JP2004525889A5 - - Google Patents

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JP2004525889A5
JP2004525889A5 JP2002559408A JP2002559408A JP2004525889A5 JP 2004525889 A5 JP2004525889 A5 JP 2004525889A5 JP 2002559408 A JP2002559408 A JP 2002559408A JP 2002559408 A JP2002559408 A JP 2002559408A JP 2004525889 A5 JP2004525889 A5 JP 2004525889A5
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alkyl
dioxo
dioxoisoindoline
piperidyl
methyl
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Claims (13)

  1. 以下の式を有する化合物。
    Figure 2004525889
     ［式中、
    R1はH、(C1-C8)アルキル、(C3-C7)シクロアルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、(C0-C4)アルキル-(C1-C6)ヘテロシクロアルキル、(C0-C4)アルキル-(C2-C5)ヘテロアリール、C(O)R3、C(S)R3、C(O)OR4、(C1-C8)アルキル-N(R6)2、(C1-C8)アルキル-OR5、(C1-C8)アルキル-C(O)OR5、C(O)NHR3、C(S)NHR3、C(O)NR3R3'、C(S)NR3R3'または(C1-C8)アルキル-O(CO)R5であり、
    R2はHまたは(C1-C8)アルキルであり、
    R3及びR3'は独立して(C1-C8)アルキル、(C3-C7)シクロアルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、(C0-C4)アルキル-(C1-C6)ヘテロシクロアルキル、(C0-C4)アルキル-(C2-C5)ヘテロアリール、(C0-C8)アルキル-N(R6)2、(C1-C8)アルキル-OR5、(C1-C8)アルキル-C(O)OR5、(C1-C8)アルキル-O(CO)R5、またはC(O)OR5であり、
    R4は(C1-C8)アルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、(C1-C4)アルキル-OR5、ベンジル、アリール、(C0-C4)アルキル-(C1-C6)ヘテロシクロアルキル、または(C0-C4)アルキル-(C2-C5)ヘテロアリールであり、
    R5は(C1-C8)アルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、または(C2-C5)ヘテロアリールであり、
    R6はそれぞれ独立してH、(C1-C8)アルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、(C2-C5)ヘテロアリール、または(C0-C8)アルキル-C(O)O-R5であるか、R6基が結合してヘテロシクロアルキル基を形成し、そして
    ＊はキラル炭素中心を示す。］
  2. R1がH、(C1-C4)アルキル、CH2OCH3、CH2CH2OCH3、または
    Figure 2004525889
     であり、QがOまたはSであり、そしてR7はそれぞれ独立してH、(C1-C8)アルキル、(C3-C7)シクロアルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、ハロゲン、(C0-C4)アルキル-(C1-C6)ヘテロシクロアルキル、(C0-C4)アルキル-(C2-C5)ヘテロアリール、(C0-C8)アルキル-N(R6)2、(C1-C8)アルキル-OR5、(C1-C8)アルキル-C(O)OR5、(C1-C8)アルキル-O(CO)R5、またはC(O)OR5であるか、あるいは隣り合ったR7が一緒になって二環式アルキル環またはアリール環を形成する、請求項１記載の化合物。
  3. R1がC(O)R3である、請求項１記載の化合物。
  4. R1がC(O)OR4である、請求項１記載の化合物。
  5. 以下の式を有する化合物。
    Figure 2004525889
     ［式中、
    R1はH、(C1-C8)アルキル、(C3-C7)シクロアルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、(C0-C4)アルキル-(C1-C6)ヘテロシクロアルキル、(C0-C4)アルキル-(C2-C5)ヘテロアリール、C(O)R3、C(S)R3、C(O)OR4、(C1-C8)アルキル-N(R6)2、(C1-C8)アルキル-OR5、(C1-C8)アルキル-C(O)OR5、C(O)NHR3、C(S)NHR3、C(O)NR3R3'、C(S)NR3R3'または(C1-C8)アルキル-O(CO)R5であり、
    R2はHまたは(C1-C8)アルキルであり、
    R3及びR3'は独立して(C1-C8)アルキル、(C3-C7)シクロアルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、(C0-C4)アルキル-(C1-C6)ヘテロシクロアルキル、(C0-C4)アルキル-(C2-C5)ヘテロアリール、(C0-C8)アルキル-N(R6)2、(C1-C8)アルキル-OR5、(C1-C8)アルキル-C(O)OR5、(C1-C8)アルキル-O(CO)R5、またはC(O)OR5であり、
    R4は(C1-C8)アルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、(C1-C4)アルキル-OR5、ベンジル、アリール、(C0-C4)アルキル-(C1-C6)ヘテロシクロアルキル、または(C0-C4)アルキル-(C2-C5)ヘテロアリールであり、
    R5は(C1-C8)アルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、または(C2-C5)ヘテロアリールであり、
    R6はそれぞれ独立してH、(C1-C8)アルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、(C2-C5)ヘテロアリール、または(C0-C8)アルキル-C(O)O-R5であるか、R6基が結合してヘテロシクロアルキル基を形成し、そして
    ＊はキラル炭素中心を示す。］
  6. R1がH、(C1-C4)アルキル、CH2OCH3、CH2CH2OCH3、または
    Figure 2004525889
     であり、QがOまたはSであり、そしてR7はそれぞれ独立してH、(C1-C8)アルキル、(C3-C7)シクロアルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、ハロゲン、(C0-C4)アルキル-(C1-C6)ヘテロシクロアルキル、(C0-C4)アルキル-(C2-C5)ヘテロアリール、(C0-C8)アルキル-N(R6)2、(C1-C8)アルキル-OR5、(C1-C8)アルキル-C(O)OR5、(C1-C8)アルキル-O(CO)R5、またはC(O)OR5であるか、あるいは隣り合ったR7が一緒になって二環式アルキル環またはアリール環を形成する、請求項５記載の化合物。
