US20070066972A1 - Ablation catheter apparatus with one or more electrodes - Google Patents
Ablation catheter apparatus with one or more electrodes Download PDFInfo
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- US20070066972A1 US20070066972A1 US11/551,162 US55116206A US2007066972A1 US 20070066972 A1 US20070066972 A1 US 20070066972A1 US 55116206 A US55116206 A US 55116206A US 2007066972 A1 US2007066972 A1 US 2007066972A1
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- end portion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00292—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
- A61B2017/003—Steerable
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00839—Bioelectrical parameters, e.g. ECG, EEG
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/0091—Handpieces of the surgical instrument or device
- A61B2018/00916—Handpieces of the surgical instrument or device with means for switching or controlling the main function of the instrument or device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/0091—Handpieces of the surgical instrument or device
- A61B2018/00916—Handpieces of the surgical instrument or device with means for switching or controlling the main function of the instrument or device
- A61B2018/0094—Types of switches or controllers
- A61B2018/00946—Types of switches or controllers slidable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
- A61B2018/183—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves characterised by the type of antenna
Definitions
- the present invention generally relates to medical devices used for ablation of biological tissues, and more particularly to an ablation catheter apparatus incorporating one or more electrodes such as electrocardiogram (ECG) electrodes.
- ECG electrocardiogram
- Ablation catheters apply energy to a biological tissue site which requires ablation. Such catheters may use various energy modes, such as radiofrequency, ultrasound, laser, cryogenic, and the like.
- Radio frequency (“RF”) ablation catheters generally operate in the microwave frequency range and are used to destroy or ablate biological tissues for therapeutic purposes.
- microwave ablation catheters are used to ablate cardiac tissues that cause irregular heartbeats or arrhythmia, avoiding the need for more risky and invasive open heart surgery.
- the catheter-antenna is passed through the vein for access to the atrium. Within the atrium, the antenna is positioned at the desired location where ablation is required.
- An intracardiac electrogram is used to identify conductive pathways at the cardiac tissue site that needs to be ablated.
- Prior art ablation catheters have been equipped with two or more electrocardiogram (“ECG”) electrode rings or buttons made of electrically conductive material to provide the necessary output signal for identification of the desired ablation site.
- ECG electrocardiogram
- all catheters used for this purpose are installed with metallic electrodes, regardless of energy mode (RF, ultrasound, laser, cryogenic, or the like).
- Installing metallic electrodes over a microwave antenna has special challenges. Naked metallic electrodes installed wrongly can absorb ablation energy and become hot. Hot electrodes can have adverse effects on the heart or other biological tissues or organs, such as blood clot formation, adherence to tissue, and tissue charring. Naked metallic electrodes can also impede efficient delivery of energy and hinder ablation efficiency. Additionally, metallic electrodes can separate from the catheter when it is bent, resulting in inaccurate or lost signals.
- the ablation catheter system of this invention comprises an elongate catheter adapted for insertion into a body vessel of a patient, the catheter having a distal end portion adapted for positioning adjacent a biological tissue site requiring treatment and a proximal end portion having a connector for connection to a control unit for controlling the ablation procedure, an antenna disposed at the distal end portion of the catheter for providing output energy for tissue ablation purposes, a pair of conductors extending through the catheter from the proximal end portion and connected to the antenna for providing power to the antenna from a power supply in the control unit, and at least one electrode formed of a flexible conductive material disposed at the distal end portion of the antenna and connected to the connector at the proximal end portion of the catheter for providing an output signal to the control unit.
- the flexible conductive material is at least substantially non-metallic.
- Electrodes may be disposed at the distal end portion of the catheter.
- the electrode or electrodes are of conductive polymer material with hydrophilic characteristics for improved wetability.
- Two spaced electrode rings are mounted on or embedded in the outer surface of the cathode.
- one electrode ring may be provided and the other electrode may be a tip of conductive polymer material at the distal end of the catheter.
- layers of conductive and nonconductive polymer material may be provided at specific positions at the distal end portion of the catheter to produce multiple working electrodes.
- the electrode output signal can be connected to a suitable electrode recording system inputs in the control unit or a separate electrocardiogram unit to provide intracardiac signal mapping.
- This arrangement avoids the problems of metallic electrodes and also provides electrodes which are of a flexible polymer material which can bend readily with the distal end portion of the catheter as it is shaped or bent to negotiate a path through a body vessel.
- FIGS. 1A and 1B are side elevation views of a shapeable RF ablation catheter according to one embodiment in a straight and bent configuration, respectively;
- FIGS. 2A and 2B are side elevation views of a shapeable RF ablation catheter according to another embodiment with a different steering mechanism from FIG. 1 ;
- FIGS. 3A and 3B are cross sectional views of the distal end portion of the tip of the catheter of FIG. 1 or 2 in a straight configuration and a bent configuration, respectively;
- FIG. 4 is a cross-sectional view of the tip or distal end portion of one embodiment of a shapeable or bendable RF ablation catheter incorporating electrodes;
- FIG. 5 is a cross-sectional view of the tip or distal end portion of a shapeable or bendable RF ablation catheter having a modified electrode arrangement according to another embodiment
- FIG. 6 is a cross-sectional view of the tip or distal end portion of a shapeable or bendable RF ablation catheter with another electrode arrangement
- FIG. 7 is a cross-sectional view of the tip or distal end portion of a shapeable or bendable RF ablation catheter with a modified electrode arrangement according to another embodiment.
- FIG. 8 is a cross-sectional view of the tip or distal end portion of a shapeable or bendable RF ablation catheter with modified electrodes according to another embodiment.
- Certain embodiments as disclosed herein provide for systems and methods for ablation of biological tissues in body areas such as the heart, liver, and the like using a bendable radio-frequency (RF) catheter.
- the catheter is provided with electrodes of a flexible conductive material such as a conductive polymer at its distal end for providing an output signal such as an intracardiac electrocardiogram (“ECG”) signal to a control unit to allow physicians to obtain tissue proximity and electrical conductivity information both before and after tissue ablation, as well as to provide other feedback during the ablation procedure.
- ECG intracardiac electrocardiogram
- FIGS. 1A and 1B illustrate a radio-frequency (“RF”) ablation catheter system 100 of one embodiment including a shapeable catheter device 100 adapted for insertion into a body vessel of a patient and incorporating an RF antenna for delivering electromagnetic energy to a treatment site, as described in more detail below.
- RF radio-frequency
- the catheter device 100 has a flexible, elongated tubular body 120 having a proximal portion 130 and a distal or tip portion 140 .
- a handle chassis 160 Located at the proximal portion of the body is a handle chassis 160 containing steering and positioning controls (not illustrated) for the body, activated by actuator 200 .
- the tip portion of the catheter body is activated to bend between the straight configuration of FIG. 1A and the bent configuration of FIG. 1B by sliding the actuator back and forth in an axial direction.
- the tip portion is bent between the straight and bent configurations by rotating the actuator or collar 220 .
- Suitable mechanisms for controlling bending of the tip portion of catheter body 120 are described in detail in U.S. Pat. No. 7,004,938 of Ormsby et al., the contents of which are incorporated herein by reference. However, it will be understood that any suitable mechanism may be incorporated in the catheter device in order to control the bending or steering of the tip portion as it moves through a body vessel, organ, or cavity.
- a coupling or electrical connector 170 is provided at the proximal end of the catheter device for connecting the catheter to a control unit or the like containing one or more electronic devices such as an RF generator and controller (not shown) for providing power to the antenna during an ablation procedure.
- a control unit or the like containing one or more electronic devices such as an RF generator and controller (not shown) for providing power to the antenna during an ablation procedure.
- Suitable signal control units are known in the ablation catheter field and are therefore not described in detail here.
- the dimensions of the catheter body are adapted as required to suit the particular medical procedure, as is well known in the medical art.
- the catheter is used to ablate cardiac tissue.
- the catheter may be used to ablate other types of body tissue in different organs, both internal and external to the body.
- the tubular body 120 of the catheter device may be generally constructed of a polymer material which is bio-compatible with the body vessel environment. Examples of such materials include thermoplastic elastomer material such as Pebaxg available from Autochem Germany, polyethylene, polyurethane, polyester, polyimide, polyamide, and the like, with varying degrees of radiopacity, hardness, and elasticity.
- the tubular body of the catheter may be formed with a plurality of segments using one or more of the aforementioned materials or equivalents, such that the catheter body 120 is progressively more flexible towards its distal end.
- the segments may be joined together by thermal bonding, butt joints, or adhesive bonding.
- Braiding reinforcement may be provided to the surface of the tubular body to attain a desirable level of stiffness and torsional strength for the catheter to advance and negotiate through the body vessel of the patient, while still allowing the distal end portion to be bent when needed.
- the distal end portion 140 may be of a softer polymer compound than the remainder of the body, with little or no braiding or reinforcement, to provide the desired flexibility for distal deflection and shaping of the apparatus.
- the catheter has a tubular body with a central bore 150 and a closed distal end or tip.
- the tip may be open in alternative embodiments.
- deflection of the distal end portion of the catheter is accomplished by use of a pre-shaped deflection member 180 which is constrained in a straight orientation in the configuration of FIG. 3A and which adopts a bent shape when extended into the bent configuration of FIG. 3B .
- a pre-shaped deflection member 180 which is constrained in a straight orientation in the configuration of FIG. 3A and which adopts a bent shape when extended into the bent configuration of FIG. 3B .
- other bending or shaping mechanisms may be used in alternative embodiments, as described, for example, in U.S. Pat. No. 7,004,938 referenced above.
- the distal end portion 140 of the tubular body includes an RF antenna 250 comprising a flexible, helically coiled radiating antenna device 255 embedded in the flexible wall of the tubular body, as best illustrated in FIGS. 3A and 3B .
- the antenna device can therefore bend as the distal end portion is shaped to conform to a body vessel or the like, as illustrated in FIG. 3B .
- Opposite ends of the antenna device are connected to electrical conductors or leads for connection to the proximal end connector 170 and thereby to a source of RF energy in the catheter control unit (not illustrated), as will be described in more detail below in connection with FIG. 4 .
- Other antenna devices may be provided in alternative embodiments, and the diameter, pitch and length of the coiled device 255 , and the conductive material used for the device 255 , may vary according to the particular procedure and flexibility requirements.
- the electrical conductors which connect the RF antenna to the connector 170 may be of a flexible mesh or braided wire construction 260 or of a thin-film electrically conductive material.
- the conductors are shown schematically as a mesh construction embedded in the walls of the tubular body 120 of the catheter. In alternative arrangements, separate conductors may be used to provide power to the antenna 250 .
- FIG. 4 illustrates the distal end portion 310 of a first embodiment of a modified catheter having integrated electrodes 312 , 314 .
- the electrodes are ECG electrodes, although they may be other types of electrodes in other embodiments. Although two electrodes are illustrated in FIG.
- a pair of coaxial inner and outer tubular conductors 315 , 316 extend along the length of the tubular body 318 , with the outer conductor 316 connected to the proximal end of RF antenna 250 and the inner conductor 315 connected to the distal end of the RF antenna adjacent the tip of the catheter.
- the structure of the remainder of the tubular body 318 which is not shown in FIG.
- FIG. 4 may be identical to that of tubular body 120 described above, and a similar connector 170 (not illustrated) may be provided at the proximal end of the catheter for connecting the conductors to a suitable RF source.
- the distal end portion illustrated in FIG. 4 will be shapeable or bendable in a similar manner and using the same or similar control devices as were described above in connection with FIGS. 1 to 3 .
- the tubular body 318 is of dielectric material such as a non-conductive polymer and has a portion 320 of reduced outer diameter at its forward end.
- the first electrode 312 comprises a sleeve of flexible conductive material mounted over the reduced diameter end portion 320 of the tubular body and having an end portion or tip 322 extending over the open end of portion 320 .
- the RF or microwave antenna 250 is embedded in the sleeve or electrode 312 .
- the inner and outer conductors 315 , 316 extend through the tubular body 318 as illustrated for connection to the opposite ends of the antenna coil 250 .
- the second electrode 314 comprises a ring of flexible conductive material mounted over the tubular body 318 at a location spaced rearwardly from the rear end of conductive sleeve or electrode 312 .
- the two electrodes may be secured over the inner tubular body 318 by adhesive, bonding, mechanical force, heat sealing or the like.
- the flexible conductive material forming the electrodes is at least substantially non-metallic material and may be a conductive polymer material which is sufficiently bendable to allow bending of the distal end portion 310 between the positions illustrated in FIGS. 1A and 1B .
- the electrode ring 314 may be mounted flush in an annular recess or gap in the outer surface of the tubular body, or may be molded integrally with the tubular body, so that it does not project outwardly from the outer surface of the body 318 .
- a conductor or connector 324 extends from electrode ring 314 to the connector 170 at the proximal end of the catheter, for suitable connection to an ECG monitor or the like in a control unit (not illustrated) for the catheter.
- Conductor 324 is shown spaced from the outer surface of body 318 in FIG.
- both electrodes are of a flexible, conductive polymer material, i.e. a polymer material loaded with conductive materials.
- FIG. 5 illustrates the distal end portion 325 of a catheter with a modified electrode arrangement in which the electrode ring 314 of FIG. 4 is replaced by an electrode end cap 330 .
- Electrodes 312 , 330 are of flexible conductive material such as a conductive polymer material as in FIG. 4 .
- the conductive sleeve 312 in which the antenna is mounted has an outer cover layer 332 of non-conductive polymer material extending along at least part of its length and over its distal end, providing a non-conductive shield layer between the first and second electrodes 312 , 330 .
- a conductor or connector wire 334 extends from the connector at the proximal end of the catheter through the central lumen 150 of the tubular body 318 and into the electrode end cap 330 to provide a signal path between the electrode and the ECG monitor.
- the catheter of FIG. 5 is otherwise identical to that of the previous embodiment and like reference numerals have been used as appropriate.
- Conductive sleeve 312 , non-conductive layer 332 , and end cap 330 may be laminated together over the tubular body 318 by any suitable means such as bonding, heat sealing, adhesive, or the like.
- FIG. 6 illustrates the distal end portion 340 of a catheter having another modified electrode arrangement.
- Parts of the cathode of this embodiment are identical to those of FIGS. 4 and 5 and like reference numerals have been used for like parts as appropriate.
- the sleeve 335 in which the antenna coil 250 is embedded does not comprise one of the two electrodes.
- sleeve 335 is mounted over the reduced diameter end portion 320 of the tubular body 318 , which is of dielectric or non-conductive material, and the antenna coil 250 is connected at its opposite ends to the distal ends of the inner and outer conductors 315 , 316 .
- an outer layer 336 of non-conductive material extends over the conductive sleeve 335 and has an end cap portion 338 extending over the tip of the tubular body 318 .
- the electrodes in this embodiment comprise a pair of conductive rings 339 , 341 mounted at spaced intervals on the outer, non-conductive layer 336 .
- the ring electrodes may be of conductive polymer material.
- the first ring 339 is positioned adjacent the non-conductive end cap portion 338 and the second ring 341 is positioned adjacent the rear end of the conductive layer 336 .
- a central conductor or connector wire 342 extends through the hollow central bore or lumen of the tubular body 318 , through the non-conductive end cap portion 338 , and bends back to terminate in the first conductive ring electrode 339 .
- the part of connector wire 342 shown extending through lumen 150 may be a line of conductive ink or adhesive on the inner surface of tubular body 318 .
- a second conductor or connector wire 343 extends along the outside of the tubular body 318 and is connected to the second conductive ring electrode 341 .
- the connector wire 343 may comprise a line of conductive ink or adhesive on tubular body 318 , or may alternatively be embedded in the tubular body 318 at location spaced outside the outer tubular conductor 316 .
- the various conductive and non-conductive polymer layers of the distal end portion 340 , including the electrode rings, are suitably laminated together by heat sealing, adhesive bonding, or the like.
- a pull wire 355 which extends through the lumen 150 to the tip 338 and is attached to suitable steering and positioning controls (not illustrated) at the proximal end of the catheter, for controlling bending of the distal end portion.
- suitable steering and positioning controls not illustrated
- Such a pull wire mechanism is described in U.S. Pat. No. 7,004,938 referenced above, the contents of which are incorporated herein by reference. It may be understood that a similar position control mechanism will be provided in the embodiments of FIGS. 4 to 6 , or the mechanism 180 of FIG. 3 may be provided in any of these embodiments.
- FIG. 7 illustrates the distal end portion 400 of a catheter according to another embodiment. Again, some parts of the catheter illustrated in FIG. 7 are identical to those of FIGS. 4 to 6 and like reference numerals have been used as appropriate.
- a tubular body 318 of flexible dielectric material extends the length of the catheter and has a central through bore or lumen 150 and an end portion 320 of reduced outer diameter over which the sleeve 312 containing embedded RF antenna 250 is mounted.
- sleeve 312 is of conductive polymer material and the ends of the antenna are connected to the distal end connector 170 ( FIG.
- an outer cover layer 345 of non-conductive polymer material extends along the entire length of the catheter, over the tubular body 318 and sleeve 312 , and has a forward end or tip 344 covering the forward end of the sleeve and tubular body.
- a pair of contact rings 346 , 348 are mounted in the outer cover layer 345 in the distal end portion of the catheter, with the forward contact ring 346 located over the sleeve 312 and in electrical contact with the sleeve, and the rear contact ring 348 located slightly rearwardly from sleeve 312 .
- Each ring is of a flexible conductive material such as conductive polymer material. Rings 346 , 348 and outer cover layer 345 are suitably bonded together and laminated over the tubular body 318 and conductive polymer sleeve 312 .
- the forward contact ring 346 is connected to the proximal end connector 170 via the conductive sleeve 312 and the outer conductor 316 which also provides power to the antenna 250 .
- the rear contact ring 348 is connected to a conductive wire 350 which extends through the tubular body 318 to the proximal end connector 170 of the catheter.
- the conductors 316 , 350 therefore provide the output for the ECG monitor in the control unit in this embodiment.
- the embodiment of FIG. 7 also includes a temperature sensor 352 in the lumen 150 adjacent the tip of the catheter.
- the temperature sensor 352 may be a thermistor, thermocouple, or the like and has a thermocouple junction or sensor end 352 and a pair of braided wires or conductors 354 extending from the sensor 352 through the tubular body to the connector 170 at the proximal end of the catheter, where they are connected to control circuitry for monitoring the temperature at the distal end of the catheter and controlling the antenna operation.
- a pull wire 355 is attached to the tip 344 of the catheter and extends through the central lumen 150 through the length of the catheter for attachment to a suitable steering and control mechanism (not illustrated), as in the previous embodiment.
- FIG. 8 illustrates a modification of the embodiment of FIG. 5 , and like reference numerals are used for like parts as appropriate.
- a tubular body 318 of dielectric material having a central lumen 150 extends the entire length of the catheter, and has a reduced outer diameter portion 320 at the distal end portion 500 of the catheter.
- Conductive sleeve 312 is mounted over the portion 320 and the RF antenna 250 is embedded in sleeve 312 .
- the electrodes comprise the conductive sleeve 312 and a conductive tip 330 mounted over the end of the catheter, with a layer 332 of non-conductive material such as non-conductive polymer between the electrodes 312 and 330 .
- the various layers of conductive and non-conductive materials in the embodiment of FIG. 8 will also be laminated together by any suitable means such as heat, adhesives and mechanical force.
- thermocouple wires 510 which extend through lumen 150 from the proximal end connector 170 of the catheter and into the conductive tip electrode 330 , with a thermocouple junction 512 at the end of the double wires providing a temperature sensor.
- the thermocouple wires therefore have the dual function of providing a temperature sensor output as well as providing an ECG monitor output in combination with outer antenna conductor 316 .
- the ECG output may be measured between conductor 316 and either one of the thermocouple wires 510 .
- the temperature output may be used in monitoring and controlling operation of the RF antenna, as described above in connection with FIG. 7 .
- electrodes are mounted at the distal end portion of a shapeable or bendable catheter to allow physicians to locate a tissue region causing problems and to obtain both optimum tissue proximity and electrical conductive activities before and after ablation, as well as to obtain feedback of their actions.
