MX354016B - Sistemas y metodos de suministro de agentes bioactivos mediante el uso de secuencias transportadoras derivadas de toxinas. - Google Patents

Sistemas y metodos de suministro de agentes bioactivos mediante el uso de secuencias transportadoras derivadas de toxinas.

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Publication number
MX354016B
MX354016B MX2013002939A MX2013002939A MX354016B MX 354016 B MX354016 B MX 354016B MX 2013002939 A MX2013002939 A MX 2013002939A MX 2013002939 A MX2013002939 A MX 2013002939A MX 354016 B MX354016 B MX 354016B
Authority
MX
Mexico
Prior art keywords
delivery
systems
cholix
methods
bioactive agents
Prior art date
Application number
MX2013002939A
Other languages
English (en)
Other versions
MX2013002939A (es
Inventor
Mahmood Tahir
J Mrsny Randall
Original Assignee
J Mrsny Randall
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Mrsny Randall filed Critical J Mrsny Randall
Publication of MX2013002939A publication Critical patent/MX2013002939A/es
Publication of MX354016B publication Critical patent/MX354016B/es

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Abstract

La presente invención se refiere a una forma mutante no tóxica del gen Cholix de Vibrio cholera (ntCholix), una variante de Cholix truncada en el aminoácido A386 (Cholix386) y el uso de otras varias secuencias de polipéptidos derivadas de Cholix para mejorar el suministro intestinal de productos terapéuticos farmacéuticos biológicamente activos. Los sistemas y métodos descritos en la presente proporcionan lo siguiente: la capacidad de suministrar dosis de macromoléculas sin inyecciones; la capacidad de suministrar carga, tal como (a modo no taxativo) ARNpi o moléculas antisentido, en compartimientos intracelulares donde su actividad es requerida; y el suministro de nanopartículas y portadores a base de dendrímeros a través de membranas biológicas que de otro modo se hubiera impedido debido a las propiedades de barrera de la mayoría de dichas membranas.
MX2013002939A 2010-09-15 2011-09-15 Sistemas y metodos de suministro de agentes bioactivos mediante el uso de secuencias transportadoras derivadas de toxinas. MX354016B (es)

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MX2013002939A (es) 2013-10-03
CA2848656C (en) 2017-10-10
BR112013006088A2 (pt) 2020-06-16
WO2012036746A1 (en) 2012-03-22
US9090691B2 (en) 2015-07-28
US10617767B2 (en) 2020-04-14
JP2017093449A (ja) 2017-06-01
JP6133208B2 (ja) 2017-05-24
CN105541978B (zh) 2019-12-13
US20190388550A1 (en) 2019-12-26
EP2616045B1 (en) 2017-10-25
ZA201302658B (en) 2014-06-25
KR101881176B1 (ko) 2018-07-23
AU2011302645B2 (en) 2015-02-26
KR20140014068A (ko) 2014-02-05
JP2013541523A (ja) 2013-11-14
US20150265719A1 (en) 2015-09-24
CN103249401B (zh) 2016-01-20
NO2616045T3 (es) 2018-03-24
RU2593715C2 (ru) 2016-08-10
BR112013006088B1 (pt) 2022-06-14
IL225171B (en) 2018-11-29
RU2013116447A (ru) 2014-10-20
JP6433970B2 (ja) 2018-12-05
AU2011302645A1 (en) 2013-05-02
US20180353610A1 (en) 2018-12-13
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US20130172229A1 (en) 2013-07-04
CN103249401A (zh) 2013-08-14
US20150265718A1 (en) 2015-09-24
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US20190388520A1 (en) 2019-12-26
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