JP2003523764A5 - - Google Patents
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- JP2003523764A5 JP2003523764A5 JP2001562582A JP2001562582A JP2003523764A5 JP 2003523764 A5 JP2003523764 A5 JP 2003523764A5 JP 2001562582 A JP2001562582 A JP 2001562582A JP 2001562582 A JP2001562582 A JP 2001562582A JP 2003523764 A5 JP2003523764 A5 JP 2003523764A5
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- 102000004965 antibodies Human genes 0.000 description 9
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- 108010064750 Humanized Monoclonal Antibodies Proteins 0.000 description 2
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Description
【特許請求の範囲】
【請求項１】 ａ．以下のアミノ酸配列を有する３つの軽鎖相補性決定領域（ＣＤＲｓ）：
軽鎖ＣＤＲ１：
【数１】
または
【数２】
軽鎖ＣＤＲ２：
【数３】
および、軽鎖ＣＤＲ３：
【数４】
およびヒト化免疫グロブリン軽鎖由来の軽鎖フレームワーク配列、
ならびに
ｂ．以下のアミノ酸配列を有する３つの重鎖ＣＤＲｓを含む重鎖：
重鎖ＣＤＲ１：
【数５】
重鎖ＣＤＲ２：
【数６】
または
【数７】
および、重鎖ＣＤＲ３：
【数８】
およびヒト化免疫グロブリン重鎖由来の重鎖フレームワーク配列、を含む
ヒト化抗体またはその断片。
【請求項２】 軽鎖ＣＤＲ１が
【数９】
であり、重鎖ＣＤＲ２が
【数１０】
である請求項１記載のヒト化抗体またはその断片。
【請求項３】 以下の配列を含むヒト化軽鎖可変領域：
【数１１】
［式中：
第２位のＸａａはＶａｌまたはＩｌｅであり；
第７位のＸａａはＳｅｒまたはＴｈｒであり；
第１４位のＸａａはＴｈｒまたはＳｅｒであり；
第１５位のＸａａはＬｅｕまたはＰｒｏであり；
第３０位のＸａａはＩｌｅまたはＶａｌであり；
第５０位のＸａａはＡｒｇ、Ｇｌｎ、またはＬｙｓであり；
第８８位のＸａａはＶａｌまたはＬｅｕであり；
第１０５位のＸａａはＧｌｎまたはＧｌｙであり；
第１０８位のＸａａはＬｙｓまたはＡｒｇであり；ならびに、
第１０９位のＸａａはＶａｌまたはＬｅｕである］
および以下の配列を含む重鎖可変領域：
【数１２】
［式中：
第１位のＸａａはＧｌｕまたはＧｌｎであり；
第７位のＸａａはＳｅｒまたはＬｅｕであり；
第４６位のＸａａはＧｌｕ、Ｖａｌ、Ａｓｐ、またはＳｅｒであり；
第６３位のＸａａはＴｈｒまたはＳｅｒであり；
第７５位のＸａａはＡｌａ、Ｓｅｒ、Ｖａｌ、またはＴｈｒであり；
第７６位のＸａａはＬｙｓまたはＡｒｇであり；
第８９位のＸａａはＧｌｕまたはＡｓｐであり；ならびに、
第１０７位のＸａａはＬｅｕまたはＴｈｒである］
を含む、請求項１ に記載のヒト化抗体またはその断片。
【請求項４】 配列番号９に記載の配列の軽鎖可変領域および配列番号１０に記載の重鎖可変領域を有する、請求項１ に記載のヒト化抗体またはその断片。
【請求項５】 配列番号１１に記載の配列の軽鎖および配列番号１２に記載の配列の重鎖を有する、請求項４に記載のヒト化抗体またはその断片。
【請求項６】 請求項１〜５のいずれかに記載のヒト化抗体の 抗体断片。
【請求項７】 適当な宿主細胞内で発現された場合に、請求項１〜６のいずれかに記載の抗体を産生する、１またはそれ以上のポリ核酸。
【請求項８】 請求項１〜６のいずれかに記載の抗体 を発現するための発現ベクターであって、該抗体または断片をコードするポリヌクレオチド配列を含む発現ベクター。
【請求項９】 請求項１〜６のいずれかに記載のヒト化抗体または断片を発現することができる細胞。
【請求項１０】 請求項１〜６のいずれかに記載のヒト化抗体または断片および製薬的に許容される賦形剤を含む医薬組成物。
【請求項１１】 ヒト被検体におけるアミロイドプラークの形成または毒性の可溶性Ａβ種の作用を阻害し、アミロイドプラークまたは毒性の可溶性Ａβ種の作用を減少させ、認識減退を逆転させ、認識減退を予防し、または認識を改善させる方法であって、 ヒト被検体に、請求項１〜６のいずれかに記載のヒト化抗体またはその断片の有効量を投与することを含む方法。
【請求項１２】 臨床的または前臨床的なアルツハイマー疾患、ダウン症候群、または臨床的または前臨床的な脳性アミロイド血管障害と診断されたヒト被検体における臨床的または前臨床的なアルツハイマー疾患、ダウン症候群、または臨床的または前臨床的な脳性アミロイド血管障害を治療する方法であって、該ヒト被検体に、請求項１〜６のいずれかに記載のヒト化抗体またはその断片の有効量を投与することを含む方法。
【請求項１】 ａ．以下のアミノ酸配列を有する３つの軽鎖相補性決定領域（ＣＤＲｓ）：
軽鎖ＣＤＲ１：
【数１】
【数２】
【数３】
【数４】
ならびに
ｂ．以下のアミノ酸配列を有する３つの重鎖ＣＤＲｓを含む重鎖：
重鎖ＣＤＲ１：
【数５】
【数６】
【数７】
【数８】
ヒト化抗体またはその断片。
【請求項２】 軽鎖ＣＤＲ１が
【数９】
【数１０】
【請求項３】 以下の配列を含むヒト化軽鎖可変領域：
【数１１】
第２位のＸａａはＶａｌまたはＩｌｅであり；
第７位のＸａａはＳｅｒまたはＴｈｒであり；
第１４位のＸａａはＴｈｒまたはＳｅｒであり；
第１５位のＸａａはＬｅｕまたはＰｒｏであり；
第３０位のＸａａはＩｌｅまたはＶａｌであり；
第５０位のＸａａはＡｒｇ、Ｇｌｎ、またはＬｙｓであり；
第８８位のＸａａはＶａｌまたはＬｅｕであり；
第１０５位のＸａａはＧｌｎまたはＧｌｙであり；
第１０８位のＸａａはＬｙｓまたはＡｒｇであり；ならびに、
第１０９位のＸａａはＶａｌまたはＬｅｕである］
