HRP20151143T1 - Novi antimalarijski agensi - Google Patents

Novi antimalarijski agensi Download PDF

Info

Publication number
HRP20151143T1
HRP20151143T1 HRP20151143TT HRP20151143T HRP20151143T1 HR P20151143 T1 HRP20151143 T1 HR P20151143T1 HR P20151143T T HRP20151143T T HR P20151143TT HR P20151143 T HRP20151143 T HR P20151143T HR P20151143 T1 HRP20151143 T1 HR P20151143T1
Authority
HR
Croatia
Prior art keywords
pyridin
phenyl
amine
methylsulfonyl
amino
Prior art date
Application number
HRP20151143TT
Other languages
English (en)
Inventor
Michael John Witty
David Hardick
Original Assignee
Mmv Medicines For Malaria Venture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mmv Medicines For Malaria Venture filed Critical Mmv Medicines For Malaria Venture
Publication of HRP20151143T1 publication Critical patent/HRP20151143T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Claims (16)

1. Aminopiridin prema formuli (I), [image] naznačen time, da su X i Y neovisno odabrani između opcionalno supstituiranog arila i opcionalno supstituiranog heteroarila, kao i njihovih tautomera, geometrijskih izomera, optički aktivnih oblika, farmaceutski prihvatljivih soli, kompleksa i farmaceutski aktivnih derivata za upotrebu u liječenju ili profilaksi malarije.
2. Aminopiridin za upotrebu prema patentnom zahtjevu 1, naznačen time da je X opcionalno supstituiran aril.
3. Aminopiridin za upotrebu prema patentnom zahtjevu 2, naznačen time da je X opcionalno supstituiran fenil.
4. Aminopiridin za upotrebu prema patentnom zahtjevu 1, naznačen time da je X opcionalno supstituiran heteroaril.
5. Aminopiridin za upotrebu prema bilo kojem od patentnih zahtjeva od 1 do 4, naznačen time da je Y opcionalno supstituiran aril.
6. Aminopiridin za upotrebu prema bilo kojem od patentnih zahtjeva od 1 do 4, naznačen time da je Y opcionalno supstituiran heteroaril.
7. Aminopiridin za upotrebu prema patentnom zahtjevu 6, naznačen time da je Y opcionalno supstituiran piridin.
8. Aminopiridin za upotrebu prema bilo kojem od patentnih zahtjeva od 1 do 3, naznačen time da je X opcionalno supstituiran fenil odabran iz grupe koju čine opcionalno supstituirana C1-C6 alkil sulfonil fenil, opcionalno supstituirana sulfonamid fenil, opcionalno supstituirana fenil amid i opcionalno supstituirana karbonil fenil grupa.
9. Aminopiridin za upotrebu prema patentnom zahtjevu 1, naznačen time da je X opcionalno supstituiran fenil odabran iz grupe koju čine opcionalno supstituirana sulfonil fenil, opcionalno supstituirana fenil amid i opcionalno supstituirana amid karbonil fenil grupa i da je Y opcionalno supstituiran piridin.
10. Aminopiridin za upotrebu prema bilo kojem od patentnih zahtjeva od 1 do 9, naznačen time da je aminopiridin odabran iz grupe koja slijedi: 3-(6-metoksipiridin-3-il)-5-(4-metilsulfonilfenil)piridin-2-amin; 5-(4-metilsulfonilfenil)-3-[3-(trifluorometil)fenil]piridin-2-amin; 3-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]fenol; 4-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]-2-metoksifenol; 4-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]fenol; 4-[2-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-2-metoksifenol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]-2,6-dimetilfenol; [4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]fenil]metanol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]fenol; (N,N-dimetil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N,N-dimetil benzamid; 5-(2-metoksipiridin-5-il)-3-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(pirimidin-5-il)piridin-2-amin; (morfolino){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 3,5-di(2-metoksipiridin-5-il)piridin-2-amin; (N-metil piperazin){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 3,5-di-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-[3-(metilsulfonil)fenil]piridin-2-amin; (N-metil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-metilbenzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzamid; 4-[6-amino-5-(2-metoksipiridin-5-il)piridin-3-il]benzojeva kiselina; N{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}metil sulfonamid; 4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-N-(3-hidroksipropil)-benzamid; 5-(benzo[c][[1,2,5]oksadiazol-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; N-ciklopropil-{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 5-(H-imidazo[1,2-a]piridin-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-3-il)-5-(1-metil-1H-indazol-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-ciklopropilbenzamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-(2-morfolino etil) benzamid; 3-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzamid; 3-(2-metoksipiridin-5-il)-5-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(6-morfolinopiridin-3-il)piridin-2-amin; 5-[4-(1H-pirazol-1-il)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(kinolin-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-[2-(pirolidin-1-il)etil]benzamid; 