|
US6395888B1
(en)
*
|
1996-02-01 |
2002-05-28 |
Gilead Sciences, Inc. |
High affinity nucleic acid ligands of complement system proteins
|
|
US5681811A
(en)
*
|
1993-05-10 |
1997-10-28 |
Protein Delivery, Inc. |
Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
|
|
KR100361933B1
(ko)
*
|
1993-09-08 |
2003-02-14 |
라 졸라 파마슈티칼 컴파니 |
화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
|
|
US5919455A
(en)
*
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5583114A
(en)
|
1994-07-27 |
1996-12-10 |
Minnesota Mining And Manufacturing Company |
Adhesive sealant composition
|
|
USRE38827E1
(en)
|
1994-07-27 |
2005-10-11 |
3M Innovative Properties Company |
Adhesive sealant composition
|
|
GB9425138D0
(en)
|
1994-12-12 |
1995-02-08 |
Dynal As |
Isolation of nucleic acid
|
|
US5932462A
(en)
*
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
TW517067B
(en)
*
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
|
KR19990029749A
(ko)
*
|
1997-09-17 |
1999-04-26 |
미우라 아끼라 |
2가 반응성 수용성 고분자 유도체 및 이들을 함유하는 복합체
|
|
CN1276730A
(zh)
*
|
1997-09-18 |
2000-12-13 |
霍夫曼-拉罗奇有限公司 |
α－干扰素和金刚胺用于治疗慢性丙型肝炎的应用
|
|
US6251382B1
(en)
|
1998-04-17 |
2001-06-26 |
Enzon, Inc. |
Biodegradable high molecular weight polymeric linkers and their conjugates
|
|
CN1170543C
(zh)
*
|
1998-06-08 |
2004-10-13 |
弗·哈夫曼-拉罗切有限公司 |
PEG-IFN-α和三唑核苷在治疗慢性丙型肝炎中的用途
|
|
US20060188971A1
(en)
*
|
1998-08-06 |
2006-08-24 |
Duke University |
Urate oxidase
|
|
US6783965B1
(en)
|
2000-02-10 |
2004-08-31 |
Mountain View Pharmaceuticals, Inc. |
Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
|
|
EP2158923B1
(en)
|
1998-08-06 |
2013-02-27 |
Mountain View Pharmaceuticals, Inc. |
Peg-urate oxidase conjugates and use thereof
|
|
CA2337967C
(en)
|
1998-08-06 |
2011-11-01 |
Duke University |
Recombinant uricase protein
|
|
US6458953B1
(en)
*
|
1998-12-09 |
2002-10-01 |
La Jolla Pharmaceutical Company |
Valency platform molecules comprising carbamate linkages
|
|
CA2376057A1
(en)
*
|
1999-06-08 |
2000-12-14 |
La Jolla Pharmaceutical Company |
Valency platform molecules comprising aminooxy groups
|
|
US7169889B1
(en)
|
1999-06-19 |
2007-01-30 |
Biocon Limited |
Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
|
|
JO2291B1
(en)
|
1999-07-02 |
2005-09-12 |
اف . هوفمان لاروش ايه جي |
Erythropoietin derivatives
|
|
CZ299516B6
(cs)
*
|
1999-07-02 |
2008-08-20 |
F. Hoffmann-La Roche Ag |
Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
|
|
CA2383794A1
(en)
*
|
1999-09-07 |
2001-03-15 |
Conjuchem Inc. |
Methods and compositions containing succinimide or maleimide derivatives of antineoplastic agents
|
|
EP1212097B1
(en)
|
1999-09-10 |
2005-11-16 |
The Procter & Gamble Company |
Enzyme inhibitors
|
|
US6723788B1
(en)
|
1999-09-10 |
2004-04-20 |
The Procter & Gamble Company |
Enzyme inhibitors
|
|
US6713454B1
(en)
|
1999-09-13 |
2004-03-30 |
Nobex Corporation |
Prodrugs of etoposide and etoposide analogs
|
|
CA2385528C
(en)
|
1999-10-01 |
2013-12-10 |
Immunogen, Inc. |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
|
|
CA2395713C
(en)
|
2000-01-10 |
2012-04-10 |
Maxygen, Inc. |
G-csf conjugates
|
|
EP1982732A3
(en)
|
2000-02-11 |
2011-06-08 |
Bayer HealthCare LLC |
Factor VII or VIIA-like conjugates
|
|
US6756037B2
(en)
|
2000-03-31 |
2004-06-29 |
Enzon, Inc. |
Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups
|
|
US6777387B2
(en)
|
2000-03-31 |
2004-08-17 |
Enzon Pharmaceuticals, Inc. |
Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same
|
|
US6586398B1
(en)
*
|
2000-04-07 |
2003-07-01 |
Amgen, Inc. |
Chemically modified novel erythropoietin stimulating protein compositions and methods
|
|
CA2414076A1
(en)
|
2000-06-08 |
2001-12-13 |
La Jolla Pharmaceutical Company |
Multivalent platform molecules comprising high molecular weight polyethylene oxide
|
|
EP1299415A4
(en)
*
|
2000-07-12 |
2005-01-19 |
Gryphon Therapeutics Inc |
MODULATORS OF CHEMOKIN RECEPTORS, THEIR PREPARATION AND USE
|
|
KR100396983B1
(ko)
*
|
2000-07-29 |
2003-09-02 |
이강춘 |
고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질또는 펩타이드의 접합체
|
|
ATE500838T1
(de)
*
|
2000-09-08 |
2011-03-15 |
Amylin Pharmaceuticals Inc |
ßPSEUDOß-NATIVE CHEMISCHE LIGATION
|
|
US7118737B2
(en)
*
|
2000-09-08 |
2006-10-10 |
Amylin Pharmaceuticals, Inc. |
Polymer-modified synthetic proteins
|
|
ATE516820T1
(de)
*
|
2000-09-29 |
2011-08-15 |
Schering Corp |
Pegyliertes interleukin 10
|
|
AU2000202A
(en)
|
2000-10-31 |
2002-05-15 |
Pr Pharmaceuticals Inc |
Methods and compositions for enhanced delivery of bioactive molecules
|
|
AU2002225681A1
(en)
*
|
2000-11-15 |
2002-05-27 |
Globe Immune, Inc. |
Yeast-dentritic cell vaccines and uses thereof
|
|
CN1406131A
(zh)
*
|
2000-12-25 |
2003-03-26 |
株式会社资生堂 |
活化交感神经的香料组合物
|
|
US6350756B1
(en)
|
2001-01-18 |
2002-02-26 |
California Pacific Medical Center |
Camptothecin derivatives
|
|
ATE471956T1
(de)
*
|
2001-01-30 |
2010-07-15 |
Kyowa Hakko Kirin Co Ltd |
Verzweigte polyalkylenglykole
|
|
US6867183B2
(en)
|
2001-02-15 |
2005-03-15 |
Nobex Corporation |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US7060675B2
(en)
|
2001-02-15 |
2006-06-13 |
Nobex Corporation |
Methods of treating diabetes mellitus
|
|
MXPA03007392A
(es)
*
|
2001-02-20 |
2003-12-04 |
Enzon Inc |
Enlazantes polimericos ramificados terminalmente y conjugados polimericos que contienen los mismos.
|
|
PL367154A1
(en)
|
2001-02-27 |
2005-02-21 |
Maxygen Aps |
New interferon beta-like molecules
|
|
US6855720B2
(en)
|
2001-03-01 |
2005-02-15 |
California Pacific Medical Center |
Nitrogen-based camptothecin derivatives
|
|
US6403604B1
(en)
|
2001-03-01 |
2002-06-11 |
California Pacific Medical Center |
Nitrogen-based camptothecin derivatives
|
|
DE60233315D1
(de)
*
|
2001-03-23 |
2009-09-24 |
Enzon Inc |
Prodrugs von krebsmitteln mit substituierten aromatischen säuren
|
|
US20030108585A1
(en)
*
|
2001-05-04 |
2003-06-12 |
Roe R. Michael |
Polymer conjugates of insecticidal peptides or nucleic acids or insecticides and methods of use thereof
|
|
EP1392339A4
(en)
*
|
2001-05-04 |
2009-05-27 |
Univ North Carolina State |
POLYMER CONJUGATES OF INSECTICIDES, PEPTIDES OR NUCLEIC ACIDS AND METHOD OF USE THEREOF
|
|
US6828297B2
(en)
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6828305B2
(en)
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6713452B2
(en)
|
2001-06-04 |
2004-03-30 |
Nobex Corporation |
Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6858580B2
(en)
|
2001-06-04 |
2005-02-22 |
Nobex Corporation |
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US7713932B2
(en)
|
2001-06-04 |
2010-05-11 |
Biocon Limited |
Calcitonin drug-oligomer conjugates, and uses thereof
|
|
US6835802B2
(en)
|
2001-06-04 |
2004-12-28 |
Nobex Corporation |
Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
|
|
US20040077835A1
(en)
*
|
2001-07-12 |
2004-04-22 |
Robin Offord |
Chemokine receptor modulators, production and use
|
|
KR100761652B1
(ko)
*
|
2001-08-25 |
2007-10-04 |
동아제약주식회사 |
단백질 또는 펩타이드에 결합되는 다가지의 고분자유도체와 접합체
|
|
US6913903B2
(en)
*
|
2001-09-07 |
2005-07-05 |
Nobex Corporation |
Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
US7166571B2
(en)
|
2001-09-07 |
2007-01-23 |
Biocon Limited |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
US7196059B2
(en)
|
2001-09-07 |
2007-03-27 |
Biocon Limited |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US6770625B2
(en)
|
2001-09-07 |
2004-08-03 |
Nobex Corporation |
Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US7030082B2
(en)
*
|
2001-09-07 |
2006-04-18 |
Nobex Corporation |
Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
|
|
US7312192B2
(en)
*
|
2001-09-07 |
2007-12-25 |
Biocon Limited |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
US8008252B2
(en)
|
2001-10-10 |
2011-08-30 |
Novo Nordisk A/S |
Factor VII: remodeling and glycoconjugation of Factor VII
|
|
US7049285B2
(en)
*
|
2001-10-31 |
2006-05-23 |
Myung-Ok Park |
Biocompatible polymers including peptide spacer
|
|
MXPA04004336A
(es)
*
|
2001-11-07 |
2005-05-16 |
Nektar Therapeutics Al Corp |
Polimeros ramificados y sus conjugados.
