JP2003508447A5 - - Google Patents
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- JP2003508447A5 JP2003508447A5 JP2001520142A JP2001520142A JP2003508447A5 JP 2003508447 A5 JP2003508447 A5 JP 2003508447A5 JP 2001520142 A JP2001520142 A JP 2001520142A JP 2001520142 A JP2001520142 A JP 2001520142A JP 2003508447 A5 JP2003508447 A5 JP 2003508447A5
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15101899P | 1999-08-27 | 1999-08-27 | |
| US60/151,018 | 1999-08-27 | ||
| US21382200P | 2000-06-23 | 2000-06-23 | |
| US60/213,822 | 2000-06-23 | ||
| PCT/US2000/023391 WO2001015730A1 (en) | 1999-08-27 | 2000-08-25 | DOSAGES FOR TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011151346A Division JP5818545B2 (ja) | 1999-08-27 | 2011-07-08 | 抗ＥｒｂＢ２抗体を用いた治療のためのドーセージ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003508447A JP2003508447A (ja) | 2003-03-04 |
| JP2003508447A5 true JP2003508447A5 (https=) | 2007-11-01 |
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Families Citing this family (147)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
| US6801686B2 (en) | 1997-06-06 | 2004-10-05 | Novera Optics, Inc. | Methods and apparatus for measuring the power spectrum of optical signals |
| ZA9811162B (en) * | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| US20030224001A1 (en) * | 1998-03-19 | 2003-12-04 | Goldstein Neil I. | Antibody and antibody fragments for inhibiting the growth of tumors |
| ZA200007412B (en) * | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
| HK1047236A1 (zh) * | 1999-05-14 | 2003-02-14 | Imclone Llc | 用表皮生长因子受体拮抗剂治疗难治的人肿瘤 |
| CA2376596C (en) * | 1999-06-25 | 2009-10-06 | Genentech, Inc. | Humanized anti-erbb2 antibodies and treatment with anti-erbb2 antibodies |
| US20040013667A1 (en) * | 1999-06-25 | 2004-01-22 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| US7041292B1 (en) | 1999-06-25 | 2006-05-09 | Genentech, Inc. | Treating prostate cancer with anti-ErbB2 antibodies |
| US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| US20030086924A1 (en) * | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| EP1191944A2 (en) | 1999-06-25 | 2002-04-03 | Genentech, Inc. | METHODS OF TREATMENT USING ANTI-ErbB ANTIBODY-MAYTANSINOID CONJUGATES |
| TR200200472T2 (tr) | 1999-08-27 | 2002-06-21 | Genentech, Inc. | Anti-Erb B2 antikorları ile tedavi için dozajlar |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US7294695B2 (en) * | 2000-01-20 | 2007-11-13 | Genentech, Inc. | PRO10268 polypeptides |
| US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| WO2001083781A2 (en) * | 2000-04-28 | 2001-11-08 | Millennium Pharmaceuticals, Inc. | 14094, a novel human trypsin family member and uses thereof |
| KR20130056201A (ko) * | 2000-05-19 | 2013-05-29 | 제넨테크, 인크. | ＥｒｂＢ 길항제에 의한 암 치료요법에 대한 효과적인 반응의 가능성을 개선시키기 위한 유전자 검출 분석 |
| AU9500201A (en) * | 2000-08-09 | 2002-02-18 | Imclone Systems Inc | Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists |
| US20080008704A1 (en) * | 2001-03-16 | 2008-01-10 | Mark Rubin | Methods of treating colorectal cancer with anti-epidermal growth factor antibodies |
| JP2005508838A (ja) | 2001-03-23 | 2005-04-07 | アフトン コーポレーション | 膵癌の組合せ治療 |
| WO2002081649A2 (en) * | 2001-04-06 | 2002-10-17 | The Trustees Of The University Of Pennsylvania | ErbB INTERFACE PEPTIDOMIMETICS AND METHODS OF USE THEREOF |
| WO2002085405A2 (en) * | 2001-04-24 | 2002-10-31 | Merck Patent Gmbh | COMBINATION THERAPY USING ANTI-ANGIOGENIC AGENTS AND TNF$g(a) |
| US20090191232A1 (en) | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
| JP2004528368A (ja) * | 2001-05-08 | 2004-09-16 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 抗ｅｇｆｒ抗体と抗ホルモン剤を用いた組合せ療法 |
| JP2004536835A (ja) * | 2001-07-09 | 2004-12-09 | アフトン コーポレーション | 肝臓、肺および食道の癌性ならびに前癌性状態の治療および防止 |
| AU2002326531A1 (en) * | 2001-08-03 | 2003-02-17 | The Trustees Of The University Of Pennsylvania | Monoclonal antibodies to activated erbb family members and methods of use thereof |
| EP1283053A1 (en) | 2001-08-09 | 2003-02-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibitors of HER3 activity |