5-[2-(trifluoro metil)-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; {4-[2-amino-3-(4-karbamoilfenil)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metilpiridin-5-il)piridin-5-il]benzamid; [4-(2-amino-5-metilpiridin-3-il)-N-(2-hidroksietil) benzamido](morfolino) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzensulfonamid; 4-[2-amin-3-(4-benzamido)piridin-5-il]benzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(4-metilpiperazin-1-il) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-[4-(aminometil)tiazol-2-il]benzamid; {4-[2-amino-3-(4-(trifluorometil)fenil)piridin-5-il]fenil}(morfolino)metanon; 3-(2-metoksipiridin-3-il)-5-[4-(metilsulfonilfenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(piridin-3-il)piridin-2-amin; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}-N-metilbenzamid; 3-(H-imidazo[1,2-a]piridin-6-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksipirimidin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(kinoksalin-7-il)piridin-2-amin; 3-(furan-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-kloro-2-metoksipiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[3-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[4-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(pirolidin-1-il)piridin-5-il]piridin-2-amin; 3-[2-kloro-4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metoksipiridin-4-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(2-morfolino piridin-5-il)piridin-2-amin; 3-[2-(trifluorometil)piridin-4-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metilpiridin-5-il)-5-[4-(metil sulfonil)fenil]piridin-2-amin; 3-[2-(trifluoro-metil)piridin-5-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{4-[2-(pirolidin-1-il) etoksi]fenil}-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(4-morfolinofenil)piridin-2-amin; 3-[4-(1H-pirazol-1-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}pirimidin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 3-(6-metoksi-2-metilpiridin-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(izokinolin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(kinolin-6-il)piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-p-tolilpiridin-2-amin; {5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}metanol; 3-(2-metilbenzo[d]tiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; N{4-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]fenil}-2-(dimetilamino) acetamid; 3-(2-fluorpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(metilsulfonil)piridin-5-il]piridin-2-amin; N{5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}acetamid; 3-(benzo[c][1,2,5]oksadiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il]-N-(2-hidroksietil) benzamid; 3-[4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metilpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; i 5-[3-fluoro-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin.
11. Aminopiridin odabran iz grupe koju čine: 3-(6-metoksipiridin-3-il)-5-(4-metilsulfonilfenil)piridin-2-amin; 5-(4-metilsulfonilfenil)-3-[3-(trifluorometil)fenil]piridin-2-amin; 3-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]fenol; 4-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]-2-metoksifenol; 4-[2-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-2-metoksifenol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]-2,6-dimetilfenol; [4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]fenil]metanol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]fenol; (N,N-dimetil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N,N-dimetil benzamid; 5-(2-metoksipiridin-5-il)-3-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(pirimidin-5-il)piridin-2-amin; (morfolino){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; (N-metil piperazin){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 3,5-di-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-[3-(metil sulfonil)fenil]piridin-2-amin; (N-metil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-metilbenzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzamid; 4-[6-amino-5-(2-metoksipiridin-5-il)piridin-3-il]benzojeva kiselina; N{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}metil sulfonamid; 4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-N-(3-hidroksipropil)-benzamid; 5-(benzo[c][1,2,5]oksadiazol-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; N-ciklopropil-{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 5-(H-imidazo[1,2-a]piridin-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-3-il)-5-(1-metil-1H-indazol-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N(2-morfolino etil) benzamid; 3-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzamid; 3-(2-metoksipiridin-5-il)-5-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(6-morfolinopiridin-3-il)piridin-2-amin; 