CN105392435B - 具有扭绞球囊的肾神经消融导管 - Google Patents

具有扭绞球囊的肾神经消融导管 Download PDF

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CN105392435B
CN105392435B CN201480040406.0A CN201480040406A CN105392435B CN 105392435 B CN105392435 B CN 105392435B CN 201480040406 A CN201480040406 A CN 201480040406A CN 105392435 B CN105392435 B CN 105392435B
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sacculus
medical instrument
electrode assembly
flexible electrode
longitudinal axis
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CN105392435A (zh
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乔尔·N·格罗夫
帕特里克·A·哈夫科斯特
马丁·R·威拉德
曹宏
丹尼尔·J·霍恩
肯尼思·R·拉森
约翰·建华·陈
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Boston Scientific Scimed Inc
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    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
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    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
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    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
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    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1467—Probes or electrodes therefor using more than two electrodes on a single probe

Abstract

本发明公开了医疗器械及制造和使用医疗器械的方法。示范医疗器械可包括导管杆。可扩张球囊可连结至导管杆。球囊能够在折叠形态和扩张形态之间转换。支撑结构可连结至球囊。支撑结构能够使球囊朝向折叠形态转换。多个细长柔性电极组件可设置在球囊上。细长柔性电极组件可相对于球囊的纵轴线成一定角度取向。

Description

具有扭绞球囊的肾神经消融导管
相关申请的交叉引用
根据《美国法典》35卷§119，本申请要求于2013年7月22日提交的美国临时申请序号第61/857,067号的优先权，其全部内容通过引用合并在此。
技术领域
本发明涉及医疗器械及制造医疗器械的方法。更特别地，本发明涉及用于肾神经消融的医疗器械。
背景技术
已研发出各种体内医疗器械为医疗所用，例如，血管内使用。这些器械中的一些包括导丝、导管等。这些器械通过各种不同制造方法中的任一种来制造，并可根据各种方法中的任一种使用。在已知的医疗器械和方法中，各具有某些利弊。需要不断地提供替代的医疗器械及制造和使用医疗器械的替代方法。
发明内容
本发明提供了医疗器械的设计、材料、制造方法和使用替代。示范医疗器械包括用于肾神经消融的医疗器械。该医疗器械可包括导管杆。可扩张球囊可连结至导管杆。球囊能够在折叠形态和扩张形态之间转换。支撑结构可连结至球囊。支撑结构能够使球囊朝向折叠形态转换。多个细长柔性电极组件可设置在球囊上。细长柔性电极组件可相对于球囊的纵轴线成一角度取向。
用于肾神经消融的另一个示范医疗器械可包括导管杆。可扩张球囊可连结至导管杆。球囊可具有近端和远端，并具有在近端和远端之间延伸的长度。支撑结构可连结至球囊。支撑结构能够使球囊在缩回到引导导管中时以预定方式折叠。多个柔性电极组件可连结至支撑结构。
还公开了消融肾神经的示范方法。该方法可包括提供医疗器械。该医疗器械可包括导管杆。可扩张球囊可连结至导管杆。球囊能够在折叠形态和扩张形态之间转换。支撑结构可连结至球囊。支撑结构能够使球囊朝向折叠形态转换。多个细长柔性电极组件可设置在球囊上。细长柔性电极组件可相对于球囊的纵轴线成一角度取向。该方法还可包括推进医疗器械通过引导导管并进入血管至肾动脉内的位置处，扩张球囊，激活细长柔性电极组件中的至少一些，以及将球囊缩回到引导导管中。支撑结构与引导导管之间的相互作用使球囊转换至折叠形态。
一些实施方式的上述总结并不旨在描述各公开的实施方式或者本发明的每个实施。更特别地，后面的附图和具体实施方式举例说明了这些实施方式。
附图说明
连同附图，考虑以下具体实施方式可更加完整地了解本发明，其中：
图1是示范肾神经消融装置的示意图；
图2是肾神经消融装置的示范可扩张部件的立体图；
图3是图2中的可扩张部件处于展开或扁平形态下的局部顶视图；
图4是示范电极组件的一部分的顶视图；
图5是图4中的局部剖面图A-A；
图6是图4中的局部剖面图B-B；
图7是肾神经消融装置的示范可扩张部件的侧视图；
图8是示范可扩张部件的立体图；
图9是示范支撑结构的立体图；
图10是具有图9中支撑结构的图8中可扩张部件的立体图；
图11是肾神经消融装置的示范可扩张部件的侧视图；
图12A是图11中的可扩张部件处于展开或扁平形态下的局部顶视图；
图12B是替代可扩张部件处于展开或扁平形态下的局部顶视图；
图12C是替代可扩张部件处于展开或扁平形态下的局部顶视图；和
图12D是替代可扩张部件处于展开或扁平形态下的局部顶视图。
虽然本发明可修改成各种改型和替代形式，但其细节已经由附图中的示例示出，并会详细描述。然而，应当认识到，本发明并不限于描述的特定实施方式。相反，本发明覆盖了所有落入在本发明实质和范围内的改型，等同形式，以及替代形式。
具体实施方式
以下说明应当参照附图来阅读，附图不必成比例，其中在全部附图中，相同的附图标记表示相同的元件。具体实施方式和附图旨在说明，而非限制请求保护的本发明。本领域技术人员应当意识到，在不脱离本发明范围的情况下，描述和/或示出的各种元件可以以各种组合和构造布置。具体实施方式和附图说明了请求保护的本发明的示范实施方式。
对于以下定义的术语，除非是在权利要求或者是在本说明书的其它地方给出了不同的定义，否则应当使用这些定义。
无论是否明确指出，本文假定所有数值均通过术语“大约”来修饰。术语“大约”，在数值情况下，通常是指本领域技术人员会认为是与所述值相当(即，具有相同的功能或结果)的数值范围。在许多情况下，术语“大约”可包括四舍五入为最接近有效数字的数值。术语“大约”的其他使用(即，在除了数值之外的情况下)，可假定具有它们通常且常规的定义，根据说明书语境理解并与说明书的语境相一致，除非另外说明。
由端点限定的数值范围包括在该范围内的所有数值(例如，1至5包括1、1.5、2、2.75、3、3.80、4和5)。
如在本说明书和所附权利要求中所使用的，单数形式“一”和“该”包括复数指代，除非文中清楚地表明并非如此。如在本说明书和所附权利要求中所使用的，术语“或者”通常使用其包括“和/或”的含义，除非文中清楚地表明并非如此。
应当注意到，在本说明书中提及“一实施方式”，“一些实施方式”，“其他实施方式”等表明描述的该实施方式可包括特定的特征，结构，或特性，但不必每个实施方式都包括该特定的特征，结构，或特性。此外，这种短语不必指代同一实施方式。而且，当在一实施方式中描述特定的特征，结构，或特性时，本领域技术人员应当理解，不论是否明确描述，这种特征，结构，和/或特性也可用于其他实施方式中，除非清楚地表明相反。即，以下描述的各种单个的元件，即使没有以特定组合明确示出，虽然如此，可以预期，其可相互结合或设置以形成其他的附加实施方式或者补充和/或充实描述的实施方式，如本领域技术人员理解的。
某些治疗旨在暂时或永久中断或者改变选择的神经功能。一个示范治疗是肾神经消融，其有时用来治疗诸如高血压、充血性心力衰竭、糖尿病或与高血压、充血性心力衰竭、糖尿病有关的状况，或其他受高血压或盐滞留影响的状况。肾脏产生交感神经响应，其可增加水和/或钠不期望的滞留。交感神经响应的结果可能，例如，增加血压。对一些延伸到肾脏的神经(例如，邻近肾动脉设置或以其他方式沿肾动脉设置)的消融可减少或消除这种交感神经响应，这可促进相关联的不期望的症状相应减轻(例如，血压降低)。
本发明的一些实施方式涉及能量产生及控制装置，通常用于靶组织的治疗以实现治疗效果。在一些实施方式中，靶组织是包含神经或接近神经的组织，包括肾动脉和关联的肾神经。在其他实施方式中，靶组织是腔组织，其可进一步包括诸如在动脉疾病中发现的病变组织。
在本发明一些实施方式中，按目标剂量传送能量的能力可用于神经组织以实现有益的生物响应。例如，已知慢性疼痛、泌尿障碍、高血压、以及许多其他的持续性状况通过神经组织手术而受到影响。例如，已知，可能不对药物响应的慢性高血压可通过使接近肾动脉的过多神经活动失效而得到改善或者根除。还知道，神经组织生来不具有再生特性。因此，通过破坏神经组织的传导路径能够有益地影响过多的神经活动。破坏神经传导路径时，避免对周围神经或器官组织造成损伤是特别有利的。指引并控制能量剂量的能力非常适合于神经组织的治疗。无论是以加热能量剂量或是消融能量剂量，如本文中描述并披露的能量传送的精确控制可指向神经组织。此外，能量的定向应用可足够瞄准神经，而无需准确接触，如使用典型的消融探针时所需要的。例如，可以以很高的、足以使神经组织变性的温度施加离心(eccentric)加热，而不会导致消融，并且无需刺穿腔组织。然而，可能还期望将本发明的能量传送表面配置为刺穿组织并以准确能量剂量像消融探针那样传送消融能量，能量剂量由能量控制和产生装置控制。
电能耗散可依赖于电极阻抗或依赖于电极-组织接触面的阻抗，而不是从有效电极与接地电极之间组织的阻抗耗散。用作说明地，鉴于典型的射频消融治疗可使用具有传导电极的医疗器械，本发明的理念可包括具有一个或多个电阻性电极的电阻性柔性电极组件、包覆在传导电极上的电阻性材料、微加热器和/或其他电阻。使用电阻性柔性电极组件可允许低电压消融装置，这里电能可经由直流电或交流电提供(例如，低压直流电、低频(低于200KHz)交流电、或其他能量)。
在一些实施方式中，去神经治疗的疗效可通过治疗前，治疗中，和/或治疗后测量来评估以对特定患者定制一个或多个治疗参数或者识别是否需要附加治疗。例如，去神经系统可包括用于评估治疗是否已经导致或者正在导致靶组织或邻近组织中神经活动的减少，这可为调节治疗参数提供反馈或者表明附加治疗的必要性。
虽然关于肾神经消融和/或调制讨论了本文描述的装置和方法，可以预期，该装置和方法可用于期望进行神经调制和/或其他组织调制的其他治疗位置和/或应用，包括加热、激活、阻断、破坏、或消融，诸如但不限于：血管、泌尿管、或经由套针和插管进入的其他组织中。例如，本文描述的装置和方法可用于增生组织消融、心脏消融、肺静脉隔离、肺静脉消融、肿瘤消融、良性前列腺增生治疗、神经激发或阻断或消融、肌肉活动调制、组织热疗或其他加热等。
图1是示范肾神经消融系统100的示意图。系统100可包括肾神经消融装置120。肾神经消融装置120可用来消融邻近肾脏K的神经(例如，肾神经，例如，肾动脉RA周围的肾神经)。使用中，肾神经消融装置120可前进穿过诸如主动脉A的血管至肾动脉RA内的位置处。这可包括推进肾神经消融装置120穿过引导鞘套或导管14。当依照要求定位好时，可激活肾神经消融装置120以激活一个或多个电极(未示出)。这可包括可操作地连接肾神经消融装置120至控制单元110，控制单元110可包括射频(RF)发生器，以便供给期望的激活能量至电极。例如，肾神经消融装置120可包括具有连接器20的线或传导部件18，连接器20可连接至控制单元110上的连接器22和/或连结至控制单元110的线24。在至少一些实施方式中，控制单元110还可用来供给/接收适当的电能和/或信号以激活一个或多个设置在肾神经消融装置120远端或远端附近的传感器。当适当地激活时，如以下描述的，电极能够消融组织(例如，肾神经)，并且传感器可用来检测期望的物理和/或生物参数。
在一些实施方式中，肾神经消融装置120可包括细长管状部件或导管杆122，如图2所示。在一些实施方式中，细长管状部件或导管杆122可配置成沿导丝或其他细长医疗器械滑动前进至靶部位。在一些实施方式中，细长管状部件或导管杆122可配置成在引导鞘套或导管14内滑动前进至靶部位。在一些实施方式中，细长管状部件或导管杆122可配置成在导丝上、在引导鞘套或导管14内，或者其组合前进至靶部位。可扩张部件130可设置在细长管状部件或导管杆122的远侧区域中、远侧区域上、远侧区域周围或者远侧区域附近。
例如，如图2所示，在一些实施方式中，电极组件可按照多个大体柱状的治疗区A-D布置在可扩张部件130上，这里可扩张部件130示于扩张状态。在其他实施方式中，可扩张部件130或治疗系统的其他组件可包括附加电极组件，其不在治疗区或者另外不使用或不配置成传送治疗能量。
治疗区A-D和相关联的电极组件140a-d进一步示于图3中，其是图2中可扩张部件130的一部分的“展开”描绘。治疗区A-D可沿纵轴线L-L相互纵向毗邻，并可配置成使电极组件施加的能量产生的治疗不重叠。由纵向相邻的双极电极组件140a-d施加的治疗可沿纵轴线L-L周向非连续。例如，参照图3，在一些实施方式中，治疗区A中产生的毁损灶(lesion)与治疗区B中产生的毁损灶关于周向(在该图中是关于L-L的横向)重叠最小。然而，在其他实施方式中，由电极组件(诸如图3中示出的电极组件)施加的能量可至少在某种程度上纵向、周向，和/或以其他方式重叠。各电极极板组件可包括四个元件，其是远侧电极极板150a-d、中间尾部160a-d、近侧电极极板170a-d和近侧尾部180b、d(未示出电极极板组件140a、140c的近侧尾部)。
图4示出电极组件200的顶视图，其在图3中标识为电极组件140。电极组件200可构建为具有多层的柔性电路。这种层可以是连续或非连续的，即，由离散部分组成。示于图5和6中，绝缘的基层202可提供电极组件200的基座。基层202可由诸如聚酰亚胺的柔性聚合物构建而成，尽管其他材料也可以考虑。由多个离散迹线组成的导电层204可层叠在基层202的顶部。导电层204可以是，例如，电沉积铜的层。也可以考虑其他材料。绝缘层206可离散或连续地层叠在导电层204的顶部，使得导电层204可流体密封在基层202与绝缘层206之间。像基层202一样，绝缘层206可由诸如聚酰亚胺的柔性聚合物构建而成，尽管其他材料也可以考虑。在一些实施方式中，绝缘层206的厚度可以从大约0.01mm到大约0.02mm。在其他实施方式中，绝缘层206可以是完整或部分的聚合物涂层，诸如聚四氟乙烯或硅酮。也可以考虑其他材料。
示于图4中的电极组件200可包括远侧电极极板208。在这个区域中，基层202可形成矩形形状。这并非旨在限制。也可以考虑其他形状。如所示的，电极组件200可包括多个开孔以提供更多的柔性，并且组件的极板和其他部分可包括圆的或弯曲的角，过渡区和其他部分。在一些情况下，开孔和圆的/弯曲的特征可提高组件抵抗与可扩张装置分层的能力，在一些情况下，当可扩张装置反复扩张和塌缩时(这也是可扩张装置从保护鞘套中展开和缩回到保护鞘套中所必需的)，诸如在手术过程中治疗多个部位时可能需要的，分层可能出现。
远侧电极极板208可包括多个层叠在基层202顶部的离散迹线。这些迹线可包括接地迹线210、有源电极迹线(active electrode trace)212和传感器迹线214。接地迹线210可包括从传感器接地极板218横向偏移的细长电极支撑部216。传感器接地极板218可电连结至接地迹线210的细长电极支撑部216，并可位于远侧电极极板208的中心。桥接部220可将传感器接地极板218的最远侧部分连接至接地迹线210的细长电极支撑部216的远侧部分。随着桥接部220行进至传感器接地极板218，桥接部220的宽度可逐渐减小。在一些实施方式中，桥接部220可具有相对一致且细的宽度，使桥接部能够具有期望的柔性量。细长电极支撑部216在它的近端可宽度逐渐减小，然而，这不是必需的。在一些实施方式中，细长电极支撑部216可在它的近侧部分突然转变成细得多的迹线，使其能够具有期望的柔性量。通常，可使迹线的弯曲度(这里显示出颈缩)最优化以降低球囊再俘获力以及任何挂住(可能存在较尖锐的轮廓)的可能性。也可使迹线的形状和位置最优化以提供电极组件200整体的尺寸稳定性，以防止安置和使用过程中的变形。
图5示出远侧电极极板208的局部剖面A-A。电极222层叠在绝缘层206的一部分上，绝缘层206可具有多个通道(例如，孔)使得电极222能够连结至(导电层204的)接地迹线210的细长电极支撑部216。
如图4所示，接地电极迹线210和有源电极迹线212可包括多个电极。可为每个电极迹线设置三个电极222，然而，可使用更多或更少的电极。另外，各电极222可具有倒圆角以降低挂住其他装置和/或组织的可能性。尽管在双极电极组件的情况下描述了电极222和相关联的迹线的以上说明，本领域技术人员应当意识到，相同的电极组件也可作用在单极模式下。例如，作为一个非限制性示例，与有源电极迹线212和242相关联的电极可用作单极电极，在这些电极通电的过程中，接地迹线210断开。
传感器迹线214可位于远侧电极极板208的中心并可包括面向传感器接地极板218的传感器电源极板224。这些极板可连接至温度传感器226的电源极和接地极，诸如热电偶(例如，T型构造：铜/康铜)或热敏电阻，如图6中描绘的局部剖面图所示。
温度传感器226可在近侧连接至传感器电源极板224，并可在远侧连接至传感器接地极板218。为了降低整体厚度，温度传感器226可定位在基层202的开孔中。在一些实施方式中，温度传感器226可以是热敏电阻。如所示的，温度传感器226可以在远侧电极极板208的非组织接触侧。于是，当温度传感器226并入到最终装置(诸如消融装置120)中时，温度传感器226可俘获在电极结构与球囊之间。这可能是有利的，因为表面安装的电子组件(像热敏电阻)通常具有尖锐的边缘和角，其可能钩住组织，并且可能造成球囊展开和/或收回的问题。这种布局也可防止焊接接头接触血液，因为焊料通常是非生物相容性的。而且，由于安置了温度传感器，可测量组织和电极222的温度表示。
从远侧电极极板208开始，结合的基层202、导电层204和绝缘层206的横向宽度可减小直至中间尾部228。这里，导电层204可形成包括中间接地线230、中间有源电极线232和中间传感器线234，其分别是远侧电极极板208的接地迹线210、有效电极迹线212和传感器迹线214共同延伸的迹线。
从中间尾部228开始，结合的基层202、导电层204和绝缘层206的横向宽度可增加以形成近侧电极极板236。近侧电极极板236可类似于远侧电极极板208构建而成，具有基本相同的电极几何形状和温度传感器布局，尽管可存在各种差异。然而，如所示的，近侧电极极板236可关于沿中间接地线230延伸的中心轴线G-G从远侧电极极板208横向偏移。中间有源电极线232和中间传感器线234可在各自平行于中心轴线G-G的轴线上与近侧电极极板236横向共同延伸。
从近侧电极极板236开始，结合的基层202、导电层204和绝缘层206的横向宽度可减小以形成近侧尾部238。近侧尾部238可包括近侧接地线240、近侧有源电极线242和近侧传感器线244，以及中间有源电极线232和中间传感器线234。近侧尾部238可包括连接器(未示出)以使近侧尾部238能够连结至一个或多个子线束和/或连接器，并最终连结至控制单元110。这些线中的每一个可沿各自平行于中心轴线G-G的轴线延伸。
如所示的，电极组件200可具有远侧电极极板208与近侧电极极板236关于轴线G-G不对称的布局。而且，两个电极极板的接地电极连同中间和近侧接地线230/240一起可沿轴线G-G大致对齐。已发现，这种布局可表现出某些优势。例如，由于基本共享同一接地迹线，近侧尾部的宽度可以仅是中间尾部228宽度的大约一点五倍，而不是各电极极板具有独立接地线的情况下的大约两倍宽。这样，近侧尾部238可以比两个中间尾部228更窄。
系统100可用来执行根据本发明一个非限制性实施方式的治疗方法。例如，控制单元110可以可操作地连结至消融装置120，其可插入到体通道中使得可扩张部件130(具有多个电极组件)可放置成邻近需要治疗的体通道的第一段。将消融装置120放置在需要治疗的体通道的第一段可按照传统方法执行，例如，在荧光镜引导下沿着导丝。一旦插入，可扩张部件130可从塌缩递送形态扩张至扩张形态，例如，在球囊的情况下通过大约2-10atm的增压流体。这可造成可扩张部件130的电极和/或电极组件与体通道的第一段形成接触。
使用包括球囊(其具有连结至其上的柔性电路)的医疗器械，例如本文中描述的，可能是令人满意的。然而，在一些情况下，柔性电路可能包括相对刚性的材料。于是，球囊收缩时，柔性电路可能倾向于变平和/或加宽。这样配置时，当将医疗器械(例如，包括柔性电路)从近侧缩回到引导导管中时，柔性电路或其边缘可能钩住引导导管的边缘。本文披露的医疗器械包括在缩回到例如引导导管中时，可降低医疗器械的柔性电路或其他结构“钩住”引导导管(或其他装置)端部的可能性的结构特征。
现在参照图7，肾神经消融装置300可包括可扩张部件130，其可设置在细长管状部件或导管杆122的远侧区域中、远侧区域上、远侧区域周围或远侧区域附近，如上所述。在至少一些实施方式中，可扩张部件130采用球囊的形式。在一些实施方式中，球囊130的近侧腰部136可附装至细长管状部件或导管杆122。
在一些实施方式中，肾神经消融装置300包括一个或多个柔性细长部件310。柔性细长部件310在形式和功能上可类似于本文披露的电极组件和/或柔性电路(例如，电极组件200)。在至少一些实施方式中，柔性细长部件310可附装至可扩张部件130。在一些实施方式中，各细长部件310可包括一个或多个电极组件325。在一些实施方式中，各电极组件325可包括一个或多个接地电极330、一个或多个有源电极335和温度传感器340。在一些实施方式中，各细长部件310可具有从交替侧延伸出的电极组件325，如图7和12A-12D所示。在一些实施方式中，各电极组件325的电极和传感器可如图4所示布置。
球囊130可扩张或者可以其他方式膨胀。球囊130也能够收缩。通常，当可扩张部件130收缩时，球囊130的外形或轮廓可减小。然而，在细长部件310和/或电极组件325包括相对刚性材料的情况下，细长部件310和/或电极组件325可具有收缩时导致球囊130变宽的倾向。这种变宽会导致细长部件310和/或电极组件325在将球囊130缩回到引导导管中时钩住引导导管的端部。
消融装置300还可包括支撑结构380。通常，支撑结构380能够使球囊130朝向折叠形态转换。在至少一些实施方式中，支撑结构380可包括多个支撑元件382。例如，如图7所示，支撑元件382可采用支撑尖齿(tines)的形式，其沿可扩张部件130延伸。支撑元件382可定位在相邻的细长部件310之间。这样，在至少一些实施方式中，支撑元件382和细长部件310可绕球囊130周向交替。在一些实施方式中，支撑元件382接合在它们的远端315和/或它们的近端。然而，这不是必须的，因为可考虑支撑元件382仅仅是沿球囊130延伸的尖齿的实施方式。
在至少一些实施方式中，支撑元件382能够或者以其他方式配置成帮助球囊130朝向折叠形态转换。例如，支撑元件382可形成或另外界定沿球囊130可能发生折叠的区域。这可导致球囊130收缩时开始折叠或者另外帮助球囊130叠起。此外，当球囊130收缩然后缩回到例如引导导管中时，支撑元件382可接合引导导管的远端。当更大的缩回力施加至装置300(以使球囊130缩回到引导导管中)时，支撑元件382与引导导管之间的相互作用可导致球囊130旋转。例如，因为支撑元件382可沿球囊130成一角度，装置300近侧缩回到引导导管中会有导致球囊130在进入引导导管中时旋转的倾向。旋转可有助于进一步减小球囊130的轮廓或者另外帮助再折叠。
在这些实施方式中的一些和其他实施方式中，装置300可包括可帮助球囊130折叠的其他特征。例如，导管杆122的部分或全部可包括扭矩传递结构。这种结构可包括实心管、支撑结构(例如，编织带等)、高扭矩套管(例如，具有在其中形成的狭槽的管状部件)等。
在一些实施方式中，多个细长部件310可扭绞在一起或者与细长部件310的纵轴线L-L成一角度倾斜，如图7和11-12D所示。成一定角度的细长部件310可沿预定折叠线设置或者另外界定预定折叠线，可扩张部件130可在收缩后沿着该预定折叠线折叠。在一些实施方式中，成一定角度的细长部件310帮助可扩张部件130拧在一起及再折叠。
相邻细长部件310上的电极组件325可偏移，如图7所示。在其他实施方式中，电极组件325可沿可扩张部件130的长度具有螺旋取向，电极组件325可在可扩张部件130定位的腔或血管中形成至少一个完整(360度)的周向环。电极组件325可在围绕体通道的组织中的位置处提供加热，而不会损伤体通道的壁，以破坏位于围绕体通道壁的组织中的神经。螺旋取向是可取的有助于避免电极设置在垂直于体通道纵轴线的单个平面中时(即，环形电极或电极组)可能存在的狭窄增加的风险。
在一些实施方式中，可扩张部件130具有一个或多个沿可扩张部件130的长度延伸的通道134，如图8所示。通道134配置成在可扩张部件130扩张时保留。当可扩张部件130安置在诸如血管的体腔内并扩张时，通道134可允许部分流体流动越过可扩张部件130。通道134可绕可扩张部件130螺旋设置。在示出的实施方式中，可扩张部件130具有三个沿可扩张部件130螺旋延伸的通道134。这并不旨在限制。任何数量的通道134可包含在可扩张部件130中，包括一个、两个、三个、四个、五个、六个或更多的。通道134可以以允许柔性细长部件310设置在通道134之间的方式隔开。在一些实施方式中，细长部件310以匹配通道134的角度的方式螺旋延伸。通道134可提供预定折叠线，可扩张部件130在收缩后沿该预订折叠线折叠。在一些实施方式中，成一定角度的通道134帮助可扩张部件130拧在一起及再折叠。在一些实施方式中，柔性细长部件310安装在通道134内。通道134的宽度可调节以容纳细长部件310和电极组件325。在一些实施方式中，通道134可以是开放/未填充的并在使用过程中保持是开放/未填充的。在其他实施方式中，支撑元件382可设置在通道134内。
如图9所示，肾神经消融装置300可包括支撑结构380。支撑结构380可包括多个支撑元件382。在一些实施方式中，支撑元件382可在它们的近端384和它们的远端386处相互连接。在一些实施方式中，支撑元件382可连接至连接部件或环(未示出)。在一些实施方式中，支撑元件382的远端386可附装至可扩张部件130的远侧腰部137，并且支撑元件382的近端384可附装至可扩张部件130的近侧腰部136。在其他实施方式中，支撑元件382的远端386和近端384可附装至导管杆122。远端386可相互连接，但保持自由附装至导管杆122和可扩张部件130。远端386可滑动地设置在可扩张部件130的远侧腰部137周围。
在一些实施方式中，支撑元件382可大致平行于可扩张部件130的纵轴线延伸。在一些实施方式中，支撑元件382可沿可扩张部件的主体135与纵轴线成一角度延伸。见图9-10。在可扩张部件130具有通道134的实施方式中，支撑元件382可设置在通道中。见图10。在一些实施方式中，支撑结构380可由诸如镍钛诺的镍钛合金制成。在其他实施方式中，支撑结构380可由聚合物制成。
