HRP20151143T1 - Novi antimalarijski agensi - Google Patents

Novi antimalarijski agensi Download PDF

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HRP20151143T1
HRP20151143T1 HRP20151143TT HRP20151143T HRP20151143T1 HR P20151143 T1 HRP20151143 T1 HR P20151143T1 HR P20151143T T HRP20151143T T HR P20151143TT HR P20151143 T HRP20151143 T HR P20151143T HR P20151143 T1 HRP20151143 T1 HR P20151143T1
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pyridin
phenyl
amine
methylsulfonyl
amino
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HRP20151143TT
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Michael John Witty
David Hardick
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Mmv Medicines For Malaria Venture
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A—HUMAN NECESSITIES
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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Claims (16)

1. Aminopiridin prema formuli (I), [image] naznačen time, da su X i Y neovisno odabrani između opcionalno supstituiranog arila i opcionalno supstituiranog heteroarila, kao i njihovih tautomera, geometrijskih izomera, optički aktivnih oblika, farmaceutski prihvatljivih soli, kompleksa i farmaceutski aktivnih derivata za upotrebu u liječenju ili profilaksi malarije.
2. Aminopiridin za upotrebu prema patentnom zahtjevu 1, naznačen time da je X opcionalno supstituiran aril.
3. Aminopiridin za upotrebu prema patentnom zahtjevu 2, naznačen time da je X opcionalno supstituiran fenil.
4. Aminopiridin za upotrebu prema patentnom zahtjevu 1, naznačen time da je X opcionalno supstituiran heteroaril.
5. Aminopiridin za upotrebu prema bilo kojem od patentnih zahtjeva od 1 do 4, naznačen time da je Y opcionalno supstituiran aril.
6. Aminopiridin za upotrebu prema bilo kojem od patentnih zahtjeva od 1 do 4, naznačen time da je Y opcionalno supstituiran heteroaril.
7. Aminopiridin za upotrebu prema patentnom zahtjevu 6, naznačen time da je Y opcionalno supstituiran piridin.
8. Aminopiridin za upotrebu prema bilo kojem od patentnih zahtjeva od 1 do 3, naznačen time da je X opcionalno supstituiran fenil odabran iz grupe koju čine opcionalno supstituirana C1-C6 alkil sulfonil fenil, opcionalno supstituirana sulfonamid fenil, opcionalno supstituirana fenil amid i opcionalno supstituirana karbonil fenil grupa.
9. Aminopiridin za upotrebu prema patentnom zahtjevu 1, naznačen time da je X opcionalno supstituiran fenil odabran iz grupe koju čine opcionalno supstituirana sulfonil fenil, opcionalno supstituirana fenil amid i opcionalno supstituirana amid karbonil fenil grupa i da je Y opcionalno supstituiran piridin.
10. Aminopiridin za upotrebu prema bilo kojem od patentnih zahtjeva od 1 do 9, naznačen time da je aminopiridin odabran iz grupe koja slijedi: 3-(6-metoksipiridin-3-il)-5-(4-metilsulfonilfenil)piridin-2-amin; 5-(4-metilsulfonilfenil)-3-[3-(trifluorometil)fenil]piridin-2-amin; 3-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]fenol; 4-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]-2-metoksifenol; 4-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]fenol; 4-[2-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-2-metoksifenol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]-2,6-dimetilfenol; [4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]fenil]metanol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]fenol; (N,N-dimetil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N,N-dimetil benzamid; 5-(2-metoksipiridin-5-il)-3-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(pirimidin-5-il)piridin-2-amin; (morfolino){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 3,5-di(2-metoksipiridin-5-il)piridin-2-amin; (N-metil piperazin){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 3,5-di-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-[3-(metilsulfonil)fenil]piridin-2-amin; (N-metil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-metilbenzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzamid; 4-[6-amino-5-(2-metoksipiridin-5-il)piridin-3-il]benzojeva kiselina; N{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}metil sulfonamid; 4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-N-(3-hidroksipropil)-benzamid; 5-(benzo[c][[1,2,5]oksadiazol-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; N-ciklopropil-{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 5-(H-imidazo[1,2-a]piridin-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-3-il)-5-(1-metil-1H-indazol-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-ciklopropilbenzamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-(2-morfolino etil) benzamid; 3-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzamid; 3-(2-metoksipiridin-5-il)-5-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(6-morfolinopiridin-3-il)piridin-2-amin; 5-[4-(1H-pirazol-1-il)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(kinolin-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-[2-(pirolidin-1-il)etil]benzamid; 5-[2-(trifluoro metil)-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; {4-[2-amino-3-(4-karbamoilfenil)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metilpiridin-5-il)piridin-5-il]benzamid; [4-(2-amino-5-metilpiridin-3-il)-N-(2-hidroksietil) benzamido](morfolino) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzensulfonamid; 4-[2-amin-3-(4-benzamido)piridin-5-il]benzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(4-metilpiperazin-1-il) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-[4-(aminometil)tiazol-2-il]benzamid; {4-[2-amino-3-(4-(trifluorometil)fenil)piridin-5-il]fenil}(morfolino)metanon; 3-(2-metoksipiridin-3-il)-5-[4-(metilsulfonilfenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(piridin-3-il)piridin-2-amin; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}-N-metilbenzamid; 3-(H-imidazo[1,2-a]piridin-6-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksipirimidin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(kinoksalin-7-il)piridin-2-amin; 3-(furan-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-kloro-2-metoksipiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[3-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[4-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(pirolidin-1-il)piridin-5-il]piridin-2-amin; 3-[2-kloro-4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metoksipiridin-4-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(2-morfolino