ECSP11010814A - Derivados de ciclohexil-amida y su uso como antagonistas de los receptores de crf-1 - Google Patents
Derivados de ciclohexil-amida y su uso como antagonistas de los receptores de crf-1Info
- Publication number
- ECSP11010814A ECSP11010814A EC2011010814A ECSP010814A ECSP11010814A EC SP11010814 A ECSP11010814 A EC SP11010814A EC 2011010814 A EC2011010814 A EC 2011010814A EC SP010814 A ECSP010814 A EC SP010814A EC SP11010814 A ECSP11010814 A EC SP11010814A
- Authority
- EC
- Ecuador
- Prior art keywords
- crf
- antagonists
- ciclohexil
- amida
- receivers
- Prior art date
Links
Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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Abstract
Se describen derivados de ciclohexil-amida útiles como antagonistas de los receptores del factor de liberación de corticotropina (CRF-1).
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US8273900B2 (en) * | 2008-08-07 | 2012-09-25 | Novartis Ag | Organic compounds |
WO2011092293A2 (en) * | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
ES2527849T3 (es) * | 2010-02-02 | 2015-01-30 | Novartis Ag | Derivados de ciclohexilamida como antagonistas del receptor de CRF |
NZ700332A (en) | 2010-03-30 | 2017-06-30 | Verseon Corp | Multisubstituted aromatic compounds as inhibitors of thrombin |
WO2012088397A2 (en) | 2010-12-22 | 2012-06-28 | The Salk Institute For Biological Studies | Cyclic crf antagonist peptides |
US8546416B2 (en) | 2011-05-27 | 2013-10-01 | Novartis Ag | 3-spirocyclic piperidine derivatives as ghrelin receptor agonists |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EA201491990A1 (ru) | 2012-05-03 | 2015-02-27 | Новартис Аг | L-малатная соль 2,7-диазаспиро[4.5]дец-7-иловых производных и их кристаллические формы в качестве агонистов грелиновых рецепторов |
US9814723B2 (en) * | 2013-02-23 | 2017-11-14 | Lixin Zhang | Compositions and methods for prophylaxis and therapy for Meniere's disease |
RU2015144193A (ru) * | 2013-03-15 | 2017-04-24 | Версеон Корпорейшн | Галогенпиразолы в качестве ингибиторов тромбина |
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CA2951259A1 (en) | 2014-06-06 | 2015-12-10 | Flexus Biosciences, Inc. | Immunoregulatory agents |
SG11201701940UA (en) | 2014-09-17 | 2017-04-27 | Verseon Corp | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
AR102537A1 (es) | 2014-11-05 | 2017-03-08 | Flexus Biosciences Inc | Agentes inmunomoduladores |
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UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
SI3261639T1 (sl) | 2015-02-27 | 2023-01-31 | Verseon International Corporation | Substituirane pirazolne spojine kot zaviralci serinskih proteaz |
US11878001B2 (en) | 2017-07-31 | 2024-01-23 | Novartis Ag | Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use |
CA3085132A1 (en) | 2017-12-13 | 2019-06-20 | Praxis Biotech LLC | Inhibitors of integrated stress response pathway |
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BR112020023115A2 (pt) | 2018-06-05 | 2021-02-02 | Praxis Biotech LLC | inibidores da via integrada de resposta a tensão |
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