|
|
DE60234858D1
(de)
*
|
2001-11-09 |
2010-02-04 |
Enzon Inc |
Polyalkylenoxid-Konjugate von thiolhaltigen Arzneistoffen
|
|
US20030171285A1
(en)
*
|
2001-11-20 |
2003-09-11 |
Finn Rory F. |
Chemically-modified human growth hormone conjugates
|
|
EP1456223B1
(en)
*
|
2001-12-19 |
2009-08-12 |
The University Of Chicago |
Rapidly maturing fluorescent proteins and methods for using the same
|
|
US8048408B2
(en)
*
|
2002-01-16 |
2011-11-01 |
Biocompatibles Uk Limited |
Polymer conjugates
|
|
CA2473376A1
(en)
|
2002-01-16 |
2003-07-31 |
Invitrogen Dynal As |
Method for isolating nucleic acids and protein from a single sample
|
|
KR100888371B1
(ko)
|
2002-01-17 |
2009-03-13 |
동아제약주식회사 |
가지 달린 고분자 유도체와 인터페론 결합체를 포함하는 항바이러스제
|
|
WO2003076490A1
(en)
*
|
2002-03-13 |
2003-09-18 |
Beijing Jiankai Technology Co., Ltd. |
Hydrophilic polymer derivate with y type branch and preparation method of it medical composite comprising above compound
|
|
WO2003079980A2
(en)
*
|
2002-03-19 |
2003-10-02 |
A & D Bioscience, Inc. |
Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
|
|
EP1490402A4
(en)
*
|
2002-03-20 |
2007-05-02 |
Biopolymed Inc |
PREPARATION OF CYSTEINREST STOCHIOMETRIC WITH BIOKOMPATIBLE POLYMER CONJUGATED G-CSF
|
|
BR0308710A
(pt)
*
|
2002-03-26 |
2007-01-09 |
Biosynexus Inc |
conjugados poliméricos antimicrobianos
|
|
US20050233949A1
(en)
*
|
2002-04-12 |
2005-10-20 |
Holick Michael F |
Conjugates comprising cancer cell specific ligands, a sugar and cancer chemotherapeutic agents/boron neutron capture therapy agents, and uses thereof
|
|
US20030215395A1
(en)
*
|
2002-05-14 |
2003-11-20 |
Lei Yu |
Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier
|
|
AU2003240790A1
(en)
*
|
2002-05-28 |
2003-12-12 |
Pharmacia Corporation |
Antibody peg positional isomers, compositions comprising same, and use thereof
|
|
WO2003101406A1
(en)
*
|
2002-06-03 |
2003-12-11 |
California Pacific Medical Center |
Homo-camptothecin derivatives
|
|
US6933302B2
(en)
*
|
2002-06-03 |
2005-08-23 |
California Pacific Medical Center |
Nitrogen-based homo-camptothecin derivatives
|
|
AU2003236521A1
(en)
|
2002-06-13 |
2003-12-31 |
Nobex Corporation |
Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
|
|
MXPA04012496A
(es)
|
2002-06-21 |
2005-09-12 |
Novo Nordisk Healthcare Ag |
Glicoformos del factor vii pegilados.
|
|
BR0311978A
(pt)
|
2002-06-21 |
2005-03-22 |
Novo Nordisk Healthcare Ag |
Preparação, método para preparar a mesma, formulação farmacêutica, métodos para tratar de uma sìndrome responsiva ao fator vii, para prevenir hemorragias indesejáveis, para prevenir coagulação sanguìnea indesejável e para prevenir as reações mediadas pelo fator tecidual, e, uso de uma preparação
|
|
US7122189B2
(en)
|
2002-08-13 |
2006-10-17 |
Enzon, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
US7413738B2
(en)
|
2002-08-13 |
2008-08-19 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on biodegradable linkers
|
|
US7087229B2
(en)
*
|
2003-05-30 |
2006-08-08 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
US20040091490A1
(en)
*
|
2002-08-28 |
2004-05-13 |
Robert Johnson |
Stable pH optimized formulation of a modified antibody
|
|
WO2004019860A2
(en)
*
|
2002-08-28 |
2004-03-11 |
Pharmacia Corporation |
Formulations of modified antibodies and methods of making the same
|
|
EP1591467A1
(en)
*
|
2002-09-09 |
2005-11-02 |
Nektar Therapeutics Al, Corporation |
Conjugate between a polyethylene glycol having a terminal alkanal group and a human growth hormone
|
|
KR100974843B1
(ko)
|
2002-09-09 |
2010-08-11 |
넥타르 테라퓨틱스 |
수용성 중합체 알카날
|
|
US7556813B2
(en)
*
|
2002-09-27 |
2009-07-07 |
Trimeris, Inc. |
Antiviral peptide-polymer conjugate comprising a polymer covalently attached to two or more synthetic HIV gp41 HR1 and/or HR2 peptides
|
|
US8129330B2
(en)
*
|
2002-09-30 |
2012-03-06 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
US20040062748A1
(en)
|
2002-09-30 |
2004-04-01 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
PA8588901A1
(es)
*
|
2002-11-20 |
2005-02-04 |
Pharmacia Corp |
Conjugados de hormona de crecimiento humana pegilados n-terminales y proceso para su preparacion
|
|
GB0229287D0
(en)
*
|
2002-12-16 |
2003-01-22 |
Dna Res Innovations Ltd |
Polyfunctional reagents
|
|
AU2003303636B2
(en)
*
|
2002-12-26 |
2010-08-05 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
|
|
CN102319437B
(zh)
*
|
2002-12-26 |
2017-10-13 |
山景医药公司 |
具有增强的生物学效用的干扰素‑β的聚合物缀合物
|
|
WO2004061094A1
(en)
|
2002-12-30 |
2004-07-22 |
Gryphon Therapeutics, Inc. |
Water-soluble thioester and selenoester compounds and methods for making and using the same
|
|
US20050221443A1
(en)
*
|
2003-01-06 |
2005-10-06 |
Xencor, Inc. |
Tumor necrosis factor super family agonists
|
|
US20050130892A1
(en)
*
|
2003-03-07 |
2005-06-16 |
Xencor, Inc. |
BAFF variants and methods thereof
|
|
US20060014248A1
(en)
*
|
2003-01-06 |
2006-01-19 |
Xencor, Inc. |
TNF super family members with altered immunogenicity
|
|
US7553930B2
(en)
*
|
2003-01-06 |
2009-06-30 |
Xencor, Inc. |
BAFF variants and methods thereof
|
|
US20040138154A1
(en)
*
|
2003-01-13 |
2004-07-15 |
Lei Yu |
Solid surface for biomolecule delivery and high-throughput assay
|
|
US20070269891A9
(en)
*
|
2003-01-13 |
2007-11-22 |
Yasunobu Tanaka |
Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells
|
|
GB0301014D0
(en)
*
|
2003-01-16 |
2003-02-19 |
Biocompatibles Ltd |
Conjugation reactions
|
|
US7871607B2
(en)
*
|
2003-03-05 |
2011-01-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
|
|
US20090123367A1
(en)
*
|
2003-03-05 |
2009-05-14 |
Delfmems |
Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases
|
|
US7767429B2
(en)
*
|
2003-03-05 |
2010-08-03 |
Halozyme, Inc. |
Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof
|
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
|
JP2006523211A
(ja)
|
2003-03-14 |
2006-10-12 |
ネオス テクノロジーズ インコーポレイテッド |
分岐水溶性ポリマーとその複合物
|
|
US7332164B2
(en)
*
|
2003-03-21 |
2008-02-19 |
Enzon Pharmaceuticals, Inc. |
Heterobifunctional polymeric bioconjugates
|
|
US7610156B2
(en)
*
|
2003-03-31 |
2009-10-27 |
Xencor, Inc. |
Methods for rational pegylation of proteins
|
|
EP1610825A2
(en)
*
|
2003-03-31 |
2006-01-04 |
Xencor, Inc. |
Methods for rational pegylation of proteins
|
|
US7642340B2
(en)
|
2003-03-31 |
2010-01-05 |
Xencor, Inc. |
PEGylated TNF-α variant proteins
|
|
NZ542586A
(en)
|
2003-04-09 |
2009-11-27 |
Biogenerix Ag |
Method of forming a covalent conjugate between a G-CSF peptide and PEG
|
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
BRPI0409322B8
(pt)
|
2003-04-11 |
2021-05-25 |
Antriabio Inc |
método para preparar um conjugado de insulina-polímero
|
|
TW200510454A
(en)
|
2003-04-15 |
2005-03-16 |
Smithkline Beecham Corp |
Conjugates comprising human IL-18 and substitution mutants thereof
|
|
US7189694B2
(en)
*
|
2003-04-18 |
2007-03-13 |
University Of Florida Research Foundation, Inc. |
Inhibitors of autophosphorylation protein kinases
|
|
AU2004240553A1
(en)
|
2003-05-09 |
2004-12-02 |
Neose Technologies, Inc. |
Compositions and methods for the preparation of human growth hormone glycosylation mutants
|
|
EP1626983B8
(en)
*
|
2003-05-12 |
2010-12-22 |
Affymax, Inc. |