| GB0121811D0 (en) | 2001-09-10 | 2001-10-31 | Cit Alcatel | Branching unit for an optical transmission system |
| GB2397018B (en) * | 2001-10-26 | 2006-05-31 | Altarex Medical Corp | Combination therapy for treating disease |
| WO2003037373A1 (en) * | 2001-10-31 | 2003-05-08 | Medical Research Council | Use of an ep2 or ep4 receptor antagonist and/or a cox-1 inhibitor for treating cervical cancer |
| DE10163459A1 (de) * | 2001-12-21 | 2003-07-03 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor |
| US7402397B2 (en) | 2002-05-21 | 2008-07-22 | Monogram Biosciences, Inc. | Detecting and profiling molecular complexes |
| US20040229294A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
| EP1513543B1 (en) | 2002-05-23 | 2010-10-06 | The Trustees of The University of Pennsylvania | Fas peptide mimetics and uses thereof |
| EP1513879B1 (en) * | 2002-06-03 | 2018-08-22 | Genentech, Inc. | Synthetic antibody phage libraries |
| ES2392525T3 (es) * | 2002-07-15 | 2012-12-11 | F. Hoffmann-La Roche Ag | Tratamiento del cáncer con el anticuerpo dirigido contra ErbB2 rhuMAb 2C4 |
| AU2002951853A0 (en) * | 2002-10-04 | 2002-10-24 | Commonwealth Scientific And Industrial Research Organisation | Crystal structure of erbb2 and uses thereof |
| JP2006516117A (ja) * | 2002-11-21 | 2006-06-22 | ジェネンテック・インコーポレーテッド | 抗ＥｒｂＢ２抗体を用いた非悪性疾病または疾患の治療 |
| CA2510003A1 (en) * | 2003-01-16 | 2004-08-05 | Genentech, Inc. | Synthetic antibody phage libraries |
| WO2004069872A1 (en) * | 2003-02-06 | 2004-08-19 | Novozymes A/S | Human heavy chain antibody expression in filamentous fungi |
| EP1622941A2 (en) * | 2003-03-20 | 2006-02-08 | ImClone Systems Incorporated | Method of producing an antibody to epidermal growth factor receptor |
| JP4689597B2 (ja) * | 2003-03-28 | 2011-05-25 | レセプター バイオロジックス インク． | ガストリンホルモン免疫アッセイ |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| CN102408483B (zh) * | 2003-07-15 | 2016-06-08 | 安姆根有限公司 | 作为选择性ngf途径抑制剂的人抗ngf中和抗体 |
| CA2534055A1 (en) * | 2003-08-01 | 2005-02-10 | Genentech, Inc. | Antibody cdr polypeptide sequences with restricted diversity |
| EP1681983A4 (en) * | 2003-10-14 | 2008-12-10 | Monogram Biosciences Inc | RECEPTOR TYROSINE KINASE SIGNAL PATH ANALYSIS FOR DIAGNOSIS AND THERAPY |
| EP1677773A1 (en) * | 2003-10-14 | 2006-07-12 | Biomira, Inc. | Combination therapy for cancer |
| US7572443B2 (en) * | 2003-11-13 | 2009-08-11 | California Pacific Medical Center | Anti-PECAM therapy for metastasis suppression |
| WO2005047536A2 (en) * | 2003-11-13 | 2005-05-26 | Novartis Ag | Detection of genomic amplification and deletion in cancer |
| CN1925871A (zh) * | 2004-01-27 | 2007-03-07 | 南加州大学 | 聚合物结合的抗体癌症治疗剂 |
| EP2332990A1 (en) * | 2004-03-19 | 2011-06-15 | Imclone LLC | Human anti-epidermal growth factor receptor antibody |
| TWI439284B (zh) | 2004-04-09 | 2014-06-01 | 艾伯維生物技術有限責任公司 | 用於治療ＴＮＦα相關失調症之多重可變劑量療法 |
| US7785903B2 (en) * | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
| SV2006002143A (es) * | 2004-06-16 | 2006-01-26 | Genentech Inc | Uso de un anticuerpo para el tratamiento del cancer resistente al platino |
| KR101699142B1 (ko) | 2004-06-18 | 2017-01-23 | 암브룩스, 인코포레이티드 | 신규 항원-결합 폴리펩티드 및 이의 용도 |
| ME00226B (me) | 2004-07-15 | 2011-02-10 | Medarex Llc | Humana anti-ngf neutrališuća antitijela kao selektivni inhibitori ngf signalne kaskade |
| KR20140032004A (ko) | 2004-07-22 | 2014-03-13 | 제넨테크, 인크. | Ｈｅｒ２ 항체 조성물 |
| KR101333168B1 (ko) | 2004-09-22 | 2013-11-28 | 리셉터 바이오로직스 인크 | 프로가스트린에 대한 모노클로날 항체 |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| JP2008523073A (ja) * | 2004-12-07 | 2008-07-03 | ジェネンテック・インコーポレーテッド | Ｈｅｒ阻害剤を用いた治療のための患者の選択 |
| EP1825003A4 (en) * | 2004-12-15 | 2009-05-06 | Nsabp Foundation Inc | IDENTIFICATION AND USE OF PROGNOSTIC AND PREDICTIVE MARKERS IN CANCER TREATMENT |
| CA2592177A1 (en) | 2005-01-21 | 2006-07-27 | Genentech, Inc. | Fixed dosing of her antibodies |
| RU2007133660A (ru) * | 2005-02-09 | 2009-03-20 | Дженентек, Инк. (Us) | Ингибирование шеддинга her2 антагонистами матриксной металлопротеиназы |
| EP1850874B1 (en) | 2005-02-23 | 2013-10-16 | Genentech, Inc. | Extending time to disease progression or survival in ovarian cancer patients using pertuzumab |
