IS7291A - Merkt kirni - Google Patents

Merkt kirni

Info

Publication number
IS7291A
IS7291A IS7291A IS7291A IS7291A IS 7291 A IS7291 A IS 7291A IS 7291 A IS7291 A IS 7291A IS 7291 A IS7291 A IS 7291A IS 7291 A IS7291 A IS 7291A
Authority
IS
Iceland
Prior art keywords
kirni
marked
marked kirni
Prior art date
Application number
IS7291A
Other languages
English (en)
Inventor
Balasubramanian Shankar
Barnes Colin
Liu Xiaohai
Swerdlow Harold
Original Assignee
Solexa Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26246831&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS7291(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB0129012.1A external-priority patent/GB0129012D0/en
Application filed by Solexa Limited filed Critical Solexa Limited
Publication of IS7291A publication Critical patent/IS7291A/is

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10Modifications characterised by
    • C12Q2525/186Modifications characterised by incorporating a non-extendable or blocking moiety
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/113Cycle sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
IS7291A 2001-12-04 2004-06-01 Merkt kirni IS7291A (is)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0129012.1A GB0129012D0 (en) 2001-12-04 2001-12-04 Labelled nucleotides
US10/227,131 US7057026B2 (en) 2001-12-04 2002-08-23 Labelled nucleotides
PCT/GB2002/005474 WO2003048387A2 (en) 2001-12-04 2002-12-04 Labelled nucleotides

Publications (1)

Publication Number Publication Date
IS7291A true IS7291A (is) 2004-06-01

Family

ID=26246831

Family Applications (1)

Application Number Title Priority Date Filing Date
IS7291A IS7291A (is) 2001-12-04 2004-06-01 Merkt kirni

Country Status (16)

Country Link
US (4) US7057026B2 (is)
EP (4) EP1451351B1 (is)
JP (1) JP2005511058A (is)
KR (1) KR20050044668A (is)
CN (1) CN1617937A (is)
AU (1) AU2002349155A1 (is)
BR (1) BR0214683A (is)
CA (1) CA2469066A1 (is)
CY (2) CY1118765T1 (is)
DK (2) DK3266791T3 (is)
ES (2) ES2858359T3 (is)
IL (1) IL162170A0 (is)
IS (1) IS7291A (is)
PT (2) PT3266791T (is)
SI (1) SI3266791T1 (is)
WO (1) WO2003048387A2 (is)