5-[4-(1H-pirazol-1-il)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(kinolin-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-[2-(pirolidin-1-il) etil]benzamid; 5-[2-(trifluoro metil)-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; {4-[2-amino-3-(4-karbamoil fenil)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metilpiridin-5-il)piridin-5-il]benzamid; [4-(2-amino-5-metilpiridin-3-il)-N-(2-hidroksietil)benzamido](morfolino) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5 il]benzen sulfonamid; 4-[2-amino-3-(4-benzamido)piridin-5-il]benzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(4-metilpiperazin-1-il) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N[4-(aminometil) tiazol-2-il]benzamid; {4-[2-amino-3-(4-(trifluorometil)fenil)piridin-5-il]fenil}(morfolino)metanon; 3-(2-metoksipiridin-3-il)-5-[4-(metil sulfonil fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(piridin-3-il)piridin-2-amin; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}-N-metilbenzamid; 3-(H-imidazo[1,2-a]piridin-6-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksi pirimidin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(kinoksalin-7-il)piridin-2-amin; 3-(furan-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-kloro-2-metoksipiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[3-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[4-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(pirolidin-1-il)piridin-5-il]piridin-2-amin; 3-[2-kloro-4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metoksipiridin-4-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(2-morfolino piridin-5-il)piridin-2-amin; 3-[2-(trifluorometil)piridin-4-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metilpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-[2-(trifluoro-metil)piridin-5-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{4-[2-(pirolidin-1-il) etoksi]fenil}-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(4-morfolinofenil)piridin-2-amin; 3-[4-(1H-pirazol-1-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}pirimidin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 3-(6-metoksi-2-metilpiridin-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(izokinolin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(kinolin-6-il)piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-p-tolilpiridin-2-amin; {5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}metanol; 3-(2-metilbenzo[d]tiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; N-{4-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]fenil}-2-(dimetilamino)acetamid; 3-(2-fluorpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(metilsulfonil)piridin-5-il]piridin-2-amin; N-{5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}acetamid; 3-(benzo[c][1,2,5]oksadiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il]-N-(2-hidroksietil) benzamid; 3-[4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metilpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; i 5-[3-fluoro-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin.
12. Aminopiridin opisan u patentnom zahtjevu 10 za upotrebu u vidu medikamenta, odabran iz grupe koju čine: 3-(6-metoksipiridin-3-il)-5-(4-metilsulfonilfenil)piridin-2-amin; 5-(4-metilsulfonilfenil)-3-[3-(trifluorometil)fenil]piridin-2-amin; 3-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]fenol; 4-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]-2-metoksifenol; 4-[2-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-2-metoksifenol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]-2,6-dimetilfenol; [4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]fenil]metanol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]fenol; (N,N-dimetil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N,N-dimetil benzamid; 5-(2-metoksipiridin-5-il)-3-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(pirimidin-5-il)piridin-2-amin; (morfolino){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 3,5-di(2-metoksipiridin-5-il)piridin-2-amin; (N-metil piperazin){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 3,5-di-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-[3-(metil sulfonil)fenil]piridin-2-amin; (N-metil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-metilbenzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzamid; 4-[6-amino-5-(2-metoksipiridin-5-il)piridin-3-il]benzojeva kiselina; N-{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}metil sulfonamid; 4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-N-(3-hidroksipropil)-benzamid; 5-(benzo[c][1,2,5]oksadiazol-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; N-ciklopropil-{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 5-(H-imidazo[1,2-a]piridin-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-3-il)-5-(1-metil-1H-indazol-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-(2-morfolinoetil)benzamid; 3-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-benzamid; 