および以下の配列を含む重鎖可変領域：
【数１２】
第１位のＸａａはＧｌｕまたはＧｌｎであり；
第７位のＸａａはＳｅｒまたはＬｅｕであり；
第４６位のＸａａはＧｌｕ、Ｖａｌ、Ａｓｐ、またはＳｅｒであり；
第６３位のＸａａはＴｈｒまたはＳｅｒであり；
第７５位のＸａａはＡｌａ、Ｓｅｒ、Ｖａｌ、またはＴｈｒであり；
第７６位のＸａａはＬｙｓまたはＡｒｇであり；
第８９位のＸａａはＧｌｕまたはＡｓｐであり；ならびに、
第１０７位のＸａａはＬｅｕまたはＴｈｒである］
を含む、請求項１ に記載のヒト化抗体またはその断片。
【請求項４】 配列番号９に記載の配列の軽鎖可変領域および配列番号１０に記載の重鎖可変領域を有する、請求項１ に記載のヒト化抗体またはその断片。
【請求項５】 配列番号１１に記載の配列の軽鎖および配列番号１２に記載の配列の重鎖を有する、請求項４に記載のヒト化抗体またはその断片。
【請求項６】 請求項１〜５のいずれかに記載のヒト化抗体の 抗体断片。
【請求項７】 適当な宿主細胞内で発現された場合に、請求項１〜６のいずれかに記載の抗体を産生する、１またはそれ以上のポリ核酸。
【請求項８】 請求項１〜６のいずれかに記載の抗体 を発現するための発現ベクターであって、該抗体または断片をコードするポリヌクレオチド配列を含む発現ベクター。
【請求項９】 請求項１〜６のいずれかに記載のヒト化抗体または断片を発現することができる細胞。
【請求項１０】 請求項１〜６のいずれかに記載のヒト化抗体または断片および製薬的に許容される賦形剤を含む医薬組成物。
【請求項１１】 ヒト被検体におけるアミロイドプラークの形成または毒性の可溶性Ａβ種の作用を阻害し、アミロイドプラークまたは毒性の可溶性Ａβ種の作用を減少させ、認識減退を逆転させ、認識減退を予防し、または認識を改善させる方法であって、 ヒト被検体に、請求項１〜６のいずれかに記載のヒト化抗体またはその断片の有効量を投与することを含む方法。
【請求項１２】 臨床的または前臨床的なアルツハイマー疾患、ダウン症候群、または臨床的または前臨床的な脳性アミロイド血管障害と診断されたヒト被検体における臨床的または前臨床的なアルツハイマー疾患、ダウン症候群、または臨床的または前臨床的な脳性アミロイド血管障害を治療する方法であって、該ヒト被検体に、請求項１〜６のいずれかに記載のヒト化抗体またはその断片の有効量を投与することを含む方法。
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18460100P | 2000-02-24 | 2000-02-24 | |
| US60/184,601 | 2000-02-24 | ||
| US25449800P | 2000-12-08 | 2000-12-08 | |
| US25446500P | 2000-12-08 | 2000-12-08 | |
| US60/254,465 | 2000-12-08 | ||
| US60/254,498 | 2000-12-08 | ||
| PCT/US2001/006191 WO2001062801A2 (en) | 2000-02-24 | 2001-02-26 | Humanized antibodies that sequester amyloid beta peptide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008240971A Division JP4914412B2 (ja) | 2000-02-24 | 2008-09-19 | Ａβペプチドを隔離するヒト化抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003523764A JP2003523764A (ja) | 2003-08-12 |
| JP2003523764A5 true JP2003523764A5 (ja) | 2008-04-10 |
| JP4738696B2 JP4738696B2 (ja) | 2011-08-03 |
Family
ID=27391859
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001562582A Expired - Lifetime JP4738696B2 (ja) | 2000-02-24 | 2001-02-26 | Ａβペプチドを隔離するヒト化抗体 |
| JP2008240971A Expired - Lifetime JP4914412B2 (ja) | 2000-02-24 | 2008-09-19 | Ａβペプチドを隔離するヒト化抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008240971A Expired - Lifetime JP4914412B2 (ja) | 2000-02-24 | 2008-09-19 | Ａβペプチドを隔離するヒト化抗体 |
Country Status (32)
| Country | Link |
|---|---|
| US (4) | US7195761B2 (ja) |
| EP (4) | EP1481992B1 (ja) |
| JP (2) | JP4738696B2 (ja) |
| KR (1) | KR100767146B1 (ja) |
| CN (3) | CN101670105B (ja) |
| AT (1) | ATE279442T1 (ja) |
| AU (1) | AU4178601A (ja) |
| BR (1) | BRPI0108676B8 (ja) |
| CA (1) | CA2400559C (ja) |
| CY (1) | CY1118381T1 (ja) |
| CZ (2) | CZ2008595A3 (ja) |
| DE (2) | DE60106394T3 (ja) |
| DK (2) | DK1257584T4 (ja) |
| DZ (1) | DZ3295A1 (ja) |
| EA (1) | EA006606B1 (ja) |
| ES (2) | ES2611427T3 (ja) |
| HK (1) | HK1048640B (ja) |