| JP2006316040A (ja) * | 2005-05-13 | 2006-11-24 | Genentech Inc | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| PE20070207A1 (es) * | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
| EP1957531B1 (en) | 2005-11-07 | 2016-04-13 | Genentech, Inc. | Binding polypeptides with diversified and consensus vh/vl hypervariable sequences |
| WO2007064919A2 (en) * | 2005-12-02 | 2007-06-07 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| AR056857A1 (es) | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos |
| JP2009536527A (ja) * | 2006-05-09 | 2009-10-15 | ジェネンテック・インコーポレーテッド | 最適化されたスキャフォールドを備えた結合ポリペプチド |
| EP1913958B1 (en) * | 2006-08-03 | 2009-12-23 | Sanofi-Aventis | Antitumor compositions containing acetylcyclopropyl docetaxel and trastuzumab |
| SG178789A1 (en) * | 2007-02-16 | 2012-03-29 | Merrimack Pharmaceuticals Inc | Antibodies against erbb3 and uses thereof |
| MX2009008981A (es) | 2007-03-02 | 2009-09-02 | Genentech Inc | Prediccion de respuesta a un inhibidor her. |
| US20090304590A1 (en) * | 2007-05-29 | 2009-12-10 | Wyeth | Therapeutic compositions and methods |
| US20090258005A1 (en) * | 2007-05-29 | 2009-10-15 | Trubion Pharmaceuticals Inc. | Therapeutic compositions and methods |
| EP2171090B1 (en) | 2007-06-08 | 2013-04-03 | Genentech, Inc. | Gene expression markers of tumor resistance to her2 inhibitor treatment |
| US9551033B2 (en) | 2007-06-08 | 2017-01-24 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
| US20100254996A1 (en) * | 2007-06-18 | 2010-10-07 | Medimmune, Llc | Synergistic treatment of cells that express epha2 and erbb2 |
| JP5695905B2 (ja) * | 2007-10-02 | 2015-04-08 | ジェネンテック， インコーポレイテッド | Ｎｌｒｒ−１アンタゴニスト及びその使用 |
| CA2711843C (en) | 2007-12-20 | 2018-11-13 | Laboratory Corporation Of America Holdings | Her-2 diagnostic methods |
| US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
| CA2711256C (en) | 2008-01-03 | 2019-01-15 | The Scripps Research Institute | Antibody targeting through a modular recognition domain |
| US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物 |
| NZ602675A (en) | 2008-03-18 | 2014-03-28 | Genentech Inc | Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use |
| CN107325182A (zh) * | 2008-04-02 | 2017-11-07 | 宏观基因有限公司 | HER2/neu‑特异性抗体和其使用方法 |
| ES2342646B1 (es) * | 2008-06-02 | 2011-04-26 | Institut De Recerca Hospital Universitari Vall Hebron | Metodo de diagnostico de canceres que expresan el receptor her-2 o sus variantes truncadas. |
| BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
| UA104868C2 (uk) * | 2008-08-15 | 2014-03-25 | Меррімак Фармасьютікалз, Інк. | Спосіб лікування пацієнта, що має неопластичну пухлину, відповідно до спрогнозованої реакції |
| US9207242B2 (en) * | 2008-10-09 | 2015-12-08 | The University Of Hong Kong | Cadherin-17 as diagnostic marker and therapeutic target for liver cancer |
| AU2009308707A1 (en) * | 2008-10-31 | 2010-05-06 | Biogen Idec Ma Inc. | LIGHT targeting molecules and uses thereof |
| US8470542B2 (en) | 2008-12-01 | 2013-06-25 | Laboratory Corporation Of America Holdings | Methods and assays for measuring p95 and/or p95 complexes in a sample and antibodies specific for p95 |
| SG172983A1 (en) | 2009-01-15 | 2011-08-29 | Lab Corp America Holdings | Methods of determining patient response by measurement of her-3 |
| CN104447995A (zh) | 2009-03-20 | 2015-03-25 | 霍夫曼-拉罗奇有限公司 | 双特异性抗-her抗体 |
| EP2435071A1 (en) | 2009-05-29 | 2012-04-04 | F. Hoffmann-La Roche AG | Modulators for her2 signaling in her2 expressing patients with gastric cancer |
| US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
| ES2612001T4 (es) | 2009-08-20 | 2018-02-07 | Yeda Research & Development Company, Ltd. | Terapia de baja frecuencia con acetato de glatirámero |
| CA2778084A1 (en) * | 2009-10-23 | 2011-04-28 | Garvan Institute Of Medical Research | Modified variable domain molecules and methods for producing and using same |
| US8658434B2 (en) * | 2009-10-28 | 2014-02-25 | Biotium, Inc. | Fluorescent pyrene compounds |
| MX358013B (es) | 2009-11-13 | 2018-08-01 | Amgen Inc | Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3. |