Novel poly (ethylene glycol) modified erythropoietin agonists and uses thereof
|
|
ES2395413T3
(es)
*
|
2003-05-12 |
2013-02-12 |
Affymax, Inc. |
Péptidos que se unen al receptor de eritropoyetina
|
|
JP2007500218A
(ja)
*
|
2003-05-12 |
2007-01-11 |
アフィーマックス・インコーポレイテッド |
ポリ（エチレングリコール）修飾ペプチド系化合物の新規スペーサー部分
|
|
DE602004020610D1
(de)
*
|
2003-05-12 |
2009-05-28 |
Affymax Inc |
Neue, an den erythropoietinrezeptor bindende peptide
|
|
ES2725808T3
(es)
*
|
2003-05-23 |
2019-09-27 |
Nektar Therapeutics |
Derivados de PEG que contienen dos cadenas de PEG
|
|
US7947261B2
(en)
|
2003-05-23 |
2011-05-24 |
Nektar Therapeutics |
Conjugates formed from polymer derivatives having particular atom arrangements
|
|
DK1635787T3
(da)
|
2003-06-26 |
2012-03-26 |
Control Delivery Sys Inc |
Bioeroderbare lægemiddelafgivelsessystemer med forhalet frigivelse
|
|
PT1635875E
(pt)
|
2003-06-26 |
2008-12-09 |
Psivida Inc |
Sistema de libertação de um fármaco com gelificação in situ
|
|
US9005625B2
(en)
|
2003-07-25 |
2015-04-14 |
Novo Nordisk A/S |
Antibody toxin conjugates
|
|
EP1660047B1
(en)
|
2003-08-13 |
2013-11-27 |
Biocon Limited |
Micro-particle fatty acid salt solid dosage formulations for therapeutic agents
|
|
NZ592039A
(en)
*
|
2003-08-27 |
2013-03-28 |
Ophthotech Corp |
Combination therapy for the treatment of ocular neovascular disorders
|
|
CN1852740B
(zh)
|
2003-09-17 |
2011-05-11 |
耐科塔医药公司 |
多支链聚合物的药物前体
|
|
US8394365B2
(en)
|
2003-09-17 |
2013-03-12 |
Nektar Therapeutics |
Multi-arm polymer prodrugs
|
|
EP2263684A1
(en)
|
2003-10-10 |
2010-12-22 |
Novo Nordisk A/S |
IL-21 derivatives
|
|
CA2542353A1
(en)
|
2003-10-10 |
2005-04-21 |
Xencor, Inc. |
Protein based tnf-alpha variants for the treatment of tnf-alpha related disorders
|
|
ES2428358T3
(es)
|
2003-10-17 |
2013-11-07 |
Novo Nordisk A/S |
Terapia de combinación
|
|
US20050214250A1
(en)
*
|
2003-11-06 |
2005-09-29 |
Harris J M |
Method of preparing carboxylic acid functionalized polymers
|
|
US8633157B2
(en)
|
2003-11-24 |
2014-01-21 |
Novo Nordisk A/S |
Glycopegylated erythropoietin
|
|
WO2005072371A2
(en)
*
|
2004-01-26 |
2005-08-11 |
Neose Technologies, Inc. |
Branched polymeric sugars and nucleotides thereof
|
|
US7405198B2
(en)
*
|
2003-11-24 |
2008-07-29 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
US20080015142A1
(en)
*
|
2003-12-03 |
2008-01-17 |
Defrees Shawn |
Glycopegylated Follicle Stimulating Hormone
|
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
US7956032B2
(en)
|
2003-12-03 |
2011-06-07 |
Novo Nordisk A/S |
Glycopegylated granulocyte colony stimulating factor
|
|
CA2551495A1
(en)
*
|
2004-01-07 |
2005-07-28 |
Ambit Biosciences Corporation |
Conjugated small molecules
|
|
US7338933B2
(en)
|
2004-01-08 |
2008-03-04 |
Neose Technologies, Inc. |
O-linked glycosylation of peptides
|
|
US20070105770A1
(en)
*
|
2004-01-21 |
2007-05-10 |
Novo Nordisk A/S |
Transglutaminase mediated conjugation of peptides
|
|
US20050214286A1
(en)
*
|
2004-01-27 |
2005-09-29 |
University Of Southern California |
Polymer-bound antibody cancer therapeutic agent
|
|
AU2005319099B2
(en)
|
2004-02-02 |
2010-09-16 |
Ambrx, Inc. |
Modified human growth hormone
|
|
CN103755800B
(zh)
|
2004-02-02 |
2016-02-24 |
Ambrx公司 |
经修饰的人类生长激素多肽与其用途
|
|
US7803931B2
(en)
|
2004-02-12 |
2010-09-28 |
Archemix Corp. |
Aptamer therapeutics useful in the treatment of complement-related disorders
|
|
EP1734988A4
(en)
*
|
2004-03-01 |
2009-08-05 |
Enzon Pharmaceuticals Inc |
INTERFERON BETA-polymer
|
|
WO2005107815A2
(en)
*
|
2004-05-03 |
2005-11-17 |
Nektar Therapeutics Al, Corporation |
Polymer derivatives comprising an imide branching point
|
|
CN102532321B
(zh)
|
2004-06-18 |
2018-10-12 |
Ambrx公司 |
新颖抗原结合多肽和其用途
|
|
CA2571292C
(en)
|
2004-06-30 |
2013-05-21 |
Nektar Therapeutics Al, Corporation |
Polymer-factor ix moiety conjugates
|
|
AU2014280936B2
(en)
*
|
2004-06-30 |
2016-12-15 |
Nektar Therapeutics |
Polymer-factor ix moiety conjugates
|
|
WO2006010143A2
(en)
|
2004-07-13 |
2006-01-26 |
Neose Technologies, Inc. |
Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
|
|
CN103223160B
(zh)
|
2004-07-19 |
2015-02-18 |
比奥孔有限公司 |
胰岛素-低聚物共轭物,制剂及其用途
|
|
US7638299B2
(en)
|
2004-07-21 |
2009-12-29 |
Ambrx, Inc. |
Biosynthetic polypeptides utilizing non-naturally encoded amino acids
|
|
US7618615B2
(en)
|
2004-08-13 |
2009-11-17 |
Healthpartners Research Foundation |
Methods for providing neuroprotection for the animal central nervous system against neurodegeneration caused by ischemia
|
|
US9216161B2
(en)
|
2004-08-13 |
2015-12-22 |
Healthpartners Research Foundation |
Methods of treating Huntington's disease comprising administering metal chelators to the upper one-third of the nasal cavity
|
|
EP1799249A2
(en)
|
2004-09-10 |
2007-06-27 |
Neose Technologies, Inc. |
Glycopegylated interferon alpha
|
|
US7358223B2
(en)
*
|
2004-10-04 |
2008-04-15 |
Nitto Denko Corporation |
Biodegradable cationic polymers
|
|
EP3061461A1
(en)
|
2004-10-29 |
2016-08-31 |
ratiopharm GmbH |
Remodeling and glycopegylation of fibroblast growth factor (fgf)
|
|
WO2006060148A2
(en)
*
|
2004-11-11 |
2006-06-08 |
Affymax, Inc. |
Novel peptides that bind to the erythropoietin receptor
|
|
WO2006062685A2
(en)
*
|
2004-11-11 |
2006-06-15 |
Affymax, Inc. |
Novel peptides that bind to the erythropoietin receptor
|
|
AU2005323106B2
(en)
|
2004-12-22 |
2010-07-29 |
Ambrx, Inc. |
Methods for expression and purification of recombinant human growth hormone
|
|
KR101224781B1
(ko)
|
2004-12-22 |
2013-01-21 |
암브룩스, 인코포레이티드 |
비천연적으로 코딩된 아미노산을 포함하는 인간 성장호르몬의 조제물
|
|
NZ555425A
(en)
|
2004-12-22 |
2010-04-30 |
Ambrx Inc |
Compositions of aminoacyl-tRNA synthetase and uses thereof
|
|
BRPI0519562A2
(pt)
|
2004-12-27 |
2009-01-27 |
Baxter Int |
construÇço proteinÁcea, complexo, mÉtodo para prolongar a meia-vida in vivo de fator viii (fviii) ou um derivado biologicamente ativo do mesmo composiÇço farmacÊutica, e, mÉtodo para formar uma construÇço proteinÁcea
|
|
US9029331B2
(en)
|
2005-01-10 |
2015-05-12 |
Novo Nordisk A/S |
Glycopegylated granulocyte colony stimulating factor
|
|
US7365127B2
(en)
|
2005-02-04 |
2008-04-29 |
Enzon Pharmaceuticals, Inc. |
Process for the preparation of polymer conjugates
|
|
US20080268013A1
(en)
*
|
2005-02-10 |
2008-10-30 |
Emory University |
Polyethylene Oxide Polymers Including Anti-Inflammatory Glycodendrons
|
|
WO2006102659A2
(en)
*
|
2005-03-23 |
2006-09-28 |
Nektar Therapeutics Al, Corporation |
CONJUGATES OF AN hGH MOIETY AND A POLYMER
|
|
EP2314320A2
(en)
|
2005-04-05 |
2011-04-27 |
Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. |
Method for shielding functional sites or epitopes on proteins
|
|
EP1871795A4
(en)
|
2005-04-08 |
2010-03-31 |
Biogenerix Ag |
COMPOSITIONS AND METHOD FOR PRODUCING GLYCOSYLATION MUTANTS OF A PROTEASE-RESISTANT HUMAN GROWTH HORMONE
|
|
WO2008051178A2
(en)
*
|
2006-04-12 |
2008-05-02 |
Savient Pharmaceuticals, Inc. |
Purification of proteins with cationic surfactant
|
|
US8148123B2
(en)
*
|
2005-04-11 |
2012-04-03 |
Savient Pharmaceuticals, Inc. |
Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
|
|
US20080159976A1
(en)
*
|
2005-04-11 |
2008-07-03 |
Jacob Hartman |
Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
