NZ592693A - Modulators of ATP-binding cassette (ABC) transporters including cystic fibrosis transmembrane conductance regulator (CFTR) - Google Patents

Modulators of ATP-binding cassette (ABC) transporters including cystic fibrosis transmembrane conductance regulator (CFTR)

Info

Publication number
NZ592693A
NZ592693A NZ592693A NZ59269309A NZ592693A NZ 592693 A NZ592693 A NZ 592693A NZ 592693 A NZ592693 A NZ 592693A NZ 59269309 A NZ59269309 A NZ 59269309A NZ 592693 A NZ592693 A NZ 592693A
Authority
NZ
New Zealand
Prior art keywords
cystic fibrosis
abc
cftr
atp
modulators
Prior art date
Application number
NZ592693A
Inventor
Sara S Ruah
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42153560&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ592693(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Priority to NZ610972A priority Critical patent/NZ610972A/en
Publication of NZ592693A publication Critical patent/NZ592693A/en

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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D487/04—Ortho-condensed systems
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Abstract

ABSTRACT - 592693 Disclosed herein is a compound of formula (II) and a pharmaceutically acceptable salt thereof, wherein the variables are defined in the specification. These compounds are modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), and are useful for treating ABC transporter mediated condition, disease, or disorder selected from cystic fibrosis, hereditary emphysema, hereditary hemochromatosis, coagulation-fibrinolysis deficiency selected from protein C deficiency and Type 1 hereditary angioedema, lipid processing deficiencies (selected from familial hypercholesterolemia, Type 1 chylomicronemia and abetalipoproteinemia), lysosomal storage diseases, neurodegenerative diseases, polyglutamine neurological disorders, spongiform encephalopathies, COPD, dry-eye disease, and Sjögren's disease.
NZ592693A 2008-11-06 2009-11-06 Modulators of ATP-binding cassette (ABC) transporters including cystic fibrosis transmembrane conductance regulator (CFTR) NZ592693A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ610972A NZ610972A (en) 2008-11-06 2009-11-06 Modulators of atp-binding cassette transporters

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11215208P 2008-11-06 2008-11-06
PCT/US2009/063475 WO2010054138A2 (en) 2008-11-06 2009-11-06 Modulators of atp-binding cassette transporters

Publications (1)

Publication Number Publication Date
NZ592693A true NZ592693A (en) 2013-05-31

Family

ID=42153560

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ592693A NZ592693A (en) 2008-11-06 2009-11-06 Modulators of ATP-binding cassette (ABC) transporters including cystic fibrosis transmembrane conductance regulator (CFTR)
NZ610972A NZ610972A (en) 2008-11-06 2009-11-06 Modulators of atp-binding cassette transporters

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ610972A NZ610972A (en) 2008-11-06 2009-11-06 Modulators of atp-binding cassette transporters

Country Status (17)

Country Link
EP (1) EP2362874A2 (en)
JP (2) JP2012508246A (en)
KR (1) KR20110089170A (en)
CN (2) CN105693701B (en)
AU (1) AU2009313409A1 (en)
BR (1) BRPI0921234B8 (en)
CA (2) CA2742980A1 (en)
CL (1) CL2011001004A1 (en)
HK (1) HK1226076A1 (en)
IL (2) IL212727A (en)
MX (1) MX2011004834A (en)
NZ (2) NZ592693A (en)
RU (2) RU2011122646A (en)
SG (1) SG10201501168RA (en)
UA (2) UA104876C2 (en)
WO (1) WO2010054138A2 (en)
ZA (1) ZA201103856B (en)

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