在一些实施方式中，可扩张部件130是模制球囊，并且在制造过程中，支撑结构380可集成到球囊中。例如，支撑结构380可插入到球囊模中，球囊管可插入到模中的支撑元件中。然后可使用传统工艺吹胀球囊，将支撑结构380和可扩张部件130集成到单个增强的球囊组件中。在一些实施方式中，支撑结构380可在可扩张部件130形成之后附装至可扩张部件130。
支撑结构380可为可扩张部件130提供增强的收缩和再折叠特性。当可扩张部件130收缩和/或退回到引导导管14中时，支撑结构380可提供预定线，可扩张部件130沿该线再折叠。支撑结构380可允许可扩张部件130以预定方式再折叠，并允许可扩张部件130一致且完整的再折叠。支撑结构380可以以避免或降低细长部件310分层的方式协助可扩张部件130再折叠。预定折叠且没有分层可允许装置300退回到引导导管14中用于在第二个位置的重新安置处。在一些实施方式中，柔性细长部件310可安装在支撑元件382上。
在一些实施方式中，支撑结构380可导电。在一些实施方式中，支撑元件382可分开并起到电极的作用，一些支撑元件为正，一些为负。在这种实施方式中，电极组件325可由导电的支撑元件382替代。例如，电极组件325可电连接至支撑元件382。这可允许在装置300的制造过程中使用较少的组件。在其他实施方式中，电极组件325可直接安装在球囊130的通道134内。这些仅是示例。可考虑其他的实施方式。
现在参照图11-12D，柔性细长部件310-310h可以相对于纵轴线L-L以各种取向附装至可扩张部件130的主体。图11示出可扩张部件130上成一定角度的细长部件310a-310c的示范组。图12A示出图11中处于扁平、展开形态的可扩张部件130。在一些实施方式中，一个或多个细长部件310a-310c可具有弯曲部322，在该弯曲部322，细长部件从在近侧区域320平行于纵轴线L-L过渡至成一定角度取向的310a、310b、310c。在一些实施方式中，各个成一定角度的细长部件310a-310c可具有长度不同的近侧区域320。在一些实施方式中，两个以上电极组件325可从两侧横向延伸至细长部件310。例如，图12A和12B示出一组各具有两个电极组件325的成一定角度的细长部件310a-310f，这里电极组件325从细长部件310a-310f沿相反方向延伸出。在一些实施方式中，诸如图12C中所示，一个或多个细长部件310可沿其长度大致直线的，沿其整个长度与纵轴线成一定角度延伸。在一些实施方式中，可扩张部件130可具有大致直线的细长部件310和成一定角度的细长部件310g、310h的混合。在一些实施方式中，诸如图7和图12D中所示的，所有细长部件310可沿其长度大致直线的，沿可扩张部件130的整个长度与纵轴线成一定角度延伸。
成一定角度的细长部件310a-310h可导致球囊旋转并沿成一定角度的细长部件310a-310h的线折叠，降低了使消融装置300退回到引导鞘套或导管14中所需要的退回力，并允许使用更小直径的引导鞘套。例如，可使用6Fr的引导导管14，在肾手术中提供优势，而不是之前使用的8Fr的引导导管。成一定角度的细长部件310a-310h可降低剪力(shearforce)，因此降低了细长部件与可扩张部件130分层的可能性。在一些实施方式中，细长部件310a-310f与电极组件325的近侧边缘336之间的过渡是渐进的，如图11、12A和8B所示。渐进过渡可降低消融装置300退回到引导导管14中时近侧边缘336钩到引导导管14并导致分层的可能性。
在一些实施方式中，肾神经消融装置300可包括双极电极对。当肾神经消融装置300通电时，诸如以上述方式，射频能量或其他合适的能量可从有源电极335经过，穿过血管壁和靶组织(例如，肾神经)，至接地电极330，因此产生了相应的沿体通道(可扩张部件130已定位在其内)的一个或多个毁损灶。传感器元件340可定位在接地电极330和有源电极335之间。传感器元件340可包括至少一个定位在可扩张部件130的外表面上的温度传感器，诸如热敏电阻或热电偶。该至少一个温度传感器340可定位在接地电极330和有源电极335之间，并可配置成监测靶组织、有源和接地电极、或两者的温度，如上所述。在一些实施方式中，在沿可扩张部件130长度的多个位置处，至少一个温度传感器340可包括多个配置成监测靶组织、有源电极、接地电极、或其任何组合的温度的温度传感器。
使用中，可推进消融装置300通过血管至邻近靶组织(例如，肾动脉内)的位置处。在一些实施方式中，靶组织可以是一个或多个在肾动脉周围的肾神经。当合适定位时，可扩张部件130可从塌缩递送形态扩张至扩张形态。这可将有源电极335放置成抵住血管壁。可激活有源电极335。消融能量可从有源电极335通过靶组织(在这里肾神经可被消融、调制、或以其他方式受到影响)传递，并通过接地电极330返回(在双极配置下)，或者通过共用的接地电极返回(在单极配置下)。
可用于消融装置300(和/或本文披露的其他装置)的各种组件的材料可包括那些通常与医疗器械相关的材料。为简明起见，以下谈论参照消融装置300。然而，这并不旨在限制本文公开的装置和方法，因为讨论可适用于其他类似的管状部件和/或可扩张部件和/或本文公开的管状部件和/或可扩张部件的组件。
消融装置300及其各种组件可由金属，金属合金，聚合物(下文公开了其一些示例)，金属-聚合物复合物，陶瓷，及其组合等，或者其他合适的材料。合适的聚合物的一些示例可包括聚四氟乙烯(PTFE)，乙烯-四氟乙烯(ETFE)，氟化乙烯丙烯(FEP)，聚氧甲烯(POM，例如，杜邦公司出售的)，聚醚嵌段酯，聚氨酯(例如，聚氨酯85A)，聚丙烯(PP)，聚氯乙烯(PVC)，聚醚酯(例如，DSM工程塑料公司出售的)，醚基或酯基共聚物(例如，丁烯/聚(亚烃基醚)邻苯二甲酸酯和/或诸如杜邦公司出售的的聚酯弹性体)，聚酰胺(例如，拜尔公司出售的或埃尔夫阿托公司出售的)，弹性体聚酰胺，嵌段聚酰胺/醚，聚醚嵌段酰胺(PEBA，例如以为商标名出售的产品)，乙烯-乙酸乙烯酯共聚物(EVA)，硅树脂，聚乙烯(PE)，马勒克斯高密度聚乙烯，马勒克斯低密度聚乙烯，线性低密度聚乙烯(例如，)，聚酯，聚对苯二甲酸丁二醇酯(PBT)，聚对苯二甲酸乙二醇酯(PET)，聚对苯二甲酸丙二醇酯(polytrimethylene terephthalate)，聚萘二甲酸乙二醇酯(PEN)，聚醚醚酮(PEEK)，聚酰亚胺(PI)，聚醚酰亚胺(PEI)，聚苯硫醚(PPS)，聚苯醚(PPO)，聚对苯二甲酰对苯二胺(例如，)，聚砜，尼龙，尼龙-12(诸如EMS American Grilon公司出售的)，全氟(丙基乙烯基醚)(PFA)，乙烯基乙烯醇，聚烯烃，聚苯乙烯，环氧树脂，聚偏二氯乙烯(PVdC)，聚(苯乙烯-b-异丁烯-b-苯乙烯)(例如，SIBS及/或SIBS 50A)，聚碳酸脂，离聚物，生物相容聚合物，其他适材料，或者前述材料的混合物，组合物，共聚物，聚合物/金属组合物，等等。在一些实施方式中，鞘套可与液晶聚合物(LCP)混合。例如，混合物可包含高达大约6％的LCP。
合适的金属和金属合金的一些示例包括诸如304V，304L，和316LV不锈钢的不锈钢；软钢；诸如线弹性和/或超弹性镍钛诺的镍-钛合金；诸如镍-铬-钼合金(例如，诸如625的UNS:N06625，诸如 的UNS:N06022，诸如的UNS:N10276，其他合金等)的其他镍合金，镍-铜合金(例如，诸如400，400，400等的UNS:N04400)，镍-钴-铬-钼合金(例如，诸如等的UNS:R30035)，镍-钼合金(例如，诸如的UNS:N10665)，其他镍-铬合金，其他镍-钼合金，其他镍-钴合金，其他镍-铁合金，其他镍-铜合金，其他镍-钨合金或钨合金等；钴-铬合金；钴-铬-钼合金(例如，诸如等的UNS:R30003)；铂富集不锈钢；钛；及其组合等；或者任何其他合适的材料。
如本文提到的，在市售镍-钛或镍钛诺合金的家族里，有称作“线弹性”或“非超弹性”的种类，尽管其在化学性质方面类似于常见的形状记忆和超弹性种类，但其可呈现出独特且有益的机械性能。线弹性和/或非超弹性镍钛诺与超弹性镍钛诺的区别可在于，线弹性和/或非超弹性镍钛诺在应力/应变曲线中不具有实质的“超弹性坪(superelasticplateau)”或“标志区域(flag region)”，而超弹性镍钛诺则具有。相反，在线弹性和/或非超弹性镍钛诺中，随着可恢复应变增大，应力以大致线性，或稍微线性，但不必完全线性的关系持续增大直至塑性变形开始或者至少以比超弹性镍钛诺所示的超弹性坪和/或标志区域更为线性的关系。这样，为了本公开的目的，线弹性和/或非超弹性镍钛诺也可称为“大致”线弹性和/或非超弹性镍钛诺。
在一些情况下，线弹性和/或非超弹性镍钛诺与超弹性镍钛诺的区别也可在于，线弹性和/或非超弹性镍钛诺可在保持大致弹性的同时承受多达大约2-5％的应变(例如，在塑性变形之前)，而超弹性镍钛诺在塑性变形之前可承受多达大约8％的应变。这两种材料都能够与诸如不锈钢的其他线弹性材料(其也能够根据组分而区别开)区别开，其他线弹性材料在塑性变形之前仅可承受大约0.2到0.44％的应变。
在一些实施方式中，线弹性和/或非超弹性镍-钛合金是不具有任何马氏体相变/奥氏体相变的合金，相变可通过差示扫描量热仪(DSC)和动态金属热分析(DMTA)在很大的温度范围内进行分析而检测得到。例如，在一些实施方式中，在大约-60摄氏度(℃)到大约120℃的范围内通过差示扫描量热仪(DSC)和动态金属热分析(DMTA)未测得线弹性和/或非超弹性镍-钛合金的马氏体相变/奥氏体相变。因此，在这个非常宽广的温度范围内，这种材料的机械弯曲性能通常不会受到温度的影响。在一些实施方式中，线弹性和/或非超弹性镍-钛合金在环境温度或室温下的机械弯曲性能与在体温下的机械性能基本相同，例如，都不显示超弹性坪和/或标志区域。换句话说，在宽广的温度范围内，线弹性和/或非超弹性镍-钛合金保持其线弹性和/或非超弹性特性和/或性能。
在一些实施方式中，线弹性和/或非超弹性镍-钛合金中镍的重量百分比可在大约50到大约60的范围内，其余部分基本为钛。在一些实施方式中，镍的重量百分比在大约54到大约57的范围内。合适的镍-钛合金的一个示例是日本神奈川县的Furukawa TechnoMaterial Co.销售的FHP-NT合金。在美国专利第5,238,004号和6,508,803号中公开了镍钛合金的一些示例，通过引用将其合并在此。其他合适的材料可包括ULTANIUMTM(可从Neo-Metrics公司购买)和GUM METALTM(可从丰田公司购买)。在一些其他的实施方式中，超弹性合金(例如超弹性镍钛诺)能够用来实现期望的性能。
在至少一些实施方式中，消融装置300的部分也可掺杂有，材料为，或包括不透射线的材料。不透射线的材料理解为能够在医疗过程中在荧光透视屏或其他成像技术上生成相对较亮图像的材料。这个相对较亮的图像可帮助消融装置300的使用者判定其位置。不透射线的材料的一些示例能够包括但不限于，金，铂，钯，钽，钨合金，装有不透射线填料的聚合物材料等。此外，其他不透射线的标记带和/或线圈也可包括在消融装置300的设计中以实现相同的结果。
在一些实施方式中，给予消融装置300一定程度的磁共振成像(MRI)兼容性。例如，装置的部分可由基本不使图像失真及不生成实质伪影(即，图像中的间隙)的材料制成。例如，某些铁磁材料可能不适合，因为它们会在MRI图像中生成伪影。在这些实施方式中的一些或其他实施方式中，消融装置300的部分也可由MRI机器能够成像的材料制成。显示出这些特性的一些材料包括，例如钨，钴-铬-钼合金(例如，诸如等的UNS:R30003)，镍-钴-铬-钼合金(例如，诸如等的UNS:R30035)，镍钛诺等，以及其他材料。
2013年1月25日提交的、名为“Methods And Apparatuses For RemodelingTissue Of Or Adjacent To A Body Passage”的美国专利申请序号第13/750,879号，现在公布为美国专利公告第US20130165926A1号，通过引用合并在此。///
附加实施方式
公开了用于肾神经消融的医疗器械。该医疗器械包括导管杆。可扩张球囊连接至导管杆，球囊能够在折叠形态和扩张形态之间转换。支撑结构连接至球囊，支撑结构能够使球囊朝向折叠形态转换。多个细长柔性电极组件设置在球囊上，其中细长柔性电极组件相对于球囊的纵轴线成一角度取向。
作为上述任一实施方式的替代或附加，支撑结构包括多个沿球囊延伸的细长支撑元件。
作为上述任一实施方式的替代或附加，柔性细长电极组件中的至少一些设置在细长支撑元件之间。
作为上述任一实施方式的替代或附加，多个细长支撑元件包含镍钛合金。
作为上述任一实施方式的替代或附加，多个细长支撑元件包含聚合物。
作为上述任一实施方式的替代或附加，电极组件中的至少一些包括成对的相邻双极电极。
作为上述任一实施方式的替代或附加，电极组件中的至少一些包括单极电极。
作为上述任一实施方式的替代或附加，电极组件中的至少一些包括温度传感器。
作为上述任一实施方式的替代或附加，温度传感器定位在其中一个电极组件的底面与球囊的外表面之间。
作为上述任一实施方式的替代或附加，细长柔性电极组件中的至少一个具有平行于球囊的纵轴线延伸的近侧部分，和弯曲部分，在所述弯曲部分，细长柔性电极组件成一角度远离球囊的纵轴线。
作为上述任一实施方式的替代或附加，各细长柔性电极组件的近侧部分具有不同的长度。
作为上述任一实施方式的替代或附加，多个柔性电极组件中的每一个的弯曲部分相对于球囊的纵轴线以相同的角度取向。
作为上述任一实施方式的替代或附加，一个或多个细长柔性电极组件沿其长度大致直线延伸，并与球囊的纵轴线成一角度。
作为上述任一实施方式的替代或附加，所有的细长柔性电极组件沿其长度大致直线延伸，并与球囊的纵轴线成一角度。
作为上述任一实施方式的替代或附加，球囊包括多个在其中形成的通道，所述通道相对于球囊的纵轴线成一角度延伸。
作为上述任一实施方式的替代或附加，多个细长柔性电极组件与多个通道交替。
作为上述任一实施方式的替代或附加，多个细长柔性电极组件与多个通道相对于球囊的纵轴线以相同角度延伸。
作为上述任一实施方式的替代或附加，多个细长柔性电极组件设置在多个通道中。
作为上述任一实施方式的替代或附加，支撑结构包括多个沿球囊延伸的细长支撑元件，其中各支撑元件设置在通道中。
公开了用于肾神经消融的医疗器械。该医疗器械包括导管杆。可扩张球囊连接至导管杆，球囊具有近端和远端，并具有在近端和远端之间延伸的长度。支撑结构连接至球囊，支撑结构能够使球囊在缩回到引导导管中时以预定方式折叠。多个柔性电极组件连接至支撑结构。
作为上述任一实施方式的替代或附加，支撑结构包括多个沿球囊的长度延伸的细长支撑元件。
作为上述任一实施方式的替代或附加，细长支撑元件沿球囊的长度与球囊的纵轴线成一角度延伸。
作为上述任一实施方式的替代或附加，球囊包括多个沿长度延伸的通道。
作为上述任一实施方式的替代或附加，细长支撑元件设置在通道中。
作为上述任一实施方式的替代或附加，通道和细长支撑元件沿球囊的长度与球囊的纵轴线成一角度延伸。
作为上述任一实施方式的替代或附加，电极组件沿纵向偏移。
作为上述任一实施方式的替代或附加，电极组件中的至少一些包括成对的相邻双极电极。
作为上述任一实施方式的替代或附加，电极组件中的至少一些包括单极电极。
作为上述任一实施方式的替代或附加，电极组件中的至少一些包括温度传感器。
作为上述任一实施方式的替代或附加，球囊是顺应性球囊。
作为上述任一实施方式的替代或附加，球囊是非顺应性球囊。
作为上述任一实施方式的替代或附加，支撑结构在可扩张球囊的主体上以螺旋结构延伸。
公开了消融肾神经的示范方法。该方法包括推进医疗器械通过引导导管并进入血管至肾动脉内的位置处。该医疗器械包括导管杆，连结至导管杆的可扩张球囊，球囊能够在折叠形态和扩张形态之间转换，连结至球囊的支撑结构，支撑结构能够使球囊朝向折叠形态转换，以及多个设置在球囊上的细长柔性电极组件，其中细长柔性电极组件相对于球囊的纵轴线成一角度取向。该方法还包括扩张球囊，激活细长柔性电极组件中的至少一些，以及将球囊缩回到引导导管中，其中支撑结构与引导导管之间的相互作用使球囊转换至折叠形态。
作为上述任一实施方式的替代或附加，电极组件中的至少一些包括电阻性部件。
作为上述任一实施方式的替代或附加，电阻性部件构成微加热器。
应当理解，本发明在许多方面仅是说明性的。在不超出本发明范围的情况下，可详细作出改变，特别是在形状，尺寸，和步骤布局方面。在某种适当的程度上，这可包括将一个示范性实施方式的特征中的任何一个用在其他实施方式中。当然，本发明的范围由所附的权利要求表示。

Claims (26)

1.用于肾神经消融的医疗器械，包括：
导管杆；
连接至所述导管杆的可扩张球囊，所述球囊具有近端和远端，并具有在所述近端和所述远端之间延伸的长度，并且所述球囊包括多个沿球囊的长度延伸的通道；
连接至所述球囊的支撑结构，所述支撑结构构造成在缩回球囊和所述支撑结构进入引导导管时以预定方式扭绞并折叠球囊，并且所述支撑结构包括多个沿所述球囊的长度延伸的细长支撑元件，所述细长支撑元件设置在所述通道中；以及
多个柔性电极组件，其连接至所述球囊、在所述通道之间。
2.根据权利要求1所述的医疗器械，其中所述细长支撑元件在其近端彼此连接，并且其中所述细长支撑元件沿所述球囊的长度延伸并与所述球囊的纵轴线成一角度扭绞。
3.根据权利要求1所述的医疗器械，其中所述细长支撑元件在其近端彼此连接，并且其中所述通道和所述细长支撑元件沿所述球囊的长度延伸并与所述球囊的纵轴线成一角度扭绞。
4.根据权利要求1-3中任一所述的医疗器械，其中所述电极组件纵向地偏移。
5.根据权利要求1-3中任一所述的医疗器械，其中所述电极组件中的至少一些包括成对的相邻双极电极。
6.根据权利要求1-3中任一所述的医疗器械，其中所述电极组件中的至少一些包括单极电极。
7.根据权利要求1-3中任一所述的医疗器械，其中所述电极组件中的至少一些包括温度传感器。
8.根据权利要求1-3中任一所述的医疗器械，其中所述球囊是顺应性球囊。
9.根据权利要求1-3中任一所述的医疗器械，其中所述球囊是非顺应性球囊。
10.根据权利要求1-3中任一所述的医疗器械，其中所述细长支撑元件在其近端连接在一起并沿所述球囊的主体以螺旋结构延伸。
11.用于肾神经消融的医疗器械，包括：
导管杆；
连接至所述导管杆的可扩张球囊，所述球囊能够在折叠形态和扩张形态之间转换，并且所述球囊包括沿球囊的长度延伸的多个通道；
连接至所述球囊的支撑结构，所述支撑结构包括沿所述球囊的长度延伸的多个细长支撑元件，所述多个细长支撑元件设置在所述多个通道中，并且所述支撑结构构造成在缩回球囊和支撑结构进入引导导管时使所述球囊扭绞和折叠；以及
设置在所述球囊上所述多个通道之间的多个细长柔性电极组件，其中所述多个细长柔性电极组件相对于所述球囊的纵轴线成一角度扭绞。
12.根据权利要求11所述的医疗器械，其中所述多个细长柔性电极组件中的至少一些设置在所述细长支撑元件之间。
13.根据权利要求11-12中任一所述的医疗器械，其中所述多个细长支撑元件包含镍钛合金。
14.根据权利要求11-12中任一所述的医疗器械，其中所述多个细长支撑元件包含聚合物。
15.根据权利要求11-12中任一所述的医疗器械，其中所述多个细长柔性电极组件中的至少一些包括成对的相邻双极电极。
16.根据权利要求11-12中任一所述的医疗器械，其中所述多个细长柔性电极组件中的至少一些包括单极电极。
17.根据权利要求11-12中任一所述的医疗器械，其中所述多个细长柔性电极组件中的至少一些包括温度传感器。
18.根据权利要求17所述的医疗器械，其中所述温度传感器定位在其中一个所述细长柔性电极组件的底面与所述球囊的外表面之间。
19.根据权利要求11-12中任一所述的医疗器械，其中所述细长柔性电极组件中的至少一个具有近侧部分和弯曲部分，所述近侧部分平行于所述球囊的所述纵轴线延伸，所述细长柔性电极组件在所述弯曲部分成一角度远离所述球囊的所述纵轴线。
20.根据权利要求19所述的医疗器械，其中所述细长柔性电极组件中的每一个的所述近侧部分具有不同的长度。
21.根据权利要求20所述的医疗器械，其中所述细长柔性电极组件中的每一个的所述弯曲部分相对于所述球囊的所述纵轴线以相同的角度取向。
22.根据权利要求11-12中任一所述的医疗器械，其中所述多个细长柔性电极组件中的一个以上沿其长度基本直线延伸，并与所述球囊的所述纵轴线成一角度。
23.根据权利要求22所述的医疗器械，其中所述多个细长柔性电极组件全部沿其长度与所述球囊的所述纵轴线成一角度大致直线延伸。
24.根据权利要求11-12中任一所述的医疗器械，其中所述多个通道相对于所述球囊的所述纵轴线成一角度延伸。
25.根据权利要求24所述的医疗器械，其中所述多个细长柔性电极组件与所述多个通道交替。
26.根据权利要求24所述的医疗器械，其中所述多个细长柔性电极组件与所述多个通道相对于所述球囊的所述纵轴线以相同角度延伸。
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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US11376061B2 (en) 2008-11-11 2022-07-05 Covidien Lp Energy delivery device and methods of use
CA2832311A1 (en) 2011-04-08 2012-11-29 Covidien Lp Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
CN103930061B (zh) 2011-04-25 2016-09-14 美敦力阿迪安卢森堡有限责任公司 用于限制导管壁低温消融的有关低温球囊限制部署的装置及方法
WO2013086461A1 (en) 2011-12-09 2013-06-13 Metavention, Inc. Therapeutic neuromodulation of the hepatic system
US10828090B2 (en) 2014-01-10 2020-11-10 Boston Scientific Scimed, Inc. Medical devices with flexible circuit assemblies
US10709490B2 (en) 2014-05-07 2020-07-14 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies comprising a direct heating element for renal neuromodulation and associated systems and methods
US20160058502A1 (en) * 2014-08-27 2016-03-03 Boston Scientific Scimed, Inc. Devices for damaging nerves and related methods of use
US20180279955A1 (en) 2015-05-07 2018-10-04 Ecom Medical, Inc. Systems and methods for internal ecg acquisition
DE102016106478A1 (de) * 2016-04-08 2017-10-12 Biotronik Ag Vorrichtung zur Energieabgabe und/oder Messung von elektrischer Aktivität
US10660700B2 (en) * 2016-04-28 2020-05-26 Biosense Webster (Israel) Ltd. Irrigated balloon catheter with flexible circuit electrode assembly
US10524859B2 (en) 2016-06-07 2020-01-07 Metavention, Inc. Therapeutic tissue modulation devices and methods
US11400205B2 (en) 2016-11-23 2022-08-02 Biosense Webster (Israel) Ltd. Balloon-in-balloon irrigation balloon catheter
US20180161093A1 (en) * 2016-12-08 2018-06-14 Biosense Webster (Israel) Ltd. Irrigated balloon catheter with support spines and variable shape
US20190059818A1 (en) 2017-08-29 2019-02-28 Biosense Webster (Israel) Ltd. Balloon advancement mechanism
WO2020028179A1 (en) * 2018-07-30 2020-02-06 Csa Medical, Inc. Devices and methods for energy transfer mapping
WO2020065587A2 (en) * 2018-09-27 2020-04-02 St. Jude Medical, Cardiology Division, Inc. Uniform mapping balloon
US20200205887A1 (en) * 2018-12-27 2020-07-02 Biosense Webster (Israel) Ltd. Ablation Balloon Catheter Allowing Blood Flow
CN114404024B (zh) * 2019-09-03 2024-01-05 深圳北芯医疗科技有限公司 用于冷冻消融装置的伸缩导丝
US11957852B2 (en) 2021-01-14 2024-04-16 Biosense Webster (Israel) Ltd. Intravascular balloon with slidable central irrigation tube
CN117838247A (zh) * 2021-11-09 2024-04-09 上海蓝帆博元医疗科技有限公司 一种冲击波电极组件、球囊导管装置以及医疗设备

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6142993A (en) * 1998-02-27 2000-11-07 Ep Technologies, Inc. Collapsible spline structure using a balloon as an expanding actuator
CN202723978U (zh) * 2012-02-02 2013-02-13 北京中孵友信医药科技股份有限公司 一种用于特殊治疗的腔内导管
CN103027750A (zh) * 2012-11-23 2013-04-10 刘宗军 一种经皮肾动脉内电消融球囊射频导管
CN203017083U (zh) * 2012-12-31 2013-06-26 上海微创电生理医疗科技有限公司 多电极消融导管

Family Cites Families (1230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US164184A (en) 1875-06-08 Improvement in vesicular electrodes
US852787A (en) 1906-04-02 1907-05-07 Arthur G Hoerner Ironing-board.
