CN107106655A - 使用白细胞介素‑10治疗疾病和病症的方法 - Google Patents
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| PT3139965T (pt) | 2014-05-07 | 2021-12-27 | Applied Molecular Transp Llc | Moléculas de fusão derivadas de toxinas cholix para administração oral de carga biologicamente ativa |
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| JP7121496B2 (ja) | 2015-05-28 | 2022-08-18 | アルモ・バイオサイエンシーズ・インコーポレイテッド | 癌治療で使用するためのペグ化インターロイキン-10 |
| JP7053453B2 (ja) | 2015-08-25 | 2022-04-12 | アルモ・バイオサイエンシーズ・インコーポレイテッド | 疾患及び障害を治療するためのインターロイキン10の使用方法 |
| EP3402512A4 (en) | 2016-01-11 | 2019-09-25 | Armo Biosciences, Inc. | INTERLEUKIN-10 IN THE PREPARATION OF ANTIGEN-SPECIFIC CD8 + T CELLS AND METHOD FOR THE USE THEREOF |
| DK3650037T3 (da) | 2018-11-07 | 2022-05-02 | Applied Molecular Transport Inc | Indgivelseskonstrukter til transcytose og tilhørende fremgangsmåder |
| EP3826682A4 (en) | 2018-11-07 | 2021-11-17 | Applied Molecular Transport Inc. | CHOLIX-DERIVED MEDIA FOR ORAL HETEROLOGICAL LOADING ADMINISTRATION |
| JP2022519586A (ja) * | 2019-02-04 | 2022-03-24 | ゼネティック バイオサイエンシーズ インコーポレイテッド | 糖ポリシアル酸化治療用タンパク質を使用する方法 |
| US12465640B2 (en) | 2019-02-25 | 2025-11-11 | The University Of Chicago | Methods and compositions for treating inflammatory and autoimmune conditions with ECM-affinity peptides linked to anti-inflammatory agents |
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| CN115667290A (zh) | 2020-05-12 | 2023-01-31 | 再生元制药公司 | 新型il10激动剂及其使用方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101631560A (zh) * | 2006-09-28 | 2010-01-20 | 先灵公司 | 聚乙二醇化的白细胞介素-10治疗癌的用途 |
| WO2010022227A1 (en) * | 2008-08-20 | 2010-02-25 | Schering Corporation | Methods for monitoring il-10 therapy |
| CN102105787A (zh) * | 2008-05-29 | 2011-06-22 | 百时美施贵宝公司 | 用于预测患者对共刺激通道调节的应答的方法 |
Family Cites Families (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1202840A (en) | 1985-06-10 | 1986-04-08 | Jonathan R. Kleinsasser | Combination wet and dry feeder for animals |
| JPS63152393A (ja) | 1986-07-03 | 1988-06-24 | Takeda Chem Ind Ltd | グリコシル誘導体 |
| US5714585A (en) | 1987-10-26 | 1998-02-03 | Sterling Winthrop, Inc. | Antibodies that are immunoreactive with interleukin-7 |
| US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
| US5032396A (en) | 1989-02-17 | 1991-07-16 | Immunex Corporation | IL-7 to stimulate platelet production |
| US5231012A (en) | 1989-06-28 | 1993-07-27 | Schering Corporation | Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10) |
| US6217857B1 (en) | 1989-06-28 | 2001-04-17 | Schering Corporation | Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof |
| US5229115A (en) | 1990-07-26 | 1993-07-20 | Immunex Corporation | Adoptive immunotherapy with interleukin-7 |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| US5156301A (en) | 1990-12-17 | 1992-10-20 | Imi Cornelius Inc. | Constant ratio post-mix beverage dispensing valve |
| ATE116550T1 (de) | 1991-01-16 | 1995-01-15 | Schering Corp | Behandlung von neoplastischen krankenheiten mit interleukin-10. |
| EP0567586B1 (en) | 1991-01-16 | 1995-07-12 | Schering Corporation | Use of interleukin-10 in adoptive immunotherapy of cancer |