- two electrodes are provided in these embodiments, only one electrode or more than two electrodes may be provided in other embodiments.
- the electrode or electrodes in these embodiments may be ECG or other types of electrodes.
- Radio-opaque markers (not illustrated) at the distal end portion of the catheter may also be used to aid in positioning the tip of the catheter, as is known in the field.
- the conductor wires connected to the electrodes and to the proximal end connector 170 of the catheter will communicate with an external ECG system and monitor (not illustrated) via a suitable connection cable which will transmit ECG signals between the electrodes and ECG system.
- the antenna conductors and thermocouple wires (if a temperature sensor is present) will be similarly connected to an appropriate antenna output control system.
- the RF antenna 250 is adapted to receive and radiate electromagnetic energy in order to treat a selected biological tissue site.
- An example of a suitable spectrum of radio frequency energy for use in the ablation catheter is that of the microwave frequency range above 300 MHz.
- the RF antenna is capable of applying substantially uniformly distributed electromagnetic field energy along the RF antenna in a direction substantially normal to the longitudinal axis of antenna 250 .
- the electrodes in the embodiments of FIGS. 4 to 8 are made of a suitable flexible conductive material, so that they can bend with the remainder of the distal end portion during steering. Such electrodes avoid or reduce the problems encountered with metallic electrodes, since they do not absorb microwave energy to any great extent and do not become excessively hot.
- the electrodes may be of an at least substantially non-metallic material, and in one embodiment they are made from a conductive polymer material such as nylon, polyethylene, polyolefin, polypropylene, polycarbonate, Pebax®, TPE (thermoplastic elastomers) and blends, loaded with a selective conductive material.
- Other non-conductive parts of the catheter may be of the same polymer material or different polymer materials.
- the conductive material may be micro-carbon spheres, carbon particles, carbon nanotubes, nickel dust, or the like.
- the electrodes may be made entirely of conductive polymer material or may be a mixture of conductive and non-conductive polymer material, or a mixture of conductive and non-conductive materials with metal substrates.
- the composite polymer material is selected to have a relatively low resistance for reduced interference with the microwave radiation pattern, and to be hydrophilic for improved wetability on the outer surface of the catheter.
- Communication between the electrodes and the connector 170 at the proximal end of the catheter may be provided in some embodiments by means of conductive ink or adhesive applied over the polymer surface.
- conductor 324 of FIG. 4 or conductor 342 of FIG. 6 may be a line of conductive ink or adhesive over the outer surface of the tubular body 318 extending from electrode ring 314 to the proximal end of the catheter.
- Conductor 350 of FIG. 7 may be a line of conductive ink or adhesive over the outer surface of non-conductive tubular body 318 , with the outer layer 345 of non-conductive polymer laminated over the tubular body and conductor line 350 .
- Heat energy, adhesives, and/or mechanical force may be used to laminate the conductive and non-conductive polymer layers in the embodiments of FIGS. 4 to 8 .
- Metallic substrates may also be laminated between the polymer layers, such as the inner and outer tubular conductors which provide power for operating RF antenna 250 .
Abstract
Description
- The present application is a continuation-in-part of co-pending U.S. patent application Ser. No. 11/359,808 of concurrent ownership, filed on Feb. 22, 2006, which is a divisional of U.S. patent application Ser. No. 10/306,757, filed Nov. 27, 2002, now U.S. Pat. No. 7,004,938, which claims the benefit of Provisional Application No. 60/334,199, filed Nov. 29, 2001 and the contents of each of these documents are incorporated herein by reference in their entirety.
- 1. Field of the Invention
- The present invention generally relates to medical devices used for ablation of biological tissues, and more particularly to an ablation catheter apparatus incorporating one or more electrodes such as electrocardiogram (ECG) electrodes.
- 2. Related Art
- Ablation catheters apply energy to a biological tissue site which requires ablation. Such catheters may use various energy modes, such as radiofrequency, ultrasound, laser, cryogenic, and the like. Radio frequency (“RF”) ablation catheters generally operate in the microwave frequency range and are used to destroy or ablate biological tissues for therapeutic purposes. In one application, microwave ablation catheters are used to ablate cardiac tissues that cause irregular heartbeats or arrhythmia, avoiding the need for more risky and invasive open heart surgery. In a microwave ablation procedure, the catheter-antenna is passed through the vein for access to the atrium. Within the atrium, the antenna is positioned at the desired location where ablation is required. An intracardiac electrogram is used to identify conductive pathways at the cardiac tissue site that needs to be ablated.
- Prior art ablation catheters have been equipped with two or more electrocardiogram (“ECG”) electrode rings or buttons made of electrically conductive material to provide the necessary output signal for identification of the desired ablation site. Traditionally, all catheters used for this purpose are installed with metallic electrodes, regardless of energy mode (RF, ultrasound, laser, cryogenic, or the like). Installing metallic electrodes over a microwave antenna has special challenges. Naked metallic electrodes installed wrongly can absorb ablation energy and become hot. Hot electrodes can have adverse effects on the heart or other biological tissues or organs, such as blood clot formation, adherence to tissue, and tissue charring. Naked metallic electrodes can also impede efficient delivery of energy and hinder ablation efficiency. Additionally, metallic electrodes can separate from the catheter when it is bent, resulting in inaccurate or lost signals.
- Accordingly, what is needed is an efficient system and method for providing an ECG output signal from an ablation catheter device.
- The ablation catheter system of this invention comprises an elongate catheter adapted for insertion into a body vessel of a patient, the catheter having a distal end portion adapted for positioning adjacent a biological tissue site requiring treatment and a proximal end portion having a connector for connection to a control unit for controlling the ablation procedure, an antenna disposed at the distal end portion of the catheter for providing output energy for tissue ablation purposes, a pair of conductors extending through the catheter from the proximal end portion and connected to the antenna for providing power to the antenna from a power supply in the control unit, and at least one electrode formed of a flexible conductive material disposed at the distal end portion of the antenna and connected to the connector at the proximal end portion of the catheter for providing an output signal to the control unit. The flexible conductive material is at least substantially non-metallic.
- One or more electrodes may be disposed at the distal end portion of the catheter. In one embodiment, the electrode or electrodes are of conductive polymer material with hydrophilic characteristics for improved wetability. Two spaced electrode rings are mounted on or embedded in the outer surface of the cathode. Alternatively, one electrode ring may be provided and the other electrode may be a tip of conductive polymer material at the distal end of the catheter. In alternative embodiments, layers of conductive and nonconductive polymer material may be provided at specific positions at the distal end portion of the catheter to produce multiple working electrodes. In each case, the electrode output signal can be connected to a suitable electrode recording system inputs in the control unit or a separate electrocardiogram unit to provide intracardiac signal mapping.
- This arrangement avoids the problems of metallic electrodes and also provides electrodes which are of a flexible polymer material which can bend readily with the distal end portion of the catheter as it is shaped or bent to negotiate a path through a body vessel.
- Other features and advantages of the present invention will become more readily apparent to those of ordinary skill in the art after reviewing the following detailed description and accompanying drawings.
- The details of the present invention, both as to its structure and operation, may be gleaned in part by study of the accompanying drawings, in which like reference numerals refer to like parts, and in which:
-
FIGS. 1A and 1B are side elevation views of a shapeable RF ablation catheter according to one embodiment in a straight and bent configuration, respectively; -
FIGS. 2A and 2B are side elevation views of a shapeable RF ablation catheter according to another embodiment with a different steering mechanism fromFIG. 1 ; -
FIGS. 3A and 3B are cross sectional views of the distal end portion of the tip of the catheter ofFIG. 1 or 2 in a straight configuration and a bent configuration, respectively; -
FIG. 4 is a cross-sectional view of the tip or distal end portion of one embodiment of a shapeable or bendable RF ablation catheter incorporating electrodes; -
FIG. 5 is a cross-sectional view of the tip or distal end portion of a shapeable or bendable RF ablation catheter having a modified electrode arrangement according to another embodiment; -
FIG. 6 is a cross-sectional view of the tip or distal end portion of a shapeable or bendable RF ablation catheter with another electrode arrangement; -
FIG. 7 is a cross-sectional view of the tip or distal end portion of a shapeable or bendable RF ablation catheter with a modified electrode arrangement according to another embodiment; and -
FIG. 8 is a cross-sectional view of the tip or distal end portion of a shapeable or bendable RF ablation catheter with modified electrodes according to another embodiment. - Certain embodiments as disclosed herein provide for systems and methods for ablation of biological tissues in body areas such as the heart, liver, and the like using a bendable radio-frequency (RF) catheter. The catheter is provided with electrodes of a flexible conductive material such as a conductive polymer at its distal end for providing an output signal such as an intracardiac electrocardiogram (“ECG”) signal to a control unit to allow physicians to obtain tissue proximity and electrical conductivity information both before and after tissue ablation, as well as to provide other feedback during the ablation procedure.
- After reading this description, it will become apparent to one skilled in the art how to implement the invention in various alternative embodiments and alternative applications. However, although various embodiments of the present invention will be described herein, it is understood that these embodiments are presented by way of example only and not limitation. As such, this detailed description of various alternative embodiments should not be construed to limit the scope or breadth of the present invention as set forth in the appended claims.
-
FIGS. 1A and 1B illustrate a radio-frequency (“RF”)ablation catheter system 100 of one embodiment including ashapeable catheter device 100 adapted for insertion into a body vessel of a patient and incorporating an RF antenna for delivering electromagnetic energy to a treatment site, as described in more detail below. - The
catheter device 100 has a flexible, elongatedtubular body 120 having aproximal portion 130 and a distal ortip portion 140. Located at the proximal portion of the body is ahandle chassis 160 containing steering and positioning controls (not illustrated) for the body, activated byactuator 200. In the embodiment ofFIGS. 1A and 1B , the tip portion of the catheter body is activated to bend between the straight configuration ofFIG. 1A and the bent configuration ofFIG. 1B by sliding the actuator back and forth in an axial direction. In the modified embodiment ofFIGS. 2A and 2B , the tip portion is bent between the straight and bent configurations by rotating the actuator orcollar 220. Suitable mechanisms for controlling bending of the tip portion ofcatheter body 120 are described in detail in U.S. Pat. No. 7,004,938 of Ormsby et al., the contents of which are incorporated herein by reference. However, it will be understood that any suitable mechanism may be incorporated in the catheter device in order to control the bending or steering of the tip portion as it moves through a body vessel, organ, or cavity. - A coupling or
electrical connector 170 is provided at the proximal end of the catheter device for connecting the catheter to a control unit or the like containing one or more electronic devices such as an RF generator and controller (not shown) for providing power to the antenna during an ablation procedure. Suitable signal control units are known in the ablation catheter field and are therefore not described in detail here. - The dimensions of the catheter body are adapted as required to suit the particular medical procedure, as is well known in the medical art. In one embodiment, the catheter is used to ablate cardiac tissue. However, the catheter may be used to ablate other types of body tissue in different organs, both internal and external to the body. The
tubular body 120 of the catheter device may be generally constructed of a polymer material which is bio-compatible with the body vessel environment. Examples of such materials include thermoplastic elastomer material such as Pebaxg available from Autochem Germany, polyethylene, polyurethane, polyester, polyimide, polyamide, and the like, with varying degrees of radiopacity, hardness, and elasticity. - The tubular body of the catheter may be formed with a plurality of segments using one or more of the aforementioned materials or equivalents, such that the
catheter body 120 is progressively more flexible towards its distal end. The segments may be joined together by thermal bonding, butt joints, or adhesive bonding. Braiding reinforcement may be provided to the surface of the tubular body to attain a desirable level of stiffness and torsional strength for the catheter to advance and negotiate through the body vessel of the patient, while still allowing the distal end portion to be bent when needed. Thedistal end portion 140 may be of a softer polymer compound than the remainder of the body, with little or no braiding or reinforcement, to provide the desired flexibility for distal deflection and shaping of the apparatus. - The structure of the catheter in one embodiment will now be described in more detail with reference to
FIGS. 3A and 3B . As noted above, the catheter has a tubular body with acentral bore 150 and a closed distal end or tip. The tip may be open in alternative embodiments. In the illustrated embodiment, deflection of the distal end portion of the catheter is accomplished by use of apre-shaped deflection member 180 which is constrained in a straight orientation in the configuration ofFIG. 3A and which adopts a bent shape when extended into the bent configuration ofFIG. 3B . However, it will be understood that other bending or shaping mechanisms may be used in alternative embodiments, as described, for example, in U.S. Pat. No. 7,004,938 referenced above. Thedistal end portion 140 of the tubular body includes anRF antenna 250 comprising a flexible, helically coiledradiating antenna device 255 embedded in the flexible wall of the tubular body, as best illustrated inFIGS. 3A and 3B . The antenna device can therefore bend as the distal end portion is shaped to conform to a body vessel or the like, as illustrated inFIG. 3B . Opposite ends of the antenna device are connected to electrical conductors or leads for connection to theproximal end connector 170 and thereby to a source of RF energy in the catheter control unit (not illustrated), as will be described in more detail below in connection withFIG. 4 . Other antenna devices may be provided in alternative embodiments, and the diameter, pitch and length of thecoiled device 255, and the conductive material used for thedevice 255, may vary according to the particular procedure and flexibility requirements. - The electrical conductors which connect the RF antenna to the
connector 170 may be of a flexible mesh orbraided wire construction 260 or of a thin-film electrically conductive material. In the embodiment illustrated inFIGS. 3A and 3B , the conductors are shown schematically as a mesh construction embedded in the walls of thetubular body 120 of the catheter. In alternative arrangements, separate conductors may be used to provide power to theantenna 250.FIG. 4 illustrates thedistal end portion 310 of a first embodiment of a modified catheter having integratedelectrodes FIG. 4 , in other embodiments one electrode or more than two such electrodes may be provided. Some parts of the catheter ofFIG. 4 are identical to those in FIGS. 1 to 3 and like reference numerals have been used for like parts, as appropriate. In the embodiment ofFIG. 4 , a pair of coaxial inner and outertubular conductors tubular body 318, with theouter conductor 316 connected to the proximal end ofRF antenna 250 and theinner conductor 315 connected to the distal end of the RF antenna adjacent the tip of the catheter. The structure of the remainder of thetubular body 318 which is not shown inFIG. 4 may be identical to that oftubular body 120 described above, and a similar connector 170 (not illustrated) may be provided at the proximal end of the catheter for connecting the conductors to a suitable RF source. The distal end portion illustrated inFIG. 4 will be shapeable or bendable in a similar manner and using the same or similar control devices as were described above in connection with FIGS. 1 to 3. - In the embodiment of
FIG. 4 , thetubular body 318 is of dielectric material such as a non-conductive polymer and has aportion 320 of reduced outer diameter at its forward end. Thefirst electrode 312 comprises a sleeve of flexible conductive material mounted over the reduceddiameter end portion 320 of the tubular body and having an end portion ortip 322 extending over the open end ofportion 320. The RF ormicrowave antenna 250 is embedded in the sleeve orelectrode 312. The inner andouter conductors tubular body 318 as illustrated for connection to the opposite ends of theantenna coil 250. Thesecond electrode 314 comprises a ring of flexible conductive material mounted over thetubular body 318 at a location spaced rearwardly from the rear end of conductive sleeve orelectrode 312. The two electrodes may be secured over the innertubular body 318 by adhesive, bonding, mechanical force, heat sealing or the like. The flexible conductive material forming the electrodes is at least substantially non-metallic material and may be a conductive polymer material which is sufficiently bendable to allow bending of thedistal end portion 310 between the positions illustrated inFIGS. 1A and 1B . - In an alternative embodiment, the
electrode ring 314 may be mounted flush in an annular recess or gap in the outer surface of the tubular body, or may be molded integrally with the tubular body, so that it does not project outwardly from the outer surface of thebody 318. A conductor orconnector 324 extends fromelectrode ring 314 to theconnector 170 at the proximal end of the catheter, for suitable connection to an ECG monitor or the like in a control unit (not illustrated) for the catheter.Conductor 324 is shown spaced from the outer surface ofbody 318 inFIG. 4 for clarity, but may be a line of conductive ink or adhesive over the outer surface of the tubular body, or may alternatively be embedded in thebody 318outside conductor 316, One of theconductors electrodes -
FIG. 5 illustrates thedistal end portion 325 of a catheter with a modified electrode arrangement in which theelectrode ring 314 ofFIG. 4 is replaced by anelectrode end cap 330.Electrodes FIG. 4 . In this embodiment, theconductive sleeve 312 in which the antenna is mounted has anouter cover layer 332 of non-conductive polymer material extending along at least part of its length and over its distal end, providing a non-conductive shield layer between the first andsecond electrodes connector wire 334 extends from the connector at the proximal end of the catheter through thecentral lumen 150 of thetubular body 318 and into theelectrode end cap 330 to provide a signal path between the electrode and the ECG monitor. The catheter ofFIG. 5 is otherwise identical to that of the previous embodiment and like reference numerals have been used as appropriate.Conductive sleeve 312,non-conductive layer 332, andend cap 330 may be laminated together over thetubular body 318 by any suitable means such as bonding, heat sealing, adhesive, or the like. -
FIG. 6 illustrates thedistal end portion 340 of a catheter having another modified electrode arrangement. Parts of the cathode of this embodiment are identical to those ofFIGS. 4 and 5 and like reference numerals have been used for like parts as appropriate. Unlike the previous embodiments, thesleeve 335 in which theantenna coil 250 is embedded does not comprise one of the two electrodes. As in the previous embodiment,sleeve 335 is mounted over the reduceddiameter end portion 320 of thetubular body 318, which is of dielectric or non-conductive material, and theantenna coil 250 is connected at its opposite ends to the distal ends of the inner andouter conductors - In the embodiment of
FIG. 6 , anouter layer 336 of non-conductive material, such as a non-conductive polymer material, extends over theconductive sleeve 335 and has anend cap portion 338 extending over the tip of thetubular body 318. The electrodes in this embodiment comprise a pair ofconductive rings non-conductive layer 336. The ring electrodes may be of conductive polymer material. Thefirst ring 339 is positioned adjacent the non-conductiveend cap portion 338 and thesecond ring 341 is positioned adjacent the rear end of theconductive layer 336. A central conductor orconnector wire 342 extends through the hollow central bore or lumen of thetubular body 318, through the non-conductiveend cap portion 338, and bends back to terminate in the firstconductive ring electrode 339. In one embodiment, the part ofconnector wire 342 shown extending throughlumen 150 may be a line of conductive ink or adhesive on the inner surface oftubular body 318. A second conductor orconnector wire 343 extends along the outside of thetubular body 318 and is connected to the secondconductive ring electrode 341. It will be understood that theconnector wire 343 may comprise a line of conductive ink or adhesive ontubular body 318, or may alternatively be embedded in thetubular body 318 at location spaced outside the outertubular conductor 316. The various conductive and non-conductive polymer layers of thedistal end portion 340, including the electrode rings, are suitably laminated together by heat sealing, adhesive bonding, or the like. - Also shown in
FIG. 6 is apull wire 355 which extends through thelumen 150 to thetip 338 and is attached to suitable steering and positioning controls (not illustrated) at the proximal end of the catheter, for controlling bending of the distal end portion. Such a pull wire mechanism is described in U.S. Pat. No. 7,004,938 referenced above, the contents of which are incorporated herein by reference. It may be understood that a similar position control mechanism will be provided in the embodiments of FIGS. 4 to 6, or themechanism 180 ofFIG. 3 may be provided in any of these embodiments. -
FIG. 7 illustrates thedistal end portion 400 of a catheter according to another embodiment. Again, some parts of the catheter illustrated inFIG. 7 are identical to those of FIGS. 4 to 6 and like reference numerals have been used as appropriate. As in the previous embodiment, atubular body 318 of flexible dielectric material extends the length of the catheter and has a central through bore orlumen 150 and anend portion 320 of reduced outer diameter over which thesleeve 312 containing embeddedRF antenna 250 is mounted. As in the previous embodiments,sleeve 312 is of conductive polymer material and the ends of the antenna are connected to the distal end connector 170 (FIG. 1 ) of the catheter by means of inner and outercylindrical conductors tubular body 318, in the manner described above in connection withFIG. 1 . Unlike the previous embodiments, anouter cover layer 345 of non-conductive polymer material extends along the entire length of the catheter, over thetubular body 318 andsleeve 312, and has a forward end or tip 344 covering the forward end of the sleeve and tubular body. A pair of contact rings 346,348 are mounted in theouter cover layer 345 in the distal end portion of the catheter, with theforward contact ring 346 located over thesleeve 312 and in electrical contact with the sleeve, and therear contact ring 348 located slightly rearwardly fromsleeve 312. Each ring is of a flexible conductive material such as conductive polymer material.Rings outer cover layer 345 are suitably bonded together and laminated over thetubular body 318 andconductive polymer sleeve 312. - The
forward contact ring 346 is connected to theproximal end connector 170 via theconductive sleeve 312 and theouter conductor 316 which also provides power to theantenna 250. Therear contact ring 348 is connected to aconductive wire 350 which extends through thetubular body 318 to theproximal end connector 170 of the catheter. Theconductors - The embodiment of
FIG. 7 also includes atemperature sensor 352 in thelumen 150 adjacent the tip of the catheter. In the illustrated embodiment, thetemperature sensor 352 may be a thermistor, thermocouple, or the like and has a thermocouple junction orsensor end 352 and a pair of braided wires orconductors 354 extending from thesensor 352 through the tubular body to theconnector 170 at the proximal end of the catheter, where they are connected to control circuitry for monitoring the temperature at the distal end of the catheter and controlling the antenna operation. Apull wire 355 is attached to thetip 344 of the catheter and extends through thecentral lumen 150 through the length of the catheter for attachment to a suitable steering and control mechanism (not illustrated), as in the previous embodiment. - A system for monitoring and controlling operation of an RF ablation catheter incorporating a temperature sensor is described in co-pending application Ser. No. 11/479,259 filed on Jun. 30, 2006, the contents of which are incorporated herein by reference. It will be understood that a similar control system may be provided for controlling operation of the microwave antenna in this embodiment or other embodiments described above, with suitable inclusion of a temperature sensor.