|
|
DK3321359T3
(da)
|
2005-04-11 |
2021-03-08 |
Horizon Pharma Rheumatology Llc |
Variante former af uratoxidase og anvendelse deraf
|
|
CN102807973A
(zh)
|
2005-04-11 |
2012-12-05 |
萨文特医药公司 |
尿酸氧化酶的变体形式及其用途
|
|
US7833979B2
(en)
*
|
2005-04-22 |
2010-11-16 |
Amgen Inc. |
Toxin peptide therapeutic agents
|
|
JP2008545665A
(ja)
*
|
2005-05-23 |
2008-12-18 |
ユニベルシテ ドゥ ジュネーブ |
高体温による処置のための注入可能な超常磁性ナノ粒子および高体温インプラントを形成するための使用
|
|
WO2006127910A2
(en)
|
2005-05-25 |
2006-11-30 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin formulations
|
|
US8324159B2
(en)
*
|
2005-06-03 |
2012-12-04 |
Affymax, Inc. |
Erythropoietin receptor peptide formulations and uses
|
|
US7919461B2
(en)
|
2005-06-03 |
2011-04-05 |
Affymax, Inc. |
Erythropoietin receptor peptide formulations and uses
|
|
US7550433B2
(en)
*
|
2005-06-03 |
2009-06-23 |
Affymax, Inc. |
Erythropoietin receptor peptide formulations and uses
|
|
WO2006133088A2
(en)
|
2005-06-03 |
2006-12-14 |
Ambrx, Inc. |
Improved human interferon molecules and their uses
|
|
CA2611836A1
(en)
*
|
2005-06-13 |
2006-12-21 |
Nastech Pharmaceutical Company Inc. |
Transmucosal delivery of peptide derivatives
|
|
WO2006134173A2
(en)
|
2005-06-17 |
2006-12-21 |
Novo Nordisk Health Care Ag |
Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine
|
|
US7695710B2
(en)
*
|
2005-06-20 |
2010-04-13 |
Pepgen Corporation |
Antitumor and antiviral combination therapies using low-toxicity, long-circulating human interferon-alpha analogs
|
|
CN101257925A
(zh)
*
|
2005-06-20 |
2008-09-03 |
派普根公司 |
人干扰素α类似物和干扰素τ的低毒长循环的嵌合体
|
|
US8568705B2
(en)
|
2005-07-18 |
2013-10-29 |
Nektar Therapeutics |
Method for preparing branched functionalized polymers using branched polyol cores
|
|
KR100735784B1
(ko)
*
|
2005-07-20 |
2007-07-06 |
재단법인 목암생명공학연구소 |
인간 과립구콜로니자극인자 변이체 및 이의 화학적 접합물
|
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
CA2618878C
(en)
|
2005-08-18 |
2016-06-28 |
Ambrx, Inc. |
Compositions of trna and uses thereof
|
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
|
JP4808453B2
(ja)
*
|
2005-08-26 |
2011-11-02 |
株式会社荏原製作所 |
研磨方法及び研磨装置
|
|
CN101268098A
(zh)
*
|
2005-08-30 |
2008-09-17 |
诺沃-诺迪斯克保健股份有限公司 |
聚乙二醇化生长激素的液体制剂
|
|
US7875602B2
(en)
*
|
2005-10-21 |
2011-01-25 |
Sutter West Bay Hospitals |
Camptothecin derivatives as chemoradiosensitizing agents
|
|
WO2007056191A2
(en)
|
2005-11-03 |
2007-05-18 |
Neose Technologies, Inc. |
Nucleotide sugar purification using membranes
|
|
EP1951890A4
(en)
|
2005-11-16 |
2009-06-24 |
Ambrx Inc |
PROCESSES AND COMPOSITIONS WITH NON-NATURAL AMINO ACIDS
|
|
US7811555B2
(en)
*
|
2005-12-30 |
2010-10-12 |
Cordis Corporation |
Tri-branched biologically active copolymer
|
|
US8133707B2
(en)
*
|
2006-01-17 |
2012-03-13 |
Enzon Pharmaceuticals, Inc. |
Methods of preparing activated polymers having alpha nitrogen groups
|
|
AU2007207618B2
(en)
*
|
2006-01-18 |
2011-03-24 |
Foresee Pharmaceuticals Co., Ltd. |
Pharmaceutical compositions with enhanced stability
|
|
US9458444B2
(en)
|
2006-02-03 |
2016-10-04 |
Opko Biologics Ltd. |
Long-acting coagulation factors and methods of producing same
|
|
US9249407B2
(en)
|
2006-02-03 |
2016-02-02 |
Opko Biologics Ltd. |
Long-acting coagulation factors and methods of producing same
|
|
US20140113860A1
(en)
|
2006-02-03 |
2014-04-24 |
Prolor Biotech Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
|
US8048849B2
(en)
|
2006-02-03 |
2011-11-01 |
Modigene, Inc. |
Long-acting polypeptides and methods of producing same
|
|
US8946155B2
(en)
|
2006-02-03 |
2015-02-03 |
Opko Biologics Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
|
US10351615B2
(en)
|
2006-02-03 |
2019-07-16 |
Opko Biologics Ltd. |
Methods of treatment with long-acting growth hormone
|
|
US10221228B2
(en)
|
2006-02-03 |
2019-03-05 |
Opko Biologics Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
|
US20150038413A1
(en)
|
2006-02-03 |
2015-02-05 |
Opko Biologics Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
|
US7671067B2
(en)
|
2006-02-09 |
2010-03-02 |
Enzon Pharmaceuticals, Inc. |
Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
|
|
US7462627B2
(en)
|
2006-02-09 |
2008-12-09 |
Enzon Pharmaceuticals, Inc. |
Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
|
|
KR20090042755A
(ko)
*
|
2006-02-28 |
2009-04-30 |
닥터 레디즈 레버러토리즈 (이유) 리미티드 |
폴리에틸렌 글리콜 카보네이트의 제조방법
|
|
EP2596807B1
(en)
|
2006-03-08 |
2015-12-16 |
Archemix LLC |
Complement binding aptamers and anti-C5 agents useful in the treatment of ocular disorders
|
|
KR20080108147A
(ko)
|
2006-03-31 |
2008-12-11 |
백스터 인터내셔널 인코포레이티드 |
페질화된 인자 ｖｉｉｉ
|
|
US7645860B2
(en)
|
2006-03-31 |
2010-01-12 |
Baxter Healthcare S.A. |
Factor VIII polymer conjugates
|
|
US7700541B2
(en)
*
|
2006-04-06 |
2010-04-20 |
Nitto Denko Corporation |
Biodegradable cationic polymers
|
|
EP2581450B1
(en)
|
2006-05-02 |
2018-08-15 |
MedImmune Limited |
Non-natural amino acid substituted polypeptides
|
|
US20080096819A1
(en)
*
|
2006-05-02 |
2008-04-24 |
Allozyne, Inc. |
Amino acid substituted molecules
|
|
US20090252720A1
(en)
|
2006-05-24 |
2009-10-08 |
Novo Nordisk Health Care Ag |
Prolonged FIX Analogues and Derivatives
|
|
CA2652256A1
(en)
*
|
2006-06-09 |
2007-12-21 |
Enzon Pharmaceuticals, Inc. |
Indenoisoquinoline-releasable polymer conjugates
|
|
NZ572519A
(en)
*
|
2006-06-30 |
2011-06-30 |
Defiante Farmaceutica Sa |
Recombinant host for producing l-asparaginase ii
|
|
WO2008003750A2
(en)
|
2006-07-07 |
2008-01-10 |
Novo Nordisk Health Care Ag |
New protein conjugates and methods for their preparation
|
|
US20080242607A1
(en)
|
2006-07-21 |
2008-10-02 |
Neose Technologies, Inc. |
Glycosylation of peptides via o-linked glycosylation sequences
|
|
ES2457527T3
(es)
|
2006-09-08 |
2014-04-28 |
Ambrx, Inc. |
ARNt Supresor hibrido en células de vertebrados
|
|
PT2064333E
(pt)
|
2006-09-08 |
2014-06-09 |
Ambrx Inc |
Supressor híbrido arnt para células de vertebrados
|
|
WO2008030558A2
(en)
|
2006-09-08 |
2008-03-13 |
Ambrx, Inc. |
Modified human plasma polypeptide or fc scaffolds and their uses
|
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
|
NZ597098A
(en)
|
2006-09-28 |
2013-05-31 |
Merck Sharp & Dohme |
Use of pegylated il-10 to treat cancer
|
|
US8969532B2
(en)
|
2006-10-03 |
2015-03-03 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
|
|
BRPI0717505B8
(pt)
|
2006-10-04 |
2021-05-25 |
Novo Nordisk As |
conjugado de peptídeo e formulação farmacêutica
|
|
WO2008051383A2
(en)
*
|
2006-10-19 |
2008-05-02 |
Amgen Inc. |
Use of alcohol co-solvents to improve pegylation reaction yields
|
|
AR063384A1
(es)
|
2006-10-25 |
2009-01-28 |
Amgen Inc |
Agentes terapeuticos a base de peptidos derivados de toxinas
|
|
JP5541594B2
(ja)
*
|
2006-11-07 |
2014-07-09 |
ディーエスエム アイピー アセッツ ビー．ブイ． |
生体分子部分を含むカルバメート、チオカルバメートまたはカルバミド
|
|
CN102827284B
(zh)
*
|
2006-11-14 |
2015-07-29 |
上海仁会生物制药股份有限公司 |
带有聚乙二醇基团的Exendin或其类似物及其制剂和用途
|
|
WO2008066902A2
(en)
|
2006-11-30 |
2008-06-05 |
Nektar Therapeutics Al, Corporation |
Method for preparing a polymer conjugate
|
|
MX2009007145A
(es)
|
2006-12-27 |
2009-08-27 |
Nektar Therapeutics Al Corp |
Conjugados de polimero con factor viii y factor de von willebrand que tienen una ligadura liberable.
