CY1119874T1 - Πρωτεϊνες συνδεσης πολλαπλου-στοχου ανταγωνιστη cd86 - Google Patents

Πρωτεϊνες συνδεσης πολλαπλου-στοχου ανταγωνιστη cd86

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Publication number
CY1119874T1
CY1119874T1 CY20181100118T CY181100118T CY1119874T1 CY 1119874 T1 CY1119874 T1 CY 1119874T1 CY 20181100118 T CY20181100118 T CY 20181100118T CY 181100118 T CY181100118 T CY 181100118T CY 1119874 T1 CY1119874 T1 CY 1119874T1
Authority
CY
Cyprus
Prior art keywords
agonist
component
antagonist
specific fusion
fusion protein
Prior art date
Application number
CY20181100118T
Other languages
English (en)
Inventor
Peter Armstrong Thompson
Peter Robert Baum
Philip Tan
John W. Blankenship
Sateesh Kumar Natarajan
Original Assignee
Aptevo Research And Development Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aptevo Research And Development Llc filed Critical Aptevo Research And Development Llc
Publication of CY1119874T1 publication Critical patent/CY1119874T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C07K14/54—Interleukins [IL]
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    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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Abstract

Η αποκάλυψη αυτή παρέχει πολυ-ειδική πρωτεΐνη σύντηξης αποτελούμενη από πεδίο σύνδεσης ανταγωνιστή CD86 και άλλο πεδίο σύνδεσης που είναι αγωνιστής IL-10, αγωνιστής HLA-G, αγωνιστής HGF, αγωνιστής IL-35, αγωνιστής PD-1, αγωνιστής BTLA, ανταγωνιστής LIGHT, ανταγωνιστής GITRL ή ανταγωνιστής CD40. Η πολυ-ειδική πρωτεΐνη σύντηξης μπορεί επίσης να περιλαμβάνει παρεμβαλλόμενο πεδίο το οποίο διαχωρίζει τα άλλα πεδία. Η αποκάλυψη αυτή επίσης παρέχει πολυνουκλεοτίδια που κωδικοποιούν τις πολυ-ειδικές πρωτεΐνες σύντηξης, συνθέσεις των πρωτεϊνών σύντηξης και μεθόδους χρήσης των πολυ-ειδικών πρωτεϊνών σύντηξης και συνθέσεων.
CY20181100118T 2008-10-02 2018-01-31 Πρωτεϊνες συνδεσης πολλαπλου-στοχου ανταγωνιστη cd86 CY1119874T1 (el)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US10233408P 2008-10-02 2008-10-02
US10232708P 2008-10-02 2008-10-02
US10228808P 2008-10-02 2008-10-02
US10230708P 2008-10-02 2008-10-02
US10231508P 2008-10-02 2008-10-02
US10231908P 2008-10-02 2008-10-02
US10229708P 2008-10-02 2008-10-02
US10233108P 2008-10-02 2008-10-02
US10233608P 2008-10-02 2008-10-02
PCT/US2009/059446 WO2010040105A2 (en) 2008-10-02 2009-10-02 Cd86 antagonist multi-target binding proteins

Publications (1)

Publication Number Publication Date
CY1119874T1 true CY1119874T1 (el) 2018-06-27

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CY20181100118T CY1119874T1 (el) 2008-10-02 2018-01-31 Πρωτεϊνες συνδεσης πολλαπλου-στοχου ανταγωνιστη cd86

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US (2) US9493564B2 (el)
EP (2) EP2344540B1 (el)
JP (4) JP5840494B2 (el)
KR (5) KR20160120812A (el)
CN (2) CN107056951A (el)
AU (4) AU2009298131B2 (el)
BR (1) BRPI0920749A8 (el)
CA (2) CA3038442A1 (el)
CY (1) CY1119874T1 (el)
DK (1) DK2344540T3 (el)
EA (1) EA024877B1 (el)
ES (1) ES2657220T3 (el)
HK (1) HK1251000A1 (el)
HR (1) HRP20180045T1 (el)
LT (1) LT2344540T (el)
MX (1) MX338825B (el)
NO (1) NO2344540T3 (el)
NZ (1) NZ592420A (el)
PL (1) PL2344540T3 (el)
PT (1) PT2344540T (el)
SI (1) SI2344540T1 (el)
WO (1) WO2010040105A2 (el)
ZA (1) ZA201102637B (el)

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