-
FIG. 8 illustrates a modification of the embodiment ofFIG. 5 , and like reference numerals are used for like parts as appropriate. In this embodiment, as in the previous embodiments, atubular body 318 of dielectric material having acentral lumen 150 extends the entire length of the catheter, and has a reducedouter diameter portion 320 at thedistal end portion 500 of the catheter.Conductive sleeve 312 is mounted over theportion 320 and theRF antenna 250 is embedded insleeve 312. As in the embodiment ofFIG. 5 , the electrodes comprise theconductive sleeve 312 and aconductive tip 330 mounted over the end of the catheter, with alayer 332 of non-conductive material such as non-conductive polymer between theelectrodes FIG. 8 will also be laminated together by any suitable means such as heat, adhesives and mechanical force. - In
FIG. 8 , theconductive wire 334 which is connected to theconductive tip electrode 330 ofFIG. 5 is eliminated, and is replaced withdouble thermocouple wires 510 which extend throughlumen 150 from theproximal end connector 170 of the catheter and into theconductive tip electrode 330, with athermocouple junction 512 at the end of the double wires providing a temperature sensor. The thermocouple wires therefore have the dual function of providing a temperature sensor output as well as providing an ECG monitor output in combination withouter antenna conductor 316. The ECG output may be measured betweenconductor 316 and either one of thethermocouple wires 510. The temperature output may be used in monitoring and controlling operation of the RF antenna, as described above in connection withFIG. 7 . - In each of the embodiments of FIGS. 4 to 8, electrodes are mounted at the distal end portion of a shapeable or bendable catheter to allow physicians to locate a tissue region causing problems and to obtain both optimum tissue proximity and electrical conductive activities before and after ablation, as well as to obtain feedback of their actions. Although two electrodes are provided in these embodiments, only one electrode or more than two electrodes may be provided in other embodiments. The electrode or electrodes in these embodiments may be ECG or other types of electrodes. Radio-opaque markers (not illustrated) at the distal end portion of the catheter may also be used to aid in positioning the tip of the catheter, as is known in the field. Where the electrodes are ECG electrodes, it will be understood that the conductor wires connected to the electrodes and to the
proximal end connector 170 of the catheter will communicate with an external ECG system and monitor (not illustrated) via a suitable connection cable which will transmit ECG signals between the electrodes and ECG system. The antenna conductors and thermocouple wires (if a temperature sensor is present) will be similarly connected to an appropriate antenna output control system. - In each of the above embodiments, the
RF antenna 250 is adapted to receive and radiate electromagnetic energy in order to treat a selected biological tissue site. An example of a suitable spectrum of radio frequency energy for use in the ablation catheter is that of the microwave frequency range above 300 MHz. The RF antenna is capable of applying substantially uniformly distributed electromagnetic field energy along the RF antenna in a direction substantially normal to the longitudinal axis ofantenna 250. - The electrodes in the embodiments of FIGS. 4 to 8 are made of a suitable flexible conductive material, so that they can bend with the remainder of the distal end portion during steering. Such electrodes avoid or reduce the problems encountered with metallic electrodes, since they do not absorb microwave energy to any great extent and do not become excessively hot. The electrodes may be of an at least substantially non-metallic material, and in one embodiment they are made from a conductive polymer material such as nylon, polyethylene, polyolefin, polypropylene, polycarbonate, Pebax®, TPE (thermoplastic elastomers) and blends, loaded with a selective conductive material. Other non-conductive parts of the catheter may be of the same polymer material or different polymer materials. The conductive material may be micro-carbon spheres, carbon particles, carbon nanotubes, nickel dust, or the like. The electrodes may be made entirely of conductive polymer material or may be a mixture of conductive and non-conductive polymer material, or a mixture of conductive and non-conductive materials with metal substrates. The composite polymer material is selected to have a relatively low resistance for reduced interference with the microwave radiation pattern, and to be hydrophilic for improved wetability on the outer surface of the catheter.
- Communication between the electrodes and the
connector 170 at the proximal end of the catheter may be provided in some embodiments by means of conductive ink or adhesive applied over the polymer surface. For example,conductor 324 ofFIG. 4 orconductor 342 ofFIG. 6 may be a line of conductive ink or adhesive over the outer surface of thetubular body 318 extending fromelectrode ring 314 to the proximal end of the catheter.Conductor 350 ofFIG. 7 may be a line of conductive ink or adhesive over the outer surface of non-conductivetubular body 318, with theouter layer 345 of non-conductive polymer laminated over the tubular body andconductor line 350. - Heat energy, adhesives, and/or mechanical force may be used to laminate the conductive and non-conductive polymer layers in the embodiments of FIGS. 4 to 8. Metallic substrates may also be laminated between the polymer layers, such as the inner and outer tubular conductors which provide power for operating
RF antenna 250. - The above description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles described herein can be applied to other embodiments without departing from the spirit or scope of the invention. Thus, it is to be understood that the description and drawings presented herein represent a presently preferred embodiment of the invention and are, therefore, representative of the subject matter which is broadly contemplated by the present invention. It is further understood that the scope of the present invention fully encompasses other embodiments that may become obvious to those skilled in the art and that the scope of the present invention is accordingly limited by nothing other than the appended claims.
Claims (34)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
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US11/551,162 US20070066972A1 (en) | 2001-11-29 | 2006-10-19 | Ablation catheter apparatus with one or more electrodes |
US11/781,467 US8308722B2 (en) | 1998-12-14 | 2007-07-23 | Hollow conductive coaxial cable for radio frequency based tissue ablation system |
CN2007800389107A CN101534737B (en) | 2006-10-19 | 2007-10-09 | Ablation catheter apparatus with one or more electrodes |
PCT/US2007/080819 WO2008051708A2 (en) | 2006-10-19 | 2007-10-09 | Ablation catheter apparatus with one or more electrodes |
EP07853876.6A EP2073738B1 (en) | 2006-10-19 | 2007-10-09 | Ablation catheter apparatus with one or more electrodes |
ES07853876.6T ES2546754T3 (en) | 2006-10-19 | 2007-10-09 | Ablation catheter apparatus with one or more electrodes |
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US33419901P | 2001-11-29 | 2001-11-29 | |
US10/306,757 US7004938B2 (en) | 2001-11-29 | 2002-11-27 | Radio-frequency-based catheter system with improved deflection and steering mechanisms |
US11/359,808 US7815637B2 (en) | 2001-11-29 | 2006-02-22 | Radio-frequency-based catheter system with improved deflection and steering mechanisms |
US11/551,162 US20070066972A1 (en) | 2001-11-29 | 2006-10-19 | Ablation catheter apparatus with one or more electrodes |
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US11/359,808 Continuation-In-Part US7815637B2 (en) | 1998-12-14 | 2006-02-22 | Radio-frequency-based catheter system with improved deflection and steering mechanisms |
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US11/781,467 Continuation US8308722B2 (en) | 1998-12-14 | 2007-07-23 | Hollow conductive coaxial cable for radio frequency based tissue ablation system |
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US11/781,467 Expired - Fee Related US8308722B2 (en) | 1998-12-14 | 2007-07-23 | Hollow conductive coaxial cable for radio frequency based tissue ablation system |
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Cited By (178)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060041277A1 (en) * | 2002-04-08 | 2006-02-23 | Mark Deem | Methods and apparatus for renal neuromodulation |
US20060142752A1 (en) * | 2001-11-29 | 2006-06-29 | Ormsby Theodore C | Radio-frequency-based catheter system with improved deflection and steering mechanisms |
US20060265015A1 (en) * | 2002-04-08 | 2006-11-23 | Ardian, Inc. | Methods and apparatus for monopolar renal neuromodulation |
US20060265014A1 (en) * | 2002-04-08 | 2006-11-23 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
US20060276852A1 (en) * | 2002-04-08 | 2006-12-07 | Ardian, Inc. | Methods and apparatus for treating hypertension |
US20070129760A1 (en) * | 2002-04-08 | 2007-06-07 | Ardian, Inc. | Methods and apparatus for intravasculary-induced neuromodulation or denervation |
US20080015570A1 (en) * | 1998-12-14 | 2008-01-17 | Ormsby Theodore C | Hollow conductive coaxial cable for radio frequency based tissue ablation system |
EP2008603A1 (en) * | 2007-06-29 | 2008-12-31 | Biosense Webster, Inc. | Ablation catheter with optically transparent electricity conductive tip |
US20090005771A1 (en) * | 2007-06-28 | 2009-01-01 | Chad Allen Lieber | Optical Pyrometric Catheter for Tissue Temperature Monitoring During Cardiac Ablation |
US20090082762A1 (en) * | 2007-09-20 | 2009-03-26 | Ormsby Theodore C | Radio frequency energy transmission device for the ablation of biological tissues |
US20090163916A1 (en) * | 2007-12-21 | 2009-06-25 | Saurav Paul | Flexible Conductive Polymer Electrode and Method for Ablation |
US20090163905A1 (en) * | 2007-12-21 | 2009-06-25 | Winkler Matthew J | Ablation device with internally cooled electrodes |
US20090171187A1 (en) * | 2007-12-26 | 2009-07-02 | Gerhart John P | Catheter electrode that can simultaneously emit electrical energy and facilitate visualization by magnetic resonance imaging |
US20090171188A1 (en) * | 2007-12-28 | 2009-07-02 | Saurav Paul | Flexible polymer electrode for mri-guided positioning and radio frequency ablation |
US20090299360A1 (en) * | 2008-05-28 | 2009-12-03 | Medwaves, Inc. | Tissue ablation apparatus and method using ultrasonic imaging |
US20100004650A1 (en) * | 2008-07-01 | 2010-01-07 | Medwaves, Inc. | Angioplasty and tissue ablation apparatus and method |
US20100121319A1 (en) * | 2008-11-10 | 2010-05-13 | Microcube, Llc | Methods and devices for applying energy to bodily tissues |
US20100125269A1 (en) * | 2008-10-21 | 2010-05-20 | Microcube, Limited Liability Corporation | Microwave treatment devices and methods |
US20100137857A1 (en) * | 2008-10-21 | 2010-06-03 | Microcube, Limited Liability Corporation | Methods and devices for applying energy to bodily tissues |
US20100168739A1 (en) * | 2008-12-31 | 2010-07-01 | Ardian, Inc. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
US20100168731A1 (en) * | 2008-12-31 | 2010-07-01 | Ardian, Inc. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
US20100268219A1 (en) * | 2009-04-15 | 2010-10-21 | Medwaves, Inc. | Radio frequency based ablation system and method with dielectric transformer |
US20110004205A1 (en) * | 2008-10-21 | 2011-01-06 | Chu Chun Yiu | Methods and devices for delivering microwave energy |
US20110130750A1 (en) * | 2009-11-30 | 2011-06-02 | Medwaves, Inc. | Radio frequency ablation system with tracking sensor |
US20110208096A1 (en) * | 2002-04-08 | 2011-08-25 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
US8131372B2 (en) | 2002-04-08 | 2012-03-06 | Ardian, Inc. | Renal nerve stimulation method for treatment of patients |
US8150520B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods for catheter-based renal denervation |
US8433423B2 (en) | 2004-10-05 | 2013-04-30 | Ardian, Inc. | Methods for multi-vessel renal neuromodulation |
US8454594B2 (en) | 2002-04-08 | 2013-06-04 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatus for performing a non-continuous circumferential treatment of a body lumen |
US20130204279A1 (en) * | 2010-05-07 | 2013-08-08 | Carefusion 2200, Inc. | Catheter design for use in treating pleural diseases |
WO2013119620A1 (en) * | 2012-02-07 | 2013-08-15 | Advanced Cardiac Therapeutics, Inc. | Systems and methods for radiometrically measuring temperature during tissue ablation |
US8548600B2 (en) | 2002-04-08 | 2013-10-01 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatuses for renal neuromodulation and associated systems and methods |
US8620423B2 (en) | 2002-04-08 | 2013-12-31 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for thermal modulation of nerves contributing to renal function |
US20140012077A1 (en) * | 2011-01-11 | 2014-01-09 | Quanta System S.P.A. | Laser surgery device |
US8684998B2 (en) | 2002-04-08 | 2014-04-01 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for inhibiting renal nerve activity |
US8728075B2 (en) | 2010-04-26 | 2014-05-20 | Medtronic Ardian Luxembourg S.A.R.L. | Multi-directional deflectable catheter apparatuses, systems, and methods for renal neuromodulation |
US8774922B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods |
US8771252B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and devices for renal nerve blocking |
US8818514B2 (en) | 2002-04-08 | 2014-08-26 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for intravascularly-induced neuromodulation |
US8880185B2 (en) | 2010-06-11 | 2014-11-04 | Boston Scientific Scimed, Inc. | Renal denervation and stimulation employing wireless vascular energy transfer arrangement |
US8939970B2 (en) | 2004-09-10 | 2015-01-27 | Vessix Vascular, Inc. | Tuned RF energy and electrical tissue characterization for selective treatment of target tissues |
US8951251B2 (en) | 2011-11-08 | 2015-02-10 | Boston Scientific Scimed, Inc. | Ostial renal nerve ablation |
US8954161B2 (en) | 2012-06-01 | 2015-02-10 | Advanced Cardiac Therapeutics, Inc. | Systems and methods for radiometrically measuring temperature and detecting tissue contact prior to and during tissue ablation |
US8958871B2 (en) | 2002-04-08 | 2015-02-17 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach |
US8961506B2 (en) | 2012-03-12 | 2015-02-24 | Advanced Cardiac Therapeutics, Inc. | Methods of automatically regulating operation of ablation members based on determined temperatures |
US8974451B2 (en) | 2010-10-25 | 2015-03-10 | Boston Scientific Scimed, Inc. | Renal nerve ablation using conductive fluid jet and RF energy |
US8974445B2 (en) | 2009-01-09 | 2015-03-10 | Recor Medical, Inc. | Methods and apparatus for treatment of cardiac valve insufficiency |
WO2015042173A1 (en) * | 2013-09-20 | 2015-03-26 | Advanced Cardiac Therapeutics, Inc. | Temperature sensing and tissue ablation using a plurality of electrodes |
US9023034B2 (en) | 2010-11-22 | 2015-05-05 | Boston Scientific Scimed, Inc. | Renal ablation electrode with force-activatable conduction apparatus |
US9028485B2 (en) | 2010-11-15 | 2015-05-12 | Boston Scientific Scimed, Inc. | Self-expanding cooling electrode for renal nerve ablation |
US9028472B2 (en) | 2011-12-23 | 2015-05-12 | Vessix Vascular, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
US9050106B2 (en) | 2011-12-29 | 2015-06-09 | Boston Scientific Scimed, Inc. | Off-wall electrode device and methods for nerve modulation |
US9060761B2 (en) | 2010-11-18 | 2015-06-23 | Boston Scientific Scime, Inc. | Catheter-focused magnetic field induced renal nerve ablation |
US9079000B2 (en) | 2011-10-18 | 2015-07-14 | Boston Scientific Scimed, Inc. | Integrated crossing balloon catheter |
US9084609B2 (en) | 2010-07-30 | 2015-07-21 | Boston Scientific Scime, Inc. | Spiral balloon catheter for renal nerve ablation |
US9089350B2 (en) | 2010-11-16 | 2015-07-28 | Boston Scientific Scimed, Inc. | Renal denervation catheter with RF electrode and integral contrast dye injection arrangement |
US9119632B2 (en) | 2011-11-21 | 2015-09-01 | Boston Scientific Scimed, Inc. | Deflectable renal nerve ablation catheter |
US9119600B2 (en) | 2011-11-15 | 2015-09-01 | Boston Scientific Scimed, Inc. | Device and methods for renal nerve modulation monitoring |
US9125666B2 (en) | 2003-09-12 | 2015-09-08 | Vessix Vascular, Inc. | Selectable eccentric remodeling and/or ablation of atherosclerotic material |
US9125667B2 (en) | 2004-09-10 | 2015-09-08 | Vessix Vascular, Inc. | System for inducing desirable temperature effects on body tissue |
US9155589B2 (en) | 2010-07-30 | 2015-10-13 | Boston Scientific Scimed, Inc. | Sequential activation RF electrode set for renal nerve ablation |
US9162046B2 (en) | 2011-10-18 | 2015-10-20 | Boston Scientific Scimed, Inc. | Deflectable medical devices |
US9173696B2 (en) | 2012-09-17 | 2015-11-03 | Boston Scientific Scimed, Inc. | Self-positioning electrode system and method for renal nerve modulation |
US9186210B2 (en) | 2011-10-10 | 2015-11-17 | Boston Scientific Scimed, Inc. | Medical devices including ablation electrodes |
US9186209B2 (en) | 2011-07-22 | 2015-11-17 | Boston Scientific Scimed, Inc. | Nerve modulation system having helical guide |
US9192715B2 (en) | 2002-04-08 | 2015-11-24 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for renal nerve blocking |
US9192435B2 (en) | 2010-11-22 | 2015-11-24 | Boston Scientific Scimed, Inc. | Renal denervation catheter with cooled RF electrode |
US9192790B2 (en) | 2010-04-14 | 2015-11-24 | Boston Scientific Scimed, Inc. | Focused ultrasonic renal denervation |
US9220561B2 (en) | 2011-01-19 | 2015-12-29 | Boston Scientific Scimed, Inc. | Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury |
US9220558B2 (en) | 2010-10-27 | 2015-12-29 | Boston Scientific Scimed, Inc. | RF renal denervation catheter with multiple independent electrodes |
US9265969B2 (en) | 2011-12-21 | 2016-02-23 | Cardiac Pacemakers, Inc. | Methods for modulating cell function |
US9277955B2 (en) | 2010-04-09 | 2016-03-08 | Vessix Vascular, Inc. | Power generating and control apparatus for the treatment of tissue |