3-(2-metoksipiridin-5-il)-5-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(6-morfolinopiridin-3-il)piridin-2-amin; 5-[4-(1H-pirazol-1-il)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(kinolin-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N[2-(pirolidin-1-il)etil]benzamid; 5-[2-(trifluoro metil)-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; {4-[2-amino-3-(4-karbamoilfenil)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metilpiridin-5-il)piridin-5-il]benzamid; [4-(2-amino-5-metilpiridin-3-il)-N-(2-hidroksietil)benzamido](morfolino) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen sulfonamid; 4-[2-amino-3-(4-benzamido)piridin-5-il]benzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(4-metilpiperazin-1-il) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N[4-(aminometil)tiazol-2-il]benzamid; {4-[2-amino-3-(4-(trifluorometil)fenil)piridin-5-il]fenil}(morfolino)metanon; 3-(2-metoksipiridin-3-il)-5-[4-(metil sulfonil fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(piridin-3-il)piridin-2-amin; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}-N-metilbenzamid; 3-(H-imidazo[1,2-a]piridin-6-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksi pirimidin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(kinoksalin-7-il)piridin-2-amin; 3-(furan-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-kloro-2-metoksipiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[3-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[4-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(pirolidin-1-il)piridin-5-il]piridin-2-amin; 3-[2-kloro-4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metoksipiridin-4-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(2-morfolinopiridin-5-il)piridin-2-amin; 3-[2-(trifluorometil)piridin-4-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metilpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-[2-(trifluoro-metil)piridin-5-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{4-[2-(pirolidin-1-il)etoksi]fenil}-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(4-morfolinofenil)piridin-2-amin; 3-[4-(1H-pirazol-1-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}pirimidin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 3-(6-metoksi-2-metilpiridin-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(izokinolin-5-il)-5-[4-(metil sulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(kinolin-6-il)piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-p-tolilpiridin-2-amin; {5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}metanol; 3-(2-metilbenzo[d]tiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; N-{4-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]fenil}-2-(dimetilamino)acetamid; 3-(2-fluorpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(metilsulfonil)piridin-5-il]piridin-2-amin; N-{5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}acetamid; 3-(benzo[c][1,2,5]oksadiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il]-N-(2-hidroksietil) benzamid; 3-[4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metilpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; i 5-[3-fluoro-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin.
13. Farmaceutska formulacija koja sadrži najmanje jedan od derivata odabran iz grupe koju čine: 3-(6-metoksipiridin-3-il)-5-(4-metilsulfonilfenil)piridin-2-amin; 5-(4-metilsulfonilfenil)-3-[3-(trifluorometil)fenil]piridin-2-amin; 3-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il]fenol; 4-[2-amino-5-(4-metilsulfonilfenil)piridin-3-il)]-2-metoksifenol; 4-[2-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-2-metoksifenol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]-2,6-dimetilfenol; [4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]fenil]metanol; 4-[6-amino-5-[4-(4-metilpiperazin-1-il)fenil]piridin-3-il]fenol; (N,N-dimetil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N,N-dimetil benzamid; 5-(2-metoksipiridin-5-il)-3-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metil sulfonil)fenil]-3-(pirimidin-5-il)piridin-2-amin; (morfolino){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 3,5-di(2-metoksipiridin-5-il)piridin-2-amin; (N-metil piperazin){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 3,5-di-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-[3-(metil sulfonil)fenil]piridin-2-amin; (N-metil){4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-metilbenzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzamid; 4-[6-amino-5-(2-metoksipiridin-5-il)piridin-3-il]benzojeva kiselina; N-{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}metil sulfonamid; 4-[6-amino-5-(6-metoksipiridin-3-il)piridin-3-il]-N-(3-hidroksipropil) benzamid; 5-(benzo[c][1,2,5]oksadiazol-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; N-ciklopropil-{4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen}sulfonamid; 