NO20075682L - Sammensetninger omfattende et oralt aktivt 1,2,4-oksadiazol for nonsense mutasjonsundertrykkelsesterapi - Google Patents

Sammensetninger omfattende et oralt aktivt 1,2,4-oksadiazol for nonsense mutasjonsundertrykkelsesterapi

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Publication number
NO20075682L
NO20075682L NO20075682A NO20075682A NO20075682L NO 20075682 L NO20075682 L NO 20075682L NO 20075682 A NO20075682 A NO 20075682A NO 20075682 A NO20075682 A NO 20075682A NO 20075682 L NO20075682 L NO 20075682L
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NO
Norway
Prior art keywords
oxadiazole
nonsense
mutational
compositions
orally active
Prior art date
Application number
NO20075682A
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English (en)
Other versions
NO339909B1 (no
Inventor
Samit Hirawat
Langdon Miller
Original Assignee
Ptc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc
Publication of NO20075682L publication Critical patent/NO20075682L/no
Priority to NO20170035A priority Critical patent/NO340617B1/no
Publication of NO339909B1 publication Critical patent/NO339909B1/no

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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Abstract

Den foreliggende oppfinnelsen er relatert til spesifikke doser og doseringskurer for å benytte 1,2,4-oxadiazol benzosyreforbindelse i behandling eller forebygging av sykdommer assosiert med nonsens mutasjoner. Nærmere bestemt er oppfinnelsen relatert til spesifikke doser og doseringskurer for anvendelsen av 3-[5-(2-fluorfenyl)[1,2,4]oxadiazol-3-yl]-benzosyre i pattedyr som har sykdommer assosiert med nonsens mutasjoner.
NO20075682A 2005-04-08 2007-11-07 Sammensetninger av et oralt aktivt 1,2,4-oxadiazol for ”nonsens” mutasjon undertrykkende terapi NO339909B1 (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO20170035A NO340617B1 (no) 2005-04-08 2017-01-09 Farmasøytisk sammensetning omfattende i form av granuler i en enhetsdoseringsformulering en 1,2,4-oxadiazol benzosyreforbindelse for behandling av en sykdom assosiert med et prematurt stoppcodon

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66978905P 2005-04-08 2005-04-08
US78739506P 2006-03-30 2006-03-30
PCT/US2006/012887 WO2006110483A1 (en) 2005-04-08 2006-04-06 Compositions of an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy

Publications (2)

Publication Number Publication Date
NO20075682L true NO20075682L (no) 2008-01-07
NO339909B1 NO339909B1 (no) 2017-02-13

Family

ID=36763092

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20075682A NO339909B1 (no) 2005-04-08 2007-11-07 Sammensetninger av et oralt aktivt 1,2,4-oxadiazol for ”nonsens” mutasjon undertrykkende terapi
NO20170035A NO340617B1 (no) 2005-04-08 2017-01-09 Farmasøytisk sammensetning omfattende i form av granuler i en enhetsdoseringsformulering en 1,2,4-oxadiazol benzosyreforbindelse for behandling av en sykdom assosiert med et prematurt stoppcodon

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20170035A NO340617B1 (no) 2005-04-08 2017-01-09 Farmasøytisk sammensetning omfattende i form av granuler i en enhetsdoseringsformulering en 1,2,4-oxadiazol benzosyreforbindelse for behandling av en sykdom assosiert med et prematurt stoppcodon

Country Status (17)

Country Link
US (7) US8716321B2 (no)
EP (2) EP2402002B1 (no)
JP (3) JP5800451B2 (no)
CN (1) CN103720688A (no)
AU (1) AU2006235115C1 (no)
BR (1) BRPI0609089A2 (no)
CA (1) CA2603402C (no)
DK (2) DK2402002T3 (no)
ES (2) ES2390804T3 (no)
HK (1) HK1111897A1 (no)
IL (2) IL186433A (no)
MX (1) MX2007012206A (no)
NO (2) NO339909B1 (no)
NZ (1) NZ562197A (no)
PL (2) PL1874306T3 (no)
PT (2) PT2402002T (no)
WO (1) WO2006110483A1 (no)

Families Citing this family (49)

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CL2007002743A1 (es) * 2006-09-25 2008-07-11 Pct Therapeutics Inc Soc Organ Forma cristalina del acido 3-[5-(2-fluorofenil)-[1,2,4]oxadiazol-3-il]-benzoico; composicion farmaceutica que comprende a dicha forma cristalina; y su uso para modular la terminacion prematura de traslado o decaimiento de marn, tales como carcicoma.
AU2016262645B2 (en) * 2006-10-12 2018-05-17 Ptc Therapeutics, Inc. Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy
SI2073805T1 (sl) 2006-10-12 2015-10-30 Ptc Therapeutics, Inc. Postopki za odmerjanje peroralno aktivnega 1,2,4-oksadiazola za zdravljenje supresije nesmiselnih mutacij
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
JP2010535708A (ja) 2007-08-03 2010-11-25 ビオマリン アイジーエー リミテッド デュシェンヌ型筋ジストロフィーの治療のための薬物併用
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PL2217572T3 (pl) 2007-11-16 2014-04-30 Vertex Pharma Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP
SG186638A1 (en) 2007-12-07 2013-01-30 Vertex Pharma Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
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US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
ES2845449T3 (es) 2010-03-25 2021-07-26 Vertex Pharma Dispersión sólida de forma amorfa de (R)-1(2,2-difluorobenzo[d][1,3]dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluoro-2(1-hidroxi-2-metilpropan-2-il)-1h-indol-5il)-ciclopropanocarboxamida
RU2592368C2 (ru) 2010-04-07 2016-07-20 Вертекс Фармасьютикалз Инкорпорейтед ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ВКЛЮЧАЮЩИЕ 3-(2, 2-ДИФТОРБЕНЗО[d][1, 3]ДИОКСОЛ-5-ИЛ)ЦИКЛОПРОПАНКАРБОКСАМИДО)-3-МЕТИЛПИРИДИН-2-ИЛ)БЕНЗОЙНУЮ КИСЛОТУ, И ИХ ВВЕДЕНИЕ
TWI549950B (zh) 2010-04-07 2016-09-21 維泰克斯製藥公司 ３－（６－（１－（２，２－二氟苯并［ｄ］［１，３］二氧雜環戊烯－５－基）環丙烷甲醯胺基）－３－甲基吡啶－２－基）苯甲酸之固體形式
EP3381899B1 (en) 2010-04-22 2021-01-06 Vertex Pharmaceuticals Incorporated Intermediate compound for process of producing cycloalkylcarboxamido-indole compounds
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