US921973A (en) 1908-11-17 1909-05-18 L T Gillett Device for coupling and uncoupling sectional metallic pipe-lines.
US976733A (en) 1910-05-25 1910-11-22 Maria A Gilliland Skimmer.
US1167014A (en) 1915-06-25 1916-01-04 William R O'brien Veterinary surgical instrument.
US2505358A (en) 1949-04-20 1950-04-25 Sklar Mfg Co Inc J Double-cutting biopsy bistoury
US2701559A (en) 1951-08-02 1955-02-08 William A Cooper Apparatus for exfoliating and collecting diagnostic material from inner walls of hollow viscera
US3108593A (en) 1961-03-13 1963-10-29 Jacob A Glassman Surgical extractor
US3108594A (en) 1962-08-14 1963-10-29 Jacob A Glassman Surgical extractor and method of use
US3540431A (en) 1968-04-04 1970-11-17 Kazi Mobin Uddin Collapsible filter for fluid flowing in closed passageway
US6014590A (en) 1974-03-04 2000-01-11 Ep Technologies, Inc. Systems and methods employing structures having asymmetric mechanical properties to support diagnostic or therapeutic elements in contact with tissue in interior body regions
US3952747A (en) 1974-03-28 1976-04-27 Kimmell Jr Garman O Filter and filter insertion instrument
US3996938A (en) 1975-07-10 1976-12-14 Clark Iii William T Expanding mesh catheter
US4046150A (en) 1975-07-17 1977-09-06 American Hospital Supply Corporation Medical instrument for locating and removing occlusive objects
US4290427A (en) 1979-11-26 1981-09-22 Thomas J. Fogarty Endarterectomy apparatus
US4402686A (en) 1981-07-09 1983-09-06 Medel Gonzalo A Pinched nerve instrument
US4483341A (en) 1982-12-09 1984-11-20 Atlantic Richfield Company Therapeutic hypothermia instrument
US4784132A (en) 1983-03-25 1988-11-15 Fox Kenneth R Method of and apparatus for laser treatment of body lumens
US4531943A (en) 1983-08-08 1985-07-30 Angiomedics Corporation Catheter with soft deformable tip
EP0152766A1 (en) 1984-01-24 1985-08-28 Shiley Incorporated Reduction of an arteriosclerotic lesion by selective absorption of electromagnetic energy in a component thereof
US4574804A (en) 1984-02-27 1986-03-11 Board Of Regents, The University Of Texas System Optic nerve clamp
US4682596A (en) 1984-05-22 1987-07-28 Cordis Corporation Electrosurgical catheter and method for vascular applications
US4587975A (en) 1984-07-02 1986-05-13 Cardiac Pacemakers, Inc. Dimension sensitive angioplasty catheter
US5143836A (en) 1984-08-27 1992-09-01 Bio-Technology General Corp. Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda pl promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
US6030611A (en) 1984-08-27 2000-02-29 Bio-Technology General Corp. Therapeutic SOD compositions and uses thereof
US5162217A (en) 1984-08-27 1992-11-10 Bio-Technology General Corp. Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda PL promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
US4649936A (en) 1984-10-11 1987-03-17 Case Western Reserve University Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking
US4799479A (en) 1984-10-24 1989-01-24 The Beth Israel Hospital Association Method and apparatus for angioplasty
US5034010A (en) 1985-03-22 1991-07-23 Massachusetts Institute Of Technology Optical shield for a laser catheter
US5693043A (en) 1985-03-22 1997-12-02 Massachusetts Institute Of Technology Catheter for laser angiosurgery
US20020045811A1 (en) 1985-03-22 2002-04-18 Carter Kittrell Laser ablation process and apparatus
US5318024A (en) 1985-03-22 1994-06-07 Massachusetts Institute Of Technology Laser endoscope for spectroscopic imaging
US4862886A (en) 1985-05-08 1989-09-05 Summit Technology Inc. Laser angioplasty
US4709698A (en) 1986-05-14 1987-12-01 Thomas J. Fogarty Heatable dilation catheter
GB8622797D0 (en) 1986-09-22 1986-10-29 Allied Colloids Ltd Polymeric particles
US4784162A (en) 1986-09-23 1988-11-15 Advanced Medical Technologies Portable, multi-channel, physiological data monitoring system
US5231995A (en) 1986-11-14 1993-08-03 Desai Jawahar M Method for catheter mapping and ablation
US4785806A (en) 1987-01-08 1988-11-22 Yale University Laser ablation process and apparatus
US4790310A (en) 1987-02-04 1988-12-13 Robert Ginsburg Laser catheter having wide angle sweep
US4765331A (en) 1987-02-10 1988-08-23 Circon Corporation Electrosurgical device with treatment arc of less than 360 degrees
US4823791A (en) 1987-05-08 1989-04-25 Circon Acmi Division Of Circon Corporation Electrosurgical probe apparatus
US4770653A (en) 1987-06-25 1988-09-13 Medilase, Inc. Laser angioplasty
US4938766A (en) 1987-08-28 1990-07-03 Jarvik Robert K Prosthetic compliance devices
US5154705A (en) 1987-09-30 1992-10-13 Lake Region Manufacturing Co., Inc. Hollow lumen cable apparatus
US4788975B1 (en) 1987-11-05 1999-03-02 Trimedyne Inc Control system and method for improved laser angioplasty
US4887605A (en) 1988-02-18 1989-12-19 Angelsen Bjorn A J Laser catheter delivery system for controlled atheroma ablation combining laser angioplasty and intra-arterial ultrasonic imagining
US4890623A (en) 1988-03-14 1990-01-02 C. R. Bard, Inc. Biopotential sensing device and method for making
US5372138A (en) 1988-03-21 1994-12-13 Boston Scientific Corporation Acousting imaging catheters and the like
US5178620A (en) 1988-06-10 1993-01-12 Advanced Angioplasty Products, Inc. Thermal dilatation catheter and method
US4830003A (en) 1988-06-17 1989-05-16 Wolff Rodney G Compressive stent and delivery system
JP2836878B2 (ja) 1988-08-24 1998-12-14 スリピアン，マービン，ジェイ 生分解性高分子材料による管腔内封止
US4920979A (en) 1988-10-12 1990-05-01 Huntington Medical Research Institute Bidirectional helical electrode for nerve stimulation
US6066130A (en) 1988-10-24 2000-05-23 The General Hospital Corporation Delivering laser energy
US4955377A (en) 1988-10-28 1990-09-11 Lennox Charles D Device and method for heating tissue in a patient's body
US5150717A (en) 1988-11-10 1992-09-29 Arye Rosen Microwave aided balloon angioplasty with guide filament
WO1990006718A1 (en) 1988-12-21 1990-06-28 Massachusetts Institute Of Technology A method for laser induced fluorescence of tissue
US5697369A (en) 1988-12-22 1997-12-16 Biofield Corp. Method and apparatus for disease, injury and bodily condition screening or sensing
AU4945490A (en) 1989-01-06 1990-08-01 Angioplasty Systems Inc. Electrosurgical catheter for resolving atherosclerotic plaque
US5749914A (en) 1989-01-06 1998-05-12 Advanced Coronary Intervention Catheter for obstructed stent
US5779698A (en) * 1989-01-18 1998-07-14 Applied Medical Resources Corporation Angioplasty catheter system and method for making same
US5052402A (en) 1989-01-31 1991-10-01 C.R. Bard, Inc. Disposable biopsy forceps
US5453091A (en) 1989-03-17 1995-09-26 Merit Medical Systems, Inc. RF transmission module for wirelessly transmitting balloon catheter data in a syringe inflation system
US5098431A (en) 1989-04-13 1992-03-24 Everest Medical Corporation RF ablation catheter
US4976711A (en) 1989-04-13 1990-12-11 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5125928A (en) 1989-04-13 1992-06-30 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5211651A (en) 1989-08-18 1993-05-18 Evi Corporation Catheter atherotome
US5282484A (en) 1989-08-18 1994-02-01 Endovascular Instruments, Inc. Method for performing a partial atherectomy
US5934284A (en) 1989-08-18 1999-08-10 Endovascular Instruments, Inc Method for increasing blood flow in vessels
DE69023652T2 (de) 1989-08-18 1996-10-31 Evi Corp Katheter zur atherotomie.
US5071424A (en) 1989-08-18 1991-12-10 Evi Corporation Catheter atherotome
US5156610A (en) 1989-08-18 1992-10-20 Evi Corporation Catheter atherotome
JP2984056B2 (ja) 1989-09-08 1999-11-29 ボストン サイエンティフィック コーポレイション 生理学的低圧力血管形成術
US5109859A (en) 1989-10-04 1992-05-05 Beth Israel Hospital Association Ultrasound guided laser angioplasty
US5344395A (en) 1989-11-13 1994-09-06 Scimed Life Systems, Inc. Apparatus for intravascular cavitation or delivery of low frequency mechanical energy
US5290306A (en) 1989-11-29 1994-03-01 Cordis Corporation Puncture resistant balloon catheter
US5074871A (en) 1989-12-07 1991-12-24 Evi Corporation Catheter atherotome
US5178625A (en) 1989-12-07 1993-01-12 Evi Corporation Catheter atherotome
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5158564A (en) 1990-02-14 1992-10-27 Angiomed Ag Atherectomy apparatus
US5084006A (en) 1990-03-30 1992-01-28 Alza Corporation Iontopheretic delivery device
US5238004A (en) 1990-04-10 1993-08-24 Boston Scientific Corporation High elongation linear elastic guidewire
US5098429A (en) 1990-04-17 1992-03-24 Mmtc, Inc. Angioplastic technique employing an inductively-heated ferrite material
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5190540A (en) 1990-06-08 1993-03-02 Cardiovascular & Interventional Research Consultants, Inc. Thermal balloon angioplasty
DE69110467T2 (de) 1990-06-15 1996-02-01 Cortrak Medical Inc Vorrichtung zur abgabe von medikamenten.
US5053033A (en) 1990-10-10 1991-10-01 Boston Advanced Technologies, Inc. Inhibition of restenosis by ultraviolet radiation
US5304171A (en) 1990-10-18 1994-04-19 Gregory Kenton W Catheter devices and methods for delivering
US5139496A (en) 1990-12-20 1992-08-18 Hed Aharon Z Ultrasonic freeze ablation catheters and probes
US6524274B1 (en) 1990-12-28 2003-02-25 Scimed Life Systems, Inc. Triggered release hydrogel drug delivery system
US5170802A (en) 1991-01-07 1992-12-15 Medtronic, Inc. Implantable electrode for location within a blood vessel
US5997497A (en) 1991-01-11 1999-12-07 Advanced Cardiovascular Systems Ultrasound catheter having integrated drug delivery system and methods of using same
US5957882A (en) 1991-01-11 1999-09-28 Advanced Cardiovascular Systems, Inc. Ultrasound devices for ablating and removing obstructive matter from anatomical passageways and blood vessels
US5312328A (en) 1991-01-11 1994-05-17 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5405318A (en) 1992-05-05 1995-04-11 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5368557A (en) 1991-01-11 1994-11-29 Baxter International Inc. Ultrasonic ablation catheter device having multiple ultrasound transmission members
US5324255A (en) 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5447509A (en) 1991-01-11 1995-09-05 Baxter International Inc. Ultrasound catheter system having modulated output with feedback control
US5380274A (en) 1991-01-11 1995-01-10 Baxter International Inc. Ultrasound transmission member having improved longitudinal transmission properties
US5304115A (en) 1991-01-11 1994-04-19 Baxter International Inc. Ultrasonic angioplasty device incorporating improved transmission member and ablation probe
US5368558A (en) 1991-01-11 1994-11-29 Baxter International Inc. Ultrasonic ablation catheter device having endoscopic component and method of using same
US5916192A (en) 1991-01-11 1999-06-29 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty-atherectomy catheter and method of use
US5267954A (en) 1991-01-11 1993-12-07 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5542917A (en) 1991-01-11 1996-08-06 Baxter International, Inc. Ultrasound delivery catheters incorporating improved distal tip construction
AU660444B2 (en) 1991-02-15 1995-06-29 Ingemar H. Lundquist Torquable catheter and method
US5234407A (en) 1991-03-06 1993-08-10 Baxter International Inc. Method and device for exchanging cardiovascular guide catheter while a previously inserted angioplasty guide wire remains in place
US5454788A (en) 1991-04-24 1995-10-03 Baxter International Inc. Exchangeable integrated-wire balloon catheter
US5251634A (en) 1991-05-03 1993-10-12 Cyberonics, Inc. Helical nerve electrode
US6309379B1 (en) 1991-05-23 2001-10-30 Lloyd K. Willard Sheath for selective delivery of multiple intravascular devices and methods of use thereof
US5383917A (en) 1991-07-05 1995-01-24 Jawahar M. Desai Device and method for multi-phase radio-frequency ablation
US5270654A (en) 1991-07-05 1993-12-14 Feinberg David A Ultra-fast multi-section MRI using gradient and spin echo (grase) imaging
JPH0596012A (ja) 1991-10-07 1993-04-20 Olympus Optical Co Ltd 温熱治療装置
US5697909A (en) 1992-01-07 1997-12-16 Arthrocare Corporation Methods and apparatus for surgical cutting
DE69224911T2 (de) 1991-11-04 1998-12-03 Baxter Int Ultraschallgerät zur ablation mit kanal für führungsdraht
JP3530528B2 (ja) 1991-11-08 2004-05-24 ボストン サイエンティフィック リミテッド 絶縁された温度感知素子を有する切除電極
US5383874A (en) 1991-11-08 1995-01-24 Ep Technologies, Inc. Systems for identifying catheters and monitoring their use
US5906614A (en) 1991-11-08 1999-05-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods using predicted temperature for monitoring and control
US5601526A (en) 1991-12-20 1997-02-11 Technomed Medical Systems Ultrasound therapy apparatus delivering ultrasound waves having thermal and cavitation effects
US5498261A (en) 1991-12-20 1996-03-12 Advanced Cardiovascular Systems, Inc. Thermal angioplasty system
US5301683A (en) 1991-12-23 1994-04-12 Durkan John A Diagnosing carpal tunnel syndrome
US5522873A (en) 1991-12-26 1996-06-04 Webster Laboratories, Inc. Catheter having electrode with annular recess and method of using same
US5681282A (en) 1992-01-07 1997-10-28 Arthrocare Corporation Methods and apparatus for ablation of luminal tissues
US5419767A (en) 1992-01-07 1995-05-30 Thapliyal And Eggers Partners Methods and apparatus for advancing catheters through severely occluded body lumens
US6179824B1 (en) 1993-05-10 2001-01-30 Arthrocare Corporation System and methods for electrosurgical restenosis of body lumens
US5242441A (en) 1992-02-24 1993-09-07 Boaz Avitall Deflectable catheter with rotatable tip electrode
US5263493A (en) 1992-02-24 1993-11-23 Boaz Avitall Deflectable loop electrode array mapping and ablation catheter for cardiac chambers
US5330518A (en) 1992-03-06 1994-07-19 Urologix, Inc. Method for treating interstitial tissue associated with microwave thermal therapy
US5306250A (en) 1992-04-02 1994-04-26 Indiana University Foundation Method and apparatus for intravascular drug delivery
US5573533A (en) 1992-04-10 1996-11-12 Medtronic Cardiorhythm Method and system for radiofrequency ablation of cardiac tissue
US5540681A (en) 1992-04-10 1996-07-30 Medtronic Cardiorhythm Method and system for radiofrequency ablation of tissue
US5314466A (en) 1992-04-13 1994-05-24 Ep Technologies, Inc. Articulated unidirectional microwave antenna systems for cardiac ablation
US5300068A (en) 1992-04-21 1994-04-05 St. Jude Medical, Inc. Electrosurgical apparatus
US5810810A (en) 1992-04-23 1998-09-22 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
US6063085A (en) 1992-04-23 2000-05-16 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
JPH07506991A (ja) 1992-04-23 1995-08-03 シメッド　ライフ　システムズ　インコーポレイテッド 血管穿刺を密封するための装置及び方法
USRE40863E1 (en) 1992-04-23 2009-07-21 Boston Scientific Scimed, Inc. Apparatus and method for sealing vascular punctures
US5277201A (en) 1992-05-01 1994-01-11 Vesta Medical, Inc. Endometrial ablation apparatus and method
US5443470A (en) 1992-05-01 1995-08-22 Vesta Medical, Inc. Method and apparatus for endometrial ablation
US5295484A (en) 1992-05-19 1994-03-22 Arizona Board Of Regents For And On Behalf Of The University Of Arizona Apparatus and method for intra-cardiac ablation of arrhythmias
US5255679A (en) 1992-06-02 1993-10-26 Cardiac Pathways Corporation Endocardial catheter for mapping and/or ablation with an expandable basket structure having means for providing selective reinforcement and pressure sensing mechanism for use therewith, and method
US5478351A (en) 1992-06-24 1995-12-26 Microsurge, Inc. Endoscopic surgical tool with handle and detachable tool assembly
JP2726756B2 (ja) 1992-06-26 1998-03-11 シュナイダー・（ユーエスエイ）・インコーポレーテッド 膨張可能な金網先端を有するカテーテル
US5382228A (en) 1992-07-09 1995-01-17 Baxter International Inc. Method and device for connecting ultrasound transmission member (S) to an ultrasound generating device
US5365172A (en) 1992-08-07 1994-11-15 Brigham And Women's Hospital Methods and apparatus for MRI
US5297564A (en) 1992-08-27 1994-03-29 Love Jack W Catheter technique for creation of an aortico-pulmonary shunt
US5401272A (en) 1992-09-25 1995-03-28 Envision Surgical Systems, Inc. Multimodality probe with extendable bipolar electrodes
US5333614A (en) 1992-09-28 1994-08-02 Feiring Andrew J Measurement of absolute vascular flow
US5471982A (en) 1992-09-29 1995-12-05 Ep Technologies, Inc. Cardiac mapping and ablation systems
US6086581A (en) 1992-09-29 2000-07-11 Ep Technologies, Inc. Large surface cardiac ablation catheter that assumes a low profile during introduction into the heart
WO1994007446A1 (en) 1992-10-05 1994-04-14 Boston Scientific Corporation Device and method for heating tissue
CA2107741C (en) 1992-10-07 2000-06-27 Peter T. Keith Ablation devices and methods of use
US5687737A (en) 1992-10-09 1997-11-18 Washington University Computerized three-dimensional cardiac mapping with interactive visual displays
US6398782B1 (en) 1992-10-13 2002-06-04 Edwards Lifesciences Corporation Bipolar vascular sealing apparatus and methods
US5432876C1 (en) 1992-10-19 2002-05-21 Minnesota Mining & Mfg Illumination devices and optical fibres for use therein
US5634901A (en) 1992-11-02 1997-06-03 Localmed, Inc. Method of using a catheter sleeve
US5643297A (en) 1992-11-09 1997-07-01 Endovascular Instruments, Inc. Intra-artery obstruction clearing apparatus and methods
US5571122A (en) 1992-11-09 1996-11-05 Endovascular Instruments, Inc. Unitary removal of plaque
US5807306A (en) 1992-11-09 1998-09-15 Cortrak Medical, Inc. Polymer matrix drug delivery apparatus
WO1994010922A1 (en) 1992-11-13 1994-05-26 Ep Technologies, Inc. Cardial ablation systems using temperature monitoring
DE4338758C2 (de) 1992-11-13 2001-08-09 Scimed Life Systems Inc Katheteranordnung
US6068653A (en) 1992-11-13 2000-05-30 Scimed Life Systems, Inc. Electrophysiology catheter device
US5676693A (en) 1992-11-13 1997-10-14 Scimed Life Systems, Inc. Electrophysiology device
US6923805B1 (en) 1992-11-13 2005-08-02 Scimed Life Systems, Inc. Electrophysiology energy treatment devices and methods of use
US5545161A (en) 1992-12-01 1996-08-13 Cardiac Pathways Corporation Catheter for RF ablation having cooled electrode with electrically insulated sleeve
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5706809A (en) 1993-01-29 1998-01-13 Cardima, Inc. Method and system for using multiple intravascular sensing devices to detect electrical activity
ATE178218T1 (de) 1993-02-05 1999-04-15 Joe W And Dorothy Dorsett Brow Ultraschallballonkatheter für angioplastik
US5512051A (en) 1993-02-16 1996-04-30 Boston Scientific Corporation Slip-layered catheter balloon
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US6346074B1 (en) 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
US6161543A (en) 1993-02-22 2000-12-19 Epicor, Inc. Methods of epicardial ablation for creating a lesion around the pulmonary veins
US5403311A (en) 1993-03-29 1995-04-04 Boston Scientific Corporation Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue
US6915806B2 (en) 1993-05-10 2005-07-12 Arthrocare Corporation Method for harvesting graft vessel
US5693082A (en) 1993-05-14 1997-12-02 Fidus Medical Technology Corporation Tunable microwave ablation catheter system and method
US5405346A (en) 1993-05-14 1995-04-11 Fidus Medical Technology Corporation Tunable microwave ablation catheter
US5364392A (en) 1993-05-14 1994-11-15 Fidus Medical Technology Corporation Microwave ablation catheter system with impedance matching tuner and method
US5630837A (en) 1993-07-01 1997-05-20 Boston Scientific Corporation Acoustic ablation
US5860974A (en) 1993-07-01 1999-01-19 Boston Scientific Corporation Heart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft
WO1995001751A1 (en) 1993-07-01 1995-01-19 Boston Scientific Corporation Imaging, electrical potential sensing, and ablation catheters
US5584831A (en) 1993-07-09 1996-12-17 September 28, Inc. Spinal fixation device and method
US5409000A (en) 1993-09-14 1995-04-25 Cardiac Pathways Corporation Endocardial mapping and ablation system utilizing separately controlled steerable ablation catheter with ultrasonic imaging capabilities and method
US5843124A (en) 1993-09-28 1998-12-01 Hemodynamics, Inc. Surface opening adhesive sealer
US5427118A (en) 1993-10-04 1995-06-27 Baxter International Inc. Ultrasonic guidewire
US5417672A (en) 1993-10-04 1995-05-23 Baxter International Inc. Connector for coupling an ultrasound transducer to an ultrasound catheter
US5496312A (en) 1993-10-07 1996-03-05 Valleylab Inc. Impedance and temperature generator control
WO1995010225A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Multiple electrode element for mapping and ablating
US5840076A (en) 1996-04-12 1998-11-24 Ep Technologies, Inc. Tissue heating and ablation systems and methods using electrode structures with distally oriented porous regions
US5991650A (en) 1993-10-15 1999-11-23 Ep Technologies, Inc. Surface coatings for catheters, direct contacting diagnostic and therapeutic devices
US5797903A (en) 1996-04-12 1998-08-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods using porous electrode structures with electrically conductive surfaces
US5599346A (en) 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment system
JP3400835B2 (ja) 1993-12-20 2003-04-28 テルモ株式会社 副伝導路検出装置
US5441498A (en) 1994-02-16 1995-08-15 Envision Surgical Systems, Inc. Method of using a multimodality probe with extendable bipolar electrodes
US5588962A (en) 1994-03-29 1996-12-31 Boston Scientific Corporation Drug treatment of diseased sites deep within the body
US5505201A (en) 1994-04-20 1996-04-09 Case Western Reserve University Implantable helical spiral cuff electrode
US5451207A (en) 1994-04-25 1995-09-19 The Regents Of The University Of California Method of coronary plaque removal with bypass and perfusion
US5715819A (en) 1994-05-26 1998-02-10 The Carolinas Heart Institute Microwave tomographic spectroscopy system and method
US5573531A (en) 1994-06-20 1996-11-12 Gregory; Kenton W. Fluid core laser angioscope
US6056744A (en) 1994-06-24 2000-05-02 Conway Stuart Medical, Inc. Sphincter treatment apparatus
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
US5505730A (en) 1994-06-24 1996-04-09 Stuart D. Edwards Thin layer ablation apparatus
CA2194061C (en) 1994-06-27 2006-04-11 David K. Swanson Systems and methods for sensing temperature within the body
CA2194071C (en) 1994-06-27 2005-12-13 Roger A. Stern Non-linear control systems and methods for heating and ablating body tissue
US5735846A (en) 1994-06-27 1998-04-07 Ep Technologies, Inc. Systems and methods for ablating body tissue using predicted maximum tissue temperature
ES2214493T3 (es) 1994-06-27 2004-09-16 Boston Scientific Limited Un sistema de regulacion de ablacion del tejido usando los sensores de la temperatura.