|
|
NZ577397A
(en)
*
|
2006-12-27 |
2012-01-12 |
Nektar Therapeutics |
Factor ix moiety-polymer conjugates having a releasable linkage
|
|
US20080159964A1
(en)
*
|
2006-12-29 |
2008-07-03 |
Enzon Pharmaceuticals, Inc. |
Use of adenosine deaminase for treating pulmonary disease
|
|
JP2010515762A
(ja)
|
2007-01-16 |
2010-05-13 |
エンゾン ファーマスーティカルズ インコーポレイテッド |
ポサコナゾール−ポリマー複合体、並びに、ポサコナゾールおよびそのポリマー複合体を使用した治療方法
|
|
CA2676820A1
(en)
*
|
2007-01-31 |
2008-08-07 |
Affymax, Inc. |
Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules
|
|
WO2008095182A2
(en)
*
|
2007-02-01 |
2008-08-07 |
National Research Council Of Canada |
Formulations of lipophilic bioactive molecules
|
|
KR20090108082A
(ko)
|
2007-02-09 |
2009-10-14 |
엔존 파마슈티컬즈, 인코포레이티드 |
7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법
|
|
KR101476472B1
(ko)
|
2007-03-30 |
2015-01-05 |
암브룩스, 인코포레이티드 |
변형된 ｆｇｆ-21 폴리펩티드 및 그 용도
|
|
CN101796063B
(zh)
|
2007-04-03 |
2017-03-22 |
拉蒂奥法姆有限责任公司 |
使用糖聚乙二醇化g‑csf的治疗方法
|
|
US8071741B2
(en)
*
|
2007-04-20 |
2011-12-06 |
Defiante Farmaceutica, S.A. |
Stable recombinant adenosine deaminase
|
|
KR101540296B1
(ko)
*
|
2007-04-20 |
2015-07-31 |
시그마-타우 레어 디지즈 리미티드 |
효소적 항암 요법
|
|
KR20100019467A
(ko)
|
2007-05-02 |
2010-02-18 |
암브룩스, 인코포레이티드 |
변형된 인터페론 베타 폴리펩티드 및 그의 용도
|
|
EP2738257A1
(en)
|
2007-05-22 |
2014-06-04 |
Amgen Inc. |
Compositions and methods for producing bioactive fusion proteins
|
|
US20080312174A1
(en)
*
|
2007-06-05 |
2008-12-18 |
Nitto Denko Corporation |
Water soluble crosslinked polymers
|
|
US9707274B2
(en)
|
2007-06-08 |
2017-07-18 |
Healthpartners Research & Education |
Methods for preventing and treating post-traumatic stress disorder (PTSD)
|
|
US9493499B2
(en)
|
2007-06-12 |
2016-11-15 |
Novo Nordisk A/S |
Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography
|
|
EP2175878A4
(en)
*
|
2007-07-11 |
2014-12-03 |
Belrose Pharma Inc |
POLYMER DRUG DISPENSING SYSTEM WITH A MULTIPLE SUBSTITUTED AROMATIC PART
|
|
CL2008002399A1
(es)
*
|
2007-08-16 |
2009-01-02 |
Pharmaessentia Corp |
Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c.
|
|
CA2707840A1
(en)
*
|
2007-08-20 |
2009-02-26 |
Allozyne, Inc. |
Amino acid substituted molecules
|
|
US8207112B2
(en)
|
2007-08-29 |
2012-06-26 |
Biogenerix Ag |
Liquid formulation of G-CSF conjugate
|
|
US9241908B2
(en)
|
2007-10-16 |
2016-01-26 |
Biocon Limited |
Orally administrable solid pharmaceutical composition and a process thereof
|
|
ES2632504T3
(es)
|
2007-11-20 |
2017-09-13 |
Ambrx, Inc. |
Polipéptidos de insulina modificados y sus usos
|
|
NZ602170A
(en)
|
2008-02-08 |
2014-03-28 |
Ambrx Inc |
Modified leptin polypeptides and their uses
|
|
TWI395593B
(zh)
|
2008-03-06 |
2013-05-11 |
Halozyme Inc |
可活化的基質降解酵素之活體內暫時性控制
|
|
EP2662090A1
(en)
|
2008-04-14 |
2013-11-13 |
Halozyme, Inc. |
Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions
|
|
TWI394580B
(zh)
|
2008-04-28 |
2013-05-01 |
Halozyme Inc |
超快起作用胰島素組成物
|
|
US8476404B1
(en)
*
|
2008-07-04 |
2013-07-02 |
Bhalchandra Shripad Lele |
Selectively functionalized polyhydric compounds
|
|
JP5675606B2
(ja)
|
2008-07-08 |
2015-02-25 |
ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム |
シグナル伝達性転写因子（ｓｔａｔ）の増殖及び活性化の新規の抑制剤
|
|
MX2011000859A
(es)
|
2008-07-23 |
2011-02-24 |
Ambrx Inc |
Polipeptidos g-csf bovinos modificados y sus usos.
|
|
TWI421093B
(zh)
*
|
2008-07-31 |
2014-01-01 |
Pharmaessentia Corp |
胜肽－聚合物綴合物
|
|
US8637466B2
(en)
|
2008-08-11 |
2014-01-28 |
Nektar Therapeutics |
Multi-arm polymeric alkanoate conjugates
|
|
EP2157432A1
(en)
*
|
2008-08-15 |
2010-02-24 |
Qiagen GmbH |
Method for analysing a complex sample by mass spectrometry
|
|
JP2012503602A
(ja)
|
2008-09-23 |
2012-02-09 |
ネクター セラピューティックス |
対象において持続的治療薬濃度を実現するための組成物及び方法
|
|
NO2337846T3
(OSRAM)
|
2008-09-26 |
2018-06-16 |
|
|
|
PL2342223T3
(pl)
|
2008-09-26 |
2017-09-29 |
Ambrx, Inc. |
Zmodyfikowane polipeptydy zwierzęcej erytropoetyny i ich zastosowania
|
|
EA036569B1
(ru)
|
2008-12-09 |
2020-11-24 |
Галозим, Инк. |
Способ получения полипептида гиалуронидазы ph20
|
|
EP3348281B1
(en)
|
2008-12-17 |
2023-07-05 |
Merck Sharp & Dohme Corp. |
Mono- and di-peg il-10 production; and uses
|
|
CN101870728A
(zh)
|
2009-04-23 |
2010-10-27 |
派格生物医药(苏州)有限公司 |
新型Exendin变体及其缀合物
|
|
LT2440239T
(lt)
|
2009-06-09 |
2017-12-11 |
Prolong Pharmaceuticals, LLC |
Hemoglobino kompozicijos
|
|
RU2535038C2
(ru)
|
2009-06-25 |
2014-12-10 |
Криэлта Фармасьютикалз ЭлЭлСи |
Способы и наборы для прогнозирования риска инфузионных реакций и опосредованной антителами потери ответа при терапии пэгилированной уриказой с помощью мониторинга содержания мочевой кислоты в сыворотке крови
|
|
WO2011003633A1
(en)
|
2009-07-06 |
2011-01-13 |
Alize Pharma Ii |
Pegylated l-asparaginase
|
|
US9663778B2
(en)
|
2009-07-09 |
2017-05-30 |
OPKO Biologies Ltd. |
Long-acting coagulation factors and methods of producing same
|
|
US12203113B2
(en)
|
2009-07-09 |
2025-01-21 |
Opko Biologics Ltd. |
Long-acting coagulation factors and methods of producing same
|
|
AU2010280688A1
(en)
|
2009-08-05 |
2012-02-23 |
Allergan, Inc. |
Controlled release formulations of lipocalin muteins
|
|
CN102655853B
(zh)
|
2009-09-17 |
2015-07-29 |
巴克斯特卫生保健有限公司 |
透明质酸酶和免疫球蛋白的稳定的复合制剂及其使用方法
|
|
US20110081398A1
(en)
*
|
2009-10-01 |
2011-04-07 |
Tyco Healthcare Group Lp |
Multi-mechanism surgical compositions
|
|
US8968785B2
(en)
*
|
2009-10-02 |
2015-03-03 |
Covidien Lp |
Surgical compositions
|
|
US20110081701A1
(en)
*
|
2009-10-02 |
2011-04-07 |
Timothy Sargeant |
Surgical compositions
|
|
NZ600361A
(en)
|
2009-12-21 |
2014-06-27 |
Ambrx Inc |
Modified bovine somatotropin polypeptides and their uses
|
|
EP2516455A4
(en)
|
2009-12-21 |
2013-05-22 |
Ambrx Inc |
MODIFIED SWINE SOMATOTROPIN POLYPEPTIDES AND THEIR USES
|
|
US9815876B2
(en)
|
2010-03-05 |
2017-11-14 |
Omeros Corporation |
Chimeric inhibitor molecules of complement activation
|
|
US20120135912A1
(en)
|
2010-05-10 |
2012-05-31 |
Perseid Therapeutics Llc |
Polypeptide inhibitors of vla4
|
|
CA2840431A1
(en)
*
|
2010-06-24 |
2011-12-29 |
Vasculogics, Inc. |
Compositions and methods for treatment of thrombosis and for prolonging survival of stored platelets
|
|
JP5825507B2
(ja)
*
|
2010-06-25 |
2015-12-02 |
日油株式会社 |
分岐型ヘテロポリエチレングリコール
|
|
US10040761B2
(en)
*
|
2010-06-25 |
2018-08-07 |
Nof Corporation |
Branched hetero polyethylene glycol and intermediate
|
|
MX348420B
(es)
|
2010-07-20 |
2017-06-12 |
Halozyme Inc |
Efectos secundarios adversos asociados con la administracion de agentes anti-hialuronano y metodos para mejorar o prevenir los efectos secundarios.
