WO2010054138A3 - Modulators of atp-binding cassette transporters - Google Patents

Modulators of atp-binding cassette transporters Download PDF

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Publication number
WO2010054138A3
WO2010054138A3 PCT/US2009/063475 US2009063475W WO2010054138A3 WO 2010054138 A3 WO2010054138 A3 WO 2010054138A3 US 2009063475 W US2009063475 W US 2009063475W WO 2010054138 A3 WO2010054138 A3 WO 2010054138A3
Authority
WO
WIPO (PCT)
Prior art keywords
atp
modulators
binding cassette
present
cassette transporters
Prior art date
Application number
PCT/US2009/063475
Other languages
French (fr)
Other versions
WO2010054138A2 (en
Inventor
Sara S. Hadida Ruah
Peter D.J. Grootenhuis
Mark T. Miller
Jason Mccartney
Fredrick Van Goor
Mehdi Michel Djamel Numa
Jinglan Zhou
Brian Bear
Original Assignee
Vertex Pharmaceuticals, Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
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Priority to UAA201106976A priority Critical patent/UA110192C2/en
Priority to NZ592693A priority patent/NZ592693A/en
Priority to MX2011004834A priority patent/MX2011004834A/en
Priority to EP09795592A priority patent/EP2362874A2/en
Priority to JP2011535676A priority patent/JP2012508246A/en
Priority to CA2742980A priority patent/CA2742980A1/en
Priority to CN2009801539702A priority patent/CN102272128A/en
Application filed by Vertex Pharmaceuticals, Incorporated filed Critical Vertex Pharmaceuticals, Incorporated
Priority to RU2011122646/04A priority patent/RU2011122646A/en
Priority to BRPI0921234A priority patent/BRPI0921234B8/en
Priority to AU2009313409A priority patent/AU2009313409A1/en
Publication of WO2010054138A2 publication Critical patent/WO2010054138A2/en
Publication of WO2010054138A3 publication Critical patent/WO2010054138A3/en
Priority to IL212727A priority patent/IL212727A/en
Priority to ZA2011/03856A priority patent/ZA201103856B/en
Priority to IL233996A priority patent/IL233996A/en

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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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  • Hospice & Palliative Care (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
PCT/US2009/063475 2008-11-06 2009-11-06 Modulators of atp-binding cassette transporters WO2010054138A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
UAA201106976A UA110192C2 (en) 2008-11-06 2009-06-11 Modulators of atp-binding cassette transporter
AU2009313409A AU2009313409A1 (en) 2008-11-06 2009-11-06 Modulators of ATP-Binding cassette transporters
RU2011122646/04A RU2011122646A (en) 2008-11-06 2009-11-06 ATP-BINDING CASSETTE CARRIER MODULATORS
EP09795592A EP2362874A2 (en) 2008-11-06 2009-11-06 Modulators of atp-binding cassette transporters
JP2011535676A JP2012508246A (en) 2008-11-06 2009-11-06 Modulator of ATP-binding cassette transporter
CA2742980A CA2742980A1 (en) 2008-11-06 2009-11-06 Modulators of atp-binding cassette transporters
CN2009801539702A CN102272128A (en) 2008-11-06 2009-11-06 Modulators of atp-binding cassette transporters
NZ592693A NZ592693A (en) 2008-11-06 2009-11-06 Modulators of ATP-binding cassette (ABC) transporters including cystic fibrosis transmembrane conductance regulator (CFTR)
MX2011004834A MX2011004834A (en) 2008-11-06 2009-11-06 Modulators of atp-binding cassette transporters.
BRPI0921234A BRPI0921234B8 (en) 2008-11-06 2009-11-06 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS INCLUDING SUCH COMPOUNDS, IN VITRO USE AND USE OF SUCH COMPOUNDS AND KIT FOR USE IN MEASURING THE ACTIVITY OF AN ABC TRANSPORTER OR A FRAGMENT THEREOF IN AN IN VITRO OR IN VIVO BIOLOGICAL SAMPLE INCLUDING SUCH COMPOUNDS
IL212727A IL212727A (en) 2008-11-06 2011-05-05 Modulators of atp-binding cassette transporters, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for the treatment of diseases
ZA2011/03856A ZA201103856B (en) 2008-11-06 2011-05-25 Modulators of atp-binding cassette transporters
IL233996A IL233996A (en) 2008-11-06 2014-08-07 Use of modulators of atp-binding cassette transporters for the manufacture of medicaments for treating male infertility or pancreatic insufficiency