Families Citing this family (972)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
EP3034627B1 (en) 2000-10-06 2019-01-30 The Trustees of Columbia University in the City of New York Massive parallel method for decoding dna and rna
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
JP2004523243A (ja) 2001-03-12 2004-08-05 カリフォルニア インスティチュート オブ テクノロジー 非同期性塩基伸長によってポリヌクレオチド配列を分析するための方法および装置
US7057026B2 (en) * 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US20030215816A1 (en) * 2002-05-20 2003-11-20 Narayan Sundararajan Method for sequencing nucleic acids by observing the uptake of nucleotides modified with bulky groups
GB2395954A (en) 2002-08-23 2004-06-09 Solexa Ltd Modified nucleotides
ES2326077T3 (es) 2002-08-23 2009-09-30 Illumina Cambridge Limited Nucleotidos marcados.
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
AU2003297859A1 (en) * 2002-12-13 2004-07-09 The Trustees Of Columbia University In The City Of New York Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
US10533998B2 (en) 2008-07-18 2020-01-14 Bio-Rad Laboratories, Inc. Enzyme quantification
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US7572581B2 (en) 2003-06-30 2009-08-11 Roche Molecular Systems, Inc. 2′-terminator nucleotide-related methods and systems
WO2005044836A2 (de) 2003-11-05 2005-05-19 Genovoxx Gmbh Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
WO2005080605A2 (en) 2004-02-19 2005-09-01 Helicos Biosciences Corporation Methods and kits for analyzing polynucleotide sequences
EP2436778A3 (en) * 2004-03-03 2012-07-11 The Trustees of Columbia University in the City of New York Photocleavable fluorescent nucleotides for DNA sequencing on chip constructed by site-specific coupling chemistry
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
WO2006073436A2 (en) * 2004-04-29 2006-07-13 The Trustees Of Columbia University In The City Of New York Mass tag pcr for multiplex diagnostics
DE602005027700D1 (de) 2004-05-25 2011-06-09 Helicos Biosciences Corp Verfahren zur nukleinsäureimmobilisierung
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
GB0427236D0 (en) 2004-12-13 2005-01-12 Solexa Ltd Improved method of nucleotide detection
EP1828412B2 (en) * 2004-12-13 2019-01-09 Illumina Cambridge Limited Improved method of nucleotide detection
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
WO2006074351A2 (en) * 2005-01-05 2006-07-13 Agencourt Personal Genomics Reversible nucleotide terminators and uses thereof
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
EP2236628A3 (en) 2005-02-01 2010-10-13 AB Advanced Genetic Analysis Corporation Reagents, methods and libraries for bead-based sequencing
US20080003571A1 (en) 2005-02-01 2008-01-03 Mckernan Kevin Reagents, methods, and libraries for bead-based sequencing
GB0507835D0 (en) * 2005-04-18 2005-05-25 Solexa Ltd Method and device for nucleic acid sequencing using a planar wave guide
US8623628B2 (en) 2005-05-10 2014-01-07 Illumina, Inc. Polymerases
GB0509508D0 (en) * 2005-05-10 2005-06-15 Solexa Ltd Improved polymerases
US20060281100A1 (en) * 2005-06-14 2006-12-14 Shen Gene G Thiotriphosphate nucleotide dye terminators
US9169510B2 (en) * 2005-06-21 2015-10-27 The Trustees Of Columbia University In The City Of New York Pyrosequencing methods and related compositions
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US8796432B2 (en) 2005-10-31 2014-08-05 The Trustees Of Columbia University In The City Of New York Chemically cleavable 3'-o-allyl-DNTP-allyl-fluorophore fluorescent nucleotide analogues and related methods
GB2446084B (en) 2005-10-31 2011-03-02 Univ Columbia Synthesis of four color 3-o-allyl modified photocleavable fluorescent nucleotides and related methods
US20090088332A1 (en) * 2005-11-21 2009-04-02 Jingyue Ju Multiplex Digital Immuno-Sensing Using a Library of Photocleavable Mass Tags
WO2007081387A1 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices, methods of use, and kits for performing diagnostics
EP1977014A4 (en) * 2006-01-19 2009-09-02 Univ New York State Res Found METHOD AND DEVICES FOR DETECTING AND IDENTIFYING CODED BEADS AND BIOLOGICAL MOLECULES
US7397546B2 (en) 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
EP3722409A1 (en) 2006-03-31 2020-10-14 Illumina, Inc. Systems and devices for sequence by synthesis analysis
PL2963127T3 (pl) 2006-04-04 2018-01-31 Keygene Nv Wysokoprzepustowa detekcja markerów molekularnych na podstawie fragmentów restrykcyjnych
JP2009538123A (ja) * 2006-04-19 2009-11-05 アプライド バイオシステムズ, エルエルシー ゲル非含有ビーズベースの配列決定のための試薬、方法およびライブラリー
EP2481815B1 (en) 2006-05-11 2016-01-27 Raindance Technologies, Inc. Microfluidic devices
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2021415B1 (en) 2006-05-18 2017-03-15 Illumina Cambridge Limited Dye compounds and the use of their labelled conjugates
CN101495656B (zh) * 2006-06-07 2017-02-08 纽约哥伦比亚大学理事会 采用带修饰的核苷酸通过纳米通道进行dna序列测定
CN101506375A (zh) * 2006-06-30 2009-08-12 阿普里拉股份有限公司 可逆的终止子核苷酸和使用方法
EP2182079B1 (en) 2006-07-12 2014-09-10 Keygene N.V. High throughput physical mapping using AFLP
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
CA2660286A1 (en) 2006-08-09 2008-02-21 Homestead Clinical Corporation Organ-specific proteins and methods of their use
US8053191B2 (en) 2006-08-31 2011-11-08 Westend Asset Clearinghouse Company, Llc Iterative nucleic acid assembly using activation of vector-encoded traits
US8399188B2 (en) 2006-09-28 2013-03-19 Illumina, Inc. Compositions and methods for nucleotide sequencing
US8568979B2 (en) 2006-10-10 2013-10-29 Illumina, Inc. Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization
US20080242560A1 (en) * 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
GB2457402B (en) * 2006-12-01 2011-10-19 Univ Columbia Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
US7897737B2 (en) 2006-12-05 2011-03-01 Lasergen, Inc. 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
NZ577303A (en) * 2006-12-05 2011-12-22 Lasergen Inc Nucleotides and nucleosides having derivitized bases including a dye and terminating group and uses in DNA sequencing
WO2008093098A2 (en) 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
CN101631796B (zh) * 2007-03-09 2013-08-07 独立行政法人理化学研究所 具有由单核苷或单核苷酸衍生的结构的化合物、核酸、标记物以及核酸检测方法和试剂盒
JP5750209B2 (ja) 2007-03-16 2015-07-15 アプタ バイオサイエンス リミテッド 機能性分子、機能性分子合成用アミダイド、及び標的物質解析方法
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US7678894B2 (en) * 2007-05-18 2010-03-16 Helicos Biosciences Corporation Nucleotide analogs
US20090099027A1 (en) * 2007-08-23 2009-04-16 Applied Biosystems Inc. Methods of Modifying Support Surfaces for the Immobilization of Particles and the Use of the Immobilized Particles for Analyzing Nucleic Acids
US20090062132A1 (en) * 2007-08-29 2009-03-05 Borner Scott R Alternative nucleic acid sequencing methods
WO2009054922A1 (en) 2007-10-19 2009-04-30 The Trustees Of Columbia University In The City Of New York Dna sequencing with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators
WO2009051807A1 (en) 2007-10-19 2009-04-23 The Trustees Of Columbia University In The City Of New York Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis
US7811810B2 (en) 2007-10-25 2010-10-12 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US7767441B2 (en) * 2007-10-25 2010-08-03 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
WO2009067628A1 (en) 2007-11-20 2009-05-28 Applied Biosystems Inc. Reversible di-nucleotide terminator sequencing
US8652781B2 (en) 2008-02-12 2014-02-18 Pacific Biosciences Of California, Inc. Cognate sampling kinetics
RU2010142289A (ru) 2008-03-17 2012-04-27 Экспрессив Рисерч Б.В. (Nl) Обнаружение связанных с экспрессией генов
US9017973B2 (en) 2008-03-19 2015-04-28 Intelligent Biosystems, Inc. Methods and compositions for incorporating nucleotides
US8623598B2 (en) * 2008-03-19 2014-01-07 Intelligent Bio Systems, Inc. Methods and compositions for inhibiting undesired cleaving of labels
US8999676B2 (en) 2008-03-31 2015-04-07 Pacific Biosciences Of California, Inc. Recombinant polymerases for improved single molecule sequencing
US8420366B2 (en) * 2008-03-31 2013-04-16 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
WO2009145828A2 (en) * 2008-03-31 2009-12-03 Pacific Biosciences Of California, Inc. Two slow-step polymerase enzyme systems and methods
EP2271751B1 (en) * 2008-03-31 2015-07-22 Pacific Biosciences of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
US20110105356A1 (en) * 2008-05-07 2011-05-05 Derosier Chad F Compositions and methods for providing substances to and from an array
BRPI0915173B8 (pt) 2008-06-11 2021-05-25 Agilent Technologies Inc compostos de nucleotídeos e nucleosídeos e método de sequenciamento de um ácido nucleico-alvo
WO2010003132A1 (en) 2008-07-02 2010-01-07 Illumina Cambridge Ltd. Using populations of beads for the fabrication of arrays on surfaces
WO2010003153A2 (en) * 2008-07-03 2010-01-07 Life Technologies Corporation Methylation analysis of mate pairs
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US8173198B2 (en) * 2008-07-23 2012-05-08 Life Technologies Corporation Deposition of metal oxides onto surfaces as an immobilization vehicle for carboxylated or phophated particles or polymers
BRPI0918795A2 (pt) * 2008-09-03 2015-12-01 Quantumdx Group Ltd dispositivo e método de sequenciação de polinucleotídeo alvo
JP5822726B2 (ja) * 2008-09-03 2015-11-24 クワンタムディーエックス・グループ・リミテッド 電荷量タグを含む合成ヌクレオチドのデザイン、合成及び使用
WO2017120148A1 (en) 2016-01-04 2017-07-13 Quantumdx Group Limited Design, synthesis and use of synthetic nucleotides comprising charge mass tags
US10759824B2 (en) 2008-09-03 2020-09-01 Quantumdx Group Limited Design, synthesis and use of synthetic nucleotides comprising charge mass tags
CA2735979A1 (en) * 2008-09-05 2010-03-11 Pacific Biosciences Of California, Inc. Engineering polymerases and reaction conditions for modified incorporation properties
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
US8728764B2 (en) 2008-10-02 2014-05-20 Illumina Cambridge Limited Nucleic acid sample enrichment for sequencing applications
US8541207B2 (en) * 2008-10-22 2013-09-24 Illumina, Inc. Preservation of information related to genomic DNA methylation
US8486865B2 (en) 2008-11-03 2013-07-16 The Regents Of The University Of California Methods for detecting modification resistant nucleic acids
US8252910B2 (en) * 2008-11-19 2012-08-28 Pacific Biosciences Of California, Inc. Modular nucleotide compositions and uses therefor
EP2373817A4 (en) * 2008-12-10 2013-01-02 Illumina Inc METHOD AND COMPOSITIONS FOR HYBRIDIZING NUCLEIC ACIDS
EP2607496B1 (en) 2008-12-23 2014-07-16 Illumina, Inc. Methods useful in nucleic acid sequencing protocols
JP2012514977A (ja) 2009-01-13 2012-07-05 キージーン・エン・フェー 新規ゲノム配列決定戦略
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US20100261185A1 (en) 2009-03-27 2010-10-14 Life Technologies Corporation Labeled enzyme compositions, methods and systems
GB0907372D0 (en) 2009-04-29 2009-06-10 Invitrogen Dynal As Particles
US12129514B2 (en) 2009-04-30 2024-10-29 Molecular Loop Biosolutions, Llc Methods and compositions for evaluating genetic markers
CA2760439A1 (en) 2009-04-30 2010-11-04 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
US20100279882A1 (en) * 2009-05-01 2010-11-04 Mostafa Ronaghi Sequencing methods
WO2010141391A2 (en) 2009-06-05 2010-12-09 Life Technologies Corporation Mutant dna polymerases
WO2011011175A2 (en) 2009-07-24 2011-01-27 Illumina, Inc. Method for sequencing a polynucleotide template
DK2669387T3 (en) 2009-08-25 2016-09-19 Illumina Inc Methods of selection and amplification of polynucleotides
EP2486409A1 (en) 2009-10-09 2012-08-15 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
WO2011050938A1 (de) 2009-10-26 2011-05-05 Genovoxx Gmbh Konjugate von nukleotiden und methoden zu deren anwendung
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
PT2531880T (pt) 2010-02-01 2016-10-31 Illumina Inc Resumo
US9605307B2 (en) 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
US20110192723A1 (en) * 2010-02-08 2011-08-11 Genia Technologies, Inc. Systems and methods for manipulating a molecule in a nanopore
US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
EP4435111A1 (en) 2010-02-12 2024-09-25 Bio-Rad Laboratories, Inc. Digital analyte analysis
EP2539464B1 (en) 2010-02-23 2016-11-16 Illumina, Inc. Amplification methods to minimise sequence specific bias
DE202011003570U1 (de) 2010-03-06 2012-01-30 Illumina, Inc. Systeme und Vorrichtungen zum Detektieren optischer Signale aus einer Probe
US8951940B2 (en) 2010-04-01 2015-02-10 Illumina, Inc. Solid-phase clonal amplification and related methods
RS54482B1 (sr) 2010-04-05 2016-06-30 Prognosys Biosciences, Inc. Biološka testiranja sa prostornim kodiranjem
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
WO2011159942A1 (en) 2010-06-18 2011-12-22 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
WO2012009206A2 (en) 2010-07-12 2012-01-19 Pacific Biosciences Of California, Inc. Sequencing reactions with alkali metal cations for pulse width control
US9029103B2 (en) 2010-08-27 2015-05-12 Illumina Cambridge Limited Methods for sequencing polynucleotides
US20120070829A1 (en) 2010-09-10 2012-03-22 Bio-Rad Laboratories, Inc. Size selection of dna for chromatin analysis
US8483969B2 (en) 2010-09-17 2013-07-09 Illuminia, Inc. Variation analysis for multiple templates on a solid support
WO2012050920A1 (en) 2010-09-29 2012-04-19 Illumina, Inc. Compositions and methods for sequencing nucleic acids
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
WO2012055929A1 (en) 2010-10-26 2012-05-03 Illumina, Inc. Sequencing methods
WO2012058096A1 (en) 2010-10-27 2012-05-03 Illumina, Inc. Microdevices and biosensor cartridges for biological or chemical analysis and systems and methods for the same
US8575071B2 (en) 2010-11-03 2013-11-05 Illumina, Inc. Reducing adapter dimer formation
EP2635679B1 (en) 2010-11-05 2017-04-19 Illumina, Inc. Linking sequence reads using paired code tags
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
IL280133B2 (en) 2010-11-12 2023-04-01 Gen9 Inc Methods and devices for the synthesis of nucleic acids
EP4039363A1 (en) 2010-11-12 2022-08-10 Gen9, Inc. Protein arrays and methods of using and making the same
WO2012074855A2 (en) 2010-11-22 2012-06-07 The Regents Of The University Of California Methods of identifying a cellular nascent rna transcript
WO2013082164A1 (en) 2011-11-28 2013-06-06 Life Technologies Corporation Enhanced ligation reactions
GB2500360B (en) 2010-12-22 2019-10-23 Genia Tech Inc Nanopore-based single DNA molecule characterization, identification and isolation using speed bumps
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
US8883764B1 (en) 2011-01-19 2014-11-11 Illumina, Inc. Formylpyrrole-based heterocycles for nucleic acid attachment to supports
US8962242B2 (en) 2011-01-24 2015-02-24 Genia Technologies, Inc. System for detecting electrical properties of a molecular complex
US9110478B2 (en) 2011-01-27 2015-08-18 Genia Technologies, Inc. Temperature regulation of measurement arrays
CN103403188B (zh) 2011-01-31 2016-03-30 伊鲁米那股份有限公司 用于降低核酸损伤的方法
US10457936B2 (en) 2011-02-02 2019-10-29 University Of Washington Through Its Center For Commercialization Massively parallel contiguity mapping
US9364803B2 (en) 2011-02-11 2016-06-14 Raindance Technologies, Inc. Methods for forming mixed droplets
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
EP2702171A1 (de) 2011-04-27 2014-03-05 Cherkasov, Dmitry Methoden und komponenten zur detektion von nukleinsäureketten
DE102012008759A1 (de) 2011-05-04 2012-11-08 Genovoxx Gmbh Nukleosid-Triphosphat-Konjugate und Methoden zu deren Anwendung
WO2012162429A2 (en) 2011-05-23 2012-11-29 The Trustees Of Columbia University In The City Of New York Dna sequencing by synthesis using raman and infrared spectroscopy detection
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
WO2012170936A2 (en) 2011-06-09 2012-12-13 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
WO2013009175A1 (en) 2011-07-08 2013-01-17 Keygene N.V. Sequence based genotyping based on oligonucleotide ligation assays
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP3594340B1 (en) 2011-08-26 2021-06-30 Gen9, Inc. Compositions and methods for high fidelity assembly of nucleic acids
EP2755984B1 (en) 2011-09-13 2020-02-12 Agilent Technologies, Inc. 5-methoxy. 3'-oh unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
US10152569B2 (en) 2011-09-26 2018-12-11 Gen-Probe Incorporated Algorithms for sequence determinations
US10378051B2 (en) 2011-09-29 2019-08-13 Illumina Cambridge Limited Continuous extension and deblocking in reactions for nucleic acids synthesis and sequencing
EP2768983A4 (en) 2011-10-17 2015-06-03 Good Start Genetics Inc METHODS OF IDENTIFYING MUTATIONS ASSOCIATED WITH DISEASES
EP3305400A3 (en) 2011-10-28 2018-06-06 Illumina, Inc. Microarray fabrication system and method
WO2013070627A2 (en) 2011-11-07 2013-05-16 Illumina, Inc. Integrated sequencing apparatuses and methods of use
US9200274B2 (en) 2011-12-09 2015-12-01 Illumina, Inc. Expanded radix for polymeric tags
WO2013096692A1 (en) 2011-12-21 2013-06-27 Illumina, Inc. Apparatus and methods for kinetic analysis and determination of nucleic acid sequences
WO2013117595A2 (en) 2012-02-07 2013-08-15 Illumina Cambridge Limited Targeted enrichment and amplification of nucleic acids on a support
EP2817418B1 (en) 2012-02-24 2017-10-11 Raindance Technologies, Inc. Labeling and sample preparation for sequencing
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
NO2694769T3 (is) 2012-03-06 2018-03-03
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
US20130261984A1 (en) 2012-03-30 2013-10-03 Illumina, Inc. Methods and systems for determining fetal chromosomal abnormalities
JPWO2013150902A1 (ja) * 2012-04-02 2015-12-17 国立研究開発法人理化学研究所 非天然型塩基を含むオリゴデオキシヌクレオチドの切断による5’末端リン酸化オリゴデオキシヌクレオチドの製造方法
JP6159391B2 (ja) 2012-04-03 2017-07-05 イラミーナ インコーポレーテッド 核酸シークエンシングに有用な統合化した読取りヘッド及び流体カートリッジ
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US9444880B2 (en) 2012-04-11 2016-09-13 Illumina, Inc. Cloud computing environment for biological data
US20130274148A1 (en) 2012-04-11 2013-10-17 Illumina, Inc. Portable genetic detection and analysis system and method
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
AU2013251701A1 (en) 2012-04-24 2014-10-30 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
WO2013185137A1 (en) 2012-06-08 2013-12-12 Pacific Biosciences Of California, Inc. Modified base detection with nanopore sequencing
US8895249B2 (en) 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries
US9494554B2 (en) 2012-06-15 2016-11-15 Genia Technologies, Inc. Chip set-up and high-accuracy nucleic acid sequencing
JP6509727B2 (ja) * 2012-06-25 2019-05-15 ギンゴー バイオワークス, インコーポレイテッド 核酸アセンブリおよび高処理シークエンシングのための方法
CA2878291A1 (en) 2012-07-03 2014-01-09 Sloan Kettering Institute For Cancer Research Quantitative assessment of human t-cell repertoire recovery after allogeneic hematopoietic stem cell transplantation
US9092401B2 (en) 2012-10-31 2015-07-28 Counsyl, Inc. System and methods for detecting genetic variation
JP6285929B2 (ja) 2012-07-17 2018-02-28 カウンシル,インコーポレーテッド 遺伝的変異を検出するためのシステムおよび方法
US9422602B2 (en) 2012-08-15 2016-08-23 Bio-Rad Laboratories, Inc. Methods and compositions for determining nucleic acid degradation
NL2017959B1 (en) 2016-12-08 2018-06-19 Illumina Inc Cartridge assembly
CA3178340C (en) 2012-08-20 2025-10-14 Illumina, Inc. METHOD AND SYSTEM FOR FLUORESCENCE LIFETIME-BASED SEQUENCING
US9150896B2 (en) 2012-09-06 2015-10-06 Illumina, Inc. Nucleotides and primers with removable blocking groups
US9279016B2 (en) 2012-09-19 2016-03-08 Abbvie Biotherapeutics Inc. Methods for identifying antibodies with reduced immunogenicity
US9399766B2 (en) 2012-10-01 2016-07-26 Pacific Biosciences Of California, Inc. Recombinant polymerases for incorporation of protein shield nucleotide analogs
EP2909337B1 (en) 2012-10-17 2019-01-09 Spatial Transcriptomics AB Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
US9181583B2 (en) 2012-10-23 2015-11-10 Illumina, Inc. HLA typing using selective amplification and sequencing
US9116139B2 (en) 2012-11-05 2015-08-25 Illumina, Inc. Sequence scheduling and sample distribution techniques
US9605309B2 (en) 2012-11-09 2017-03-28 Genia Technologies, Inc. Nucleic acid sequencing using tags
WO2014078855A1 (en) 2012-11-19 2014-05-22 Apton Biosystems, Inc. Digital analysis of molecular analytes using single molecule detection
US10378053B2 (en) 2017-03-17 2019-08-13 Apton Biosystems, Inc. Sequencing and high resolution imaging
US10829816B2 (en) 2012-11-19 2020-11-10 Apton Biosystems, Inc. Methods of analyte detection
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
CN103087131B (zh) * 2013-01-15 2015-07-08 上海交通大学 可逆终端及其合成和在dna合成测序中的用途
