IN2014KN02423A - - Google Patents

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Publication number
IN2014KN02423A
IN2014KN02423A IN2423KON2014A IN2014KN02423A IN 2014KN02423 A IN2014KN02423 A IN 2014KN02423A IN 2423KON2014 A IN2423KON2014 A IN 2423KON2014A IN 2014KN02423 A IN2014KN02423 A IN 2014KN02423A
Authority
IN
India
Prior art keywords
present
compounds
abc
cftr
transporters
Prior art date
Application number
Other languages
English (en)
Inventor
Sara S Hadida Ruah
Peter D J Grootenhuis
Frederick Van Goor
Jinglan Zhou
Brian Bear
Mark T Miller
Jason Mccartney
Mehdi Michel Jamel Numa
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of IN2014KN02423A publication Critical patent/IN2014KN02423A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
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  • Biochemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
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  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
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  • Psychology (AREA)
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IN2423KON2014 2006-04-07 2007-04-09 IN2014KN02423A (enrdf_load_stackoverflow)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79045906P 2006-04-07 2006-04-07
PCT/US2007/008975 WO2007117715A2 (en) 2006-04-07 2007-04-09 Modulators of atp-binding cassette transporters

Publications (1)

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IN2014KN02423A true IN2014KN02423A (enrdf_load_stackoverflow) 2015-05-01

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US (9) US7776905B2 (enrdf_load_stackoverflow)
EP (5) EP3327016B1 (enrdf_load_stackoverflow)
JP (3) JP5420395B2 (enrdf_load_stackoverflow)
CN (2) CN101460489A (enrdf_load_stackoverflow)
AU (1) AU2007235260B2 (enrdf_load_stackoverflow)
BR (1) BRPI0710965B8 (enrdf_load_stackoverflow)
CA (2) CA2869945C (enrdf_load_stackoverflow)
CY (3) CY1116979T1 (enrdf_load_stackoverflow)
DK (3) DK2007756T3 (enrdf_load_stackoverflow)
ES (4) ES2554353T3 (enrdf_load_stackoverflow)
HU (4) HUE027630T2 (enrdf_load_stackoverflow)
IL (1) IL194576A (enrdf_load_stackoverflow)
IN (1) IN2014KN02423A (enrdf_load_stackoverflow)
LT (1) LT3091011T (enrdf_load_stackoverflow)
MX (1) MX2008012945A (enrdf_load_stackoverflow)
NZ (3) NZ571803A (enrdf_load_stackoverflow)
PL (4) PL3091011T3 (enrdf_load_stackoverflow)
PT (3) PT2007756E (enrdf_load_stackoverflow)
RU (1) RU2451018C2 (enrdf_load_stackoverflow)
SI (4) SI3327016T1 (enrdf_load_stackoverflow)
WO (1) WO2007117715A2 (enrdf_load_stackoverflow)
ZA (1) ZA200809290B (enrdf_load_stackoverflow)

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EP2007756A2 (en) 2008-12-31
PT3091011T (pt) 2018-03-07
US20100331344A1 (en) 2010-12-30
PL2674428T3 (pl) 2017-01-31
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NZ611485A (en) 2014-09-26
ES2882684T3 (es) 2021-12-02
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DK2674428T3 (en) 2016-04-18
AU2007235260B2 (en) 2013-05-30
US20220411410A1 (en) 2022-12-29
JP2015120762A (ja) 2015-07-02
CN103254177A (zh) 2013-08-21
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US20150119441A1 (en) 2015-04-30
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RU2008144124A (ru) 2010-05-20
HUE036165T2 (hu) 2018-06-28
EP2674428B1 (en) 2016-04-06
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US7776905B2 (en) 2010-08-17
US20160332997A1 (en) 2016-11-17
US10975061B2 (en) 2021-04-13
EP3327016A1 (en) 2018-05-30
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SI2007756T1 (sl) 2015-11-30
PT2007756E (pt) 2015-11-02
US20240092766A1 (en) 2024-03-21
DK2007756T3 (en) 2015-10-05
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US20200115366A1 (en) 2020-04-16
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CY1116979T1 (el) 2017-04-05
HUE026145T2 (en) 2016-05-30
SI3327016T1 (sl) 2021-09-30
BRPI0710965A2 (pt) 2012-01-31
PL2007756T3 (pl) 2016-01-29
US20180162842A1 (en) 2018-06-14
PL3091011T3 (pl) 2018-06-29
EP3882245A1 (en) 2021-09-22
ES2554353T3 (es) 2015-12-18
EP3327016B1 (en) 2021-06-16
EP3091011B1 (en) 2017-12-27
AU2007235260A1 (en) 2007-10-18
RU2451018C2 (ru) 2012-05-20
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