5-(H-imidazo[1,2-a]piridin-6-il)-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-3-il)-5-(1-metil-1H-indazol-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N-(2-morfolinoetil)benzamid; 3-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzamid; 3-(2-metoksipiridin-5-il)-5-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(6-morfolinopiridin-3-il)piridin-2-amin; 5-[4-(1H-pirazol-1-il)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; 3-(2-metoksipiridin-5-il)-5-(kinolin-6-il)piridin-2-amin; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N[2-(pirolidin-1-il)etil]benzamid; 5-[2-(trifluorometil)-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin; {4-[2-amino-3-(4-karbamoilfenil)piridin-5-il]fenil}(morfolino)metanon; 4-[2-amino-3-(2-metilpiridin-5-il)piridin-5-il]benzamid; [4-(2-amino-5-metilpiridin-3-il)-N-(2-hidroksietil) benzamido](morfolino) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]benzen sulfonamid 4-[2-amin-3-(4-benzamido)piridin-5-il]benzamid; {4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]fenil}(4-metilpiperazin-1-il) metanon; 4-[2-amino-3-(2-metoksipiridin-5-il)piridin-5-il]-N[4-(aminometil)tiazol-2-il]benzamid; {4-[2-amino-3-(4-(trifluorometil)fenil)piridin-5-il]fenil}(morfolino)metanon; 3-(2-metoksipiridin-3-il)-5-[4-(metilsulfonilfenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(piridin-3-il)piridin-2-amin; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzonitril; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 4-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}-N-metilbenzamid; 3-(H-imidazo[1,2-a]piridin-6-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metoksipirimidin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(kinoksalin-7-il)piridin-2-amin; 3-(furan-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-[4-(5-metil-1,3,4-oksadiazol-2-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-kloro-2-metoksipiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[3-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[4-(trifluorometoksi)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(pirolidin-1-il)piridin-5-il]piridin-2-amin; 3-[2-kloro-4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metoksipiridin-4-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(2-morfolino piridin-5-il)piridin-2-amin; 3-[2-(trifluorometil)piridin-4-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(2-metilpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-[2-(trifluoro-metil)piridin-5-il]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{4-[2-(pirolidin-1-il)etoksi]fenil}-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(4-morfolinofenil)piridin-2-amin; 3-[4-(1H-pirazol-1-il)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}pirimidin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il}benzamid; 3-(6-metoksi-2-metilpiridin-3-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(izokinolin-5-il)-5-[4-(metil sulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-(kinolin-6-il)piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-p-tolilpiridin-2-amin; {5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}metanol; 3-(2-metilbenzo[d]tiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; N-{4-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]fenil}-2-(dimetilamino) acetamid; 3-(2-fluorpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 5-[4-(metilsulfonil)fenil]-3-[2-(metilsulfonil)piridin-5-il]piridin-2-amin; N-{5-[2-amino-5-(4-(metilsulfonil)fenil)piridin-3-il]piridin-2-il}acetamid; 3-(benzo[c][1,2,5]oksadiazol-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-{2-amino-5-[4-(metilsulfonil)fenil]piridin-3-il]-N-(2-hidroksietil) benzamid; 3-[4-(trifluorometil)fenil]-5-[4-(metilsulfonil)fenil]piridin-2-amin; 3-(3-metilpiridin-5-il)-5-[4-(metilsulfonil)fenil]piridin-2-amin; i 5-[3-fluoro-4-(metilsulfonil)fenil]-3-(2-metoksipiridin-5-il)piridin-2-amin i njihovi farmaceutski prihvatljivi nosači, razrjeđivači ili ekscipijensi.
14. Farmaceutska formulacija koji sadrži aminopiridin prema formuli (I) i antimalarijski agens, naznačen time da su X i Y definirani u bilo kojem od prethodnih patentnih zahtjeva.
15. Aminopiridin za upotrebu prema bilo kom od patentnih zahtjeva od 1 do 10, naznačen time da se aminopiridin ili njegova farmaceutska formulacija primjenjuju u kombinaciji sa ko-agensom koji je od koristi u liječenju malarije.
16. Aminopiridin za upotrebu prema patentnom zahtjevu 15, naznačen time da je ko-agens odabran iz grupe koju čine artemeter, klorokin, meflokin, kinin, atovakvon/progvanil, doksiciklin, artesunat, hidroksiklorokin, halofantrin, pirimetamin-sulfadoksin, primakin i piperakin.
HRP20151143TT 2010-01-18 2015-10-28 Novi antimalarijski agensi HRP20151143T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29582110P 2010-01-18 2010-01-18
PCT/IB2011/050192 WO2011086531A2 (en) 2010-01-18 2011-01-17 New anti-malarial agents
EP11704673.0A EP2526090B1 (en) 2010-01-18 2011-01-17 New anti-malarial agents