US9805407B2 (en) 2013-01-25 2017-10-31 Illumina, Inc. Methods and systems for using a cloud computing environment to configure and sell a biological sample preparation cartridge and share related data
US9759711B2 (en) 2013-02-05 2017-09-12 Genia Technologies, Inc. Nanopore arrays
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
US9650406B2 (en) 2013-02-28 2017-05-16 Centrillion Technology Holdings Corporation Reversible terminator molecules and methods of their use
US9914979B2 (en) 2013-03-04 2018-03-13 Fry Laboratories, LLC Method and kit for characterizing microorganisms
CA2902099C (en) 2013-03-08 2020-06-02 F. Hoffmann-La Roche Ag Egfr mutation blood testing
EP2970951B1 (en) 2013-03-13 2019-02-20 Illumina, Inc. Methods for nucleic acid sequencing
ES2878525T3 (es) 2013-03-13 2021-11-19 Illumina Inc Dispositivos fluídicos multicapa y procedimientos para su fabricación
EP2971159B1 (en) 2013-03-14 2019-05-08 Molecular Loop Biosolutions, LLC Methods for analyzing nucleic acids
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
WO2014142921A1 (en) 2013-03-14 2014-09-18 Illumina, Inc. Modified polymerases for improved incorporation of nucleotide analogues
WO2014139596A1 (en) * 2013-03-15 2014-09-18 Illumina Cambridge Limited Modified nucleosides or nucleotides
US20140274747A1 (en) 2013-03-15 2014-09-18 Illumina, Inc. Super resolution imaging
EP2971071B1 (en) 2013-03-15 2018-02-28 Illumina, Inc. Enzyme-linked nucleotides
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
US9255265B2 (en) 2013-03-15 2016-02-09 Illumina, Inc. Methods for producing stranded cDNA libraries
US10648026B2 (en) 2013-03-15 2020-05-12 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
US9193998B2 (en) 2013-03-15 2015-11-24 Illumina, Inc. Super resolution imaging
US8847799B1 (en) 2013-06-03 2014-09-30 Good Start Genetics, Inc. Methods and systems for storing sequence read data
CN105849275B (zh) 2013-06-25 2020-03-17 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
JP6511046B2 (ja) 2013-07-01 2019-05-08 イルミナ インコーポレイテッド 触媒を使用しない表面官能基化およびポリマーグラフト
WO2015002789A1 (en) 2013-07-03 2015-01-08 Illumina, Inc. Sequencing by orthogonal synthesis
SI3030645T1 (sl) 2013-08-08 2023-03-31 Illumina, Inc. Fluidni sistem za dovajanje reagenta v pretočno celico
CA2921809A1 (en) 2013-08-22 2015-02-26 Apton Biosystems, Inc. Digital analysis of molecular analytes using electrical methods
EP3038649B1 (en) 2013-08-26 2019-09-25 The Translational Genomics Research Institute Single molecule-overlapping read analysis for minor variant mutation detection in pathogen samples
AU2014312043A1 (en) 2013-08-30 2016-02-25 Illumina France Manipulation of droplets on hydrophilic or variegated-hydrophilic surfaces
CN103484106B (zh) * 2013-09-05 2015-08-19 上海交通大学 四色荧光标记可逆终端及其在dna测序中的用途
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
EP3053072B1 (en) 2013-10-04 2024-02-21 Life Technologies Corporation Methods and systems for modeling phasing effects in sequencing using termination chemistry
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9551697B2 (en) 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
US11041203B2 (en) 2013-10-18 2021-06-22 Molecular Loop Biosolutions, Inc. Methods for assessing a genomic region of a subject
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
CN105723222B (zh) 2013-10-23 2019-01-22 吉尼亚科技公司 使用纳米孔的高速分子感测
US9322062B2 (en) 2013-10-23 2016-04-26 Genia Technologies, Inc. Process for biosensor well formation
US10540783B2 (en) 2013-11-01 2020-01-21 Illumina, Inc. Image analysis useful for patterned objects
CN105980580B (zh) 2013-11-17 2020-03-03 宽腾矽公司 用于探测、检测和分析分子的光学系统和测定芯片
EP2876166B1 (en) * 2013-11-20 2016-12-14 Roche Diagnostics GmbH New compound for sequencing by synthesis
ES2808824T3 (es) 2013-12-03 2021-03-02 Illumina Inc Métodos y sistemas para analizar datos de imagen
KR102102934B1 (ko) 2013-12-10 2020-04-21 일루미나, 인코포레이티드 생물학적 또는 화학적 분석을 위한 바이오센서들 및 이를 제조하기 위한 방법
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
CN106414765A (zh) 2013-12-20 2017-02-15 Illumina公司 在片段化的基因组dna样品中保留基因组连接信息
CN106062212A (zh) 2013-12-23 2016-10-26 伊鲁米那股份有限公司 用于改进光发射检测的结构化基底和关于其的方法
US10537889B2 (en) 2013-12-31 2020-01-21 Illumina, Inc. Addressable flow cell using patterned electrodes
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
WO2015108663A1 (en) 2014-01-16 2015-07-23 Illumina, Inc. Amplicon preparation and sequencing on solid supports
US9677132B2 (en) 2014-01-16 2017-06-13 Illumina, Inc. Polynucleotide modification on solid support
AU2015217139B2 (en) 2014-02-13 2018-04-12 Illumina, Inc. Integrated consumer genomic services
BR122022007092B8 (pt) 2014-02-18 2023-01-31 Illumina Inc Método para construir um perfil de dna, método para construir uma biblioteca de ácido nucléico, biblioteca de ácido nucléico, pluralidade de iniciadores e kit
EP3698874B1 (en) 2014-03-11 2024-07-31 Illumina, Inc. Disposable, integrated microfluidic cartridge and methods of making the same
FR3020071B1 (fr) 2014-04-17 2017-12-22 Dna Script Procede de synthese d'acides nucleiques, notamment d'acides nucleiques de grande longueur, utilisation du procede et kit pour la mise en œuvre du procede
EP3137601B1 (en) 2014-04-29 2020-04-08 Illumina, Inc. Multiplexed single cell gene expression analysis using template switch and tagmentation
US11053548B2 (en) 2014-05-12 2021-07-06 Good Start Genetics, Inc. Methods for detecting aneuploidy
SG11201610168YA (en) 2014-05-16 2017-01-27 Illumina Inc Nucleic acid synthesis techniques
CN110038653A (zh) 2014-05-27 2019-07-23 伊鲁米那股份有限公司 包括基本仪器和可拆卸盒的用于生物化学分析的系统和方法
WO2015187670A2 (en) 2014-06-03 2015-12-10 Illumina, Inc. Compositions, systems, and methods for detecting events using tethers anchored to or adjacent to nanopores
US20150353989A1 (en) 2014-06-09 2015-12-10 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
AU2015273232B2 (en) 2014-06-13 2021-09-16 Illumina Cambridge Limited Methods and compositions for preparing sequencing libraries
US10829814B2 (en) 2014-06-19 2020-11-10 Illumina, Inc. Methods and compositions for single cell genomics
US10017759B2 (en) 2014-06-26 2018-07-10 Illumina, Inc. Library preparation of tagged nucleic acid
AU2015279794B2 (en) 2014-06-27 2021-09-30 Illumina, Inc. Modified polymerases for improved incorporation of nucleotide analogues
ES2713153T3 (es) 2014-06-30 2019-05-20 Illumina Inc Métodos y composiciones que utilizan la transposición unilateral
US10605766B2 (en) 2014-07-15 2020-03-31 Illumina, Inc. Biochemically activated electronic device
CA2955382C (en) 2014-07-21 2023-07-18 Illumina, Inc. Polynucleotide enrichment using crispr-cas systems
AU2015300779B2 (en) 2014-08-08 2021-03-04 Quantum-Si Incorporated Integrated device with external light source for probing, detecting, and analyzing molecules
MX2021007934A (es) 2014-08-08 2023-01-17 Quantum Si Inc Dispositivo integrado para el depósito temporal de fotones recibidos.
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
KR102738114B1 (ko) 2014-08-08 2024-12-06 퀀텀-에스아이 인코포레이티드 분자들을 프로빙, 검출 및 분석하기 위한 광학계 및 검정 칩
GB201414098D0 (en) * 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
US20160048608A1 (en) 2014-08-15 2016-02-18 Good Start Genetics, Inc. Systems and methods for genetic analysis
EP3183577B1 (en) 2014-08-21 2020-08-19 Illumina Cambridge Limited Reversible surface functionalization
FR3025201B1 (fr) 2014-09-02 2018-10-12 Dna Script Nucleotides modifies pour la synthese d'acides nucleiques, un kit renfermant de tels nucleotides et leur utilisation pour la production de genes ou sequences d'acides nucleiques synthetiques
US11408024B2 (en) 2014-09-10 2022-08-09 Molecular Loop Biosciences, Inc. Methods for selectively suppressing non-target sequences
WO2016040602A1 (en) 2014-09-11 2016-03-17 Epicentre Technologies Corporation Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv
EP3191606B1 (en) 2014-09-12 2020-05-27 Illumina, Inc. Methods for detecting the presence of polymer subunits using chemiluminescence
JP6802154B2 (ja) 2014-09-18 2020-12-16 イラミーナ インコーポレーテッド 核酸シーケンシングデータを解析するための方法およびシステム
EP3224595A4 (en) 2014-09-24 2018-06-13 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
DK3201355T3 (en) 2014-09-30 2019-10-14 Illumina Inc Modified polymerases for improved incorporation of nucleotide analogues
US10487357B2 (en) 2014-10-03 2019-11-26 Life Technologies Corporation Methods of nucleic acid analysis using terminator nucleotides
US10544455B2 (en) 2014-10-03 2020-01-28 Life Technologies Corporation Sequencing methods, compositions and systems using terminator nucleotides
MX391361B (es) 2014-10-09 2025-03-21 Illumina Inc Metodo y dispositivo para la separacion de liquidos inmiscibles para aislar de modo efectivo al menos uno de los liquidos.
US9897791B2 (en) 2014-10-16 2018-02-20 Illumina, Inc. Optical scanning systems for in situ genetic analysis
KR102472027B1 (ko) 2014-10-17 2022-11-30 일루미나 케임브리지 리미티드 근접 보존 전위
US10059929B2 (en) 2014-10-20 2018-08-28 Molecular Assemblies, Inc. Modified template-independent enzymes for polydeoxynucleotide synthesis
US10190162B2 (en) 2014-10-23 2019-01-29 Complete Genomics, Inc. Signal confinement sequencing (SCS) and nucleotide analogues for signal confinement sequencing
CN114805710B (zh) 2014-10-31 2023-11-17 伊鲁米纳剑桥有限公司 聚合物以及dna共聚物涂层
US10000799B2 (en) 2014-11-04 2018-06-19 Boreal Genomics, Inc. Methods of sequencing with linked fragments
GB201419731D0 (en) 2014-11-05 2014-12-17 Illumina Cambridge Ltd Sequencing from multiple primers to increase data rate and density
DK3215616T3 (da) 2014-11-05 2020-03-02 Illumina Cambridge Ltd Reducering af DNA-skade under prøvepræparering og sekventering ved anvendelse af siderophor-chelatorer
US10577649B2 (en) 2014-11-11 2020-03-03 Illumina, Inc. Polynucleotide amplification using CRISPR-Cas systems
KR102590448B1 (ko) 2014-11-11 2023-10-17 일루미나 케임브리지 리미티드 핵산의 모노클로날 클러스터를 형성시키고 시퀀싱하기 위한 방법 및 어레이
EP3227684B1 (en) 2014-12-03 2019-10-02 Isoplexis Corporation Analysis and screening of cell secretion profiles
CN107223161B (zh) 2014-12-15 2022-03-22 亿明达股份有限公司 用于基底上的单分子放置的组合物和方法
WO2016112073A1 (en) 2015-01-06 2016-07-14 Good Start Genetics, Inc. Screening for structural variants
KR20210135626A (ko) 2015-02-10 2021-11-15 일루미나, 인코포레이티드 세포 성분을 분석하기 위한 방법 및 조성물
CN107847930B (zh) 2015-03-20 2020-06-30 亿明达股份有限公司 在竖直或大致竖直的位置中使用的流体盒
US10300452B2 (en) 2015-03-24 2019-05-28 Pacific Biosciences Of California, Inc. Methods and compositions for single molecule composition loading
CN119779988A (zh) 2015-03-24 2025-04-08 伊鲁米那股份有限公司 对样品成像用于生物或化学分析的方法、载体组件和系统
ES2984193T3 (es) 2015-03-31 2024-10-29 Illumina Cambridge Ltd Concatemerización de moldes en la superficie
EP4119677B1 (en) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
EP3696536A1 (en) 2015-04-14 2020-08-19 Illumina, Inc. A method of manufacturing a substrate and a method of analyzing biomolecules capable of generating light emissions
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
US11180522B2 (en) * 2015-05-08 2021-11-23 Centrillion Technology Holdings Corporation Disulfide-linked reversible terminators
DK3760737T3 (en) 2015-05-11 2023-04-11 Illumina Inc Platform for discovery and analysis of therapeutic agents
SG11201708854PA (en) 2015-05-12 2017-11-29 Illumina Inc Field-effect apparatus and methods for sequencing nucelic acids
WO2016193695A1 (en) 2015-05-29 2016-12-08 Illumina Cambridge Limited Enhanced utilization of surface primers in clusters
EP3303584B1 (en) 2015-05-29 2019-10-09 Epicentre Technologies Corporation Methods of analyzing nucleic acids
BR112017025587B1 (pt) 2015-05-29 2022-09-27 Illumina, Inc Portador de amostra e sistema de ensaio para conduzir reações designadas
AU2016270887C1 (en) 2015-06-03 2025-01-16 Illumina, Inc. Compositions, systems, and methods for sequencing polynucleotides using tethers anchored to polymerases adjacent to nanopores
WO2016201142A1 (en) 2015-06-09 2016-12-15 Life Technologies Corporation Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging
WO2016205753A1 (en) 2015-06-17 2016-12-22 The Translational Genomics Research Institute Systems and methods for obtaining biological molecules from a sample
CN107922966B (zh) 2015-07-06 2022-06-28 伊卢米纳剑桥有限公司 用于核酸扩增的样品制备
US10857537B2 (en) 2015-07-06 2020-12-08 Illumina, Inc. Balanced AC modulation for driving droplet operations electrodes
CN107924121B (zh) 2015-07-07 2021-06-08 亿明达股份有限公司 经由纳米压印的选择性表面图案化
WO2017015018A1 (en) 2015-07-17 2017-01-26 Illumina, Inc. Polymer sheets for sequencing applications
JP6962914B2 (ja) 2015-07-20 2021-11-05 センティルス ホールディングカンパニー エルエルシーSentilus Holdco, Llc チップ、検出器、ならびにそれらの製造方法および使用方法
DK3329012T3 (da) 2015-07-27 2021-10-11 Illumina Inc Rumlig kortlægning af nukleinsyresekvensinformation
CN107771223B (zh) 2015-07-30 2022-03-22 亿明达股份有限公司 核苷酸的正交去封闭
WO2017030999A1 (en) 2015-08-14 2017-02-23 Illumina, Inc. Systems and methods using magnetically-responsive sensors for determining a genetic characteristic
EP3338096B1 (en) 2015-08-24 2024-03-06 Illumina, Inc. In-line pressure accumulator and flow-control system for biological or chemical assays
EP4368715A3 (en) 2015-08-28 2024-07-24 Illumina, Inc. Nucleic acid sequence analysis from single cells
EP3344389B1 (en) 2015-09-02 2020-06-10 Illumina Cambridge Limited Method of fixing defects in a hydrophobic surface of a droplet actuator
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US10450598B2 (en) 2015-09-11 2019-10-22 Illumina, Inc. Systems and methods for obtaining a droplet having a designated concentration of a substance-of-interest
US11085076B2 (en) 2015-09-28 2021-08-10 The Trustees Of Columbia University In The City Of New York Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
JP6657721B2 (ja) 2015-09-30 2020-03-04 ソニー株式会社 細胞の分析方法、細胞分析用チップ、細胞分析用試薬、細胞分析用キット及び細胞分析用装置
US10577643B2 (en) 2015-10-07 2020-03-03 Illumina, Inc. Off-target capture reduction in sequencing techniques
US10465232B1 (en) 2015-10-08 2019-11-05 Trace Genomics, Inc. Methods for quantifying efficiency of nucleic acid extraction and detection
US20190217300A1 (en) 2015-10-22 2019-07-18 Illumina, Inc. Filler fluid for fluidic devices
US11421264B2 (en) 2015-11-06 2022-08-23 IsoPlexis Corporation Thiol-containing cleave reagents and oxidative wash
TWI639614B (zh) 2015-11-06 2018-11-01 美商齊亞雋科學公司 核苷酸類似物
CN108472005B (zh) 2015-11-09 2021-09-14 瑞迪艾森有限公司 辐射屏蔽装置及其应用
US10253352B2 (en) 2015-11-17 2019-04-09 Omniome, Inc. Methods for determining sequence profiles
WO2017087696A1 (en) 2015-11-18 2017-05-26 Pacific Biosciences Of California, Inc. Methods and compositions for loading of polymerase complexes
CN116240272A (zh) 2015-11-19 2023-06-09 赛纳生物科技(北京)有限公司 一种用于获得多核苷酸的序列信息的试剂盒或系统
EP3384046B1 (en) 2015-12-01 2021-04-28 Illumina, Inc. Digital microfluidic system for single-cell isolation and characterization of analytes
EP4648053A3 (en) 2015-12-17 2026-01-07 Illumina, Inc. Distinguishing methylation levels in complex biological samples
TW201730563A (zh) 2016-01-11 2017-09-01 伊路米納有限公司 具有顯微螢光計、流體系統和流動單元閂鎖夾持模組的檢測裝置
JP2019512090A (ja) 2016-02-17 2019-05-09 テッセラクト ヘルス インコーポレイテッドTesseract Health,Inc. 寿命イメージングおよび検出用途のためのセンサおよびデバイス
SG10201906262UA (en) 2016-03-24 2019-08-27 Illumina Inc Photonic superlattice-based devices and compositions for use in luminescent imaging, and methods of using the same
WO2017168329A1 (en) 2016-03-28 2017-10-05 Boreal Genomics, Inc. Droplet-based linked-fragment sequencing
US10961573B2 (en) 2016-03-28 2021-03-30 Boreal Genomics, Inc. Linked duplex target capture
SG11201805665UA (en) 2016-03-28 2018-10-30 Illumina Inc Multi-plane microarrays
EP3458082A4 (en) * 2016-04-04 2020-07-29 The Trustees of Columbia University in the City of New York SYNTHESIS DNA SEQUENCING WITH NUCLEOTID ANALOGUES AND RAMAN DETECTION
US11326206B2 (en) 2016-04-07 2022-05-10 Pacific Biosciences Of California, Inc. Methods of quantifying target nucleic acids and identifying sequence variants
CA3016221C (en) 2016-04-07 2021-09-28 Illumina, Inc. Methods and systems for construction of normalized nucleic acid libraries
AU2017254688B2 (en) 2016-04-22 2020-05-14 Pacific Biosciences Of California, Inc. Nucleic acid sequencing method and system employing enhanced detection of nucleotide-specific ternary complex formation
RU2731841C2 (ru) 2016-04-22 2020-09-08 Иллюмина, Инк. Устройство и способ на основе фотонных структур для использования при получении люминесцентных изображений сайтов, находящихся в пределах пикселя
US10294514B2 (en) 2016-04-29 2019-05-21 Omniome, Inc. Sequencing method employing ternary complex destabilization to identify cognate nucleotides
US10597643B2 (en) 2016-04-29 2020-03-24 Omniome, Inc. Polymerases engineered to reduce nucleotide-independent DNA binding
KR102231977B1 (ko) 2016-04-29 2021-03-24 옴니옴 인코포레이티드 핵산 서열의 결정 방법
US11542544B2 (en) 2016-05-11 2023-01-03 Illumina, Inc. Polynucleotide enrichment and amplification using CRISPR-Cas or Argonaute systems
WO2017201073A1 (en) * 2016-05-16 2017-11-23 Nanostring Technologies, Inc. Methods for detecting target nucleic acids in a sample
US10900076B2 (en) 2016-05-18 2021-01-26 Illumina, Inc. Self assembled patterning using patterned hydrophobic surfaces
CN109661232B (zh) * 2016-05-23 2023-03-03 纽约哥伦比亚大学董事会 核苷酸衍生物及其使用方法
FI3464628T3 (fi) 2016-06-06 2024-05-03 Redvault Biosciences Lp Kohdereportterikonstruktit ja niiden käyttö
SG11201811504PA (en) 2016-07-22 2019-01-30 Univ Oregon Health & Science Single cell whole genome libraries and combinatorial indexing methods of making thereof
KR102230444B1 (ko) 2016-08-15 2021-03-23 옴니옴 인코포레이티드 핵산을 시퀀싱하기 위한 방법 및 시스템
US10428378B2 (en) 2016-08-15 2019-10-01 Omniome, Inc. Sequencing method for rapid identification and processing of cognate nucleotide pairs
US20200166518A1 (en) 2016-09-12 2020-05-28 IsoPlexis Corporation System and methods for multiplexed analysis of cellular and other immunotherapeutics
KR102416441B1 (ko) 2016-09-22 2022-07-04 일루미나, 인코포레이티드 체세포 복제수 변이 검출
WO2018064116A1 (en) 2016-09-28 2018-04-05 Illumina, Inc. Methods and systems for data compression
IL290157B2 (en) 2016-10-14 2023-09-01 Illumina Inc cartridge kit
US20180127816A1 (en) 2016-10-19 2018-05-10 Illumina, Inc. Methods for chemical ligation of nucleic acids
EP3535407B1 (en) * 2016-11-04 2021-06-02 Qiagen Sciences, LLC Thiol-containing cleave reagents and oxidative wash
JP7348066B2 (ja) 2016-11-11 2023-09-20 アイソプレキシス コーポレイション 単一細胞のゲノム、トランスクリプトームおよびプロテオームの同時解析のための組成物および方法
CN110168648A (zh) 2016-11-16 2019-08-23 伊路米纳有限公司 序列变异识别的验证方法和系统
GB201619458D0 (en) 2016-11-17 2017-01-04 Spatial Transcriptomics Ab Method for spatial tagging and analysing nucleic acids in a biological specimen
US10415080B2 (en) * 2016-11-21 2019-09-17 Nanostring Technologies, Inc. Chemical compositions and methods of using same
WO2018098372A1 (en) 2016-11-22 2018-05-31 IsoPlexis Corporation Systems, devices and methods for cell capture and methods of manufacture thereof
EP3551769A4 (en) 2016-12-09 2020-10-28 Boreal Genomics, Inc. LINKED LIGATURE
SI3551753T1 (sl) 2016-12-09 2022-09-30 The Broad Institute, Inc. Diagnostika, temelječa na sistemu CRISPR EFFECTOR
WO2018119063A1 (en) 2016-12-22 2018-06-28 Illumina, Inc. Arrays with quality control tracers
CN118099177A (zh) 2016-12-22 2024-05-28 宽腾矽公司 具有直接合并像素的整合式光电侦测器
MY204003A (en) 2016-12-22 2024-07-31 Illumina Inc Arrays including a resin film and a patterned polymer layer
US11466321B2 (en) 2016-12-22 2022-10-11 Illumina, Inc. Array including sequencing primer and non-sequencing entity
US11248254B2 (en) 2016-12-30 2022-02-15 Omniome, Inc. Method and system employing distinguishable polymerases for detecting ternary complexes and identifying cognate nucleotides
GB201704754D0 (en) 2017-01-05 2017-05-10 Illumina Inc Kinetic exclusion amplification of nucleic acid libraries
KR102629171B1 (ko) 2017-01-06 2024-01-25 일루미나, 인코포레이티드 페이징 보정
WO2018128544A1 (en) 2017-01-06 2018-07-12 Agendia N.V. Biomarkers for selecting patient groups, and uses thereof.
EP3568490B1 (en) 2017-01-10 2021-03-10 Omniome, Inc. Polymerases engineered to reduce nucleotide-independent dna binding
CN110178184B (zh) 2017-01-17 2024-04-19 Illumina公司 致癌剪接变体确定
EP3571616B1 (en) 2017-01-18 2021-05-19 Illumina, Inc. Methods and systems for generation and error-correction of unique molecular index sets with heterogeneous molecular lengths
EP3571319A1 (en) 2017-01-20 2019-11-27 Omniome, Inc. Process for cognate nucleotide detection in a nucleic acid sequencing workflow
SG11201906567YA (en) 2017-01-20 2019-08-27 Omniome Inc Allele-specific capture of nucleic acids
WO2018136118A1 (en) 2017-01-20 2018-07-26 Omniome, Inc. Genotyping by polymerase binding
GB201700983D0 (en) 2017-01-20 2017-03-08 Life Tech As Polymeric particles
GB201701686D0 (en) 2017-02-01 2017-03-15 Illunina Inc System & method with fiducials having offset layouts
GB201701688D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials in non-recliner layouts
