BRPI0920749A8 - Proteínas de ligação de antagonista multialvo cd86 - Google Patents

Proteínas de ligação de antagonista multialvo cd86

Info

Publication number
BRPI0920749A8
BRPI0920749A8 BRPI0920749A BRPI0920749A BRPI0920749A8 BR PI0920749 A8 BRPI0920749 A8 BR PI0920749A8 BR PI0920749 A BRPI0920749 A BR PI0920749A BR PI0920749 A BRPI0920749 A BR PI0920749A BR PI0920749 A8 BRPI0920749 A8 BR PI0920749A8
Authority
BR
Brazil
Prior art keywords
agonist
antagonist
multialvo
binding proteins
antagonist binding
Prior art date
Application number
BRPI0920749A
Other languages
English (en)
Inventor
Tan Philip
w blankenship John
Kumar Natarajan Sateesh
Armstrong Thompson Peter
Robert Baum Peter
Original Assignee
Emergent Product Dev Seattle
Aptevo Res & Development Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emergent Product Dev Seattle, Aptevo Res & Development Llc filed Critical Emergent Product Dev Seattle
Publication of BRPI0920749A2 publication Critical patent/BRPI0920749A2/pt
Publication of BRPI0920749A8 publication Critical patent/BRPI0920749A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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Abstract

PROTEÍNAS DE LIGAÇÃO DE ANTAGONISTAS MULTIALVO CD86 Esta descrição fornece uma proteína de fusão multiespecífica composta de um domínio de ligação do antagonista CD86 e outro domínio de ligação que é um agonista IL-10, um agonista HLA-G, um agonista HGF, um agonista IL-35, um agonista PD-1, um agonista BTLA, um antagonista LIGHT, um antagonista GITRL ou um antagonista CD40. a proteína de fusão multiespecífica pode igualmente incluir um domínio de intervenção que separa os outros domínios. Esta descrição também fornece os polinucleotídeos que codificam as proteí-nas de fusão multiespecíficas, composições das proteínas de fusão, e méto-dos de uso das proteínas de fusão multiespecíficas e as composições.
BRPI0920749A 2008-10-02 2009-10-02 Proteínas de ligação de antagonista multialvo cd86 BRPI0920749A8 (pt)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US10229708P 2008-10-02 2008-10-02
US10232708P 2008-10-02 2008-10-02
US10230708P 2008-10-02 2008-10-02
US10233608P 2008-10-02 2008-10-02
US10233408P 2008-10-02 2008-10-02
US10228808P 2008-10-02 2008-10-02
US10231508P 2008-10-02 2008-10-02
US10231908P 2008-10-02 2008-10-02
US10233108P 2008-10-02 2008-10-02
PCT/US2009/059446 WO2010040105A2 (en) 2008-10-02 2009-10-02 Cd86 antagonist multi-target binding proteins

Publications (2)

Publication Number Publication Date
BRPI0920749A2 BRPI0920749A2 (pt) 2016-05-03
BRPI0920749A8 true BRPI0920749A8 (pt) 2017-12-12

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Application Number Title Priority Date Filing Date
BRPI0920749A BRPI0920749A8 (pt) 2008-10-02 2009-10-02 Proteínas de ligação de antagonista multialvo cd86

Country Status (23)

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US (2) US9493564B2 (pt)
EP (2) EP2344540B1 (pt)
JP (4) JP5840494B2 (pt)
KR (5) KR20170091801A (pt)
CN (2) CN107056951A (pt)
AU (4) AU2009298131B2 (pt)
BR (1) BRPI0920749A8 (pt)
CA (2) CA3038442A1 (pt)
CY (1) CY1119874T1 (pt)
DK (1) DK2344540T3 (pt)
EA (1) EA024877B1 (pt)
ES (1) ES2657220T3 (pt)
HK (1) HK1251000A1 (pt)
HR (1) HRP20180045T1 (pt)
LT (1) LT2344540T (pt)
MX (1) MX338825B (pt)
NO (1) NO2344540T3 (pt)
NZ (1) NZ592420A (pt)
PL (1) PL2344540T3 (pt)
PT (1) PT2344540T (pt)
SI (1) SI2344540T1 (pt)
WO (1) WO2010040105A2 (pt)
ZA (1) ZA201102637B (pt)

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US7030219B2 (en) 2000-04-28 2006-04-18 Johns Hopkins University B7-DC, Dendritic cell co-stimulatory molecules
KR20110043643A (ko) * 2008-07-02 2011-04-27 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 인터루킨 6 면역치료제
NZ590668A (en) * 2008-07-02 2012-12-21 Emergent Product Dev Seattle TNF-alpha ANTAGONIST MULTI-TARGET BINDING PROTEINS
CA3038442A1 (en) * 2008-10-02 2010-04-08 Aptevo Research And Development Llc Cd86 antagonist multi-target binding proteins
NZ603623A (en) * 2008-10-10 2014-05-30 Emergent Product Dev Seattle Tcr complex immunotherapeutics
JP2013512251A (ja) * 2009-11-24 2013-04-11 アンプリミューン、インコーポレーテッド Ｐｄ−ｌ１／ｐｄ−ｌ２の同時阻害
US11246915B2 (en) 2010-09-15 2022-02-15 Applied Molecular Transport Inc. Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
MX354016B (es) 2010-09-15 2018-02-07 J Mrsny Randall Sistemas y metodos de suministro de agentes bioactivos mediante el uso de secuencias transportadoras derivadas de toxinas.
CN101962413B (zh) * 2010-09-21 2013-03-13 中国科学技术大学 具有透皮能力和白细胞介素-10活性的融合蛋白及其编码基因与应用
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