| HR (2) | HRP20020693B1 (ja) |
| HU (2) | HUP0204074A3 (ja) |
| IL (3) | IL151378A0 (ja) |
| LT (1) | LT1481992T (ja) |
| MX (1) | MXPA02008145A (ja) |
| NO (2) | NO329840B1 (ja) |
| NZ (1) | NZ520800A (ja) |
| PL (2) | PL210157B1 (ja) |
| PT (2) | PT1257584E (ja) |
| SI (2) | SI1481992T1 (ja) |
| SK (2) | SK288711B6 (ja) |
| TR (1) | TR200202799T3 (ja) |
| UA (1) | UA75881C2 (ja) |
| WO (1) | WO2001062801A2 (ja) |
| ZA (1) | ZA200206712B (ja) |
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|---|---|---|---|---|
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| US7179892B2 (en) * | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US20050059802A1 (en) * | 1998-04-07 | 2005-03-17 | Neuralab Ltd | Prevention and treatment of amyloidogenic disease |
| US20030147882A1 (en) | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
| US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
| UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
| CA2376693C (en) | 1999-06-16 | 2013-09-10 | Boston Biomedical Research Institute | Immunological control of .beta.-amyloid levels in vivo |
| IL151378A0 (en) | 2000-02-24 | 2003-04-10 | Univ Washington | Humanized antibodies that sequester amyloid beta peptide |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| PE20020574A1 (es) * | 2000-12-06 | 2002-07-02 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido amiloideo beta |
| WO2002088307A2 (en) * | 2001-04-30 | 2002-11-07 | Eli Lilly And Company | Humanized antibodies |
| DE60230736D1 (de) * | 2001-04-30 | 2009-02-26 | Lilly Co Eli | HUMANISIERTE ANTIKÖRPER DIE DAS BETA-AMYLOID PEPTID ERKENNEN& x9; |
| WO2003000714A2 (en) * | 2001-06-22 | 2003-01-03 | Panacea Pharmaceuticals, Inc. | Compositions and methods for preventing protein aggregation in neurodegenerative diseases |
| EP1420032B2 (en) † | 2001-08-03 | 2015-12-16 | Medical & Biological Laboratories Co., Ltd. | Antibody recognizing gm1 ganglioside-bound amyloid beta-protein and dna encoding the antibody |
| EP1519740A4 (en) * | 2001-08-17 | 2005-11-09 | Lilly Co Eli | FASTER IMPROVEMENT OF COGNITION IN DISEASES ASSOCIATED WITH A-BETA |
| EP1944040B1 (en) * | 2001-08-17 | 2012-08-01 | Washington University | Assay method for Alzheimer's disease |
| JP2005500389A (ja) * | 2001-08-17 | 2005-01-06 | イーライ・リリー・アンド・カンパニー | Ａβに関連する病態および疾患を治療するための、可溶性Ａβに高い親和性を有する抗体の使用 |
| JP2005503789A (ja) * | 2001-08-17 | 2005-02-10 | イーライ・リリー・アンド・カンパニー | 抗Ａβ抗体 |
| EP1416965B8 (en) * | 2001-08-17 | 2008-02-13 | Washington University | Assay method for alzheimer's disease |
| US7179606B2 (en) * | 2001-11-23 | 2007-02-20 | Syn X Pharma, Inc. | IG heavy chain, IG kappa, IG lambda biopolymer markers predictive of Alzheimer's disease |
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