JP2000515550A - サイクリン依存キナーゼ２およびＩκＢ―αのプリン阻害剤 - Google Patents
サイクリン依存キナーゼ２およびＩκＢ―αのプリン阻害剤Info
- Publication number
- JP2000515550A JP2000515550A JP10508039A JP50803998A JP2000515550A JP 2000515550 A JP2000515550 A JP 2000515550A JP 10508039 A JP10508039 A JP 10508039A JP 50803998 A JP50803998 A JP 50803998A JP 2000515550 A JP2000515550 A JP 2000515550A
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- lower alkyl
- group
- aryl
- heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 102000018745 NF-KappaB Inhibitor alpha Human genes 0.000 title description 19
- 102000015792 Cyclin-Dependent Kinase 2 Human genes 0.000 title description 11
- 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 title description 11
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- 239000003112 inhibitor Substances 0.000 title description 8
- -1 2,6,9-trisubstituted purine Chemical class 0.000 claims abstract description 108
- 239000000203 mixture Substances 0.000 claims abstract description 69
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- 208000035269 cancer or benign tumor Diseases 0.000 claims abstract description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 101
- 125000001072 heteroaryl group Chemical group 0.000 claims description 67
- 125000000623 heterocyclic group Chemical group 0.000 claims description 53
- 125000003118 aryl group Chemical group 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 30
- 125000003107 substituted aryl group Chemical group 0.000 claims description 30
- 125000003545 alkoxy group Chemical group 0.000 claims description 28
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 26
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 22
- 125000004432 carbon atom Chemical group C* 0.000 claims description 22
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- 125000004076 pyridyl group Chemical group 0.000 claims 8
- 125000006187 phenyl benzyl group Chemical group 0.000 claims 6
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 27
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 27
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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- ARYHTUPFQTUBBG-UHFFFAOYSA-N thiophen-2-ylboronic acid Chemical compound OB(O)C1=CC=CS1 ARYHTUPFQTUBBG-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/692,012 | 1996-08-02 | ||
| US08/692,012 US5866702A (en) | 1996-08-02 | 1996-08-02 | Purine inhibitors of cyclin dependent kinase 2 |
| PCT/US1997/013386 WO1998005335A1 (en) | 1996-08-02 | 1997-08-01 | PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND IλB-$g(a) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000515550A true JP2000515550A (ja) | 2000-11-21 |
| JP2000515550A5 JP2000515550A5 (ref) | 2005-04-07 |
Family
ID=24778922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10508039A Ceased JP2000515550A (ja) | 1996-08-02 | 1997-08-01 | サイクリン依存キナーゼ２およびＩκＢ―αのプリン阻害剤 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5866702A (ref) |
| EP (1) | EP1021186B1 (ref) |
| JP (1) | JP2000515550A (ref) |
| KR (1) | KR100403336B1 (ref) |
| CN (1) | CN1161356C (ref) |
| AT (1) | ATE298572T1 (ref) |
| AU (1) | AU731778B2 (ref) |
| BR (1) | BR9710801A (ref) |
| CA (1) | CA2262454C (ref) |
| CZ (1) | CZ299381B6 (ref) |
| DE (1) | DE69733674T2 (ref) |
| DK (1) | DK1021186T3 (ref) |
| ES (1) | ES2242981T3 (ref) |
| GE (1) | GEP20022786B (ref) |
| HU (1) | HUP9902414A3 (ref) |
| IL (1) | IL128323A (ref) |
| NO (1) | NO323775B1 (ref) |
| NZ (1) | NZ334061A (ref) |
| PL (1) | PL189775B1 (ref) |
| PT (1) | PT1021186E (ref) |
| RU (1) | RU2220968C2 (ref) |
| SI (1) | SI1021186T1 (ref) |
| TR (1) | TR199900683T2 (ref) |
| UA (1) | UA71890C2 (ref) |
