WO2002080899A1 - Agent de traitement de maladie digestive - Google Patents
Agent de traitement de maladie digestive Download PDFInfo
- Publication number
- WO2002080899A1 WO2002080899A1 PCT/JP2002/003006 JP0203006W WO02080899A1 WO 2002080899 A1 WO2002080899 A1 WO 2002080899A1 JP 0203006 W JP0203006 W JP 0203006W WO 02080899 A1 WO02080899 A1 WO 02080899A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkylene
- hydrocarbon group
- digestive disease
- aromatic hydrocarbon
- remedial agent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002578938A JPWO2002080899A1 (ja) | 2001-03-30 | 2002-03-27 | 消化器疾患治療剤 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001-101465 | 2001-03-30 | ||
JP2001101465 | 2001-03-30 | ||
JP2001105131 | 2001-04-03 | ||
JP2001-105131 | 2001-04-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002080899A1 true WO2002080899A1 (fr) | 2002-10-17 |
Family
ID=26612853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/003006 WO2002080899A1 (fr) | 2001-03-30 | 2002-03-27 | Agent de traitement de maladie digestive |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPWO2002080899A1 (fr) |
WO (1) | WO2002080899A1 (fr) |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002100813A2 (fr) * | 2001-06-07 | 2002-12-19 | Eli Lilly And Company | Modulateurs de recepteurs actives par le proliferateur de peroxysome |
EP1348698A4 (fr) * | 2000-12-05 | 2005-01-19 | Kyorin Seiyaku Kk | Derives de l'acide carboxylique substitues |
US7244861B2 (en) | 2001-03-30 | 2007-07-17 | Eisai Co., Ltd. | Benzene compound and salt thereof |
WO2008004341A1 (fr) * | 2006-07-03 | 2008-01-10 | The University Of Tokyo | DÉRIVÉS DE L'ACIDE PHÉNYLPROPIONIQUE SUBSTITUÉS EN α |
US7371777B2 (en) | 2001-08-17 | 2008-05-13 | Eisai Co., Ltd. | Cyclic compound and PPAR agonist |
US7544835B2 (en) | 2001-04-20 | 2009-06-09 | Eisai R&D Management Co., Ltd. | Carboxylic acid derivative and salt thereof |
JP2009522255A (ja) * | 2005-12-30 | 2009-06-11 | エスケー ホルディングス カンパニー リミテッド | イソキサゾール誘導体及びその使用 |
WO2010058858A1 (fr) * | 2008-11-21 | 2010-05-27 | ラクオリア創薬株式会社 | Nouveau dérivé de pyrazole-3-carboxamide doté d’une activité antagoniste du récepteur 5-ht2b |
US7943612B2 (en) | 2006-03-09 | 2011-05-17 | High Point Pharmaceuticals, Llc | Compounds that modulate PPAR activity, their preparation and use |
US7943669B2 (en) | 2005-06-30 | 2011-05-17 | High Point Pharmaceuticals, Llc | Phenoxy acetic acids as PPAR delta activators |
US7943613B2 (en) | 2005-12-22 | 2011-05-17 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
US7968723B2 (en) | 2004-05-05 | 2011-06-28 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
US8053598B2 (en) | 2004-05-05 | 2011-11-08 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
JP2014532054A (ja) * | 2011-09-30 | 2014-12-04 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な化合物を作製するためのプロセス |
US9394287B2 (en) | 2010-11-05 | 2016-07-19 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
US9630956B2 (en) | 2010-05-12 | 2017-04-25 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
US9701674B2 (en) | 2008-12-19 | 2017-07-11 | Vertex Pharmaceuticals Incorporated | Substituted pyrazines as ATR kinase inhibitors |
US9732071B2 (en) | 2015-10-01 | 2017-08-15 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
