ES2445846R1 - Una composición de combinación farmacéutica y su uso para preparar un medicamento destinado al tatamiento de la diabetes de tipo l y los trastornos metabólicos - Google Patents
Una composición de combinación farmacéutica y su uso para preparar un medicamento destinado al tatamiento de la diabetes de tipo l y los trastornos metabólicos Download PDFInfo
- Publication number
- ES2445846R1 ES2445846R1 ES201390009A ES201390009A ES2445846R1 ES 2445846 R1 ES2445846 R1 ES 2445846R1 ES 201390009 A ES201390009 A ES 201390009A ES 201390009 A ES201390009 A ES 201390009A ES 2445846 R1 ES2445846 R1 ES 2445846R1
- Authority
- ES
- Spain
- Prior art keywords
- diabetes
- medicament
- prepare
- treatment
- metabolic disorders
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 208000030159 metabolic disease Diseases 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 title abstract 2
- 101000852815 Homo sapiens Insulin receptor Proteins 0.000 abstract 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000003511 endothelial effect Effects 0.000 abstract 1
- 102000047882 human INSR Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0004—Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una composición de combinación farmacéutica y su uso para preparar un medicamento destinado al tratamiento de la diabetes de tipo I y los trastornos metabólicos. La presente solicitud proporciona una composición farmacéutica para ser usada para preparar un medicamento destinado al tratamiento de la diabetes y otros trastornos metabólicos. La composición comprende a) una forma activada potenciada de un anticuerpo contra el receptor de la insulina humana, y b) una forma activada potenciada de un anticuerpo para la NO sintasa endotelial.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2010130348/15A RU2531048C2 (ru) | 2010-07-21 | 2010-07-21 | Лекарственное средство для уменьшения резистентности к инсулину и лечения сахарного диабета и способ повышения эффективности лечения сахарного диабета инсулином и/или гипогликемическими препаратами |
RU2010130348 | 2010-07-21 | ||
RU2011127051 | 2011-07-01 | ||
RU2011127051/15A RU2509572C2 (ru) | 2011-07-01 | 2011-07-01 | Лекарственное средство для уменьшения резистентности к инсулину и для лечения сахарного диабета, способ уменьшения резистентности к инсулину, способ лечения сахарного диабета и способ лечения сахарного диабета инсулином и/или гипогликемическими препаратами |
PCT/IB2011/002177 WO2012010966A2 (en) | 2010-07-21 | 2011-07-15 | A combination pharmaceutical composition and methods of treating diabetes and metabolic disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2445846A2 ES2445846A2 (es) | 2014-03-05 |
ES2445846R1 true ES2445846R1 (es) | 2015-01-02 |
Family
ID=44899155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES201390009A Pending ES2445846R1 (es) | 2010-07-21 | 2011-07-15 | Una composición de combinación farmacéutica y su uso para preparar un medicamento destinado al tatamiento de la diabetes de tipo l y los trastornos metabólicos |
Country Status (29)
Country | Link |
---|---|
US (1) | US8617555B2 (es) |
EP (2) | EP2595658A2 (es) |
JP (2) | JP2013533268A (es) |
KR (2) | KR20180127515A (es) |
CN (1) | CN103118707A (es) |
AR (1) | AR082312A1 (es) |
AU (1) | AU2011281240B2 (es) |
BR (1) | BR112013001299A2 (es) |
CA (1) | CA2805961A1 (es) |
CL (1) | CL2013000200A1 (es) |
CZ (1) | CZ2013124A3 (es) |
DE (1) | DE112011102396T5 (es) |
DK (1) | DK201370089A (es) |
EA (1) | EA029847B1 (es) |
EE (1) | EE05761B1 (es) |
ES (1) | ES2445846R1 (es) |
FI (1) | FI20135152L (es) |
FR (1) | FR2962913A1 (es) |
GB (2) | GB2496799B (es) |
IT (1) | ITTO20110627A1 (es) |
LT (1) | LT5980B (es) |
MX (1) | MX2013000804A (es) |
MY (1) | MY160979A (es) |
NO (1) | NO20130265A1 (es) |
NZ (1) | NZ606964A (es) |
PE (1) | PE20130815A1 (es) |
SE (1) | SE1350212A1 (es) |
SG (1) | SG187578A1 (es) |
WO (1) | WO2012010966A2 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2181297C2 (ru) * | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Способ лечения патологического синдрома и лекарственное средство |