| DK2536748T3 (da) | 2010-02-18 | 2014-10-13 | Genentech Inc | Neuregulin-antagonister og anvendelse deraf ved behandling af kræft |
| CA2792327C (en) | 2010-03-11 | 2019-09-24 | Merrimack Pharmaceuticals, Inc. | Use of erbb3 inhibitors in the treatment of triple negative and basal-like breast cancers |
| WO2011146568A1 (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
| US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| US20130245233A1 (en) | 2010-11-24 | 2013-09-19 | Ming Lei | Multispecific Molecules |
| JP5766296B2 (ja) | 2010-12-23 | 2015-08-19 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用 |
| EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| US20140363438A1 (en) | 2011-08-17 | 2014-12-11 | Genentech, Inc. | Neuregulin antibodies and uses thereof |
| WO2013055874A2 (en) | 2011-10-14 | 2013-04-18 | Genentech, Inc. | Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab |
| WO2013063229A1 (en) | 2011-10-25 | 2013-05-02 | The Regents Of The University Of Michigan | Her2 targeting agent treatment in non-her2-amplified cancers having her2 expressing cancer stem cells |
| US9441042B2 (en) * | 2011-11-02 | 2016-09-13 | Apexigen, Inc. | Anti-KDR antibodies and methods of use |
| RU2014126098A (ru) | 2011-11-30 | 2016-01-27 | Дженентек, Инк. | МУТАЦИИ ErbB3 ПРИ РАКЕ |
| US9376715B2 (en) | 2011-12-09 | 2016-06-28 | Roche Molecular Systems, Inc | Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene |
| RU2014136886A (ru) | 2012-03-27 | 2016-05-20 | Дженентек, Инк. | Диагностика и виды лечения, связанные с ингибиторами her3 |
| WO2013173255A2 (en) | 2012-05-17 | 2013-11-21 | Sorrento Therapeutics Inc. | Antigen binding proteins that bind egfr |
| WO2013182668A1 (en) | 2012-06-08 | 2013-12-12 | F. Hoffmann-La Roche Ag | Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer |
| WO2014028221A1 (en) | 2012-07-31 | 2014-02-20 | Crown Bioscience, Inc. | Histological markers for identifying non-small cell lung carcinoma patients for treatment with an anti-egfr drug |
| KR102291355B1 (ko) | 2012-11-30 | 2021-08-19 | 에프. 호프만-라 로슈 아게 | Pd-l1 억제제 공동치료를 필요로 하는 환자의 식별방법 |
| BR112015023752B1 (pt) | 2013-03-15 | 2023-11-14 | Zyngenia, Inc. | Domínio de reconhecimento modular (mrd), complexo compreendendo mrd e cetuximabe, usos do complexo para inibir a angiogênese e tratar câncer e composição farmacêutica compreendendo o dito complexo |
| RU2019115089A (ru) | 2013-04-16 | 2019-06-11 | Дженентек, Инк. | Варианты пертузумаба и их аналитическая характеристика |
| HRP20250551T1 (hr) | 2013-11-27 | 2025-06-20 | Zymeworks Bc Inc. | Bispecifični antigen-vezujući konstrukti koji ciljaju her2 |
| EP3087394A2 (en) | 2013-12-27 | 2016-11-02 | Merrimack Pharmaceuticals, Inc. | Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies |
| JP2017513901A (ja) | 2014-04-25 | 2017-06-01 | ジェネンテック， インコーポレイテッド | トラスツズマブ−ｍｃｃ−ｄｍ１及びペルツズマブにより早期の乳癌を処置する方法 |
| EP3223848B1 (en) | 2014-11-27 | 2024-11-27 | Zymeworks BC Inc. | Methods of using bispecific antigen-binding constructs targeting her2 |
| US20160257761A1 (en) * | 2015-03-06 | 2016-09-08 | Macrogenics, Inc. | HER2/neu-Specific Antibodies and Methods of Using Same |
| US11406715B2 (en) | 2015-05-30 | 2022-08-09 | Genentech, Inc. | Methods of treating HER2-positive metastatic breast cancer |
| US10184006B2 (en) | 2015-06-04 | 2019-01-22 | Merrimack Pharmaceuticals, Inc. | Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors |
| WO2017070475A1 (en) * | 2015-10-22 | 2017-04-27 | Merrimack Pharmaceuticals, Inc. | Methods of treating cancer by administering a mek inhibitor and a combination of anti-egfr antibodies |
| WO2017087280A1 (en) | 2015-11-16 | 2017-05-26 | Genentech, Inc. | Methods of treating her2-positive cancer |
| WO2017194554A1 (en) | 2016-05-10 | 2017-11-16 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Combinations therapies for the treatment of cancer |
| AU2017355432A1 (en) | 2016-11-04 | 2019-05-16 | F. Hoffmann-La Roche Ag | Treatment of HER2-positive breast cancer |
| AU2017387909A1 (en) | 2016-12-28 | 2019-06-27 | Genentech, Inc. | Treatment of advanced HER2 expressing cancer |