|
|
SMT201900495T1
(it)
|
2010-08-17 |
2019-11-13 |
Ambrx Inc |
Polipeptidi di relaxina modificati e loro usi
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
TWI480288B
(zh)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
牛顆粒細胞群落刺激因子及其變體之調配物
|
|
US10894087B2
(en)
|
2010-12-22 |
2021-01-19 |
Nektar Therapeutics |
Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
|
|
US20130331443A1
(en)
|
2010-12-22 |
2013-12-12 |
Nektar Therapeutics |
Multi-arm polymeric prodrug conjugates of taxane-based compounds
|
|
IT1403458B1
(it)
|
2010-12-28 |
2013-10-17 |
Scarpa Calzaturificio Spa |
Scarpone da sci
|
|
ES2634669T3
(es)
|
2011-02-08 |
2017-09-28 |
Halozyme, Inc. |
Composición y formulación lipídica de una enzima de degradación de hialuronano y uso de la misma para el tratamiento de la hiperplasia benigna de próstata
|
|
US9340590B2
(en)
|
2011-03-16 |
2016-05-17 |
Amgen Inc. |
Potent and selective inhibitors of NaV1.3 and NaV1.7
|
|
US10166295B2
(en)
|
2011-06-02 |
2019-01-01 |
Opko Biologics Ltd. |
Pegylated OXM variants
|
|
MX341448B
(es)
|
2011-06-17 |
2016-08-19 |
Halozyme Inc |
Metodos de infusion de insulina subcutanea continua con una enzima que degrada a hialuronano.
|
|
US9993529B2
(en)
|
2011-06-17 |
2018-06-12 |
Halozyme, Inc. |
Stable formulations of a hyaluronan-degrading enzyme
|
|
JP5252036B2
(ja)
*
|
2011-06-28 |
2013-07-31 |
大日本印刷株式会社 |
親水性層を有する基材
|
|
WO2013003593A1
(en)
|
2011-06-28 |
2013-01-03 |
Alternative Innovative Technologies Llc |
Methods of use of hsp70 for increased performance or hsp70 related disorders
|
|
US9382305B2
(en)
|
2011-07-01 |
2016-07-05 |
Bayer Intellectual Property Gmbh |
Relaxin fusion polypeptides and uses thereof
|
|
PT2717917T
(pt)
|
2011-07-05 |
2016-07-27 |
Bioasis Technologies Inc |
Conjugados de anticorpos p97
|
|
US9034318B2
(en)
|
2011-08-30 |
2015-05-19 |
The Regents Of The University Of Colorado, A Body Corporate |
Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria
|
|
WO2013040501A1
(en)
|
2011-09-16 |
2013-03-21 |
Pharmathene, Inc. |
Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and uses thereof
|
|
WO2013056197A1
(en)
|
2011-10-14 |
2013-04-18 |
Alternative Innovative Technologies Llc |
Degradation resistant hsp70 formulations and uses thereof
|
|
AU2012328880B2
(en)
|
2011-10-24 |
2017-02-23 |
Halozyme, Inc. |
Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof
|
|
WO2013101509A2
(en)
|
2011-12-15 |
2013-07-04 |
Alternative Innovative Technologies Llc |
Hsp70 fusion protein conjugates and uses thereof
|
|
WO2013102144A2
(en)
|
2011-12-30 |
2013-07-04 |
Halozyme, Inc. |
Ph20 polypeptede variants, formulations and uses thereof
|
|
NZ700073A
(en)
|
2012-04-04 |
2016-08-26 |
Halozyme Inc |
Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane
|
|
US9522945B2
(en)
|
2012-04-19 |
2016-12-20 |
Opko Biologics Ltd. |
Long-acting oxyntomodulin variants and methods of producing same
|
|
PE20150181A1
(es)
|
2012-06-04 |
2015-02-28 |
Opko Biolog Ltd |
Variantes de oxm pegilada
|
|
JP6498600B2
(ja)
|
2012-06-08 |
2019-04-10 |
ストロ バイオファーマ インコーポレーテッド |
部位特異的な非天然アミノ酸残基を含む抗体、その調製方法、及びその使用方法
|
|
EP2863955B1
(en)
|
2012-06-26 |
2016-11-23 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
|
US9932565B2
(en)
|
2012-07-31 |
2018-04-03 |
Bioasis Technologies, Inc. |
Dephosphorylated lysosomal storage disease proteins and methods of use thereof
|
|
DK2890402T3
(da)
|
2012-08-31 |
2019-07-15 |
Sutro Biopharma Inc |
Modificerede aminosyrer omfattende en azidogruppe
|
|
US9278124B2
(en)
|
2012-10-16 |
2016-03-08 |
Halozyme, Inc. |
Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
|
|
WO2014074218A1
(en)
|
2012-11-12 |
2014-05-15 |
Redwood Bioscience, Inc. |
Compounds and methods for producing a conjugate
|
|
US9310374B2
(en)
|
2012-11-16 |
2016-04-12 |
Redwood Bioscience, Inc. |
Hydrazinyl-indole compounds and methods for producing a conjugate
|
|
EP2920148B1
(en)
|
2012-11-16 |
2019-06-12 |
The Regents of the University of California |
Pictet-spengler ligation for protein chemical modification
|
|
SG10202010383YA
(en)
|
2012-11-20 |
2020-11-27 |
Opko Biologics Ltd |
Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides
|
|
JP6426107B2
(ja)
|
2012-12-20 |
2018-11-21 |
アムジエン・インコーポレーテツド |
Ａｐｊ受容体アゴニストおよびその使用
|
|
WO2014110867A1
(zh)
*
|
2013-01-17 |
2014-07-24 |
厦门赛诺邦格生物科技有限公司 |
一种单一官能化的支化聚乙二醇及其修饰的生物相关物质
|
|
WO2014114262A1
(zh)
*
|
2013-01-28 |
2014-07-31 |
天津键凯科技有限公司 |
水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途
|
|
US9700633B2
(en)
|
2013-01-28 |
2017-07-11 |
Jenkem Technology Co., Ltd., Tianjin Branch |
Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
|
|
US9675678B2
(en)
|
2013-01-29 |
2017-06-13 |
The Regents Of The University Of Colorado, A Body Corporate |
Compositions and methods for treatment of homocystinuria
|
|
US10279012B2
(en)
|
2013-03-11 |
2019-05-07 |
Healthpartners Research & Education |
Methods of treating and preventing social communication disorder in patients by intranasal administration of insulin
|
|
WO2014165277A2
(en)
|
2013-03-12 |
2014-10-09 |
Amgen Inc. |
POTENT AND SELECTIVE INHIBITORS OF Nav1.7
|
|
EP2970433B1
(en)
|
2013-03-13 |
2019-09-18 |
Bioasis Technologies Inc. |
Fragments of p97 and uses thereof
|
|
CN105209054A
(zh)
|
2013-04-18 |
2015-12-30 |
阿尔莫生物科技股份有限公司 |
使用白细胞介素-10治疗疾病和病症的方法
|
|
US10392611B2
(en)
|
2013-05-30 |
2019-08-27 |
Duke University |
Polymer conjugates having reduced antigenicity and methods of using the same
|
|
US10364451B2
(en)
|
2013-05-30 |
2019-07-30 |
Duke University |
Polymer conjugates having reduced antigenicity and methods of using the same
|
|
JP2016528879A
(ja)
|
2013-06-17 |
2016-09-23 |
アルモ・バイオサイエンシーズ・インコーポレイテッド |
タンパク質の同一性および安定性を評価する方法
|
|
TW201534726A
(zh)
|
2013-07-03 |
2015-09-16 |
Halozyme Inc |
熱穩定ｐｈ２０玻尿酸酶變異體及其用途
|
|
WO2015006555A2
(en)
|
2013-07-10 |
2015-01-15 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
KR102948178B1
(ko)
|
2013-07-12 |
2026-04-10 |
아스텔라스 유에스 엘엘씨 |
안과적 질환을 치료하거나 예방하기 위한 방법
|
|
EP3038657A2
(en)
|
2013-08-28 |
2016-07-06 |
Bioasis Technologies Inc. |
Cns-targeted conjugates having modified fc regions and methods of use thereof
|
|
HK1226308A1
(zh)
|
2013-08-30 |
2017-09-29 |
Armo Biosciences, Inc. |
使用白细胞介素-10治疗疾病和病症的方法
|
|
US9840493B2
(en)
|
2013-10-11 |
2017-12-12 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
AU2014337555C1
(en)
|
2013-10-15 |
2021-01-28 |