  7. R1がC(O)R3である、請求項５記載の化合物。
  8. R1がC(O)OR4である、請求項５記載の化合物。
  9. 以下の式を有する化合物。
    Figure 2004525889
     ［式中、
    R1はH、(C1-C8)アルキル、(C3-C7)シクロアルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、(C0-C4)アルキル-(C1-C6)ヘテロシクロアルキル、(C0-C4)アルキル-(C2-C5)ヘテロアリール、C(O)R3、C(S)R3、C(O)OR4、(C1-C8)アルキル-N(R6)2、(C1-C8)アルキル-OR5、(C1-C8)アルキル-C(O)OR5、C(O)NHR3、C(S)NHR3、C(O)NR3R3'、C(S)NR3R3'または(C1-C8)アルキル-O(CO)R5であり、
    R2はHまたは(C1-C8)アルキルであり、
    R3及びR3'は独立して(C1-C8)アルキル、(C3-C7)シクロアルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、(C0-C4)アルキル-(C1-C6)ヘテロシクロアルキル、(C0-C4)アルキル-(C2-C5)ヘテロアリール、(C0-C8)アルキル-N(R6)2、(C1-C8)アルキル-OR5、(C1-C8)アルキル-C(O)OR5、(C1-C8)アルキル-O(CO)R5、またはC(O)OR5であり、
    R4は(C1-C8)アルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、(C1-C4)アルキル-OR5、ベンジル、アリール、(C0-C4)アルキル-(C1-C6)ヘテロシクロアルキル、または(C0-C4)アルキル-(C2-C5)ヘテロアリールであり、
    R5は(C1-C8)アルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、または(C2-C5)ヘテロアリールであり、
    R6はそれぞれ独立してH、(C1-C8)アルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、(C2-C5)ヘテロアリール、または(C0-C8)アルキル-C(O)O-R5であるか、R6基が結合してヘテロシクロアルキル基を形成し、そして
    ＊はキラル炭素中心を示す。］
  10. R1がH、(C1-C4)アルキル、CH2OCH3、CH2CH2OCH3、または
    Figure 2004525889
     であり、QがOまたはSであり、そしてR7はそれぞれ独立してH、(C1-C8)アルキル、(C3-C7)シクロアルキル、(C2-C8)アルケニル、(C2-C8)アルキニル、ベンジル、アリール、ハロゲン、(C0-C4)アルキル-(C1-C6)ヘテロシクロアルキル、(C0-C4)アルキル-(C2-C5)ヘテロアリール、(C0-C8)アルキル-N(R6)2、(C1-C8)アルキル-OR5、(C1-C8)アルキル-C(O)OR5、(C1-C8)アルキル-O(CO)R5、またはC(O)OR5であるか、あるいは隣り合ったR7が一緒になって二環式アルキル環またはアリール環を形成する、請求項９記載の化合物。
  11. R1がC(O)R3である、請求項９記載の化合物。
  12. R1がC(O)OR4である、請求項９記載の化合物。
  13. N-[2-(2,6-ジオキソ-ピペリジン-3-イル)-1,3-ジオキソ-2,3-ジヒドロ-1H-イソインドール-4-イルメチル]-アセトアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}シクロプロピル-カルボキシアミド；
    1-tert-ブチル-3-[2-(2,6-ジオキソ-ピペリジン-3-イル)-1,3-ジオキソ-2,3-ジヒドロ-1H-イソインドール-4-イルメチル]-尿素；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}-3,3-ジメチルブタンアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}プロパンアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}-3-ピリジルカルボキシアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}ヘプタンアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}-2-フリルカルボキシアミド；
    2-アミノ-N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}アセトアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}-2-チエニルカルボキシアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}(エチルアミノ)カルボキシアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}ブタンアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}-2-ピリジルカルボキシアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}-2-メチルプロパンアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}シクロペンチルカルボキシアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}シクロヘキシルカルボキシアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}(ブチルアミノ)カルボキシアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}(プロピルアミノ)カルボキシアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}(シクロヘキシルアミノ)カルボキシアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}[(メチルエチルアミノ)]カルボキシアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}(オクチルアミノ)カルボキシアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}(シクロプロピルアミノ)カルボキシアミド；
    N-{[2-(2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチル}(ジエチルアミノ)カルボキシアミド；
    シクロプロピル-N-{2-(3-メチル-2,6-ジオキソ(3-ピペリジル))-1,3-ジオキソイソインドリン-4-イル]メチルカルボキシアミド；
    である請求項１記載の化合物。
JP2002559408A 2000-12-27 2001-12-21 イソインドール−イミド化合物、組成物、およびそれらの使用 Expired - Fee Related JP4284071B2 (ja)