piridin-5-il)piridin-2-amin; 3-[2-(trifluorometil)piridin-4-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metilpiridin-5-il)-5-[4-(metil sulfonil)fenil]piridin-2-amin; 3-[2-(trifluoro-metil)piridin-5-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{4-[2-(pirolidin-1-il) etoksi]fenil}-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(4-morfolinofenil)piridin-2-amin; 3-[4-(1H-pirazol-1-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}pirimidin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 3-(6-metoksi-2-metilpiridin-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(izokinolin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(kinolin-6-il)piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-p-tolilpiridin-2-amin; {5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}metanol; 3-(2-metilbenzo[d]tiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; N{4-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]fenil}-2-(dimetilamino) acetamid; 3-(2-fluorpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(metilsulfonil)piridin-5-il]piridin-2-amin; N{5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}acetamid; 3-(benzo[c][1,2,5]oksadiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il]-N-(2-hidroksietil) benzamid; 3-[4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metilpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; i 5-[3-fluoro-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin.
11. Aminopiridin odabran iz grupe koju čine: 3-(6-metoksipiridin-3-il)-5-(4-metilsulfonilfenil)piridin-2-amin; 5-(4-metilsulfonilfenil)-3-[3-(trifluorometil)fenil]piridin-2-amin; 3-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]fenol; 4-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]-2-metoksifenol; 4-[2-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-2-metoksifenol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]-2,6-dimetilfenol; [4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]fenil]metanol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]fenol; (N,N-dimetil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N,N-dimetil benzamid; 5-(2-metoksipiridin-5-il)-3-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(pirimidin-5-il)piridin-2-amin; (morfolino){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; (N-metil piperazin){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 3,5-di-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-[3-(metil sulfonil)fenil]piridin-2-amin; (N-metil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-metilbenzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzamid; 4-[6-amino-5-(2-metoksipiridin-5-il)piridin-3-il]benzojeva kiselina; N{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}metil sulfonamid; 4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-N-(3-hidroksipropil)-benzamid; 5-(benzo[c][1,2,5]oksadiazol-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; N-ciklopropil-{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 5-(H-imidazo[1,2-a]piridin-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-3-il)-5-(1-metil-1H-indazol-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N(2-morfolino etil) benzamid; 3-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzamid; 3-(2-metoksipiridin-5-il)-5-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(6-morfolinopiridin-3-il)piridin-2-amin; 5-[4-(1H-pirazol-1-il)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(kinolin-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-[2-(pirolidin-1-il) etil]benzamid; 5-[2-(trifluoro metil)-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; {4-[2-amino-3-(4-karbamoil fenil)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metilpiridin-5-il)piridin-5-il]benzamid; [4-(2-amino-5-metilpiridin-3-il)-N-(2-hidroksietil)benzamido](morfolino) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5 il]benzen sulfonamid; 4-[2-amino-3-(4-benzamido)piridin-5-il]benzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(4-metilpiperazin-1-il) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N[4-(aminometil) tiazol-2-il]benzamid; {4-[2-amino-3-(4-(trifluorometil)fenil)piridin-5-il]fenil}(morfolino)metanon; 3-(2-metoksipiridin-3-il)-5-[4-(metil sulfonil fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(piridin-3-il)piridin-2-amin; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}-N-metilbenzamid; 3-(H-imidazo[1,2-a]piridin-6-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksi pirimidin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(kinoksalin-7-il)piridin-2-amin; 3-(furan-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-kloro-2-metoksipiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[3-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[4-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(pirolidin-1-il)piridin-5-il]piridin-2-amin; 3-[2-kloro-4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metoksipiridin-4-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(2-morfolino piridin-5-il)piridin-2-amin; 3-[2-(trifluorometil)piridin-4-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metilpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-[2-(trifluoro-metil)piridin-5-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{4-[2-(pirolidin-1-il) etoksi]fenil}-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(4-morfolinofenil)piridin-2-amin; 3-[4-(1H-pirazol-1-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}pirimidin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 3-(6-metoksi-2-metilpiridin-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(izokinolin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(kinolin-6-il)piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-p-tolilpiridin-2-amin; {5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}metanol; 3-(2-metilbenzo[d]tiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; N-{4-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]fenil}-2-(dimetilamino)acetamid; 3-(2-fluorpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(metilsulfonil)piridin-5-il]piridin-2-amin; N-{5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}acetamid; 3-(benzo[c][1,2,5]oksadiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il]-N-(2-hidroksietil) benzamid; 3-[4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metilpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; i 5-[3-fluoro-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin.