GB201701689D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials of non-closed shapes
US11896944B2 (en) 2017-02-01 2024-02-13 Illumina, Inc. System and method with fiducials responding to multiple excitation frequencies
US11492666B2 (en) 2017-02-15 2022-11-08 Pacific Biosciences Of California, Inc. Distinguishing sequences by detecting polymerase dissociation
CN109642259A (zh) 2017-02-17 2019-04-16 阿姆斯特丹自由大学医学中心基金会 使用肿瘤教育的血小板的针对癌症的群智能增强的诊断和治疗选择
EP3452621B1 (en) 2017-02-21 2022-09-21 Illumina Inc. Tagmentation using immobilized transposomes with linkers
EP3596099B1 (en) 2017-03-06 2024-07-24 Singular Genomics Systems, Inc. Nucleic acid sequencing-by-synthesis (sbs) methods that combine sbs cycle steps
US11174515B2 (en) 2017-03-15 2021-11-16 The Broad Institute, Inc. CRISPR effector system based diagnostics
US11104937B2 (en) 2017-03-15 2021-08-31 The Broad Institute, Inc. CRISPR effector system based diagnostics
BR112019019087A2 (pt) 2017-03-15 2020-05-12 The Broad Institute, Inc. Diagnóstico baseado em sistema efetor de crispr para detecção de vírus
US11021740B2 (en) 2017-03-15 2021-06-01 The Broad Institute, Inc. Devices for CRISPR effector system based diagnostics
JP7062681B2 (ja) 2017-03-20 2022-05-06 イルミナ インコーポレイテッド 核酸ライブラリを調製するための方法および組成物
EP3601611B1 (en) 2017-03-24 2022-01-05 Life Technologies Corporation Polynucleotide adapters and methods of use thereof
CN119639879A (zh) 2017-03-28 2025-03-18 哥伦比亚大学董事会 用于连接荧光标记与用于dna合成测序的碱基的具有不同可裂解连接子的3'-o-改性的核苷酸类似物
EP3607087A4 (en) 2017-04-04 2020-12-30 Omniome, Inc. FLUIDIC APPARATUS AND USEFUL METHODS FOR CHEMICAL AND BIOLOGICAL REACTIONS
DK3615691T3 (da) 2017-04-23 2021-07-26 Illumina Inc Sammensætninger og fremgangsmåder til forbedring af prøveidentifikation i indekserede nukleinsyrebiblioteker
CA3059840C (en) 2017-04-23 2022-04-26 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
WO2018197945A1 (en) 2017-04-23 2018-11-01 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
EP3615690B1 (en) 2017-04-23 2021-09-08 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
US9951385B1 (en) 2017-04-25 2018-04-24 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
US11028435B2 (en) 2017-05-01 2021-06-08 Illumina, Inc. Optimal index sequences for multiplex massively parallel sequencing
AU2018266377B2 (en) 2017-05-08 2024-06-20 Illumina, Inc. Universal short adapters for indexing of polynucleotide samples
EP4293122B1 (en) 2017-06-07 2025-02-12 Oregon Health & Science University Single cell whole genome libraries for methylation sequencing
WO2018231818A1 (en) 2017-06-16 2018-12-20 Life Technologies Corporation Control nucleic acids, and compositions, kits, and uses thereof
CN111032882A (zh) 2017-06-20 2020-04-17 伊鲁米那股份有限公司 解决扩增反应中低效的方法和组合物
GB201711219D0 (en) 2017-07-12 2017-08-23 Illumina Cambridge Ltd Short pendant arm linkers for nucleotides in sequencing applications
AU2018302034B2 (en) 2017-07-18 2021-05-20 Pacific Biosciences Of California, Inc. Method of chemically modifying plastic surfaces
BR112020000697A2 (pt) 2017-07-24 2020-07-14 Quantum-Si Incorporated composições reagentes marcadas de alta intensidade e métodos para sequenciamento
US12078596B2 (en) 2017-07-24 2024-09-03 Quantum-Si Incorporated Hand-held, massively-parallel, bio-optoelectronic instrument
US20200202977A1 (en) 2017-07-31 2020-06-25 Illumina, Inc. Sequencing system with multiplexed biological sample aggregation
JP6998404B2 (ja) 2017-08-01 2022-02-04 深▲セン▼恒特基因有限公司 標的ヌクレオチド配列の富化及び決定方法
SG11201911871TA (en) 2017-08-01 2020-01-30 Illumina Inc Hydrogel beads for nucleotide sequencing
EP3662083B1 (en) 2017-08-01 2024-08-28 Illumina, Inc. Spatial indexing of genetic material and library preparation using hydrogel beads and flow cells
PT3663407T (pt) 2017-08-01 2023-03-27 Complete Genomics Inc Método de sequenciamento de ácidos nucleicos
WO2019030149A1 (en) 2017-08-07 2019-02-14 Dna Script VARIANTS OF FAMILY A DNA POLYMERASE AND USES THEREOF
CN111182972B (zh) 2017-08-15 2022-03-08 欧姆尼奥姆股份有限公司 用于检测化学和生物分析物的扫描装置和方法
US11993813B2 (en) 2017-08-31 2024-05-28 Mgi Tech Co., Ltd. Nucleic acid probe and nucleic acid sequencing method
US11447818B2 (en) 2017-09-15 2022-09-20 Illumina, Inc. Universal short adapters with variable length non-random unique molecular identifiers
AU2018336785B2 (en) 2017-09-20 2022-07-14 Regeneron Pharmaceuticals, Inc. Immunotherapy methods for patients whose tumors carry a high passenger gene mutation burden
CN120210336A (zh) 2017-10-06 2025-06-27 10X基因组学有限公司 Rna模板化连接
IL284711B2 (en) 2017-10-16 2025-04-01 Illumina Inc Classification of cutting sites by deep learning
AU2018350891B9 (en) 2017-10-16 2022-05-19 Illumina, Inc. Deep learning-based techniques for training deep convolutional neural networks
US11193166B2 (en) 2017-10-19 2021-12-07 Omniome, Inc. Simultaneous background reduction and complex stabilization in binding assay workflows
ES2966831T3 (es) 2017-11-06 2024-04-24 Illumina Inc Técnicas de indexación de ácidos nucleicos
KR102667912B1 (ko) 2017-11-16 2024-05-21 일루미나, 인코포레이티드 미세부수체 불안정성을 결정하기 위한 시스템 및 방법
CN111741967A (zh) 2017-11-30 2020-10-02 深圳市真迈生物科技有限公司 核苷类似物、制备方法及应用
KR102356323B1 (ko) 2017-11-30 2022-01-26 일루미나, 인코포레이티드 서열 변이체 콜에 대한 검증방법 및 시스템
JP6868541B2 (ja) * 2017-12-05 2021-05-12 イルミナ ケンブリッジ リミテッド 修飾ヌクレオシドまたは修飾ヌクレオチド
KR102871187B1 (ko) 2017-12-29 2025-10-14 노틸러스 서브시디어리, 인크. 단백질 식별을 위한 디코딩 접근법
US10752887B2 (en) 2018-01-08 2020-08-25 Dna Script Variants of terminal deoxynucleotidyl transferase and uses thereof
NZ759650A (en) 2018-01-08 2022-07-01 Illumina Inc High-throughput sequencing with semiconductor-based detection
AU2019205606A1 (en) 2018-01-08 2020-07-30 Centre National De La Recherche Scientifique Variants of Terminal deoxynucleotidyl Transferase and uses thereof
WO2019136388A1 (en) 2018-01-08 2019-07-11 Illumina, Inc. Systems and devices for high-throughput sequencing with semiconductor-based detection
AU2019206709B2 (en) 2018-01-15 2021-09-09 Illumina Cambridge Limited Deep learning-based variant classifier
US10844430B2 (en) 2018-01-24 2020-11-24 Qiagen Sciences, Llc DNA sequencing reaction additive
KR102857066B1 (ko) 2018-01-29 2025-09-08 더 브로드 인스티튜트, 인코퍼레이티드 Crispr 이펙터 시스템 기반 진단
EP3749777A4 (en) 2018-02-06 2021-11-24 Omniome, Inc. COMPOSITIONS AND TECHNIQUES FOR NUCLEIC ACID PRIMER EXTENSION
DK3752634T3 (da) 2018-02-13 2022-10-24 Illumina Inc DNA Sequencing Using Hydrogel Beads / DNA-sekventering ved anvendelse af hydrogelkorn
MX2019015011A (es) 2018-02-16 2021-01-08 Illumina Inc Nucleótidos etiquetados con carga y métodos de uso de los mismos.
WO2019164977A1 (en) 2018-02-21 2019-08-29 Singular Genomics Systems, Inc. Fluorinated nucleotides and uses thereof
EP3765028A4 (en) 2018-03-15 2021-12-15 The Trustees of Columbia University in the City of New York NUCLEOTID ANALOGUES AND THEIR USE FOR NUCLEIC ACID SEQUENCING AND ANALYSIS
EP3775278A1 (en) 2018-04-02 2021-02-17 Illumina Inc. Compositions and methods for making controls for sequence-based genetic testing
CA3096621A1 (en) 2018-04-09 2019-10-17 The Board Of Trustees Of The Leland Stanford Junior University Method of in situ gene sequencing
NL2020861B1 (en) 2018-04-12 2019-10-22 Illumina Inc Variant classifier based on deep neural networks
WO2019200338A1 (en) 2018-04-12 2019-10-17 Illumina, Inc. Variant classifier based on deep neural networks
CA3097583A1 (en) 2018-04-19 2019-10-24 Omniome, Inc. Improving accuracy of base calls in nucleic acid sequencing methods
BR112019028109A2 (pt) 2018-04-20 2020-07-28 Illumina, Inc. métodos de encapsular células individuais, as células encapsuladas e seus usos
US20210189460A1 (en) 2018-04-25 2021-06-24 Qiagen Sciences Llc Sequential paired-end sequencing
CA3098296A1 (en) 2018-04-26 2019-10-31 Omniome, Inc. Methods and compositions for stabilizing nucleic acid-nucleotide-polymerase complexes
AU2019271028B2 (en) 2018-05-14 2025-09-18 Bruker Spatial Biology, Inc. Chemical compositions and methods of using same
CN119684383A (zh) 2018-05-15 2025-03-25 伊鲁米纳公司 用于表面结合寡核苷酸的化学裂解和脱保护的组合物和方法
MX2019015013A (es) 2018-05-17 2021-01-08 Illumina Inc Secuenciación de células individuales de alto rendimiento con sesgo de amplificación reducido.
CN112534063A (zh) 2018-05-22 2021-03-19 安序源有限公司 用于核酸测序的方法、系统和组合物
EP3802880B1 (en) 2018-05-25 2024-10-23 Illumina, Inc. Circulating rna signatures specific to preeclampsia
US11821023B2 (en) 2018-05-30 2023-11-21 Generation Biotech, Llc Method for capturing long polynucleotides for sequencing specific gnomic regions
AU2019276719B2 (en) 2018-05-31 2025-11-13 Pacific Biosciences Of California, Inc. Increased signal to noise in nucleic acid sequencing
US11180794B2 (en) 2018-05-31 2021-11-23 Omniome, Inc. Methods and compositions for capping nucleic acids
DK3810774T3 (da) 2018-06-04 2023-12-11 Illumina Inc Enkeltcelletransskriptom-biblioteker med højt throughput og fremgangsmåder til fremstilling og anvendelse
US11391626B2 (en) 2018-06-22 2022-07-19 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
CN108822173B (zh) * 2018-06-26 2021-04-02 合肥华纳生物医药科技有限公司 一种荧光标记可剪切核苷酸、合成方法及其在dna测序中的用途
NL2021377B1 (en) 2018-07-03 2020-01-08 Illumina Inc Interposer with first and second adhesive layers
US12073922B2 (en) 2018-07-11 2024-08-27 Illumina, Inc. Deep learning-based framework for identifying sequence patterns that cause sequence-specific errors (SSEs)
EP3820943A1 (en) 2018-07-13 2021-05-19 Quantum-si Incorporated Biconjugatable labels and methods of use
JP7430701B2 (ja) 2018-07-23 2024-02-13 ディーエヌエー スクリプト 核酸鎖の大規模並列酵素合成
WO2020023362A1 (en) 2018-07-24 2020-01-30 Omniome, Inc. Serial formation of ternary complex species
WO2020022891A2 (en) 2018-07-26 2020-01-30 Stichting Vumc Biomarkers for atrial fibrillation
SG11202101934SA (en) 2018-07-30 2021-03-30 Readcoor Llc Methods and systems for sample processing or analysis
EP3830289A1 (en) 2018-08-03 2021-06-09 10X Genomics, Inc. Methods and systems to minimize barcode exchange
JP2021532815A (ja) 2018-08-07 2021-12-02 ザ・ブロード・インスティテュート・インコーポレイテッド 新規Cas12b酵素およびシステム
MX2021001709A (es) 2018-08-15 2021-05-27 Illumina Inc Composiciones y metodos para mejorar el enriquecimiento de genotecas.
US12098419B2 (en) 2018-08-23 2024-09-24 Ncan Genomics, Inc. Linked target capture and ligation
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
SG11202102003TA (en) 2018-08-28 2021-03-30 10X Genomics Inc Methods of generating an array
EP3844308A1 (en) 2018-08-28 2021-07-07 10X Genomics, Inc. Resolving spatial arrays
EP3850110A4 (en) 2018-09-11 2022-06-08 Singular Genomics Systems, Inc. MODIFIED ARCHAEAL POLYMERASES OF THE B FAMILY
EP3853358A1 (en) 2018-09-17 2021-07-28 Omniome, Inc. Engineered polymerases for improved sequencing
KR20210047364A (ko) 2018-09-19 2021-04-29 앱톤 바이오시스템즈, 인코포레이티드 밀집 패킹된 분석물층 및 검출 방법
US12258368B2 (en) 2018-09-28 2025-03-25 Centrillion Technology Holdings Corporation Disulfide-linked reversible terminators
WO2020072816A1 (en) 2018-10-03 2020-04-09 The Broad Institute, Inc. Crispr effector system based diagnostics for hemorrhagic fever detection
CN119432989A (zh) * 2018-10-11 2025-02-14 青岛华大智造科技有限责任公司 对多核苷酸进行测序的方法
AU2019272062B2 (en) 2018-10-15 2021-08-19 Illumina, Inc. Deep learning-based techniques for pre-training deep convolutional neural networks
US12145960B2 (en) 2018-10-25 2024-11-19 Singular Genomics Systems, Inc. Nucleotide analogues
EP4656734A2 (en) 2018-10-26 2025-12-03 Illumina, Inc. Modulating polymer beads for dna processing
CA3103719A1 (en) 2018-10-31 2020-05-07 Illumina, Inc. Polymerases, compositions, and methods of use
AU2019379287A1 (en) 2018-11-14 2021-06-03 Dna Script Terminal deoxynucleotidyl transferase variants and uses thereof
US20240011086A1 (en) 2018-11-15 2024-01-11 Omniome, Inc. Electronic detection of nucleic acid structure
NL2022043B1 (en) 2018-11-21 2020-06-03 Akershus Univ Hf Tagmentation-Associated Multiplex PCR Enrichment Sequencing
MX2021003771A (es) 2018-11-30 2021-05-27 Illumina Inc Analisis de analitos multiples usando un ensayo unico.
GB2585608B (en) 2018-12-04 2021-11-03 Omniome Inc Mixed-phase fluids for nucleic acid sequencing and other analytical assays
EP3891305A1 (en) 2018-12-05 2021-10-13 Illumina Cambridge Limited Methods and compositions for cluster generation by bridge amplification
IL279423B (en) 2018-12-05 2022-08-01 Illumina Inc Polymerases, preparations and methods of use
US12385083B2 (en) 2018-12-10 2025-08-12 10X Genomics, Inc. Methods of using master / copy arrays for spatial detection
KR20210104779A (ko) 2018-12-13 2021-08-25 디엔에이 스크립트 세포 및 생체분자 상의 직접 올리고뉴클레오타이드 합성
GB201820341D0 (en) 2018-12-13 2019-01-30 10X Genomics Inc Method for transposase-mediated spatial tagging and analysing genomic DNA in a biological specimen
GB201820300D0 (en) 2018-12-13 2019-01-30 10X Genomics Inc Method for spatial tagging and analysing genomic DNA in a biological specimen
ES2973302T3 (es) 2018-12-14 2024-06-19 Illumina Cambridge Ltd Disminución del ajuste de fase con nucleótidos sin marcar durante la secuenciación
CA3103744A1 (en) 2018-12-17 2020-06-25 Pietro GATTI-LAFRANCONI Compositions for use in polynucleotide sequencing
CA3103750A1 (en) 2018-12-17 2020-06-25 Illumina Cambridge Limited Primer oligonucleotide for sequencing
JP7587425B2 (ja) 2018-12-18 2024-11-20 イルミナ ケンブリッジ リミテッド 単一表面プライマーを使用したペアエンドシーケンシングのための方法および組成物
EP3899037B1 (en) 2018-12-19 2023-10-18 Illumina, Inc. Methods for improving polynucleotide cluster clonality priority
EP3899032A2 (en) 2018-12-20 2021-10-27 Omniome, Inc. Temperature control for analysis of nucleic acids and other analytes
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US11152128B2 (en) 2019-01-02 2021-10-19 Radiaction Ltd Radiation protection apparatus and materials therefor
ES3031116T3 (en) 2019-01-02 2025-07-04 Radiaction Ltd Patient head protection device
EP3884071B1 (en) 2019-01-03 2025-03-26 Ncan Genomics, Inc. Linked target capture
US12428668B2 (en) 2019-01-03 2025-09-30 Dna Script One pot synthesis of sets of oligonucleotides
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US10822653B1 (en) 2019-01-08 2020-11-03 Singular Genomics Systems, Inc. Nucleotide cleavable linkers and uses thereof
WO2020144373A1 (en) 2019-01-11 2020-07-16 Illumina Cambridge Limited Complex surface-bound transposome complexes
CN113614097A (zh) 2019-01-23 2021-11-05 宽腾矽公司 高强度标记的反应物组合物和测序方法
EP3921418A4 (en) 2019-02-06 2023-02-08 Singular Genomics Systems, Inc. Compositions and methods for nucleic acid sequencing
IL285364B2 (en) 2019-02-12 2025-01-01 Dna Script An efficient cleavage product in template-free enzymatic synthesis of polynucleotides
US11499189B2 (en) 2019-02-14 2022-11-15 Pacific Biosciences Of California, Inc. Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes
CN119662792A (zh) 2019-02-19 2025-03-21 阿尔缇玛基因组学公司 用于光学检测和测序的接头和方法
CN113613787B (zh) 2019-02-20 2023-06-13 加利福尼亚太平洋生物科学股份有限公司 用于检测化学和生物分析物的扫描装置和方法
EP3931354A1 (en) 2019-02-28 2022-01-05 10X Genomics, Inc. Profiling of biological analytes with spatially barcoded oligonucleotide arrays
JP7637390B2 (ja) 2019-03-01 2025-02-28 イルミナ インコーポレイテッド ハイスループット単一核及び単一細胞ライブラリー、並びに製造及び使用方法
WO2020190509A1 (en) 2019-03-15 2020-09-24 10X Genomics, Inc. Methods for using spatial arrays for single cell sequencing
NL2023316B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based sequencing
WO2020191390A2 (en) 2019-03-21 2020-09-24 Illumina, Inc. Artificial intelligence-based quality scoring
US11783917B2 (en) 2019-03-21 2023-10-10 Illumina, Inc. Artificial intelligence-based base calling
NL2023311B9 (en) 2019-03-21 2021-03-12 Illumina Inc Artificial intelligence-based generation of sequencing metadata
NL2023314B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based quality scoring
NL2023310B1 (en) 2019-03-21 2020-09-28 Illumina Inc Training data generation for artificial intelligence-based sequencing
NL2023312B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based base calling
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
WO2020198071A1 (en) 2019-03-22 2020-10-01 10X Genomics, Inc. Three-dimensional spatial analysis
US11609208B2 (en) 2019-04-12 2023-03-21 Western Digital Technologies, Inc. Devices and methods for molecule detection based on thermal stabilities of magnetic nanoparticles
US11579217B2 (en) 2019-04-12 2023-02-14 Western Digital Technologies, Inc. Devices and methods for frequency- and phase-based detection of magnetically-labeled molecules using spin torque oscillator (STO) sensors
US11112468B2 (en) 2019-04-12 2021-09-07 Western Digital Technologies, Inc. Magnetoresistive sensor array for molecule detection and related detection schemes
EP3941625A1 (en) 2019-04-12 2022-01-26 Western Digital Technologies Inc. Nucleic acid sequencing by synthesis using magnetic sensor arrays
US11738336B2 (en) 2019-04-12 2023-08-29 Western Digital Technologies, Inc. Spin torque oscillator (STO) sensors used in nucleic acid sequencing arrays and detection schemes for nucleic acid sequencing
US11327073B2 (en) 2019-04-12 2022-05-10 Western Digital Technologies, Inc. Thermal sensor array for molecule detection and related detection schemes
US11423306B2 (en) 2019-05-16 2022-08-23 Illumina, Inc. Systems and devices for characterization and performance analysis of pixel-based sequencing
US11593649B2 (en) 2019-05-16 2023-02-28 Illumina, Inc. Base calling using convolutions
EP3976820A1 (en) 2019-05-30 2022-04-06 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2020252186A1 (en) 2019-06-11 2020-12-17 Omniome, Inc. Calibrated focus sensing
CN121003454A (zh) 2019-07-02 2025-11-25 瑞迪艾森有限公司 可展开辐射防护屏罩
SG11202105834UA (en) 2019-07-12 2021-07-29 Illumina Cambridge Ltd Nucleic acid library preparation using electrophoresis
CA3125241A1 (en) 2019-07-12 2021-01-21 Illumina Cambridge Limited Compositions and methods for preparing nucleic acid sequencing libraries using crispr/cas9 immobilized on a solid support
WO2021011803A1 (en) 2019-07-16 2021-01-21 Omniome, Inc. Synthetic nucleic acids having non-natural structures
US10656368B1 (en) 2019-07-24 2020-05-19 Omniome, Inc. Method and system for biological imaging using a wide field objective lens
JP2022543569A (ja) 2019-07-30 2022-10-13 ディーエヌエー スクリプト ポリ(a)およびポリ(u)ポリメラーゼを使用するポリヌクレオチドの鋳型なしの酵素による合成
CN114430778B (zh) 2019-08-01 2024-07-05 Dna斯克瑞普特公司 增加多核苷酸的无模板酶促合成中长序列的产量
US20230242979A1 (en) * 2019-08-20 2023-08-03 Egi Tech (Shen Zhen) Co., Limited Method for sequencing polynucleotides based on optical signal kinetics of luminescent labels and secondary luminescent signals
JP2022547918A (ja) 2019-09-09 2022-11-16 ディーエヌエー スクリプト 光開裂性結合を用いる鋳型なし酵素的ポリヌクレオチド合成
TW202124406A (zh) 2019-09-10 2021-07-01 美商歐姆尼歐美公司 核苷酸之可逆修飾
US20220290245A1 (en) 2019-09-11 2022-09-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Cancer detection and classification
US11512295B2 (en) 2019-09-12 2022-11-29 Singular Genomics Systems, Inc. Modified thermoccocus polymerases
US11208682B2 (en) 2019-09-13 2021-12-28 Western Digital Technologies, Inc. Enhanced optical detection for nucleic acid sequencing using thermally-dependent fluorophore tags
CA3151411A1 (en) 2019-09-23 2021-04-01 Adrian Horgan Increasing long-sequence yields in template-free enzymatic synthesis of polynucleotides
US11287422B2 (en) 2019-09-23 2022-03-29 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
CN117036248A (zh) 2019-10-01 2023-11-10 10X基因组学有限公司 用于识别组织样品中的形态学模式的系统和方法
EP4513431A3 (en) * 2019-10-18 2025-03-26 The Board of Trustees of the Leland Stanford Junior University Clinical- and industrial-scale intact-tissue sequencing
CN114599795A (zh) 2019-10-18 2022-06-07 加利福尼亚太平洋生物科学股份有限公司 用于对核酸加帽的方法和组合物
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
EP4055155A1 (en) 2019-11-08 2022-09-14 Pacific Biosciences of California, Inc. Engineered polymerases for improved sequencing by binding
WO2021091611A1 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
CN114761575A (zh) 2019-11-13 2022-07-15 Dna斯克瑞普特公司 多核苷酸的高效无模板酶促合成
EP4062316B1 (en) 2019-11-18 2025-12-31 10X Genomics, Inc. TISSUE CLASSIFICATION SYSTEMS AND METHODS
EP4062373B1 (en) 2019-11-21 2025-01-22 10X Genomics, Inc. Spatial analysis of analytes
AU2020387423A1 (en) 2019-11-22 2021-09-30 Illumina, Inc. Circulating RNA signatures specific to preeclampsia
US11747329B2 (en) 2019-11-22 2023-09-05 Western Digital Technologies, Inc. Magnetic gradient concentrator/reluctance detector for molecule detection
DE202019106695U1 (de) 2019-12-02 2020-03-19 Omniome, Inc. System zur Sequenzierung von Nukleinsäuren in Fluidschaum
DE202019106694U1 (de) 2019-12-02 2020-03-19 Omniome, Inc. System zur Sequenzierung von Nukleinsäuren in Fluidschaum
CA3131632A1 (en) 2019-12-04 2021-06-10 Tong Liu Preparation of dna sequencing libraries for detection of dna pathogens in plasma
WO2021118349A1 (en) 2019-12-10 2021-06-17 Prinses Máxima Centrum Voor Kinderoncologie B.V. Methods of typing germ cell tumors
