PL2402002T3 - Kompozycje zawierające kwas 1,2,4-oksadiazolobenzoesowy i ich zastosowania do leczenia chorób związanych z przedwczesnym kodonem stop - Google Patents
Kompozycje zawierające kwas 1,2,4-oksadiazolobenzoesowy i ich zastosowania do leczenia chorób związanych z przedwczesnym kodonem stopInfo
- Publication number
- PL2402002T3 PL2402002T3 PL11175569T PL11175569T PL2402002T3 PL 2402002 T3 PL2402002 T3 PL 2402002T3 PL 11175569 T PL11175569 T PL 11175569T PL 11175569 T PL11175569 T PL 11175569T PL 2402002 T3 PL2402002 T3 PL 2402002T3
- Authority
- PL
- Poland
- Prior art keywords
- oxadiazole
- compositions
- stop codon
- diseases associated
- treating diseases
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Neurology (AREA)
- Hematology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
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- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
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- Physiology (AREA)
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- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66978905P | 2005-04-08 | 2005-04-08 | |
US78739506P | 2006-03-30 | 2006-03-30 | |
EP06749439A EP1874306B1 (en) | 2005-04-08 | 2006-04-06 | Compositions of an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy |
EP11175569.0A EP2402002B1 (en) | 2005-04-08 | 2006-04-06 | Compositions comprising an 1,2,4-oxadiazole and uses thereof for treating diseases associated with a premature stop codon |
PCT/US2006/012887 WO2006110483A1 (en) | 2005-04-08 | 2006-04-06 | Compositions of an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2402002T3 true PL2402002T3 (pl) | 2018-11-30 |
Family
ID=36763092
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL06749439T PL1874306T3 (pl) | 2005-04-08 | 2006-04-06 | Kompozycje zawierające 1,2,4-oksadiazol aktywny po podaniu doustnie w celu supresyjnego leczenia niesensownej mutacji |
PL11175569T PL2402002T3 (pl) | 2005-04-08 | 2006-04-06 | Kompozycje zawierające kwas 1,2,4-oksadiazolobenzoesowy i ich zastosowania do leczenia chorób związanych z przedwczesnym kodonem stop |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL06749439T PL1874306T3 (pl) | 2005-04-08 | 2006-04-06 | Kompozycje zawierające 1,2,4-oksadiazol aktywny po podaniu doustnie w celu supresyjnego leczenia niesensownej mutacji |
Country Status (17)
Country | Link |
---|---|
US (7) | US8716321B2 (pl) |
EP (2) | EP1874306B1 (pl) |
JP (3) | JP5800451B2 (pl) |
CN (1) | CN103720688A (pl) |
AU (1) | AU2006235115C1 (pl) |
BR (1) | BRPI0609089A2 (pl) |
CA (1) | CA2603402C (pl) |
DK (2) | DK2402002T3 (pl) |
ES (2) | ES2390804T3 (pl) |
HK (1) | HK1111897A1 (pl) |
IL (2) | IL186433A (pl) |
MX (1) | MX2007012206A (pl) |
NO (2) | NO339909B1 (pl) |
NZ (1) | NZ562197A (pl) |
PL (2) | PL1874306T3 (pl) |
PT (2) | PT2402002T (pl) |
WO (1) | WO2006110483A1 (pl) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1618098E (pt) | 2003-04-11 | 2015-02-10 | Ptc Therapeutics Inc | Compostos de ácido 1,2,4-oxadiazolebenzóico e sua utilização para supressão sem sentido e o tratamento de doenças |
ES2390804T3 (es) | 2005-04-08 | 2012-11-16 | Ptc Therapeutics, Inc. | Composiciones de un 1,2,4-oxadiazol oralmente activo para terapia de supresión de la mutación sin sentido |
EP2387995A1 (en) | 2006-03-30 | 2011-11-23 | PTC Therapeutics, Inc. | Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith |
EP3327016B1 (en) | 2006-04-07 | 2021-06-16 | Vertex Pharmaceuticals Incorporated | Preparation of modulators of atp-binding cassette transporters |