US9277961B2 (en) | 2009-06-12 | 2016-03-08 | Advanced Cardiac Therapeutics, Inc. | Systems and methods of radiometrically determining a hot-spot temperature of tissue being treated |
US9297845B2 (en) | 2013-03-15 | 2016-03-29 | Boston Scientific Scimed, Inc. | Medical devices and methods for treatment of hypertension that utilize impedance compensation |
US9308044B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US9308043B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
US9327100B2 (en) | 2008-11-14 | 2016-05-03 | Vessix Vascular, Inc. | Selective drug delivery in a lumen |
US9327122B2 (en) | 2002-04-08 | 2016-05-03 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
US9326751B2 (en) | 2010-11-17 | 2016-05-03 | Boston Scientific Scimed, Inc. | Catheter guidance of external energy for renal denervation |
US9358365B2 (en) | 2010-07-30 | 2016-06-07 | Boston Scientific Scimed, Inc. | Precision electrode movement control for renal nerve ablation |
US9364284B2 (en) | 2011-10-12 | 2016-06-14 | Boston Scientific Scimed, Inc. | Method of making an off-wall spacer cage |
US9408661B2 (en) | 2010-07-30 | 2016-08-09 | Patrick A. Haverkost | RF electrodes on multiple flexible wires for renal nerve ablation |
US9420955B2 (en) | 2011-10-11 | 2016-08-23 | Boston Scientific Scimed, Inc. | Intravascular temperature monitoring system and method |
US9433760B2 (en) | 2011-12-28 | 2016-09-06 | Boston Scientific Scimed, Inc. | Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements |
US9439726B2 (en) | 2002-04-08 | 2016-09-13 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US9463062B2 (en) | 2010-07-30 | 2016-10-11 | Boston Scientific Scimed, Inc. | Cooled conductive balloon RF catheter for renal nerve ablation |
US20160310211A1 (en) * | 2014-01-06 | 2016-10-27 | Iowa Approach Inc. | Apparatus and methods for renal denervation ablation |
US9486355B2 (en) | 2005-05-03 | 2016-11-08 | Vessix Vascular, Inc. | Selective accumulation of energy with or without knowledge of tissue topography |
US9510905B2 (en) | 2014-11-19 | 2016-12-06 | Advanced Cardiac Therapeutics, Inc. | Systems and methods for high-resolution mapping of tissue |
US9517103B2 (en) | 2014-11-19 | 2016-12-13 | Advanced Cardiac Therapeutics, Inc. | Medical instruments with multiple temperature sensors |
US9566115B2 (en) | 2009-07-28 | 2017-02-14 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US9579030B2 (en) | 2011-07-20 | 2017-02-28 | Boston Scientific Scimed, Inc. | Percutaneous devices and methods to visualize, target and ablate nerves |
US9636164B2 (en) | 2015-03-25 | 2017-05-02 | Advanced Cardiac Therapeutics, Inc. | Contact sensing systems and methods |
US9649156B2 (en) | 2010-12-15 | 2017-05-16 | Boston Scientific Scimed, Inc. | Bipolar off-wall electrode device for renal nerve ablation |
US9668811B2 (en) | 2010-11-16 | 2017-06-06 | Boston Scientific Scimed, Inc. | Minimally invasive access for renal nerve ablation |
US9687166B2 (en) | 2013-10-14 | 2017-06-27 | Boston Scientific Scimed, Inc. | High resolution cardiac mapping electrode array catheter |
US9693821B2 (en) | 2013-03-11 | 2017-07-04 | Boston Scientific Scimed, Inc. | Medical devices for modulating nerves |
US9700372B2 (en) | 2002-07-01 | 2017-07-11 | Recor Medical, Inc. | Intraluminal methods of ablating nerve tissue |
US9707036B2 (en) | 2013-06-25 | 2017-07-18 | Boston Scientific Scimed, Inc. | Devices and methods for nerve modulation using localized indifferent electrodes |
US9713730B2 (en) | 2004-09-10 | 2017-07-25 | Boston Scientific Scimed, Inc. | Apparatus and method for treatment of in-stent restenosis |
US9770606B2 (en) | 2013-10-15 | 2017-09-26 | Boston Scientific Scimed, Inc. | Ultrasound ablation catheter with cooling infusion and centering basket |
US9808300B2 (en) | 2006-05-02 | 2017-11-07 | Boston Scientific Scimed, Inc. | Control of arterial smooth muscle tone |
US9808311B2 (en) | 2013-03-13 | 2017-11-07 | Boston Scientific Scimed, Inc. | Deflectable medical devices |
US9827039B2 (en) | 2013-03-15 | 2017-11-28 | Boston Scientific Scimed, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
US9833283B2 (en) | 2013-07-01 | 2017-12-05 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation |
US9861440B2 (en) | 2010-05-03 | 2018-01-09 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US20180008346A1 (en) * | 2016-07-11 | 2018-01-11 | Gyrus Medical Limited | System and method for monitoring tissue temperature |
US20180008345A1 (en) * | 2016-07-11 | 2018-01-11 | Gyrus Medical Limited | System and method for monitoring a microwave tissue ablation process |
US9895194B2 (en) | 2013-09-04 | 2018-02-20 | Boston Scientific Scimed, Inc. | Radio frequency (RF) balloon catheter having flushing and cooling capability |
US9907609B2 (en) | 2014-02-04 | 2018-03-06 | Boston Scientific Scimed, Inc. | Alternative placement of thermal sensors on bipolar electrode |
US9925001B2 (en) | 2013-07-19 | 2018-03-27 | Boston Scientific Scimed, Inc. | Spiral bipolar electrode renal denervation balloon |
US9943365B2 (en) | 2013-06-21 | 2018-04-17 | Boston Scientific Scimed, Inc. | Renal denervation balloon catheter with ride along electrode support |
US9956033B2 (en) | 2013-03-11 | 2018-05-01 | Boston Scientific Scimed, Inc. | Medical devices for modulating nerves |
US9962223B2 (en) | 2013-10-15 | 2018-05-08 | Boston Scientific Scimed, Inc. | Medical device balloon |
US9974607B2 (en) | 2006-10-18 | 2018-05-22 | Vessix Vascular, Inc. | Inducing desirable temperature effects on body tissue |
US9980766B1 (en) | 2014-03-28 | 2018-05-29 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and systems for renal neuromodulation |
US9987081B1 (en) | 2017-04-27 | 2018-06-05 | Iowa Approach, Inc. | Systems, devices, and methods for signal generation |
US9993178B2 (en) | 2016-03-15 | 2018-06-12 | Epix Therapeutics, Inc. | Methods of determining catheter orientation |
US9999465B2 (en) | 2014-10-14 | 2018-06-19 | Iowa Approach, Inc. | Method and apparatus for rapid and safe pulmonary vein cardiac ablation |
US10022182B2 (en) | 2013-06-21 | 2018-07-17 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation having rotatable shafts |
US10080864B2 (en) | 2012-10-19 | 2018-09-25 | Medtronic Ardian Luxembourg S.A.R.L. | Packaging for catheter treatment devices and associated devices, systems, and methods |
US10085799B2 (en) | 2011-10-11 | 2018-10-02 | Boston Scientific Scimed, Inc. | Off-wall electrode device and methods for nerve modulation |
US10130423B1 (en) | 2017-07-06 | 2018-11-20 | Farapulse, Inc. | Systems, devices, and methods for focal ablation |
US10166062B2 (en) | 2014-11-19 | 2019-01-01 | Epix Therapeutics, Inc. | High-resolution mapping of tissue with pacing |
US10172673B2 (en) | 2016-01-05 | 2019-01-08 | Farapulse, Inc. | Systems devices, and methods for delivery of pulsed electric field ablative energy to endocardial tissue |
US10179020B2 (en) | 2010-10-25 | 2019-01-15 | Medtronic Ardian Luxembourg S.A.R.L. | Devices, systems and methods for evaluation and feedback of neuromodulation treatment |
US10194980B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
US10194979B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
WO2018187244A3 (en) * | 2017-04-03 | 2019-03-07 | Broncus Medical Inc. | Electrosurgical access sheath |
US10265122B2 (en) | 2013-03-15 | 2019-04-23 | Boston Scientific Scimed, Inc. | Nerve ablation devices and related methods of use |
US10271898B2 (en) | 2013-10-25 | 2019-04-30 | Boston Scientific Scimed, Inc. | Embedded thermocouple in denervation flex circuit |
US10321946B2 (en) | 2012-08-24 | 2019-06-18 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices with weeping RF ablation balloons |
US10322286B2 (en) | 2016-01-05 | 2019-06-18 | Farapulse, Inc. | Systems, apparatuses and methods for delivery of ablative energy to tissue |
US10342609B2 (en) | 2013-07-22 | 2019-07-09 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation |
US10363092B2 (en) | 2006-03-24 | 2019-07-30 | Neuwave Medical, Inc. | Transmission line with heat transfer ability |
US10376314B2 (en) | 2006-07-14 | 2019-08-13 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US10398464B2 (en) | 2012-09-21 | 2019-09-03 | Boston Scientific Scimed, Inc. | System for nerve modulation and innocuous thermal gradient nerve block |
US10413357B2 (en) | 2013-07-11 | 2019-09-17 | Boston Scientific Scimed, Inc. | Medical device with stretchable electrode assemblies |
US10433906B2 (en) | 2014-06-12 | 2019-10-08 | Farapulse, Inc. | Method and apparatus for rapid and selective transurethral tissue ablation |
US10507302B2 (en) | 2016-06-16 | 2019-12-17 | Farapulse, Inc. | Systems, apparatuses, and methods for guide wire delivery |
US10512505B2 (en) | 2018-05-07 | 2019-12-24 | Farapulse, Inc. | Systems, apparatuses and methods for delivery of ablative energy to tissue |
US10531917B2 (en) | 2016-04-15 | 2020-01-14 | Neuwave Medical, Inc. | Systems and methods for energy delivery |
US10549127B2 (en) | 2012-09-21 | 2020-02-04 | Boston Scientific Scimed, Inc. | Self-cooling ultrasound ablation catheter |
US10617867B2 (en) | 2017-04-28 | 2020-04-14 | Farapulse, Inc. | Systems, devices, and methods for delivery of pulsed electric field ablative energy to esophageal tissue |
US10624693B2 (en) | 2014-06-12 | 2020-04-21 | Farapulse, Inc. | Method and apparatus for rapid and selective tissue ablation with cooling |
US10625080B1 (en) | 2019-09-17 | 2020-04-21 | Farapulse, Inc. | Systems, apparatuses, and methods for detecting ectopic electrocardiogram signals during pulsed electric field ablation |
US10660703B2 (en) | 2012-05-08 | 2020-05-26 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices |
US10660698B2 (en) | 2013-07-11 | 2020-05-26 | Boston Scientific Scimed, Inc. | Devices and methods for nerve modulation |
US10660702B2 (en) | 2016-01-05 | 2020-05-26 | Farapulse, Inc. | Systems, devices, and methods for focal ablation |
US10667860B2 (en) | 2011-12-21 | 2020-06-02 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US10687892B2 (en) | 2018-09-20 | 2020-06-23 | Farapulse, Inc. | Systems, apparatuses, and methods for delivery of pulsed electric field ablative energy to endocardial tissue |
US10695124B2 (en) | 2013-07-22 | 2020-06-30 | Boston Scientific Scimed, Inc. | Renal nerve ablation catheter having twist balloon |
US10722300B2 (en) | 2013-08-22 | 2020-07-28 | Boston Scientific Scimed, Inc. | Flexible circuit having improved adhesion to a renal nerve modulation balloon |
US10835305B2 (en) | 2012-10-10 | 2020-11-17 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices and methods |
US10842572B1 (en) | 2019-11-25 | 2020-11-24 | Farapulse, Inc. | Methods, systems, and apparatuses for tracking ablation devices and generating lesion lines |
US10874455B2 (en) | 2012-03-08 | 2020-12-29 | Medtronic Ardian Luxembourg S.A.R.L. | Ovarian neuromodulation and associated systems and methods |
US10888373B2 (en) | 2017-04-27 | 2021-01-12 | Epix Therapeutics, Inc. | Contact assessment between an ablation catheter and tissue |
US10893905B2 (en) | 2017-09-12 | 2021-01-19 | Farapulse, Inc. | Systems, apparatuses, and methods for ventricular focal ablation |
US10905494B2 (en) | 2011-12-29 | 2021-02-02 | St. Jude Medical, Atrial Fibrillation Division, Inc | Flexible conductive polymer based conformable device and method to create linear endocardial lesions |
US10945786B2 (en) | 2013-10-18 | 2021-03-16 | Boston Scientific Scimed, Inc. | Balloon catheters with flexible conducting wires and related methods of use and manufacture |
US10952792B2 (en) | 2015-10-26 | 2021-03-23 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US10952790B2 (en) | 2013-09-13 | 2021-03-23 | Boston Scientific Scimed, Inc. | Ablation balloon with vapor deposited cover layer |
US11000679B2 (en) | 2014-02-04 | 2021-05-11 | Boston Scientific Scimed, Inc. | Balloon protection and rewrapping devices and related methods of use |
US11020180B2 (en) | 2018-05-07 | 2021-06-01 | Farapulse, Inc. | Epicardial ablation catheter |
US11033236B2 (en) | 2018-05-07 | 2021-06-15 | Farapulse, Inc. | Systems, apparatuses, and methods for filtering high voltage noise induced by pulsed electric field ablation |
US20210196378A1 (en) * | 2018-08-13 | 2021-07-01 | The University Of Sydney | Catheter ablation device with temperature monitoring |
US11065047B2 (en) | 2019-11-20 | 2021-07-20 | Farapulse, Inc. | Systems, apparatuses, and methods for protecting electronic components from high power noise induced by high voltage pulses |
US11202671B2 (en) | 2014-01-06 | 2021-12-21 | Boston Scientific Scimed, Inc. | Tear resistant flex circuit assembly |
US11219484B2 (en) | 2008-10-21 | 2022-01-11 | Microcube, Llc | Methods and devices for delivering microwave energy |
US11246654B2 (en) | 2013-10-14 | 2022-02-15 | Boston Scientific Scimed, Inc. | Flexible renal nerve ablation devices and related methods of use and manufacture |
US11259869B2 (en) | 2014-05-07 | 2022-03-01 | Farapulse, Inc. | Methods and apparatus for selective tissue ablation |
US11291503B2 (en) * | 2008-10-21 | 2022-04-05 | Microcube, Llc | Microwave treatment devices and methods |
US11338140B2 (en) | 2012-03-08 | 2022-05-24 | Medtronic Ardian Luxembourg S.A.R.L. | Monitoring of neuromodulation using biomarkers |
US11389235B2 (en) | 2006-07-14 | 2022-07-19 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US11426573B2 (en) | 2012-08-09 | 2022-08-30 | University Of Iowa Research Foundation | Catheters, catheter systems, and methods for puncturing through a tissue structure and ablating a tissue region |
US11497541B2 (en) | 2019-11-20 | 2022-11-15 | Boston Scientific Scimed, Inc. | Systems, apparatuses, and methods for protecting electronic components from high power noise induced by high voltage pulses |
US11672596B2 (en) | 2018-02-26 | 2023-06-13 | Neuwave Medical, Inc. | Energy delivery devices with flexible and adjustable tips |
US11832879B2 (en) | 2019-03-08 | 2023-12-05 | Neuwave Medical, Inc. | Systems and methods for energy delivery |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7137980B2 (en) | 1998-10-23 | 2006-11-21 | Sherwood Services Ag | Method and system for controlling output of RF medical generator |
US6702811B2 (en) | 1999-04-05 | 2004-03-09 | Medtronic, Inc. | Ablation catheter assembly with radially decreasing helix and method of use |
US7087061B2 (en) * | 2002-03-12 | 2006-08-08 | Lithotech Medical Ltd | Method for intracorporeal lithotripsy fragmentation and apparatus for its implementation |
EP1617776B1 (en) | 2003-05-01 | 2015-09-02 | Covidien AG | System for programing and controlling an electrosurgical generator system |
US8104956B2 (en) | 2003-10-23 | 2012-01-31 | Covidien Ag | Thermocouple measurement circuit |
US7396336B2 (en) | 2003-10-30 | 2008-07-08 | Sherwood Services Ag | Switched resonant ultrasonic power amplifier system |
US7771411B2 (en) | 2004-09-24 | 2010-08-10 | Syntheon, Llc | Methods for operating a selective stiffening catheter |
US7947039B2 (en) * | 2005-12-12 | 2011-05-24 | Covidien Ag | Laparoscopic apparatus for performing electrosurgical procedures |
CA2574934C (en) * | 2006-01-24 | 2015-12-29 | Sherwood Services Ag | System and method for closed loop monitoring of monopolar electrosurgical apparatus |
US9814372B2 (en) | 2007-06-27 | 2017-11-14 | Syntheon, Llc | Torque-transmitting, variably-flexible, locking insertion device and method for operating the insertion device |
US10123683B2 (en) | 2006-03-02 | 2018-11-13 | Syntheon, Llc | Variably flexible insertion device and method for variably flexing an insertion device |
JP4621621B2 (en) * | 2006-03-31 | 2011-01-26 | 株式会社東芝 | Charged beam lithography system |
JP2008235464A (en) * | 2007-03-19 | 2008-10-02 | Toshiba Corp | Electron-beam drafting apparatus |
US8262652B2 (en) | 2009-01-12 | 2012-09-11 | Tyco Healthcare Group Lp | Imaginary impedance process monitoring and intelligent shut-off |
US9326819B2 (en) * | 2009-04-15 | 2016-05-03 | Medwaves, Inc. | Electrically tunable tissue ablation system and method |
US9375273B2 (en) * | 2009-09-18 | 2016-06-28 | Covidien Lp | System and method for checking high power microwave ablation system status on startup |
US9743980B2 (en) * | 2010-02-24 | 2017-08-29 | Safepass Vascular Ltd | Method and system for assisting a wire guide to cross occluded ducts |
US8777963B2 (en) * | 2010-02-24 | 2014-07-15 | Lithotech Medical Ltd | Method and system for destroying of undesirable formations in mammalian body |
US20110213355A1 (en) * | 2010-03-01 | 2011-09-01 | Vivant Medical, Inc. | Sensors On Patient Side for a Microwave Generator |
BR112013010007A2 (en) | 2010-10-25 | 2017-10-24 | Medtronic Ardian Luxembourg | catheter apparatus |
TW201221174A (en) | 2010-10-25 | 2012-06-01 | Medtronic Ardian Luxembourg | Microwave catheter apparatuses, systems, and methods for renal neuromodulation |
US20120123326A1 (en) * | 2010-11-12 | 2012-05-17 | Christian Steven C | Catheter systems with distal end function, such as distal deflection, using remote actuation or low input force |
EP2678067A4 (en) * | 2011-02-24 | 2015-02-25 | Mri Interventions Inc | Mri-guided catheters |
US9028482B2 (en) | 2011-07-19 | 2015-05-12 | Covidien Lp | Microwave and RF ablation system and related method for dynamic impedance matching |
US8968297B2 (en) | 2011-07-19 | 2015-03-03 | Covidien Lp | Microwave and RF ablation system and related method for dynamic impedance matching |
US9192422B2 (en) | 2011-07-19 | 2015-11-24 | Covidien Lp | System and method of matching impedances of an electrosurgical generator and/or a microwave generator |
US9820811B2 (en) | 2011-08-26 | 2017-11-21 | Symap Medical (Suzhou), Ltd | System and method for mapping the functional nerves innervating the wall of arteries, 3-D mapping and catheters for same |
US8702619B2 (en) | 2011-08-26 | 2014-04-22 | Symap Holding Limited | Mapping sympathetic nerve distribution for renal ablation and catheters for same |
EP2747691B1 (en) | 2011-08-26 | 2019-10-09 | Symap Medical (Suzhou) Ltd | System for locating and identifying functional nerves innervating wall of arteries |
US8692992B2 (en) | 2011-09-22 | 2014-04-08 | Covidien Lp | Faraday shield integrated into sensor bandage |
US8726496B2 (en) | 2011-09-22 | 2014-05-20 | Covidien Lp | Technique for remanufacturing a medical sensor |
US8968290B2 (en) | 2012-03-14 | 2015-03-03 | Covidien Lp | Microwave ablation generator control system |
US9190720B2 (en) * | 2012-03-23 | 2015-11-17 | Apple Inc. | Flexible printed circuit structures |