| US5624823A (en) | 1991-11-22 | 1997-04-29 | The General Hospital Corporation | DNA encoding procine interleukin-10 |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| AU6000894A (en) | 1993-02-01 | 1994-08-29 | Michel Goldman | Use of a pharmaceutical composition comprising an effective amount of interleukin-10, an analog and/or an agonist of interleukin-10 |
| US5328989A (en) | 1993-03-05 | 1994-07-12 | Schering-Plough | Purification of human interleukin-10 from a cell culture medium |
| US5552303A (en) | 1993-03-08 | 1996-09-03 | Immunex Corporation | DNA encoding epithelium-derived T-cell factor |
| WO1994022473A1 (en) | 1993-04-01 | 1994-10-13 | University Of Washington | Use of interleukin 7 to improve vaccine potency |
| US5665345A (en) | 1993-05-24 | 1997-09-09 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of inhibiting viral replication using IL-10 |
| NZ269663A (en) | 1993-07-26 | 1997-09-22 | Schering Corp | Agonists and antagonists of il-10 |
| GB9317618D0 (en) | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5951974A (en) | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| PL175343B1 (pl) | 1994-01-20 | 1998-12-31 | Schering Corp | Sposób pozaustrojowego wytwarzania aktywowanych jednojądrzastych komórek krwi obwodowej, kompozycja farmaceutyczna do pozaustrojowego wytwarzania aktywowanych jednojądrzastych komórek krwi obwodowej i kompozycja farmaceutyczna do leczenia nowotworów |
| US5696234A (en) | 1994-08-01 | 1997-12-09 | Schering Corporation | Muteins of mammalian cytokine interleukin-13 |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US6410008B1 (en) | 1994-12-12 | 2002-06-25 | Beth Israel Hospital Association | Chimeric IL-10 proteins and uses thereof |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5866134A (en) | 1995-03-24 | 1999-02-02 | Schering Corporation | Method for enhancing the antibody response to specific antigens with Interleukin-10 |
| US5770190A (en) | 1995-07-14 | 1998-06-23 | Schering Corporation | Method of treatment of acute leukemia with inteleukin-10 |
| GB2304047A (en) | 1995-08-09 | 1997-03-12 | Univ Manchester | Pharmaceutical compositions containing cytokines |
| US5744451A (en) | 1995-09-12 | 1998-04-28 | Warner-Lambert Company | N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| US5759859A (en) | 1996-07-15 | 1998-06-02 | United States Of America As Represented By The Secretary Of The Army | Sensor and method for detecting trace underground energetic materials |
| US5945097A (en) | 1996-09-06 | 1999-08-31 | Schering Corporation | Method for lowering cholesterol levels with interleukin-10 |
| US5989867A (en) | 1996-09-23 | 1999-11-23 | Knappe; Andrea | DNA encoding IL-10-like homologue; related reagents |
| US6660258B1 (en) | 1997-05-09 | 2003-12-09 | Pharma Pacific Pty Ltd | Oromucosal cytokine compositions and uses thereof |
| IL133974A0 (en) | 1997-07-14 | 2001-04-30 | Bolder Biotechnology Inc | Derivatives of growth hormone and related proteins |
| US5985263A (en) | 1997-12-19 | 1999-11-16 | Enzon, Inc. | Substantially pure histidine-linked protein polymer conjugates |
| US6362276B1 (en) | 1998-01-07 | 2002-03-26 | Debio Recherche Pharmaceutique S.A. | Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom |
| US6428985B1 (en) | 1998-12-02 | 2002-08-06 | The Regents Of The University Of Michigan | Immunosuppressive structural definition of IL-10 |
| AU2158000A (en) | 1998-12-22 | 2000-07-12 | Schering Corporation | Treatment of hepatitis c virus infections with interleukin-10 |
