SI2073805T1 - Postopki za odmerjanje peroralno aktivnega 1,2,4-oksadiazola za zdravljenje supresije nesmiselnih mutacij - Google Patents

Postopki za odmerjanje peroralno aktivnega 1,2,4-oksadiazola za zdravljenje supresije nesmiselnih mutacij

Info

Publication number
SI2073805T1
SI2073805T1 SI200731657T SI200731657T SI2073805T1 SI 2073805 T1 SI2073805 T1 SI 2073805T1 SI 200731657 T SI200731657 T SI 200731657T SI 200731657 T SI200731657 T SI 200731657T SI 2073805 T1 SI2073805 T1 SI 2073805T1
Authority
SI
Slovenia
Prior art keywords
oxadiazole
dosing
methods
nonsense mutation
orally active
Prior art date
Application number
SI200731657T
Other languages
English (en)
Inventor
Samit Hirawat
Langdon Miller
Original Assignee
Ptc Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39102963&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2073805(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ptc Therapeutics, Inc. filed Critical Ptc Therapeutics, Inc.
Publication of SI2073805T1 publication Critical patent/SI2073805T1/sl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
SI200731657T 2006-10-12 2007-10-11 Postopki za odmerjanje peroralno aktivnega 1,2,4-oksadiazola za zdravljenje supresije nesmiselnih mutacij SI2073805T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85145006P 2006-10-12 2006-10-12
EP07852738.9A EP2073805B1 (en) 2006-10-12 2007-10-11 Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy
PCT/US2007/021921 WO2008045566A1 (en) 2006-10-12 2007-10-11 Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy

Publications (1)

Publication Number Publication Date
SI2073805T1 true SI2073805T1 (sl) 2015-10-30

Family

ID=39102963

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200731657T SI2073805T1 (sl) 2006-10-12 2007-10-11 Postopki za odmerjanje peroralno aktivnega 1,2,4-oksadiazola za zdravljenje supresije nesmiselnih mutacij

Country Status (24)

Country Link
US (7) US9226919B2 (sl)
EP (2) EP2073805B1 (sl)
JP (4) JP2010506840A (sl)
KR (4) KR20090074231A (sl)
CN (2) CN101553226B (sl)
AU (1) AU2007308067B2 (sl)
BR (2) BRPI0719276A2 (sl)
CA (1) CA2675518C (sl)
CL (1) CL2007002923A1 (sl)
DK (1) DK2073805T3 (sl)
ES (1) ES2538359T3 (sl)
HK (2) HK1136214A1 (sl)
HR (1) HRP20150590T1 (sl)
IL (2) IL198147A (sl)
MX (1) MX2009003909A (sl)
NO (1) NO342061B1 (sl)
PE (4) PE20080982A1 (sl)
PL (1) PL2073805T3 (sl)
PT (1) PT2073805E (sl)
RS (1) RS54025B1 (sl)
RU (1) RU2462247C2 (sl)
SI (1) SI2073805T1 (sl)
TW (1) TWI405570B (sl)
WO (1) WO2008045566A1 (sl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3345895T1 (sl) 2003-04-11 2020-03-31 Ptc Therapeutics, Inc. Spojina 1,2,4-oksadiazol benzojske kisline in njena uporaba za supresijo nesmiselne in zdravljenje bolezni
EP2387995A1 (en) 2006-03-30 2011-11-23 PTC Therapeutics, Inc. Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith
RS54025B1 (en) 2006-10-12 2015-10-30 Ptc Therapeutics Inc. DOSAGE PROCEDURES FOR ORALLY ACTIVE 1,2,4-OXADIAZOLE FOR NONSENS MUTATION SUPPRESSION THERAPY
EP2714937B1 (en) 2011-06-03 2018-11-14 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
CA2942147C (en) 2014-03-06 2022-12-13 Ptc Therapeutics, Inc. Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid
ES2926687T3 (es) 2014-08-28 2022-10-27 Eisai R&D Man Co Ltd Derivado de quinolina muy puro y método para su producción
US20180028662A1 (en) 2015-02-25 2018-02-01 Eisai R&D Management Co., Ltd. Method for Suppressing Bitterness of Quinoline Derivative
CA2988707C (en) 2015-06-16 2023-10-10 Eisai R&D Management Co., Ltd. Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
AR106530A1 (es) 2015-10-30 2018-01-24 Ptc Therapeutics Inc Métodos para tratar epilepsia
JP7235741B2 (ja) 2017-10-19 2023-03-08 シプラ ユーエスエイ， インコーポレイテッド 抗菌性アミノグリコシド類似体の合成
EP3713934B1 (en) 2017-11-23 2022-04-13 Universita' degli Studi di Palermo Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations
US20240139183A1 (en) * 2021-02-16 2024-05-02 Ribotech Co., Ltd. Compound for suppressing nonsense-mediated mrna decay
KR102378381B1 (ko) * 2021-08-23 2022-03-24 라이보텍(주) 넌센스-매개 mRNA 분해를 억제하기 위한 화합물
EP4337267A1 (en) * 2021-05-11 2024-03-20 RegenxBio Inc. Treatment of duchenne muscular dystrophy and combinations thereof
KR102665711B1 (ko) * 2021-12-21 2024-05-14 재단법인 아산사회복지재단 Ras 활성도를 이용한 신경섬유종증 치료제에 대한 감수성 예측용 바이오마커 조성물 및 Ras 활성 억제제를 포함하는 신경섬유종증 예방 또는 치료용 약학적 조성물