EP2846724B1 (en) | 2012-05-11 | 2016-11-09 | Medtronic Ardian Luxembourg S.à.r.l. | Multi-electrode catheter assemblies for renal neuromodulation and associated systems |
CN103284693B (en) * | 2012-08-24 | 2014-12-24 | 苏州信迈医疗器械有限公司 | Instrument for locating and identifying nerves in vessel wall, and application method thereof |
WO2014064552A1 (en) * | 2012-10-26 | 2014-05-01 | Koninklijke Philips N.V. | System, catheter and planning method for hyperthermia-adjuvant brachytherapy |
US9204921B2 (en) | 2012-12-13 | 2015-12-08 | Cook Medical Technologies Llc | RF energy controller and method for electrosurgical medical devices |
US9364277B2 (en) | 2012-12-13 | 2016-06-14 | Cook Medical Technologies Llc | RF energy controller and method for electrosurgical medical devices |
EP2954865B1 (en) * | 2013-02-07 | 2022-04-06 | Shanghai Golden Leaf Med Tec Co., Ltd | Radio frequency ablation method, system and radio frequency ablation device thereof |
US10076384B2 (en) | 2013-03-08 | 2018-09-18 | Symple Surgical, Inc. | Balloon catheter apparatus with microwave emitter |
US9179974B2 (en) | 2013-03-15 | 2015-11-10 | Medtronic Ardian Luxembourg S.A.R.L. | Helical push wire electrode |
US9872719B2 (en) | 2013-07-24 | 2018-01-23 | Covidien Lp | Systems and methods for generating electrosurgical energy using a multistage power converter |
US9655670B2 (en) | 2013-07-29 | 2017-05-23 | Covidien Lp | Systems and methods for measuring tissue impedance through an electrosurgical cable |
US20150073515A1 (en) | 2013-09-09 | 2015-03-12 | Medtronic Ardian Luxembourg S.a.r.I. | Neuromodulation Catheter Devices and Systems Having Energy Delivering Thermocouple Assemblies and Associated Methods |
US9622811B2 (en) | 2014-02-21 | 2017-04-18 | Warsaw Orthopedic, Inc. | Surgical instrument and method |
WO2015164280A1 (en) | 2014-04-24 | 2015-10-29 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation catheters having braided shafts and associated systems and methods |
US10016234B2 (en) * | 2014-06-05 | 2018-07-10 | St. Jude Medical, Cardiology Division, Inc. | Flex tip fluid lumen assembly with thermal sensor |
GB201418474D0 (en) * | 2014-10-17 | 2014-12-03 | Creo Medical Ltd | Electrosurgical apparatus |
GB201418486D0 (en) * | 2014-10-17 | 2014-12-03 | Creo Medical Ltd | Cable for conveying radiofrequency and/or microwave frequency energy to an electrosurgical instrument |
US20180153436A1 (en) | 2015-06-03 | 2018-06-07 | St. Jude Medical International Holding S.À R.L. | Active magnetic position sensor |
US10751123B2 (en) | 2015-10-30 | 2020-08-25 | Washington University | Thermoablation probe |
ES2581127B2 (en) * | 2016-04-13 | 2017-05-04 | Universidad Complutense De Madrid | Label, system and method for long-distance object detection |
GB2550414A (en) * | 2016-05-20 | 2017-11-22 | Creo Medical Ltd | Antenna structure |
GB2559604A (en) * | 2017-02-13 | 2018-08-15 | Creo Medical Ltd | Microwave energy transfer component for electrosurgical apparatus |
CN110381870B (en) * | 2017-03-01 | 2023-12-26 | I.C.医疗股份有限公司 | Super-polar telescopic and non-telescopic electrosurgical pencil and super-polar electrosurgical blade assembly with argon beam capability |
US10751507B2 (en) * | 2017-04-10 | 2020-08-25 | Syn Variflex, Llc | Thermally controlled variable-flexibility catheters and methods of manufacturing same |
GB201708726D0 (en) * | 2017-06-01 | 2017-07-19 | Creo Medical Ltd | Electrosurgical instrument for ablation and resection |
GB2563386A (en) * | 2017-06-08 | 2018-12-19 | Creo Medical Ltd | Electrosurgical instrument |
CN107349010A (en) * | 2017-07-07 | 2017-11-17 | 昆山雷盛医疗科技有限公司 | Radio frequency ablation probe and preparation method thereof |
CN109464186B (en) | 2017-09-08 | 2023-12-22 | 泽丹医疗股份有限公司 | Device and method for treating lung tumors |
WO2019094090A1 (en) * | 2017-11-13 | 2019-05-16 | Cryterion Medical, Inc. | Operator preference storage system for intravascular catheter system |
WO2019245746A1 (en) * | 2018-06-21 | 2019-12-26 | Shockwave Medical, Inc. | System for treating occlusions in body lumens |
KR20210075104A (en) | 2018-10-06 | 2021-06-22 | 사이맵 메디컬 (쑤저우), 엘티디 | Systems and methods for mapping functional nerves neurostimulating arterial walls, 3-D mapping and catheters therefor |
US20210128231A1 (en) * | 2019-11-04 | 2021-05-06 | Medwaves, Inc. | Energy transmitting therapeutic medical device |
AU2020391498B2 (en) * | 2019-11-27 | 2023-08-17 | Blossom Innovations, LLC | Devices, systems and methods for tissue analysis, location determination and tissue ablation |
CN110870791B (en) * | 2019-12-04 | 2021-09-03 | 上海微创电生理医疗科技股份有限公司 | Medical intervention needle assembly and medical intervention catheter |
Citations (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3309455A (en) * | 1964-09-21 | 1967-03-14 | Dow Chemical Co | Coaxial cable with insulating conductor supporting layers bonded to the conductors |
US4408089A (en) * | 1979-11-16 | 1983-10-04 | Nixon Charles E | Extremely low-attenuation, extremely low radiation loss flexible coaxial cable for microwave energy in the gigaHertz frequency range |
US4583556A (en) * | 1982-12-13 | 1986-04-22 | M/A-Com, Inc. | Microwave applicator/receiver apparatus |
US4776086A (en) * | 1986-02-27 | 1988-10-11 | Kasevich Associates, Inc. | Method and apparatus for hyperthermia treatment |
US5150717A (en) * | 1988-11-10 | 1992-09-29 | Arye Rosen | Microwave aided balloon angioplasty with guide filament |
US5370644A (en) * | 1988-11-25 | 1994-12-06 | Sensor Electronics, Inc. | Radiofrequency ablation catheter |
US5500012A (en) * | 1992-07-15 | 1996-03-19 | Angeion Corporation | Ablation catheter system |
US5540681A (en) * | 1992-04-10 | 1996-07-30 | Medtronic Cardiorhythm | Method and system for radiofrequency ablation of tissue |
US5617854A (en) * | 1994-06-22 | 1997-04-08 | Munsif; Anand | Shaped catheter device and method |
US5642736A (en) * | 1992-02-14 | 1997-07-01 | Avitall; Boaz | Biplanar deflectable catheter for arrhythmogenic tissue ablation |
US5656029A (en) * | 1992-12-01 | 1997-08-12 | Cardiac Pathways Corporation | Steerable catheter with adjustable bend location and/or radius and method |
US5683382A (en) * | 1995-05-15 | 1997-11-04 | Arrow International Investment Corp. | Microwave antenna catheter |
US5702433A (en) * | 1995-06-27 | 1997-12-30 | Arrow International Investment Corp. | Kink-resistant steerable catheter assembly for microwave ablation |
US5738683A (en) * | 1994-07-16 | 1998-04-14 | Osypka; Peter | Mapping and ablation catheter |
US5741249A (en) * | 1996-10-16 | 1998-04-21 | Fidus Medical Technology Corporation | Anchoring tip assembly for microwave ablation catheter |
US5776176A (en) * | 1996-06-17 | 1998-07-07 | Urologix Inc. | Microwave antenna for arterial for arterial microwave applicator |
US5842984A (en) * | 1993-12-03 | 1998-12-01 | Avitall; Boaz | Mapping and ablation catheter system with locking mechanism |
US5849028A (en) * | 1997-05-16 | 1998-12-15 | Irvine Biomedical, Inc. | Catheter and method for radiofrequency ablation of cardiac tissue |
US5863291A (en) * | 1996-04-08 | 1999-01-26 | Cardima, Inc. | Linear ablation assembly |
US5882333A (en) * | 1994-05-13 | 1999-03-16 | Cardima, Inc. | Catheter with deflectable distal section |
US5902251A (en) * | 1996-05-06 | 1999-05-11 | Vanhooydonk; Neil C. | Transcervical intrauterine applicator for intrauterine hyperthermia |
US5957969A (en) * | 1993-05-14 | 1999-09-28 | Fidus Medical Technology Corporation | Tunable microwave ablation catheter system and method |
US6014579A (en) * | 1997-07-21 | 2000-01-11 | Cardiac Pathways Corp. | Endocardial mapping catheter with movable electrode |
US6033403A (en) * | 1998-10-08 | 2000-03-07 | Irvine Biomedical, Inc. | Long electrode catheter system and methods thereof |
US6071280A (en) * | 1993-11-08 | 2000-06-06 | Rita Medical Systems, Inc. | Multiple electrode ablation apparatus |
US6123718A (en) * | 1998-11-02 | 2000-09-26 | Polymerex Medical Corp. | Balloon catheter |
US6190382B1 (en) * | 1998-12-14 | 2001-02-20 | Medwaves, Inc. | Radio-frequency based catheter system for ablation of body tissues |
US20010018596A1 (en) * | 1997-02-28 | 2001-08-30 | Selmon Matthew R. | Methods and apparatus for treating vascular occlusions |
US6319250B1 (en) * | 1998-11-23 | 2001-11-20 | C.R. Bard, Inc | Tricuspid annular grasp catheter |
US6383182B1 (en) * | 1998-10-23 | 2002-05-07 | Afx Inc. | Directional microwave ablation instrument with off-set energy delivery portion |
US20020087151A1 (en) * | 2000-12-29 | 2002-07-04 | Afx, Inc. | Tissue ablation apparatus with a sliding ablation instrument and method |
US6527769B2 (en) * | 1998-03-02 | 2003-03-04 | Atrionix, Inc. | Tissue ablation system and method for forming long linear lesion |
US6592581B2 (en) * | 1998-05-05 | 2003-07-15 | Cardiac Pacemakers, Inc. | Preformed steerable catheter with movable outer sleeve and method for use |
US6610058B2 (en) * | 2001-05-02 | 2003-08-26 | Cardiac Pacemakers, Inc. | Dual-profile steerable catheter |
US6669692B1 (en) * | 2000-08-21 | 2003-12-30 | Biosense Webster, Inc. | Ablation catheter with cooled linear electrode |
US20050055019A1 (en) * | 2003-09-05 | 2005-03-10 | Medtronic, Inc. | RF ablation catheter including a virtual electrode assembly |
US20050090880A1 (en) * | 2002-03-20 | 2005-04-28 | Fogazzi Di Venturelli Andrea &C. S.N.C. | Catheter with flexible cooled electrode |
US6941953B2 (en) * | 2003-02-20 | 2005-09-13 | Medwaves, Inc. | Preformed catheter set for use with a linear ablation system to produce ablation lines in the left and right atrium for treatment of atrial fibrillation |
US20050222563A1 (en) * | 2004-03-31 | 2005-10-06 | Mcdaniel Benjamin D | Catheter for circumferential ablation at or near a pulmonary vein |
US7004938B2 (en) * | 2001-11-29 | 2006-02-28 | Medwaves, Inc. | Radio-frequency-based catheter system with improved deflection and steering mechanisms |
US7070595B2 (en) * | 1998-12-14 | 2006-07-04 | Medwaves, Inc. | Radio-frequency based catheter system and method for ablating biological tissues |
US7229450B1 (en) * | 2003-02-11 | 2007-06-12 | Pacesetter, Inc. | Kink resistant introducer with mapping capabilities |
US20090082762A1 (en) * | 2007-09-20 | 2009-03-26 | Ormsby Theodore C | Radio frequency energy transmission device for the ablation of biological tissues |
US7594913B2 (en) * | 1998-12-14 | 2009-09-29 | Medwaves, Inc. | Radio-frequency based catheter system and method for ablating biological tissues |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US595796A (en) | 1897-12-21 | Wrench | ||
US2847990A (en) | 1956-03-20 | 1958-08-19 | Ayre James Ernest | Instrument for obtaining cells for cytodiagnosis |
US3058473A (en) | 1959-11-27 | 1962-10-16 | Alfred E Whitchead | Remotely directing catheters and tools |
US3552384A (en) | 1967-07-03 | 1971-01-05 | American Hospital Supply Corp | Controllable tip guide body and catheter |
US3521620A (en) | 1967-10-30 | 1970-07-28 | William A Cook | Vascular coil spring guide with bendable tip |
US4204549A (en) * | 1977-12-12 | 1980-05-27 | Rca Corporation | Coaxial applicator for microwave hyperthermia |
US4271848A (en) * | 1979-01-11 | 1981-06-09 | Bio Systems Design, Corp. | Apparatus for electromagnetic radiation of living tissue and the like |
US5370675A (en) * | 1992-08-12 | 1994-12-06 | Vidamed, Inc. | Medical probe device and method |
US4723936A (en) | 1986-07-22 | 1988-02-09 | Versaflex Delivery Systems Inc. | Steerable catheter |
US4906230A (en) | 1987-06-30 | 1990-03-06 | Baxter Travenol Laboratories, Inc. | Steerable catheter tip |
US4960134A (en) | 1988-11-18 | 1990-10-02 | Webster Wilton W Jr | Steerable catheter |
JPH05506174A (en) | 1990-09-14 | 1993-09-16 | アメリカン・メディカル・システムズ・インコーポレーテッド | Combined hyperthermia and dilatation catheter |
US5413588A (en) | 1992-03-06 | 1995-05-09 | Urologix, Inc. | Device and method for asymmetrical thermal therapy with helical dipole microwave antenna |
US5370677A (en) * | 1992-03-06 | 1994-12-06 | Urologix, Inc. | Gamma matched, helical dipole microwave antenna with tubular-shaped capacitor |
US5275597A (en) * | 1992-05-18 | 1994-01-04 | Baxter International Inc. | Percutaneous transluminal catheter and transmitter therefor |
JP2586174Y2 (en) * | 1992-07-30 | 1998-12-02 | キム ジョン イル | Cigarette type gas lighter |
US5298682A (en) | 1992-08-20 | 1994-03-29 | Wireworld By David Salz, Inc. | Optimized symmetrical coaxial cable |
US6161543A (en) | 1993-02-22 | 2000-12-19 | Epicor, Inc. | Methods of epicardial ablation for creating a lesion around the pulmonary veins |
US5476495A (en) | 1993-03-16 | 1995-12-19 | Ep Technologies, Inc. | Cardiac mapping and ablation systems |
US5656796A (en) | 1993-04-26 | 1997-08-12 | Fmc Corp. | High energy flexible coaxial cable and connections |
US5545193A (en) | 1993-10-15 | 1996-08-13 | Ep Technologies, Inc. | Helically wound radio-frequency emitting electrodes for creating lesions in body tissue |
US5462545A (en) | 1994-01-31 | 1995-10-31 | New England Medical Center Hospitals, Inc. | Catheter electrodes |
US5885278A (en) | 1994-10-07 | 1999-03-23 | E.P. Technologies, Inc. | Structures for deploying movable electrode elements |
US5857997A (en) | 1994-11-14 | 1999-01-12 | Heart Rhythm Technologies, Inc. | Catheter for electrophysiological procedures |
US5697958A (en) * | 1995-06-07 | 1997-12-16 | Intermedics, Inc. | Electromagnetic noise detector for implantable medical devices |
CA2224589C (en) | 1995-06-12 | 2007-05-08 | Cordis Webster, Inc. | Catheter with an electromagnetic guidance sensor |
US5788692A (en) | 1995-06-30 | 1998-08-04 | Fidus Medical Technology Corporation | Mapping ablation catheter |
US5810717A (en) | 1995-09-22 | 1998-09-22 | Mitsubishi Cable Industries, Ltd. | Bending mechanism and stereoscope using same |
US5837001A (en) | 1995-12-08 | 1998-11-17 | C. R. Bard | Radio frequency energy delivery system for multipolar electrode catheters |
US6032077A (en) | 1996-03-06 | 2000-02-29 | Cardiac Pathways Corporation | Ablation catheter with electrical coupling via foam drenched with a conductive fluid |
US5800482A (en) | 1996-03-06 | 1998-09-01 | Cardiac Pathways Corporation | Apparatus and method for linear lesion ablation |
US5755760A (en) | 1996-03-11 | 1998-05-26 | Medtronic, Inc. | Deflectable catheter |
US5904709A (en) * | 1996-04-17 | 1999-05-18 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Microwave treatment for cardiac arrhythmias |
US5752951A (en) | 1996-07-02 | 1998-05-19 | Yanik; Gary W. | Shielded monopolar electrosurgical apparatus |
US5800494A (en) | 1996-08-20 | 1998-09-01 | Fidus Medical Technology Corporation | Microwave ablation catheters having antennas with distal fire capabilities |
US5893885A (en) | 1996-11-01 | 1999-04-13 | Cordis Webster, Inc. | Multi-electrode ablation catheter |
US5785706A (en) | 1996-11-18 | 1998-07-28 | Daig Corporation | Nonsurgical mapping and treatment of cardiac arrhythmia using a catheter contained within a guiding introducer containing openings |
US5904667A (en) | 1997-03-17 | 1999-05-18 | C.R. Bard, Inc. | Rotatable control mechanism for steerable catheter |
US5876373A (en) | 1997-04-04 | 1999-03-02 | Eclipse Surgical Technologies, Inc. | Steerable catheter |
US5971983A (en) | 1997-05-09 | 1999-10-26 | The Regents Of The University Of California | Tissue ablation device and method of use |
US6123699A (en) | 1997-09-05 | 2000-09-26 | Cordis Webster, Inc. | Omni-directional steerable catheter |
US5897529A (en) | 1997-09-05 | 1999-04-27 | Cordis Webster, Inc. | Steerable deflectable catheter having improved flexibility |
US6183463B1 (en) | 1997-12-01 | 2001-02-06 | Cordis Webster, Inc. | Bidirectional steerable cathether with bidirectional control handle |
US6067475A (en) | 1998-11-05 | 2000-05-23 | Urologix, Inc. | Microwave energy delivery system including high performance dual directional coupler for precisely measuring forward and reverse microwave power during thermal therapy |
US20070066972A1 (en) | 2001-11-29 | 2007-03-22 | Medwaves, Inc. | Ablation catheter apparatus with one or more electrodes |
US6267746B1 (en) | 1999-03-22 | 2001-07-31 | Biosense Webster, Inc. | Multi-directional steerable catheters and control handles |
US6610046B1 (en) | 1999-04-30 | 2003-08-26 | Usaminanotechnology Inc. | Catheter and guide wire |
GB9912625D0 (en) | 1999-05-28 | 1999-07-28 | Gyrus Medical Ltd | An electrosurgical generator and system |
US6277113B1 (en) | 1999-05-28 | 2001-08-21 | Afx, Inc. | Monopole tip for ablation catheter and methods for using same |
US20010007940A1 (en) | 1999-06-21 | 2001-07-12 | Hosheng Tu | Medical device having ultrasound imaging and therapeutic means |
US6254568B1 (en) | 1999-08-10 | 2001-07-03 | Biosense Webster, Inc. | Deflectable catheter with straightening element |
US6230060B1 (en) * | 1999-10-22 | 2001-05-08 | Daniel D. Mawhinney | Single integrated structural unit for catheter incorporating a microwave antenna |
US7033352B1 (en) | 2000-01-18 | 2006-04-25 | Afx, Inc. | Flexible ablation instrument |
US6663622B1 (en) | 2000-02-11 | 2003-12-16 | Iotek, Inc. | Surgical devices and methods for use in tissue ablation procedures |
US6673068B1 (en) | 2000-04-12 | 2004-01-06 | Afx, Inc. | Electrode arrangement for use in a medical instrument |
US6582536B2 (en) | 2000-04-24 | 2003-06-24 | Biotran Corporation Inc. | Process for producing steerable sheath catheters |
US6475214B1 (en) | 2000-05-01 | 2002-11-05 | Biosense Webster, Inc. | Catheter with enhanced ablation electrode |
EP1151728B1 (en) | 2000-05-03 | 2006-08-02 | Joshua Dr. Friedman | Method and heating assembly for preheating dental materials |
JP3521253B2 (en) | 2000-05-18 | 2004-04-19 | 株式会社東北テクノアーチ | Shape memory alloy for living body |
US6893155B2 (en) | 2000-09-30 | 2005-05-17 | Dolores C. Kaiser | Cooking thermometer with audible alarm |
US6878147B2 (en) | 2001-11-02 | 2005-04-12 | Vivant Medical, Inc. | High-strength microwave antenna assemblies |
US7194297B2 (en) | 2001-11-13 | 2007-03-20 | Boston Scientific Scimed, Inc. | Impedance-matching apparatus and construction for intravascular device |
US6706040B2 (en) * | 2001-11-23 | 2004-03-16 | Medlennium Technologies, Inc. | Invasive therapeutic probe |
WO2003049514A2 (en) | 2001-12-03 | 2003-06-12 | Memgen Corporation | Miniature rf and microwave components and methods for fabricating such components |
US6907298B2 (en) | 2002-01-09 | 2005-06-14 | Medtronic, Inc. | Method and apparatus for imparting curves in implantable elongated medical instruments |