AU2970495A (en) 1994-07-19 1996-02-16 Hologram Technology International, Inc. Image recording medium and method of making same
US5810802A (en) 1994-08-08 1998-09-22 E.P. Technologies, Inc. Systems and methods for controlling tissue ablation using multiple temperature sensing elements
US5967976A (en) 1994-08-19 1999-10-19 Novoste Corporation Apparatus and methods for procedures related to the electrophysiology of the heart
US5531520A (en) 1994-09-01 1996-07-02 Massachusetts Institute Of Technology System and method of registration of three-dimensional data sets including anatomical body data
US8025661B2 (en) 1994-09-09 2011-09-27 Cardiofocus, Inc. Coaxial catheter instruments for ablation with radiant energy
US6572609B1 (en) 1999-07-14 2003-06-03 Cardiofocus, Inc. Phototherapeutic waveguide apparatus
US5647847A (en) 1994-09-16 1997-07-15 Scimed Life Systems, Inc. Balloon catheter with improved pressure source
US5876336A (en) 1994-10-11 1999-03-02 Ep Technologies, Inc. Systems and methods for guiding movable electrode elements within multiple-electrode structure
US5810742A (en) 1994-10-24 1998-09-22 Transcan Research & Development Co., Ltd. Tissue characterization based on impedance images and on impedance measurements
US5571151A (en) 1994-10-25 1996-11-05 Gregory; Kenton W. Method for contemporaneous application of laser energy and localized pharmacologic therapy
US5817144A (en) 1994-10-25 1998-10-06 Latis, Inc. Method for contemporaneous application OF laser energy and localized pharmacologic therapy
US6689086B1 (en) 1994-10-27 2004-02-10 Advanced Cardiovascular Systems, Inc. Method of using a catheter for delivery of ultrasonic energy and medicament
US5643255A (en) 1994-12-12 1997-07-01 Hicor, Inc. Steerable catheter with rotatable tip electrode and method of use
US5665062A (en) 1995-01-23 1997-09-09 Houser; Russell A. Atherectomy catheter and RF cutting method
US5776174A (en) 1995-01-30 1998-07-07 Illumenex Corporation Stabilization of vascular lesions by ultraviolet radiation
FR2729845B1 (fr) 1995-02-01 1997-07-25 Centre Nat Rech Scient Catheter d'imagerie echographique endocavitaire
US6409722B1 (en) 1998-07-07 2002-06-25 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US5695504A (en) 1995-02-24 1997-12-09 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US5904697A (en) 1995-02-24 1999-05-18 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US6110187A (en) 1995-02-24 2000-08-29 Heartport, Inc. Device and method for minimizing heart displacements during a beating heart surgical procedure
JP4408958B2 (ja) 1995-02-28 2010-02-03 ボストン サイエンティフィック コーポレーション 医療器具
US5797849A (en) 1995-03-28 1998-08-25 Sonometrics Corporation Method for carrying out a medical procedure using a three-dimensional tracking and imaging system
US6425912B1 (en) 1995-05-05 2002-07-30 Thermage, Inc. Method and apparatus for modifying skin surface and soft tissue structure
US5755753A (en) 1995-05-05 1998-05-26 Thermage, Inc. Method for controlled contraction of collagen tissue
US6430446B1 (en) 1995-05-05 2002-08-06 Thermage, Inc. Apparatus for tissue remodeling
US6241753B1 (en) 1995-05-05 2001-06-05 Thermage, Inc. Method for scar collagen formation and contraction
US5660836A (en) 1995-05-05 1997-08-26 Knowlton; Edward W. Method and apparatus for controlled contraction of collagen tissue
US6251104B1 (en) 1995-05-10 2001-06-26 Eclipse Surgical Technologies, Inc. Guiding catheter system for ablating heart tissue
US5782760A (en) 1995-05-23 1998-07-21 Cardima, Inc. Over-the-wire EP catheter
US5666964A (en) 1995-06-06 1997-09-16 Meilus; Algis A. Muscle treatment devices
US6190379B1 (en) 1995-06-06 2001-02-20 Sun Star Technology, Inc. Hot tip catheter
US6837888B2 (en) 1995-06-07 2005-01-04 Arthrocare Corporation Electrosurgical probe with movable return electrode and methods related thereto
US6632193B1 (en) 1995-06-07 2003-10-14 Arthrocare Corporation Systems and methods for electrosurgical tissue treatment
US6293943B1 (en) 1995-06-07 2001-09-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods which predict maximum tissue temperature
US5741248A (en) 1995-06-07 1998-04-21 Temple University-Of The Commonwealth System Of Higher Education Fluorochemical liquid augmented cryosurgery
US6293942B1 (en) 1995-06-23 2001-09-25 Gyrus Medical Limited Electrosurgical generator method
CN1095641C (zh) 1995-06-23 2002-12-11 盖拉斯医疗有限公司 电手术器械
US5702433A (en) 1995-06-27 1997-12-30 Arrow International Investment Corp. Kink-resistant steerable catheter assembly for microwave ablation
US8241217B2 (en) 1995-06-29 2012-08-14 Teratech Corporation Portable ultrasound imaging data
EP0835075A4 (en) 1995-06-30 1999-06-23 Boston Scient Corp CATHETER FOR ULTRASONIC IMAGING, WITH A CUTTING ELEMENT
US5693029A (en) 1995-07-10 1997-12-02 World Medical Manufacturing Corporation Pro-cell intra-cavity therapeutic agent delivery device
US5865801A (en) 1995-07-18 1999-02-02 Houser; Russell A. Multiple compartmented balloon catheter with external pressure sensing
US5800484A (en) 1995-08-15 1998-09-01 Rita Medical Systems, Inc. Multiple antenna ablation apparatus with expanded electrodes
US5672174A (en) 1995-08-15 1997-09-30 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US6763261B2 (en) 1995-09-20 2004-07-13 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US6090618A (en) 1996-10-07 2000-07-18 Arch Development Corporation DNA constructs and viral vectors comprising a smooth muscle promoter
ATE275880T1 (de) 1995-10-13 2004-10-15 Transvascular Inc Vorrichtung zur umgehung von arteriellen verengungen und/oder zur ausführung anderer transvaskularer eingriffe
DE69638011D1 (de) 1995-10-13 2009-10-08 Medtronic Vascular Inc Ngriff
US5846245A (en) 1995-10-20 1998-12-08 New York University Bone-adjusting device
US5817092A (en) 1995-11-09 1998-10-06 Radio Therapeutics Corporation Apparatus, system and method for delivering radio frequency energy to a treatment site
US5833593A (en) 1995-11-09 1998-11-10 United States Surgical Corporation Flexible source wire for localized internal irradiation of tissue
US5906623A (en) 1995-12-11 1999-05-25 Boston Scientific Corporation Lithotripsy system
US6350276B1 (en) 1996-01-05 2002-02-26 Thermage, Inc. Tissue remodeling apparatus containing cooling fluid
US5836874A (en) 1996-04-08 1998-11-17 Ep Technologies, Inc. Multi-function electrode structures for electrically analyzing and heating body tissue
WO1997025918A1 (en) 1996-01-19 1997-07-24 Ep Technologies, Inc. Electrode structures formed from flexible, porous, or woven materials
US5868736A (en) 1996-04-12 1999-02-09 Ep Technologies, Inc. Systems and methods to control tissue heating or ablation with porous electrode structures
US5846239A (en) 1996-04-12 1998-12-08 Ep Technologies, Inc. Tissue heating and ablation systems and methods using segmented porous electrode structures
US5830213A (en) 1996-04-12 1998-11-03 Ep Technologies, Inc. Systems for heating and ablating tissue using multifunctional electrode structures
US5871483A (en) 1996-01-19 1999-02-16 Ep Technologies, Inc. Folding electrode structures
US5961513A (en) 1996-01-19 1999-10-05 Ep Technologies, Inc. Tissue heating and ablation systems and methods using porous electrode structures
US5925038A (en) 1996-01-19 1999-07-20 Ep Technologies, Inc. Expandable-collapsible electrode structures for capacitive coupling to tissue
US5891135A (en) 1996-01-19 1999-04-06 Ep Technologies, Inc. Stem elements for securing tubing and electrical wires to expandable-collapsible electrode structures
US6475213B1 (en) 1996-01-19 2002-11-05 Ep Technologies, Inc. Method of ablating body tissue
US6071278A (en) 1996-02-28 2000-06-06 Ep Technologies, Inc. Tissue heating and ablation systems and methods using porous electrode structures with specified electrical resistivities
US5879348A (en) 1996-04-12 1999-03-09 Ep Technologies, Inc. Electrode structures formed from flexible, porous, or woven materials
US5853411A (en) 1996-01-19 1998-12-29 Ep Technologies, Inc. Enhanced electrical connections for electrode structures
US5846238A (en) 1996-01-19 1998-12-08 Ep Technologies, Inc. Expandable-collapsible electrode structures with distal end steering or manipulation
US5891136A (en) 1996-01-19 1999-04-06 Ep Technologies, Inc. Expandable-collapsible mesh electrode structures
CA2244066A1 (en) 1996-02-02 1997-08-07 Transvascular, Inc. A device, system and method for interstitial transvascular intervention
US6436056B1 (en) 1996-02-28 2002-08-20 Boston Scientific Corporation Polymeric implements for torque transmission
US6033398A (en) 1996-03-05 2000-03-07 Vnus Medical Technologies, Inc. Method and apparatus for treating venous insufficiency using directionally applied energy
US6139527A (en) 1996-03-05 2000-10-31 Vnus Medical Technologies, Inc. Method and apparatus for treating hemorrhoids
US6036687A (en) 1996-03-05 2000-03-14 Vnus Medical Technologies, Inc. Method and apparatus for treating venous insufficiency
US6152899A (en) 1996-03-05 2000-11-28 Vnus Medical Technologies, Inc. Expandable catheter having improved electrode design, and method for applying energy
US6033397A (en) 1996-03-05 2000-03-07 Vnus Medical Technologies, Inc. Method and apparatus for treating esophageal varices
US5843016A (en) 1996-03-18 1998-12-01 Physion S.R.L. Electromotive drug administration for treatment of acute urinary outflow obstruction
US5690681A (en) 1996-03-29 1997-11-25 Purdue Research Foundation Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation
US5769880A (en) 1996-04-12 1998-06-23 Novacept Moisture transport system for contact electrocoagulation
US7604633B2 (en) 1996-04-12 2009-10-20 Cytyc Corporation Moisture transport system for contact electrocoagulation
US6813520B2 (en) 1996-04-12 2004-11-02 Novacept Method for ablating and/or coagulating tissue using moisture transport
US6673040B1 (en) 1996-04-16 2004-01-06 Cardeon Corporation System and methods for catheter procedures with circulatory support in high risk patients
US5904709A (en) 1996-04-17 1999-05-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Microwave treatment for cardiac arrhythmias
US6022309A (en) 1996-04-24 2000-02-08 The Regents Of The University Of California Opto-acoustic thrombolysis
US20020045890A1 (en) 1996-04-24 2002-04-18 The Regents Of The University O F California Opto-acoustic thrombolysis
US6898454B2 (en) 1996-04-25 2005-05-24 The Johns Hopkins University Systems and methods for evaluating the urethra and the periurethral tissues
US6549800B1 (en) 1996-04-25 2003-04-15 Johns Hopkins Unversity School Of Medicine Methods for in vivo magnetic resonance imaging
AUPN957296A0 (en) 1996-04-30 1996-05-23 Cardiac Crc Nominees Pty Limited A system for simultaneous unipolar multi-electrode ablation
US7022105B1 (en) 1996-05-06 2006-04-04 Novasys Medical Inc. Treatment of tissue in sphincters, sinuses and orifices
US6066139A (en) 1996-05-14 2000-05-23 Sherwood Services Ag Apparatus and method for sterilization and embolization
GB9612993D0 (en) 1996-06-20 1996-08-21 Gyrus Medical Ltd Electrosurgical instrument
US5882346A (en) 1996-07-15 1999-03-16 Cardiac Pathways Corporation Shapable catheter using exchangeable core and method of use
US5662671A (en) 1996-07-17 1997-09-02 Embol-X, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US5832228A (en) 1996-07-30 1998-11-03 Itt Industries, Inc. System and method for providing multi-level security in computer devices utilized with non-secure networks
US5755682A (en) 1996-08-13 1998-05-26 Heartstent Corporation Method and apparatus for performing coronary artery bypass surgery
US6684098B2 (en) 1996-08-16 2004-01-27 Brigham And Women's Hospital, Inc. Versatile stereotactic device and methods of use
US7203537B2 (en) 1996-08-19 2007-04-10 Mr3 Medical, Llc System and method for breaking reentry circuits by cooling cardiac tissue
US5800494A (en) 1996-08-20 1998-09-01 Fidus Medical Technology Corporation Microwave ablation catheters having antennas with distal fire capabilities
US6123679A (en) 1996-08-29 2000-09-26 Lafaut; Jean-Pierre Method for extracorporeal shock wave lithotripsy by applying an acoustic shock wave followed by a limited oscillating acoustic pressure wave train
US6451044B1 (en) 1996-09-20 2002-09-17 Board Of Regents, The University Of Texas System Method and apparatus for heating inflammed tissue
US5906636A (en) 1996-09-20 1999-05-25 Texas Heart Institute Heat treatment of inflamed tissue
US7603166B2 (en) 1996-09-20 2009-10-13 Board Of Regents University Of Texas System Method and apparatus for detection of vulnerable atherosclerotic plaque
US5954740A (en) 1996-09-23 1999-09-21 Boston Scientific Corporation Catheter balloon having raised radial segments
US5957941A (en) 1996-09-27 1999-09-28 Boston Scientific Corporation Catheter system and drive assembly thereof
US5971975A (en) 1996-10-09 1999-10-26 Target Therapeutics, Inc. Guide catheter with enhanced guidewire tracking
US6464697B1 (en) 1998-02-19 2002-10-15 Curon Medical, Inc. Stomach and adjoining tissue regions in the esophagus
US5931834A (en) 1996-10-15 1999-08-03 Eclipse Surgical Technologies, Inc. Method for non-synchronous laser-assisted myocardial revascularization
US5785702A (en) 1996-10-15 1998-07-28 Eclipse Surgical Technologies, Inc. Method for non-synchronous laser-assisted transmyocardial revascularization
US5741249A (en) 1996-10-16 1998-04-21 Fidus Medical Technology Corporation Anchoring tip assembly for microwave ablation catheter
US5810803A (en) 1996-10-16 1998-09-22 Fidus Medical Technology Corporation Conformal positioning assembly for microwave ablation catheter
US6237605B1 (en) 1996-10-22 2001-05-29 Epicor, Inc. Methods of epicardial ablation
US5848969A (en) 1996-10-28 1998-12-15 Ep Technologies, Inc. Systems and methods for visualizing interior tissue regions using expandable imaging structures
US5904651A (en) 1996-10-28 1999-05-18 Ep Technologies, Inc. Systems and methods for visualizing tissue during diagnostic or therapeutic procedures
US5827268A (en) 1996-10-30 1998-10-27 Hearten Medical, Inc. Device for the treatment of patent ductus arteriosus and method of using the device
US6091995A (en) 1996-11-08 2000-07-18 Surx, Inc. Devices, methods, and systems for shrinking tissues
US6081749A (en) 1997-08-13 2000-06-27 Surx, Inc. Noninvasive devices, methods, and systems for shrinking of tissues
US5875782A (en) 1996-11-14 1999-03-02 Cardiothoracic Systems, Inc. Methods and devices for minimally invasive coronary artery revascularization on a beating heart without cardiopulmonary bypass
EP0981393B1 (en) 1996-11-21 2008-07-09 Boston Scientific Limited Device for mucosal ablation using light
US6159187A (en) 1996-12-06 2000-12-12 Target Therapeutics, Inc. Reinforced catheter with a formable distal tip
CA2225521C (en) 1996-12-27 2004-04-06 Eclipse Surgical Technologies, Inc. Laser assisted drug delivery apparatus
US5999678A (en) 1996-12-27 1999-12-07 Eclipse Surgical Technologies, Inc. Laser delivery means adapted for drug delivery
US5775338A (en) 1997-01-10 1998-07-07 Scimed Life Systems, Inc. Heated perfusion balloon for reduction of restenosis
US8329179B2 (en) 1997-01-28 2012-12-11 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
US7452538B2 (en) 1997-01-28 2008-11-18 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
EP1862548A1 (en) 1997-01-28 2007-12-05 Human Genome Sciences, Inc. Death domain containing receptor 4 (DR4 : death receptor 4), member of the TNF-receptor superfamily and binding to trail (APO2-L)
JP2001512334A (ja) 1997-02-12 2001-08-21 プロリフィックス メディカル，インコーポレイテッド ステントから物質を除去する装置
US5989284A (en) 1997-02-18 1999-11-23 Hearten Medical, Inc. Method and device for soft tissue modification
US6120516A (en) 1997-02-28 2000-09-19 Lumend, Inc. Method for treating vascular occlusion
US5868735A (en) 1997-03-06 1999-02-09 Scimed Life Systems, Inc. Cryoplasty device and method
US7220257B1 (en) 2000-07-25 2007-05-22 Scimed Life Systems, Inc. Cryotreatment device and method
US5904667A (en) 1997-03-17 1999-05-18 C.R. Bard, Inc. Rotatable control mechanism for steerable catheter
WO1998041157A1 (en) 1997-03-17 1998-09-24 Boris Rubinsky Freezing method for controlled removal of fatty tissue by liposuction
US7425212B1 (en) 1998-06-10 2008-09-16 Asthmatx, Inc. Devices for modification of airways by transfer of energy
US6488673B1 (en) 1997-04-07 2002-12-03 Broncus Technologies, Inc. Method of increasing gas exchange of a lung
US5972026A (en) 1997-04-07 1999-10-26 Broncus Technologies, Inc. Bronchial stenter having diametrically adjustable electrodes
US6524299B1 (en) 1997-04-09 2003-02-25 Target Therapeutics, Inc. Flow-directed catheter
CA2284720C (en) 1997-04-11 2006-09-12 Transvascular, Inc. Methods and apparatus for transmyocardial direct coronary revascularization
US5827203A (en) 1997-04-21 1998-10-27 Nita; Henry Ultrasound system and method for myocardial revascularization
GB9708268D0 (en) 1997-04-24 1997-06-18 Gyrus Medical Ltd An electrosurgical instrument
US6117128A (en) 1997-04-30 2000-09-12 Kenton W. Gregory Energy delivery catheter and method for the use thereof
US6723063B1 (en) 1998-06-29 2004-04-20 Ekos Corporation Sheath for use with an ultrasound element
US6024740A (en) 1997-07-08 2000-02-15 The Regents Of The University Of California Circumferential ablation device assembly
US5989208A (en) 1997-05-16 1999-11-23 Nita; Henry Therapeutic ultrasound system
US6217576B1 (en) 1997-05-19 2001-04-17 Irvine Biomedical Inc. Catheter probe for treating focal atrial fibrillation in pulmonary veins
US5895378A (en) 1997-05-29 1999-04-20 Target Therapeutics, Inc. Flow-directed catheter having multiple tapers and radio-opaque markers
US6152912A (en) 1997-06-10 2000-11-28 Target Therapeutics, Inc. Optimized high performance spiral-wound vascular catheter
US5951539A (en) 1997-06-10 1999-09-14 Target Therpeutics, Inc. Optimized high performance multiple coil spiral-wound vascular catheter
EP0998248A4 (en) 1997-06-13 2001-03-21 Arthrocare Corp ELECTROSURGICAL DEVICES AND METHOD FOR RECANALIZING OCCLUDED BODY LUMES
US6855143B2 (en) 1997-06-13 2005-02-15 Arthrocare Corporation Electrosurgical systems and methods for recanalization of occluded body lumens
WO1998058588A1 (en) 1997-06-23 1998-12-30 Focus Surgery, Inc. Methods and devices for providing acoustic hemostasis
WO1999000060A1 (en) 1997-06-26 1999-01-07 Advanced Coronary Intervention Electrosurgical catheter for resolving obstructions by radio frequency ablation
US6161048A (en) 1997-06-26 2000-12-12 Radionics, Inc. Method and system for neural tissue modification
US6241666B1 (en) 1997-07-03 2001-06-05 Cardiac Pathways Corp. Ablation catheter tip with a buffer layer covering the electrode
US6547788B1 (en) 1997-07-08 2003-04-15 Atrionx, Inc. Medical device with sensor cooperating with expandable member
US6117101A (en) 1997-07-08 2000-09-12 The Regents Of The University Of California Circumferential ablation device assembly
US6652515B1 (en) 1997-07-08 2003-11-25 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6500174B1 (en) 1997-07-08 2002-12-31 Atrionix, Inc. Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member
US6997925B2 (en) 1997-07-08 2006-02-14 Atrionx, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6966908B2 (en) 1997-07-08 2005-11-22 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6869431B2 (en) 1997-07-08 2005-03-22 Atrionix, Inc. Medical device with sensor cooperating with expandable member
US5891138A (en) 1997-08-11 1999-04-06 Irvine Biomedical, Inc. Catheter system having parallel electrodes
ATE326913T1 (de) 1997-08-13 2006-06-15 Solarant Medical Inc Nichtinvasive geräte und systeme zum schrumpfen von geweben
US9023031B2 (en) 1997-08-13 2015-05-05 Verathon Inc. Noninvasive devices, methods, and systems for modifying tissues
US6402719B1 (en) 1997-09-05 2002-06-11 Cordis Webster, Inc. Steerable DMR catheter with infusion tube
US5964757A (en) 1997-09-05 1999-10-12 Cordis Webster, Inc. Steerable direct myocardial revascularization catheter
US6258084B1 (en) 1997-09-11 2001-07-10 Vnus Medical Technologies, Inc. Method for applying energy to biological tissue including the use of tumescent tissue compression
US6401719B1 (en) 1997-09-11 2002-06-11 Vnus Medical Technologies, Inc. Method of ligating hollow anatomical structures
US6200312B1 (en) 1997-09-11 2001-03-13 Vnus Medical Technologies, Inc. Expandable vein ligator catheter having multiple electrode leads
US6179832B1 (en) 1997-09-11 2001-01-30 Vnus Medical Technologies, Inc. Expandable catheter having two sets of electrodes
US5954717A (en) 1997-09-25 1999-09-21 Radiotherapeutics Corporation Method and system for heating solid tissue
US8257725B2 (en) 1997-09-26 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US5891114A (en) 1997-09-30 1999-04-06 Target Therapeutics, Inc. Soft-tip high performance braided catheter
US6238389B1 (en) 1997-09-30 2001-05-29 Boston Scientific Corporation Deflectable interstitial ablation device
US6007514A (en) 1997-09-30 1999-12-28 Nita; Henry Ultrasound system with pathfinding guidewire
CA2307021A1 (en) 1997-10-08 1999-04-15 Kaneka Corporation Balloon catheter and method for manufacturing same
US6231516B1 (en) 1997-10-14 2001-05-15 Vacusense, Inc. Endoluminal implant with therapeutic and diagnostic capability
US5935063A (en) 1997-10-29 1999-08-10 Irvine Biomedical, Inc. Electrode catheter system and methods thereof
US6156046A (en) 1997-11-07 2000-12-05 Prolifix Medical, Inc. Methods and systems for treating obstructions in a body lumen
US6120476A (en) 1997-12-01 2000-09-19 Cordis Webster, Inc. Irrigated tip catheter
US5971979A (en) 1997-12-02 1999-10-26 Odyssey Technologies, Inc. Method for cryogenic inhibition of hyperplasia
US6917834B2 (en) * 1997-12-03 2005-07-12 Boston Scientific Scimed, Inc. Devices and methods for creating lesions in endocardial and surrounding tissue to isolate focal arrhythmia substrates
CA2318243A1 (en) 1998-01-12 1999-07-15 Ronald P. Lesser Technique for using brain heat flow management to treat brain disorders
WO1999035988A1 (en) 1998-01-14 1999-07-22 Conway-Stuart Medical, Inc. Electrosurgical device for sphincter treatment
EP1047348A1 (en) 1998-01-14 2000-11-02 Conway-Stuart Medical, Inc. Lectrosurgical apparatus for treating gatroesophageal reflux disease (gerd) and method
EP1051109A4 (en) 1998-01-26 2005-03-09 Scimed Life Systems Inc CATHETER ASSEMBLY COMPRISING AN INDUCTIVE COUPLER OF DISTAL END AND AN INCORPORATED TRANSMISSION LINE
US6517534B1 (en) 1998-02-11 2003-02-11 Cosman Company, Inc. Peri-urethral ablation
US6447505B2 (en) 1998-02-11 2002-09-10 Cosman Company, Inc. Balloon catheter method for intra-urethral radio-frequency urethral enlargement
US6651670B2 (en) 1998-02-13 2003-11-25 Ventrica, Inc. Delivering a conduit into a heart wall to place a coronary vessel in communication with a heart chamber and removing tissue from the vessel or heart wall to facilitate such communication
US7165551B2 (en) 1998-02-19 2007-01-23 Curon Medical, Inc. Apparatus to detect and treat aberrant myoelectric activity
US6258087B1 (en) 1998-02-19 2001-07-10 Curon Medical, Inc. Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions
US6273886B1 (en) 1998-02-19 2001-08-14 Curon Medical, Inc. Integrated tissue heating and cooling apparatus
US6423058B1 (en) * 1998-02-19 2002-07-23 Curon Medical, Inc. Assemblies to visualize and treat sphincters and adjoining tissue regions
CA2321671C (en) 1998-03-02 2009-07-14 Atrionix, Inc. Tissue ablation system and method for forming long linear lesion
CA2320109A1 (en) 1998-03-06 1999-09-10 Curon Medical, Inc. Apparatus to electrosurgically treat esophageal sphincters
US6115626A (en) 1998-03-26 2000-09-05 Scimed Life Systems, Inc. Systems and methods using annotated images for controlling the use of diagnostic or therapeutic instruments in instruments in interior body regions
AU3454999A (en) 1998-03-30 1999-10-18 University Of Virginia Patent Foundation Flow arrest, double balloon technique for occluding aneurysms or blood vessels
US6905494B2 (en) 1998-03-31 2005-06-14 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US6200266B1 (en) 1998-03-31 2001-03-13 Case Western Reserve University Method and apparatus for ultrasound imaging using acoustic impedance reconstruction
US6685732B2 (en) 1998-03-31 2004-02-03 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
US6142991A (en) 1998-03-31 2000-11-07 Galil Medical, Ltd. High resolution cryosurgical method and apparatus
US7001378B2 (en) 1998-03-31 2006-02-21 Innercool Therapies, Inc. Method and device for performing cooling or cryo-therapies, for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
WO1999049908A1 (en) 1998-03-31 1999-10-07 University Of Cincinnati Temperature controlled solute delivery system
US6666874B2 (en) 1998-04-10 2003-12-23 Endicor Medical, Inc. Rotational atherectomy system with serrated cutting tip
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US20020065542A1 (en) 1998-04-22 2002-05-30 Ronald G. Lax Method and apparatus for treating an aneurysm
US6161047A (en) 1998-04-30 2000-12-12 Medtronic Inc. Apparatus and method for expanding a stimulation lead body in situ
