EA200970894A1 - Производные хинолина в качестве лигандов рецепторов crth2 - Google Patents

Производные хинолина в качестве лигандов рецепторов crth2

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Publication number
EA200970894A1
EA200970894A1 EA200970894A EA200970894A EA200970894A1 EA 200970894 A1 EA200970894 A1 EA 200970894A1 EA 200970894 A EA200970894 A EA 200970894A EA 200970894 A EA200970894 A EA 200970894A EA 200970894 A1 EA200970894 A1 EA 200970894A1
Authority
EA
Eurasian Patent Office
Prior art keywords
quinoline derivatives
receptor ligands
crth2 receptor
crth2
derivatives
Prior art date
Application number
EA200970894A
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English (en)
Inventor
Николас Чарльз Рэй
Гарри Финч
Майкл Колин Крамп
Роза Ариэнцо
Джордж Хайнд
Питер Кракетт
Янн Гриффон
Тревор Кейт Гаррисон
Джон Гарри Монтана
Original Assignee
Арджента Орал Терапьютикс Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Арджента Орал Терапьютикс Лимитед filed Critical Арджента Орал Терапьютикс Лимитед
Publication of EA200970894A1 publication Critical patent/EA200970894A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2

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  • Health & Medical Sciences (AREA)
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  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
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Abstract

Конкретные производные хинолина являются антагонистами CRTH2 и полезны в лечении состояний, имеющих воспалительный компонент.
EA200970894A 2007-03-29 2007-03-29 Производные хинолина в качестве лигандов рецепторов crth2 EA200970894A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2007/001138 WO2008119917A1 (en) 2007-03-29 2007-03-29 Quinoline derivatives as crth2 receptor ligands

Publications (1)

Publication Number Publication Date
EA200970894A1 true EA200970894A1 (ru) 2010-04-30

Family

ID=38728830

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970894A EA200970894A1 (ru) 2007-03-29 2007-03-29 Производные хинолина в качестве лигандов рецепторов crth2

Country Status (13)

Country Link
US (1) US20100144786A1 (ru)
EP (1) EP2129661B1 (ru)
JP (1) JP2010522731A (ru)
CN (1) CN101715441A (ru)
AT (1) ATE544751T1 (ru)
AU (1) AU2007350688B2 (ru)
BR (1) BRPI0721516A2 (ru)
CA (1) CA2680636A1 (ru)
EA (1) EA200970894A1 (ru)
IL (1) IL201012A0 (ru)
MX (1) MX2009010376A (ru)
NO (1) NO20093040L (ru)
WO (1) WO2008119917A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2589709C2 (ru) * 2010-12-23 2016-07-10 Мерк Шарп Энд Домэ Корп. Хиноксалины и азахиноксалины в качестве модуляторов рецептора crth2

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602008005796D1 (de) 2007-12-14 2011-05-05 Pulmagen Therapeutics Asthma Ltd Indole und ihre therapeutische verwendung
RU2013104506A (ru) 2010-07-05 2014-08-10 Актелион Фармасьютиклз Лтд 1-фенилзамещенные производные гетероциклила и их применение в качестве модуляторов рецептора простагландина d2
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
WO2012087872A1 (en) 2010-12-23 2012-06-28 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as crth2 receptor modulators
EP2526945A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. New CRTH2 Antagonists
EP2548876A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists
EP2548863A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists.
AU2012351342A1 (en) 2011-12-16 2014-07-24 Atopix Therapeutics Limited Combination of CRTH2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
RU2014129613A (ru) 2011-12-21 2016-02-10 Актелион Фармасьютиклз Лтд Гетероциклильные производные и их применение в качестве модуляторов рецептора простагландина d2
US9169270B2 (en) 2012-07-05 2015-10-27 Actelion Pharmaceuticals Ltd. 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
GB0512944D0 (en) * 2005-06-24 2005-08-03 Argenta Discovery Ltd Indolizine compounds
BRPI0616452B8 (pt) * 2005-09-30 2021-05-25 Argenta Discovery Ltd quinolinas e seu uso terapêutico

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2589709C2 (ru) * 2010-12-23 2016-07-10 Мерк Шарп Энд Домэ Корп. Хиноксалины и азахиноксалины в качестве модуляторов рецептора crth2

Also Published As

Publication number Publication date
NO20093040L (no) 2009-09-29
WO2008119917A1 (en) 2008-10-09
AU2007350688B2 (en) 2011-02-24
JP2010522731A (ja) 2010-07-08
MX2009010376A (es) 2010-01-20
BRPI0721516A2 (pt) 2013-01-15
ATE544751T1 (de) 2012-02-15
AU2007350688A1 (en) 2008-10-09
EP2129661B1 (en) 2012-02-08
EP2129661A1 (en) 2009-12-09
US20100144786A1 (en) 2010-06-10
IL201012A0 (en) 2010-05-17
CA2680636A1 (en) 2008-10-09
CN101715441A (zh) 2010-05-26

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