CA3161087A1 (en) 2019-12-12 2021-06-17 Dna Script Chimeric terminal deoxynucleotidyl transferases for template-free enzymatic synthesis of polynucleotides
CN115135770A (zh) 2019-12-16 2022-09-30 Dna斯克瑞普特公司 使用无歧化作用末端脱氧核苷酸转移酶变体的多核苷酸无模板酶学合成
EP4077344B1 (en) * 2019-12-18 2025-07-23 F. Hoffmann-La Roche AG Methods of sequencing by synthesis using a consecutive labeling scheme
CN114008199A (zh) 2019-12-19 2022-02-01 伊路敏纳公司 高通量单细胞文库及其制备和使用方法
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
US11498078B2 (en) 2019-12-23 2022-11-15 Singular Genomics Systems, Inc. Flow cell receiver and methods of use
US11747262B2 (en) 2019-12-23 2023-09-05 Singular Genomics Systems, Inc. Flow cell carrier and methods of use
ES2946357T3 (es) 2019-12-23 2023-07-17 10X Genomics Inc Métodos para el análisis espacial usando ligación con molde de ARN
AU2020412459B2 (en) 2019-12-23 2022-12-08 Singular Genomics Systems, Inc. Methods for long read sequencing
WO2021133842A1 (en) 2019-12-23 2021-07-01 10X Genomics, Inc. Compositions and methods for using fixed biological samples in partition-based assays
CN115667507A (zh) 2019-12-31 2023-01-31 奇异基因组学系统公司 用于长读出测序的多核苷酸条形码
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
WO2021155063A1 (en) 2020-01-29 2021-08-05 Readcoor, Llc Compositions and methods for analyte detection
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US12110548B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Bi-directional in situ analysis
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
EP4100161B1 (en) 2020-02-04 2024-07-10 Pacific Biosciences of California, Inc. Flow cells and methods for their use
US12112833B2 (en) 2020-02-04 2024-10-08 10X Genomics, Inc. Systems and methods for index hopping filtering
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US12129516B2 (en) 2020-02-07 2024-10-29 10X Genomics, Inc. Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US12421558B2 (en) 2020-02-13 2025-09-23 10X Genomics, Inc. Systems and methods for joint interactive visualization of gene expression and DNA chromatin accessibility
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
US12399123B1 (en) 2020-02-14 2025-08-26 10X Genomics, Inc. Spatial targeting of analytes
EP4107284A1 (en) 2020-02-17 2022-12-28 10X Genomics, Inc. In situ analysis of chromatin interaction
US11807851B1 (en) 2020-02-18 2023-11-07 Ultima Genomics, Inc. Modified polynucleotides and uses thereof
WO2021168353A2 (en) 2020-02-20 2021-08-26 Illumina, Inc. Artificial intelligence-based many-to-many base calling
US20210265016A1 (en) 2020-02-20 2021-08-26 Illumina, Inc. Data Compression for Artificial Intelligence-Based Base Calling
US20210265015A1 (en) 2020-02-20 2021-08-26 Illumina, Inc. Hardware Execution and Acceleration of Artificial Intelligence-Based Base Caller
US12354008B2 (en) 2020-02-20 2025-07-08 Illumina, Inc. Knowledge distillation and gradient pruning-based compression of artificial intelligence-based base caller
AU2021224860A1 (en) 2020-02-21 2022-09-15 10X Genomics, Inc. Compositions, methods and systems for sample processing
CN115698324A (zh) 2020-02-21 2023-02-03 10X基因组学有限公司 用于整合原位空间测定的方法和组合物
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
CN115151652B (zh) 2020-02-25 2025-02-07 Dna斯克瑞普特公司 用于酶促合成多核苷酸的方法和设备
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11034942B1 (en) 2020-02-27 2021-06-15 Singular Genomics Systems, Inc. Modified pyrococcus polymerases and uses thereof
CN115516104A (zh) 2020-03-03 2022-12-23 加利福尼亚太平洋生物科学股份有限公司 用于对双链核酸进行测序的方法和组合物
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
US12188085B2 (en) 2020-03-05 2025-01-07 10X Genomics, Inc. Three-dimensional spatial transcriptomics with sequencing readout
WO2021178893A2 (en) 2020-03-06 2021-09-10 Singular Genomics Systems, Inc. Linked paired strand sequencing
CN115297964A (zh) 2020-03-10 2022-11-04 西部数据技术公司 用于核酸定序的磁性传感器阵列以及制造及使用其的方法
AU2021249046A1 (en) 2020-03-30 2022-10-20 Illumina, Inc. Methods and compositions for preparing nucleic acid libraries
US20230159903A1 (en) 2020-04-20 2023-05-25 Dna Script Terminal Deoxynucleotidyl Transferase Variants and Uses Thereof
CN115551639B (zh) * 2020-04-21 2025-05-02 赫孚孟拉罗股份公司 具有单分子传感器阵列的高通量核酸定序
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
EP4117682B1 (en) 2020-04-24 2025-06-04 Singular Genomics Systems, Inc. Modified nucleotides and uses thereof
EP4143344A1 (en) 2020-04-27 2023-03-08 Agendia N.V. Treatment of her2 negative, mammaprint high risk 2 breast cancer
WO2021224677A1 (en) 2020-05-05 2021-11-11 Akershus Universitetssykehus Hf Compositions and methods for characterizing bowel cancer
WO2021225886A1 (en) 2020-05-05 2021-11-11 Omniome, Inc. Compositions and methods for modifying polymerase-nucleic acid complexes
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
KR20230009878A (ko) 2020-05-08 2023-01-17 일루미나, 인코포레이티드 게놈 서열분석 및 검출 기술
CA3177286A1 (en) 2020-05-12 2021-11-18 Illumina Inc. Generating nucleic acids with modified bases using recombinant terminal deoxynucleotidyl transferase
EP4153984A1 (en) 2020-05-19 2023-03-29 10X Genomics, Inc. Electrophoresis cassettes and instrumentation
EP4553168A3 (en) 2020-05-22 2025-08-27 10x Genomics, Inc. Spatial analysis to detect sequence variants
EP4153775B1 (en) 2020-05-22 2024-07-24 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
US12265079B1 (en) 2020-06-02 2025-04-01 10X Genomics, Inc. Systems and methods for detecting analytes from captured single biological particles
CN116249785A (zh) 2020-06-02 2023-06-09 10X基因组学有限公司 用于抗原-受体的空间转录组学
WO2021247543A2 (en) 2020-06-02 2021-12-09 10X Genomics, Inc. Nucleic acid library methods
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
EP4162075A4 (en) 2020-06-08 2024-06-26 The Broad Institute, Inc. Single cell combinatorial indexing from amplified nucleic acids
WO2021252617A1 (en) 2020-06-09 2021-12-16 Illumina, Inc. Methods for increasing yield of sequencing libraries
EP4164796A4 (en) 2020-06-10 2024-03-06 10x Genomics, Inc. Fluid delivery methods
US12435363B1 (en) 2020-06-10 2025-10-07 10X Genomics, Inc. Materials and methods for spatial transcriptomics
EP4446430A3 (en) 2020-06-10 2024-12-18 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
EP4231174A3 (en) 2020-06-11 2023-11-01 Nautilus Subsidiary, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
US12209273B2 (en) 2020-06-12 2025-01-28 10X Genomics, Inc. Nucleic acid assays using click chemistry bioconjugation
JP2023531620A (ja) 2020-06-16 2023-07-25 ディーエヌエー スクリプト 酵素的ポリヌクレオチド合成のためのシステム、装置及びキット
US11787831B2 (en) 2020-06-22 2023-10-17 Illumina Cambridge Limited Nucleosides and nucleotides with 3′ acetal blocking group
CN116034166A (zh) 2020-06-25 2023-04-28 10X基因组学有限公司 Dna甲基化的空间分析
AU2021299216A1 (en) 2020-06-30 2022-12-08 Illumina, Inc. Catalytically controlled sequencing by synthesis to produce scarless DNA
KR20230035253A (ko) 2020-07-02 2023-03-13 일루미나, 인코포레이티드 플로우 셀에서 핵산 라이브러리 시딩 효율을 보정하는 방법
US12168801B1 (en) 2020-07-02 2024-12-17 10X Genomics, Inc. Hybrid/capture probe designs for full-length cDNA
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
CN116018412A (zh) 2020-07-08 2023-04-25 Illumina公司 作为转座体载体的小珠
WO2022015600A2 (en) 2020-07-13 2022-01-20 Singular Genomics Systems, Inc. Methods of sequencing complementary polynucleotides
WO2022013094A1 (en) 2020-07-15 2022-01-20 Dna Script Massively parallel enzymatic synthesis of polynucleotides
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
JP2023543541A (ja) 2020-08-06 2023-10-17 イルミナ インコーポレイテッド ビーズ連結トランスポソームを使用するrna及びdna配列決定ライブラリの調製
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
US12297499B2 (en) 2020-08-17 2025-05-13 10X Genomics, Inc. Multicomponent nucleic acid probes for sample analysis
EP4200416A1 (en) 2020-08-18 2023-06-28 Illumina, Inc. Sequence-specific targeted transposition and selection and sorting of nucleic acids
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
US20220067489A1 (en) 2020-08-28 2022-03-03 Illumina, Inc. Detecting and Filtering Clusters Based on Artificial Intelligence-Predicted Base Calls
US11200446B1 (en) 2020-08-31 2021-12-14 Element Biosciences, Inc. Single-pass primary analysis
US12469162B2 (en) 2020-08-31 2025-11-11 Element Biosciences, Inc. Primary analysis in next generation sequencing
EP4211261B1 (en) 2020-09-11 2024-11-20 Illumina Cambridge Limited Methods of enriching a target sequence from a sequencing library using hairpin adaptors
WO2022056385A1 (en) 2020-09-14 2022-03-17 Singular Genomics Systems, Inc. Methods and systems for multidimensional imaging
CN116194590A (zh) 2020-09-18 2023-05-30 10X基因组学有限公司 样品处理设备和图像配准方法
CA3193386A1 (en) 2020-09-22 2022-03-31 Mikhael SOSKINE Stabilized n-terminally truncated terminal deoxynucleotidyl transferase variants and uses thereof
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
MX2023004461A (es) 2020-10-21 2023-05-03 Illumina Inc Plantillas de secuenciacion que comprenden multiples insertos y composiciones y metodos para mejorar la productividad de secuenciacion.
WO2022087485A1 (en) 2020-10-22 2022-04-28 Singular Genomics Systems, Inc. Nucleic acid circularization and amplification on a surface
EP4237573A1 (en) 2020-10-29 2023-09-06 DNA Script Enzymatic synthesis of polynucleotide probes
US12031179B2 (en) 2020-10-30 2024-07-09 Singular Genomics Systems, Inc. Methods and compositions for reducing nucleotide impurities
US12071667B2 (en) 2020-11-04 2024-08-27 10X Genomics, Inc. Sequence analysis using meta-stable nucleic acid molecules
US12391970B2 (en) 2020-11-11 2025-08-19 Microsoft Technology Licensing, Llc Spatial control of polynucleotide synthesis by strand capping
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
WO2022118862A1 (ja) * 2020-12-01 2022-06-09 国立大学法人九州大学 生体分子構造検出用プローブ、生体分子構造検出用キット、及び生体分子構造の検出方法
US20220170010A1 (en) 2020-12-02 2022-06-02 Illumina Software, Inc. System and method for detection of genetic alterations
EP4012046A1 (en) 2020-12-11 2022-06-15 10X Genomics, Inc. Methods and compositions for multimodal in situ analysis
EP4264231A4 (en) 2020-12-16 2024-11-13 Singular Genomics Systems, Inc. Kinematic imaging system
CA3205944C (en) 2020-12-21 2025-02-11 Singular Genomics Systems, Inc. MULTICOLOR IMAGING SYSTEMS AND METHODS
AU2021409136A1 (en) 2020-12-21 2023-06-29 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
AU2022208683A1 (en) 2021-01-13 2023-08-03 Pacific Biosciences Of California, Inc. Surface structuring with colloidal assembly
US12060603B2 (en) 2021-01-19 2024-08-13 10X Genomics, Inc. Methods for internally controlled in situ assays using padlock probes
WO2022164809A1 (en) 2021-01-26 2022-08-04 10X Genomics, Inc. Nucleic acid analog probes for in situ analysis
CA3206511A1 (en) 2021-01-29 2022-08-04 Yir-Shyuan WU Methods, compositions and kits to improve seeding efficiency of flow cells with polynucleotides
CN116829731A (zh) 2021-02-04 2023-09-29 Illumina公司 转座体结合珠粒上的长带索引连接的读段生成
US11486001B2 (en) 2021-02-08 2022-11-01 Singular Genomics Systems, Inc. Methods and compositions for sequencing complementary polynucleotides
US20240043915A1 (en) 2021-02-13 2024-02-08 The General Hospital Corporation Methods and compositions for in situ macromolecule detection and uses thereof
WO2022178267A2 (en) 2021-02-19 2022-08-25 10X Genomics, Inc. Modular assay support devices
US12275984B2 (en) 2021-03-02 2025-04-15 10X Genomics, Inc. Sequential hybridization and quenching
EP4301873A1 (en) 2021-03-03 2024-01-10 10X Genomics, Inc. Analyte detection in situ using nucleic acid origami
US11884977B2 (en) 2021-03-12 2024-01-30 Singular Genomics Systems, Inc. Nanoarrays and methods of use thereof
WO2022192671A1 (en) 2021-03-12 2022-09-15 Singular Genomics Systems, Inc. Nanoarrays and methods of use thereof
WO2022197754A1 (en) 2021-03-16 2022-09-22 Illumina Software, Inc. Neural network parameter quantization for base calling
EP4301870B1 (en) 2021-03-18 2025-01-15 10X Genomics, Inc. Multiplex capture of gene and protein expression from a biological sample
AU2022245985A1 (en) 2021-03-22 2023-09-21 Illumina Cambridge Limited Methods for improving nucleic acid cluster clonality
WO2022212280A1 (en) 2021-03-29 2022-10-06 Illumina, Inc. Compositions and methods for assessing dna damage in a library and normalizing amplicon size bias
MX2023010814A (es) 2021-03-29 2023-09-27 Illumina Inc Metodos mejorados de preparacion de genotecas.
EP4314282A1 (en) 2021-03-30 2024-02-07 Illumina, Inc. Improved methods of isothermal complementary dna and library preparation
EP4314283A1 (en) 2021-03-31 2024-02-07 Illumina, Inc. Methods of preparing directional tagmentation sequencing libraries using transposon-based technology with unique molecular identifiers for error correction
JP2024512122A (ja) 2021-03-31 2024-03-18 イルミナ・ケンブリッジ・リミテッド アダプター二量体検出を用いる核酸ライブラリシーケンシング技術
CA3183578A1 (en) 2021-03-31 2022-10-06 Illumina Inc. Artificial intelligence-based base caller with contextual awareness
DE102022107811A1 (de) 2021-04-02 2022-10-06 Dna Script Methoden und kits für die enzymatische synthese von zu-g4-neigenden polynukleotiden
US20220319641A1 (en) 2021-04-02 2022-10-06 Illumina, Inc. Machine-learning model for detecting a bubble within a nucleotide-sample slide for sequencing
EP4428246B1 (en) 2021-04-14 2025-12-24 10X Genomics, Inc. Methods of measuring mislocalization of an analyte
US20220336057A1 (en) 2021-04-15 2022-10-20 Illumina, Inc. Efficient voxelization for deep learning
US12217829B2 (en) 2021-04-15 2025-02-04 Illumina, Inc. Artificial intelligence-based analysis of protein three-dimensional (3D) structures
FR3121936A1 (fr) 2021-04-20 2022-10-21 Naos Institute Of Life Science Methode de criblage d’ingredients et de compositions topiques ecobiologiques, et son utilisation pour realiser un soin cosmetique de restauration du microbiote cutane
US12070744B2 (en) 2021-04-22 2024-08-27 Illumina, Inc. Valve assemblies and related systems
EP4294920A4 (en) 2021-04-27 2025-01-22 Singular Genomics Systems, Inc. HIGH-DENSITY SEQUENCING AND MULTIPLEX PRIMING
CA3217131A1 (en) 2021-04-29 2022-11-03 Niall Anthony Gormley Amplification techniques for nucleic acid characterization
EP4334706A4 (en) 2021-05-05 2025-08-06 Singular Genomics Systems Inc MULTIOMICS ANALYSIS DEVICE AND METHODS OF USE THEREOF
WO2022236054A1 (en) 2021-05-06 2022-11-10 10X Genomics, Inc. Methods for increasing resolution of spatial analysis
EP4334475A1 (en) 2021-05-07 2024-03-13 Agendia N.V. Endocrine treatment of hormone receptor positive breast cancer typed as having a low risk of recurrence
US20220356515A1 (en) 2021-05-10 2022-11-10 Pacific Biosciences Of California, Inc. Dna amplification buffer replenishment during rolling circle amplification
WO2022240764A1 (en) 2021-05-10 2022-11-17 Pacific Biosciences Of California, Inc. Single-molecule seeding and amplification on a surface
JP2024519372A (ja) 2021-05-20 2024-05-10 イルミナ インコーポレイテッド 合成によって配列決定するための組成物及び方法
JP2024521196A (ja) 2021-05-28 2024-05-28 イルミナ インコーポレイテッド 核酸調製のためのオリゴ修飾ヌクレオチド類似体
US20220380838A1 (en) 2021-06-01 2022-12-01 10X Genomics, Inc. Methods and compositions for analyte detection and probe resolution
CN117751197A (zh) 2021-06-02 2024-03-22 10X基因组学有限公司 使用不对称可环化探针的样品分析
WO2022256503A1 (en) 2021-06-03 2022-12-08 10X Genomics, Inc. Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
US20220403450A1 (en) 2021-06-03 2022-12-22 Illumina Software, Inc. Systems and methods for sequencing nucleotides using two optical channels
EP4355476A1 (en) 2021-06-15 2024-04-24 Illumina, Inc. Hydrogel-free surface functionalization for sequencing
US11859241B2 (en) 2021-06-17 2024-01-02 Element Biosciences, Inc. Compositions and methods for pairwise sequencing
US11220707B1 (en) 2021-06-17 2022-01-11 Element Biosciences, Inc. Compositions and methods for pairwise sequencing
EP4355867A2 (en) 2021-06-18 2024-04-24 Element Biosciences, Inc. Engineered polymerases
EP4359555A1 (en) 2021-06-23 2024-05-01 Illumina, Inc. Compositions, methods, kits, cartridges, and systems for sequencing reagents
US20240287505A1 (en) 2021-06-24 2024-08-29 Illumina, Inc. Methods and compositions for combinatorial indexing of bead-based nucleic acids
CN117546245A (zh) 2021-06-29 2024-02-09 因美纳有限公司 用于生成基因组坐标的置信度分类的机器学习模型
KR20240027599A (ko) 2021-06-29 2024-03-04 일루미나, 인코포레이티드 올리고 서열을 사용하여 훈련된 자체-학습 염기 호출자
BR112023026615A2 (pt) 2021-06-29 2024-03-05 Illumina Inc Métrica de relação sinal-ruído para determinar chamadas de bases de nucleotídeos e qualidade de chamadas de bases
WO2023278184A1 (en) 2021-06-29 2023-01-05 Illumina, Inc. Methods and systems to correct crosstalk in illumination emitted from reaction sites
US20230005253A1 (en) 2021-07-01 2023-01-05 Illumina, Inc. Efficient artificial intelligence-based base calling of index sequences
WO2023287617A1 (en) 2021-07-13 2023-01-19 Illumina, Inc. Methods and systems for real time extraction of crosstalk in illumination emitted from reaction sites
WO2023288225A1 (en) 2021-07-13 2023-01-19 10X Genomics, Inc. Methods for preparing polymerized matrix with controllable thickness
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
WO2023003757A1 (en) 2021-07-19 2023-01-26 Illumina Software, Inc. Intensity extraction with interpolation and adaptation for base calling
EP4373958A1 (en) 2021-07-23 2024-05-29 Illumina, Inc. Methods for preparing substrate surface for dna sequencing
US20230021577A1 (en) 2021-07-23 2023-01-26 Illumina Software, Inc. Machine-learning model for recalibrating nucleotide-base calls
KR20240037882A (ko) 2021-07-28 2024-03-22 일루미나, 인코포레이티드 염기 호출 시스템의 품질 점수 보정
US12139751B2 (en) 2021-07-30 2024-11-12 10X Genomics, Inc. Circularizable probes for in situ analysis
ES2988400T3 (es) 2021-07-30 2024-11-20 10X Genomics Inc Métodos y composiciones para sincronizar reacciones in situ
KR20240035413A (ko) 2021-08-03 2024-03-15 일루미나, 인코포레이티드 다중 염기 호출자 모델을 사용한 염기 호출
US12391984B2 (en) 2021-08-03 2025-08-19 10X Genomics, Inc. Compositions and methods for rolling circle amplification
CN118043476A (zh) 2021-08-03 2024-05-14 10X基因组学有限公司 核酸多联体及其稳定和/或压缩方法
US12460251B2 (en) 2021-08-03 2025-11-04 10X Genomics, Inc. Stabilization and/or compaction of nucleic acid molecules
US12077789B2 (en) 2021-08-14 2024-09-03 Illumina, Inc. Polymerases, compositions, and methods of use
EP4326898B1 (en) 2021-08-16 2024-07-31 10X Genomics, Inc. Probes comprising a split barcode region and methods of use
AU2022331421A1 (en) 2021-08-17 2024-01-04 Illumina, Inc. Methods and compositions for identifying methylated cytosines
WO2023023638A1 (en) 2021-08-20 2023-02-23 Singular Genomics Systems, Inc. Chemical and thermal assisted nucleic acid amplification methods
WO2023034076A1 (en) 2021-08-31 2023-03-09 Illumina, Inc. Flow cell with enhanced well imaging resolution
EP4509614A3 (en) 2021-09-01 2025-05-14 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
JP2024534741A (ja) 2021-09-01 2024-09-26 イルミナ インコーポレイテッド 加速した塩基呼び出しのための振幅変調
WO2023034920A2 (en) 2021-09-03 2023-03-09 Singular Genomics Systems, Inc. Amplification oligonucleotides
WO2023044229A1 (en) 2021-09-17 2023-03-23 Illumina, Inc. Automatically identifying failure sources in nucleotide sequencing from base-call-error patterns
JP2024535664A (ja) 2021-09-21 2024-10-02 イルミナ インコーポレイテッド 帰属ハプロタイプを用いたグラフ参照ゲノム及び塩基コールアプローチ
WO2023049215A1 (en) 2021-09-22 2023-03-30 Illumina, Inc. Compressed state-based base calling
CN118318049A (zh) 2021-09-28 2024-07-09 安序源有限公司 用于处理核酸样品的方法以及核酸样品的组合物
US12480157B2 (en) 2021-09-30 2025-11-25 Illumina, Inc. Polynucleotide sequencing
WO2023056328A2 (en) 2021-09-30 2023-04-06 Illumina, Inc. Solid supports and methods for depleting and/or enriching library fragments prepared from biosamples
KR20240074839A (ko) 2021-10-11 2024-05-28 노틸러스 서브시디어리, 인크. 단백질 및 프로테옴의 고도로 다중화 가능한 분석
WO2023069927A1 (en) 2021-10-20 2023-04-27 Illumina, Inc. Methods for capturing library dna for sequencing
US20250034623A1 (en) 2021-10-25 2025-01-30 Singular Genomics Systems, Inc. Manipulating and detecting biological samples
WO2023076833A1 (en) 2021-10-26 2023-05-04 Singular Genomics Systems, Inc. Multiplexed targeted amplification of polynucleotides
WO2023081485A1 (en) 2021-11-08 2023-05-11 Pacific Biosciences Of California, Inc. Stepwise sequencing of a polynucleotide with a homogenous reaction mixture
CN118234853A (zh) 2021-11-10 2024-06-21 Dna斯克瑞普特公司 新型末端脱氧核苷酸
EP4419707A1 (en) 2021-11-10 2024-08-28 10X Genomics, Inc. Methods, compositions, and kits for determining the location of an analyte in a biological sample
WO2023085932A1 (en) 2021-11-10 2023-05-19 Omnigen B.V. Prediction of response following folfirinox treatment in cancer patients
EP4430176A2 (en) 2021-11-10 2024-09-18 DNA Script Novel terminal deoxynucleotidyl transferase (tdt) variants
WO2023102118A2 (en) 2021-12-01 2023-06-08 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