Seagen Inc. |
PEGylated drug-linkers for improved Ligand-Drug Conjugate pharmacokinetics
|
|
US20150158926A1
(en)
|
2013-10-21 |
2015-06-11 |
Opko Biologics, Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
|
US11413332B2
(en)
|
2013-11-11 |
2022-08-16 |
Armo Biosciences, Inc. |
Methods of using interleukin-10 for treating diseases and disorders
|
|
CN105744935B
(zh)
|
2013-11-27 |
2022-09-30 |
雷德伍德生物科技股份有限公司 |
肼基-吡咯并化合物及用于生成缀合物的方法
|
|
ITTV20130204A1
(it)
|
2013-12-06 |
2015-06-07 |
Scarpa Calzaturificio Spa |
Scarpone da sci
|
|
ITTV20130205A1
(it)
|
2013-12-06 |
2015-06-07 |
Scarpa Calzaturificio Spa |
Scarpone da sci
|
|
US10314911B2
(en)
|
2014-04-08 |
2019-06-11 |
Healthpartners Research & Education |
Methods for protecting and treating traumatic brain injury, concussion and brain inflammation with intranasal insulin
|
|
US10293043B2
(en)
|
2014-06-02 |
2019-05-21 |
Armo Biosciences, Inc. |
Methods of lowering serum cholesterol
|
|
EP3155002B1
(en)
|
2014-06-10 |
2019-11-27 |
Amgen Inc. |
Apelin polypeptides
|
|
EP3186281B1
(en)
|
2014-08-28 |
2019-04-10 |
Halozyme, Inc. |
Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor
|
|
BR112017007765B1
(pt)
|
2014-10-14 |
2023-10-03 |
Halozyme, Inc |
Composições de adenosina deaminase-2 (ada2), variantes do mesmo e métodos de usar o mesmo
|
|
KR20170068553A
(ko)
|
2014-10-14 |
2017-06-19 |
아르모 바이오사이언시스 인코포레이티드 |
인터류킨-15 조성물 및 이의 용도
|
|
JP6675394B2
(ja)
|
2014-10-22 |
2020-04-01 |
アルモ・バイオサイエンシーズ・インコーポレイテッド |
疾患及び障害の治療のためにインターロイキン−１０を使用する方法
|
|
WO2016065106A1
(en)
|
2014-10-23 |
2016-04-28 |
Ngm Biopharmaceuticals, Inc. |
Pharmaceutical compositions comprising peptide variants and methods of use thereof
|
|
BR112017008157A2
(pt)
|
2014-10-24 |
2017-12-19 |
Bristol Myers Squibb Co |
polipeptídeos de fgf-21 modificados e usos dos mesmos
|
|
CA2964390A1
(en)
|
2014-11-06 |
2016-05-12 |
Pharmaessentia Corporation |
Dosage regimen for pegylated interferon
|
|
EA201791275A1
(ru)
|
2014-12-10 |
2017-12-29 |
Опко Байолоджикс Лтд. |
Способы получения ctp-модифицированных полипептидов длительного действия
|
|
US10618970B2
(en)
|
2015-02-03 |
2020-04-14 |
Armo Biosciences, Inc. |
Method of treating cancer with IL-10 and antibodies that induce ADCC
|
|
WO2016154530A1
(en)
|
2015-03-26 |
2016-09-29 |
Duke University |
Targeted therapeutic agents comprising multivalent protein-biopolymer fusions
|
|
US20160361415A1
(en)
|
2015-05-28 |
2016-12-15 |
Armo Biosciences, Inc. |
Methods of Using Interleukin-10 for Treating Diseases and Disorders
|
|
KR20180014754A
(ko)
|
2015-05-29 |
2018-02-09 |
옵코 바이오로직스 리미티드 |
페길화된 옥신토모둘린 변이체
|
|
US20190307849A1
(en)
|
2015-05-29 |
2019-10-10 |
Armo Biosciences, Inc. |
Methods of using interleukin-10 for treating diseases and disorders
|
|
ES2902467T3
(es)
|
2015-06-15 |
2022-03-28 |
Univ Leland Stanford Junior |
TIMP2 para su uso en el tratamiento de afecciones asociadas al envejecimiento
|
|
IL301728A
(en)
|
2015-06-19 |
2023-05-01 |
Opko Biologics Ltd |
Long-term coagulation factors and methods for their preparation
|
|
WO2017024182A1
(en)
|
2015-08-04 |
2017-02-09 |
Duke University |
Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
|
|
JP7053453B2
(ja)
|
2015-08-25 |
2022-04-12 |
アルモ・バイオサイエンシーズ・インコーポレイテッド |
疾患及び障害を治療するためのインターロイキン１０の使用方法
|
|
PL3998067T3
(pl)
|
2015-11-09 |
2025-01-07 |
The Regents Of The University Of Colorado, A Body Corporate |
Kompozycje do leczenia homocystynurii i sposoby jej leczenia
|
|
AU2016353988B2
(en)
|
2015-11-09 |
2019-09-26 |
Ngm Biopharmaceuticals, Inc. |
Methods for treatment of bile acid-related disorders
|
|
ES2908470T3
(es)
|
2015-11-09 |
2022-04-29 |
Scherer Technologies Llc R P |
Conjugados de anticuerpo anti-CD22-maitansina y métodos de uso de los mismos
|
|
TWI852735B
(zh)
|
2015-12-04 |
2024-08-11 |
美商思進公司 |
四級胺化妥布賴森(tubulysin)化合物之結合物
|
|
US11793880B2
(en)
|
2015-12-04 |
2023-10-24 |
Seagen Inc. |
Conjugates of quaternized tubulysin compounds
|
|
US20190015520A1
(en)
*
|
2015-12-21 |
2019-01-17 |
Duke University |
Polymer conjugates having reduced antigenicity and methods of using the same
|
|
US11752213B2
(en)
|
2015-12-21 |
2023-09-12 |
Duke University |
Surfaces having reduced non-specific binding and antigenicity
|
|
ITUB20160158A1
(it)
|
2016-01-15 |
2017-07-15 |
Scarpa Calzaturificio Spa |
Scarpone da sci
|
|
WO2017160599A1
(en)
|
2016-03-14 |
2017-09-21 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Use of cd300b antagonists to treat sepsis and septic shock
|
|
KR102626498B1
(ko)
|
2016-03-25 |
2024-01-19 |
씨젠 인크. |
페길화된 약물-링커 및 그의 중간체의 제조를 위한 공정
|
|
US10421785B2
(en)
|
2016-04-11 |
2019-09-24 |
Bar-Ilan University |
Delta receptor agonist peptides and use thereof
|
|
ES3046711T3
(en)
|
2016-04-15 |
2025-12-02 |
Beckman Coulter Inc |
Photoactive macromolecules and uses thereof
|
|
WO2017210476A1
(en)
|
2016-06-01 |
2017-12-07 |
Duke University |
Nonfouling biosensors
|
|
EP3468610A1
(en)
|
2016-06-09 |
2019-04-17 |
OPKO Biologics Ltd. |
Long-acting oxyntomodulin formulation and methods of producing and administering same
|
|
HUE064463T2
(hu)
|
2016-07-11 |
2024-03-28 |
Opko Biologics Ltd |
Hosszantartó hatású VII. koagulációs faktor és az elõállítására vonatkozó eljárások
|
|
WO2018053201A1
(en)
|
2016-09-14 |
2018-03-22 |
Duke University |
Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs
|
|
EP3515928B1
(en)
|
2016-09-23 |
2026-01-28 |
Duke University |
Unstructured non-repetitive polypeptides having lcst behavior
|
|
JP7042053B2
(ja)
|
2016-10-07 |
2022-03-25 |
国立大学法人東京工業大学 |
分岐型ヘテロ単分散ポリエチレングリコール、その製造方法、及びその結合体
|
|
WO2018085493A1
(en)
|
2016-11-04 |
2018-05-11 |
Georgia State University Research Foundation, Inc. |
Endotoxin free asparaginase
|
|
US20200237881A1
(en)
|
2019-01-30 |
2020-07-30 |
Horizon Pharma Rheumatology Llc |
Reducing immunogenicity to pegloticase
|
|
EP3538135A4
(en)
|
2016-11-11 |
2020-07-29 |
Horizon Pharma Rheumatology LLC |
POLYTHERAPIES OF PREDNISONE AND URICASE MOLECULES AND THEIR USES
|
|
AU2016429272A1
(en)
|
2016-11-14 |
2019-05-02 |
Hangzhou Dac Biotech Co., Ltd. |
Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
EP3551703A4
(en)
|
2016-12-12 |
2021-01-20 |
Becton, Dickinson and Company |
WATER-SOLUBLE POLYMERIC DYES
|
|
US11648200B2
(en)
|
2017-01-12 |
2023-05-16 |
Duke University |
Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
|
|
US10266578B2
(en)
|
2017-02-08 |
