IN2014KN02410A - - Google Patents

Info

Publication number
IN2014KN02410A
IN2014KN02410A IN2410KON2014A IN2014KN02410A IN 2014KN02410 A IN2014KN02410 A IN 2014KN02410A IN 2410KON2014 A IN2410KON2014 A IN 2410KON2014A IN 2014KN02410 A IN2014KN02410 A IN 2014KN02410A
Authority
IN
India
Prior art keywords
compounds
kinases
study
methods
relates
Prior art date
Application number
Other languages
English (en)
Inventor
John Robert Pollard
Philip Michael Reaper
------
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of IN2014KN02410A publication Critical patent/IN2014KN02410A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IN2410KON2014 2012-04-05 2013-04-05 IN2014KN02410A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261620717P 2012-04-05 2012-04-05
PCT/US2013/035466 WO2013152298A1 (fr) 2012-04-05 2013-04-05 Composés utiles comme inhibiteurs d'atr kinase et thérapies combinées les utilisant

Publications (1)

Publication Number Publication Date
IN2014KN02410A true IN2014KN02410A (fr) 2015-05-01

Family

ID=48614105

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2410KON2014 IN2014KN02410A (fr) 2012-04-05 2013-04-05

Country Status (22)

Country Link
US (4) US20140044802A1 (fr)
EP (2) EP3311816A1 (fr)
JP (4) JP2015515478A (fr)
CN (2) CN104582795B (fr)
AU (2) AU2013243291B2 (fr)
CA (1) CA2869309C (fr)
DK (1) DK2833973T3 (fr)
ES (1) ES2654670T3 (fr)
HK (1) HK1205028A1 (fr)
HR (1) HRP20171915T1 (fr)
HU (1) HUE035253T2 (fr)
IN (1) IN2014KN02410A (fr)
LT (1) LT2833973T (fr)
MX (1) MX358818B (fr)
NO (1) NO2885404T3 (fr)
NZ (3) NZ726671A (fr)
PL (1) PL2833973T3 (fr)
PT (1) PT2833973T (fr)
RS (1) RS56673B1 (fr)
SI (1) SI2833973T1 (fr)
TW (2) TW201740949A (fr)
WO (1) WO2013152298A1 (fr)

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CA3013000C (fr) 2008-12-19 2022-12-13 Vertex Pharmaceuticals Incorporated Derives pyrazines utiles en tant qu'inhibiteurs d'atr kinase
US9334244B2 (en) 2010-05-12 2016-05-10 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
NZ603477A (en) 2010-05-12 2014-09-26 Vertex Pharma Compounds useful as inhibitors of atr kinase
EP3878851A1 (fr) 2011-09-30 2021-09-15 Vertex Pharmaceuticals Incorporated Procédé de préparation de composés utiles en tant qu'inhibiteurs de kinase d'atr
CN103957917A (zh) 2011-09-30 2014-07-30 沃泰克斯药物股份有限公司 用atr抑制剂治疗胰腺癌和非小细胞肺癌
HK1205028A1 (en) 2012-04-05 2015-12-11 沃泰克斯药物股份有限公司 Compounds useful as inhibitors of atr kinase and combination therapies thereof
EP2904406B1 (fr) 2012-10-04 2018-03-21 Vertex Pharmaceuticals Incorporated Procédée pour la détermination de dommage de adn augmenté par inhibition de atr
HRP20180859T1 (hr) 2012-12-07 2018-07-13 Vertex Pharmaceuticals Incorporated 2-amino-6-fluoro-n-(5-fluoro-4-(4-(4-(oksetan-3-il)piperazin-1-karbonil)piperidin-1-il)piridin-3-il)pirazolo[1,5alfa]pirimidin-3-karboksamid kao inhibitor atr kinaze
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EP3152212B9 (fr) 2014-06-05 2020-05-27 Vertex Pharmaceuticals Inc. Dérivés radiomarqués d'un composé 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]-pyrazolo[1,5-a]pyrimidine-3-carboxamide utile comme inhibiteur de la kinase atr, préparation dudit composé, et différentes formes solides associées
EP3157566B1 (fr) 2014-06-17 2019-05-01 Vertex Pharmaceuticals Incorporated Méthode de traitement anticancéreux utilisant une association d'inhibiteurs de chk1 et d'atr
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CN113209033A (zh) 2014-08-22 2021-08-06 克洛维斯肿瘤有限公司 Rucaparib的高剂量强度片剂
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EP3661560B1 (fr) 2017-08-04 2025-02-26 Bayer Pharma Aktiengesellschaft Combinaison d'inhibiteurs de kinase atr et d'inhibiteurs de pd-1/pd-l1
EP3461480A1 (fr) 2017-09-27 2019-04-03 Onxeo Combinaison d'inhibiteurs de point de contrôle du cycle cellulaire de réponse à un dommage à l'adn et de belinostat pour traiter le cancer
CA3084863A1 (fr) 2017-12-08 2019-06-13 Bayer Aktiengesellschaft Marqueurs predictifs pour inhibiteurs d'atr kinase
CN113286614A (zh) 2018-09-26 2021-08-20 默克专利股份有限公司 用于治疗癌症的pd-1拮抗剂、atr抑制剂和铂化物质的组合
US20210369705A1 (en) 2018-10-15 2021-12-02 Merck Patent Gmbh Combination therapy utilizing dna alkylating agents and atr inhibitors
CA3116230A1 (fr) 2018-10-16 2020-04-23 Bayer Aktiengesellschaft Combinaison d'inhibiteurs de kinase atr avec des composes de 2,3-dihydro-imidazo[1,2-c]quinazoline
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US20220249531A1 (en) * 2019-07-26 2022-08-11 Health Research, Inc. Treatment of p53-deficient cancers
WO2022103827A1 (fr) * 2020-11-10 2022-05-19 New Mexico Tech University Research Park Corporation Dommage à l'adn induit par kp372-1 en tant qu'approche chimiothérapeutique pour traiter le cancer
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AU2013243291B2 (en) 2018-02-01
HK1206298A1 (en) 2016-01-08
ES2654670T3 (es) 2018-02-14
MX358818B (es) 2018-09-05
CN108478577A (zh) 2018-09-04
JP6770490B2 (ja) 2020-10-14
DK2833973T3 (en) 2018-01-02
LT2833973T (lt) 2018-02-12
CN104582795B (zh) 2018-04-20
JP2018150379A (ja) 2018-09-27
EP2833973A1 (fr) 2015-02-11
CA2869309C (fr) 2021-02-09
NO2885404T3 (fr) 2018-09-22
JP2020196748A (ja) 2020-12-10
CN104582795A (zh) 2015-04-29
HRP20171915T1 (hr) 2018-02-09
US20140044802A1 (en) 2014-02-13
NZ726671A (en) 2018-04-27
SI2833973T1 (en) 2018-04-30
TW201406375A (zh) 2014-02-16
TWI644672B (zh) 2018-12-21

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