WO2004030718A2 (en) | 2002-09-20 | 2004-04-15 | Flowmedica, Inc. | Method and apparatus for intra aortic substance delivery to a branch vessel |
US7736362B2 (en) | 2003-09-15 | 2010-06-15 | Boston Scientific Scimed, Inc. | Catheter balloons |
US7331959B2 (en) | 2004-05-27 | 2008-02-19 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Catheter electrode and rail system for cardiac ablation |
-
2006
- 2006-10-19 US US11/551,162 patent/US20070066972A1/en not_active Abandoned
-
2007
- 2007-07-23 US US11/781,467 patent/US8308722B2/en not_active Expired - Fee Related
- 2007-10-09 ES ES07853876.6T patent/ES2546754T3/en active Active
- 2007-10-09 WO PCT/US2007/080819 patent/WO2008051708A2/en active Application Filing
- 2007-10-09 EP EP07853876.6A patent/EP2073738B1/en active Active
- 2007-10-09 CN CN2007800389107A patent/CN101534737B/en active Active
Patent Citations (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3309455A (en) * | 1964-09-21 | 1967-03-14 | Dow Chemical Co | Coaxial cable with insulating conductor supporting layers bonded to the conductors |
US4408089A (en) * | 1979-11-16 | 1983-10-04 | Nixon Charles E | Extremely low-attenuation, extremely low radiation loss flexible coaxial cable for microwave energy in the gigaHertz frequency range |
US4583556A (en) * | 1982-12-13 | 1986-04-22 | M/A-Com, Inc. | Microwave applicator/receiver apparatus |
US4776086A (en) * | 1986-02-27 | 1988-10-11 | Kasevich Associates, Inc. | Method and apparatus for hyperthermia treatment |
US5150717A (en) * | 1988-11-10 | 1992-09-29 | Arye Rosen | Microwave aided balloon angioplasty with guide filament |
US5370644A (en) * | 1988-11-25 | 1994-12-06 | Sensor Electronics, Inc. | Radiofrequency ablation catheter |
US5642736A (en) * | 1992-02-14 | 1997-07-01 | Avitall; Boaz | Biplanar deflectable catheter for arrhythmogenic tissue ablation |
US5540681A (en) * | 1992-04-10 | 1996-07-30 | Medtronic Cardiorhythm | Method and system for radiofrequency ablation of tissue |
US5500012A (en) * | 1992-07-15 | 1996-03-19 | Angeion Corporation | Ablation catheter system |
US5656029A (en) * | 1992-12-01 | 1997-08-12 | Cardiac Pathways Corporation | Steerable catheter with adjustable bend location and/or radius and method |
US5957969A (en) * | 1993-05-14 | 1999-09-28 | Fidus Medical Technology Corporation | Tunable microwave ablation catheter system and method |
US6071280A (en) * | 1993-11-08 | 2000-06-06 | Rita Medical Systems, Inc. | Multiple electrode ablation apparatus |
US5842984A (en) * | 1993-12-03 | 1998-12-01 | Avitall; Boaz | Mapping and ablation catheter system with locking mechanism |
US5882333A (en) * | 1994-05-13 | 1999-03-16 | Cardima, Inc. | Catheter with deflectable distal section |
US5617854A (en) * | 1994-06-22 | 1997-04-08 | Munsif; Anand | Shaped catheter device and method |
US5738683A (en) * | 1994-07-16 | 1998-04-14 | Osypka; Peter | Mapping and ablation catheter |
US5683382A (en) * | 1995-05-15 | 1997-11-04 | Arrow International Investment Corp. | Microwave antenna catheter |
US5702433A (en) * | 1995-06-27 | 1997-12-30 | Arrow International Investment Corp. | Kink-resistant steerable catheter assembly for microwave ablation |
US5863291A (en) * | 1996-04-08 | 1999-01-26 | Cardima, Inc. | Linear ablation assembly |
US5902251A (en) * | 1996-05-06 | 1999-05-11 | Vanhooydonk; Neil C. | Transcervical intrauterine applicator for intrauterine hyperthermia |
US5776176A (en) * | 1996-06-17 | 1998-07-07 | Urologix Inc. | Microwave antenna for arterial for arterial microwave applicator |
US5741249A (en) * | 1996-10-16 | 1998-04-21 | Fidus Medical Technology Corporation | Anchoring tip assembly for microwave ablation catheter |
US20010018596A1 (en) * | 1997-02-28 | 2001-08-30 | Selmon Matthew R. | Methods and apparatus for treating vascular occlusions |
US5849028A (en) * | 1997-05-16 | 1998-12-15 | Irvine Biomedical, Inc. | Catheter and method for radiofrequency ablation of cardiac tissue |
US6014579A (en) * | 1997-07-21 | 2000-01-11 | Cardiac Pathways Corp. | Endocardial mapping catheter with movable electrode |
US6527769B2 (en) * | 1998-03-02 | 2003-03-04 | Atrionix, Inc. | Tissue ablation system and method for forming long linear lesion |
US6592581B2 (en) * | 1998-05-05 | 2003-07-15 | Cardiac Pacemakers, Inc. | Preformed steerable catheter with movable outer sleeve and method for use |
US6033403A (en) * | 1998-10-08 | 2000-03-07 | Irvine Biomedical, Inc. | Long electrode catheter system and methods thereof |
US6383182B1 (en) * | 1998-10-23 | 2002-05-07 | Afx Inc. | Directional microwave ablation instrument with off-set energy delivery portion |
US6123718A (en) * | 1998-11-02 | 2000-09-26 | Polymerex Medical Corp. | Balloon catheter |
US6319250B1 (en) * | 1998-11-23 | 2001-11-20 | C.R. Bard, Inc | Tricuspid annular grasp catheter |
US7070595B2 (en) * | 1998-12-14 | 2006-07-04 | Medwaves, Inc. | Radio-frequency based catheter system and method for ablating biological tissues |
US6190382B1 (en) * | 1998-12-14 | 2001-02-20 | Medwaves, Inc. | Radio-frequency based catheter system for ablation of body tissues |
US7594913B2 (en) * | 1998-12-14 | 2009-09-29 | Medwaves, Inc. | Radio-frequency based catheter system and method for ablating biological tissues |
US6663625B1 (en) * | 1998-12-14 | 2003-12-16 | Theodore C. Ormsby | Radio-frequency based catheter system and hollow co-axial cable for ablation of body tissues |
US6669692B1 (en) * | 2000-08-21 | 2003-12-30 | Biosense Webster, Inc. | Ablation catheter with cooled linear electrode |
US20020087151A1 (en) * | 2000-12-29 | 2002-07-04 | Afx, Inc. | Tissue ablation apparatus with a sliding ablation instrument and method |
US6610058B2 (en) * | 2001-05-02 | 2003-08-26 | Cardiac Pacemakers, Inc. | Dual-profile steerable catheter |
US7004938B2 (en) * | 2001-11-29 | 2006-02-28 | Medwaves, Inc. | Radio-frequency-based catheter system with improved deflection and steering mechanisms |
US20050090880A1 (en) * | 2002-03-20 | 2005-04-28 | Fogazzi Di Venturelli Andrea &C. S.N.C. | Catheter with flexible cooled electrode |
US7229450B1 (en) * | 2003-02-11 | 2007-06-12 | Pacesetter, Inc. | Kink resistant introducer with mapping capabilities |
US6941953B2 (en) * | 2003-02-20 | 2005-09-13 | Medwaves, Inc. | Preformed catheter set for use with a linear ablation system to produce ablation lines in the left and right atrium for treatment of atrial fibrillation |
US20050055019A1 (en) * | 2003-09-05 | 2005-03-10 | Medtronic, Inc. | RF ablation catheter including a virtual electrode assembly |
US20050222563A1 (en) * | 2004-03-31 | 2005-10-06 | Mcdaniel Benjamin D | Catheter for circumferential ablation at or near a pulmonary vein |
US20090082762A1 (en) * | 2007-09-20 | 2009-03-26 | Ormsby Theodore C | Radio frequency energy transmission device for the ablation of biological tissues |
Cited By (374)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080015570A1 (en) * | 1998-12-14 | 2008-01-17 | Ormsby Theodore C | Hollow conductive coaxial cable for radio frequency based tissue ablation system |
US8308722B2 (en) | 1998-12-14 | 2012-11-13 | Medwaves, Inc. | Hollow conductive coaxial cable for radio frequency based tissue ablation system |
US20060142752A1 (en) * | 2001-11-29 | 2006-06-29 | Ormsby Theodore C | Radio-frequency-based catheter system with improved deflection and steering mechanisms |
US8152799B2 (en) | 2001-11-29 | 2012-04-10 | Medwaves, Inc. | Radio frequency-based catheter system with improved deflection and steering mechanisms |
US20110009858A1 (en) * | 2001-11-29 | 2011-01-13 | Medwaves, Inc. | Radio frequency-based catheter system with improved deflection and steering mechanisms |
US7815637B2 (en) | 2001-11-29 | 2010-10-19 | Ormsby Theodore C | Radio-frequency-based catheter system with improved deflection and steering mechanisms |
US8818514B2 (en) | 2002-04-08 | 2014-08-26 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for intravascularly-induced neuromodulation |
US11033328B2 (en) | 2002-04-08 | 2021-06-15 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for renal neuromodulation |
US9439726B2 (en) | 2002-04-08 | 2016-09-13 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US9456869B2 (en) | 2002-04-08 | 2016-10-04 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for bilateral renal neuromodulation |
US9463066B2 (en) | 2002-04-08 | 2016-10-11 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for renal neuromodulation |
US9468497B2 (en) | 2002-04-08 | 2016-10-18 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
US9474563B2 (en) | 2002-04-08 | 2016-10-25 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for renal neuromodulation |
US9364280B2 (en) | 2002-04-08 | 2016-06-14 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach |
US9486270B2 (en) | 2002-04-08 | 2016-11-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for bilateral renal neuromodulation |
US9326817B2 (en) | 2002-04-08 | 2016-05-03 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for treating heart arrhythmia |
US9327122B2 (en) | 2002-04-08 | 2016-05-03 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
US9320561B2 (en) | 2002-04-08 | 2016-04-26 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for bilateral renal neuromodulation |
US9314630B2 (en) | 2002-04-08 | 2016-04-19 | Medtronic Ardian Luxembourg S.A.R.L. | Renal neuromodulation for treatment of patients |
US9308043B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
US9308044B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US9636174B2 (en) | 2002-04-08 | 2017-05-02 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US9289255B2 (en) | 2002-04-08 | 2016-03-22 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for renal neuromodulation |
US9675413B2 (en) | 2002-04-08 | 2017-06-13 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for renal neuromodulation |
US20070129760A1 (en) * | 2002-04-08 | 2007-06-07 | Ardian, Inc. | Methods and apparatus for intravasculary-induced neuromodulation or denervation |
US9265558B2 (en) | 2002-04-08 | 2016-02-23 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for bilateral renal neuromodulation |
US9707035B2 (en) | 2002-04-08 | 2017-07-18 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
US9731132B2 (en) | 2002-04-08 | 2017-08-15 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for renal neuromodulation |
US20060276852A1 (en) * | 2002-04-08 | 2006-12-07 | Ardian, Inc. | Methods and apparatus for treating hypertension |
US9743983B2 (en) | 2002-04-08 | 2017-08-29 | Medtronic Ardian Luxembourg S.A.R.L. | Renal neuromodulation for treatment of patients |
US9192715B2 (en) | 2002-04-08 | 2015-11-24 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for renal nerve blocking |
US9757193B2 (en) | 2002-04-08 | 2017-09-12 | Medtronic Ardian Luxembourg S.A.R.L. | Balloon catheter apparatus for renal neuromodulation |
US9757192B2 (en) | 2002-04-08 | 2017-09-12 | Medtronic Ardian Luxembourg S.A.R.L. | Renal neuromodulation for treatment of patients |
US20110208096A1 (en) * | 2002-04-08 | 2011-08-25 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
US9186213B2 (en) | 2002-04-08 | 2015-11-17 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for renal neuromodulation |
US9186198B2 (en) | 2002-04-08 | 2015-11-17 | Medtronic Ardian Luxembourg S.A.R.L. | Ultrasound apparatuses for thermally-induced renal neuromodulation and associated systems and methods |
US9814873B2 (en) | 2002-04-08 | 2017-11-14 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for bilateral renal neuromodulation |
US8131372B2 (en) | 2002-04-08 | 2012-03-06 | Ardian, Inc. | Renal nerve stimulation method for treatment of patients |
US8131371B2 (en) | 2002-04-08 | 2012-03-06 | Ardian, Inc. | Methods and apparatus for monopolar renal neuromodulation |
US9827041B2 (en) | 2002-04-08 | 2017-11-28 | Medtronic Ardian Luxembourg S.A.R.L. | Balloon catheter apparatuses for renal denervation |
US8145317B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods for renal neuromodulation |
US8145316B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US8150519B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
US8150520B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods for catheter-based renal denervation |
US8150518B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Renal nerve stimulation method and apparatus for treatment of patients |
US20060265014A1 (en) * | 2002-04-08 | 2006-11-23 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
US10376516B2 (en) | 2002-04-08 | 2019-08-13 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and devices for renal nerve blocking |
US9827040B2 (en) | 2002-04-08 | 2017-11-28 | Medtronic Adrian Luxembourg S.a.r.l. | Methods and apparatus for intravascularly-induced neuromodulation |
US8175711B2 (en) | 2002-04-08 | 2012-05-08 | Ardian, Inc. | Methods for treating a condition or disease associated with cardio-renal function |
US9895195B2 (en) | 2002-04-08 | 2018-02-20 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US8852163B2 (en) | 2002-04-08 | 2014-10-07 | Medtronic Ardian Luxembourg S.A.R.L. | Renal neuromodulation via drugs and neuromodulatory agents and associated systems and methods |
US20060265015A1 (en) * | 2002-04-08 | 2006-11-23 | Ardian, Inc. | Methods and apparatus for monopolar renal neuromodulation |
US9131978B2 (en) | 2002-04-08 | 2015-09-15 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for bilateral renal neuromodulation |
US9125661B2 (en) | 2002-04-08 | 2015-09-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for renal neuromodulation |
US9907611B2 (en) | 2002-04-08 | 2018-03-06 | Medtronic Ardian Luxembourg S.A.R.L. | Renal neuromodulation for treatment of patients |
US8454594B2 (en) | 2002-04-08 | 2013-06-04 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatus for performing a non-continuous circumferential treatment of a body lumen |
US9956410B2 (en) | 2002-04-08 | 2018-05-01 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for renal neuromodulation |
US8880186B2 (en) | 2002-04-08 | 2014-11-04 | Medtronic Ardian Luxembourg S.A.R.L. | Renal neuromodulation for treatment of patients with chronic heart failure |
US9968611B2 (en) | 2002-04-08 | 2018-05-15 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and devices for renal nerve blocking |
US8548600B2 (en) | 2002-04-08 | 2013-10-01 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatuses for renal neuromodulation and associated systems and methods |
US8551069B2 (en) | 2002-04-08 | 2013-10-08 | Medtronic Adrian Luxembourg S.a.r.l. | Methods and apparatus for treating contrast nephropathy |
US8620423B2 (en) | 2002-04-08 | 2013-12-31 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for thermal modulation of nerves contributing to renal function |
US8626300B2 (en) | 2002-04-08 | 2014-01-07 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for thermally-induced renal neuromodulation |
US20060041277A1 (en) * | 2002-04-08 | 2006-02-23 | Mark Deem | Methods and apparatus for renal neuromodulation |
US9072527B2 (en) | 2002-04-08 | 2015-07-07 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatuses and methods for renal neuromodulation |
US10441356B2 (en) | 2002-04-08 | 2019-10-15 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for renal neuromodulation via neuromodulatory agents |
US10034708B2 (en) | 2002-04-08 | 2018-07-31 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for thermally-induced renal neuromodulation |
US8684998B2 (en) | 2002-04-08 | 2014-04-01 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for inhibiting renal nerve activity |
US8721637B2 (en) | 2002-04-08 | 2014-05-13 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for performing renal neuromodulation via catheter apparatuses having inflatable balloons |
US8728137B2 (en) | 2002-04-08 | 2014-05-20 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for thermally-induced renal neuromodulation |
US8728138B2 (en) | 2002-04-08 | 2014-05-20 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for thermally-induced renal neuromodulation |
US10420606B2 (en) | 2002-04-08 | 2019-09-24 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen |
US8740896B2 (en) | 2002-04-08 | 2014-06-03 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for performing renal neuromodulation via catheter apparatuses having inflatable balloons |
US8768470B2 (en) | 2002-04-08 | 2014-07-01 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monitoring renal neuromodulation |
US8774922B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods |
US8771252B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and devices for renal nerve blocking |
US8774913B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for intravasculary-induced neuromodulation |
US10039596B2 (en) | 2002-04-08 | 2018-08-07 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatus for renal neuromodulation via an intra-to-extravascular approach |
US8784463B2 (en) | 2002-04-08 | 2014-07-22 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for thermally-induced renal neuromodulation |
US10105180B2 (en) | 2002-04-08 | 2018-10-23 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for intravascularly-induced neuromodulation |
US10111707B2 (en) | 2002-04-08 | 2018-10-30 | Medtronic Ardian Luxembourg S.A.R.L. | Renal neuromodulation for treatment of human patients |
US10376311B2 (en) | 2002-04-08 | 2019-08-13 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for intravascularly-induced neuromodulation |
US9445867B1 (en) | 2002-04-08 | 2016-09-20 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for renal neuromodulation via catheters having expandable treatment members |
US8845629B2 (en) | 2002-04-08 | 2014-09-30 | Medtronic Ardian Luxembourg S.A.R.L. | Ultrasound apparatuses for thermally-induced renal neuromodulation |
US9138281B2 (en) | 2002-04-08 | 2015-09-22 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for bilateral renal neuromodulation via catheter apparatuses having expandable baskets |
US10124195B2 (en) | 2002-04-08 | 2018-11-13 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for thermally-induced renal neuromodulation |
US10850091B2 (en) | 2002-04-08 | 2020-12-01 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for bilateral renal neuromodulation |
US10376312B2 (en) | 2002-04-08 | 2019-08-13 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for monopolar renal neuromodulation |