2019-04-23 |
Bristol-Myers Squibb Company |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
|
US11730822B2
(en)
|
2017-03-24 |
2023-08-22 |
Seagen Inc. |
Process for the preparation of glucuronide drug-linkers and intermediates thereof
|
|
WO2018183671A1
(en)
|
2017-03-29 |
2018-10-04 |
Tdw Group |
Protein conjugates
|
|
JP6935059B2
(ja)
|
2017-03-30 |
2021-09-15 |
日油株式会社 |
カルボキシル基を一つ有するポリエチレングリコールの精製方法
|
|
EP3612214A4
(en)
|
2017-04-17 |
2021-01-20 |
The Regents of the University of Colorado, A Body Corporate |
ENZYME REPLACEMENT THERAPY OPTIMIZATION FOR THE TREATMENT OF HOMOCYSTINURIA
|
|
WO2018213320A1
(en)
|
2017-05-15 |
2018-11-22 |
Duke University |
Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
|
|
AU2018290281B2
(en)
|
2017-06-22 |
2021-12-16 |
Vertex Pharmaceuticals Incorporated |
Modified membrane type serine protease 1 (MTSP-1) polypeptides and methods of use
|
|
EP3658168A4
(en)
|
2017-06-30 |
2021-07-14 |
Duke University |
ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULUS SENSITIVE BIOPOLYMER NETWORKS
|
|
US20200353050A1
(en)
|
2017-11-10 |
2020-11-12 |
Armo Biosciences, Inc. |
Compositions and methods of use of interleukin-10 in combination with immune check-point pathway inhibitors
|
|
WO2019133399A1
(en)
|
2017-12-26 |
2019-07-04 |
Becton, Dickinson And Company |
Deep ultraviolet-excitable water-solvated polymeric dyes
|
|
WO2019147954A1
(en)
|
2018-01-26 |
2019-08-01 |
Duke University |
Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
|
|
CN119242071A
(zh)
|
2018-03-30 |
2025-01-03 |
贝克顿·迪金森公司 |
含侧基发色团的水溶性聚合染料
|
|
WO2019211842A1
(en)
|
2018-04-30 |
2019-11-07 |
Opko Biologics Ltd. |
Long-acting human growth hormone-antagonists and methods of producing the same
|
|
EP3788343B1
(en)
|
2018-04-30 |
2024-03-27 |
Duke University |
Stimuli-responsive peg-like polymer-based drug delivery platform
|
|
US20190351031A1
(en)
|
2018-05-16 |
2019-11-21 |
Halozyme, Inc. |
Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
|
|
EP3810189A1
(en)
|
2018-06-19 |
2021-04-28 |
Armo Biosciences, Inc. |
Compositions and methods of use of il-10 agents in conjunction with chimeric antigen receptor cell therapy
|
|
US20220162336A1
(en)
|
2018-07-22 |
2022-05-26 |
Bioasis Technologies, Inc. |
Treatment of lymphatic metastases
|
|
US11649275B2
(en)
|
2018-08-02 |
2023-05-16 |
Duke University |
Dual agonist fusion proteins
|
|
WO2020051541A1
(en)
|
2018-09-07 |
2020-03-12 |
Duke University |
Nanoparticulate drug delivery systems
|
|
MX2021002575A
(es)
|
2018-09-11 |
2021-06-08 |
Ambrx Inc |
Conjugados de polipeptidos de interleucina-2 y sus usos.
|
|
CN110964116A
(zh)
|
2018-09-26 |
2020-04-07 |
北京辅仁瑞辉生物医药研究院有限公司 |
GLP1-Fc融合蛋白及其缀合物
|
|
AU2019361206A1
(en)
|
2018-10-19 |
2021-06-03 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
|
|
US12441776B2
(en)
|
2018-11-30 |
2025-10-14 |
Eirgen Pharma Ltd. |
Oxyntomodulin peptide analog formulations
|
|
US11613744B2
(en)
|
2018-12-28 |
2023-03-28 |
Vertex Pharmaceuticals Incorporated |
Modified urokinase-type plasminogen activator polypeptides and methods of use
|
|
WO2020140101A1
(en)
|
2018-12-28 |
2020-07-02 |
Catalyst Biosciences, Inc. |
Modified urokinase-type plasminogen activator polypeptides and methods of use
|
|
US12121566B2
(en)
|
2019-01-30 |
2024-10-22 |
Horizon Therapeutics Usa, Inc. |
Methods for treating gout
|
|
US20200254065A1
(en)
|
2019-02-11 |
2020-08-13 |
Opko Biologics Ltd. |
Long-acting glp-2 analogs
|
|
CN119455003A
(zh)
|
2019-02-12 |
2025-02-18 |
Ambrx公司 |
包含抗体-tlr激动剂缀合物的组合物、方法和用途
|
|
US10882954B2
(en)
|
2019-04-11 |
2021-01-05 |
Sunbio Inc. |
Tertiary alkoxy polyethylene glycol and derivatives thereof
|
|
CN112175088B
(zh)
|
2019-07-02 |
2023-03-28 |
江苏晟斯生物制药有限公司 |
改进的fix融合蛋白、缀合物及其应用
|
|
US11512314B2
(en)
|
2019-07-12 |
2022-11-29 |
Duke University |
Amphiphilic polynucleotides
|
|
EP4021479A2
(en)
|
2019-08-27 |
2022-07-06 |
Tonix Pharma Limited |
Modified tff2 polypeptides
|
|
WO2021183832A1
(en)
|
2020-03-11 |
2021-09-16 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and methods of use thereof
|
|
US20210355468A1
(en)
|
2020-05-18 |
2021-11-18 |
Bioasis Technologies, Inc. |
Compositions and methods for treating lewy body dementia
|
|
US20210393787A1
(en)
|
2020-06-17 |
2021-12-23 |
Bioasis Technologies, Inc. |
Compositions and methods for treating frontotemporal dementia
|
|
EP3954393A1
(en)
|
2020-08-13 |
2022-02-16 |
Bioasis Technologies Inc. |
Combination therapies for delivery across the blood brain barrier
|
|
AU2021327396A1
(en)
|
2020-08-20 |
2023-03-23 |
Ambrx, Inc. |
Antibody-TLR agonist conjugates, methods and uses thereof
|
|
US11952461B2
(en)
|
2021-03-22 |
2024-04-09 |
Sunbio, Inc. |
Siloxy polyethylene glycol and derivatives thereof
|
|
US20220313798A1
(en)
|
2021-03-30 |
2022-10-06 |
Jazz Pharmaceuticals Ireland Ltd. |
Dosing of recombinant l-asparaginase
|
|
MX2023011480A
(es)
|
2021-04-03 |
2023-12-06 |
Ambrx Inc |
Conjugados anticuerpo anti-her2-fármaco y usos de estos.
|
|
EP4155349A1
(en)
|
2021-09-24 |
2023-03-29 |
Becton, Dickinson and Company |
Water-soluble yellow green absorbing dyes
|
|
CN117980327A
(zh)
|
2021-11-03 |
2024-05-03 |
杭州多禧生物科技有限公司 |
抗体的特异性偶联
|
|
AU2023298234A1
(en)
|
2022-07-01 |
2025-01-16 |
Beckman Coulter, Inc. |
Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives
|
|
WO2024015529A2
(en)
|
2022-07-14 |
2024-01-18 |
Jazz Pharmaceuticals Ireland Ltd. |
Combination therapies involving l-asparaginase
|
|
WO2024044327A1
(en)
|
2022-08-26 |
2024-02-29 |
Beckman Coulter, Inc. |
Dhnt monomers and polymer dyes with modified photophysical properties
|
|
WO2024196805A1
(en)
|
2023-03-17 |
2024-09-26 |
Beckman Coulter, Inc. |
Benzothienopyrrole cyanine dyes
|
|
US12269875B2
(en)
|
2023-08-03 |
2025-04-08 |
Jeff R. Peterson |
Gout flare prevention methods using IL-1BETA blockers
|
|
CN121866309A
(zh)
|
2023-09-21 |
2026-04-14 |
贝克曼库尔特有限公司 |
用于流式细胞术的二氢菲（dhp）桥接染料
|
|
WO2025227129A2
(en)
|
2024-04-25 |
2025-10-30 |
Starrock Pharma Llc |
Delivery vehicles comprising proglucagon derived polypeptides and anabolic polypeptides and uses thereof
|
|
US20250341516A1
(en)
|
2024-05-01 |
2025-11-06 |
BioLegend, Inc. |
Compositions for use with multiple fluorophores and methods of using
|
|
WO2026043823A2
(en)
|
2024-08-19 |
2026-02-26 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of preparation and uses thereof
|