12. Aminopiridin opisan u patentnom zahtjevu 10 za upotrebu u vidu medikamenta, odabran iz grupe koju čine: 3-(6-metoksipiridin-3-il)-5-(4-metilsulfonilfenil)piridin-2-amin; 5-(4-metilsulfonilfenil)-3-[3-(trifluorometil)fenil]piridin-2-amin; 3-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]fenol; 4-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]-2-metoksifenol; 4-[2-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-2-metoksifenol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]-2,6-dimetilfenol; [4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]fenil]metanol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]fenol; (N,N-dimetil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N,N-dimetil benzamid; 5-(2-metoksipiridin-5-il)-3-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(pirimidin-5-il)piridin-2-amin; (morfolino){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 3,5-di(2-metoksipiridin-5-il)piridin-2-amin; (N-metil piperazin){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 3,5-di-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-[3-(metil sulfonil)fenil]piridin-2-amin; (N-metil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-metilbenzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzamid; 4-[6-amino-5-(2-metoksipiridin-5-il)piridin-3-il]benzojeva kiselina; N-{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}metil sulfonamid; 4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-N-(3-hidroksipropil)-benzamid; 5-(benzo[c][1,2,5]oksadiazol-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; N-ciklopropil-{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 5-(H-imidazo[1,2-a]piridin-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-3-il)-5-(1-metil-1H-indazol-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-(2-morfolinoetil)benzamid; 3-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-benzamid; 3-(2-metoksipiridin-5-il)-5-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(6-morfolinopiridin-3-il)piridin-2-amin; 5-[4-(1H-pirazol-1-il)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(kinolin-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N[2-(pirolidin-1-il)etil]benzamid; 5-[2-(trifluoro metil)-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; {4-[2-amino-3-(4-karbamoilfenil)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metilpiridin-5-il)piridin-5-il]benzamid; [4-(2-amino-5-metilpiridin-3-il)-N-(2-hidroksietil)benzamido](morfolino) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen sulfonamid; 4-[2-amino-3-(4-benzamido)piridin-5-il]benzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(4-metilpiperazin-1-il) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N[4-(aminometil)tiazol-2-il]benzamid; {4-[2-amino-3-(4-(trifluorometil)fenil)piridin-5-il]fenil}(morfolino)metanon; 3-(2-metoksipiridin-3-il)-5-[4-(metil sulfonil fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(piridin-3-il)piridin-2-amin; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}-N-metilbenzamid; 3-(H-imidazo[1,2-a]piridin-6-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksi pirimidin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(kinoksalin-7-il)piridin-2-amin; 3-(furan-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-kloro-2-metoksipiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[3-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[4-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(pirolidin-1-il)piridin-5-il]piridin-2-amin; 3-[2-kloro-4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metoksipiridin-4-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(2-morfolinopiridin-5-il)piridin-2-amin; 3-[2-(trifluorometil)piridin-4-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metilpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-[2-(trifluoro-metil)piridin-5-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{4-[2-(pirolidin-1-il)etoksi]fenil}-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(4-morfolinofenil)piridin-2-amin; 3-[4-(1H-pirazol-1-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}pirimidin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 3-(6-metoksi-2-metilpiridin-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(izokinolin-5-il)-5-[4-(metil sulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(kinolin-6-il)piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-p-tolilpiridin-2-amin; {5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}metanol; 3-(2-metilbenzo[d]tiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; N-{4-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]fenil}-2-(dimetilamino)acetamid; 3-(2-fluorpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(metilsulfonil)piridin-5-il]piridin-2-amin; N-{5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}acetamid; 3-(benzo[c][1,2,5]oksadiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il]-N-(2-hidroksietil) benzamid; 3-[4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metilpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; i 5-[3-fluoro-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin.