| SG11201905622VA (en) | 2017-01-17 | 2019-08-27 | Genentech Inc | Subcutaneous her2 antibody formulations |
| US11077189B2 (en) | 2017-03-02 | 2021-08-03 | Genentech Inc. | Adjuvant treatment of HER2-positive breast cancer |
| EP3615695A1 (en) | 2017-04-24 | 2020-03-04 | Genentech, Inc. | Erbb2/her2 mutations in the transmebrane or juxtamembrane domain |
| WO2018232230A1 (en) | 2017-06-15 | 2018-12-20 | Cancer Advances Inc. | Compositions and methods for inducing humoral and cellular immunities against tumors and cancer |
| US12150978B2 (en) | 2017-06-15 | 2024-11-26 | Cancer Advances Inc. | Compositions and methods for preventing tumors and cancer |
| WO2019131727A1 (ja) * | 2017-12-27 | 2019-07-04 | コニカミノルタ株式会社 | 医薬の評価方法 |
| US20220411516A1 (en) * | 2019-11-07 | 2022-12-29 | Amgen Inc. | Dosage regimen for anti-egfrviii agents |
| KR20220133238A (ko) | 2020-01-29 | 2022-10-04 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | Nrg1 융합체가 있는 암의 치료를 위한 포지오티닙의 용도 |
| US20230112470A1 (en) | 2020-01-29 | 2023-04-13 | Board Of Regents, The University Of Texas System | Use of egfr/her2 tyrosine kinase inhibitors and/or her2/her3 antibodies for the treatment of cancers with nrg1 fusions |
| AU2020456731A1 (en) | 2020-06-29 | 2023-01-05 | F. Hoffmann-La Roche Ag | Pertuzumab plus trastuzumab fixed dose combination |
| IL303350A (en) | 2020-12-04 | 2023-08-01 | Macrogenics Inc | Pharmaceutical compositions of a her2/neu antibody and use of the same |
Family Cites Families (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US474727A (en) | 1892-05-10 | Railway frog | ||
| US503556A (en) | 1893-08-15 | Apparatus for treating pulverulent materials with gases | ||
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| WO1981001145A1 (en) | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
| US4935341A (en) | 1986-06-04 | 1990-06-19 | Whitehead Institute For Biomedical Research | Detection of point mutations in neu genes |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5169774A (en) | 1984-02-08 | 1992-12-08 | Cetus Oncology Corporation | Monoclonal anti-human breast cancer antibodies |
| US6054561A (en) | 1984-02-08 | 2000-04-25 | Chiron Corporation | Antigen-binding sites of antibody molecules specific for cancer antigens |
| US4753894A (en) | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| JPH06982B2 (ja) | 1984-07-14 | 1994-01-05 | 日本ソリツド株式会社 | 取水排水装置 |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| JPH076982B2 (ja) | 1985-11-06 | 1995-01-30 | 株式会社ニチレイ | 抗 体 |
| US7838216B1 (en) | 1986-03-05 | 2010-11-23 | The United States Of America, As Represented By The Department Of Health And Human Services | Human gene related to but distinct from EGF receptor gene |
| US5401638A (en) | 1986-06-04 | 1995-03-28 | Oncogene Science, Inc. | Detection and quantification of neu related proteins in the biological fluids of humans |
| US4968603A (en) | 1986-12-31 | 1990-11-06 | The Regents Of The University Of California | Determination of status in neoplastic disease |
| GB8705477D0 (en) | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| US5720937A (en) | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
| JP2761543B2 (ja) | 1988-08-17 | 1998-06-04 | 味の素株式会社 | ヒト癌原遺伝子産物に対するモノクローナル抗体及びそれを産生するハイブリドーマ |
| DE69031120T2 (de) | 1989-05-19 | 1998-01-15 | Genentech, Inc., South San Francisco, Calif. | Her2 extrazellulare domäne |
| US5055393A (en) * | 1989-06-13 | 1991-10-08 | Salk Institute Biotechnology/Industrial Associates, Inc. | Prenatal sex determination of bovine cells using male-specific oligonucleotides |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| ES2096590T3 (es) | 1989-06-29 | 1997-03-16 | Medarex Inc | Reactivos biespecificos para la terapia del sida. |
| US5705157A (en) | 1989-07-27 | 1998-01-06 | The Trustees Of The University Of Pennsylvania | Methods of treating cancerous cells with anti-receptor antibodies |
| US6884418B1 (en) | 1989-08-04 | 2005-04-26 | Berlex Laboratories, Inc. | Use of ligand-mimicking agents and anti-neoplastic drugs in cancer therapy |
| JP2895105B2 (ja) | 1989-09-14 | 1999-05-24 | 株式会社ニチレイ | ｃ‐ｅｒｂＢ‐２癌遺伝子産物をイムノアッセイする乳癌の血清診断法とそのキット |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5183884A (en) | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
