HK1251000A1 - Cd86對抗藥多靶點結合蛋白 - Google Patents
Cd86對抗藥多靶點結合蛋白Info
- Publication number
- HK1251000A1 HK1251000A1 HK18110446.9A HK18110446A HK1251000A1 HK 1251000 A1 HK1251000 A1 HK 1251000A1 HK 18110446 A HK18110446 A HK 18110446A HK 1251000 A1 HK1251000 A1 HK 1251000A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- binding proteins
- target binding
- antagonist multi
- antagonist
- target
- Prior art date
Links
- 229940121764 CD86 antagonist Drugs 0.000 title 1
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 108091008324 binding proteins Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10231908P | 2008-10-02 | 2008-10-02 | |
US10231508P | 2008-10-02 | 2008-10-02 | |
US10233108P | 2008-10-02 | 2008-10-02 | |
US10228808P | 2008-10-02 | 2008-10-02 | |
US10230708P | 2008-10-02 | 2008-10-02 | |
US10233408P | 2008-10-02 | 2008-10-02 | |
US10232708P | 2008-10-02 | 2008-10-02 | |
US10229708P | 2008-10-02 | 2008-10-02 | |
US10233608P | 2008-10-02 | 2008-10-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1251000A1 true HK1251000A1 (zh) | 2019-01-18 |
Family
ID=41557444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18110446.9A HK1251000A1 (zh) | 2008-10-02 | 2018-08-14 | Cd86對抗藥多靶點結合蛋白 |
Country Status (23)
Country | Link |
---|---|
US (2) | US9493564B2 (zh) |
EP (2) | EP2344540B1 (zh) |
JP (4) | JP5840494B2 (zh) |
KR (5) | KR20190064664A (zh) |
CN (2) | CN107056951A (zh) |
AU (4) | AU2009298131B2 (zh) |
BR (1) | BRPI0920749A8 (zh) |
CA (2) | CA2739460C (zh) |
CY (1) | CY1119874T1 (zh) |
DK (1) | DK2344540T3 (zh) |
EA (1) | EA024877B1 (zh) |
ES (1) | ES2657220T3 (zh) |
HK (1) | HK1251000A1 (zh) |
HR (1) | HRP20180045T1 (zh) |
LT (1) | LT2344540T (zh) |
MX (1) | MX338825B (zh) |
NO (1) | NO2344540T3 (zh) |
NZ (1) | NZ592420A (zh) |
PL (1) | PL2344540T3 (zh) |
PT (1) | PT2344540T (zh) |
SI (1) | SI2344540T1 (zh) |
WO (1) | WO2010040105A2 (zh) |
ZA (1) | ZA201102637B (zh) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
EA201170028A1 (ru) * | 2008-07-02 | 2011-12-30 | Эмерджент Продакт Дивелопмент Сиэтл, Ллс | СВЯЗЫВАЮЩИЕ НЕСКОЛЬКО МИШЕНЕЙ БЕЛКИ, ОБЛАДАЮЩИЕ АНТАГОНИСТИЧЕСКИМ ДЕЙСТВИЕМ TNF-α |
EA019512B1 (ru) * | 2008-07-02 | 2014-04-30 | Эмерджент Продакт Дивелопмент Сиэтл, Ллс | Il-6-опосредованная иммунотерапия |
MX338825B (es) * | 2008-10-02 | 2016-05-03 | Emergent Product Dev Seattle | Proteinas de enlace a objetivos multiples de antagonistas de cd86. |
CA2740098A1 (en) * | 2008-10-10 | 2010-04-15 | Valerie Odegard | Tcr complex immunotherapeutics |
EP2504028A4 (en) * | 2009-11-24 | 2014-04-09 | Amplimmune Inc | SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2 |
US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
CA2848656C (en) | 2010-09-15 | 2017-10-10 | Randall J. Mrsny | Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences |
CN101962413B (zh) * | 2010-09-21 | 2013-03-13 | 中国科学技术大学 | 具有透皮能力和白细胞介素-10活性的融合蛋白及其编码基因与应用 |
AU2012245260B2 (en) | 2011-04-22 | 2016-09-08 | Aptevo Research And Development Llc | Prostate-specific membrane antigen binding proteins and related compositions and methods |
WO2013070076A1 (en) * | 2011-11-08 | 2013-05-16 | Umc Utrecht Holding B.V. | Fusion protein comprising an interleukin 4 and interleukin |
BR112014025830A8 (pt) | 2012-04-20 | 2017-10-10 | Emergent Product Dev Seattle | Polipeptídeos de ligação ao cd3 |
CN104583239B (zh) | 2012-05-10 | 2018-09-18 | 生物蛋白有限公司 | 多特异单克隆抗体 |
EP2897638A1 (en) | 2012-09-24 | 2015-07-29 | Montana State University-Bozeman | Recombinant lactococcus lactis expressing escherichia coli colonization factor antigen i (cfa/i) fimbriae and their methods of use |
AR097306A1 (es) * | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
PL3081576T3 (pl) | 2013-12-12 | 2020-03-31 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Przeciwciało anty pd-1, jego fragment wiążący antygen i ich zastosowanie medyczne |
JP6202339B2 (ja) * | 2013-12-19 | 2017-09-27 | 国立研究開発法人国立精神・神経医療研究センター | GM−CSF産生T細胞制御剤、及びTh1/Th2免疫バランス調節剤 |
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- 2009-10-02 CN CN201710294122.XA patent/CN107056951A/zh active Pending
- 2009-10-02 SI SI200931787T patent/SI2344540T1/en unknown
- 2009-10-02 US US13/122,383 patent/US9493564B2/en not_active Expired - Fee Related
- 2009-10-02 KR KR1020177021715A patent/KR20170091801A/ko not_active Application Discontinuation
- 2009-10-02 EP EP17192769.2A patent/EP3281955A1/en not_active Withdrawn
- 2009-10-02 KR KR1020117010004A patent/KR101900953B1/ko active IP Right Grant
- 2009-10-02 BR BRPI0920749A patent/BRPI0920749A8/pt not_active Application Discontinuation
- 2009-10-02 KR KR1020167028124A patent/KR20160120812A/ko not_active Application Discontinuation
- 2009-10-02 LT LTEP09793296.6T patent/LT2344540T/lt unknown
- 2009-10-02 WO PCT/US2009/059446 patent/WO2010040105A2/en active Application Filing
- 2009-10-02 NZ NZ592420A patent/NZ592420A/xx not_active IP Right Cessation
- 2009-10-02 PT PT97932966T patent/PT2344540T/pt unknown
- 2009-10-02 CN CN2009801481824A patent/CN102227447A/zh active Pending
- 2009-10-02 PL PL09793296T patent/PL2344540T3/pl unknown
- 2009-10-02 ES ES09793296.6T patent/ES2657220T3/es active Active
- 2009-10-02 EA EA201170443A patent/EA024877B1/ru not_active IP Right Cessation
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2011
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2014
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- 2014-09-18 JP JP2014189637A patent/JP2014239700A/ja not_active Withdrawn
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2016
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- 2016-08-04 JP JP2016153405A patent/JP6521915B2/ja not_active Expired - Fee Related
- 2016-09-30 US US15/281,441 patent/US20170015747A1/en not_active Abandoned
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2018
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- 2018-01-31 CY CY20181100118T patent/CY1119874T1/el unknown
- 2018-05-17 AU AU2018203491A patent/AU2018203491A1/en not_active Abandoned
- 2018-08-14 HK HK18110446.9A patent/HK1251000A1/zh unknown
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