13. Farmaceutska formulacija koja sadrži najmanje jedan od derivata odabran iz grupe koju čine: 3-(6-metoksipiridin-3-il)-5-(4-metilsulfonilfenil)piridin-2-amin; 5-(4-metilsulfonilfenil)-3-[3-(trifluorometil)fenil]piridin-2-amin; 3-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]fenol; 4-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il)]-2-metoksifenol; 4-[2-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-2-metoksifenol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]-2,6-dimetilfenol; [4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]fenil]metanol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]fenol; (N,N-dimetil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N,N-dimetil benzamid; 5-(2-metoksipiridin-5-il)-3-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(pirimidin-5-il)piridin-2-amin; (morfolino){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 3,5-di(2-metoksipiridin-5-il)piridin-2-amin; (N-metil piperazin){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 3,5-di-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-[3-(metil sulfonil)fenil]piridin-2-amin; (N-metil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-metilbenzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzamid; 4-[6-amino-5-(2-metoksipiridin-5-il)piridin-3-il]benzojeva kiselina; N-{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}metil sulfonamid; 4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-N-(3-hidroksipropil) benzamid; 5-(benzo[c][1,2,5]oksadiazol-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; N-ciklopropil-{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 5-(H-imidazo[1,2-a]piridin-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-3-il)-5-(1-metil-1H-indazol-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-(2-morfolinoetil)benzamid; 3-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzamid; 3-(2-metoksipiridin-5-il)-5-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(6-morfolinopiridin-3-il)piridin-2-amin; 5-[4-(1H-pirazol-1-il)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(kinolin-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N[2-(pirolidin-1-il)etil]benzamid; 5-[2-(trifluorometil)-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; {4-[2-amino-3-(4-karbamoilfenil)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metilpiridin-5-il)piridin-5-il]benzamid; [4-(2-amino-5-metilpiridin-3-il)-N-(2-hidroksietil) benzamido](morfolino) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen sulfonamid 4-[2-amin-3-(4-benzamido)piridin-5-il]benzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(4-metilpiperazin-1-il) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N[4-(aminometil)tiazol-2-il]benzamid; {4-[2-amino-3-(4-(trifluorometil)fenil)piridin-5-il]fenil}(morfolino)metanon; 3-(2-metoksipiridin-3-il)-5-[4-(metilsulfonilfenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(piridin-3-il)piridin-2-amin; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}-N-metilbenzamid; 3-(H-imidazo[1,2-a]piridin-6-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksipirimidin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(kinoksalin-7-il)piridin-2-amin; 3-(furan-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-kloro-2-metoksipiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[3-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[4-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(pirolidin-1-il)piridin-5-il]piridin-2-amin; 3-[2-kloro-4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metoksipiridin-4-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(2-morfolino piridin-5-il)piridin-2-amin; 3-[2-(trifluorometil)piridin-4-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metilpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-[2-(trifluoro-metil)piridin-5-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{4-[2-(pirolidin-1-il)etoksi]fenil}-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(4-morfolinofenil)piridin-2-amin; 3-[4-(1H-pirazol-1-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}pirimidin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 3-(6-metoksi-2-metilpiridin-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(izokinolin-5-il)-5-[4-(metil sulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(kinolin-6-il)piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-p-tolilpiridin-2-amin; {5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}metanol; 3-(2-metilbenzo[d]tiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; N-{4-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]fenil}-2-(dimetilamino) acetamid; 3-(2-fluorpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(metilsulfonil)piridin-5-il]piridin-2-amin; N-{5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}acetamid; 3-(benzo[c][1,2,5]oksadiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il]-N-(2-hidroksietil) benzamid; 3-[4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metilpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; i 5-[3-fluoro-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin i njihovi farmaceutski prihvatljivi nosači, razrjeđivači ili ekscipijensi.
14. Farmaceutska formulacija koji sadrži aminopiridin prema formuli (I) i antimalarijski agens, naznačen time da su X i Y definirani u bilo kojem od prethodnih patentnih zahtjeva.
15. Aminopiridin za upotrebu prema bilo kom od patentnih zahtjeva od 1 do 10, naznačen time da se aminopiridin ili njegova farmaceutska formulacija primjenjuju u kombinaciji sa ko-agensom koji je od koristi u liječenju malarije.
16. Aminopiridin za upotrebu prema patentnom zahtjevu 15, naznačen time da je ko-agens odabran iz grupe koju čine artemeter, klorokin, meflokin, kinin, atovakvon/progvanil, doksiciklin, artesunat, hidroksiklorokin, halofantrin, pirimetamin-sulfadoksin, primakin i piperakin.