| US7666400B2 (en) | 2005-04-06 | 2010-02-23 | Ibc Pharmaceuticals, Inc. | PEGylation by the dock and lock (DNL) technique |
| AU5827000A (en) | 1999-07-16 | 2001-02-05 | Maria Teresa Bejarano | Viral il-10 uses |
| US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| US20030186386A1 (en) | 2000-02-11 | 2003-10-02 | Hansen Christian Karsten | Interleukin 10 |
| AU2001231532A1 (en) | 2000-02-11 | 2001-08-20 | Maxygen Aps | Improved interleukin 10 |
| ES2367891T3 (es) | 2000-09-29 | 2011-11-10 | Schering Corporation | Interleucina-10 pegilada. |
| JP2002142770A (ja) | 2000-11-08 | 2002-05-21 | Dnavec Research Inc | 循環系への遺伝子送達用パラミクソウイルスベクター |
| US6838452B2 (en) | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
| EP1234583A1 (en) | 2001-02-23 | 2002-08-28 | F. Hoffmann-La Roche Ag | PEG-conjugates of HGF-NK4 |
| AU2002307497A1 (en) | 2001-04-23 | 2002-11-05 | The Regents Of The University Of California | Methods of using interleukin-7 to modulate physiological processes in mammalian pulmonary fibroblasts |
| GB0212648D0 (en) | 2002-05-31 | 2002-07-10 | Immunoclin Lab Ltd | Treatment with cytokines |
| EP1391513A1 (en) | 2002-08-08 | 2004-02-25 | Cytheris | IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof |
| US7611700B2 (en) | 2002-09-09 | 2009-11-03 | Hanall Pharmaceuticals, Co., Ltd. | Protease resistant modified interferon alpha polypeptides |
| US20040142893A1 (en) * | 2002-10-21 | 2004-07-22 | Uichi Ikeda | Methods for treating and preventing vascular disease |
| AU2003280315A1 (en) | 2002-11-14 | 2004-06-03 | Maxygen, Inc. | Conjugates of interleukin-10 and polymers |
| ES2312820T3 (es) | 2002-11-29 | 2009-03-01 | Maria Grazia Roncarolo | Paramicina e il-10 para el tratamiento de enfermedades autoinmunes. |
| AU2003303222A1 (en) | 2002-12-19 | 2004-07-14 | Universiteit Gent | Mutant proteins showing increased secretion |
| WO2004056875A1 (en) | 2002-12-23 | 2004-07-08 | Wyeth | Antibodies against pd-1 and uses therefor |
| US20040136952A1 (en) | 2002-12-26 | 2004-07-15 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
| EP2949658B1 (en) | 2003-03-03 | 2018-08-08 | Dyax Corp. | Peptides that specifically bind HGF receptor (cMet) and uses thereof |
| EP1613274B1 (en) | 2003-04-15 | 2010-03-03 | GlaxoSmithKline LLC | Human il-18 substitution mutants and their conjugates |
| US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
| WO2005033307A1 (ja) | 2003-09-30 | 2005-04-14 | Kyowa Hakko Kogyo Co., Ltd. | 新規のリフォールディング方法およびその方法によって得られたタンパク質 |
| ATE457353T1 (de) | 2003-11-28 | 2010-02-15 | Univ Sydney | Virales latentphasen-interleukin-10-(vii-10) und verwendungen davon |
| DK1699822T3 (da) | 2003-12-30 | 2008-08-04 | Merck Patent Gmbh | IL-7-fusionsproteiner med antistofdele, fremstilling deraf og anvendelse deraf |
| US20060078942A1 (en) * | 2004-03-10 | 2006-04-13 | Pepgen Corporation | Method of treatment using interferon-tau |
| SG151261A1 (en) | 2004-03-11 | 2009-04-30 | Fresenius Kabi De Gmbh | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination |
| US20060046961A1 (en) | 2004-09-02 | 2006-03-02 | Mckay William F | Controlled and directed local delivery of anti-inflammatory compositions |
| CN100334112C (zh) | 2004-10-15 | 2007-08-29 | 上海海欣生物技术有限公司 | 人白细胞介素15与Fc融合蛋白 |