US9791456B2 (en) | 2012-10-04 | 2017-10-17 | Vertex Pharmaceuticals Incorporated | Method for measuring ATR inhibition mediated increases in DNA damage |
US10144731B2 (en) | 2013-12-18 | 2018-12-04 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
US10272095B2 (en) | 2015-06-15 | 2019-04-30 | GlaxoSmithKline Intellectual Propert Development Limited | NRF2 regulators |
US10364256B2 (en) | 2015-10-06 | 2019-07-30 | Glaxosmithkline Intellectual Property Development Limited | Biaryl pyrazoles as NRF2 regulators |
US10478430B2 (en) | 2012-04-05 | 2019-11-19 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase and combination therapies thereof |
US10604509B2 (en) | 2015-06-15 | 2020-03-31 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
JP2020514364A (ja) * | 2017-03-14 | 2020-05-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Phgdh阻害薬としてのトシルアセタートベース化合物及びその誘導体 |
WO2020153414A1 (fr) | 2019-01-24 | 2020-07-30 | 武田薬品工業株式会社 | Composé hétérocyclique et son utilisation |
US10813929B2 (en) | 2011-09-30 | 2020-10-27 | Vertex Pharmaceuticals Incorporated | Treating cancer with ATR inhibitors |
CN113717045A (zh) * | 2021-10-11 | 2021-11-30 | 梧州学院 | 一种对羟基苯甲酸铜(ii)配合物及其合成方法和应用 |
US11464774B2 (en) | 2015-09-30 | 2022-10-11 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998043081A1 (fr) * | 1997-03-26 | 1998-10-01 | Ligand Pharmaceuticals Incorporated | Traitement de troubles gastro-intestinaux au moyen de modulateurs du recepteur active de la proliferation des peroxysomes (ppar) |
WO2000075103A1 (fr) * | 1999-06-09 | 2000-12-14 | Kyorin Pharmaceutical Co., Ltd. | DERIVES D'ACIDE PHENYLPROPIONIQUE SUBSTITUES COMME AGONISTES DU RECEPTEUR HUMAIN ACTIVE DE LA PROLIFERATION DES PEROXYSOMES (PPAR) $g(a) |
WO2001021578A1 (fr) * | 1999-09-17 | 2001-03-29 | Kyorin Pharmaceutical Co., Ltd. | Derives d'o-anisamide |
WO2001025181A1 (fr) * | 1999-10-01 | 2001-04-12 | Eisai Co., Ltd. | Derives d'acide carboxylique et medicaments les contenant |
-
2002
- 2002-03-27 JP JP2002578938A patent/JPWO2002080899A1/ja active Pending
- 2002-03-27 WO PCT/JP2002/003006 patent/WO2002080899A1/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998043081A1 (fr) * | 1997-03-26 | 1998-10-01 | Ligand Pharmaceuticals Incorporated | Traitement de troubles gastro-intestinaux au moyen de modulateurs du recepteur active de la proliferation des peroxysomes (ppar) |
WO2000075103A1 (fr) * | 1999-06-09 | 2000-12-14 | Kyorin Pharmaceutical Co., Ltd. | DERIVES D'ACIDE PHENYLPROPIONIQUE SUBSTITUES COMME AGONISTES DU RECEPTEUR HUMAIN ACTIVE DE LA PROLIFERATION DES PEROXYSOMES (PPAR) $g(a) |
WO2001021578A1 (fr) * | 1999-09-17 | 2001-03-29 | Kyorin Pharmaceutical Co., Ltd. | Derives d'o-anisamide |
WO2001025181A1 (fr) * | 1999-10-01 | 2001-04-12 | Eisai Co., Ltd. | Derives d'acide carboxylique et medicaments les contenant |
Cited By (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1348698A4 (fr) * | 2000-12-05 | 2005-01-19 | Kyorin Seiyaku Kk | Derives de l'acide carboxylique substitues |
US7244861B2 (en) | 2001-03-30 | 2007-07-17 | Eisai Co., Ltd. | Benzene compound and salt thereof |
EP1375472A4 (fr) * | 2001-03-30 | 2008-12-10 | Eisai R&D Man Co Ltd | Compose de benzene et sel de ce compose |
US7544835B2 (en) | 2001-04-20 | 2009-06-09 | Eisai R&D Management Co., Ltd. | Carboxylic acid derivative and salt thereof |