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Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201607592PA (en) 2008-12-19 2016-11-29 Vertex Pharma Pyrazine derivatives useful as inhibitors of atr kinase
MX2012013082A (es) * 2010-05-12 2013-05-09 Vertex Pharma Derivados de 2-aminopiridina utiles como iinhibidores de cinasa atr.
JP2013526540A (ja) 2010-05-12 2013-06-24 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
CA2798763A1 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
KR20140014205A (ko) * 2011-03-04 2014-02-05 렉시컨 파마슈티컬스 인코퍼레이티드 Mst1 키나제 억제제 및 그의 사용 방법
WO2013049859A1 (en) 2011-09-30 2013-04-04 Vertex Pharmaceuticals Incorporated Treating pancreatic cancer and non-small cell lung cancer with atr inhibitors
EP2940017B1 (en) 2011-09-30 2019-08-28 Vertex Pharmaceuticals Incorporated Process for making compounds useful as inhibitors of ATR kinase
WO2013121387A1 (en) 2012-02-17 2013-08-22 University Of Cape Town Anti -malarial agents
CN108478577A (zh) 2012-04-05 2018-09-04 沃泰克斯药物股份有限公司 可用作atr激酶抑制剂的化合物及其组合疗法
WO2014055756A1 (en) 2012-10-04 2014-04-10 Vertex Pharmaceuticals Incorporated Method for measuring atr inhibition mediated increases in dna damage
EP2970186B1 (en) * 2013-03-15 2020-06-10 Dow AgroSciences LLC 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic) pyrimidine-4-carboxylates and their use as herbicides
MY184855A (en) 2013-03-15 2021-04-27 Dow Agrosciences Llc 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides
PL3134396T3 (pl) * 2014-04-24 2020-04-30 Novartis Ag Pochodne aminopirydyny jako inhibitory 3-kinazy fosfatydyloinozytolu
BR112016024533A8 (pt) 2014-04-24 2021-03-30 Novartis Ag derivados de amino pirazina como inibidores de fosfatidilinositol 3-cinase ou sal, seu uso, e composição e combinação farmacêuticas
CN106458966B (zh) 2014-04-24 2019-05-07 诺华股份有限公司 作为磷脂酰肌醇3-激酶抑制剂的吡嗪衍生物
JP7109919B2 (ja) * 2015-03-20 2022-08-01 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｕｓｐ７阻害剤化合物及び使用方法
EP3118198A1 (en) 2015-07-13 2017-01-18 MMV Medicines for Malaria Venture Anti-malarial agents
AU2016331955B2 (en) 2015-09-30 2022-07-21 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
WO2017067881A1 (en) * 2015-10-19 2017-04-27 Glaxosmithkline Intellectual Property Development Limited Pyrazine compounds for use in the treatment of parasitic protozoal infections
GB201603104D0 (en) * 2016-02-23 2016-04-06 Ucb Biopharma Sprl Therapeutic agents
EP3254679A1 (de) 2016-06-09 2017-12-13 Christian-Albrechts-Universität zu Kiel Wirkstoffe gegen protozoen und bakterien
JP7446236B2 (ja) * 2017-12-22 2024-03-08 ラヴェンナ ファーマシューティカルズ，インコーポレイテッド ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアリール－ビピリジンアミン誘導体
SI3762368T1 (sl) 2018-03-08 2022-06-30 Incyte Corporation Aminopirazin diolne spojine kot zaviralci PI3K-y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
EP3842100A1 (en) * 2019-12-24 2021-06-30 The Board Of Regents Of The University Of Texas System Anti-malarial agents
WO2024033280A1 (en) 2022-08-09 2024-02-15 Merck Patent Gmbh Furopyridin and furopyrimidin, inhibitors of pi4k, for use in the treatment of parasite infection and malaria
WO2024033281A1 (en) 2022-08-09 2024-02-15 Merck Patent Gmbh Furo pyrimidine derivates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100574350B1 (ko) 2004-08-31 2006-04-27 한국화학연구원 2-아미노피리딘 유도체의 제조방법
JP2009507824A (ja) 2005-09-12 2009-02-26 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ 抗マラリアベイリス−ヒルマン付加物およびその調製方法
EP1900727A1 (en) * 2006-08-30 2008-03-19 Cellzome Ag Aminopyridine derivatives as kinase inhibitors
CN101555248B (zh) 2009-05-22 2011-06-22 北京欧凯纳斯科技有限公司 一种多取代1,5-萘啶化合物的制备方法

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