WO2023102354A1 (en) 2021-12-02 2023-06-08 Illumina Software, Inc. Generating cluster-specific-signal corrections for determining nucleotide-base calls
US20230183799A1 (en) 2021-12-10 2023-06-15 Illumina, Inc. Parallel sample and index sequencing
EP4441711A1 (en) 2021-12-20 2024-10-09 10X Genomics, Inc. Self-test for pathology/histology slide imaging device
US20230193147A1 (en) 2021-12-21 2023-06-22 Illumina Cambridge Limited Wax-microsphere matrix compositions and methods of making and using the same
WO2023122363A1 (en) 2021-12-23 2023-06-29 Illumina Software, Inc. Dynamic graphical status summaries for nucelotide sequencing
EP4453524A4 (en) 2021-12-23 2025-12-17 Illumina Inc SYSTEMS AND ASSOCIATED TEMPERATURE CALIBRATION PROCEDURES
US20230215515A1 (en) 2021-12-23 2023-07-06 Illumina Software, Inc. Facilitating secure execution of external workflows for genomic sequencing diagnostics
WO2023129898A2 (en) 2021-12-27 2023-07-06 10X Genomics, Inc. Methods and compositions for rolling circle amplification
US20230207050A1 (en) 2021-12-28 2023-06-29 Illumina Software, Inc. Machine learning model for recalibrating nucleotide base calls corresponding to target variants
WO2023126457A1 (en) 2021-12-29 2023-07-06 Illumina Cambridge Ltd. Methods of nucleic acid sequencing using surface-bound primers
KR20240131386A (ko) 2021-12-29 2024-08-30 일루미나, 인코포레이티드 유전체 분석 애플리케이션을 위한 변이 분석 모델 버전 자동 스위칭
EP4466373A1 (en) 2022-01-20 2024-11-27 Illumina, Inc. Methods of detecting methylcytosine and hydroxymethylcytosine by sequencing
WO2023141588A1 (en) 2022-01-21 2023-07-27 10X Genomics, Inc. Multiple readout signals for analyzing a sample
US20240254537A1 (en) 2022-02-23 2024-08-01 Insitro, Inc. Pooled optical screening and transcriptional measurements of cells comprising barcoded genetic perturbations
CA3224595A1 (en) 2022-02-25 2023-08-31 Steven Norberg Machine-learning models for detecting and adjusting values for nucleotide methylation levels
WO2023164660A1 (en) 2022-02-25 2023-08-31 Illumina, Inc. Calibration sequences for nucelotide sequencing
CN118974836A (zh) 2022-03-08 2024-11-15 10X基因组学有限公司 将光学拥挤最小化的原位代码设计方法
US20250188521A1 (en) 2022-03-10 2025-06-12 Singular Genomics Systems, Inc. Nucleic acid delivery scaffolds
WO2023175041A1 (en) 2022-03-15 2023-09-21 Illumina, Inc. Concurrent sequencing of forward and reverse complement strands on concatenated polynucleotides
WO2023183937A1 (en) 2022-03-25 2023-09-28 Illumina, Inc. Sequence-to-sequence base calling
EP4500157A1 (en) 2022-03-29 2025-02-05 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
AU2023243205A1 (en) 2022-04-01 2024-09-19 10X Genomics, Inc. Compositions and methods for targeted masking of autofluorescence
WO2023196526A1 (en) 2022-04-06 2023-10-12 10X Genomics, Inc. Methods for multiplex cell analysis
CA3223722A1 (en) 2022-04-07 2023-10-12 Illumina, Inc. Altered cytidine deaminases and methods of use
JP2025512974A (ja) 2022-04-08 2025-04-22 イルミナ インコーポレイテッド アプタマーダイナミックレンジ圧縮及び検出技法
WO2023212490A1 (en) 2022-04-25 2023-11-02 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
EP4515547A1 (en) 2022-04-26 2025-03-05 Illumina, Inc. Machine-learning models for selecting oligonucleotide probes for array technologies
WO2023209606A1 (en) 2022-04-29 2023-11-02 Illumina Cambridge Limited Methods and systems for encapsulating lyophilised microspheres
EP4519674A1 (en) 2022-05-06 2025-03-12 10X Genomics, Inc. Analysis of antigen and antigen receptor interactions
US20230368866A1 (en) 2022-05-10 2023-11-16 Illumina Software, Inc. Adaptive neural network for nucelotide sequencing
EP4522769A1 (en) 2022-05-11 2025-03-19 10X Genomics, Inc. Compositions and methods for in situ sequencing
US20250320487A1 (en) 2022-05-18 2025-10-16 Illumina, Inc. Preparation Of Size-Controlled Nucleic Acid Fragments
EP4526470A1 (en) 2022-05-19 2025-03-26 Agendia N.V. Prediction of response to immune therapy in breast cancer patients
WO2023224488A1 (en) 2022-05-19 2023-11-23 Agendia N.V. Dna repair signature and prediction of response following cancer therapy
WO2023235353A2 (en) 2022-06-03 2023-12-07 Illumina, Inc. Circulating rna biomarkers for preeclampsia
EP4540607A1 (en) 2022-06-17 2025-04-23 10X Genomics, Inc. Catalytic de-crosslinking of samples for in situ analysis
US20230420080A1 (en) 2022-06-24 2023-12-28 Illumina Software, Inc. Split-read alignment by intelligently identifying and scoring candidate split groups
KR20250028287A (ko) 2022-06-27 2025-02-28 일루미나, 인코포레이티드 구조 변이 그래프 게놈의 생성 및 구현
CN119422199A (zh) 2022-06-27 2025-02-11 因美纳有限公司 用于基因型推算模型的加速器
EP4544554A1 (en) 2022-06-27 2025-04-30 Illumina, Inc. Improved human leukocyte antigen (hla) genotyping
WO2024015962A1 (en) 2022-07-15 2024-01-18 Pacific Biosciences Of California, Inc. Blocked asymmetric hairpin adaptors
US20240038327A1 (en) 2022-07-26 2024-02-01 Illumina Software, Inc. Rapid single-cell multiomics processing using an executable file
CN119677856A (zh) 2022-08-12 2025-03-21 10X基因组学有限公司 Puma1聚合酶及其用途
CN119677873A (zh) 2022-08-16 2025-03-21 10X基因组学有限公司 Ap50聚合酶及其用途
US20250361558A1 (en) 2022-08-19 2025-11-27 Illumina, Inc. Third dna base pair site-specific dna detection
WO2024059655A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
EP4588051A1 (en) 2022-09-16 2025-07-23 Illumina, Inc. Cluster segmentation and conditional base calling
WO2024073516A1 (en) 2022-09-29 2024-04-04 Illumina, Inc. A target-variant-reference panel for imputing target variants
US20240120027A1 (en) 2022-09-30 2024-04-11 Illumina, Inc. Machine-learning model for refining structural variant calls
WO2024073047A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Cytidine deaminases and methods of use in mapping modified cytosine nucleotides
WO2024069581A1 (en) 2022-09-30 2024-04-04 Illumina Singapore Pte. Ltd. Helicase-cytidine deaminase complexes and methods of use
US20250388894A1 (en) 2022-09-30 2025-12-25 Illumina, Inc. Methods of using cpg binding proteins in mapping modified cytosine nucleotides
US20240141427A1 (en) 2022-09-30 2024-05-02 Illumina, Inc. Polymerases, compositions, and methods of use
JP2025534929A (ja) 2022-10-05 2025-10-22 イルミナ インコーポレイテッド 機械学習アーキテクチャを利用した複数の配列決定パイプラインからの変異コールの統合
WO2024077202A2 (en) 2022-10-06 2024-04-11 Illumina, Inc. Probes for improving environmental sample surveillance
EP4482987A2 (en) 2022-10-06 2025-01-01 Illumina, Inc. Probes for improving coronavirus sample surveillance
WO2024077152A1 (en) 2022-10-06 2024-04-11 Illumina, Inc. Probes for depleting abundant small noncoding rna
US20240127906A1 (en) 2022-10-11 2024-04-18 Illumina, Inc. Detecting and correcting methylation values from methylation sequencing assays
CN120129825A (zh) 2022-10-14 2025-06-10 10X基因组学有限公司 用于评估生物样品质量的方法、组合物和系统
EP4605542A1 (en) 2022-10-19 2025-08-27 DNA Script Methods and products for removal of uracil containing polynucleotides
US20240167081A1 (en) 2022-11-08 2024-05-23 10X Genomics,Inc. Immobilization methods and compositions for in situ detection
US20240158852A1 (en) 2022-11-16 2024-05-16 10X Genomics, Inc. Methods and compositions for assessing performance of in situ assays
US12372771B2 (en) 2022-11-18 2025-07-29 10X Genomics, Inc. Systems and methods for actively mitigating vibrations
EP4627113A1 (en) 2022-11-30 2025-10-08 Illumina, Inc. Chemoenzymatic correction of false positive uracil transformations
WO2024118791A1 (en) 2022-11-30 2024-06-06 Illumina, Inc. Accurately predicting variants from methylation sequencing data
WO2024121022A1 (en) 2022-12-05 2024-06-13 Dna Script Variants of poly(a) polymerase and uses thereof
WO2024129672A1 (en) 2022-12-12 2024-06-20 The Broad Institute, Inc. Trafficked rnas for assessment of cell-cell connectivity and neuroanatomy
EP4634400A1 (en) 2022-12-14 2025-10-22 Illumina, Inc. Systems and methods for capture and enrichment of clustered beads on flow cell substrates
EP4634404A1 (en) 2022-12-16 2025-10-22 10X Genomics, Inc. Methods and compositions for assessing performance
EP4634403A1 (en) 2022-12-16 2025-10-22 Illumina, Inc. Boranes on solid supports
EP4639552A1 (en) 2022-12-21 2025-10-29 Illumina, Inc. Context-dependent base calling
EP4638789A1 (en) 2022-12-21 2025-10-29 10X Genomics, Inc. Methods for tethering ribonucleic acids in biological samples
AU2023409219A1 (en) 2022-12-22 2024-10-03 Illumina, Inc. Palladium catalyst compositions and methods for sequencing by synthesis
EP4638795A1 (en) 2022-12-22 2025-10-29 Illumina, Inc. Transition-metal catalyst compositions and methods for sequencing by synthesis
AU2023419253A1 (en) 2022-12-27 2024-10-03 Illumina, Inc. Methods of sequencing using 3´ allyl blocked nucleotides
EP4642920A1 (en) 2022-12-31 2025-11-05 DNA Script Variable viscosity inks for inkjet delivery of enzyme reagents
WO2024148300A1 (en) 2023-01-06 2024-07-11 10X Genomics, Inc. Methods and compositions for in situ analysis of variant sequences
CN119301271A (zh) 2023-01-06 2025-01-10 因美纳有限公司 通过聚合酶减少尿嘧啶
US20240241110A1 (en) 2023-01-12 2024-07-18 Nautilus Subsidiary, Inc. Characterization of glycans and glycoconjugates
EP4652291A1 (en) 2023-01-16 2025-11-26 DNA Script Scarless template-free enzymatic synthesis of polynucleotides
WO2024153643A1 (en) 2023-01-16 2024-07-25 Dna Script Inkjet-assisted enzymatic nucleic acid synthesis
EP4655411A2 (en) 2023-01-26 2025-12-03 DNA Script Enzymatic synthesis of polynucleotide probes
US20240266003A1 (en) 2023-02-06 2024-08-08 Illumina, Inc. Determining and removing inter-cluster light interference
CA3259901A1 (en) 2023-02-17 2024-08-22 Illumina, Inc. Cell-free DNA signals used as biomarkers for preeclampsia
US20250369046A1 (en) 2023-03-10 2025-12-04 Illumina, Inc. Aptamer detection techniques
CA3257470A1 (en) 2023-03-30 2024-10-03 Illumina, Inc. NUCLEIC ACID COMPOSITIONS AND SEQUENCE METHODS
WO2024206848A1 (en) 2023-03-30 2024-10-03 Illumina, Inc. Tandem repeat genotyping
AU2024266370A1 (en) 2023-05-03 2025-01-16 Illumina, Inc. Machine learning model for recalibrating genotype calls from existing sequencing data files
US20240368678A1 (en) 2023-05-03 2024-11-07 10X Genomics, Inc. Methods and compositions for spatial assay
WO2024249200A1 (en) 2023-05-26 2024-12-05 Illumina, Inc. Methods for preserving methylation status during clustering
WO2024249591A1 (en) 2023-05-31 2024-12-05 Illumina, Inc. Methods for double-stranded sequencing by synthesis
US20240404624A1 (en) 2023-05-31 2024-12-05 Illumina, Inc. Structural variant alignment and variant calling by utilizing a structural-variant reference genome
WO2024249466A1 (en) 2023-05-31 2024-12-05 Illumina, Inc. False positive reduction by translesion polymerase repair
WO2024249973A2 (en) 2023-06-02 2024-12-05 Illumina, Inc. Linking human genes to clinical phenotypes using graph neural networks
WO2024254003A1 (en) 2023-06-05 2024-12-12 Illumina, Inc. Identification and mapping of methylation sites
WO2024256604A1 (en) 2023-06-15 2024-12-19 Dna Script Salt addition during enzymatic polynucleotide synthesis
US20250002960A1 (en) 2023-06-26 2025-01-02 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid extension
WO2025006565A1 (en) 2023-06-27 2025-01-02 Illumina, Inc. Variant calling with methylation-level estimation
WO2025006874A1 (en) 2023-06-30 2025-01-02 Illumina, Inc. Machine-learning model for recalibrating genotype calls corresponding to germline variants and somatic mosaic variants
AU2024311047A1 (en) 2023-06-30 2025-12-11 Illumina, Inc. Using flowcell spatial coordinates to link reads for improved genome analysis
WO2025003434A1 (en) 2023-06-30 2025-01-02 Dna Script Nucleic acid synthesis on reusable support
WO2025006460A1 (en) 2023-06-30 2025-01-02 Illumina, Inc. Systems and methods of sequencing polynucleotides with modified bases
WO2025006466A1 (en) 2023-06-30 2025-01-02 Illumina, Inc. Systems and methods of sequencing polynucleotides with four labeled nucleotides
WO2025006464A1 (en) 2023-06-30 2025-01-02 Illumina, Inc. Systems and methods of sequencing polynucleotides with alternative scatterplots
WO2025010160A1 (en) 2023-07-06 2025-01-09 Pacific Biosciences Of California, Inc. Methods and compositions for stabilizing concatemers
WO2025024672A1 (en) 2023-07-26 2025-01-30 Element Biosciences, Inc. Dna sequencing systems and use thereof
WO2025029831A1 (en) 2023-07-31 2025-02-06 10X Genomics, Inc. Methods and systems for targeted rna cleavage and target rna-primed rolling circle amplification
GB202312147D0 (en) 2023-08-08 2023-09-20 Syndex Bio Ltd Methylation method
WO2025049331A2 (en) 2023-08-31 2025-03-06 Illumina, Inc. Aptamer detection techniques
WO2025049720A2 (en) 2023-08-31 2025-03-06 Illumina, Inc. Aptamer dynamic range compression and detection techniques
WO2025054389A1 (en) 2023-09-07 2025-03-13 Illumina, Inc. Identification of methylated cytosine using landmarks
EP4520821A1 (en) 2023-09-08 2025-03-12 The Regents Of The University Of Michigan Microrna-derived rnas and polypeptides and uses thereof
WO2025059045A1 (en) 2023-09-12 2025-03-20 Illumina, Inc. Systems and methods for determining linkage of sequence reads on a flow cell
WO2025058517A1 (en) 2023-09-12 2025-03-20 Levels Diagnostics Holding B.V. Biomarkers for typing a sample of an individual for hepatocellular carcinoma.
WO2025059533A1 (en) 2023-09-13 2025-03-20 The Broad Institute, Inc. Crispr enzymes and systems
WO2025062341A1 (en) 2023-09-20 2025-03-27 Element Biosciences, Inc. Solid-state and configurable optical test targets and flow cell devices
WO2025061942A1 (en) 2023-09-20 2025-03-27 Illumina, Inc. Sequencing error identification and correction
WO2025061922A1 (en) 2023-09-20 2025-03-27 Illumina, Inc. Methods for sequencing
WO2025072793A1 (en) 2023-09-28 2025-04-03 Illumina, Inc. Altered cytidine deaminases and methods of use
WO2025072368A1 (en) 2023-09-28 2025-04-03 Illumina, Inc. Capture and selective release of biological material
WO2025072833A1 (en) 2023-09-29 2025-04-03 Illumina, Inc. Predicting insert lengths using primary analysis metrics
WO2025072870A1 (en) 2023-09-29 2025-04-03 Illumina, Inc. Tracking and modifying cluster location on nucleotide-sample slides in real time
WO2025081064A2 (en) 2023-10-11 2025-04-17 Illumina, Inc. Thermophilic deaminase and methods for identifying modified cytosine
WO2025088024A1 (en) 2023-10-24 2025-05-01 Dna Script Novel terminal deoxynucleotidyl transferase (tdt) variants and uses thereof
WO2025090883A1 (en) 2023-10-27 2025-05-01 Illumina, Inc. Detecting variants in nucleotide sequences based on haplotype diversity
WO2025106431A1 (en) 2023-11-17 2025-05-22 Illumina, Inc. Determining structural variants
WO2025106629A1 (en) 2023-11-17 2025-05-22 Illumina, Inc. Structural variant detection using spatially linked reads
WO2025111463A1 (en) 2023-11-22 2025-05-30 10X Genomics, Inc. Methods for processing ribonucleic acids in biological samples
WO2025117738A1 (en) 2023-11-28 2025-06-05 Illumina, Inc. Methods of improving unique molecular index ligation efficiency
EP4567128A1 (en) 2023-12-07 2025-06-11 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Improved method and means for spatial nucleic acid detection in-situ
WO2025123005A2 (en) 2023-12-07 2025-06-12 Illumina, Inc. Preparation and compositions of cot-1 nucleic acid
WO2025129074A2 (en) 2023-12-14 2025-06-19 Illumina, Inc. Indexing techniques for tagmented dna libraries
US20250201342A1 (en) 2023-12-15 2025-06-19 Illumina, Inc. Minimal residual disease (mrd) models for determining likelihoods or probabilities of a subject comprising cancer
US20250201346A1 (en) 2023-12-18 2025-06-19 Illumina, Inc. Using machine learning models for detecting minimum residual disease (mrd) in a subject
WO2025137222A1 (en) 2023-12-19 2025-06-26 Illumina, Inc. Methylation detection assay
US20250210137A1 (en) 2023-12-20 2025-06-26 Illumina, Inc. Directly determining signal-to-noise-ratio metrics for accelerated convergence in determining nucleotide-base calls and base-call quality
WO2025137268A1 (en) 2023-12-20 2025-06-26 Pacific Biosciences Of California, Inc. Methods and compositions for reducing gc bias
WO2025136105A1 (en) 2023-12-20 2025-06-26 Stichting Amsterdam UMC Intestinal tissue-adherent microbial signatures predictive of response to anti-tnf-alpha in crohn's disease
US20250207203A1 (en) 2023-12-20 2025-06-26 10X Genomics, Inc. In situ detection of copy number variations in biological samples
US20250210141A1 (en) 2023-12-21 2025-06-26 Illumina, Inc. Enhanced mapping and alignment of nucleotide reads utilizing an improved haplotype data structure with allele-variant differences
WO2025136717A1 (en) 2023-12-22 2025-06-26 Illumina, Inc. Improving mapping resolution using spatial information of sequenced reads
US20250215493A1 (en) 2023-12-28 2025-07-03 Illumina, Inc. Nucleotides with enzymatically cleavable 3'-o-glycoside blocking groups for sequencing
WO2025144626A1 (en) 2023-12-28 2025-07-03 Illumina, Inc. Sequencing with single-stranded binding proteins
WO2025160089A1 (en) 2024-01-26 2025-07-31 Illumina, Inc. Custom multigenome reference construction for improved sequencing analysis of genomic samples
WO2025174774A1 (en) 2024-02-12 2025-08-21 Illumina, Inc. Determining offline corrections for sequence specific errors caused by low complexity nucleotide sequences
WO2025174708A1 (en) 2024-02-13 2025-08-21 Illumina, Inc. Design and method for cross-sequencing platform compatibility of flow cells
WO2025178951A1 (en) 2024-02-22 2025-08-28 Illumina, Inc. Techniques for dynamic range compression grouping in analyte assays
WO2025184234A1 (en) 2024-02-28 2025-09-04 Illumina, Inc. A personalized haplotype database for improved mapping and alignment of nucleotide reads and improved genotype calling
WO2025184226A1 (en) 2024-02-28 2025-09-04 Illumina, Inc. Nucleotides with terminal phosphate capping
WO2025188906A1 (en) 2024-03-08 2025-09-12 Illumina, Inc. Modified adenosine nucleotides
WO2025189105A1 (en) 2024-03-08 2025-09-12 Illumina, Inc. Size thresholding of dna fragments
WO2025193747A1 (en) 2024-03-12 2025-09-18 Illumina, Inc. Machine-learning models for ordering and expediting sequencing tasks or corresponding nucleotide-sample slides
US20250288988A1 (en) 2024-03-15 2025-09-18 10X Genomics, Inc. Systems and methods for covering and sealing an open well
WO2025198469A1 (en) 2024-03-18 2025-09-25 Agendia N.V. Prediction of response to immune therapy in triple negative breast cancer patients.
WO2025196650A1 (en) 2024-03-19 2025-09-25 Element Biosciences, Inc. Flow cell devices and use thereof
WO2025196731A1 (en) 2024-03-22 2025-09-25 Element Biosciences, Inc. Polymeric multivalent conjugates and related uses
WO2025196727A1 (en) 2024-03-22 2025-09-25 Element Biosciences, Inc. Macromolecular multivalent conjugates and related uses
WO2025207535A1 (en) 2024-03-26 2025-10-02 Illumina, Inc. Photo-switchable surfaces
WO2025207886A1 (en) 2024-03-28 2025-10-02 Illumina, Inc. Kits and methods for on-flow cell library preparation and methylation detection
WO2025217057A1 (en) 2024-04-08 2025-10-16 Illumina, Inc. Variant detection using improved sequence data alignments
WO2025230914A1 (en) 2024-04-29 2025-11-06 Illumina, Inc. Nucleotides with enzyme-triggered self-immolative linkers for sequencing by synthesis
WO2025235016A1 (en) 2024-05-07 2025-11-13 Element Biosciences, Inc. Sequencing method with spatial flexibility
WO2025240241A1 (en) 2024-05-13 2025-11-20 Illumina, Inc. Modifying sequencing cycles during a sequencing run to meet customized coverage estimations for a target genomic region
WO2025240924A1 (en) 2024-05-17 2025-11-20 Illumina, Inc. Blind equalization systems for base calling applications
WO2025240918A1 (en) 2024-05-17 2025-11-20 10X Genomics, Inc. Systems and methods for generating codebooks
WO2025250794A1 (en) 2024-05-31 2025-12-04 Illumina, Inc. Two-copy allele detection
WO2025250996A2 (en) 2024-05-31 2025-12-04 Illumina, Inc. Call generation and recalibration models for implementing personalized diploid reference haplotypes in genotype calling
WO2025255457A1 (en) 2024-06-07 2025-12-11 10X Genomics, Inc. Compositions and methods for improved on-target spatial profiling
WO2025264702A1 (en) 2024-06-18 2025-12-26 10X Genomics, Inc. 3d hydrogels for nucleic acid sequencing
WO2025264831A1 (en) 2024-06-18 2025-12-26 Illumina, Inc. Methods for increasing sequencing quality of gc-rich regions
WO2025264836A1 (en) 2024-06-18 2025-12-26 Illumina, Inc. Methods for increasing sequencing quality of gc-rich regions
WO2026006314A1 (en) 2024-06-28 2026-01-02 Illumina, Inc. Tagging target regions prior to nucleotide sequencing
WO2026006771A1 (en) 2024-06-28 2026-01-02 Illumina, Inc. Cluster-filtering scores
WO2026006746A2 (en) 2024-06-28 2026-01-02 Illumina, Inc. Nucleic acid preparation and analysis techniques
WO2026006774A1 (en) 2024-06-28 2026-01-02 Illumina, Inc. Altered cytidine deaminases and methods of use