UA76638C2 (en) | 2002-08-02 | 2006-08-15 | Oleh Illich Epshtein | Homeopathic medication based on anti-interferon antibodies and method for treating a pathological syndrome associated with interferon |
RU2309732C1 (ru) * | 2006-03-13 | 2007-11-10 | Олег Ильич Эпштейн | Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата |
EA200802440A1 (ru) * | 2006-06-06 | 2009-06-30 | Олег Ильич ЭПШТЕЙН | Лекарственное средство для лечения ожирения, сахарного диабета и заболеваний с нарушением толерантности к глюкозе |
JP2013532182A (ja) | 2010-07-15 | 2013-08-15 | イリイチ・エプシテイン オレグ | 組み合わせ医薬組成物及び神経変性疾患に関連する疾患又は状態を治療する方法 |
US9308275B2 (en) * | 2010-07-15 | 2016-04-12 | Oleg Iliich Epshtein | Method of increasing the effect of an activated-potentiated form of an antibody |
EP2593477A2 (en) | 2010-07-15 | 2013-05-22 | Oleg Iliich Epshtein | Pharmaceutical compositions and methods of treatment |
GB2496343B (en) | 2010-07-21 | 2017-11-01 | Iliich Epshtein Oleg | A method of treating attention deficit hyperactivity disorder |
ES2425315R1 (es) * | 2010-07-21 | 2014-09-08 | Oleg Iliich Epshtein | Composición farmacéutica y su uso para preparar un medicamento destinado al tratamiento sintomático de una enfermedad o afección respiratoria |
KR20130102542A (ko) * | 2010-07-21 | 2013-09-17 | 올레그 일리치 엡쉬테인 | 현기증, 동요병 및 증식형-혈관 이긴장증 치료용 제약학적 복합 조성물 및 치료 방법들 |
BR112013002296A2 (pt) * | 2010-08-06 | 2018-01-30 | Lliich Epshtein Oleg | composição farmacêutica e respectivo uso e método para tratar doença infecciosa |
TWI588153B (zh) | 2012-05-18 | 2017-06-21 | 中國醫藥大學 | 多胜肽、編碼該多胜肽之核酸分子、以及該多胜肽之應用 |
RU2013111961A (ru) | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
RU2013111962A (ru) | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998002555A1 (en) * | 1996-07-12 | 1998-01-22 | Salerno John C | Applications for regulatory region of nos isoforms |
EP2036574A1 (en) * | 2006-06-06 | 2009-03-18 | Oleg Iliich Epshtein | Medicinal agent for treating fatness, diabetes, and diseases associated with impaired glucose tolerance |
US20100166762A1 (en) * | 2000-06-20 | 2010-07-01 | Oleg Iliich Epshtein | Method of treating a pathological syndrome |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4311897A (en) | 1979-08-28 | 1982-01-19 | Union Carbide Corporation | Plasma arc torch and nozzle assembly |
US5811437A (en) * | 1996-05-21 | 1998-09-22 | Eli Lilly And Company | Methods of increasing nitric oxide synthesis |
WO1999026657A1 (en) * | 1997-11-25 | 1999-06-03 | Musc Foundation For Research Development | Inhibitors of nitric oxide synthase |
US6933272B1 (en) * | 1998-09-22 | 2005-08-23 | Erik Helmerhorst | Use of non-peptidyl compounds for the treatment of insulin related ailments |
UA76639C2 (uk) * | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Гомеопатичний лікарський засіб та спосіб лікування еректильних дисфункцій |
UA76638C2 (en) | 2002-08-02 | 2006-08-15 | Oleh Illich Epshtein | Homeopathic medication based on anti-interferon antibodies and method for treating a pathological syndrome associated with interferon |
UA76641C2 (uk) | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Гомеопатичний лікарський засіб та спосіб лікування захворювань передміхурової залози |
MXPA05001928A (es) * | 2002-08-22 | 2005-08-29 | Nutrition 21 Inc | Complejo de inositol de silicato de arginina y su empleo. |
CA2518965C (en) | 2003-03-14 | 2018-10-30 | Nutrition Research Inc. | Homeopathic formulations useful for treating pain and/or inflammmation |
CA2554045A1 (en) * | 2004-01-20 | 2005-07-28 | Astellas Pharma Inc. | Method for treating erectile dysfunction |
RU2438707C2 (ru) * | 2006-06-06 | 2012-01-10 | Олег Ильич Эпштейн | Лекарственное средство для перорального лечения сахарного диабета и других заболеваний, сопровождающихся нарушением толерантности к глюкозе, и способ получения твердой лекарственной формы для пероральной терапии сахарного диабета и других заболеваний, сопровождающихся нарушением толерантности к глюкозе |
GB0812019D0 (en) * | 2008-07-02 | 2008-08-06 | Asterion Ltd | Insulin |
EP2593477A2 (en) * | 2010-07-15 | 2013-05-22 | Oleg Iliich Epshtein | Pharmaceutical compositions and methods of treatment |