US10130792B2 (en) | 2002-04-08 | 2018-11-20 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation using neuromodulatory agents or drugs |
US10179028B2 (en) | 2002-04-08 | 2019-01-15 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for treating patients via renal neuromodulation |
US9023037B2 (en) | 2002-04-08 | 2015-05-05 | Medtronic Ardian Luxembourg S.A.R.L. | Balloon catheter apparatus for renal neuromodulation |
US8934978B2 (en) | 2002-04-08 | 2015-01-13 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for renal neuromodulation |
US10179235B2 (en) | 2002-04-08 | 2019-01-15 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for bilateral renal neuromodulation |
US10179027B2 (en) | 2002-04-08 | 2019-01-15 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses having expandable baskets for renal neuromodulation and associated systems and methods |
US8948865B2 (en) | 2002-04-08 | 2015-02-03 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for treating heart arrhythmia |
US10293190B2 (en) | 2002-04-08 | 2019-05-21 | Medtronic Ardian Luxembourg S.A.R.L. | Thermally-induced renal neuromodulation and associated systems and methods |
US10272246B2 (en) | 2002-04-08 | 2019-04-30 | Medtronic Adrian Luxembourg S.a.r.l | Methods for extravascular renal neuromodulation |
US8958871B2 (en) | 2002-04-08 | 2015-02-17 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach |
US10245429B2 (en) | 2002-04-08 | 2019-04-02 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for renal neuromodulation |
US8986294B2 (en) | 2002-04-08 | 2015-03-24 | Medtronic Ardian Luxembourg S.a.rl. | Apparatuses for thermally-induced renal neuromodulation |
US8983595B2 (en) | 2002-04-08 | 2015-03-17 | Medtronic Ardian Luxembourg S.A.R.L. | Renal neuromodulation for treatment of patients with chronic heart failure |
US9700372B2 (en) | 2002-07-01 | 2017-07-11 | Recor Medical, Inc. | Intraluminal methods of ablating nerve tissue |
US9707034B2 (en) | 2002-07-01 | 2017-07-18 | Recor Medical, Inc. | Intraluminal method and apparatus for ablating nerve tissue |
US9125666B2 (en) | 2003-09-12 | 2015-09-08 | Vessix Vascular, Inc. | Selectable eccentric remodeling and/or ablation of atherosclerotic material |
US10188457B2 (en) | 2003-09-12 | 2019-01-29 | Vessix Vascular, Inc. | Selectable eccentric remodeling and/or ablation |
US9510901B2 (en) | 2003-09-12 | 2016-12-06 | Vessix Vascular, Inc. | Selectable eccentric remodeling and/or ablation |
US8939970B2 (en) | 2004-09-10 | 2015-01-27 | Vessix Vascular, Inc. | Tuned RF energy and electrical tissue characterization for selective treatment of target tissues |
US9713730B2 (en) | 2004-09-10 | 2017-07-25 | Boston Scientific Scimed, Inc. | Apparatus and method for treatment of in-stent restenosis |
US9125667B2 (en) | 2004-09-10 | 2015-09-08 | Vessix Vascular, Inc. | System for inducing desirable temperature effects on body tissue |
US8805545B2 (en) | 2004-10-05 | 2014-08-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for multi-vessel renal neuromodulation |
US10537734B2 (en) | 2004-10-05 | 2020-01-21 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for multi-vessel renal neuromodulation |
US8433423B2 (en) | 2004-10-05 | 2013-04-30 | Ardian, Inc. | Methods for multi-vessel renal neuromodulation |
US9950161B2 (en) | 2004-10-05 | 2018-04-24 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for multi-vessel renal neuromodulation |
US9108040B2 (en) | 2004-10-05 | 2015-08-18 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for multi-vessel renal neuromodulation |
US9402992B2 (en) | 2004-10-05 | 2016-08-02 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for multi-vessel renal neuromodulation |
US9486355B2 (en) | 2005-05-03 | 2016-11-08 | Vessix Vascular, Inc. | Selective accumulation of energy with or without knowledge of tissue topography |
US10363092B2 (en) | 2006-03-24 | 2019-07-30 | Neuwave Medical, Inc. | Transmission line with heat transfer ability |
US9808300B2 (en) | 2006-05-02 | 2017-11-07 | Boston Scientific Scimed, Inc. | Control of arterial smooth muscle tone |
US11576722B2 (en) | 2006-07-14 | 2023-02-14 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US11389235B2 (en) | 2006-07-14 | 2022-07-19 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US10376314B2 (en) | 2006-07-14 | 2019-08-13 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US11576723B2 (en) | 2006-07-14 | 2023-02-14 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US11596474B2 (en) | 2006-07-14 | 2023-03-07 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US10413356B2 (en) | 2006-10-18 | 2019-09-17 | Boston Scientific Scimed, Inc. | System for inducing desirable temperature effects on body tissue |
US9974607B2 (en) | 2006-10-18 | 2018-05-22 | Vessix Vascular, Inc. | Inducing desirable temperature effects on body tissue |
US10213252B2 (en) | 2006-10-18 | 2019-02-26 | Vessix, Inc. | Inducing desirable temperature effects on body tissue |
US20090005771A1 (en) * | 2007-06-28 | 2009-01-01 | Chad Allen Lieber | Optical Pyrometric Catheter for Tissue Temperature Monitoring During Cardiac Ablation |
US7976537B2 (en) | 2007-06-28 | 2011-07-12 | Biosense Webster, Inc. | Optical pyrometric catheter for tissue temperature monitoring during cardiac ablation |
US20090005773A1 (en) * | 2007-06-29 | 2009-01-01 | Christopher Beeckler | Ablation catheter with optically transparent, electrically conductive tip |
EP2008603A1 (en) * | 2007-06-29 | 2008-12-31 | Biosense Webster, Inc. | Ablation catheter with optically transparent electricity conductive tip |
US8123745B2 (en) * | 2007-06-29 | 2012-02-28 | Biosense Webster, Inc. | Ablation catheter with optically transparent, electrically conductive tip |
US20090082762A1 (en) * | 2007-09-20 | 2009-03-26 | Ormsby Theodore C | Radio frequency energy transmission device for the ablation of biological tissues |
US8353907B2 (en) * | 2007-12-21 | 2013-01-15 | Atricure, Inc. | Ablation device with internally cooled electrodes |
US20090163905A1 (en) * | 2007-12-21 | 2009-06-25 | Winkler Matthew J | Ablation device with internally cooled electrodes |
US20090163916A1 (en) * | 2007-12-21 | 2009-06-25 | Saurav Paul | Flexible Conductive Polymer Electrode and Method for Ablation |
US20140025058A1 (en) * | 2007-12-21 | 2014-01-23 | Matthew J. Winkler | Ablation device with internally cooled electrodes |
US8118809B2 (en) * | 2007-12-21 | 2012-02-21 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Flexible conductive polymer electrode and method for ablation |
US8915878B2 (en) * | 2007-12-21 | 2014-12-23 | Atricure, Inc. | Ablation device with internally cooled electrodes |
WO2009082635A1 (en) * | 2007-12-21 | 2009-07-02 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Flexible conductive polymer electrode and method for ablation |
US8473029B2 (en) * | 2007-12-26 | 2013-06-25 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Catheter electrode that can simultaneously emit electrical energy and facilitate visualization by magnetic resonance imaging |
US20090171187A1 (en) * | 2007-12-26 | 2009-07-02 | Gerhart John P | Catheter electrode that can simultaneously emit electrical energy and facilitate visualization by magnetic resonance imaging |
US20120226143A1 (en) * | 2007-12-26 | 2012-09-06 | Gerhart John P | Catheter electrode that can simultaneously emit electrical energy and facilitate visualization by magnetic resonance imaging |
US8175679B2 (en) * | 2007-12-26 | 2012-05-08 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Catheter electrode that can simultaneously emit electrical energy and facilitate visualization by magnetic resonance imaging |
US9675410B2 (en) * | 2007-12-28 | 2017-06-13 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Flexible polymer electrode for MRI-guided positioning and radio frequency ablation |
US20090171188A1 (en) * | 2007-12-28 | 2009-07-02 | Saurav Paul | Flexible polymer electrode for mri-guided positioning and radio frequency ablation |
US11331136B2 (en) | 2007-12-28 | 2022-05-17 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Flexible polymer electrode for MRI-guided positioning and radio frequency ablation |
US20090299360A1 (en) * | 2008-05-28 | 2009-12-03 | Medwaves, Inc. | Tissue ablation apparatus and method using ultrasonic imaging |
US8133222B2 (en) | 2008-05-28 | 2012-03-13 | Medwaves, Inc. | Tissue ablation apparatus and method using ultrasonic imaging |
US8679106B2 (en) * | 2008-07-01 | 2014-03-25 | Medwaves, Inc. | Angioplasty and tissue ablation apparatus and method |
US20100004650A1 (en) * | 2008-07-01 | 2010-01-07 | Medwaves, Inc. | Angioplasty and tissue ablation apparatus and method |
US10299859B2 (en) | 2008-10-21 | 2019-05-28 | Microcube, Llc | Methods and devices for delivering microwave energy |
US11219484B2 (en) | 2008-10-21 | 2022-01-11 | Microcube, Llc | Methods and devices for delivering microwave energy |
US9615882B2 (en) | 2008-10-21 | 2017-04-11 | Microcube, Llc | Methods and devices for applying energy to bodily tissues |
US20100137857A1 (en) * | 2008-10-21 | 2010-06-03 | Microcube, Limited Liability Corporation | Methods and devices for applying energy to bodily tissues |
US20220249163A1 (en) * | 2008-10-21 | 2022-08-11 | Microcube, Llc | Microwave treatment devices and methods |
US20110004205A1 (en) * | 2008-10-21 | 2011-01-06 | Chu Chun Yiu | Methods and devices for delivering microwave energy |
US11684418B2 (en) | 2008-10-21 | 2023-06-27 | Microcube, Llc | Methods and devices for applying energy to bodily tissues |
US20100125269A1 (en) * | 2008-10-21 | 2010-05-20 | Microcube, Limited Liability Corporation | Microwave treatment devices and methods |
US11291503B2 (en) * | 2008-10-21 | 2022-04-05 | Microcube, Llc | Microwave treatment devices and methods |
EP2349452A4 (en) * | 2008-10-21 | 2012-09-05 | Microcube Llc | Microwave treatment devices and methods |
EP2349452A1 (en) * | 2008-10-21 | 2011-08-03 | Microcube, LLC | Microwave treatment devices and methods |
US10869720B2 (en) | 2008-10-21 | 2020-12-22 | Microcube, Llc | Methods and devices for applying energy to bodily tissues |
US9980774B2 (en) | 2008-10-21 | 2018-05-29 | Microcube, Llc | Methods and devices for delivering microwave energy |
US8808281B2 (en) * | 2008-10-21 | 2014-08-19 | Microcube, Llc | Microwave treatment devices and methods |
US8968287B2 (en) | 2008-10-21 | 2015-03-03 | Microcube, Llc | Methods and devices for applying energy to bodily tissues |
US10470819B2 (en) | 2008-11-10 | 2019-11-12 | Microcube, Llc | Methods and devices for applying energy to bodily tissues |
US9993293B2 (en) | 2008-11-10 | 2018-06-12 | Microcube, Llc | Methods and devices for applying energy to bodily tissues |
US11147619B2 (en) | 2008-11-10 | 2021-10-19 | Microcube, Llc | Methods and devices for applying energy to bodily tissues |
US20100121319A1 (en) * | 2008-11-10 | 2010-05-13 | Microcube, Llc | Methods and devices for applying energy to bodily tissues |
US9327100B2 (en) | 2008-11-14 | 2016-05-03 | Vessix Vascular, Inc. | Selective drug delivery in a lumen |
US8652129B2 (en) | 2008-12-31 | 2014-02-18 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
US20110060324A1 (en) * | 2008-12-31 | 2011-03-10 | Ardian, Inc. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
US10537385B2 (en) | 2008-12-31 | 2020-01-21 | Medtronic Ardian Luxembourg S.A.R.L. | Intravascular, thermally-induced renal neuromodulation for treatment of polycystic ovary syndrome or infertility |
CN102438690A (en) * | 2008-12-31 | 2012-05-02 | 美敦力阿迪安有限公司 | Apparatus, systems and methods for achieving intravascular, thermally-induced renal neuromodulation |
US8777942B2 (en) | 2008-12-31 | 2014-07-15 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
US10561460B2 (en) | 2008-12-31 | 2020-02-18 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation systems and methods for treatment of sexual dysfunction |
US20100168739A1 (en) * | 2008-12-31 | 2010-07-01 | Ardian, Inc. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
US20100168731A1 (en) * | 2008-12-31 | 2010-07-01 | Ardian, Inc. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
WO2010078175A1 (en) * | 2008-12-31 | 2010-07-08 | Ardian, Inc. | Apparatus, systems and methods for achieving intravascular, thermally-induced renal neuromodulation |
AU2009333040B2 (en) * | 2008-12-31 | 2014-08-21 | Medtronic Af Luxembourg S.A.R.L. | Apparatus, systems and methods for achieving intravascular, thermally-induced renal neuromodulation |
US8974445B2 (en) | 2009-01-09 | 2015-03-10 | Recor Medical, Inc. | Methods and apparatus for treatment of cardiac valve insufficiency |
EP2419040A2 (en) * | 2009-04-15 | 2012-02-22 | Medwaves, Inc. | Radio frequency based ablation system and method with dielectric transformer |
WO2010121047A2 (en) | 2009-04-15 | 2010-10-21 | Medwaves, Inc. | Radio frequency based ablation system and method with dielectric transformer |
EP2419040A4 (en) * | 2009-04-15 | 2013-01-23 | Medwaves Inc | Radio frequency based ablation system and method with dielectric transformer |
US8934989B2 (en) | 2009-04-15 | 2015-01-13 | Medwaves, Inc. | Radio frequency based ablation system and method with dielectric transformer |
US20100268219A1 (en) * | 2009-04-15 | 2010-10-21 | Medwaves, Inc. | Radio frequency based ablation system and method with dielectric transformer |
US9277961B2 (en) | 2009-06-12 | 2016-03-08 | Advanced Cardiac Therapeutics, Inc. | Systems and methods of radiometrically determining a hot-spot temperature of tissue being treated |
US9566115B2 (en) | 2009-07-28 | 2017-02-14 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US9877783B2 (en) | 2009-07-28 | 2018-01-30 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US10357312B2 (en) | 2009-07-28 | 2019-07-23 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US11013557B2 (en) | 2009-07-28 | 2021-05-25 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US9039698B2 (en) * | 2009-11-30 | 2015-05-26 | Medwaves, Inc. | Radio frequency ablation system with tracking sensor |
US20110130750A1 (en) * | 2009-11-30 | 2011-06-02 | Medwaves, Inc. | Radio frequency ablation system with tracking sensor |
US9277955B2 (en) | 2010-04-09 | 2016-03-08 | Vessix Vascular, Inc. | Power generating and control apparatus for the treatment of tissue |
US9192790B2 (en) | 2010-04-14 | 2015-11-24 | Boston Scientific Scimed, Inc. | Focused ultrasonic renal denervation |
US8728075B2 (en) | 2010-04-26 | 2014-05-20 | Medtronic Ardian Luxembourg S.A.R.L. | Multi-directional deflectable catheter apparatuses, systems, and methods for renal neuromodulation |
US8870863B2 (en) | 2010-04-26 | 2014-10-28 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses, systems, and methods for renal neuromodulation |
US9861440B2 (en) | 2010-05-03 | 2018-01-09 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US11490960B2 (en) | 2010-05-03 | 2022-11-08 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US10603106B2 (en) | 2010-05-03 | 2020-03-31 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US10524862B2 (en) | 2010-05-03 | 2020-01-07 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US9872729B2 (en) | 2010-05-03 | 2018-01-23 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US10799263B2 (en) * | 2010-05-07 | 2020-10-13 | Carefusion 2200, Inc. | Catheter design for use in treating pleural diseases |
US20130204279A1 (en) * | 2010-05-07 | 2013-08-08 | Carefusion 2200, Inc. | Catheter design for use in treating pleural diseases |
US8880185B2 (en) | 2010-06-11 | 2014-11-04 | Boston Scientific Scimed, Inc. | Renal denervation and stimulation employing wireless vascular energy transfer arrangement |
US9408661B2 (en) | 2010-07-30 | 2016-08-09 | Patrick A. Haverkost | RF electrodes on multiple flexible wires for renal nerve ablation |
US9155589B2 (en) | 2010-07-30 | 2015-10-13 | Boston Scientific Scimed, Inc. | Sequential activation RF electrode set for renal nerve ablation |
US9084609B2 (en) | 2010-07-30 | 2015-07-21 | Boston Scientific Scime, Inc. | Spiral balloon catheter for renal nerve ablation |
US9358365B2 (en) | 2010-07-30 | 2016-06-07 | Boston Scientific Scimed, Inc. | Precision electrode movement control for renal nerve ablation |
US9463062B2 (en) | 2010-07-30 | 2016-10-11 | Boston Scientific Scimed, Inc. | Cooled conductive balloon RF catheter for renal nerve ablation |
US10179020B2 (en) | 2010-10-25 | 2019-01-15 | Medtronic Ardian Luxembourg S.A.R.L. | Devices, systems and methods for evaluation and feedback of neuromodulation treatment |
US8974451B2 (en) | 2010-10-25 | 2015-03-10 | Boston Scientific Scimed, Inc. | Renal nerve ablation using conductive fluid jet and RF energy |
US9220558B2 (en) | 2010-10-27 | 2015-12-29 | Boston Scientific Scimed, Inc. | RF renal denervation catheter with multiple independent electrodes |
US9028485B2 (en) | 2010-11-15 | 2015-05-12 | Boston Scientific Scimed, Inc. | Self-expanding cooling electrode for renal nerve ablation |
US9848946B2 (en) | 2010-11-15 | 2017-12-26 | Boston Scientific Scimed, Inc. | Self-expanding cooling electrode for renal nerve ablation |
US9668811B2 (en) | 2010-11-16 | 2017-06-06 | Boston Scientific Scimed, Inc. | Minimally invasive access for renal nerve ablation |
US9089350B2 (en) | 2010-11-16 | 2015-07-28 | Boston Scientific Scimed, Inc. | Renal denervation catheter with RF electrode and integral contrast dye injection arrangement |
US9326751B2 (en) | 2010-11-17 | 2016-05-03 | Boston Scientific Scimed, Inc. | Catheter guidance of external energy for renal denervation |
US9060761B2 (en) | 2010-11-18 | 2015-06-23 | Boston Scientific Scime, Inc. | Catheter-focused magnetic field induced renal nerve ablation |
US9023034B2 (en) | 2010-11-22 | 2015-05-05 | Boston Scientific Scimed, Inc. | Renal ablation electrode with force-activatable conduction apparatus |
US9192435B2 (en) | 2010-11-22 | 2015-11-24 | Boston Scientific Scimed, Inc. | Renal denervation catheter with cooled RF electrode |
US9649156B2 (en) | 2010-12-15 | 2017-05-16 | Boston Scientific Scimed, Inc. | Bipolar off-wall electrode device for renal nerve ablation |
US20140012077A1 (en) * | 2011-01-11 | 2014-01-09 | Quanta System S.P.A. | Laser surgery device |
US9220561B2 (en) | 2011-01-19 | 2015-12-29 | Boston Scientific Scimed, Inc. | Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury |
US9579030B2 (en) | 2011-07-20 | 2017-02-28 | Boston Scientific Scimed, Inc. | Percutaneous devices and methods to visualize, target and ablate nerves |
US9186209B2 (en) | 2011-07-22 | 2015-11-17 | Boston Scientific Scimed, Inc. | Nerve modulation system having helical guide |