US6558378B2 (en) 1998-05-05 2003-05-06 Cardiac Pacemakers, Inc. RF ablation system and method having automatic temperature control
US6050994A (en) 1998-05-05 2000-04-18 Cardiac Pacemakers, Inc. RF ablation apparatus and method using controllable duty cycle with alternate phasing
US6066096A (en) 1998-05-08 2000-05-23 Duke University Imaging probes and catheters for volumetric intraluminal ultrasound imaging and related systems
US6508815B1 (en) 1998-05-08 2003-01-21 Novacept Radio-frequency generator for powering an ablation device
US6022901A (en) 1998-05-13 2000-02-08 Pharmascience Inc. Administration of resveratrol to prevent or treat restenosis following coronary intervention
US7494488B2 (en) 1998-05-28 2009-02-24 Pearl Technology Holdings, Llc Facial tissue strengthening and tightening device and methods
US7198635B2 (en) 2000-10-17 2007-04-03 Asthmatx, Inc. Modification of airways by application of energy
EP1378262A3 (en) 1998-06-12 2004-03-17 Cardiac Pacemakers, Inc. Modified guidewire for left ventricular access lead
US6121775A (en) 1998-06-16 2000-09-19 Beth Israel Deaconess Medical Center, Inc. MRI imaging method and apparatus
WO1999065561A1 (en) 1998-06-19 1999-12-23 Cordis Webster, Inc. Method and apparatus for transvascular treatment of tachycardia and fibrillation
US6322559B1 (en) 1998-07-06 2001-11-27 Vnus Medical Technologies, Inc. Electrode catheter having coil structure
US6394096B1 (en) 1998-07-15 2002-05-28 Corazon Technologies, Inc. Method and apparatus for treatment of cardiovascular tissue mineralization
US9415222B2 (en) 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US5980563A (en) 1998-08-31 1999-11-09 Tu; Lily Chen Ablation apparatus and methods for treating atherosclerosis
US6228109B1 (en) 1998-08-31 2001-05-08 Lily Chen Tu Methods for treating atherosclerosis and vulnerable plaques
US20050080374A1 (en) 1998-09-01 2005-04-14 Brady Esch Method and apparatus for treating acute myocardial infarction with selective hypothermic perfusion
US6251128B1 (en) 1998-09-01 2001-06-26 Fidus Medical Technology Corporation Microwave ablation catheter with loop configuration
US6183468B1 (en) 1998-09-10 2001-02-06 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6123702A (en) 1998-09-10 2000-09-26 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6489307B1 (en) 1998-09-14 2002-12-03 University Of Florida Antisense compositions targeted to β1-adrenoceptor-specific mRNA and methods of use
US7722539B2 (en) 1998-09-18 2010-05-25 University Of Washington Treatment of unwanted tissue by the selective destruction of vasculature providing nutrients to the tissue
US6425867B1 (en) 1998-09-18 2002-07-30 University Of Washington Noise-free real time ultrasonic imaging of a treatment site undergoing high intensity focused ultrasound therapy
US6299379B1 (en) 1998-09-18 2001-10-09 Lewis Hunting Accessories, Mfg., Inc. Reflective trail markers
US6123703A (en) 1998-09-19 2000-09-26 Tu; Lily Chen Ablation catheter and methods for treating tissues
US6319251B1 (en) 1998-09-24 2001-11-20 Hosheng Tu Medical device and methods for treating intravascular restenosis
EP1115328A4 (en) 1998-09-24 2004-11-10 Super Dimension Ltd SYSTEM AND METHOD FOR LOCATING A CATHETER DURING AN ENDOCORPOREAL MEDICAL EXAMINATION
US6036689A (en) 1998-09-24 2000-03-14 Tu; Lily Chen Ablation device for treating atherosclerotic tissues
US20060240070A1 (en) 1998-09-24 2006-10-26 Cromack Keith R Delivery of highly lipophilic agents via medical devices
US8257724B2 (en) 1998-09-24 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US6283935B1 (en) 1998-09-30 2001-09-04 Hearten Medical Ultrasonic device for providing reversible tissue damage to heart muscle
US7137980B2 (en) 1998-10-23 2006-11-21 Sherwood Services Ag Method and system for controlling output of RF medical generator
US6796981B2 (en) 1999-09-30 2004-09-28 Sherwood Services Ag Vessel sealing system
US7901400B2 (en) 1998-10-23 2011-03-08 Covidien Ag Method and system for controlling output of RF medical generator
US6123718A (en) 1998-11-02 2000-09-26 Polymerex Medical Corp. Balloon catheter
US6701176B1 (en) 1998-11-04 2004-03-02 Johns Hopkins University School Of Medicine Magnetic-resonance-guided imaging, electrophysiology, and ablation
US6508803B1 (en) 1998-11-06 2003-01-21 Furukawa Techno Material Co., Ltd. Niti-type medical guide wire and method of producing the same
JP2000140118A (ja) * 1998-11-09 2000-05-23 Olympus Optical Co Ltd 高周波処置具
US6673290B1 (en) 1998-11-12 2004-01-06 Scimed Life Systems, Inc. Electrode structure for heating and ablating tissue and method for making and assembling the same
US6210406B1 (en) 1998-12-03 2001-04-03 Cordis Webster, Inc. Split tip electrode catheter and signal processing RF ablation system
US6129725A (en) 1998-12-04 2000-10-10 Tu; Lily Chen Methods for reduction of restenosis
US6078839A (en) 1998-12-09 2000-06-20 Pacesetter, Inc. Abrasion resistant implantable lead insulation protector
US20070066972A1 (en) 2001-11-29 2007-03-22 Medwaves, Inc. Ablation catheter apparatus with one or more electrodes
WO2000035531A1 (en) 1998-12-14 2000-06-22 Tre Esse Progettazione Biomedica S.R.L. Catheter system for performing intramyocardiac therapeutic treatment
US7066900B2 (en) 1998-12-23 2006-06-27 Life Therapeutics Removal of metabolic components from blood
US6106477A (en) 1998-12-28 2000-08-22 Medtronic, Inc. Chronically implantable blood vessel cuff with sensor
US6296619B1 (en) 1998-12-30 2001-10-02 Pharmasonics, Inc. Therapeutic ultrasonic catheter for delivering a uniform energy dose
US6102908A (en) 1999-01-04 2000-08-15 Tu; Lily Chen Rotatable apparatus having ablation capabilities
WO2000040955A1 (en) 1999-01-05 2000-07-13 Kaiku Limited Impedance measurements of bodily matter
US6206831B1 (en) 1999-01-06 2001-03-27 Scimed Life Systems, Inc. Ultrasound-guided ablation catheter and methods of use
US6228076B1 (en) 1999-01-09 2001-05-08 Intraluminal Therapeutics, Inc. System and method for controlling tissue ablation
US7122019B1 (en) 2000-11-28 2006-10-17 Flowmedica Inc. Intra-aortic renal drug delivery catheter
US6749598B1 (en) 1999-01-11 2004-06-15 Flowmedica, Inc. Apparatus and methods for treating congestive heart disease
US7329236B2 (en) 1999-01-11 2008-02-12 Flowmedica, Inc. Intra-aortic renal drug delivery catheter
US7481803B2 (en) 2000-11-28 2009-01-27 Flowmedica, Inc. Intra-aortic renal drug delivery catheter
US7780628B1 (en) 1999-01-11 2010-08-24 Angiodynamics, Inc. Apparatus and methods for treating congestive heart disease
US6695830B2 (en) 1999-01-15 2004-02-24 Scimed Life Systems, Inc. Method for delivering medication into an arterial wall for prevention of restenosis
US6191862B1 (en) 1999-01-20 2001-02-20 Lightlab Imaging, Llc Methods and apparatus for high speed longitudinal scanning in imaging systems
US6423057B1 (en) 1999-01-25 2002-07-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Method and apparatus for monitoring and controlling tissue temperature and lesion formation in radio-frequency ablation procedures
US6592526B1 (en) 1999-01-25 2003-07-15 Jay Alan Lenker Resolution ultrasound devices for imaging and treatment of body lumens
US6113615A (en) 1999-02-03 2000-09-05 Scimed Life Systems, Inc. Atherectomy burr including a bias wire
US6236883B1 (en) 1999-02-03 2001-05-22 The Trustees Of Columbia University In The City Of New York Methods and systems for localizing reentrant circuits from electrogram features
US6203537B1 (en) 1999-02-04 2001-03-20 Sorin Adrian Laser-driven acoustic ablation catheter
JP4350310B2 (ja) 1999-02-10 2009-10-21 スワミナサン ジャヤラマン 寒冷療法用のバルーンカテーテル
US6855123B2 (en) 2002-08-02 2005-02-15 Flow Cardia, Inc. Therapeutic ultrasound system
EP1154727B1 (en) 1999-02-19 2005-12-07 Boston Scientific Limited Laser lithotripsy device with suction
US6432102B2 (en) 1999-03-15 2002-08-13 Cryovascular Systems, Inc. Cryosurgical fluid supply
US6648879B2 (en) 1999-02-24 2003-11-18 Cryovascular Systems, Inc. Safety cryotherapy catheter
US6428534B1 (en) 1999-02-24 2002-08-06 Cryovascular Systems, Inc. Cryogenic angioplasty catheter
US6514245B1 (en) 1999-03-15 2003-02-04 Cryovascular Systems, Inc. Safety cryotherapy catheter
US6468297B1 (en) 1999-02-24 2002-10-22 Cryovascular Systems, Inc. Cryogenically enhanced intravascular interventions
EP1158919B1 (en) 1999-03-09 2005-06-29 Thermage, Inc. Apparatus for treatment of tissue
US6484052B1 (en) 1999-03-30 2002-11-19 The Regents Of The University Of California Optically generated ultrasound for enhanced drug delivery
US6911026B1 (en) 1999-07-12 2005-06-28 Stereotaxis, Inc. Magnetically guided atherectomy
US6409723B1 (en) 1999-04-02 2002-06-25 Stuart D. Edwards Treating body tissue by applying energy and substances
US20050010095A1 (en) 1999-04-05 2005-01-13 Medtronic, Inc. Multi-purpose catheter apparatus and method of use
US6325797B1 (en) 1999-04-05 2001-12-04 Medtronic, Inc. Ablation catheter and method for isolating a pulmonary vein
US6702811B2 (en) 1999-04-05 2004-03-09 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US20010007070A1 (en) 1999-04-05 2001-07-05 Medtronic, Inc. Ablation catheter assembly and method for isolating a pulmonary vein
US6577902B1 (en) 1999-04-16 2003-06-10 Tony R. Brown Device for shaping infarcted heart tissue and method of using the device
US6149647A (en) 1999-04-19 2000-11-21 Tu; Lily Chen Apparatus and methods for tissue treatment
US6317615B1 (en) 1999-04-19 2001-11-13 Cardiac Pacemakers, Inc. Method and system for reducing arterial restenosis in the presence of an intravascular stent
US6595959B1 (en) 1999-04-23 2003-07-22 Alexander A. Stratienko Cardiovascular sheath/catheter
US6245045B1 (en) 1999-04-23 2001-06-12 Alexander Andrew Stratienko Combination sheath and catheter for cardiovascular use
US6514236B1 (en) 1999-04-23 2003-02-04 Alexander A. Stratienko Method for treating a cardiovascular condition
US6797960B1 (en) 1999-04-26 2004-09-28 Simage Oy Self triggered imaging device for imaging radiation
US6689142B1 (en) 1999-04-26 2004-02-10 Scimed Life Systems, Inc. Apparatus and methods for guiding a needle
US7226446B1 (en) 1999-05-04 2007-06-05 Dinesh Mody Surgical microwave ablation assembly
US6648854B1 (en) 1999-05-14 2003-11-18 Scimed Life Systems, Inc. Single lumen balloon-tipped micro catheter with reinforced shaft
US6692490B1 (en) 1999-05-18 2004-02-17 Novasys Medical, Inc. Treatment of urinary incontinence and other disorders by application of energy and drugs
EP1180004A1 (en) 1999-05-18 2002-02-20 Silhouette Medical Inc. Surgical weight control device
US7343195B2 (en) 1999-05-18 2008-03-11 Mediguide Ltd. Method and apparatus for real time quantitative three-dimensional image reconstruction of a moving organ and intra-body navigation
GB9911956D0 (en) 1999-05-21 1999-07-21 Gyrus Medical Ltd Electrosurgery system and method
US6375668B1 (en) 1999-06-02 2002-04-23 Hanson S. Gifford Devices and methods for treating vascular malformations
US6391024B1 (en) 1999-06-17 2002-05-21 Cardiac Pacemakers, Inc. RF ablation apparatus and method having electrode/tissue contact assessment scheme and electrocardiogram filtering
SE519023C2 (sv) 1999-06-21 2002-12-23 Micromuscle Ab Kateterburna mikrokirurgiska verktygsset
US6398792B1 (en) 1999-06-21 2002-06-04 O'connor Lawrence Angioplasty catheter with transducer using balloon for focusing of ultrasonic energy and method for use
US6546272B1 (en) 1999-06-24 2003-04-08 Mackinnon Nicholas B. Apparatus for in vivo imaging of the respiratory tract and other internal organs
US7840278B1 (en) 1999-06-25 2010-11-23 Puskas John D Devices and methods for vagus nerve stimulation
US7426409B2 (en) 1999-06-25 2008-09-16 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US6238392B1 (en) 1999-06-29 2001-05-29 Ethicon Endo-Surgery, Inc. Bipolar electrosurgical instrument including a plurality of balloon electrodes
US6179859B1 (en) 1999-07-16 2001-01-30 Baff Llc Emboli filtration system and methods of use
US6508804B2 (en) 1999-07-28 2003-01-21 Scimed Life Systems, Inc. Catheter having continuous lattice and coil reinforcement
US6203561B1 (en) 1999-07-30 2001-03-20 Incept Llc Integrated vascular device having thrombectomy element and vascular filter and methods of use
US7033372B1 (en) 1999-08-04 2006-04-25 Percardia, Inc. Corkscrew reinforced left ventricle to coronary artery channel
US6235044B1 (en) 1999-08-04 2001-05-22 Scimed Life Systems, Inc. Percutaneous catheter and guidewire for filtering during ablation of mycardial or vascular tissue
US7175644B2 (en) 2001-02-14 2007-02-13 Broncus Technologies, Inc. Devices and methods for maintaining collateral channels in tissue
DE29913688U1 (de) 1999-08-05 1999-10-14 Wolf Gmbh Richard Transurethrale Dissektionselektrode
WO2001010314A2 (en) 1999-08-05 2001-02-15 Broncus Technologies, Inc. Methods and devices for creating collateral channels in the lungs
FR2797389B1 (fr) 1999-08-09 2001-11-30 Novatech Inc Prothese aortique bifurquee
US6445939B1 (en) 1999-08-09 2002-09-03 Lightlab Imaging, Llc Ultra-small optical probes, imaging optics, and methods for using same
US7288096B2 (en) 2003-01-17 2007-10-30 Origin Medsystems, Inc. Apparatus for placement of cardiac defibrillator and pacer
US6575966B2 (en) 1999-08-23 2003-06-10 Cryocath Technologies Inc. Endovascular cryotreatment catheter
US6283959B1 (en) 1999-08-23 2001-09-04 Cyrocath Technologies, Inc. Endovascular cryotreatment catheter
US6298256B1 (en) 1999-09-10 2001-10-02 Frank-Egbert Meyer Device and method for the location and catheterization of the surroundings of a nerve
NL1013084C2 (nl) 1999-09-17 2001-03-20 Neopost Bv Instellen van een systeem voor het samenstellen van poststukken.
US6454775B1 (en) 1999-12-06 2002-09-24 Bacchus Vascular Inc. Systems and methods for clot disruption and retrieval
US6829497B2 (en) 1999-09-21 2004-12-07 Jamil Mogul Steerable diagnostic catheters
WO2001022897A1 (en) 1999-09-28 2001-04-05 Novasys Medical, Inc. Treatment of tissue by application of energy and drugs
US6485489B2 (en) 1999-10-02 2002-11-26 Quantum Cor, Inc. Catheter system for repairing a mitral valve annulus
JP2001116565A (ja) 1999-10-15 2001-04-27 Yazaki Corp 車載ナビゲーション装置及び車載ナビゲーション装置における処理プログラムを記録した記録媒体
US6514248B1 (en) 1999-10-15 2003-02-04 Neothermia Corporation Accurate cutting about and into tissue volumes with electrosurgically deployed electrodes
US6669655B1 (en) 1999-10-20 2003-12-30 Transurgical, Inc. Sonic element and catheter incorporating same
US6656136B1 (en) 1999-10-25 2003-12-02 Therus Corporation Use of focused ultrasound for vascular sealing
DE60037747T2 (de) 1999-11-10 2008-12-11 Cytyc Surgical Products, Palo Alto System zum feststellen von perforationen in einem körperhohlraum
US6542781B1 (en) 1999-11-22 2003-04-01 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6529756B1 (en) 1999-11-22 2003-03-04 Scimed Life Systems, Inc. Apparatus for mapping and coagulating soft tissue in or around body orifices
JP4854900B2 (ja) 1999-11-24 2012-01-18 ヌバシブ， インコーポレイテッド 筋電計測法
US6280466B1 (en) 1999-12-03 2001-08-28 Teramed Inc. Endovascular graft system
US6592567B1 (en) 1999-12-07 2003-07-15 Chf Solutions, Inc. Kidney perfusion catheter
US7097641B1 (en) 1999-12-09 2006-08-29 Cryocath Technologies Inc. Catheter with cryogenic and heating ablation
US7494485B2 (en) 1999-12-10 2009-02-24 Sprite Solutions Fluidic interventional device and method of distal protection
US6800075B2 (en) 1999-12-10 2004-10-05 Sprite Solutions Method to inject and extract fluid at a treatment site to remove debris
US6480745B2 (en) 1999-12-24 2002-11-12 Medtronic, Inc. Information network interrogation of an implanted device
US6494891B1 (en) 1999-12-30 2002-12-17 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty transmission member
US6440125B1 (en) 2000-01-04 2002-08-27 Peter Rentrop Excimer laser catheter
US6328699B1 (en) 2000-01-11 2001-12-11 Cedars-Sinai Medical Center Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure
US6692450B1 (en) 2000-01-19 2004-02-17 Medtronic Xomed, Inc. Focused ultrasound ablation devices having selectively actuatable ultrasound emitting elements and methods of using the same
US6623453B1 (en) 2000-01-19 2003-09-23 Vanny Corporation Chemo-thermo applicator for cancer treatment
US7706882B2 (en) 2000-01-19 2010-04-27 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area
US6447443B1 (en) 2001-01-13 2002-09-10 Medtronic, Inc. Method for organ positioning and stabilization
US7184827B1 (en) 2000-01-24 2007-02-27 Stuart D. Edwards Shrinkage of dilatations in the body
US6569109B2 (en) 2000-02-04 2003-05-27 Olympus Optical Co., Ltd. Ultrasonic operation apparatus for performing follow-up control of resonance frequency drive of ultrasonic oscillator by digital PLL system using DDS (direct digital synthesizer)
US6457365B1 (en) 2000-02-09 2002-10-01 Endosonics Corporation Method and apparatus for ultrasonic imaging
US6663622B1 (en) 2000-02-11 2003-12-16 Iotek, Inc. Surgical devices and methods for use in tissue ablation procedures
US6158250A (en) 2000-02-14 2000-12-12 Novacept Flat-bed knitting machine and method of knitting
US7499745B2 (en) 2000-02-28 2009-03-03 Barbara Ann Karmanos Cancer Institute Multidimensional bioelectrical tissue analyzer
US6394956B1 (en) 2000-02-29 2002-05-28 Scimed Life Systems, Inc. RF ablation and ultrasound catheter for crossing chronic total occlusions
US6458098B1 (en) 2000-03-17 2002-10-01 Nozomu Kanesaka Vascular therapy device
US6770070B1 (en) 2000-03-17 2004-08-03 Rita Medical Systems, Inc. Lung treatment apparatus and method
WO2001072373A2 (en) 2000-03-24 2001-10-04 Transurgical, Inc. Apparatus and method for intrabody thermal treatment
US6471696B1 (en) 2000-04-12 2002-10-29 Afx, Inc. Microwave ablation instrument with a directional radiation pattern
WO2001082812A1 (en) 2000-04-27 2001-11-08 Medtronic, Inc. Vibration sensitive ablation apparatus and method
US20020107514A1 (en) 2000-04-27 2002-08-08 Hooven Michael D. Transmural ablation device with parallel jaws
US6558382B2 (en) 2000-04-27 2003-05-06 Medtronic, Inc. Suction stabilized epicardial ablation devices
EP1642544B1 (en) 2000-05-03 2009-04-08 C.R.Bard, Inc. Apparatus for mapping and ablation in electrophysiology procedures
EP1280467B8 (en) 2000-05-12 2009-11-18 Cardima, Inc. Multi-channel rf energy delivery with coagulum reduction
US7252664B2 (en) 2000-05-12 2007-08-07 Cardima, Inc. System and method for multi-channel RF energy delivery with coagulum reduction
US7006858B2 (en) 2000-05-15 2006-02-28 Silver James H Implantable, retrievable sensors and immunosensors
US7181261B2 (en) 2000-05-15 2007-02-20 Silver James H Implantable, retrievable, thrombus minimizing sensors
US6442413B1 (en) 2000-05-15 2002-08-27 James H. Silver Implantable sensor
WO2001087154A1 (en) 2000-05-18 2001-11-22 Nuvasive, Inc. Tissue discrimination and applications in medical procedures
US6544780B1 (en) 2000-06-02 2003-04-08 Genphar, Inc. Adenovirus vector with multiple expression cassettes
US6511500B1 (en) 2000-06-06 2003-01-28 Marc Mounir Rahme Use of autonomic nervous system neurotransmitters inhibition and atrial parasympathetic fibers ablation for the treatment of atrial arrhythmias and to preserve drug effects
US20020022864A1 (en) 2000-06-07 2002-02-21 Mahvi David M. Multipolar electrode system for radiofrequency ablation
DE60109444T2 (de) 2000-06-13 2006-04-13 Atrionix, Inc., Irwindale Chirurgische ablationssonde zum formen einer ringförmigen läsion
US7837720B2 (en) 2000-06-20 2010-11-23 Boston Scientific Corporation Apparatus for treatment of tissue adjacent a bodily conduit with a gene or drug-coated compression balloon
US6958075B2 (en) 2001-09-18 2005-10-25 Celsion Corporation Device and method for treatment of tissue adjacent a bodily conduit by thermocompression
US6477426B1 (en) 2000-06-20 2002-11-05 Celsion Corporation System and method for heating the prostate gland to treat and prevent the growth and spread of prostate tumors
AU2001270219A1 (en) 2000-06-28 2002-01-08 Ira Sanders Methods for using tetanus toxin for benificial purposes in animals (mammals)
US6511478B1 (en) 2000-06-30 2003-01-28 Scimed Life Systems, Inc. Medical probe with reduced number of temperature sensor wires
US6638277B2 (en) 2000-07-06 2003-10-28 Scimed Life Systems, Inc. Tumor ablation needle with independently activated and independently traversing tines
AU2002218742A1 (en) 2000-07-11 2002-01-21 Johns Hopkins University Application of photochemotherapy for the treatment of cardiac arrhythmias
EP1299035B1 (en) 2000-07-13 2013-02-13 ReCor Medical, Inc. Thermal treatment apparatus with focussed energy application
DE10038737A1 (de) 2000-08-02 2002-02-14 Oliver Wendt Katheter für magnetresonanztomographische Untersuchungen
US7678106B2 (en) 2000-08-09 2010-03-16 Halt Medical, Inc. Gynecological ablation procedure and system
US6699241B2 (en) 2000-08-11 2004-03-02 Northeastern University Wide-aperture catheter-based microwave cardiac ablation antenna
US7789876B2 (en) 2000-08-14 2010-09-07 Tyco Healthcare Group, Lp Method and apparatus for positioning a catheter relative to an anatomical junction
US20040010118A1 (en) 2000-08-16 2004-01-15 Zerhusen Bryan D. Novel proteins and nucleic acids encoding same
US6497711B1 (en) 2000-08-16 2002-12-24 Scimed Life Systems, Inc. Therectomy device having a light weight drive shaft and an imaging device
US6955174B2 (en) 2000-08-18 2005-10-18 Uryovascular Systems, Inc. Cryotherapy method for detecting and treating vulnerable plaque
US6602246B1 (en) 2000-08-18 2003-08-05 Cryovascular Systems, Inc. Cryotherapy method for detecting and treating vulnerable plaque
US6669692B1 (en) 2000-08-21 2003-12-30 Biosense Webster, Inc. Ablation catheter with cooled linear electrode
EP1319408B1 (en) 2000-09-08 2010-07-28 Daiichi Sankyo Company, Limited Remedies for heart failure
US6511496B1 (en) 2000-09-12 2003-01-28 Advanced Cardiovascular Systems, Inc. Embolic protection device for use in interventional procedures
US6985774B2 (en) 2000-09-27 2006-01-10 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US7158832B2 (en) 2000-09-27 2007-01-02 Cvrx, Inc. Electrode designs and methods of use for cardiovascular reflex control devices
US6522926B1 (en) 2000-09-27 2003-02-18 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US6845267B2 (en) 2000-09-28 2005-01-18 Advanced Bionics Corporation Systems and methods for modulation of circulatory perfusion by electrical and/or drug stimulation
US6470219B1 (en) 2000-10-02 2002-10-22 Novasys Medical, Inc. Apparatus and method for treating female urinary incontinence
US6527765B2 (en) 2000-10-06 2003-03-04 Charles D. Kelman Cryogenic surgical system and method of use in removal of tissue
US6802857B1 (en) 2000-10-11 2004-10-12 Uab Research Foundation MRI stent
US6475215B1 (en) 2000-10-12 2002-11-05 Naim Erturk Tanrisever Quantum energy surgical device and method
US7104987B2 (en) 2000-10-17 2006-09-12 Asthmatx, Inc. Control system and process for application of energy to airway walls and other mediums
US7646544B2 (en) 2005-05-14 2010-01-12 Batchko Robert G Fluidic optical devices
US6706037B2 (en) 2000-10-24 2004-03-16 Galil Medical Ltd. Multiple cryoprobe apparatus and method
US6616624B1 (en) 2000-10-30 2003-09-09 Cvrx, Inc. Systems and method for controlling renovascular perfusion
US20070292411A1 (en) 2000-11-08 2007-12-20 Human Genome Sciences, Inc. Antibodies That Immunospecifically Bind to TRAIL Receptors
US20060062786A1 (en) 2000-11-08 2006-03-23 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US6673066B2 (en) 2000-11-10 2004-01-06 Cardiostream, Inc. Apparatus and method to diagnose and treat vulnerable plaque
JP5377813B2 (ja) 2000-11-16 2013-12-25 コヴィディエン リミテッド パートナーシップ ヒト食道内の異常組織を処置するシステム及び方法
US7314483B2 (en) 2000-11-16 2008-01-01 Cordis Corp. Stent graft with branch leg
US6942692B2 (en) 2000-11-16 2005-09-13 Cordis Corporation Supra-renal prosthesis and renal artery bypass
AU2002226347A1 (en) 2000-11-24 2002-06-18 Innovacell Biotechnologie Gmbh Ultrasonic probe comprising a positioning device for examination devices and operation devices
US6579308B1 (en) 2000-11-28 2003-06-17 Scimed Life Systems, Inc. Stent devices with detachable distal or proximal wires
US7081114B2 (en) 2000-11-29 2006-07-25 St. Jude Medical, Atrial Fibrillation Division, Inc. Electrophysiology/ablation catheter having lariat configuration of variable radius
US6676657B2 (en) 2000-12-07 2004-01-13 The United States Of America As Represented By The Department Of Health And Human Services Endoluminal radiofrequency cauterization system
US6659981B2 (en) 2000-12-08 2003-12-09 Medtronic, Inc. Medical device delivery catheter with distal locator
US6623452B2 (en) 2000-12-19 2003-09-23 Scimed Life Systems, Inc. Drug delivery catheter having a highly compliant balloon with infusion holes
US20020087151A1 (en) 2000-12-29 2002-07-04 Afx, Inc. Tissue ablation apparatus with a sliding ablation instrument and method
JP4281992B2 (ja) 2001-01-16 2009-06-17 サイティック・サージカル・プロダクツ 静脈逆流処置方法及び装置
ES2303851T3 (es) 2001-01-19 2008-09-01 Boston Scientific Limited Introductor para el despliegue de protesis ramificada.