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US5175269A (en) 1984-01-30 1992-12-29 Enzo Diagnostics, Inc. Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4824775A (en) * 1985-01-03 1989-04-25 Molecular Diagnostics, Inc. Cells labeled with multiple Fluorophores bound to a nucleic acid carrier
US4772691A (en) * 1985-06-05 1988-09-20 The Medical College Of Wisconsin, Inc. Chemically cleavable nucleotides
US4863849A (en) * 1985-07-18 1989-09-05 New York Medical College Automatable process for sequencing nucleotide
US5151507A (en) 1986-07-02 1992-09-29 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
SE8801070D0 (sv) 1988-03-23 1988-03-23 Pharmacia Ab Method for immobilizing a dna sequence on a solid support
US5174962A (en) * 1988-06-20 1992-12-29 Genomyx, Inc. Apparatus for determining DNA sequences by mass spectrometry
GB8910880D0 (en) 1989-05-11 1989-06-28 Amersham Int Plc Sequencing method
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
JPH07111484B2 (ja) * 1989-06-26 1995-11-29 松下電器産業株式会社 プラスチック製光学部品の反射防止膜とその形成方法
US5302509A (en) * 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
EP0450060A1 (en) 1989-10-26 1991-10-09 Sri International Dna sequencing
AU2674092A (en) 1991-09-09 1993-04-05 Baylor College Of Medicine Method and device for rapid dna or rna sequencing determination by a base addition sequencing scheme
DE4141178A1 (de) 1991-12-13 1993-06-17 Europ Lab Molekularbiolog Verfahren zur sequenzierung von nukleinsaeuren
GB9208733D0 (en) 1992-04-22 1992-06-10 Medical Res Council Dna sequencing method
GB9210176D0 (en) * 1992-05-12 1992-06-24 Cemu Bioteknik Ab Chemical method
US5436143A (en) * 1992-12-23 1995-07-25 Hyman; Edward D. Method for enzymatic synthesis of oligonucleotides
US5516664A (en) * 1992-12-23 1996-05-14 Hyman; Edward D. Enzymatic synthesis of repeat regions of oligonucleotides
US6074823A (en) * 1993-03-19 2000-06-13 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
FR2703052B1 (fr) 1993-03-26 1995-06-02 Pasteur Institut Nouvelle méthode de séquençage d'acides nucléiques.
GB9315847D0 (en) * 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
US5547859A (en) * 1993-08-02 1996-08-20 Goodman; Myron F. Chain-terminating nucleotides for DNA sequencing methods
EP0765401B1 (en) * 1993-11-17 2001-02-21 Amersham Pharmacia Biotech UK Limited Primer extension mass spectroscopy nucleic acid sequencing method
US5808045A (en) * 1994-09-02 1998-09-15 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US6232465B1 (en) * 1994-09-02 2001-05-15 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US5763594A (en) * 1994-09-02 1998-06-09 Andrew C. Hiatt 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US5872244A (en) 1994-09-02 1999-02-16 Andrew C. Hiatt 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US6214987B1 (en) * 1994-09-02 2001-04-10 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides
JPH10509429A (ja) * 1994-10-14 1998-09-14 ストラティジーン ポリヌクレオチドのポルフィリン標識
SE9500342D0 (sv) 1995-01-31 1995-01-31 Marek Kwiatkowski Novel chain terminators, the use thereof for nucleic acid sequencing and synthesis and a method of their preparation
AU5171696A (en) 1995-02-27 1996-09-18 Ely Michael Rabani Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism
EP0745686A1 (en) * 1995-06-01 1996-12-04 Roche Diagnostics GmbH The use of DNA polymerase 3'-intrinsic editing activity
US6613508B1 (en) * 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6312893B1 (en) * 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
EP0992511B1 (en) 1996-01-23 2009-03-11 Operon Biotechnologies, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
US6005125A (en) 1996-05-06 1999-12-21 Rutgers The State University Of New Jersey Universal allyl linker for solid-phase nucleic acid synthesis
US5821356A (en) * 1996-08-12 1998-10-13 The Perkin Elmer Corporation Propargylethoxyamino nucleotides
US5885775A (en) * 1996-10-04 1999-03-23 Perseptive Biosystems, Inc. Methods for determining sequences information in polynucleotides using mass spectrometry
EP1015629A1 (en) 1997-01-08 2000-07-05 Proligo L.L.C. Bioconjugation of oligonucleotides
US6046005A (en) 1997-01-15 2000-04-04 Incyte Pharmaceuticals, Inc. Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group
US6136543A (en) * 1997-01-31 2000-10-24 Hitachi, Ltd. Method for determining nucleic acids base sequence and apparatus therefor
PT1017848E (pt) 1997-07-28 2003-02-28 Medical Biosystems Ltd Analise de sequencias de acido nucleico
US6008379A (en) * 1997-10-01 1999-12-28 The Perkin-Elmer Corporation Aromatic-substituted xanthene dyes
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
GB9815163D0 (en) 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds
US6780591B2 (en) * 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
CA2330673C (en) 1998-05-01 2009-05-26 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and dna molecules
US6096875A (en) 1998-05-29 2000-08-01 The Perlein-Elmer Corporation Nucleotide compounds including a rigid linker
US6218530B1 (en) * 1998-06-02 2001-04-17 Ambergen Inc. Compounds and methods for detecting biomolecules
US6287821B1 (en) * 1998-06-11 2001-09-11 Orchid Biosciences, Inc. Nucleotide analogues with 3'-pro-fluorescent fluorophores in nucleic acid sequence analysis
US6218118B1 (en) * 1998-07-09 2001-04-17 Agilent Technologies, Inc. Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry
ATE309390T1 (de) 1998-07-30 2005-11-15 Solexa Ltd Matrizen von biomolekülen und ihre verwendung in sequenzierung
GB0002310D0 (en) 2000-02-01 2000-03-22 Solexa Ltd Polynucleotide sequencing
US6787308B2 (en) * 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
DE19844931C1 (de) * 1998-09-30 2000-06-15 Stefan Seeger Verfahren zur DNS- oder RNS-Sequenzierung
US6451525B1 (en) 1998-12-03 2002-09-17 Pe Corporation (Ny) Parallel sequencing method
US6380378B1 (en) 1998-12-24 2002-04-30 Toagosei Company, Ltd. Nucleotide compound, nucleotide block oligonucleotide, and method for producing them
ATE508200T1 (de) 1999-02-23 2011-05-15 Caliper Life Sciences Inc Sequenzierung durch inkorporation
DK1159453T3 (da) * 1999-03-10 2008-10-06 Asm Scient Inc Fremgangsmåde til direkte nukleinsyresekventering
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6242193B1 (en) * 1999-07-30 2001-06-05 Hitachi, Ltd. Apparatus for determining base sequence of nucleic acid
US6982146B1 (en) * 1999-08-30 2006-01-03 The United States Of America As Represented By The Department Of Health And Human Services High speed parallel molecular nucleic acid sequencing
WO2001016375A2 (en) 1999-08-30 2001-03-08 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services High speed parallel molecular nucleic acid sequencing
EP1218543A2 (en) 1999-09-29 2002-07-03 Solexa Ltd. Polynucleotide sequencing
US6309836B1 (en) 1999-10-05 2001-10-30 Marek Kwiatkowski Compounds for protecting hydroxyls and methods for their use
CA2388528A1 (en) 1999-11-04 2001-05-10 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US20030186256A1 (en) * 1999-12-23 2003-10-02 Achim Fischer Method for carrying out the parallel sequencing of a nucleic acid mixture on a surface
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
EP1182267B1 (en) 2000-03-30 2012-01-18 Toyota Jidosha Kabushiki Kaisha Method of determining base sequence of single nucleic acid molecule
GB0013276D0 (en) * 2000-06-01 2000-07-26 Amersham Pharm Biotech Uk Ltd Nucleotide analogues
GB0016473D0 (en) 2000-07-05 2000-08-23 Amersham Pharm Biotech Uk Ltd Sequencing method
WO2002022883A1 (en) 2000-09-11 2002-03-21 The Trustees Of Columbia University In The City Of New York Combinatorial fluorescence energy transfer tags and uses thereof
DE10045592A1 (de) 2000-09-15 2002-03-28 Klaus Pfizenmaier Ein Antikörper-TNF-TNF Inhibitor Fusionsprotein (TNF-Selektokin) als zielspezifisches Prozytokin zur Tumortherapie
EP3034627B1 (en) * 2000-10-06 2019-01-30 The Trustees of Columbia University in the City of New York Massive parallel method for decoding dna and rna
JP2004523243A (ja) 2001-03-12 2004-08-05 カリフォルニア インスティチュート オブ テクノロジー 非同期性塩基伸長によってポリヌクレオチド配列を分析するための方法および装置
US20030027140A1 (en) 2001-03-30 2003-02-06 Jingyue Ju High-fidelity DNA sequencing using solid phase capturable dideoxynucleotides and mass spectrometry
DE10120797B4 (de) 2001-04-27 2005-12-22 Genovoxx Gmbh Verfahren zur Analyse von Nukleinsäureketten
DE10120798B4 (de) 2001-04-27 2005-12-29 Genovoxx Gmbh Verfahren zur Bestimmung der Genexpression
US6613523B2 (en) 2001-06-29 2003-09-02 Agilent Technologies, Inc. Method of DNA sequencing using cleavable tags
CA2452474C (en) * 2001-07-13 2012-03-06 Ambergen, Inc. Nucleotide compositions comprising photocleavable markers and methods of preparation thereof
WO2003020968A2 (de) 2001-08-29 2003-03-13 Genovoxx Gmbh Verfahren zur analyse von nukleinsäurekettensequenzen und der genexpression
GB0128526D0 (en) 2001-11-29 2002-01-23 Amersham Pharm Biotech Uk Ltd Nucleotide analogues
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
ATE304610T1 (de) 2002-04-04 2005-09-15 Biotage Ab Auf primer verlängerung basierendes verfahren, das nukleotide verwendet, die über spaltbare linker markiert sind
WO2003087302A2 (en) 2002-04-12 2003-10-23 Stratagene Dual-labeled nucleotides
US7074597B2 (en) 2002-07-12 2006-07-11 The Trustees Of Columbia University In The City Of New York Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
GB2395954A (en) 2002-08-23 2004-06-09 Solexa Ltd Modified nucleotides
ES2326077T3 (es) 2002-08-23 2009-09-30 Illumina Cambridge Limited Nucleotidos marcados.
GB0321306D0 (en) 2003-09-11 2003-10-15 Solexa Ltd Modified polymerases for improved incorporation of nucleotide analogues
US7067031B2 (en) * 2003-12-03 2006-06-27 Dew Engineering And Development Limited Process for making a ceramic armor plate
EP2436778A3 (en) 2004-03-03 2012-07-11 The Trustees of Columbia University in the City of New York Photocleavable fluorescent nucleotides for DNA sequencing on chip constructed by site-specific coupling chemistry
EP3981886A1 (en) 2011-09-23 2022-04-13 Illumina, Inc. Compositions for nucleic acid sequencing