WO2002100813A3 (fr) * | 2001-06-07 | 2003-11-27 | Lilly Co Eli | Modulateurs de recepteurs actives par le proliferateur de peroxysome |
WO2002100813A2 (fr) * | 2001-06-07 | 2002-12-19 | Eli Lilly And Company | Modulateurs de recepteurs actives par le proliferateur de peroxysome |
US7371777B2 (en) | 2001-08-17 | 2008-05-13 | Eisai Co., Ltd. | Cyclic compound and PPAR agonist |
US7968723B2 (en) | 2004-05-05 | 2011-06-28 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
US8053598B2 (en) | 2004-05-05 | 2011-11-08 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
US7943669B2 (en) | 2005-06-30 | 2011-05-17 | High Point Pharmaceuticals, Llc | Phenoxy acetic acids as PPAR delta activators |
US8426473B2 (en) | 2005-06-30 | 2013-04-23 | High Point Pharnaceuticals, LLC | Phenoxy acetic acids as PPAR delta activators |
US8217086B2 (en) | 2005-06-30 | 2012-07-10 | High Point Pharmaceuticals, Llc | Phenoxy acetic acids as PPAR delta activators |
US7943613B2 (en) | 2005-12-22 | 2011-05-17 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
US8551993B2 (en) | 2005-12-22 | 2013-10-08 | High Point Pharmaceuticals, Llc | Phenoxy acetic acids as PPAR delta activators |
US9855274B2 (en) | 2005-12-22 | 2018-01-02 | Vtv Therapeutics Llc | Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists |
US10471066B2 (en) | 2005-12-22 | 2019-11-12 | Vtv Therapeutics Llc | Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists |
US9663481B2 (en) | 2005-12-22 | 2017-05-30 | Vtv Therapeutics Llc | Phenoxy acetic acids and phenyl propionic acids as PPARδ agonists |
US10947180B2 (en) | 2005-12-22 | 2021-03-16 | Vtv Therapeutics Llc | Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists |
US11420929B2 (en) | 2005-12-22 | 2022-08-23 | Vtv Therapeutics Llc | Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists |
US8362016B2 (en) | 2005-12-22 | 2013-01-29 | High Point Pharmaceuticals, Llc | Phenyl propionic acids as PPAR delta activators |
JP2009522255A (ja) * | 2005-12-30 | 2009-06-11 | エスケー ホルディングス カンパニー リミテッド | イソキサゾール誘導体及びその使用 |
US7943612B2 (en) | 2006-03-09 | 2011-05-17 | High Point Pharmaceuticals, Llc | Compounds that modulate PPAR activity, their preparation and use |
JPWO2008004341A1 (ja) * | 2006-07-03 | 2009-12-03 | 国立大学法人 東京大学 | α−置換フェニルプロピオン酸誘導体 |
JP5147071B2 (ja) * | 2006-07-03 | 2013-02-20 | 国立大学法人 東京大学 | α−置換フェニルプロピオン酸誘導体 |
WO2008004341A1 (fr) * | 2006-07-03 | 2008-01-10 | The University Of Tokyo | DÉRIVÉS DE L'ACIDE PHÉNYLPROPIONIQUE SUBSTITUÉS EN α |
JP5621148B2 (ja) * | 2008-11-21 | 2014-11-05 | ラクオリア創薬株式会社 | 5−ht2b受容体拮抗活性を有する新規ピラゾール−3−カルボキサミド誘導体 |
US8252790B2 (en) | 2008-11-21 | 2012-08-28 | Raqualia Pharma Inc. | Pyrazole-3-carboxamide derivative having 5-HT2B receptor antagonist activity |
KR101637337B1 (ko) | 2008-11-21 | 2016-07-07 | 라퀄리아 파마 인코포레이티드 | 5-ht2b 수용체 길항활성을 가지는 신규 피라졸-3-카복사미드 유도체 |
WO2010058858A1 (fr) * | 2008-11-21 | 2010-05-27 | ラクオリア創薬株式会社 | Nouveau dérivé de pyrazole-3-carboxamide doté d’une activité antagoniste du récepteur 5-ht2b |
CN102224142A (zh) * | 2008-11-21 | 2011-10-19 | 拉夸里亚创药株式会社 | 具有5-ht2b受体拮抗活性的新型吡唑-3-羧酰胺衍生物 |
KR20110091550A (ko) * | 2008-11-21 | 2011-08-11 | 라퀄리아 파마 인코포레이티드 | 5-ht2b 수용체 길항활성을 가지는 신규 피라졸-3-카복사미드 유도체 |
US10479784B2 (en) | 2008-12-19 | 2019-11-19 | Vertex Pharmaceuticals Incorporated | Substituted pyrazin-2-amines as inhibitors of ATR kinase |