US6569177B1 (en) 2001-01-19 2003-05-27 Scimed Life Systems, Inc. Ablation atherectomy burr
US20020107536A1 (en) 2001-02-07 2002-08-08 Hussein Hany M. Device and method for preventing kidney failure
US6823205B1 (en) 2001-02-08 2004-11-23 Boston University Radiology Associates Synthetic images for a magnetic resonance imaging scanner using linear combination of source images to generate contrast and spatial navigation
IL157364A0 (en) 2001-02-16 2004-02-19 Daiichi Suntory Pharma Co Ltd Therapeutic methods and agents for diseases associated with decreased expression of aop-1 gene or aop-1
AUPR333301A0 (en) 2001-02-23 2001-03-22 Northern Sydney Area Health Service Determining the volume of a normal heart and its pathological and treated variants by using dimension sensors
US6681773B2 (en) 2001-02-28 2004-01-27 Chase Medical, Inc. Kit and method for use during ventricular restoration
US6564096B2 (en) 2001-02-28 2003-05-13 Robert A. Mest Method and system for treatment of tachycardia and fibrillation
US6666863B2 (en) 2001-03-01 2003-12-23 Scimed Life Systems, Inc. Device and method for percutaneous myocardial revascularization
US6786904B2 (en) 2002-01-10 2004-09-07 Triton Biosystems, Inc. Method and device to treat vulnerable plaque
US6909009B2 (en) 2001-03-08 2005-06-21 Avtandil Koridze Alkane and alkane group dehydrogenation with organometallic catalysts
US6570659B2 (en) 2001-03-16 2003-05-27 Lightlab Imaging, Llc Broadband light source system and method and light source combiner
US6623444B2 (en) 2001-03-21 2003-09-23 Advanced Medical Applications, Inc. Ultrasonic catheter drug delivery method and device
US20020147480A1 (en) 2001-04-04 2002-10-10 Mamayek Donald S. Treatment of lipid pool
US6552796B2 (en) 2001-04-06 2003-04-22 Lightlab Imaging, Llc Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography
US6764501B2 (en) 2001-04-10 2004-07-20 Robert A. Ganz Apparatus and method for treating atherosclerotic vascular disease through light sterilization
US6666858B2 (en) 2001-04-12 2003-12-23 Scimed Life Systems, Inc. Cryo balloon for atrial ablation
US20050232921A1 (en) 2001-04-13 2005-10-20 Rosen Craig A Vascular endothelial growth factor 2
US7402312B2 (en) 2001-04-13 2008-07-22 Human Genome Sciences, Inc. Antibodies to vascular endothelial growth factor 2 (VEGF-2)
US6989010B2 (en) 2001-04-26 2006-01-24 Medtronic, Inc. Ablation system and method of use
US6645223B2 (en) 2001-04-30 2003-11-11 Advanced Cardiovascular Systems, Inc. Deployment and recovery control systems for embolic protection devices
US20040187875A1 (en) 2001-05-01 2004-09-30 He Sheng Ding Method and apparatus for altering conduction properties along pathways in the heart and in vessels in conductive communication with the heart.
US20020169444A1 (en) 2001-05-08 2002-11-14 Mest Robert A. Catheter having continuous braided electrode
WO2002089686A1 (en) 2001-05-10 2002-11-14 Rita Medical Systems, Inc. Rf tissue ablation apparatus and method
WO2002094363A2 (en) 2001-05-21 2002-11-28 Medtronic,Inc. Trans-septal catheter with retention mechanism
US6771996B2 (en) 2001-05-24 2004-08-03 Cardiac Pacemakers, Inc. Ablation and high-resolution mapping catheter system for pulmonary vein foci elimination
US7348003B2 (en) 2001-05-25 2008-03-25 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
US20050129616A1 (en) 2001-05-25 2005-06-16 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US7361341B2 (en) 2001-05-25 2008-04-22 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
US20050214210A1 (en) 2001-05-25 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US20090226429A1 (en) 2001-05-25 2009-09-10 Human Genome Sciences, Inc. Antibodies That Immunospecifically Bind to TRAIL Receptors
US20050214209A1 (en) 2001-05-25 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
EP1401506A4 (en) 2001-05-31 2005-02-16 Miravant Pharm Inc METAL TETRAPYRROLIC PHOTOSENSITIZATION AGENTS FOR PHOTODYNAMIC THERAPY
US20020198520A1 (en) 2001-06-20 2002-12-26 Scimed Life Systems, Inc. Irrigation sheath
US6797933B1 (en) 2001-06-29 2004-09-28 Vanguard International Semiconductor Corporation On-chip design-for-testing structure for CMOS APS (active pixel sensor) image sensor
US6605056B2 (en) 2001-07-11 2003-08-12 Scimed Life Systems, Inc. Conformable balloon
US20060167498A1 (en) 2001-07-23 2006-07-27 Dilorenzo Daniel J Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of disease
US20040043030A1 (en) 2001-07-31 2004-03-04 Immunomedics, Inc. Polymeric delivery systems
CA2456047A1 (en) 2001-08-08 2003-02-20 Canica Design Inc. Surgical retractor and tissue stabilization device
US6786900B2 (en) 2001-08-13 2004-09-07 Cryovascular Systems, Inc. Cryotherapy methods for treating vessel dissections and side branch occlusion
US6600956B2 (en) 2001-08-21 2003-07-29 Cyberonics, Inc. Circumneural electrode assembly
US20030050635A1 (en) 2001-08-22 2003-03-13 Csaba Truckai Embolization systems and techniques for treating tumors
US8287524B2 (en) 2001-08-23 2012-10-16 Jerry Siegel Apparatus and method for performing radiation energy treatments
AU2002324775A1 (en) 2001-08-23 2003-03-10 Sciperio, Inc. Architecture tool and methods of use
WO2003020138A1 (en) 2001-08-31 2003-03-13 Scimed Life Systems, Inc. Percutaneous pringle occlusion device
US6962584B1 (en) 2001-09-06 2005-11-08 Stone Gregg W Electromagnetic photonic catheter for reducing restenosis
US7252679B2 (en) 2001-09-13 2007-08-07 Cordis Corporation Stent with angulated struts
WO2003024309A2 (en) 2001-09-19 2003-03-27 Urologix, Inc. Microwave ablation device
AU2002305767B2 (en) 2001-09-20 2008-04-10 Cornell Research Foundation, Inc. Methods and compositions for treating and preventing skin disorders using binding agents specific for PSMA
US6723043B2 (en) 2001-09-25 2004-04-20 Sdgi Holdings, Inc. Methods and devices for inserting and manipulating surgical instruments
US7344533B2 (en) 2001-09-28 2008-03-18 Angiodynamics, Inc. Impedance controlled tissue ablation apparatus and method
JP3607231B2 (ja) 2001-09-28 2005-01-05 有限会社日本エレクテル 高周波加温バルーンカテーテル
JP2003111848A (ja) 2001-10-05 2003-04-15 Nihon Medix 加熱式バルーンカテーテル装置およびその加熱方法
CA2462968C (en) 2001-10-06 2012-11-20 Medos S.A. Method of setting and actuating a multi-stable micro valve and adjustable micro valve
US6814730B2 (en) 2001-10-09 2004-11-09 Hong Li Balloon catheters for non-continuous lesions
US6926716B2 (en) 2001-11-09 2005-08-09 Surgrx Inc. Electrosurgical instrument
AUPR847201A0 (en) 2001-10-26 2001-11-15 Cook Incorporated Endoluminal graft
US6807444B2 (en) 2001-11-05 2004-10-19 Hosheng Tu Apparatus and methods for monitoring tissue impedance
US20030092995A1 (en) 2001-11-13 2003-05-15 Medtronic, Inc. System and method of positioning implantable medical devices
US7317077B2 (en) 2001-11-16 2008-01-08 Nymox Pharmaceutical Corporation Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells
WO2003043685A2 (en) 2001-11-19 2003-05-30 Cardiovascular Systems, Inc High torque, low profile intravascular guidewire system
US6895077B2 (en) 2001-11-21 2005-05-17 University Of Massachusetts Medical Center System and method for x-ray fluoroscopic imaging
US8353945B2 (en) 2001-12-03 2013-01-15 J.W. Medical System Ltd. Delivery catheter having active engagement mechanism for prosthesis
ATE520362T1 (de) 2001-12-03 2011-09-15 Ekos Corp Katheter mit mehreren ultraschall-abstrahlenden teilen
US20050149069A1 (en) 2001-12-04 2005-07-07 Bertolero Arthur A. Left atrial appendage devices and methods
US6849075B2 (en) 2001-12-04 2005-02-01 Estech, Inc. Cardiac ablation devices and methods
US6709431B2 (en) 2001-12-18 2004-03-23 Scimed Life Systems, Inc. Cryo-temperature monitoring
US20050214208A1 (en) 2001-12-20 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
WO2003054216A2 (en) 2001-12-20 2003-07-03 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
US20050214207A1 (en) 2001-12-20 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind toTRAIL receptors
US20050214205A1 (en) 2001-12-20 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US6972024B1 (en) 2001-12-21 2005-12-06 Advanced Cardiovascular Systems, Inc. Method of treating vulnerable plaque
US6893436B2 (en) 2002-01-03 2005-05-17 Afx, Inc. Ablation instrument having a flexible distal portion
US7326237B2 (en) 2002-01-08 2008-02-05 Cordis Corporation Supra-renal anchoring prosthesis
ATE503982T1 (de) 2002-01-11 2011-04-15 Gen Hospital Corp Vorrichtung zur oct bildaufnahme mit axialem linienfokus für verbesserte auflösung und tiefenschärfe
US6790206B2 (en) 2002-01-31 2004-09-14 Scimed Life Systems, Inc. Compensation for power variation along patient cables
US6814733B2 (en) 2002-01-31 2004-11-09 Biosense, Inc. Radio frequency pulmonary vein isolation
US6826830B2 (en) 2002-02-05 2004-12-07 International Business Machines Corporation Multi-layered interconnect structure using liquid crystalline polymer dielectric
US6949121B1 (en) 2002-02-07 2005-09-27 Sentient Engineering & Technology, Llc Apparatus and methods for conduits and materials
MXPA04007897A (es) 2002-02-15 2004-11-26 Celsion Corp Metodo y aparato para tratar el tejido adyacente a un conducto corporal con termocompresion y farmacos.
US7192427B2 (en) 2002-02-19 2007-03-20 Afx, Inc. Apparatus and method for assessing transmurality of a tissue ablation
KR20040094709A (ko) 2002-02-21 2004-11-10 와이어쓰 폴리스타틴 도메인을 포함하는 단백질
US7294127B2 (en) 2002-03-05 2007-11-13 Baylis Medical Company Inc. Electrosurgical tissue treatment method
US6824516B2 (en) 2002-03-11 2004-11-30 Medsci Technologies, Inc. System for examining, mapping, diagnosing, and treating diseases of the prostate
ATE369084T1 (de) 2002-03-15 2007-08-15 Bard Inc C R Apparat zur steuerung von ablationsenergie und elektrogrammaufnahme mittels einer vielzahl gemeinsamer elektroden in einem elektrophysiologie-katheter
ITBS20020039U1 (it) 2002-03-20 2003-09-22 Fogazzi Di Venturelli Andrea & Catetere con elettrodo flessibile raffreddato
US7087026B2 (en) 2002-03-21 2006-08-08 Radiant Medical, Inc. Devices and methods for measuring blood flow rate or cardiac output and for heating or cooling the body
US6979420B2 (en) 2002-03-28 2005-12-27 Scimed Life Systems, Inc. Method of molding balloon catheters employing microwave energy
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US20110207758A1 (en) 2003-04-08 2011-08-25 Medtronic Vascular, Inc. Methods for Therapeutic Renal Denervation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US8150520B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US6685733B1 (en) 2002-04-10 2004-02-03 Radiant Medical, Inc. Methods and systems for reducing substance-induced renal damage
US20050256398A1 (en) 2004-05-12 2005-11-17 Hastings Roger N Systems and methods for interventional medicine
DE10217559B4 (de) 2002-04-19 2004-02-19 Universitätsklinikum Freiburg Vorrichtung zur minimalinvasiven, intravasalen Aortenklappenextraktion
US20030199747A1 (en) 2002-04-19 2003-10-23 Michlitsch Kenneth J. Methods and apparatus for the identification and stabilization of vulnerable plaque
US6989009B2 (en) 2002-04-19 2006-01-24 Scimed Life Systems, Inc. Cryo balloon
US6746401B2 (en) 2002-05-06 2004-06-08 Scimed Life Systems, Inc. Tissue ablation visualization
CN1653297B (zh) 2002-05-08 2010-09-29 佛森技术公司 高效固态光源及其使用和制造方法
AUPS226402A0 (en) 2002-05-13 2002-06-13 Advanced Metal Coatings Pty Limited An ablation catheter
US6746474B2 (en) 2002-05-31 2004-06-08 Vahid Saadat Apparatus and methods for cooling a region within the body
US6748953B2 (en) 2002-06-11 2004-06-15 Scimed Life Systems, Inc. Method for thermal treatment of type II endoleaks in arterial aneurysms
US7153315B2 (en) 2002-06-11 2006-12-26 Boston Scientific Scimed, Inc. Catheter balloon with ultrasonic microscalpel blades
US7611529B2 (en) 2002-06-28 2009-11-03 Cook Incorporated Thoracic introducer
GB2390545B (en) 2002-07-09 2005-04-20 Barts & London Nhs Trust Hollow organ probe
US7769427B2 (en) 2002-07-16 2010-08-03 Magnetics, Inc. Apparatus and method for catheter guidance control and imaging
US6866662B2 (en) 2002-07-23 2005-03-15 Biosense Webster, Inc. Ablation catheter having stabilizing array
JP4602080B2 (ja) 2002-07-25 2010-12-22 ボストン サイエンティフィック リミテッド 人体構造内を進行する医療用具
US8920826B2 (en) 2002-07-31 2014-12-30 Boston Scientific Scimed, Inc. Medical imaging reference devices
US6702748B1 (en) 2002-09-20 2004-03-09 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
TWI235073B (en) 2002-08-20 2005-07-01 Toray Industries Catheter for treating cardiac arrhythmias
US6991617B2 (en) 2002-08-21 2006-01-31 Hektner Thomas R Vascular treatment method and device
US6942677B2 (en) 2003-02-26 2005-09-13 Flowcardia, Inc. Ultrasound catheter apparatus
US7220233B2 (en) 2003-04-08 2007-05-22 Flowcardia, Inc. Ultrasound catheter devices and methods
US7335180B2 (en) 2003-11-24 2008-02-26 Flowcardia, Inc. Steerable ultrasound catheter
US7604608B2 (en) 2003-01-14 2009-10-20 Flowcardia, Inc. Ultrasound catheter and methods for making and using same
US7137963B2 (en) 2002-08-26 2006-11-21 Flowcardia, Inc. Ultrasound catheter for disrupting blood vessel obstructions
US6929639B2 (en) 2002-08-30 2005-08-16 Scimed Life Systems, Inc. Cryo ablation coil
US7063679B2 (en) 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
WO2005037105A1 (en) 2002-09-20 2005-04-28 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
EP1585572A4 (en) 2002-09-20 2010-02-24 Flowmedica Inc METHOD AND APPARATUS FOR ADMINISTERING INTRA-AORTIC SUBSTANCE TO A BRANCHED VESSEL
US7282213B2 (en) 2002-09-30 2007-10-16 Medtronic, Inc. Method for applying a drug coating to a medical device
EP1405613B1 (en) 2002-10-04 2006-03-22 Sorin Biomedica Cardio S.R.L. An implant device for treating aneurisms of the abdominal aorta
US6673101B1 (en) 2002-10-09 2004-01-06 Endovascular Technologies, Inc. Apparatus and method for deploying self-expanding stents
US7493154B2 (en) 2002-10-23 2009-02-17 Medtronic, Inc. Methods and apparatus for locating body vessels and occlusions in body vessels
US7404824B1 (en) 2002-11-15 2008-07-29 Advanced Cardiovascular Systems, Inc. Valve aptation assist device
US7599730B2 (en) 2002-11-19 2009-10-06 Medtronic Navigation, Inc. Navigation system for cardiac therapies
US6926713B2 (en) 2002-12-11 2005-08-09 Boston Scientific Scimed, Inc. Angle indexer for medical devices
KR100887669B1 (ko) 2002-12-28 2009-03-11 엘지디스플레이 주식회사 액정표시장치 및 그 제조방법
US20050154277A1 (en) 2002-12-31 2005-07-14 Jing Tang Apparatus and methods of using built-in micro-spectroscopy micro-biosensors and specimen collection system for a wireless capsule in a biological body in vivo
EP1583569A4 (en) 2003-01-03 2009-05-06 Ekos Corp ULTRASONIC CATHETER COMPRISING AN AXIAL ENERGY FIELD
US6847848B2 (en) 2003-01-07 2005-01-25 Mmtc, Inc Inflatable balloon catheter structural designs and methods for treating diseased tissue of a patient
US7087051B2 (en) 2003-01-15 2006-08-08 Boston Scientific Scimed, Inc. Articulating radio frequency probe handle
US7083612B2 (en) 2003-01-15 2006-08-01 Cryodynamics, Llc Cryotherapy system
US6960207B2 (en) 2003-01-21 2005-11-01 St Jude Medical, Daig Division, Inc. Ablation catheter having a virtual electrode comprising portholes and a porous conductor
US7819866B2 (en) 2003-01-21 2010-10-26 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation catheter and electrode
JP4067976B2 (ja) 2003-01-24 2008-03-26 有限会社日本エレクテル 高周波加温バルーンカテーテル
KR20050098277A (ko) 2003-01-29 2005-10-11 이-필 파마 리미티드 위장관 내 약물의 능동 송달
US20040193211A1 (en) 2003-02-14 2004-09-30 Voegele James W. Fingertip surgical instruments
US7201749B2 (en) 2003-02-19 2007-04-10 Biosense, Inc. Externally-applied high intensity focused ultrasound (HIFU) for pulmonary vein isolation
EP1596746B1 (en) 2003-02-20 2016-10-19 ReCor Medical, Inc. Ultrasonic ablation devices
US8465452B2 (en) 2003-02-21 2013-06-18 3Dt Holdings, Llc Devices, systems, and methods for removing stenotic lesions from vessels
US7818053B2 (en) 2003-02-21 2010-10-19 Dtherapeutics, Llc Devices, systems and methods for plaque type determination
US9603545B2 (en) 2003-02-21 2017-03-28 3Dt Holdings, Llc Devices, systems, and methods for removing targeted lesions from vessels
US6923808B2 (en) 2003-02-24 2005-08-02 Boston Scientific Scimed, Inc. Probes having helical and loop shaped inflatable therapeutic elements
US20040167506A1 (en) 2003-02-25 2004-08-26 Scimed Life Systems, Inc. Medical devices employing ferromagnetic heating
US7314480B2 (en) 2003-02-27 2008-01-01 Boston Scientific Scimed, Inc. Rotating balloon expandable sheath bifurcation delivery
DE10308383A1 (de) 2003-02-27 2004-09-16 Storz Endoskop Produktions Gmbh Verfahren und optisches System zur Vermessung der Topographie eines Meßobjekts
US7250041B2 (en) 2003-03-12 2007-07-31 Abbott Cardiovascular Systems Inc. Retrograde pressure regulated infusion
US20050015125A1 (en) 2003-03-14 2005-01-20 Mioduski Paul C. Hyperthermia treatment systems and methods
US7792568B2 (en) 2003-03-17 2010-09-07 Boston Scientific Scimed, Inc. MRI-visible medical devices
US8021362B2 (en) 2003-03-27 2011-09-20 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7972330B2 (en) 2003-03-27 2011-07-05 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7293562B2 (en) 2003-03-27 2007-11-13 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US6953425B2 (en) 2003-04-25 2005-10-11 Medtronic Vascular, Inc. Method of treating vulnerable plaque using a catheter-based radiation system
US7597704B2 (en) 2003-04-28 2009-10-06 Atritech, Inc. Left atrial appendage occlusion device with active expansion
US20040243022A1 (en) 2003-04-29 2004-12-02 Medtronic Vascular, Inc. Method and system of detecting vulnerable plaque by sensing motion of thin fibrous cap
EP1620156B1 (en) 2003-05-02 2009-07-29 Boston Scientific Limited Multi-functional medical catheter
US7279600B2 (en) 2003-05-02 2007-10-09 Wyeth Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents
CL2004000985A1 (es) 2003-05-16 2005-01-14 Wyeth Corp Compuestos derivados de fenilquinolinas; composicion farmaceutica, proceso de preparacion; y uso para tratar osteoporosis, enfermedad de paget, dano vascular, osteoartritis, cancer oseo, cancer ovarico, cancer prostatico, hipercolesterolemia, aterosc
JP2004337400A (ja) 2003-05-16 2004-12-02 Terumo Corp 薬剤投与キット
ATE350366T1 (de) 2003-05-16 2007-01-15 Wyeth Corp Aryl-carbaldehyd oxime-verbindungen und deren verwendung als oestrogenwirksame substanzen
US7285120B2 (en) 2003-05-27 2007-10-23 Venture Manufacturing, Llc Balloon centered radially expanding ablation device
US7758520B2 (en) 2003-05-27 2010-07-20 Boston Scientific Scimed, Inc. Medical device having segmented construction
US6932776B2 (en) 2003-06-02 2005-08-23 Meridian Medicalssystems, Llc Method and apparatus for detecting and treating vulnerable plaques
AU2004251673B2 (en) 2003-06-04 2010-01-28 Synecor Llc Intravascular electrophysiological system and methods
US7738952B2 (en) 2003-06-09 2010-06-15 Palo Alto Investors Treatment of conditions through modulation of the autonomic nervous system
US20050017713A1 (en) 2003-06-09 2005-01-27 Jentek Sensors, Inc. Weld characterization using eddy current sensors and arrays
WO2004110258A2 (en) 2003-06-10 2004-12-23 Cardiofocus, Inc. Guided cardiac ablation catheters
US20080208169A1 (en) 2003-06-11 2008-08-28 Boyle Edward M Jr Body-Space Treatment Catheter
US7112196B2 (en) 2003-06-13 2006-09-26 Piezo Technologies, Inc. Multi-element array for acoustic ablation
DE10328816A1 (de) 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Implantierbare Stimulationselektrode mit einer Beschichtung zur Erhöhung der Gewebsverträglichkeit
US7066895B2 (en) 2003-06-30 2006-06-27 Ethicon, Inc. Ultrasonic radial focused transducer for pulmonary vein ablation
US7678104B2 (en) 2003-07-17 2010-03-16 Biosense Webster, Inc. Ultrasound ablation catheter and method for its use
US7670335B2 (en) 2003-07-21 2010-03-02 Biosense Webster, Inc. Ablation device with spiral array ultrasound transducer
US7479157B2 (en) 2003-08-07 2009-01-20 Boston Scientific Scimed, Inc. Stent designs which enable the visibility of the inside of the stent during MRI
US7250440B2 (en) 2003-08-12 2007-07-31 Wyeth (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents
US7294125B2 (en) 2003-08-22 2007-11-13 Scimed Life Systems, Inc. Methods of delivering energy to body portions to produce a therapeutic response
US7313430B2 (en) 2003-08-28 2007-12-25 Medtronic Navigation, Inc. Method and apparatus for performing stereotactic surgery
EP2452648B1 (en) 2003-09-12 2016-02-10 Vessix Vascular, Inc. System for selectable eccentric remodeling and/or ablation of atherosclerotic material
US7569052B2 (en) 2003-09-12 2009-08-04 Boston Scientific Scimed, Inc. Ablation catheter with tissue protecting assembly
US7736362B2 (en) 2003-09-15 2010-06-15 Boston Scientific Scimed, Inc. Catheter balloons
US7758510B2 (en) 2003-09-19 2010-07-20 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
US7435248B2 (en) 2003-09-26 2008-10-14 Boston Scientific Scimed, Inc. Medical probes for creating and diagnosing circumferential lesions within or around the ostium of a vessel
US8029503B2 (en) 2003-10-11 2011-10-04 The Regents Of The University Of California Nerve repair by selective surgical repair of axons
US7280863B2 (en) 2003-10-20 2007-10-09 Magnetecs, Inc. System and method for radar-assisted catheter guidance and control
US7480532B2 (en) 2003-10-22 2009-01-20 Cvrx, Inc. Baroreflex activation for pain control, sedation and sleep
KR100573976B1 (ko) 2003-10-28 2006-04-26 삼성전자주식회사 전사벨트의 구동방법
WO2005041810A2 (en) 2003-11-03 2005-05-12 B-Balloon Ltd. Treatment of vascular bifurcations
JP2007513083A (ja) 2003-11-10 2007-05-24 アンジオテック インターナショナル アーゲー 医療用移植片および繊維誘発剤
CA2536042A1 (en) 2003-11-10 2005-06-02 Angiotech International Ag Medical implants and anti-scarring agents
AU2004289362A1 (en) 2003-11-10 2005-05-26 Angiotech International Ag Intravascular devices and fibrosis-inducing agents
US7367970B2 (en) 2003-11-11 2008-05-06 Biosense Webster Inc. Externally applied RF for pulmonary vein isolation
WO2005051224A2 (en) 2003-11-25 2005-06-09 F.D. Cardio Ltd. Stent positioning using inflation tube
US7896873B2 (en) 2003-12-01 2011-03-01 Biotronik Crm Patent Ag Electrode catheter for the electrotherapy of cardiac tissue
EP1693043B8 (en) 2003-12-02 2011-01-12 Fuso Pharmaceutical Industries Ltd. Dual-chamber container
US20050148842A1 (en) 2003-12-22 2005-07-07 Leming Wang Positioning devices and methods for in vivo wireless imaging capsules
JP4391221B2 (ja) 2003-12-22 2009-12-24 有限会社日本エレクテル 高周波加温バルーンカテーテル
US7686841B2 (en) 2003-12-29 2010-03-30 Boston Scientific Scimed, Inc. Rotating balloon expandable sheath bifurcation delivery system
JPWO2005065559A1 (ja) 2004-01-06 2007-12-20 東レ株式会社 バルーンカテーテル
US7326206B2 (en) 2004-01-16 2008-02-05 St. Jude Medical, Atrial Fibrillation Division, Inc. Conforming-electrode catheter and method for ablation