Also Published As

Publication number Publication date
KR20050044668A (ko) 2005-05-12
DK3266791T3 (da) 2021-03-01
US20100028885A1 (en) 2010-02-04
ES2858359T3 (es) 2021-09-30
EP3858845A1 (en) 2021-08-04
US20060160075A1 (en) 2006-07-20
DK1451351T3 (en) 2017-03-27
SI3266791T1 (sl) 2021-04-30
CN1617937A (zh) 2005-05-18
WO2003048387A3 (en) 2003-10-16
US7566537B2 (en) 2009-07-28
PT1451351T (pt) 2017-03-29
US20030104437A1 (en) 2003-06-05
CY1118765T1 (el) 2017-07-12
PT3266791T (pt) 2021-03-03
EP2338893A1 (en) 2011-06-29
WO2003048387A2 (en) 2003-06-12
US7427673B2 (en) 2008-09-23
EP3266791A1 (en) 2018-01-10
CY1123882T1 (el) 2022-05-27
IL162170A0 (en) 2005-11-20
EP3266791B1 (en) 2021-01-27
CA2469066A1 (en) 2003-06-12
EP2338893B9 (en) 2019-12-25
US20060188901A1 (en) 2006-08-24
JP2005511058A (ja) 2005-04-28
EP1451351B1 (en) 2017-02-01
BR0214683A (pt) 2004-11-23
ES2620131T3 (es) 2017-06-27
AU2002349155A1 (en) 2003-06-17
US7057026B2 (en) 2006-06-06
US7785796B2 (en) 2010-08-31
EP2338893B1 (en) 2017-06-28
EP1451351A2 (en) 2004-09-01
HK1248710A1 (en) 2018-10-19

Similar Documents

Publication Publication Date Title
IS7291A (is) Merkt kirni
DE50204184D1 (de) Espressobrüheinrichtung
ATE524462T1 (de) C5-modifizierte indazolylpyrrolotriazine
DE50208022D1 (de) Wischblatt
DE50212173D1 (de) sgängern
DE50204386D1 (de) Kreuztransducer
DE50206021D1 (de) Schlauchklemme
DE50209238D1 (de) Kugelgelenk
ATE335486T1 (de) Hydrazono-malonitrile
DE50204551D1 (de) Kugelgelenk
DE50211604D1 (de) Chlag
DE50209410D1 (de) Kugelgelenk
DE50208372D1 (de) Schrankaufhängevorrichtung
DE50211290D1 (de) Handzange
DE50204794D1 (de) Kugelgelenk
DE50203412D1 (de) Schwenkkolbenverdränger
DE50203984D1 (de) Kugelgelenk
DE50208029D1 (de) Kugelgelenk
ATE355059T1 (de) Isoxazolopyridinone
DE50201862D1 (de) Messwandler
DE50203093D1 (de) Losradlager
ATA18372001A (de) Gelenksbolzenbaueinheit
ATE319694T1 (de) Phenylalkyne
DE50209293D1 (de) Amidpolymermasse
DE50207815D1 (de) Kugelgelenk