US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
BRPI0716996B8 (pt) | 2006-09-08 | 2021-05-25 | Ptc Therapeutics Inc | processo para preparar um composto |
ES2563958T3 (es) * | 2006-09-25 | 2016-03-16 | Ptc Therapeutics, Inc. | Formas cristalinas del ácido 3-[5-(2-fluorofenil)-[1,2,4]-oxadiazol-3-il]-benzoico |
WO2008130370A1 (en) | 2006-09-25 | 2008-10-30 | Ptc Therapeutics, Inc. | Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, compositions thereof and the use for nonsense suppression |
AU2016262645B2 (en) * | 2006-10-12 | 2018-05-17 | Ptc Therapeutics, Inc. | Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy |
KR20090074231A (ko) | 2006-10-12 | 2009-07-06 | 피티씨 테라퓨틱스, 인크. | 넌센스 돌연변이 억제 치료를 위한 경구 활성 1,2,4-옥사디아졸의 투여 방법 |
US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
CA2685540C (en) | 2007-08-03 | 2018-10-16 | Graham Michael Wynne | Drug combinations for the treatment of duchenne muscular dystrophy |
GB0715087D0 (en) | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
WO2009064959A1 (en) | 2007-11-16 | 2009-05-22 | Vertex Pharmaceuticals Incorporated | Isoquinoline modulators of atp-binding cassette transporters |
EP2225230B1 (en) | 2007-12-07 | 2016-11-16 | Vertex Pharmaceuticals Incorporated | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid |
NZ600772A (en) | 2008-03-31 | 2013-10-25 | Vertex Pharma | Pyridyl derivatives as CFTR modulators |
MX347804B (es) | 2010-03-25 | 2017-05-15 | Vertex Pharmaceuticals Incorporated * | Formas solidas de (r)-1(2,2-difluorobenzo[d] [1,3]dioxol-5-il)-n-( 1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il) -1h-indol-5-il) ciclopropanocarboxamida. |
US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
DK2555754T3 (en) | 2010-04-07 | 2016-04-18 | Vertex Pharma | Solid forms of 3- (6- (1- (2,2-difluoro-benzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido) -3-methylpyridin-2-yl) -benzoic acid |
HUE056525T2 (hu) | 2010-04-07 | 2022-02-28 | Vertex Pharma | 3-(6-(1-(2,2-Difluorbenzo[d][1,3]dioxol-5-il)ciklopropánkarboxamido)-3-metilpiridin-2-il)benzoesav gyógyszerészeti készítményei és azok adagolása |
EP2560954B1 (en) | 2010-04-22 | 2016-10-05 | Vertex Pharmaceuticals Incorporated | Process of producing cycloalkylcarboxamido-indole compounds |
US8563593B2 (en) | 2010-06-08 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
CA2806825C (en) * | 2010-08-05 | 2018-08-21 | Institut Pasteur De Lille | Compound useful for the treatment of nonsense-mutation-mediated diseases and pharmaceutical composition comprising said compound |
WO2012027247A2 (en) | 2010-08-23 | 2012-03-01 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration therof |
CA2852991C (en) | 2011-11-08 | 2019-12-31 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
CA2862859C (en) | 2012-01-25 | 2022-08-02 | Vertex Pharmaceuticals Incorporated | Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
WO2014014841A1 (en) | 2012-07-16 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof |
LT2914248T (lt) | 2012-11-02 | 2018-11-26 | Vertex Pharmaceuticals Incorporated | Farmacinės kompozicijos, skirtos cftr medijuotų ligų gydymui |
WO2014153643A1 (en) * | 2013-03-26 | 2014-10-02 | The University Of British Columbia | Compositions and methods for use thereof in the treatment of aniridia |
CN106455571A (zh) * | 2014-03-06 | 2017-02-22 | Ptc医疗公司 | 1,2,4‑噁二唑苯甲酸的药物组合物和盐 |
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