US7371231B2 (en) 2004-02-02 2008-05-13 Boston Scientific Scimed, Inc. System and method for performing ablation using a balloon
KR100605849B1 (ko) 2004-02-09 2006-08-01 삼성전자주식회사 휴대용 단말기의 데이터 저장 및 재생방법
US20050177130A1 (en) * 2004-02-10 2005-08-11 Angioscore, Inc. Balloon catheter with spiral folds
US20050182479A1 (en) 2004-02-13 2005-08-18 Craig Bonsignore Connector members for stents
US7157492B2 (en) 2004-02-26 2007-01-02 Wyeth Dibenzo chromene derivatives and their use as ERβ selective ligands
US20050203410A1 (en) 2004-02-27 2005-09-15 Ep Medsystems, Inc. Methods and systems for ultrasound imaging of the heart from the pericardium
US7662114B2 (en) 2004-03-02 2010-02-16 Focus Surgery, Inc. Ultrasound phased arrays
US7198632B2 (en) 2004-03-02 2007-04-03 Boston Scientific Scimed, Inc. Occlusion balloon catheter with longitudinally expandable balloon
US8052636B2 (en) 2004-03-05 2011-11-08 Hansen Medical, Inc. Robotic catheter system and methods
US7247141B2 (en) 2004-03-08 2007-07-24 Ethicon Endo-Surgery, Inc. Intra-cavitary ultrasound medical system and method
US7238184B2 (en) 2004-03-15 2007-07-03 Boston Scientific Scimed, Inc. Ablation probe with peltier effect thermal control
US20060195139A1 (en) 2004-03-23 2006-08-31 Michael Gertner Extragastric devices and methods for gastroplasty
US9555223B2 (en) 2004-03-23 2017-01-31 Medtronic Cryocath Lp Method and apparatus for inflating and deflating balloon catheters
US20050228415A1 (en) 2004-03-23 2005-10-13 Michael Gertner Methods and devices for percutaneous, non-laparoscopic treatment of obesity
US7841978B2 (en) 2004-03-23 2010-11-30 Michael Gertner Methods and devices for to treatment of obesity
US20080147002A1 (en) 2004-03-23 2008-06-19 Michael Eric Gertner Obesity treatment systems
US20060142790A1 (en) 2004-03-23 2006-06-29 Michael Gertner Methods and devices to facilitate connections between body lumens
US20080300618A1 (en) 2004-03-23 2008-12-04 Michael Eric Gertner Obesity treatment systems
US8001976B2 (en) 2004-03-23 2011-08-23 Michael Gertner Management systems for the surgically treated obese patient
WO2006049725A2 (en) 2004-03-23 2006-05-11 Minimus Surgical Systems Surgical systems and devices to enhance gastric restriction therapies
US20080071306A1 (en) 2004-03-23 2008-03-20 Michael Gertner Extragastric Balloon With Attachment Tabs
US7946976B2 (en) 2004-03-23 2011-05-24 Michael Gertner Methods and devices for the surgical creation of satiety and biofeedback pathways
US20070233170A1 (en) 2004-03-23 2007-10-04 Michael Gertner Extragastric Balloon
US7255675B2 (en) 2004-03-23 2007-08-14 Michael Gertner Devices and methods to treat a patient
US8343031B2 (en) 2004-03-23 2013-01-01 Michael Gertner Obesity treatment systems
US7854733B2 (en) 2004-03-24 2010-12-21 Biosense Webster, Inc. Phased-array for tissue treatment
US20050214268A1 (en) 2004-03-25 2005-09-29 Cavanagh William A Iii Methods for treating tumors and cancerous tissues
US7323006B2 (en) 2004-03-30 2008-01-29 Xtent, Inc. Rapid exchange interventional devices and methods
JP4216810B2 (ja) 2004-03-30 2009-01-28 株式会社東芝 生体情報計測装置
US20060018949A1 (en) 2004-04-07 2006-01-26 Bausch & Lomb Incorporated Injectable biodegradable drug delivery system
US20050228286A1 (en) 2004-04-07 2005-10-13 Messerly Jeffrey D Medical system having a rotatable ultrasound source and a piercing tip
US7566319B2 (en) 2004-04-21 2009-07-28 Boston Scientific Scimed, Inc. Traction balloon
US20060004323A1 (en) 2004-04-21 2006-01-05 Exploramed Nc1, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US20050245862A1 (en) 2004-04-28 2005-11-03 Endobionics, Inc. Torque mechanism for interventional catheters
US20050251116A1 (en) 2004-05-05 2005-11-10 Minnow Medical, Llc Imaging and eccentric atherosclerotic material laser remodeling and/or ablation catheter
US7291142B2 (en) 2004-05-10 2007-11-06 Boston Scientific Scimed, Inc. Low temperature lesion formation apparatus, systems and methods
US7087053B2 (en) 2004-05-27 2006-08-08 St. Jude Medical, Atrial Fibrillation Division, Inc. Catheter with bifurcated, collapsible tip for sensing and ablating
US7527643B2 (en) 2004-05-28 2009-05-05 Cook Incorporated Exchangeable delivery system for expandable prosthetic devices
US20050267556A1 (en) 2004-05-28 2005-12-01 Allan Shuros Drug eluting implants to prevent cardiac apoptosis
EP1750607A2 (en) 2004-06-02 2007-02-14 Medtronic, Inc. Loop ablation apparatus and method
US20050273149A1 (en) 2004-06-08 2005-12-08 Tran Thomas T Bifurcated stent delivery system
US7640046B2 (en) 2004-06-18 2009-12-29 Cardiac Pacemakers, Inc. Methods and apparatuses for localizing myocardial infarction during catheterization
US7197354B2 (en) 2004-06-21 2007-03-27 Mediguide Ltd. System for determining the position and orientation of a catheter
US7367975B2 (en) 2004-06-21 2008-05-06 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US20060024564A1 (en) 2004-07-06 2006-02-02 Manclaw Ronald R Manclaw-Harrison fuel cell
WO2006015354A2 (en) 2004-07-30 2006-02-09 Washington University In St. Louis Electrosurgical systems and methods
US7799021B2 (en) 2004-08-04 2010-09-21 Kimberly-Clark Inc. Electrosurgical treatment in conjunction with monitoring
CN101123994B (zh) 2004-08-16 2012-11-14 夸克医药公司 Rtp801的抑制剂的治疗性用途
US7540852B2 (en) 2004-08-26 2009-06-02 Flowcardia, Inc. Ultrasound catheter devices and methods
AU2005282554A1 (en) 2004-09-07 2006-03-16 Wyeth 6H-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents
US20060095096A1 (en) 2004-09-09 2006-05-04 Debenedictis Leonard C Interchangeable tips for medical laser treatments and methods for using same
US20060085054A1 (en) 2004-09-09 2006-04-20 Zikorus Arthur W Methods and apparatus for treatment of hollow anatomical structures
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US8545488B2 (en) 2004-09-17 2013-10-01 The Spectranetics Corporation Cardiovascular imaging system
US7458971B2 (en) 2004-09-24 2008-12-02 Boston Scientific Scimed, Inc. RF ablation probe with unibody electrode element
US7635383B2 (en) 2004-09-28 2009-12-22 Boston Scientific Scimed, Inc. Rotating stent delivery system for side branch access and protection and method of using same
US20060069385A1 (en) 2004-09-28 2006-03-30 Scimed Life Systems, Inc. Methods and apparatus for tissue cryotherapy
WO2006042047A1 (en) 2004-10-07 2006-04-20 Flea Street Translational, Llc Methods, systems and devices for establishing communication between hollow organs and tissue lumens
US20060089637A1 (en) 2004-10-14 2006-04-27 Werneth Randell L Ablation catheter
US7887538B2 (en) 2005-10-15 2011-02-15 Baxano, Inc. Methods and apparatus for tissue modification
US7938830B2 (en) 2004-10-15 2011-05-10 Baxano, Inc. Powered tissue modification devices and methods
US7962854B2 (en) 2004-10-19 2011-06-14 Sony Ericsson Mobile Communications Ab Systems, methods and computer program products for displaying content on multiple display screens using handheld wireless communicators
US20060083194A1 (en) 2004-10-19 2006-04-20 Ardian Dhrimaj System and method rendering audio/image data on remote devices
US20060089638A1 (en) 2004-10-27 2006-04-27 Yuval Carmel Radio-frequency device for passivation of vascular plaque and method of using same
US7753907B2 (en) 2004-10-29 2010-07-13 Boston Scientific Scimed, Inc. Medical device systems and methods
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US7200445B1 (en) 2005-10-21 2007-04-03 Asthmatx, Inc. Energy delivery devices and methods
US20090240249A1 (en) 2004-11-08 2009-09-24 Cardima, Inc. System and Method for Performing Ablation and Other Medical Procedures Using An Electrode Array with Flexible Circuit
US8617152B2 (en) 2004-11-15 2013-12-31 Medtronic Ablation Frontiers Llc Ablation system with feedback
WO2006055845A1 (en) 2004-11-15 2006-05-26 Cytyc Corporation System for drug delivery
JP2008520331A (ja) 2004-11-18 2008-06-19 トランスファーマ メディカル リミテッド 薬剤の経皮的送達のためのマイクロチャネル形成とイオントフォレーシスの組合せ
US20060167106A1 (en) 2004-11-19 2006-07-27 Mei Zhang Compounds acting at the centrosome
US7473890B2 (en) 2004-11-23 2009-01-06 New York University Manipulation of objects in potential energy landscapes
US20060247266A1 (en) 2004-11-26 2006-11-02 Asahi Kasei Pharma Corporation Nitrogen-containing tricyclic compounds
US8048144B2 (en) 2004-11-30 2011-11-01 Scimed Life Systems, Inc. Prosthesis fixation device and method
WO2006063199A2 (en) 2004-12-09 2006-06-15 The Foundry, Inc. Aortic valve repair
US7402151B2 (en) 2004-12-17 2008-07-22 Biocardia, Inc. Steerable guide catheters and methods for their use
EP1836849A1 (en) 2004-12-23 2007-09-26 Telecom Italia S.p.A. Method and system for video telephone communications set up, related equipment and computer program product
US20080009927A1 (en) 2005-01-11 2008-01-10 Vilims Bradley D Combination Electrical Stimulating and Infusion Medical Device and Method
US8007440B2 (en) 2005-02-08 2011-08-30 Volcano Corporation Apparatus and methods for low-cost intravascular ultrasound imaging and for crossing severe vascular occlusions
US20060182873A1 (en) 2005-02-17 2006-08-17 Klisch Leo M Medical devices
US7828837B2 (en) 2005-02-17 2010-11-09 Khoury Medical Devices, LLC. Vascular endograft
EP2308495A1 (en) 2005-03-04 2011-04-13 Sucampo AG Method and composition for treating peripheral vascular diseases
US8801701B2 (en) 2005-03-09 2014-08-12 Sunnybrook Health Sciences Centre Method and apparatus for obtaining quantitative temperature measurements in prostate and other tissue undergoing thermal therapy treatment
US7759315B2 (en) 2005-03-09 2010-07-20 Csl Behring Ag Treatment of inflammatory conditions of the intestine
US7674256B2 (en) 2005-03-17 2010-03-09 Boston Scientific Scimed, Inc. Treating internal body tissue
EP1868663B1 (en) 2005-03-23 2011-11-16 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US7670337B2 (en) 2005-03-25 2010-03-02 Boston Scientific Scimed, Inc. Ablation probe having a plurality of arrays of electrodes
EP3045110B1 (en) 2005-03-28 2019-07-31 Vessix Vascular, Inc. Intraluminal electrical tissue characterization and tuned rf energy for selective treatment of atheroma and other target tissues
US20060224153A1 (en) 2005-04-05 2006-10-05 Fischell Robert E Catheter system for the treatment of atrial fibrillation
US7715912B2 (en) 2005-04-13 2010-05-11 Intelect Medical, Inc. System and method for providing a waveform for stimulating biological tissue
AU2006239877B2 (en) 2005-04-21 2012-11-01 Boston Scientific Scimed, Inc. Control methods and devices for energy delivery
US20060239921A1 (en) 2005-04-26 2006-10-26 Novadaq Technologies Inc. Real time vascular imaging during solid organ transplant
US20060247760A1 (en) 2005-04-29 2006-11-02 Medtronic Vascular, Inc. Methods and apparatus for treatment of aneurysms adjacent branch arteries
US7505816B2 (en) 2005-04-29 2009-03-17 Medtronic, Inc. Actively cooled external energy source, external charger, system of transcutaneous energy transfer, system of transcutaneous charging and method therefore
US7806871B2 (en) 2005-05-09 2010-10-05 Boston Scientific Scimed, Inc. Method and device for tissue removal and for delivery of a therapeutic agent or bulking agent
CA2611963A1 (en) 2005-05-10 2007-06-14 Michael Gertner Obesity treatment systems
US7942874B2 (en) 2005-05-12 2011-05-17 Aragon Surgical, Inc. Apparatus for tissue cauterization
US20080091193A1 (en) 2005-05-16 2008-04-17 James Kauphusman Irrigated ablation catheter having magnetic tip for magnetic field control and guidance
US20070248639A1 (en) 2005-05-20 2007-10-25 Omeros Corporation Cyclooxygenase inhibitor and calcium channel antagonist compositions and methods for use in urological procedures
US7767844B2 (en) 2005-05-23 2010-08-03 Atomic Energy Council Method for manufacturing diethylene triamine pentaacetic acid derivative
US8951225B2 (en) 2005-06-10 2015-02-10 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
US7584004B2 (en) 2005-06-13 2009-09-01 Cardiac Pacemakers, Inc. Vascularly stabilized peripheral nerve cuff assembly
AU2006262447A1 (en) 2005-06-20 2007-01-04 Medtronic Ablation Frontiers Llc Ablation catheter
US7717853B2 (en) 2005-06-24 2010-05-18 Henry Nita Methods and apparatus for intracranial ultrasound delivery
EP3434232A1 (en) 2005-06-29 2019-01-30 ZOLL Circulation, Inc. Devices, systems and methods for rapid endovascular cooling
US20070016274A1 (en) 2005-06-29 2007-01-18 Boveja Birinder R Gastrointestinal (GI) ablation for GI tumors or to provide therapy for obesity, motility disorders, G.E.R.D., or to induce weight loss
AU2006266149B2 (en) 2005-06-30 2012-04-12 Rox Medical, Inc. Devices, systems, and methods for creation of a peripherally located fistula
DE102005032755B4 (de) 2005-07-13 2014-09-04 Siemens Aktiengesellschaft System zur Durchführung und Überwachung minimal-invasiver Eingriffe
US20070016184A1 (en) 2005-07-14 2007-01-18 Ethicon Endo-Surgery, Inc. Medical-treatment electrode assembly and method for medical treatment
CN102225023B (zh) 2005-07-21 2014-04-02 泰科医疗集团有限合伙公司 治疗中空解剖结构的系统和方法
JP2009502302A (ja) 2005-07-25 2009-01-29 グロス，ヨシ 血管の電気刺激
AU2006272544B2 (en) 2005-07-26 2012-01-19 Rox Medical, Inc. Devices, systems, and methods for peripheral arteriovenous fistula creation
US7983751B2 (en) 2005-08-12 2011-07-19 Proteus Biomedical, Inc. Measuring conduction velocity using one or more satellite devices
US7591996B2 (en) 2005-08-17 2009-09-22 University Of Washington Ultrasound target vessel occlusion using microbubbles
EP1933777B1 (en) 2005-08-22 2017-06-14 Incept, LLC Flared stents and apparatus for using them
DE102005041601B4 (de) 2005-09-01 2010-07-08 Siemens Ag Ablationskatheter zum Setzen einer Läsion und Verfahren zur Herstellung eines Ablationskatheters
SG10201807556TA (en) 2005-09-09 2018-10-30 Ottawa Hospital Res Inst Interpenetrating Networks, and Related Methods and Compositions
US8140170B2 (en) 2005-09-12 2012-03-20 The Cleveland Clinic Foundation Method and apparatus for renal neuromodulation
US20070073151A1 (en) 2005-09-13 2007-03-29 General Electric Company Automated imaging and therapy system
US20070299043A1 (en) 2005-10-03 2007-12-27 Hunter William L Anti-scarring drug combinations and use thereof
WO2007041593A2 (en) 2005-10-03 2007-04-12 Combinatorx, Incorporated Anti-scarring drug combinations and use thereof
DE102005050344A1 (de) 2005-10-20 2007-05-03 Siemens Ag Kryokatheter zur Einführung in ein Körpergefäß sowie medizinische Untersuchungs- und Behandlungsvorrichtung
US20070093697A1 (en) 2005-10-21 2007-04-26 Theranova, Llc Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature
US8257338B2 (en) 2006-10-27 2012-09-04 Artenga, Inc. Medical microbubble generation
JP4702704B2 (ja) 2005-11-01 2011-06-15 有限会社日本エレクテル バルーンカテーテルシステム
US7901420B2 (en) 2005-11-02 2011-03-08 University Of Massachusetts Tissue clamp
US8052700B2 (en) 2005-11-02 2011-11-08 University Of Massachusetts Tissue clamp
US10716749B2 (en) 2005-11-03 2020-07-21 Palo Alto Investors Methods and compositions for treating a renal disease condition in a subject
JP5149191B2 (ja) 2005-11-09 2013-02-20 コリア ユニバーシティ インダストリアル アンド アカデミック コラボレイション ファウンデーション 身体組織の局所的アブレーションのためのｒｆ電極
US7766833B2 (en) 2005-11-23 2010-08-03 General Electric Company Ablation array having independently activated ablation elements
US7959627B2 (en) 2005-11-23 2011-06-14 Barrx Medical, Inc. Precision ablating device
US8190238B2 (en) 2005-12-09 2012-05-29 Hansen Medical, Inc. Robotic catheter system and methods
US7776967B2 (en) 2005-12-16 2010-08-17 Continental Ag Polyorganosiloxane composition for use in unsaturated elastomer, article made therefrom, and associated method
US20080108867A1 (en) 2005-12-22 2008-05-08 Gan Zhou Devices and Methods for Ultrasonic Imaging and Ablation
US8031927B2 (en) 2005-12-28 2011-10-04 The General Hospital Corporation Medical image processing
US7993334B2 (en) 2005-12-29 2011-08-09 Boston Scientific Scimed, Inc. Low-profile, expanding single needle ablation probe
US7896874B2 (en) 2005-12-29 2011-03-01 Boston Scientific Scimed, Inc. RF ablation probes with tine valves
US20070162109A1 (en) 2006-01-11 2007-07-12 Luis Davila Intraluminal stent graft
US8033284B2 (en) 2006-01-11 2011-10-11 Curaelase, Inc. Therapeutic laser treatment
CA2574935A1 (en) 2006-01-24 2007-07-24 Sherwood Services Ag A method and system for controlling an output of a radio-frequency medical generator having an impedance based control algorithm
EP2529761B1 (en) 2006-01-31 2017-06-14 Nanocopoeia, Inc. Nanoparticle coating of surfaces
US20070179496A1 (en) 2006-01-31 2007-08-02 Medtronic, Inc. Flexible catheter for ablation therapy
AU2007212587B2 (en) 2006-02-03 2012-07-12 Synecor, Llc Intravascular device for neuromodulation
US7918850B2 (en) 2006-02-17 2011-04-05 Biosense Wabster, Inc. Lesion assessment by pacing
US7869854B2 (en) 2006-02-23 2011-01-11 Magnetecs, Inc. Apparatus for magnetically deployable catheter with MOSFET sensor and method for mapping and ablation
US20070208210A1 (en) 2006-03-02 2007-09-06 G&L Consulting, Llc Method and apparatus to unload a failing heart
US8043673B2 (en) 2006-03-02 2011-10-25 Boston Scientific Scimed, Inc. Method to make tube-in-tube balloon
US20070208256A1 (en) 2006-03-03 2007-09-06 Medtronic Vascular, Inc. Multiple Branch Tubular Prosthesis and Methods
US8585753B2 (en) 2006-03-04 2013-11-19 John James Scanlon Fibrillated biodegradable prosthesis
US8027718B2 (en) 2006-03-07 2011-09-27 Mayo Foundation For Medical Education And Research Regional anesthetic
US7894905B2 (en) 2006-03-13 2011-02-22 Neuropace, Inc. Implantable system enabling responsive therapy for pain
US20070219576A1 (en) 2006-03-16 2007-09-20 Medtronic Vascular, Inc. Reversibly and Radially Expandable Electroactive Polymer Element for Temporary Occlusion of a Vessel
WO2007109171A2 (en) 2006-03-17 2007-09-27 Microcube, Llc Devices and methods for creating continuous lesions
US20070225781A1 (en) 2006-03-21 2007-09-27 Nidus Medical, Llc Apparatus and methods for altering temperature in a region within the body
EP2010085A1 (en) 2006-03-31 2009-01-07 Breval S.R.L. Device and method for the thermal ablation of tumors by means of high-frequency electromagnetic energy under overpressure conditions
US20080004673A1 (en) 2006-04-03 2008-01-03 Cvrx, Inc. Implantable extravascular electrostimulation system having a resilient cuff
CA2649119A1 (en) 2006-04-13 2007-12-13 Mirabilis Medica, Inc. Methods and apparatus for the treatment of menometrorrhagia, endometrial pathology, and cervical neoplasia using high intensity focused ultrasound energy
RU2008144957A (ru) 2006-04-14 2010-05-20 Конинклейке Филипс Электроникс, Н.В. (Nl) Системы и способы сердечной абляции с применением индуцированной с помощью лазера оптической деструкции (liob)
US20070244501A1 (en) 2006-04-18 2007-10-18 Horn Daniel J Medical balloons
US20080051454A1 (en) 2006-04-21 2008-02-28 The Board Of Trustees Operating Michigan State University Compositions and methods for transient receptor potential vanilloid (TRPV) channel mediated treatments
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
US7511494B2 (en) 2006-05-11 2009-03-31 The General Hospital Corporation Method for measuring the microarchitecture of complex tissue with MRI
CA2905086C (en) 2006-05-12 2021-03-30 Hira V. Thapliyal Device for ablating body tissue
US7725157B2 (en) 2006-05-16 2010-05-25 General Electric Company System and method for interventional procedures using MRI
WO2007135431A2 (en) 2006-05-24 2007-11-29 Emcision Limited Vessel sealing device and methods
WO2007140331A2 (en) 2006-05-25 2007-12-06 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
EP2024026B1 (en) 2006-06-02 2013-01-02 Neurostream Technologies General Partnership Nerve cuff and method for manufacturing same
WO2007141796A2 (en) 2006-06-09 2007-12-13 Quark Pharmaceuticals, Inc. Therapeutic uses of inhibitors of rtp801l
US20080097251A1 (en) 2006-06-15 2008-04-24 Eilaz Babaev Method and apparatus for treating vascular obstructions
JP2008010537A (ja) 2006-06-28 2008-01-17 Toshiba Corp Ｎａｎｄ型不揮発性半導体記憶装置およびｎａｎｄ型不揮発性半導体記憶装置の製造方法
ES2928065T3 (es) * 2006-06-28 2022-11-15 Medtronic Ardian Luxembourg Sistemas de neuromodulación renal inducida térmicamente
CA2552620C (en) 2006-07-20 2014-07-15 Ruggedcom Inc. An anchoring member to facilitate fastening daughter boards to a mother board and a method for use
GB0614557D0 (en) 2006-07-21 2006-08-30 Emcision Ltd Tissue Ablator
US8452988B2 (en) 2006-07-24 2013-05-28 Michael Sujue Wang Secure data storage for protecting digital content
CN101516286A (zh) 2006-07-28 2009-08-26 特偲芙医药公司 限制神经传导的切割装置和系统
WO2008017080A2 (en) 2006-08-03 2008-02-07 Hansen Medical, Inc. Systems for performing minimally invasive procedures
US20080039727A1 (en) 2006-08-08 2008-02-14 Eilaz Babaev Ablative Cardiac Catheter System
US20090221955A1 (en) 2006-08-08 2009-09-03 Bacoustics, Llc Ablative ultrasonic-cryogenic methods
US8725225B2 (en) 2006-08-10 2014-05-13 University Of Rochester Intraoperative imaging of renal cortical tumors and cysts
JP4790806B2 (ja) 2006-08-11 2011-10-12 株式会社日立国際電気 基板処理方法及び基板処理装置
WO2008022148A2 (en) 2006-08-14 2008-02-21 Stereotaxis, Inc. Method and apparatus for ablative recanalization of blocked vasculature
US20080243091A1 (en) 2006-08-22 2008-10-02 Mitchell R. Humphreys Process and System For Systematic Oxygenation and Renal Preservation During Retrograde Perfusion of the Ischemic Kidney
EP2057195A4 (en) 2006-08-29 2010-05-12 Forhumantech Co Ltd PHARMACEUTICAL COMPOSITION FOR THE SUPPRESSION OF APOPTOSIS AND METHOD OF ADMINISTERING THE SAME
US20080064957A1 (en) 2006-09-07 2008-03-13 Spence Paul A Ultrasonic implant, systems and methods related to diverting material in blood flow away from the head
US20080082109A1 (en) 2006-09-08 2008-04-03 Hansen Medical, Inc. Robotic surgical system with forward-oriented field of view guide instrument navigation
US8119183B2 (en) 2006-09-11 2012-02-21 Enbio Limited Method of doping surfaces
US8486060B2 (en) 2006-09-18 2013-07-16 Cytyc Corporation Power ramping during RF ablation
US20080071269A1 (en) 2006-09-18 2008-03-20 Cytyc Corporation Curved Endoscopic Medical Device
US7691080B2 (en) 2006-09-21 2010-04-06 Mercator Medsystems, Inc. Dual modulus balloon for interventional procedures
EP2267199A3 (en) 2006-09-29 2012-09-12 The University of Akron Metal oxide fibers and nanofibers, method for making same, and uses thereof
US8617149B2 (en) 2006-10-02 2013-12-31 Boston Scientific Scimed, Inc. Common bond, double-balloon catheter
US8641660B2 (en) 2006-10-04 2014-02-04 P Tech, Llc Methods and devices for controlling biologic microenvironments
US7664548B2 (en) 2006-10-06 2010-02-16 Cardiac Pacemakers, Inc. Distributed neuromodulation system for treatment of cardiovascular disease
WO2008049082A2 (en) 2006-10-18 2008-04-24 Minnow Medical, Inc. Inducing desirable temperature effects on body tissue