| JPH03240498A (ja) | 1990-02-16 | 1991-10-25 | Nobuyoshi Shimizu | 抗体およびそれを使用した免疫分析方法 |
| WO1991015230A1 (en) | 1990-04-06 | 1991-10-17 | The Trustees Of The University Of Pennsylvania | Ligand for the neu gene product |
| US5578482A (en) | 1990-05-25 | 1996-11-26 | Georgetown University | Ligand growth factors that bind to the erbB-2 receptor protein and induce cellular responses |
| DE69132709T2 (de) | 1990-06-29 | 2002-06-20 | Large Scale Biology Corp., Vacaville | Melaninproduktion durch transformierte mikroorganismen |
| US5643567A (en) | 1990-12-04 | 1997-07-01 | Board Of Regents, The University Of Texas System | Methods for the suppression of neu mediated tumors by adenoviral E1A and SV40 large T antigen |
| EP0560932B1 (en) | 1990-12-04 | 1996-09-04 | The Board Of Regents, The University Of Texas System | Methods and compositions for the suppression of neu mediated transformation |
| DE69123241T2 (de) | 1990-12-14 | 1997-04-17 | Cell Genesys Inc | Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen |
| EP0586505A1 (en) | 1991-05-14 | 1994-03-16 | Repligen Corporation | Heteroconjugate antibodies for treatment of hiv infection |
| IL101943A0 (en) | 1991-05-24 | 1992-12-30 | Genentech Inc | Structure,production and use of heregulin |
| US5367060A (en) | 1991-05-24 | 1994-11-22 | Genentech, Inc. | Structure, production and use of heregulin |
| US5834229A (en) | 1991-05-24 | 1998-11-10 | Genentech, Inc. | Nucleic acids vectors and host cells encoding and expressing heregulin 2-α |
| JPH0759588A (ja) | 1991-05-31 | 1995-03-07 | Kokuritsu Gan Center Souchiyou | 増殖因子レセプターに対するモノクローナル抗体の製造方法及び抗ｃ−ｅｒｂＢ−２モノクローナル抗体 |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5939531A (en) | 1991-07-15 | 1999-08-17 | Novartis Corp. | Recombinant antibodies specific for a growth factor receptor |
| US5288477A (en) | 1991-09-27 | 1994-02-22 | Becton, Dickinson And Company | Method for prognosticating response to cancer therapy |
| JPH05117165A (ja) | 1991-10-24 | 1993-05-14 | Masakazu Ueda | 抗癌剤 |
| JPH05317084A (ja) | 1991-10-30 | 1993-12-03 | Idemitsu Kosan Co Ltd | 抗体産生ヒト由来リンパ球及びヒトモノクローナル抗体の製造方法並びに該方法により作製されたヒトモノクロ−ナル抗体 |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| DE69232137T2 (de) | 1991-11-25 | 2002-05-29 | Enzon Inc | Multivalente antigen-bindende proteine |
| AU3236793A (en) | 1991-12-12 | 1993-07-19 | Berlex Laboratories, Inc. | Recombinant and chimeric antibodies to c-erbB-2 |
| JPH05170667A (ja) | 1991-12-26 | 1993-07-09 | Kyowa Hakko Kogyo Co Ltd | バイスペシフィック抗体 |
| JPH05213775A (ja) | 1992-02-05 | 1993-08-24 | Otsuka Pharmaceut Co Ltd | Ｂｆａ抗体 |
| AU675929B2 (en) | 1992-02-06 | 1997-02-27 | Curis, Inc. | Biosynthetic binding protein for cancer marker |
| US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
| WO1993021319A1 (en) | 1992-04-08 | 1993-10-28 | Cetus Oncology Corporation | HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES |
| ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
| EP0655924A4 (en) | 1992-06-30 | 1996-09-11 | Oncologix Inc | A COMBINATION OF MONOCLONAL ANTIBODIES AGAINST erbB-2 AND METHOD FOR THEIR USE. |
| JPH076982A (ja) | 1992-07-31 | 1995-01-10 | Sharp Corp | 薄層半導体基板の分割方法 |
| EP0656064B1 (en) | 1992-08-17 | 1997-03-05 | Genentech, Inc. | Bispecific immunoadhesins |
| FR2697752B1 (fr) | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| MD1367C2 (ro) | 1992-11-13 | 2000-11-30 | Idec Pharmaceuticals Corporation | Metode de tratament al limfomului celulelor B, anticorpi anti-CD20, hibridom. |
| CA2103323A1 (en) | 1992-11-24 | 1994-05-25 | Gregory D. Plowman | Her4 human receptor tyrosine kinase |
| EP0612812B1 (en) | 1993-02-24 | 2001-07-11 | Ibiden Co, Ltd. | Resin composites and method for producing the same |
| US5869445A (en) | 1993-03-17 | 1999-02-09 | University Of Washington | Methods for eliciting or enhancing reactivity to HER-2/neu protein |
| US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| PT616812E (pt) | 1993-03-24 | 2000-04-28 | Berlex Biosciences | Combinacao de compostos anti-hormonais e moleculas de ligacao no tratamento do cancro |