US9308275B2 (en) * | 2010-07-15 | 2016-04-12 | Oleg Iliich Epshtein | Method of increasing the effect of an activated-potentiated form of an antibody |
JP2013532182A (ja) * | 2010-07-15 | 2013-08-15 | イリイチ・エプシテイン オレグ | 組み合わせ医薬組成物及び神経変性疾患に関連する疾患又は状態を治療する方法 |
KR20130102542A (ko) * | 2010-07-21 | 2013-09-17 | 올레그 일리치 엡쉬테인 | 현기증, 동요병 및 증식형-혈관 이긴장증 치료용 제약학적 복합 조성물 및 치료 방법들 |
ES2425315R1 (es) * | 2010-07-21 | 2014-09-08 | Oleg Iliich Epshtein | Composición farmacéutica y su uso para preparar un medicamento destinado al tratamiento sintomático de una enfermedad o afección respiratoria |
-
2011
- 2011-07-15 MY MYPI2013000225A patent/MY160979A/en unknown
- 2011-07-15 EE EEP201300007A patent/EE05761B1/et not_active IP Right Cessation
- 2011-07-15 CZ CZ20130124A patent/CZ2013124A3/cs unknown
- 2011-07-15 DE DE112011102396T patent/DE112011102396T5/de not_active Withdrawn
- 2011-07-15 NZ NZ606964A patent/NZ606964A/en not_active IP Right Cessation
- 2011-07-15 KR KR1020187032943A patent/KR20180127515A/ko not_active Application Discontinuation
- 2011-07-15 GB GB1302924.4A patent/GB2496799B/en not_active Expired - Fee Related
- 2011-07-15 KR KR1020137004330A patent/KR20130103486A/ko active Application Filing
- 2011-07-15 IT IT000627A patent/ITTO20110627A1/it unknown
- 2011-07-15 MX MX2013000804A patent/MX2013000804A/es active IP Right Grant
- 2011-07-15 PE PE2013000114A patent/PE20130815A1/es not_active Application Discontinuation
- 2011-07-15 EA EA201300124A patent/EA029847B1/ru not_active IP Right Cessation
- 2011-07-15 AU AU2011281240A patent/AU2011281240B2/en not_active Ceased
- 2011-07-15 SE SE1350212A patent/SE1350212A1/sv unknown
- 2011-07-15 SG SG2013004817A patent/SG187578A1/en unknown
- 2011-07-15 BR BR112013001299A patent/BR112013001299A2/pt not_active Application Discontinuation
- 2011-07-15 ES ES201390009A patent/ES2445846R1/es active Pending
- 2011-07-15 US US13/135,891 patent/US8617555B2/en active Active
- 2011-07-15 EP EP11773314.7A patent/EP2595658A2/en not_active Ceased
- 2011-07-15 WO PCT/IB2011/002177 patent/WO2012010966A2/en active Application Filing
- 2011-07-15 EP EP19213849.3A patent/EP3693018A1/en not_active Withdrawn
- 2011-07-15 CN CN2011800454899A patent/CN103118707A/zh active Pending
- 2011-07-15 CA CA2805961A patent/CA2805961A1/en not_active Abandoned
- 2011-07-15 FR FR1156480A patent/FR2962913A1/fr not_active Withdrawn
- 2011-07-15 JP JP2013520235A patent/JP2013533268A/ja active Pending
- 2011-07-15 GB GB1707872.6A patent/GB2552405B/en not_active Expired - Fee Related
- 2011-07-21 AR ARP110102642A patent/AR082312A1/es not_active Application Discontinuation
-
2013
- 2013-01-21 CL CL2013000200A patent/CL2013000200A1/es unknown
- 2013-02-18 NO NO20130265A patent/NO20130265A1/no not_active Application Discontinuation
- 2013-02-19 LT LT2013018A patent/LT5980B/lt not_active IP Right Cessation
- 2013-02-19 DK DKPA201370089A patent/DK201370089A/da not_active Application Discontinuation
- 2013-02-21 FI FI20135152A patent/FI20135152L/fi not_active Application Discontinuation
-
2016
- 2016-07-01 JP JP2016131729A patent/JP2016222684A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998002555A1 (en) * | 1996-07-12 | 1998-01-22 | Salerno John C | Applications for regulatory region of nos isoforms |
US20100166762A1 (en) * | 2000-06-20 | 2010-07-01 | Oleg Iliich Epshtein | Method of treating a pathological syndrome |
EP2036574A1 (en) * | 2006-06-06 | 2009-03-18 | Oleg Iliich Epshtein | Medicinal agent for treating fatness, diabetes, and diseases associated with impaired glucose tolerance |
Non-Patent Citations (3)
Title |
---|
Jonas W. B. et al. A critical overview of homeopathy. Ann. Intern. Med. 2003, Vol. 138, páginas 393-399 (todo el documento) * |
Shang A. et al. Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathy. The Lancet. 27.08.2005, Vol. 366, páginas 726-732 (todo el documento) * |
Vickers A. J. et al. Clinical Trials of Homeopathy and Placebo: Analysis of a Scientific Debate. The Journal of Alternative and Complementary Medicine. 2000, Vol. 6, Nº 1, páginas 49-56 (todo el documento) * |
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