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11215208P 2008-11-06 2008-11-06
US61/112,152 2008-11-06

Publications (2)

Publication Number Publication Date
WO2010054138A2 WO2010054138A2 (en) 2010-05-14
WO2010054138A3 true WO2010054138A3 (en) 2010-11-11

Family

ID=42153560

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/063475 WO2010054138A2 (en) 2008-11-06 2009-11-06 Modulators of atp-binding cassette transporters

Country Status (17)

Country Link
EP (1) EP2362874A2 (en)
JP (2) JP2012508246A (en)
KR (1) KR20110089170A (en)
CN (2) CN105693701B (en)
AU (1) AU2009313409A1 (en)
BR (1) BRPI0921234B8 (en)
CA (2) CA2948104C (en)
CL (1) CL2011001004A1 (en)
HK (1) HK1226076A1 (en)
IL (2) IL212727A (en)
MX (1) MX2011004834A (en)
NZ (2) NZ592693A (en)
RU (2) RU2011122646A (en)
SG (1) SG10201501168RA (en)
UA (2) UA104876C2 (en)
WO (1) WO2010054138A2 (en)
ZA (1) ZA201103856B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8952050B2 (en) 2006-04-07 2015-02-10 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
LT2489659T (en) 2004-06-24 2018-03-26 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
HUE032640T2 (en) 2005-11-08 2017-10-30 Vertex Pharma Heterocyclic modulators of ATP-binding cassette transporters
RS60205B1 (en) 2005-12-28 2020-06-30 Vertex Pharma Pharmaceutical compositions of the amorphous form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
HUE055205T2 (en) 2006-04-07 2021-11-29 Vertex Pharma Preparation of modulators of atp-binding cassette transporters
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8969386B2 (en) 2007-05-09 2015-03-03 Vertex Pharmaceuticals Incorporated Modulators of CFTR
CN101910134B (en) 2007-12-07 2014-03-19 沃泰克斯药物股份有限公司 Processes for producing cycloalkylcarboxiamido-pyridine benzoic acids
US8507534B2 (en) 2007-12-07 2013-08-13 Vertex Pharmaceuticals Incorporated Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
CN103382201B (en) 2008-02-28 2016-12-28 沃泰克斯药物股份有限公司 Heteroaryl derivative as CFTR regulator
EP2940016A1 (en) * 2008-11-06 2015-11-04 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
UA104876C2 (en) * 2008-11-06 2014-03-25 Вертекс Фармасьютікалз Інкорпорейтед Modulators of atp-binding cassette transporters
LT2821400T (en) 2009-03-20 2018-02-12 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
RU2711481C2 (en) * 2010-03-25 2020-01-17 Вертекс Фармасьютикалз Инкорпорейтед Solid forms of (r)-1-(2, 2-difluorobenzo[d][1, 3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
JP2013523833A (en) 2010-04-07 2013-06-17 バーテックス ファーマシューティカルズ インコーポレイテッド 3- (6- (1- (2,2-difluorobenzo [D] [1,3] dioxol-5-yl) cyclopropanecarboxamido) -3-methylpyridin-2-yl) benzoic acid pharmaceutical composition and Its administration
CA2796646A1 (en) * 2010-04-22 2011-10-27 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions and administrations thereof
EP2560650A1 (en) * 2010-04-22 2013-02-27 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions and administrations thereof
CA2797118C (en) 2010-04-22 2021-03-30 Vertex Pharmaceuticals Incorporated Process of producing cycloalkylcarboxamido-indole compounds
CA2796642A1 (en) * 2010-04-22 2011-10-27 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions and administrations thereof
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US20120046330A1 (en) 2010-08-23 2012-02-23 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (r)-1-(2,2-difluorobenzo[d] [1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
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