| WO1994022478A1 (en) | 1993-03-30 | 1994-10-13 | The Trustees Of The University Of Pennsylvania | PREVENTION OF TUMORS WITH MONOCLONAL ANTIBODIES AGAINST $i(NEU) |
| WO1994028127A1 (en) | 1993-05-24 | 1994-12-08 | Imperial Cancer Research Technology Limited | Cancer treatment |
| US5430620A (en) | 1993-10-08 | 1995-07-04 | Cogent Light Technologies, Inc. | Compact surgical illumination system capable of dynamically adjusting the resulting field of illumination |
| US6365345B1 (en) | 1993-12-23 | 2002-04-02 | Biognostik Gesellscahft Für Biomokekulare Diagnostik mbH | Antisense nucleic acids for the prevention and treatment of disorders in which expression of c-erbB plays a role |
| US5518885A (en) | 1994-04-19 | 1996-05-21 | The United States Of America As Represented By The Department Of Health & Human Services | ERBB2 promoter binding protein in neoplastic disease |
| EP0758196A4 (en) | 1994-05-05 | 1999-05-06 | Univ Pennsylvania | COMPOSITIONS AND METHODS FOR TREATING TUMORS |
| US5910486A (en) | 1994-09-06 | 1999-06-08 | Uab Research Foundation | Methods for modulating protein function in cells using, intracellular antibody homologues |
| US6214388B1 (en) | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
| DE69504278T2 (de) | 1994-11-10 | 1999-05-06 | Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum, 72076 Tuebingen | Verfahren zur Wachstumshemmung von Leukämischen Zellen durch HER-2-Protein-Zeilen |
| AU712441B2 (en) | 1994-12-14 | 1999-11-04 | Scripps Research Institute, The | In vivo activation of tumor-specific cytotoxic T cells |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5663144A (en) | 1995-05-03 | 1997-09-02 | The Trustees Of The University Of Pennsylvania | Compounds that bind to p185 and methods of using the same |
| US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
| AU6267896A (en) | 1995-06-07 | 1996-12-30 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth oftumors |
| CA2245835A1 (en) | 1995-06-14 | 1997-01-03 | The Regents Of The University Of California | Novel high affinity human antibodies to tumor antigens |
| CA2226575C (en) | 1995-07-27 | 2011-10-18 | Genentech, Inc. | Stabile isotonic lyophilized protein formulation |
| US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US5783186A (en) | 1995-12-05 | 1998-07-21 | Amgen Inc. | Antibody-induced apoptosis |
| WO1997027848A1 (en) | 1996-01-31 | 1997-08-07 | Board Of Regents, The University Of Texas System | SENSITIZATION OF HER2/neu OVER-EXPRESSING CANCER CELLS TO CHEMOTHERAPEUTIC DRUGS |
| US5968511A (en) | 1996-03-27 | 1999-10-19 | Genentech, Inc. | ErbB3 antibodies |
| IL126303A (en) | 1996-03-27 | 2002-05-23 | Genentech Inc | ErbB3 ANTIBODIES |
| US5708156A (en) | 1996-05-31 | 1998-01-13 | Ilekis; John V. | Epidermal growth factor receptor-like gene product and its uses |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| CA2257839C (en) | 1996-07-12 | 2012-10-23 | Genentech, Inc. | Gamma-heregulin |
| US6193963B1 (en) * | 1996-10-17 | 2001-02-27 | The Regents Of The University Of California | Method of treating tumor-bearing patients with human plasma hyaluronidase |
| CN101412758A (zh) * | 1996-10-18 | 2009-04-22 | 基因技术股份有限公司 | 抗ErbB2抗体 |
| US5949245A (en) | 1997-02-01 | 1999-09-07 | Powership Semiconductor Corp. | Probe card with ground shield structure to minimize noise coupling effect during multiple-chip testing |
| US5994071A (en) | 1997-04-04 | 1999-11-30 | Albany Medical College | Assessment of prostate cancer |
| AU9805398A (en) | 1997-10-15 | 1999-05-03 | Children's Medical Center Corporation | Novel human egf receptors and use thereof |
| ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| JP2002507404A (ja) | 1998-03-27 | 2002-03-12 | ジェネンテク・インコーポレイテッド | Ａｐｏ−２リガンド−抗ＨＥＲ−２抗体相乗作用 |
| GB9828383D0 (en) * | 1998-12-22 | 1999-02-17 | Medical Res Council | Cell lineage markers |
| US6333348B1 (en) | 1999-04-09 | 2001-12-25 | Aventis Pharma S.A. | Use of docetaxel for treating cancers |
| CA2376596C (en) * | 1999-06-25 | 2009-10-06 | Genentech, Inc. | Humanized anti-erbb2 antibodies and treatment with anti-erbb2 antibodies |