| DE602005020837D1 (de) | 2004-12-09 | 2010-06-02 | Merck Patent Gmbh | Il-7-varianten mit reduzierter immunogenität |
| GB0500643D0 (en) | 2005-01-13 | 2005-02-23 | Renovo Ltd | Medicaments |
| WO2006094530A1 (en) | 2005-03-11 | 2006-09-14 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
| AR052741A1 (es) | 2005-04-08 | 2007-03-28 | Noxxon Pharma Ag | Acidos nucleicos de union a ghrelin |
| EP1901769A2 (en) | 2005-05-02 | 2008-03-26 | Avigen, Inc. | Use of cytokine-derived peptides in treatment of pain and neurodegenerative disease |
| US7749490B2 (en) | 2005-05-31 | 2010-07-06 | The Regents Of The University Of Colorado | Mutant IL-10 |
| CA2655511C (en) | 2005-07-01 | 2017-03-21 | John Schrader | Methods of isolating cells and generating monoclonal antibodies |
| EP1746161A1 (en) | 2005-07-20 | 2007-01-24 | Cytheris | Glycosylated IL-7, preparation and uses |
| WO2007041713A1 (en) | 2005-10-04 | 2007-04-12 | Zymogenetics, Inc. | Production and purification of il-29 |
| US7939056B2 (en) | 2005-11-14 | 2011-05-10 | The Brigham And Women's Hospital, Inc. | Interleukin-10 compositions for the treatment of adenocarcinomas |
| WO2007087576A2 (en) | 2006-01-24 | 2007-08-02 | The Uab Research Foundation | Compositions and methods for the identification and treatment of immune-mediated inflammatory diseases |
| JP2010506166A (ja) | 2006-10-05 | 2010-02-25 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | デング熱の診断及び治療 |
| US8247370B2 (en) | 2006-12-04 | 2012-08-21 | Promedior, Inc. | Conjoint therapy for treating fibrotic diseases |
| AU2008206077A1 (en) | 2007-01-19 | 2008-07-24 | Kai Pharmaceuticals, Inc. | Modifications of peptide compositions to increase stability and delivery efficiency |
| US8937153B2 (en) | 2007-07-31 | 2015-01-20 | Affibody Ab | Compositions, methods and uses |
| WO2009036568A1 (en) | 2007-09-19 | 2009-03-26 | University Health Network | Methods and compositions for treating tumors and viral infections |
| CA2702494A1 (en) | 2007-10-19 | 2009-04-23 | The Regents Of The University Of California | Compositions and methods for ameliorating cns inflammation, psychosis, delirium, ptsd or ptss |
| GB0724231D0 (en) | 2007-12-12 | 2008-01-30 | Renono Ltd | Methods for inhibiting scarring |
| ES2655364T3 (es) | 2008-12-17 | 2018-02-19 | Merck Sharp & Dohme Corp. | Producción de IL-10 mono- y dipegilada y sus usos |
| WO2011045704A1 (en) | 2009-10-12 | 2011-04-21 | Pfizer Inc. | Cancer treatment |
| RU2607374C2 (ru) | 2009-10-30 | 2017-01-10 | Новозаймс Байофарма Дк А/С | Варианты альбумина |
| US9170262B2 (en) | 2010-06-16 | 2015-10-27 | Abbvie, Inc. | Comparison of protein samples |
| WO2012004384A2 (en) | 2010-07-09 | 2012-01-12 | Affibody Ab | Polypeptides |
| US8759617B2 (en) | 2010-09-21 | 2014-06-24 | National Institute Of Agrobiological Sciences | Method for extraction and purification of recombinant proteins from transgenic plants |
| PT2621519T (pt) | 2010-09-28 | 2017-10-04 | Aegerion Pharmaceuticals Inc | Polipéptido de fusão de leptina-abd com duração de ação melhorada |
| ES2563091T3 (es) | 2010-09-28 | 2016-03-10 | Amylin Pharmaceuticals, Llc | Polipéptidos modificados genéticamente que tienen duración de acción potenciada |
| HUE044038T2 (hu) * | 2010-11-05 | 2019-09-30 | Novartis Ag | Spondilitisz ankilopoetika kezelési eljárásai anti-IL-17 alkalmazásával |