US8388680B2 (en) 2006-10-18 2013-03-05 Guided Delivery Systems, Inc. Methods and devices for catheter advancement and delivery of substances therethrough
WO2008049087A2 (en) 2006-10-18 2008-04-24 Minnow Medical, Inc. System for inducing desirable temperature effects on body tissue
CA2666661C (en) 2006-10-18 2015-01-20 Minnow Medical, Inc. Tuned rf energy and electrical tissue characterization for selective treatment of target tissues
US8088100B2 (en) 2006-10-20 2012-01-03 Boston Scientific Scimed, Inc. Reinforced rewrappable balloon
US7615072B2 (en) 2006-11-14 2009-11-10 Medtronic Vascular, Inc. Endoluminal prosthesis
US20080255550A1 (en) 2006-11-30 2008-10-16 Minos Medical Systems and methods for less invasive neutralization by ablation of tissue including the appendix and gall bladder
US20080140002A1 (en) 2006-12-06 2008-06-12 Kamal Ramzipoor System for delivery of biologically active substances with actuating three dimensional surface
US7699809B2 (en) 2006-12-14 2010-04-20 Urmey William F Catheter positioning system
US7846160B2 (en) 2006-12-21 2010-12-07 Cytyc Corporation Method and apparatus for sterilization
US20080208162A1 (en) 2007-02-26 2008-08-28 Joshi Ashok V Device and Method For Thermophoretic Fluid Delivery
US20080221448A1 (en) 2007-03-07 2008-09-11 Khuri-Yakub Butrus T Image-guided delivery of therapeutic tools duing minimally invasive surgeries and interventions
US8406877B2 (en) 2007-03-19 2013-03-26 Cardiac Pacemakers, Inc. Selective nerve stimulation with optionally closed-loop capabilities
US9486651B2 (en) 2007-03-30 2016-11-08 Koninklijke Philips N.V. MRI-guided HIFU marking to guide radiotherapy and other procedures
US8198611B2 (en) 2007-04-02 2012-06-12 Globalfoundries Inc. Laser beam formatting module and method for fabricating semiconductor dies using same
US9259233B2 (en) 2007-04-06 2016-02-16 Hologic, Inc. Method and device for distending a gynecological cavity
US8496653B2 (en) 2007-04-23 2013-07-30 Boston Scientific Scimed, Inc. Thrombus removal
US7495439B2 (en) 2007-04-27 2009-02-24 The General Hospital Corporation MRI method for reducing artifacts using RF pulse at offset frequency
US8641704B2 (en) 2007-05-11 2014-02-04 Medtronic Ablation Frontiers Llc Ablation therapy system and method for treating continuous atrial fibrillation
US11395694B2 (en) 2009-05-07 2022-07-26 St. Jude Medical, Llc Irrigated ablation catheter with multiple segmented ablation electrodes
US20080294037A1 (en) 2007-05-23 2008-11-27 Jacob Richter Apparatus and Method for Guided Chronic Total Occlusion Penetration
US20080312673A1 (en) 2007-06-05 2008-12-18 Viswanathan Raju R Method and apparatus for CTO crossing
US8263104B2 (en) 2007-06-08 2012-09-11 Northwestern University Polymer nanofilm coatings
US20090210953A1 (en) 2007-06-08 2009-08-20 Bryan Moyer Identification of TRPML3 (MCOLN3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone, and/or vasopressin production or release
US20080312644A1 (en) 2007-06-14 2008-12-18 Boston Scientific Scimed, Inc. Cryogenic balloon ablation instruments and systems
US20090270850A1 (en) 2007-06-20 2009-10-29 Tea Time Partners, L.P., Organized In Texas Devices and methods for the ablation of tissue in the lateral direction
US20090018486A1 (en) 2007-07-13 2009-01-15 Menachem Goren Diagnosis and treatment of vericocele and prostate disorders
US8828068B2 (en) 2007-07-17 2014-09-09 Cardiac Pacemakers, Inc. Systems and methods for local vasoactive response using temperature modulation
US8702609B2 (en) 2007-07-27 2014-04-22 Meridian Cardiovascular Systems, Inc. Image-guided intravascular therapy catheters
US8821477B2 (en) 2007-08-06 2014-09-02 Boston Scientific Scimed, Inc. Alternative micromachined structures
KR101282285B1 (ko) 2007-08-20 2013-07-10 삼성전자주식회사 이동 통신 시스템에서 위치 기반 서비스 제공 시스템 및방법
US8066731B2 (en) 2007-08-20 2011-11-29 Olympus Medical Systems Corp. Treatment device
US7863897B2 (en) 2007-09-07 2011-01-04 The General Hospital Corporation Method and apparatus for characterizing the temporal resolution of an imaging device
US20090069671A1 (en) 2007-09-10 2009-03-12 General Electric Company Electric Motor Tracking System and Method
US7777486B2 (en) 2007-09-13 2010-08-17 The Board Of Trustees Of The Leland Stanford Junior University Magnetic resonance imaging with bipolar multi-echo sequences
CN101854977B (zh) 2007-09-14 2015-09-09 拉热尔技术有限公司 前列腺癌消融
US9283034B2 (en) 2007-09-26 2016-03-15 Retrovascular, Inc. Recanalization system using radiofrequency energy
JP5479672B2 (ja) 2007-09-27 2014-04-23 シスメックス株式会社 血液または尿の分析装置およびデータ処理装置
US8308763B2 (en) 2007-10-05 2012-11-13 Coaptus Medical Corporation Systems and methods for transeptal cardiac procedures, including separable guidewires
WO2009055286A1 (en) 2007-10-24 2009-04-30 Edwards Lifesciences Corporation Percutaneous nitinol stent extraction device
WO2009055542A1 (en) 2007-10-26 2009-04-30 University Of Utah Research Foundation Use of mri contrast agents for evaluating the treatment of tumors
US20090112202A1 (en) 2007-10-31 2009-04-30 Boston Scientific Scimed, Inc. Dispersive electrode with thermochromatic properties
US20090118620A1 (en) 2007-11-06 2009-05-07 General Electric Company System and method for tracking an ultrasound catheter
US8613721B2 (en) 2007-11-14 2013-12-24 Medrad, Inc. Delivery and administration of compositions using interventional catheters
US20090131798A1 (en) 2007-11-19 2009-05-21 Minar Christopher D Method and apparatus for intravascular imaging and occlusion crossing
US20090143640A1 (en) 2007-11-26 2009-06-04 Voyage Medical, Inc. Combination imaging and treatment assemblies
EA201000865A1 (ru) 2007-11-30 2010-12-30 Новартис Аг Комбинация ингибиторов протеинтирозинфосфатазы и гормона роста человека, предназначенная для лечения атрофии мышц и родственных нарушений
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US8021413B2 (en) 2007-12-27 2011-09-20 Cook Medical Technologies Llc Low profile medical device
WO2009085666A1 (en) 2007-12-27 2009-07-09 Boston Scientific Scimed, Inc. System for controllably delivering liquid coolant to a cryo-ablation device
US8273023B2 (en) 2009-01-05 2012-09-25 Texas Heart Institute Introducer sheathe with electrodes
US8366615B2 (en) 2009-01-05 2013-02-05 Texas Heart Institute Introducer sheath with electrodes
GB2456301A (en) 2008-01-08 2009-07-15 Gmj Design Ltd Surface Representation from a Point Cloud
US8676322B2 (en) 2008-01-30 2014-03-18 Boston Scientific Neuromodulation Corporation Methods and systems of treating pancreatitis pain
JP5153892B2 (ja) 2008-02-07 2013-02-27 カーディアック ペースメイカーズ， インコーポレイテッド 無線組織電気刺激
US8858609B2 (en) 2008-02-07 2014-10-14 Intuitive Surgical Operations, Inc. Stent delivery under direct visualization
DE102008008925A1 (de) * 2008-02-13 2009-08-20 Biotronik Vi Patent Ag Katheter, System zum Einbringen einer intraluminalen Endoprothese sowie Verfahren zur Herstellung derselben
EP2259739B1 (en) 2008-02-19 2015-04-01 Boston Scientific Scimed, Inc. Apparatus for uniformly distributing coolant within a cryo-ablation device
US20110040324A1 (en) 2008-03-17 2011-02-17 Mccarthy Patrick M Devices and methods for percutaneous access, hemostasis, and closure
WO2009121009A2 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California Irreversible electroporation device for use in attenuating neointimal
US20090247966A1 (en) 2008-03-28 2009-10-01 Gunn Euen T Methods and products for applying structured compositions to a substrate
US20090253974A1 (en) 2008-04-08 2009-10-08 Marc Mounir Rahme Use of tools, mapping systems, catheters, electrodes or any devices targeting any autonomic nerve(s) structure(s) in the human heart for the diagnostic, treatment and/or prevention of the recurrence of cardiac arrhythmias.
US20090264755A1 (en) 2008-04-22 2009-10-22 National Taiwan University High-Intensity Ultrasonic Vessel Ablator Using Blood Flow Signal for Precise Positioning
US7956613B2 (en) 2008-05-02 2011-06-07 The General Hospital Corporation Method for imaging acoustically induced rotary saturation with a magnetic resonance imaging system
CA2723806C (en) 2008-05-09 2022-05-31 Innovative Pulmonary Solutions, Inc. Systems, assemblies, and methods for treating a bronchial tree
WO2009140066A1 (en) 2008-05-12 2009-11-19 Boston Scientific Scimed, Inc. Apparatus for chilling cryo-ablation coolant
JP5345678B2 (ja) 2008-05-15 2013-11-20 ボストン サイエンティフィック サイムド，インコーポレイテッド 組織をクライオジェニック・アブレーション処理し、クライオジェニック・アブレーション領域を調整する装置
US8128617B2 (en) 2008-05-27 2012-03-06 Boston Scientific Scimed, Inc. Electrical mapping and cryo ablating with a balloon catheter
US8187261B2 (en) 2008-05-29 2012-05-29 Boston Scientific Scimed, Inc. Regulating internal pressure of a cryotherapy balloon catheter
US20090318749A1 (en) 2008-06-19 2009-12-24 Craig Stolen Method and apparatus for pacing and intermittent ischemia
US20100049099A1 (en) 2008-07-18 2010-02-25 Vytronus, Inc. Method and system for positioning an energy source
US20100030061A1 (en) 2008-07-31 2010-02-04 Canfield Monte R Navigation system for cardiac therapies using gating
US9597145B2 (en) 2008-08-20 2017-03-21 Prostacare Pty Ltd Non-thermal ablation system for treating tissue
WO2010022314A1 (en) 2008-08-21 2010-02-25 Med-El Elektromedizinische Geraete Gmbh Multipath stimulation hearing systems
WO2010022367A2 (en) 2008-08-21 2010-02-25 Bliss Holdings, Llc Illumination-based medical device and methods of use thereof
US20100069837A1 (en) 2008-09-16 2010-03-18 Boston Scientific Scimed, Inc. Balloon Assembly and Method for Therapeutic Agent Delivery
JP5622729B2 (ja) 2008-09-22 2014-11-12 べシックス・バスキュラー・インコーポレイテッド 身体組織に対して温度効果を誘発するシステム
DE102008048616B4 (de) 2008-09-23 2010-08-05 Olympus Winter & Ibe Gmbh Urologischer Ballonkatheter
DE102008050347B4 (de) 2008-10-02 2011-01-20 Siemens Aktiengesellschaft Verfahren, Magnetresonanzanlage und Datenträger zur Bestimmung eines Nierenfunktionsparameters
WO2010042653A1 (en) 2008-10-07 2010-04-15 Mc10, Inc. Catheter balloon having stretchable integrated circuitry and sensor array
US8372068B2 (en) 2008-10-21 2013-02-12 Hermes Innovations, LLC Tissue ablation systems
US20100114244A1 (en) 2008-10-31 2010-05-06 Medtronic, Inc. Electrical renal autonomic blockade
PL2370015T3 (pl) * 2008-11-11 2017-07-31 Shifamed Holdings, Llc Niskoprofilowy zespół elektrodowy
US8805466B2 (en) * 2008-11-11 2014-08-12 Shifamed Holdings, Llc Low profile electrode assembly
US9468364B2 (en) 2008-11-14 2016-10-18 Intuitive Surgical Operations, Inc. Intravascular catheter with hood and image processing systems
WO2010056745A1 (en) 2008-11-17 2010-05-20 Minnow Medical, Inc. Selective accumulation of energy with or without knowledge of tissue topography
EP2376189B1 (en) 2008-12-09 2018-02-07 Nephera Ltd. Stimulation of the urinary system
JP5694947B2 (ja) 2008-12-11 2015-04-01 エムシー１０ インコーポレイテッドＭｃ１０，Ｉｎｃ． 医療用途のための伸張性電子部品を使用する装置
US20100160903A1 (en) 2008-12-22 2010-06-24 Yosef Krespi Process and system for treating a vascular occlusion or other endoluminal structure
US20100160906A1 (en) 2008-12-23 2010-06-24 Asthmatx, Inc. Expandable energy delivery devices having flexible conductive elements and associated systems and methods
US8317810B2 (en) 2008-12-29 2012-11-27 St. Jude Medical, Atrial Fibrillation Division, Inc. Tissue puncture assemblies and methods for puncturing tissue
US9352174B2 (en) 2008-12-30 2016-05-31 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation system with blood leakage minimization and tissue protective capabilities
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8808345B2 (en) 2008-12-31 2014-08-19 Medtronic Ardian Luxembourg S.A.R.L. Handle assemblies for intravascular treatment devices and associated systems and methods
US20100168739A1 (en) 2008-12-31 2010-07-01 Ardian, Inc. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
EP2208506A1 (en) 2009-01-16 2010-07-21 Oncotherm Kft. Intraluminar oncothermia catheter
US20100191232A1 (en) 2009-01-27 2010-07-29 Boveda Marco Medical Llc Catheters and methods for performing electrophysiological interventions
WO2010102310A2 (en) 2009-03-03 2010-09-10 Mc10, Inc. Systems, methods, and devices having stretchable integrated circuitry for sensing and delivering therapy
US20100249604A1 (en) 2009-03-31 2010-09-30 Boston Scientific Corporation Systems and methods for making and using a motor distally-positioned within a catheter of an intravascular ultrasound imaging system
US8287532B2 (en) 2009-04-13 2012-10-16 Biosense Webster, Inc. Epicardial mapping and ablation catheter
WO2010123931A1 (en) 2009-04-20 2010-10-28 Calistoga Pharmaceuticals Inc. Methods of treatment for solid tumors
EP3158866A3 (en) 2009-04-22 2017-07-26 Mercator Medsystems, Inc. Use of neuromodulating agents for treating hypertension by local vascular delivery
US8517955B2 (en) 2009-05-08 2013-08-27 Broncus Medical Inc. Tissue sampling devices, systems and methods
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
US8292881B2 (en) 2009-05-27 2012-10-23 Vivant Medical, Inc. Narrow gauge high strength choked wet tip microwave ablation antenna
EP2451422B1 (en) 2009-07-08 2016-10-12 Sanuwave, Inc. Usage of extracorporeal and intracorporeal pressure shock waves in medicine
WO2011005901A2 (en) 2009-07-09 2011-01-13 Silhouette Medical Inc. Apparatus for treating medical conditions of hollow anatomical structures
US20110071400A1 (en) 2009-09-23 2011-03-24 Boston Scientific Scimed, Inc. Systems and methods for making and using intravascular ultrasound imaging systems with sealed imaging cores
US20110071401A1 (en) 2009-09-24 2011-03-24 Boston Scientific Scimed, Inc. Systems and methods for making and using a stepper motor for an intravascular ultrasound imaging system
US8343145B2 (en) 2009-09-28 2013-01-01 Vivant Medical, Inc. Microwave surface ablation using conical probe
US9101733B2 (en) 2009-09-29 2015-08-11 Biosense Webster, Inc. Catheter with biased planar deflection
US8295912B2 (en) 2009-10-12 2012-10-23 Kona Medical, Inc. Method and system to inhibit a function of a nerve traveling with an artery
US20110118600A1 (en) 2009-11-16 2011-05-19 Michael Gertner External Autonomic Modulation
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
US20110092880A1 (en) 2009-10-12 2011-04-21 Michael Gertner Energetic modulation of nerves
CN102596319B (zh) 2009-10-30 2015-07-15 科纳医药股份有限公司 通过去肾交感神经非侵入性地治疗高血压的装置
EP2995350B1 (en) 2009-10-30 2016-08-03 ReCor Medical, Inc. Apparatus for treatment of hypertension through percutaneous ultrasound renal denervation
US20110112400A1 (en) 2009-11-06 2011-05-12 Ardian, Inc. High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation
CA2781951A1 (en) 2009-11-13 2011-05-19 St. Jude Medical, Inc. Assembly of staggered ablation elements
US20110137155A1 (en) 2009-12-09 2011-06-09 Boston Scientific Scimed, Inc. Delivery device for localized delivery of a therapeutic agent
US9179827B2 (en) 2009-12-15 2015-11-10 Boston Scientific Scimed, Inc. Systems and methods for determining the position and orientation of medical devices inserted into a patient
US20110263921A1 (en) 2009-12-31 2011-10-27 Anthony Vrba Patterned Denervation Therapy for Innervated Renal Vasculature
US20110264116A1 (en) 2009-12-31 2011-10-27 Gordon Kocur Compressive Denervation Apparatus for Innervated Renal Vasculature
US20110270238A1 (en) 2009-12-31 2011-11-03 Raed Rizq Compliant Cryoballoon Apparatus for Denervating Ostia of the Renal Arteries
EP2525715A4 (en) 2010-01-19 2014-06-04 Medtronic Ardian Luxembourg S R L METHODS AND APPARATUS FOR RENAL NEUROMODULATION BY STEREOTACTIC RADIOTHERAPY
WO2011119857A2 (en) 2010-03-24 2011-09-29 Shifamed, Llc Intravascular tissue disruption
JP2013523318A (ja) 2010-04-09 2013-06-17 べシックス・バスキュラー・インコーポレイテッド 組織の治療のための発電および制御の装置
US20110257641A1 (en) 2010-04-14 2011-10-20 Roger Hastings Phototherapy for renal denervation
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
CN102933169B (zh) 2010-04-14 2016-03-16 波士顿科学西美德公司 采用螺旋成形装置的肾动脉去神经支配术器械
US20110257642A1 (en) 2010-04-16 2011-10-20 Griggs Iii Charles Sherman Method for producing a permanent or nearly permanent skin image, design or tattoo by freezing the skin
US8870863B2 (en) 2010-04-26 2014-10-28 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US8120518B2 (en) 2010-06-14 2012-02-21 Koren Advanced Institute of Science and Technology Digital feedforward sigma-delta modulator in analog-to-digital converter and modulation method thereof
US9358020B2 (en) 2010-06-25 2016-06-07 Boston Scientific Scimed Inc. Catheter device for delivery energy to a vein
US20120029496A1 (en) 2010-07-30 2012-02-02 Scott Smith Renal nerve ablation using mild freezing and microwave energy
US20120029512A1 (en) 2010-07-30 2012-02-02 Willard Martin R Balloon with surface electrodes and integral cooling for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US20120029505A1 (en) 2010-07-30 2012-02-02 Jenson Mark L Self-Leveling Electrode Sets for Renal Nerve Ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
CN107349009B (zh) 2010-08-05 2020-06-26 美敦力Af卢森堡有限责任公司 用于肾神经调制的低温消融装置、系统及方法
US20120059286A1 (en) 2010-09-07 2012-03-08 Roger Hastings Self-Powered Ablation Catheter for Renal Denervation
US20120059241A1 (en) 2010-09-08 2012-03-08 Boston Scientific Scimed, Inc. Systems and methods for making and using a steerable imaging system configured and arranged for insertion into a patient
US20120065554A1 (en) 2010-09-09 2012-03-15 Michael Pikus Dual Balloon Ablation Catheter with Vessel Deformation Arrangement for Renal Nerve Ablation
US20120065506A1 (en) 2010-09-10 2012-03-15 Scott Smith Mechanical, Electromechanical, and/or Elastographic Assessment for Renal Nerve Ablation
ES2751156T3 (es) 2010-10-20 2020-03-30 Medtronic Ardian Luxembourg Aparatos de catéter que tienen estructuras de malla expansibles para neuromodulación renal
TWI556849B (zh) 2010-10-21 2016-11-11 美敦力阿福盧森堡公司 用於腎臟神經協調的導管裝置
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
TW201221174A (en) 2010-10-25 2012-06-01 Medtronic Ardian Luxembourg Microwave catheter apparatuses, systems, and methods for renal neuromodulation
US9066720B2 (en) 2010-10-25 2015-06-30 Medtronic Ardian Luxembourg S.A.R.L. Devices, systems and methods for evaluation and feedback of neuromodulation treatment
EP2632378B1 (en) 2010-10-25 2018-10-17 Medtronic Ardian Luxembourg S.à.r.l. Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems
US20120158104A1 (en) 2010-10-26 2012-06-21 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9060754B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US20120109021A1 (en) 2010-10-27 2012-05-03 Roger Hastings Renal denervation catheter employing acoustic wave generator arrangement
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US20120123261A1 (en) 2010-11-16 2012-05-17 Jenson Mark L Renal Nerve Ablation Using Mild Freezing and Vibration
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US20120265198A1 (en) 2010-11-19 2012-10-18 Crow Loren M Renal nerve detection and ablation apparatus and method
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US20120136349A1 (en) 2010-11-30 2012-05-31 Roger Hastings RENAL DENERVATION CATHETER AND METHOD USING pH ALTERATION
US20120157992A1 (en) 2010-12-15 2012-06-21 Scott Smith Off-wall electrode device for renal nerve ablation
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
US20120232409A1 (en) 2010-12-15 2012-09-13 Stahmann Jeffrey E System and method for renal artery occlusion during renal denervation therapy
US9220561B2 (en) 2011-01-19 2015-12-29 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
US20120184952A1 (en) 2011-01-19 2012-07-19 Jenson Mark L Low-profile off-wall electrode device for renal nerve ablation
WO2013013156A2 (en) 2011-07-20 2013-01-24 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
EP2734264B1 (en) 2011-07-22 2018-11-21 Boston Scientific Scimed, Inc. Nerve modulation system with a nerve modulation element positionable in a helical guide
US20130035681A1 (en) 2011-08-04 2013-02-07 Boston Scientific Scimed, Inc. Novel catheter for contiguous rf ablation
US8702619B2 (en) 2011-08-26 2014-04-22 Symap Holding Limited Mapping sympathetic nerve distribution for renal ablation and catheters for same
US9427579B2 (en) 2011-09-29 2016-08-30 Pacesetter, Inc. System and method for performing renal denervation verification
US20140243821A1 (en) 2011-09-30 2014-08-28 Covidien Lp Energy delivery device and methods of use
WO2013055826A1 (en) 2011-10-10 2013-04-18 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
US20130090578A1 (en) 2011-10-10 2013-04-11 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
US10085799B2 (en) 2011-10-11 2018-10-02 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US20130090649A1 (en) 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
US20130090650A1 (en) 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Renal nerve ablation cooling device and technique
CN103857353B (zh) 2011-10-11 2017-03-01 波士顿科学西美德公司 具有绝缘尖端的消融导管
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
US20130096550A1 (en) 2011-10-18 2013-04-18 Boston Scientific Scimed, Inc. Ablative catheter with electrode cooling and related methods of use
US9079000B2 (en) 2011-10-18 2015-07-14 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
US9162046B2 (en) 2011-10-18 2015-10-20 Boston Scientific Scimed, Inc. Deflectable medical devices
US20130110106A1 (en) 2011-10-28 2013-05-02 Boston Scientific Scimed, Inc. Expandable structure for off-wall ablation electrode
CN108095821B (zh) * 2011-11-08 2021-05-25 波士顿科学西美德公司 孔部肾神经消融
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
AU2012358143B2 (en) 2011-12-23 2015-06-11 Boston Scientific Scimed, Inc. Expandable balloon or an electrode pad with a heat sensing device
US9433760B2 (en) 2011-12-28 2016-09-06 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US20130172877A1 (en) * 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Balloon expandable multi-electrode rf ablation catheter
US20130172880A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods for renal nerve modulation
US20130172879A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Renal nerve modulation medical devices
WO2013101485A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
CN104768487A (zh) 2012-09-13 2015-07-08 波士顿科学西美德公司 肾脏神经调节球囊及其制造和使用方法
CN203017080U (zh) 2012-11-21 2013-06-26 湖南爱芷生医疗科技有限公司 用于直肠癌的深低温治疗机

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6142993A (en) * 1998-02-27 2000-11-07 Ep Technologies, Inc. Collapsible spline structure using a balloon as an expanding actuator
CN202723978U (zh) * 2012-02-02 2013-02-13 北京中孵友信医药科技股份有限公司 一种用于特殊治疗的腔内导管
CN103027750A (zh) * 2012-11-23 2013-04-10 刘宗军 一种经皮肾动脉内电消融球囊射频导管
CN203017083U (zh) * 2012-12-31 2013-06-26 上海微创电生理医疗科技有限公司 多电极消融导管

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