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Application Number Priority Date Filing Date Title
US25837200P 2000-12-27 2000-12-27
US09/972,487 US20030045552A1 (en) 2000-12-27 2001-10-05 Isoindole-imide compounds, compositions, and uses thereof
PCT/US2001/050401 WO2002059106A1 (en) 2000-12-27 2001-12-21 Isoindole-imide compounds, compositions, and uses thereof

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JP2004525889A JP2004525889A (ja) 2004-08-26
JP2004525889A5 true JP2004525889A5 (ja) 2006-01-05
JP4284071B2 JP4284071B2 (ja) 2009-06-24

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JP2005321049A Expired - Fee Related JP4648822B2 (ja) 2000-12-27 2005-11-04 イソインドール−イミド化合物、組成物、およびそれらの使用
JP2010110388A Pending JP2010195824A (ja) 2000-12-27 2010-05-12 イソインドール−イミド化合物、組成物、およびそれらの使用

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US (1) US20030045552A1 (ja)
EP (3) EP2168958A1 (ja)
JP (3) JP4284071B2 (ja)
KR (4) KR100802713B1 (ja)
AT (1) ATE352548T1 (ja)
AU (3) AU2002248252B2 (ja)
CA (1) CA2433021C (ja)
CY (1) CY1106423T1 (ja)
CZ (1) CZ20032041A3 (ja)
DE (1) DE60126344T2 (ja)
DK (1) DK1363900T3 (ja)
ES (1) ES2275758T3 (ja)
HK (1) HK1061396A1 (ja)
HU (1) HU229003B1 (ja)
IL (2) IL156646A0 (ja)
MX (1) MXPA03005786A (ja)
NZ (1) NZ526893A (ja)
PT (1) PT1363900E (ja)
WO (1) WO2002059106A1 (ja)
ZA (1) ZA200305759B (ja)

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