US9186210B2 (en) | 2011-10-10 | 2015-11-17 | Boston Scientific Scimed, Inc. | Medical devices including ablation electrodes |
US9420955B2 (en) | 2011-10-11 | 2016-08-23 | Boston Scientific Scimed, Inc. | Intravascular temperature monitoring system and method |
US10085799B2 (en) | 2011-10-11 | 2018-10-02 | Boston Scientific Scimed, Inc. | Off-wall electrode device and methods for nerve modulation |
US9364284B2 (en) | 2011-10-12 | 2016-06-14 | Boston Scientific Scimed, Inc. | Method of making an off-wall spacer cage |
US9162046B2 (en) | 2011-10-18 | 2015-10-20 | Boston Scientific Scimed, Inc. | Deflectable medical devices |
US9079000B2 (en) | 2011-10-18 | 2015-07-14 | Boston Scientific Scimed, Inc. | Integrated crossing balloon catheter |
US8951251B2 (en) | 2011-11-08 | 2015-02-10 | Boston Scientific Scimed, Inc. | Ostial renal nerve ablation |
US9119600B2 (en) | 2011-11-15 | 2015-09-01 | Boston Scientific Scimed, Inc. | Device and methods for renal nerve modulation monitoring |
US9119632B2 (en) | 2011-11-21 | 2015-09-01 | Boston Scientific Scimed, Inc. | Deflectable renal nerve ablation catheter |
US11638607B2 (en) | 2011-12-21 | 2023-05-02 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US9265969B2 (en) | 2011-12-21 | 2016-02-23 | Cardiac Pacemakers, Inc. | Methods for modulating cell function |
US10667860B2 (en) | 2011-12-21 | 2020-06-02 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US9072902B2 (en) | 2011-12-23 | 2015-07-07 | Vessix Vascular, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
US9592386B2 (en) | 2011-12-23 | 2017-03-14 | Vessix Vascular, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
US9402684B2 (en) | 2011-12-23 | 2016-08-02 | Boston Scientific Scimed, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
US9174050B2 (en) | 2011-12-23 | 2015-11-03 | Vessix Vascular, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
US9037259B2 (en) | 2011-12-23 | 2015-05-19 | Vessix Vascular, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
US9028472B2 (en) | 2011-12-23 | 2015-05-12 | Vessix Vascular, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
US9186211B2 (en) | 2011-12-23 | 2015-11-17 | Boston Scientific Scimed, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
US9433760B2 (en) | 2011-12-28 | 2016-09-06 | Boston Scientific Scimed, Inc. | Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements |
US10905494B2 (en) | 2011-12-29 | 2021-02-02 | St. Jude Medical, Atrial Fibrillation Division, Inc | Flexible conductive polymer based conformable device and method to create linear endocardial lesions |
US9050106B2 (en) | 2011-12-29 | 2015-06-09 | Boston Scientific Scimed, Inc. | Off-wall electrode device and methods for nerve modulation |
US8926605B2 (en) | 2012-02-07 | 2015-01-06 | Advanced Cardiac Therapeutics, Inc. | Systems and methods for radiometrically measuring temperature during tissue ablation |
WO2013119620A1 (en) * | 2012-02-07 | 2013-08-15 | Advanced Cardiac Therapeutics, Inc. | Systems and methods for radiometrically measuring temperature during tissue ablation |
US8932284B2 (en) | 2012-02-07 | 2015-01-13 | Advanced Cardiac Therapeutics, Inc. | Methods of determining tissue temperatures in energy delivery procedures |
US10874455B2 (en) | 2012-03-08 | 2020-12-29 | Medtronic Ardian Luxembourg S.A.R.L. | Ovarian neuromodulation and associated systems and methods |
US11338140B2 (en) | 2012-03-08 | 2022-05-24 | Medtronic Ardian Luxembourg S.A.R.L. | Monitoring of neuromodulation using biomarkers |
US8961506B2 (en) | 2012-03-12 | 2015-02-24 | Advanced Cardiac Therapeutics, Inc. | Methods of automatically regulating operation of ablation members based on determined temperatures |
US9226791B2 (en) | 2012-03-12 | 2016-01-05 | Advanced Cardiac Therapeutics, Inc. | Systems for temperature-controlled ablation using radiometric feedback |
US10660703B2 (en) | 2012-05-08 | 2020-05-26 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices |
US8954161B2 (en) | 2012-06-01 | 2015-02-10 | Advanced Cardiac Therapeutics, Inc. | Systems and methods for radiometrically measuring temperature and detecting tissue contact prior to and during tissue ablation |
US9014814B2 (en) | 2012-06-01 | 2015-04-21 | Advanced Cardiac Therapeutics, Inc. | Methods of determining tissue contact based on radiometric signals |
US11426573B2 (en) | 2012-08-09 | 2022-08-30 | University Of Iowa Research Foundation | Catheters, catheter systems, and methods for puncturing through a tissue structure and ablating a tissue region |
US10321946B2 (en) | 2012-08-24 | 2019-06-18 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices with weeping RF ablation balloons |
US9173696B2 (en) | 2012-09-17 | 2015-11-03 | Boston Scientific Scimed, Inc. | Self-positioning electrode system and method for renal nerve modulation |
US10398464B2 (en) | 2012-09-21 | 2019-09-03 | Boston Scientific Scimed, Inc. | System for nerve modulation and innocuous thermal gradient nerve block |
US10549127B2 (en) | 2012-09-21 | 2020-02-04 | Boston Scientific Scimed, Inc. | Self-cooling ultrasound ablation catheter |
US10835305B2 (en) | 2012-10-10 | 2020-11-17 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices and methods |
US10080864B2 (en) | 2012-10-19 | 2018-09-25 | Medtronic Ardian Luxembourg S.A.R.L. | Packaging for catheter treatment devices and associated devices, systems, and methods |
US9956033B2 (en) | 2013-03-11 | 2018-05-01 | Boston Scientific Scimed, Inc. | Medical devices for modulating nerves |
US9693821B2 (en) | 2013-03-11 | 2017-07-04 | Boston Scientific Scimed, Inc. | Medical devices for modulating nerves |
US9808311B2 (en) | 2013-03-13 | 2017-11-07 | Boston Scientific Scimed, Inc. | Deflectable medical devices |
US9827039B2 (en) | 2013-03-15 | 2017-11-28 | Boston Scientific Scimed, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
US10265122B2 (en) | 2013-03-15 | 2019-04-23 | Boston Scientific Scimed, Inc. | Nerve ablation devices and related methods of use |
US9297845B2 (en) | 2013-03-15 | 2016-03-29 | Boston Scientific Scimed, Inc. | Medical devices and methods for treatment of hypertension that utilize impedance compensation |
US10022182B2 (en) | 2013-06-21 | 2018-07-17 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation having rotatable shafts |
US9943365B2 (en) | 2013-06-21 | 2018-04-17 | Boston Scientific Scimed, Inc. | Renal denervation balloon catheter with ride along electrode support |
US9707036B2 (en) | 2013-06-25 | 2017-07-18 | Boston Scientific Scimed, Inc. | Devices and methods for nerve modulation using localized indifferent electrodes |
US9833283B2 (en) | 2013-07-01 | 2017-12-05 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation |
US10413357B2 (en) | 2013-07-11 | 2019-09-17 | Boston Scientific Scimed, Inc. | Medical device with stretchable electrode assemblies |
US10660698B2 (en) | 2013-07-11 | 2020-05-26 | Boston Scientific Scimed, Inc. | Devices and methods for nerve modulation |
US9925001B2 (en) | 2013-07-19 | 2018-03-27 | Boston Scientific Scimed, Inc. | Spiral bipolar electrode renal denervation balloon |
US10342609B2 (en) | 2013-07-22 | 2019-07-09 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation |
US10695124B2 (en) | 2013-07-22 | 2020-06-30 | Boston Scientific Scimed, Inc. | Renal nerve ablation catheter having twist balloon |
US10722300B2 (en) | 2013-08-22 | 2020-07-28 | Boston Scientific Scimed, Inc. | Flexible circuit having improved adhesion to a renal nerve modulation balloon |
US9895194B2 (en) | 2013-09-04 | 2018-02-20 | Boston Scientific Scimed, Inc. | Radio frequency (RF) balloon catheter having flushing and cooling capability |
US10952790B2 (en) | 2013-09-13 | 2021-03-23 | Boston Scientific Scimed, Inc. | Ablation balloon with vapor deposited cover layer |
WO2015042173A1 (en) * | 2013-09-20 | 2015-03-26 | Advanced Cardiac Therapeutics, Inc. | Temperature sensing and tissue ablation using a plurality of electrodes |
US9687166B2 (en) | 2013-10-14 | 2017-06-27 | Boston Scientific Scimed, Inc. | High resolution cardiac mapping electrode array catheter |
US11246654B2 (en) | 2013-10-14 | 2022-02-15 | Boston Scientific Scimed, Inc. | Flexible renal nerve ablation devices and related methods of use and manufacture |
US9962223B2 (en) | 2013-10-15 | 2018-05-08 | Boston Scientific Scimed, Inc. | Medical device balloon |
US9770606B2 (en) | 2013-10-15 | 2017-09-26 | Boston Scientific Scimed, Inc. | Ultrasound ablation catheter with cooling infusion and centering basket |
US10945786B2 (en) | 2013-10-18 | 2021-03-16 | Boston Scientific Scimed, Inc. | Balloon catheters with flexible conducting wires and related methods of use and manufacture |
US10271898B2 (en) | 2013-10-25 | 2019-04-30 | Boston Scientific Scimed, Inc. | Embedded thermocouple in denervation flex circuit |
US10517672B2 (en) * | 2014-01-06 | 2019-12-31 | Farapulse, Inc. | Apparatus and methods for renal denervation ablation |
US20160310211A1 (en) * | 2014-01-06 | 2016-10-27 | Iowa Approach Inc. | Apparatus and methods for renal denervation ablation |
US11202671B2 (en) | 2014-01-06 | 2021-12-21 | Boston Scientific Scimed, Inc. | Tear resistant flex circuit assembly |
US11589919B2 (en) | 2014-01-06 | 2023-02-28 | Boston Scientific Scimed, Inc. | Apparatus and methods for renal denervation ablation |
US9907609B2 (en) | 2014-02-04 | 2018-03-06 | Boston Scientific Scimed, Inc. | Alternative placement of thermal sensors on bipolar electrode |
US11000679B2 (en) | 2014-02-04 | 2021-05-11 | Boston Scientific Scimed, Inc. | Balloon protection and rewrapping devices and related methods of use |
US10194979B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
US10194980B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
US9980766B1 (en) | 2014-03-28 | 2018-05-29 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and systems for renal neuromodulation |
US11259869B2 (en) | 2014-05-07 | 2022-03-01 | Farapulse, Inc. | Methods and apparatus for selective tissue ablation |
US10624693B2 (en) | 2014-06-12 | 2020-04-21 | Farapulse, Inc. | Method and apparatus for rapid and selective tissue ablation with cooling |
US11241282B2 (en) | 2014-06-12 | 2022-02-08 | Boston Scientific Scimed, Inc. | Method and apparatus for rapid and selective transurethral tissue ablation |
US11622803B2 (en) | 2014-06-12 | 2023-04-11 | Boston Scientific Scimed, Inc. | Method and apparatus for rapid and selective tissue ablation with cooling |
US10433906B2 (en) | 2014-06-12 | 2019-10-08 | Farapulse, Inc. | Method and apparatus for rapid and selective transurethral tissue ablation |
US10835314B2 (en) | 2014-10-14 | 2020-11-17 | Farapulse, Inc. | Method and apparatus for rapid and safe pulmonary vein cardiac ablation |
US9999465B2 (en) | 2014-10-14 | 2018-06-19 | Iowa Approach, Inc. | Method and apparatus for rapid and safe pulmonary vein cardiac ablation |
US10231779B2 (en) | 2014-11-19 | 2019-03-19 | Epix Therapeutics, Inc. | Ablation catheter with high-resolution electrode assembly |
US9517103B2 (en) | 2014-11-19 | 2016-12-13 | Advanced Cardiac Therapeutics, Inc. | Medical instruments with multiple temperature sensors |
US11534227B2 (en) | 2014-11-19 | 2022-12-27 | Epix Therapeutics, Inc. | High-resolution mapping of tissue with pacing |
US9522037B2 (en) | 2014-11-19 | 2016-12-20 | Advanced Cardiac Therapeutics, Inc. | Treatment adjustment based on temperatures from multiple temperature sensors |
US10166062B2 (en) | 2014-11-19 | 2019-01-01 | Epix Therapeutics, Inc. | High-resolution mapping of tissue with pacing |
US10499983B2 (en) | 2014-11-19 | 2019-12-10 | Epix Therapeutics, Inc. | Ablation systems and methods using heat shunt networks |
US10660701B2 (en) | 2014-11-19 | 2020-05-26 | Epix Therapeutics, Inc. | Methods of removing heat from an electrode using thermal shunting |
US11701171B2 (en) | 2014-11-19 | 2023-07-18 | Epix Therapeutics, Inc. | Methods of removing heat from an electrode using thermal shunting |
US9522036B2 (en) | 2014-11-19 | 2016-12-20 | Advanced Cardiac Therapeutics, Inc. | Ablation devices, systems and methods of using a high-resolution electrode assembly |
US10413212B2 (en) | 2014-11-19 | 2019-09-17 | Epix Therapeutics, Inc. | Methods and systems for enhanced mapping of tissue |
US11642167B2 (en) | 2014-11-19 | 2023-05-09 | Epix Therapeutics, Inc. | Electrode assembly with thermal shunt member |
US11135009B2 (en) | 2014-11-19 | 2021-10-05 | Epix Therapeutics, Inc. | Electrode assembly with thermal shunt member |
US10383686B2 (en) | 2014-11-19 | 2019-08-20 | Epix Therapeutics, Inc. | Ablation systems with multiple temperature sensors |
US9510905B2 (en) | 2014-11-19 | 2016-12-06 | Advanced Cardiac Therapeutics, Inc. | Systems and methods for high-resolution mapping of tissue |
US9592092B2 (en) | 2014-11-19 | 2017-03-14 | Advanced Cardiac Therapeutics, Inc. | Orientation determination based on temperature measurements |
US9636164B2 (en) | 2015-03-25 | 2017-05-02 | Advanced Cardiac Therapeutics, Inc. | Contact sensing systems and methods |
US10675081B2 (en) | 2015-03-25 | 2020-06-09 | Epix Therapeutics, Inc. | Contact sensing systems and methods |
US11576714B2 (en) | 2015-03-25 | 2023-02-14 | Epix Therapeutics, Inc. | Contact sensing systems and methods |
US10952792B2 (en) | 2015-10-26 | 2021-03-23 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US11678935B2 (en) | 2015-10-26 | 2023-06-20 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
US11589921B2 (en) | 2016-01-05 | 2023-02-28 | Boston Scientific Scimed, Inc. | Systems, apparatuses and methods for delivery of ablative energy to tissue |
US10512779B2 (en) | 2016-01-05 | 2019-12-24 | Farapulse, Inc. | Systems, apparatuses and methods for delivery of ablative energy to tissue |
US11020179B2 (en) | 2016-01-05 | 2021-06-01 | Farapulse, Inc. | Systems, devices, and methods for focal ablation |
US10322286B2 (en) | 2016-01-05 | 2019-06-18 | Farapulse, Inc. | Systems, apparatuses and methods for delivery of ablative energy to tissue |
US10842561B2 (en) | 2016-01-05 | 2020-11-24 | Farapulse, Inc. | Systems, devices, and methods for delivery of pulsed electric field ablative energy to endocardial tissue |
US10433908B2 (en) | 2016-01-05 | 2019-10-08 | Farapulse, Inc. | Systems, devices, and methods for delivery of pulsed electric field ablative energy to endocardial tissue |
US10660702B2 (en) | 2016-01-05 | 2020-05-26 | Farapulse, Inc. | Systems, devices, and methods for focal ablation |
US10709891B2 (en) | 2016-01-05 | 2020-07-14 | Farapulse, Inc. | Systems, apparatuses and methods for delivery of ablative energy to tissue |
US10172673B2 (en) | 2016-01-05 | 2019-01-08 | Farapulse, Inc. | Systems devices, and methods for delivery of pulsed electric field ablative energy to endocardial tissue |
US9993178B2 (en) | 2016-03-15 | 2018-06-12 | Epix Therapeutics, Inc. | Methods of determining catheter orientation |
US11389230B2 (en) | 2016-03-15 | 2022-07-19 | Epix Therapeutics, Inc. | Systems for determining catheter orientation |
US11179197B2 (en) | 2016-03-15 | 2021-11-23 | Epix Therapeutics, Inc. | Methods of determining catheter orientation |
US10531917B2 (en) | 2016-04-15 | 2020-01-14 | Neuwave Medical, Inc. | Systems and methods for energy delivery |
US11395699B2 (en) | 2016-04-15 | 2022-07-26 | Neuwave Medical, Inc. | Systems and methods for energy delivery |
US10507302B2 (en) | 2016-06-16 | 2019-12-17 | Farapulse, Inc. | Systems, apparatuses, and methods for guide wire delivery |
US11090114B2 (en) * | 2016-07-11 | 2021-08-17 | Gyrus Medical Limited | System and method for monitoring tissue temperature |
US20180008345A1 (en) * | 2016-07-11 | 2018-01-11 | Gyrus Medical Limited | System and method for monitoring a microwave tissue ablation process |
US20180008346A1 (en) * | 2016-07-11 | 2018-01-11 | Gyrus Medical Limited | System and method for monitoring tissue temperature |
US11076915B2 (en) * | 2016-07-11 | 2021-08-03 | Gyrus Medical Limited | System and method for monitoring a microwave tissue ablation process |
US20210106381A1 (en) * | 2017-04-03 | 2021-04-15 | Broncus Medical Inc. | Electrosurgical access sheath |
WO2018187244A3 (en) * | 2017-04-03 | 2019-03-07 | Broncus Medical Inc. | Electrosurgical access sheath |
US11832877B2 (en) * | 2017-04-03 | 2023-12-05 | Broncus Medical Inc. | Electrosurgical access sheath |
US10888373B2 (en) | 2017-04-27 | 2021-01-12 | Epix Therapeutics, Inc. | Contact assessment between an ablation catheter and tissue |
US11357978B2 (en) | 2017-04-27 | 2022-06-14 | Boston Scientific Scimed, Inc. | Systems, devices, and methods for signal generation |
US10016232B1 (en) | 2017-04-27 | 2018-07-10 | Iowa Approach, Inc. | Systems, devices, and methods for signal generation |
US10893903B2 (en) | 2017-04-27 | 2021-01-19 | Epix Therapeutics, Inc. | Medical instruments having contact assessment features |
US9987081B1 (en) | 2017-04-27 | 2018-06-05 | Iowa Approach, Inc. | Systems, devices, and methods for signal generation |
US11617618B2 (en) | 2017-04-27 | 2023-04-04 | Epix Therapeutics, Inc. | Contact assessment between an ablation catheter and tissue |
US10617867B2 (en) | 2017-04-28 | 2020-04-14 | Farapulse, Inc. | Systems, devices, and methods for delivery of pulsed electric field ablative energy to esophageal tissue |
US11833350B2 (en) | 2017-04-28 | 2023-12-05 | Boston Scientific Scimed, Inc. | Systems, devices, and methods for delivery of pulsed electric field ablative energy to esophageal tissue |
US10130423B1 (en) | 2017-07-06 | 2018-11-20 | Farapulse, Inc. | Systems, devices, and methods for focal ablation |
US10617467B2 (en) | 2017-07-06 | 2020-04-14 | Farapulse, Inc. | Systems, devices, and methods for focal ablation |
US10893905B2 (en) | 2017-09-12 | 2021-01-19 | Farapulse, Inc. | Systems, apparatuses, and methods for ventricular focal ablation |
US11672596B2 (en) | 2018-02-26 | 2023-06-13 | Neuwave Medical, Inc. | Energy delivery devices with flexible and adjustable tips |
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Also Published As
Publication number | Publication date |
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WO2008051708A3 (en) | 2008-06-19 |
US8308722B2 (en) | 2012-11-13 |
ES2546754T3 (en) | 2015-09-28 |
CN101534737B (en) | 2011-07-06 |
WO2008051708A2 (en) | 2008-05-02 |
EP2073738A4 (en) | 2011-06-15 |
CN101534737A (en) | 2009-09-16 |
US20080015570A1 (en) | 2008-01-17 |
EP2073738A2 (en) | 2009-07-01 |
EP2073738B1 (en) | 2015-06-10 |
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