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US6660753B2 (en) * 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
CA2449544A1 (en) * 2001-06-08 2002-12-19 Cytovia, Inc. Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs
MY151199A (en) * 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
MXPA05001592A (es) * 2002-08-09 2005-05-05 Astrazeneca Ab Oxadiazoles como moduladores de receptor-5 de glutamato metabotropico.
GB0303503D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
SI3345895T1 (sl) * 2003-04-11 2020-03-31 Ptc Therapeutics, Inc. Spojina 1,2,4-oksadiazol benzojske kisline in njena uporaba za supresijo nesmiselne in zdravljenje bolezni
WO2004110351A2 (en) * 2003-05-14 2004-12-23 Anadys Pharmaceuticals, Inc. Heterocyclic compounds for treating hepatitis c virus
AU2004308973A1 (en) * 2003-12-23 2005-07-14 Alza Corporation Methods and dosage forms for increasing solubility of drug compositions for controlled delivery
ES2390804T3 (es) * 2005-04-08 2012-11-16 Ptc Therapeutics, Inc. Composiciones de un 1,2,4-oxadiazol oralmente activo para terapia de supresión de la mutación sin sentido
US20070010553A1 (en) * 2005-07-01 2007-01-11 Astrazeneca Ab New use
ZA200901782B (en) 2006-09-08 2010-06-30 Ptc Therapeutics Inc Processes for the preparation of 1, 2, 4-oxadiazole benzoic acids
EP2559689B1 (en) 2006-09-25 2017-11-29 PTC Therapeutics, Inc. Preparation process for crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]benzoic acid
RS54025B1 (en) 2006-10-12 2015-10-30 Ptc Therapeutics Inc. DOSAGE PROCEDURES FOR ORALLY ACTIVE 1,2,4-OXADIAZOLE FOR NONSENS MUTATION SUPPRESSION THERAPY

Also Published As

Publication number Publication date
US20180140583A1 (en) 2018-05-24
EP2460520A1 (en) 2012-06-06
WO2008045566B1 (en) 2008-06-19
EP2460520B1 (en) 2015-09-30
IL198147A0 (en) 2009-12-24
PE20120670A1 (es) 2012-06-01
HRP20150590T1 (hr) 2015-07-03
NO20091826L (no) 2009-07-08
PE20080982A1 (es) 2008-07-19
HK1170690A1 (zh) 2013-03-08
US20210038572A1 (en) 2021-02-11
IL236519A (en) 2017-03-30
ES2538359T3 (es) 2015-06-19
US20170049752A1 (en) 2017-02-23
PT2073805E (pt) 2015-07-13
JP2017081946A (ja) 2017-05-18
EP2073805A1 (en) 2009-07-01
RU2009117590A (ru) 2010-11-20
CL2007002923A1 (es) 2008-06-06
US10849885B2 (en) 2020-12-01
KR101758341B1 (ko) 2017-07-14
KR20170100072A (ko) 2017-09-01
HK1136214A1 (en) 2010-06-25
KR20160128468A (ko) 2016-11-07
AU2007308067A1 (en) 2008-04-17
US9737513B2 (en) 2017-08-22
US20190099405A1 (en) 2019-04-04
RS54025B1 (en) 2015-10-30
CN101553226A (zh) 2009-10-07
JP2010506840A (ja) 2010-03-04
US9226919B2 (en) 2016-01-05
JP6129713B2 (ja) 2017-05-17
MX2009003909A (es) 2009-05-25
CA2675518C (en) 2017-11-14
WO2008045566A1 (en) 2008-04-17
CN103211766B (zh) 2015-03-11
CN101553226B (zh) 2015-05-13
CN103211766A (zh) 2013-07-24
JP6333227B2 (ja) 2018-05-30
BR122019020961B1 (pt) 2021-03-09
BRPI0719276A2 (pt) 2014-04-29
AU2007308067B2 (en) 2013-05-30
RU2462247C2 (ru) 2012-09-27
IL198147A (en) 2016-02-29
US9522137B2 (en) 2016-12-20
IL236519A0 (en) 2015-02-26
CA2675518A1 (en) 2008-04-17
KR20090074231A (ko) 2009-07-06
NO342061B1 (no) 2018-03-19
US9877952B2 (en) 2018-01-30
EP2073805B1 (en) 2015-03-04
US20080114039A1 (en) 2008-05-15
JP2016029078A (ja) 2016-03-03
PL2073805T3 (pl) 2015-08-31
TWI405570B (zh) 2013-08-21
KR20150064244A (ko) 2015-06-10
US10172836B2 (en) 2019-01-08
PE20160947A1 (es) 2016-09-26
BR122019020961B8 (pt) 2021-07-27
TW200820968A (en) 2008-05-16
JP2014058533A (ja) 2014-04-03
DK2073805T3 (da) 2015-06-15
US20160101087A1 (en) 2016-04-14
PE20212245A1 (es) 2021-11-24
US20170304275A1 (en) 2017-10-26

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