated with interferon |
| UA76639C2 (uk) | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Гомеопатичний лікарський засіб та спосіб лікування еректильних дисфункцій |
| UA76641C2 (uk) | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Гомеопатичний лікарський засіб та спосіб лікування захворювань передміхурової залози |
| US20040097467A1 (en) * | 2002-08-22 | 2004-05-20 | Vijaya Juturu | Arginine silicate inositol complex and use thereof |
| WO2004082597A2 (en) | 2003-03-14 | 2004-09-30 | Nutrition Research, Inc. | Homeopathic formulations useful for treating pain and/or inflammmation |
| JP2007518692A (ja) * | 2004-01-20 | 2007-07-12 | アステラス製薬株式会社 | 勃起不全治療方法 |
| RU2438707C2 (ru) * | 2006-06-06 | 2012-01-10 | Олег Ильич Эпштейн | Лекарственное средство для перорального лечения сахарного диабета и других заболеваний, сопровождающихся нарушением толерантности к глюкозе, и способ получения твердой лекарственной формы для пероральной терапии сахарного диабета и других заболеваний, сопровождающихся нарушением толерантности к глюкозе |
| MX2008015621A (es) * | 2006-06-06 | 2009-03-06 | Oleg Iliich Epshtein | Agente medicinal para el tratamiento de obesidad, diabetes y enfermedades relacionadas con la tolerancia deteriorada de glucosa. |
| GB0812019D0 (en) * | 2008-07-02 | 2008-08-06 | Asterion Ltd | Insulin |
| CA2805091A1 (en) * | 2010-07-15 | 2012-01-19 | Oleg Iliich Epshtein | Pharmaceutical compositions comprising a homopathically potentized form of an antibody to human cannabinoid receptor |
| WO2012017324A2 (en) * | 2010-07-15 | 2012-02-09 | Oleg Iliich Epshtein | Combination pharmaceutical composition and methods of treating diseases or conditions associated with neurodegenerative diseases |
| PH12013500107A1 (en) * | 2010-07-15 | 2013-03-11 | Oleg Iliich Epshtein | A method of increasing the effect of an activated-potentiated form of an antibody |
| JP2013533269A (ja) * | 2010-07-21 | 2013-08-22 | イリイチ・エプシテイン オレグ | 組み合わせ医薬組成物及び呼吸器の疾患又は状態に関連する疾患及び状態を治療する方法 |
| ITTO20110630A1 (it) * | 2010-07-21 | 2012-01-22 | Oleg Iliich Epshtein | Composizioni farmaceutiche di combinazione e metodo per trattare vertigini, cinetosi e distonia vascolare vegetativa |
-
2011
- 2011-07-15 CZ CZ20130124A patent/CZ2013124A3/cs unknown
- 2011-07-15 PE PE2013000114A patent/PE20130815A1/es not_active Application Discontinuation
- 2011-07-15 US US13/135,891 patent/US8617555B2/en active Active
- 2011-07-15 MX MX2013000804A patent/MX2013000804A/es active IP Right Grant
- 2011-07-15 AU AU2011281240A patent/AU2011281240B2/en not_active Ceased
- 2011-07-15 EP EP11773314.7A patent/EP2595658A2/en not_active Ceased
- 2011-07-15 KR KR1020187032943A patent/KR20180127515A/ko not_active Ceased
- 2011-07-15 EE EEP201300007A patent/EE05761B1/et not_active IP Right Cessation
- 2011-07-15 EP EP19213849.3A patent/EP3693018A1/en not_active Withdrawn
- 2011-07-15 CN CN2011800454899A patent/CN103118707A/zh active Pending
- 2011-07-15 SG SG2013004817A patent/SG187578A1/en unknown
- 2011-07-15 EA EA201300124A patent/EA029847B1/ru not_active IP Right Cessation
- 2011-07-15 DE DE112011102396T patent/DE112011102396T5/de not_active Withdrawn
- 2011-07-15 PH PH1/2013/500140A patent/PH12013500140A1/en unknown
- 2011-07-15 IT IT000627A patent/ITTO20110627A1/it unknown
- 2011-07-15 FI FI20135152A patent/FI20135152L/fi not_active Application Discontinuation
- 2011-07-15 JP JP2013520235A patent/JP2013533268A/ja active Pending
- 2011-07-15 SE SE1350212A patent/SE1350212A1/sv unknown
- 2011-07-15 FR FR1156480A patent/FR2962913A1/fr not_active Withdrawn
- 2011-07-15 WO PCT/IB2011/002177 patent/WO2012010966A2/en not_active Ceased
- 2011-07-15 NZ NZ606964A patent/NZ606964A/en not_active IP Right Cessation
- 2011-07-15 KR KR1020137004330A patent/KR20130103486A/ko not_active Ceased
- 2011-07-15 CA CA2805961A patent/CA2805961A1/en not_active Abandoned
- 2011-07-15 MY MYPI2013000225A patent/MY160979A/en unknown
- 2011-07-15 BR BR112013001299A patent/BR112013001299A2/pt not_active Application Discontinuation
- 2011-07-15 ES ES201390009A patent/ES2445846R1/es active Pending
- 2011-07-15 GB GB1707872.6A patent/GB2552405B/en not_active Expired - Fee Related
- 2011-07-15 GB GB1302924.4A patent/GB2496799B/en not_active Expired - Fee Related
- 2011-07-21 AR ARP110102642A patent/AR082312A1/es not_active Application Discontinuation
-
2013
- 2013-01-21 CL CL2013000200A patent/CL2013000200A1/es unknown
- 2013-02-18 NO NO20130265A patent/NO20130265A1/no not_active Application Discontinuation
- 2013-02-19 LT LT2013018A patent/LT5980B/lt not_active IP Right Cessation
- 2013-02-19 DK DKPA201370089A patent/DK201370089A/da not_active Application Discontinuation
-
2016
- 2016-07-01 JP JP2016131729A patent/JP2016222684A/ja active Pending
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