Publications (1)

Publication Number Publication Date
HRP20151143T1 true HRP20151143T1 (hr) 2015-12-04

Family

ID=43759659

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20151143TT HRP20151143T1 (hr) 2010-01-18 2015-10-28 Novi antimalarijski agensi

Country Status (18)

Country Link
US (1) US9024033B2 (hr)
EP (1) EP2526090B1 (hr)
JP (1) JP5735986B2 (hr)
CN (1) CN102812006B (hr)
BR (1) BR112012017713A2 (hr)
CA (1) CA2787121C (hr)
DK (1) DK2526090T3 (hr)
ES (1) ES2551875T3 (hr)
HK (1) HK1175472A1 (hr)
HR (1) HRP20151143T1 (hr)
HU (1) HUE027946T2 (hr)
ME (1) ME02315B (hr)
PL (1) PL2526090T3 (hr)
PT (1) PT2526090E (hr)
RS (1) RS54339B1 (hr)
SI (1) SI2526090T1 (hr)
SM (1) SMT201500291B (hr)
WO (1) WO2011086531A2 (hr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5753093B2 (ja) 2008-12-19 2015-07-22 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ａｔｒキナーゼのインヒビターとして有用なピラジン誘導体
CN102947272A (zh) * 2010-05-12 2013-02-27 沃泰克斯药物股份有限公司 用作atr激酶抑制剂的2-氨基吡啶衍生物
CN103228651A (zh) 2010-05-12 2013-07-31 沃泰克斯药物股份有限公司 可用作atr激酶抑制剂的化合物
WO2011143425A2 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
ES2639426T3 (es) * 2011-03-04 2017-10-26 Lexicon Pharmaceuticals, Inc. Inhibidores de cinasa MST1 y métodos para su uso
KR102184246B1 (ko) 2011-09-30 2020-12-01 버텍스 파마슈티칼스 인코포레이티드 Ａｔｒ 키나제의 억제제로서 유용한 화합물의 제조 방법
IN2014CN02501A (hr) 2011-09-30 2015-06-26 Vertex Pharma
PT2814820T (pt) 2012-02-17 2016-10-25 Medicines For Malaria Venture Mmv Novos agentes antimaláricos
AU2013243291B2 (en) 2012-04-05 2018-02-01 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase and combination therapies thereof
DK2904406T3 (en) 2012-10-04 2018-06-18 Vertex Pharma METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE
PT2970185T (pt) 2013-03-15 2023-10-06 Corteva Agriscience Llc 4-amino-6-(heterocíclico)picolinatos e 6-amino-2-(heterocíclico)pirimidino-4-carboxilatos e seu uso como herbicidas
WO2014151009A1 (en) * 2013-03-15 2014-09-25 Dow Agrosciences Llc 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic) pyrimidine-4-carboxylates and their use as herbicides
BR112016024484A2 (pt) * 2014-04-24 2017-08-15 Novartis Ag derivados de aminopiridina como inibidores de fosfatidilinositol 3-quinase
MX2016013983A (es) 2014-04-24 2017-04-06 Novartis Ag Derivados de pirazina como inhibidores de fosfatidil-inositol-3-ci nasa.
BR112016024533A8 (pt) 2014-04-24 2021-03-30 Novartis Ag derivados de amino pirazina como inibidores de fosfatidilinositol 3-cinase ou sal, seu uso, e composição e combinação farmacêuticas
WO2016150800A1 (en) * 2015-03-20 2016-09-29 F. Hoffmann-La Roche Ag Usp7 inhibitor compounds and methods of use
EP3118198A1 (en) * 2015-07-13 2017-01-18 MMV Medicines for Malaria Venture Anti-malarial agents
AU2016331955B2 (en) 2015-09-30 2022-07-21 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
WO2017067881A1 (en) * 2015-10-19 2017-04-27 Glaxosmithkline Intellectual Property Development Limited Pyrazine compounds for use in the treatment of parasitic protozoal infections
GB201603104D0 (en) * 2016-02-23 2016-04-06 Ucb Biopharma Sprl Therapeutic agents
EP3254679A1 (de) 2016-06-09 2017-12-13 Christian-Albrechts-Universität zu Kiel Wirkstoffe gegen protozoen und bakterien
MX2020006613A (es) * 2017-12-22 2020-11-13 Ravenna Pharmaceuticals Inc Derivados de aril-bipiridina amina como inhibidores de fosfatidilinositol fosfato cinasa.
PT3762368T (pt) 2018-03-08 2022-05-06 Incyte Corp Compostos de aminopirazina diol como inibidores de pi3k-y
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
EP3842100A1 (en) * 2019-12-24 2021-06-30 The Board Of Regents Of The University Of Texas System Anti-malarial agents
WO2024033281A1 (en) 2022-08-09 2024-02-15 Merck Patent Gmbh Furo pyrimidine derivates
WO2024033280A1 (en) 2022-08-09 2024-02-15 Merck Patent Gmbh Furopyridin and furopyrimidin, inhibitors of pi4k, for use in the treatment of parasite infection and malaria