| WO (1) | WO1998005335A1 (ref) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006056879A (ja) * | 2004-07-21 | 2006-03-02 | Kobe Univ | インスリン抵抗性の改善剤、及びそのスクリーニング方法 |
| JP2006513253A (ja) * | 2002-10-15 | 2006-04-20 | アイアールエム エルエルシー | 骨形成を誘導する組成物および方法 |
| JPWO2006051951A1 (ja) * | 2004-11-12 | 2008-05-29 | 一仁 富澤 | Ｃｄｋ５阻害剤を含む糖尿病治療薬 |
| JP2008540583A (ja) * | 2005-05-16 | 2008-11-20 | プロメティック・バイオサイエンスィズ・インコーポレーテッド | 自己免疫疾患を治療するための化合物とそれら化合物の使用 |
| JP2009516753A (ja) * | 2005-11-22 | 2009-04-23 | ザ スクリップス リサーチ インスティテュート | 高度に効力を持つエポチロンの化学合成 |
| JP2010539146A (ja) * | 2007-09-12 | 2010-12-16 | セントレ・ナショナル・デ・ラ・レシェルシェ・サイエンティフィーク | 医薬品の製造のためにプリン誘導体を使用する方法 |
| JP2018515434A (ja) * | 2015-03-27 | 2018-06-14 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | サイクリン依存性キナーゼの阻害剤 |
| US10870651B2 (en) | 2014-12-23 | 2020-12-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
| US10906889B2 (en) | 2013-10-18 | 2021-02-02 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7) |
| US10981903B2 (en) | 2011-11-17 | 2021-04-20 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-Jun-N-terminal kinase (JNK) |
| US11142507B2 (en) | 2015-09-09 | 2021-10-12 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
| US11826365B2 (en) | 2009-12-29 | 2023-11-28 | Dana-Farber Cancer Institute, Inc. | Type II raf kinase inhibitors |
| US12187701B2 (en) | 2018-06-25 | 2025-01-07 | Dana-Farber Cancer Institute, Inc. | Taire family kinase inhibitors and uses thereof |
Families Citing this family (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT874846E (pt) * | 1995-11-01 | 2003-08-29 | Novartis Ag | Derivados de purina e processos para a sua preparacao |
| FR2741881B1 (fr) * | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
| US6790958B2 (en) * | 1996-08-02 | 2004-09-14 | Robert T. Lum | Purine inhibitors of cyclin dependent kinase 2 & IKBA |
| WO1998016528A1 (en) * | 1996-10-11 | 1998-04-23 | Chiron Corporation | Purine inhibitors of glycogen synthase kinase 3 (gsk3) |
| DE19653646A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung |
| AU744986B2 (en) * | 1997-07-12 | 2002-03-07 | Cancer Research Technology Limited | Cyclin dependent kinase inhibiting purine derivatives |
| AU735127B2 (en) | 1997-08-07 | 2001-06-28 | Regents Of The University Of California, The | Purine inhibitor of protein kinases, G proteins and polymerases |
| US6573044B1 (en) * | 1997-08-07 | 2003-06-03 | The Regents Of The University Of California | Methods of using chemical libraries to search for new kinase inhibitors |
| EP1418244A1 (en) * | 1997-12-19 | 2004-05-12 | Affymetrix, Inc. | Exploiting genomics in the search for new drugs |
| ATE260989T1 (de) | 1997-12-19 | 2004-03-15 | Affymetrix Inc | Erkenntnisse der genomforschung für die suche nach neuartigen wirkstoffen |
| US6479487B1 (en) | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
| US6642231B2 (en) * | 1998-02-26 | 2003-11-04 | Aventis Pharmaceuticals Inc. | 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
| US6413974B1 (en) | 1998-02-26 | 2002-07-02 | Aventis Pharmaceuticals Inc. | 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines |
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| JP2018515434A (ja) * | 2015-03-27 | 2018-06-14 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | サイクリン依存性キナーゼの阻害剤 |
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| JP2021107396A (ja) * | 2015-03-27 | 2021-07-29 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | サイクリン依存性キナーゼの阻害剤 |
| USRE50776E1 (en) | 2015-03-27 | 2026-02-03 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
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| US12187701B2 (en) | 2018-06-25 | 2025-01-07 | Dana-Farber Cancer Institute, Inc. | Taire family kinase inhibitors and uses thereof |
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