| CN110200997A (zh) | 2011-03-23 | 2019-09-06 | 弗雷德哈钦森癌症研究中心 | 用于细胞免疫治疗的方法和组合物 |
| CN102145178B (zh) | 2011-04-15 | 2012-09-26 | 北京凯因科技股份有限公司 | Peg化白介素15 |
| EP2537933A1 (en) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
| US10391126B2 (en) | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
| KR20140125803A (ko) | 2012-01-26 | 2014-10-29 | 암젠 인크 | 성장 분화 인자 15(gdf-15) 폴리펩타이드들 |
| CN104245722A (zh) | 2012-02-29 | 2014-12-24 | Ambrx公司 | 白细胞介素-10多肽结合物和其用途 |
| US20150118244A1 (en) | 2012-05-10 | 2015-04-30 | Bristol-Myers Squibb Company | Anti-tumor antibodies as predictive or prognostic biomarkers of efficacy and survival in ipilimumab-treated patients |
| RU2679889C2 (ru) | 2013-04-18 | 2019-02-14 | Армо Байосайенсиз, Инк. | Способы применения интерлейкина-10 для лечения заболеваний и расстройств |
| US20160068583A1 (en) | 2013-04-24 | 2016-03-10 | Armo Biosciences, Inc. | Interleukin-10 Compositions and Uses Thereof |
| US9823255B2 (en) | 2013-06-17 | 2017-11-21 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
| WO2015031316A1 (en) | 2013-08-30 | 2015-03-05 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| CN105848674A (zh) | 2013-11-11 | 2016-08-10 | 阿尔莫生物科技股份有限公司 | 将白细胞介素-10用于治疗疾病和病症的方法 |
| US20160375101A1 (en) | 2014-01-15 | 2016-12-29 | Armo Biosciences, Inc. | Methods of Using Interleukin-10 for Treating Diseases and Disorders |
| ES2963718T3 (es) | 2014-01-21 | 2024-04-01 | Novartis Ag | Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras |
| MA39711A (fr) | 2014-04-03 | 2015-10-08 | Nektar Therapeutics | Conjugués d'une fraction d'il-15 et d'un polymère |
| CN106573072A (zh) | 2014-06-02 | 2017-04-19 | 阿尔莫生物科技股份有限公司 | 降低血清胆固醇的方法 |
| EP3237441A4 (en) | 2014-12-23 | 2018-06-06 | Armo Biosciences, Inc. | Methods of improving yield in recombinant protein production |
| CN107405384A (zh) | 2015-03-11 | 2017-11-28 | 尼克塔治疗公司 | Il‑7部分与聚合物的缀合物 |
| JP7121496B2 (ja) | 2015-05-28 | 2022-08-18 | アルモ・バイオサイエンシーズ・インコーポレイテッド | 癌治療で使用するためのペグ化インターロイキン-10 |
-
2015
- 2015-10-20 MX MX2017004983A patent/MX2017004983A/es unknown
- 2015-10-20 WO PCT/US2015/056383 patent/WO2016064817A1/en not_active Ceased
- 2015-10-20 CA CA2963995A patent/CA2963995A1/en not_active Abandoned
- 2015-10-20 KR KR1020177011082A patent/KR20170084033A/ko not_active Withdrawn
- 2015-10-20 ES ES15852286T patent/ES2941234T3/es active Active
- 2015-10-20 EP EP15852286.2A patent/EP3209320B1/en active Active
- 2015-10-20 US US15/513,825 patent/US10143726B2/en active Active
- 2015-10-20 JP JP2017521564A patent/JP6675394B2/ja active Active
- 2015-10-20 CN CN201580069348.9A patent/CN107106655A/zh active Pending
- 2015-10-20 AU AU2015336101A patent/AU2015336101A1/en not_active Abandoned
-
2017
- 2017-03-29 ZA ZA2017/02214A patent/ZA201702214B/en unknown
-
2018
- 2018-10-23 US US16/168,345 patent/US10653751B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101631560A (zh) * | 2006-09-28 | 2010-01-20 | 先灵公司 | 聚乙二醇化的白细胞介素-10治疗癌的用途 |
| CN102105787A (zh) * | 2008-05-29 | 2011-06-22 | 百时美施贵宝公司 | 用于预测患者对共刺激通道调节的应答的方法 |
| WO2010022227A1 (en) * | 2008-08-20 | 2010-02-25 | Schering Corporation | Methods for monitoring il-10 therapy |
Non-Patent Citations (1)
| Title |
|---|
| 言慧等: "白介素10的临床应用研究", 《生命的化学》 * |
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