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100574350B1 (ko) 2004-08-31 2006-04-27 한국화학연구원 2-아미노피리딘 유도체의 제조방법
WO2007032016A1 (en) 2005-09-12 2007-03-22 Council Of Scientific And Industrial Research An antimalarial baylis-hillman adducts and a process for the preparation thereof
EP1900727A1 (en) * 2006-08-30 2008-03-19 Cellzome Ag Aminopyridine derivatives as kinase inhibitors
CN101555248B (zh) 2009-05-22 2011-06-22 北京欧凯纳斯科技有限公司 一种多取代1,5-萘啶化合物的制备方法

Also Published As

Publication number Publication date
CA2787121C (en) 2018-07-17
DK2526090T3 (en) 2015-10-19
SI2526090T1 (sl) 2015-11-30
RS54339B1 (en) 2016-02-29
US20120295905A1 (en) 2012-11-22
PL2526090T3 (pl) 2016-04-29
HUE027946T2 (en) 2016-11-28
JP2013517264A (ja) 2013-05-16
WO2011086531A3 (en) 2011-09-29
CA2787121A1 (en) 2011-07-21
US9024033B2 (en) 2015-05-05
HK1175472A1 (zh) 2013-07-05
JP5735986B2 (ja) 2015-06-17
PT2526090E (pt) 2015-11-30
EP2526090B1 (en) 2015-08-19
BR112012017713A2 (pt) 2020-06-23
CN102812006B (zh) 2016-01-20
ES2551875T3 (es) 2015-11-24
CN102812006A (zh) 2012-12-05
SMT201500291B (it) 2016-01-08
WO2011086531A2 (en) 2011-07-21
EP2526090A2 (en) 2012-11-28
ME02315B (me) 2016-06-20

Similar Documents

Publication Publication Date Title
HRP20151143T1 (hr) Novi antimalarijski agensi
JP2013517264A5 (hr)
US8420827B2 (en) Thiazole derivatives
HRP20210459T1 (hr) Supstituirani derivati oksopiridina
JP2008545686A5 (hr)
RU2013102401A (ru) Анеллированные производные пиридина
JP2010513444A5 (hr)
RU2006136881A (ru) Фармацевтическая композиция, содержащая производное бензодиазепина и ингибитор белка слияния rsv
JP2016522246A5 (hr)
RU2007132262A (ru) Соединения и композиции в качестве ингибиторов протеинкиназ
HRP20150347T1 (hr) Analozi 2-aminopiridina kao aktivatori glukokinaze
RU2015143430A (ru) Новые соединения и фармацевтические композиции, их содержащие, для лечения воспалительных расстройств
JP2008526721A5 (hr)
RU2013145299A (ru) Тиазолопиримидины
JP2007519735A5 (hr)
AR082458A1 (es) Combinacion que comprende un farmaco antipsicotico y un agonista de taar1
JP2004534755A5 (hr)
RU2012132527A (ru) ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ИХ ПОЛУЧЕНИЯ, КОМПОЗИЦИЯ, ИХ СОДЕРЖАЩАЯ, И СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С КИНАЗОЙ mTOR ИЛИ КИНАЗОЙ PI3K
RU2008112221A (ru) Соединения ряда изоиндолимидов, их композиции и способы применения
HRP20110520T1 (hr) Acilaminopirazoli kao inhibitori fgfr
JP2012510989A5 (hr)
HRP20120748T1 (hr) Heterocikliäśki spoj i farmaceutski sastavi koji ga sadrže
JP2008525500A5 (hr)
JP2013517273A5 (hr)
RU2017121044A (ru) Производные амидотиадиазола в качестве ингибиторов надфн-оксидазы