DK2073805T3 - Fremgangsmåder til dosering af en oralt aktiv 1,2,4-oxadiazol til terapi for suppression af nonsens-mutation - Google Patents

Fremgangsmåder til dosering af en oralt aktiv 1,2,4-oxadiazol til terapi for suppression af nonsens-mutation Download PDF

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Publication number
DK2073805T3
DK2073805T3 DK07852738.9T DK07852738T DK2073805T3 DK 2073805 T3 DK2073805 T3 DK 2073805T3 DK 07852738 T DK07852738 T DK 07852738T DK 2073805 T3 DK2073805 T3 DK 2073805T3
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oxadiazole
dosing
suppression
therapy
methods
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DK07852738.9T
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English (en)
Inventor
Samit Hirawat
Langdon Miller
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Ptc Therapeutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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DK07852738.9T 2006-10-12 2007-10-11 Fremgangsmåder til dosering af en oralt aktiv 1,2,4-oxadiazol til terapi for suppression af nonsens-mutation DK2073805T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85145006P 2006-10-12 2006-10-12
PCT/US2007/021921 WO2008045566A1 (en) 2006-10-12 2007-10-11 Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy

Publications (1)

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DK2073805T3 true DK2073805T3 (da) 2015-06-15

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DK07852738.9T DK2073805T3 (da) 2006-10-12 2007-10-11 Fremgangsmåder til dosering af en oralt aktiv 1,2,4-oxadiazol til terapi for suppression af nonsens-mutation

Country Status (24)

Country Link
US (7) US9226919B2 (da)
EP (2) EP2460520B1 (da)
JP (4) JP2010506840A (da)
KR (4) KR20090074231A (da)
CN (2) CN101553226B (da)
AU (1) AU2007308067B2 (da)
BR (2) BRPI0719276A2 (da)
CA (1) CA2675518C (da)
CL (1) CL2007002923A1 (da)
DK (1) DK2073805T3 (da)
ES (1) ES2538359T3 (da)
HK (2) HK1136214A1 (da)
HR (1) HRP20150590T1 (da)
IL (2) IL198147A (da)
MX (1) MX2009003909A (da)
NO (1) NO342061B1 (da)
PE (4) PE20080982A1 (da)
PL (1) PL2073805T3 (da)
PT (1) PT2073805E (da)
RS (1) RS54025B1 (da)
RU (1) RU2462247C2 (da)
SI (1) SI2073805T1 (da)
TW (1) TWI405570B (da)
WO (1) WO2008045566A1 (da)

Families Citing this family (15)

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ES2624610T3 (es) 2003-04-11 2017-07-17 Ptc Therapeutics, Inc. Compuestos de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades
CN101505739A (zh) * 2006-03-30 2009-08-12 Ptc医疗公司 由具有无义突变的dna生产功能蛋白的方法以及相关疾病的治疗
DK2073805T3 (da) 2006-10-12 2015-06-15 Ptc Therapeutics Inc Fremgangsmåder til dosering af en oralt aktiv 1,2,4-oxadiazol til terapi for suppression af nonsens-mutation
ES2841809T3 (es) 2011-06-03 2021-07-09 Eisai R&D Man Co Ltd Biomarcadores para pronosticar y evaluar el grado de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
CN106455571A (zh) * 2014-03-06 2017-02-22 Ptc医疗公司 1,2,4‑噁二唑苯甲酸的药物组合物和盐
ES2926687T3 (es) 2014-08-28 2022-10-27 Eisai R&D Man Co Ltd Derivado de quinolina muy puro y método para su producción
HUE064614T2 (hu) 2015-02-25 2024-04-28 Eisai R&D Man Co Ltd Eljárás egy kinolin-származék keserû ízének elnyomására
AU2016279474B2 (en) 2015-06-16 2021-09-09 Eisai R&D Management Co., Ltd. Anticancer agent
AR106530A1 (es) 2015-10-30 2018-01-24 Ptc Therapeutics Inc Métodos para tratar epilepsia
TWI801438B (zh) 2017-10-19 2023-05-11 中國大陸商軒竹（北京）醫藥科技有限公司 抗菌胺基糖苷類似物之合成
EP3713934B1 (en) 2017-11-23 2022-04-13 Universita' degli Studi di Palermo Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations
KR102378381B1 (ko) * 2021-08-23 2022-03-24 라이보텍(주) 넌센스-매개 mRNA 분해를 억제하기 위한 화합물
WO2022177269A1 (ko) * 2021-02-16 2022-08-25 라이보텍(주) 넌센스-매개 mrna 분해를 억제하기 위한 화합물
WO2022241030A1 (en) * 2021-05-11 2022-11-17 Regenxbio Inc. Treatment of duchenne muscular dystrophy and combinations thereof
KR102665711B1 (ko) * 2021-12-21 2024-05-14 재단법인 아산사회복지재단 Ras 활성도를 이용한 신경섬유종증 치료제에 대한 감수성 예측용 바이오마커 조성물 및 Ras 활성 억제제를 포함하는 신경섬유종증 예방 또는 치료용 약학적 조성물

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DK2073805T3 (da) 2006-10-12 2015-06-15 Ptc Therapeutics Inc Fremgangsmåder til dosering af en oralt aktiv 1,2,4-oxadiazol til terapi for suppression af nonsens-mutation

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RU2462247C2 (ru) 2012-09-27
EP2460520A1 (en) 2012-06-06
KR20150064244A (ko) 2015-06-10
IL236519A (en) 2017-03-30
US9226919B2 (en) 2016-01-05
US20170049752A1 (en) 2017-02-23
PE20212245A1 (es) 2021-11-24
IL198147A0 (en) 2009-12-24
US20170304275A1 (en) 2017-10-26
TW200820968A (en) 2008-05-16
JP2010506840A (ja) 2010-03-04
WO2008045566B1 (en) 2008-06-19
CN103211766A (zh) 2013-07-24
AU2007308067A1 (en) 2008-04-17
KR20160128468A (ko) 2016-11-07
JP6129713B2 (ja) 2017-05-17
CA2675518C (en) 2017-11-14
KR101758341B1 (ko) 2017-07-14
CA2675518A1 (en) 2008-04-17
US20080114039A1 (en) 2008-05-15
CN101553226A (zh) 2009-10-07
CL2007002923A1 (es) 2008-06-06
US9737513B2 (en) 2017-08-22
US20190099405A1 (en) 2019-04-04
SI2073805T1 (sl) 2015-10-30
PT2073805E (pt) 2015-07-13
IL198147A (en) 2016-02-29
BRPI0719276A2 (pt) 2014-04-29
JP2016029078A (ja) 2016-03-03
EP2073805B1 (en) 2015-03-04
EP2460520B1 (en) 2015-09-30
CN101553226B (zh) 2015-05-13
MX2009003909A (es) 2009-05-25
TWI405570B (zh) 2013-08-21
KR20170100072A (ko) 2017-09-01
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EP2073805A1 (en) 2009-07-01
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