EA201100306A1 - Производные циклогексиламида и их применение в качестве антагонистов рецептора crf-1 - Google Patents
Производные циклогексиламида и их применение в качестве антагонистов рецептора crf-1Info
- Publication number
- EA201100306A1 EA201100306A1 EA201100306A EA201100306A EA201100306A1 EA 201100306 A1 EA201100306 A1 EA 201100306A1 EA 201100306 A EA201100306 A EA 201100306A EA 201100306 A EA201100306 A EA 201100306A EA 201100306 A1 EA201100306 A1 EA 201100306A1
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- EA
- Eurasian Patent Office
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- crf
- derivatives
- antagonists
- receptor
- cyclogexilamide
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract
В заявке описаны производные циклогексиламида, применимые в качестве антагонистов рецептора кортикотропин-рилизинг фактора (CRF).
Applications Claiming Priority (4)
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EP08162006 | 2008-08-07 | ||
US20513909P | 2009-01-14 | 2009-01-14 | |
EP09150543 | 2009-01-14 | ||
PCT/EP2009/060150 WO2010015655A1 (en) | 2008-08-07 | 2009-08-05 | Cyclohexyl amide derivatives and their use as crf-1 receptor antagonists |
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EA201100306A1 true EA201100306A1 (ru) | 2012-01-30 |
EA020921B1 EA020921B1 (ru) | 2015-02-27 |
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EA201100306A EA020921B1 (ru) | 2008-08-07 | 2009-08-05 | Производные циклогексиламида и их применение в качестве антагонистов рецептора crf-1 |
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CA (1) | CA2732887A1 (ru) |
CO (1) | CO6351776A2 (ru) |
EA (1) | EA020921B1 (ru) |
EC (1) | ECSP11010814A (ru) |
ES (1) | ES2582576T3 (ru) |
HN (1) | HN2011000372A (ru) |
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US8273900B2 (en) * | 2008-08-07 | 2012-09-25 | Novartis Ag | Organic compounds |
WO2011092293A2 (en) * | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
JP5748777B2 (ja) * | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Crf受容体アンタゴニストとしてのシクロヘキシルアミド誘導体 |
KR101955691B1 (ko) | 2010-03-30 | 2019-03-07 | 베르선 코포레이션 | 트롬빈 억제제로서의 다중치환된 방향족 화합물 |
WO2012088397A2 (en) | 2010-12-22 | 2012-06-28 | The Salk Institute For Biological Studies | Cyclic crf antagonist peptides |
US8546416B2 (en) | 2011-05-27 | 2013-10-01 | Novartis Ag | 3-spirocyclic piperidine derivatives as ghrelin receptor agonists |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
JP2015525202A (ja) | 2012-05-03 | 2015-09-03 | ノバルティス アーゲー | グレリン受容体アゴニストとしての2,7−ジアザ−スピロ[4,5]デカ−7−イル誘導体のl−リンゴ酸塩およびその結晶形態 |
US9814723B2 (en) | 2013-02-23 | 2017-11-14 | Lixin Zhang | Compositions and methods for prophylaxis and therapy for Meniere's disease |
CN105209440B (zh) * | 2013-03-15 | 2019-07-23 | 维颂公司 | 作为凝血酶抑制剂的卤代吡唑 |
RU2019101889A (ru) | 2013-03-15 | 2019-03-28 | Версеон Корпорейшн | Полизамещенные ароматические соединения в качестве ингибиторов сериновых протеаз |
EP3096756B1 (en) | 2014-01-21 | 2024-06-12 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia |
BR112016028255A2 (pt) | 2014-06-06 | 2017-08-22 | Flexus Biosciences Inc | agentes imunorreguladores |
CA2960790A1 (en) | 2014-09-17 | 2016-03-24 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
UY36391A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
JP2017538678A (ja) | 2014-11-05 | 2017-12-28 | フレクサス・バイオサイエンシーズ・インコーポレイテッドFlexus Biosciences, Inc. | 免疫調節剤 |
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