US9701674B2 (en) | 2008-12-19 | 2017-07-11 | Vertex Pharmaceuticals Incorporated | Substituted pyrazines as ATR kinase inhibitors |
US10961232B2 (en) | 2008-12-19 | 2021-03-30 | Vertex Pharmaceuticals Incorporated | Substituted pyrazines as ATR kinase inhibitors |
US9630956B2 (en) | 2010-05-12 | 2017-04-25 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
US10953007B2 (en) | 2010-11-05 | 2021-03-23 | Firmenich Incorporated | Compounds useful as modulators of TRPM8 |
US9394287B2 (en) | 2010-11-05 | 2016-07-19 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
US10016418B2 (en) | 2010-11-05 | 2018-07-10 | Seaomyx, Inc. | Compounds useful as modulators of TRPM8 |
US10208027B2 (en) | 2011-09-30 | 2019-02-19 | Vertex Pharmaceuticals Incorporated | Processes for preparing ATR inhibitors |
JP2014532054A (ja) * | 2011-09-30 | 2014-12-04 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な化合物を作製するためのプロセス |
US9862709B2 (en) | 2011-09-30 | 2018-01-09 | Vertex Pharmaceuticals Incorporated | Processes for making compounds useful as inhibitors of ATR kinase |
US10822331B2 (en) | 2011-09-30 | 2020-11-03 | Vertex Pharmaceuticals Incorporated | Processes for preparing ATR inhibitors |
JP2017226676A (ja) * | 2011-09-30 | 2017-12-28 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な化合物を作製するためのプロセス |
US10813929B2 (en) | 2011-09-30 | 2020-10-27 | Vertex Pharmaceuticals Incorporated | Treating cancer with ATR inhibitors |
US10478430B2 (en) | 2012-04-05 | 2019-11-19 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase and combination therapies thereof |
US11110086B2 (en) | 2012-04-05 | 2021-09-07 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase and combination therapies thereof |
US9791456B2 (en) | 2012-10-04 | 2017-10-17 | Vertex Pharmaceuticals Incorporated | Method for measuring ATR inhibition mediated increases in DNA damage |
US10144731B2 (en) | 2013-12-18 | 2018-12-04 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
US10604509B2 (en) | 2015-06-15 | 2020-03-31 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
US10485806B2 (en) | 2015-06-15 | 2019-11-26 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
US10272095B2 (en) | 2015-06-15 | 2019-04-30 | GlaxoSmithKline Intellectual Propert Development Limited | NRF2 regulators |
US11464774B2 (en) | 2015-09-30 | 2022-10-11 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors |
US9732071B2 (en) | 2015-10-01 | 2017-08-15 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
US10364256B2 (en) | 2015-10-06 | 2019-07-30 | Glaxosmithkline Intellectual Property Development Limited | Biaryl pyrazoles as NRF2 regulators |
US11304929B2 (en) | 2017-03-14 | 2022-04-19 | Boehringer Ingelheim International Gmbh | Tosylacetate based compounds and derivatives thereof as PHGDH inhibitors |
JP2020514364A (ja) * | 2017-03-14 | 2020-05-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Phgdh阻害薬としてのトシルアセタートベース化合物及びその誘導体 |
WO2020153414A1 (fr) | 2019-01-24 | 2020-07-30 | 武田薬品工業株式会社 | Composé hétérocyclique et son utilisation |
CN113717045A (zh) * | 2021-10-11 | 2021-11-30 | 梧州学院 | 一种对羟基苯甲酸铜(ii)配合物及其合成方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
JPWO2002080899A1 (ja) | 2005-01-06 |
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