| US20030086924A1 (en) | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| US20040013667A1 (en) | 1999-06-25 | 2004-01-22 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| TR200200472T2 (tr) | 1999-08-27 | 2002-06-21 | Genentech, Inc. | Anti-Erb B2 antikorları ile tedavi için dozajlar |
| US7563167B2 (en) | 2002-04-19 | 2009-07-21 | Walker Digital, Llc | Gaming device method and apparatus employing modified payouts |
| US8392173B2 (en) | 2003-02-10 | 2013-03-05 | At&T Intellectual Property I, L.P. | Message translations |
| EP1500399A1 (en) * | 2003-07-24 | 2005-01-26 | Institut Pasteur | Active or passive immunization against proapoptotic neurotrophins for the treatment or prevention of neurodegenerative deseases |
| JP6343496B2 (ja) | 2014-05-27 | 2018-06-13 | 日本発條株式会社 | 車両用シート |
| JP6823908B2 (ja) | 2014-09-10 | 2021-02-03 | キヤノン株式会社 | 情報処理装置、及びその制御方法 |
| WO2017087280A1 (en) * | 2015-11-16 | 2017-05-26 | Genentech, Inc. | Methods of treating her2-positive cancer |
| US11077189B2 (en) * | 2017-03-02 | 2021-08-03 | Genentech Inc. | Adjuvant treatment of HER2-positive breast cancer |
-
2000
- 2000-08-25 TR TR2002/00472T patent/TR200200472T2/xx unknown
- 2000-08-25 ES ES00959423T patent/ES2330301T3/es not_active Expired - Lifetime
- 2000-08-25 DE DE60042693T patent/DE60042693D1/de not_active Expired - Lifetime
- 2000-08-25 EP EP20090008314 patent/EP2110138A1/en not_active Withdrawn
- 2000-08-25 CA CA002382100A patent/CA2382100A1/en not_active Abandoned
- 2000-08-25 US US09/648,067 patent/US6627196B1/en not_active Expired - Lifetime
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- 2000-08-25 CN CNB008145903A patent/CN100443118C/zh not_active Ceased
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- 2000-08-25 HU HU0202523A patent/HU231064B1/hu unknown
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- 2000-08-25 WO PCT/US2000/023391 patent/WO2001015730A1/en not_active Ceased
- 2000-08-25 EP EP00959423A patent/EP1210115B1/en not_active Revoked
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- 2000-08-25 NZ NZ517150A patent/NZ517150A/en not_active IP Right Cessation
- 2000-08-25 MX MXPA02002037A patent/MXPA02002037A/es active IP Right Grant
- 2000-08-25 SI SI200031042T patent/SI1210115T1/sl unknown
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- 2002-02-12 IL IL148114A patent/IL148114A/en active IP Right Grant
-
2003
- 2003-06-20 US US10/600,152 patent/US7371379B2/en not_active Expired - Lifetime
-
2006
- 2006-01-13 AU AU2006200146A patent/AU2006200146B2/en not_active Expired
- 2006-05-31 US US11/443,943 patent/US20060210561A1/en not_active Abandoned
-
2009
- 2009-05-12 AU AU2009201871A patent/AU2009201871A1/en not_active Withdrawn
- 2009-09-28 CY CY20091101010T patent/CY1109421T1/el unknown
-
2011
- 2011-07-08 JP JP2011151346A patent/JP5818545B2/ja not_active Expired - Lifetime
-
2012
- 2012-03-08 US US13/415,271 patent/US20130149299A1/en not_active Abandoned
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2013
- 2013-05-10 JP JP2013100116A patent/JP2013209389A/ja active Pending
- 2013-11-06 US US14/073,659 patent/US10160811B2/en not_active Expired - Fee Related
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2014
- 2014-12-23 IL IL236404A patent/IL236404A0/en unknown
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2015
- 2015-01-06 JP JP2015000857A patent/JP2015110600A/ja not_active Withdrawn
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2016
- 2016-12-07 JP JP2016237937A patent/JP2017081944A/ja active Pending
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2017
- 2017-08-31 IL IL254264A patent/IL254264A/en unknown
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2018
- 2018-01-11 JP JP2018002753A patent/JP2018095651A/ja not_active Withdrawn
- 2018-10-29 US US16/173,216 patent/US20190055317A1/en not_active Abandoned
- 2018-11-12 US US16/186,756 patent/US10280228B2/en not_active Expired - Fee Related
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2019
- 2019-12-02 JP JP2019217932A patent/JP2020063266A/ja active Pending
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