|
US6403597B1
(en)
*
|
1997-10-28 |
2002-06-11 |
Vivus, Inc. |
Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
|
|
US20040014761A1
(en)
*
|
1997-10-28 |
2004-01-22 |
Place Virgil A. |
Treatment of female sexual dysfunction with phosphodiesterase inhibitors
|
|
DK1049695T3
(da)
*
|
1997-11-12 |
2002-05-13 |
Bayer Ag |
2-Phenyl-substituerede imidazotriazinoner som phosphodiesterase-inhibitorer
|
|
DE19827640A1
(de)
*
|
1998-06-20 |
1999-12-23 |
Bayer Ag |
7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone
|
|
US7235625B2
(en)
|
1999-06-29 |
2007-06-26 |
Palatin Technologies, Inc. |
Multiple agent therapy for sexual dysfunction
|
|
DE19944161A1
(de)
*
|
1999-09-15 |
2001-03-22 |
Bayer Ag |
Neue Kombination zur Behandlung von sexueller Dysfunktion
|
|
CA2323008C
(en)
*
|
1999-10-11 |
2005-07-12 |
Pfizer Inc. |
Pharmaceutically active compounds
|
|
IL139454A0
(en)
*
|
1999-11-08 |
2001-11-25 |
Pfizer |
Compounds for the treatment of female sexual dysfunction
|
|
US20050020547A1
(en)
*
|
1999-11-08 |
2005-01-27 |
Pfizer Inc. |
Compounds for the treatment of female sexual dysfunction
|
|
DE50008549D1
(de)
*
|
1999-12-24 |
2004-12-09 |
Bayer Healthcare Ag |
Triazolotriazinone und ihre verwendung
|
|
JP2003519153A
(ja)
|
1999-12-24 |
2003-06-17 |
バイエル アクチェンゲゼルシャフト |
イソオキサゾロピリミジノン類及びその使用
|
|
WO2001047928A2
(de)
*
|
1999-12-24 |
2001-07-05 |
Bayer Aktiengesellschaft |
Imidazo 1,3,5 triazinone und ihre verwendung
|
|
DE10010067A1
(de)
*
|
2000-03-02 |
2001-09-06 |
Bayer Ag |
Neue Imidazotriazinone und ihre Verwendung
|
|
JP2004500425A
(ja)
|
2000-04-19 |
2004-01-08 |
リリー アイコス リミテッド ライアビリティ カンパニー |
パーキンソン病の処置に対する環状gmp特異的ホスホジエステラーゼインヒビターの使用
|
|
US6821978B2
(en)
*
|
2000-09-19 |
2004-11-23 |
Schering Corporation |
Xanthine phosphodiesterase V inhibitors
|
|
CZ20031194A3
(cs)
*
|
2000-09-29 |
2003-08-13 |
Glaxo Group Limited |
Deriváty močoviny
|
|
US6548508B2
(en)
|
2000-10-20 |
2003-04-15 |
Pfizer, Inc. |
Use of PDE V inhibitors for improved fecundity in mammals
|
|
US20020091129A1
(en)
*
|
2000-11-20 |
2002-07-11 |
Mitradev Boolell |
Treatment of premature ejaculation
|
|
DE10063106A1
(de)
*
|
2000-12-18 |
2002-06-20 |
Bayer Ag |
Verfahren zur Herstellung von 2-(2-Ethoxyphenyl)-substituierten Imidazotriazinonen
|
|
DE10063108A1
(de)
*
|
2000-12-18 |
2002-06-20 |
Bayer Ag |
Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
|
|
DE10064105A1
(de)
|
2000-12-21 |
2002-06-27 |
Bayer Ag |
Neue Substituierte Imidazotriazinone
|
|
US6683080B2
(en)
|
2001-02-02 |
2004-01-27 |
Pfizer Inc. |
Treatment of diabetes mellitus
|
|
DE10107639A1
(de)
*
|
2001-02-15 |
2002-08-22 |
Bayer Ag |
2-Alkoxyphenyl-substituierte Imidazotriazinone
|
|
DE10108752A1
(de)
|
2001-02-23 |
2002-09-05 |
Bayer Ag |
Neue Substituierte Imidazotriazinone
|
|
GB0107751D0
(en)
*
|
2001-03-28 |
2001-05-16 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
DE10118306A1
(de)
*
|
2001-04-12 |
2002-10-17 |
Bayer Ag |
Imidazotriazinonhaltige Zusammensetzungen zur nasalen Applikation
|
|
JP4540295B2
(ja)
*
|
2001-05-09 |
2010-09-08 |
バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト |
2−フェニル置換イミダゾトリアジノンの新しい用途
|
|
US20070122353A1
(en)
|
2001-05-24 |
2007-05-31 |
Hale Ron L |
Drug condensation aerosols and kits
|
|
US7766013B2
(en)
|
2001-06-05 |
2010-08-03 |
Alexza Pharmaceuticals, Inc. |
Aerosol generating method and device
|
|
US7458374B2
(en)
|
2002-05-13 |
2008-12-02 |
Alexza Pharmaceuticals, Inc. |
Method and apparatus for vaporizing a compound
|
|
US7585493B2
(en)
|
2001-05-24 |
2009-09-08 |
Alexza Pharmaceuticals, Inc. |
Thin-film drug delivery article and method of use
|
|
US7090830B2
(en)
|
2001-05-24 |
2006-08-15 |
Alexza Pharmaceuticals, Inc. |
Drug condensation aerosols and kits
|
|
GB0113344D0
(en)
|
2001-06-01 |
2001-07-25 |
Bayer Ag |
Novel heterocycles 3
|
|
US7087605B2
(en)
|
2001-06-01 |
2006-08-08 |
Bayer Aktiengesellschaft |
5-Ethyl-imidazotriazinones
|
|
DE10130167A1
(de)
*
|
2001-06-22 |
2003-01-02 |
Bayer Ag |
Imidazotriazine
|
|
DE10135815A1
(de)
*
|
2001-07-23 |
2003-02-06 |
Bayer Ag |
Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
|
|
MXPA04001891A
(es)
|
2001-08-28 |
2004-06-15 |
Schering Corp |
Inhibidores policiclicos de guanina fosfodiesterasa v.
|
|
CN1585771A
(zh)
*
|
2001-11-09 |
2005-02-23 |
先灵公司 |
多环鸟嘌呤衍生物磷酸二酯酶v抑制剂
|
|
GB0129274D0
(en)
*
|
2001-12-06 |
2002-01-23 |
Pfizer Ltd |
Novel kit
|
|
BRPI0207215B8
(pt)
*
|
2001-12-13 |
2022-11-01 |
Daiichi Suntory Biomedical Res Limited |
Derivados de pirazolopirimidinona tendo ação de inibição de pde7
|
|
GB0130219D0
(en)
*
|
2001-12-18 |
2002-02-06 |
Pfizer Ltd |
Compounds for the treatment of sexual dysfunction
|
|
GB0209988D0
(en)
*
|
2002-05-01 |
2002-06-12 |
Bayer Ag |
Novel Heterocycles
|
|
DE10220570A1
(de)
|
2002-05-08 |
2003-11-20 |
Bayer Ag |
Carbamat-substituierte Pyrazolopyridine
|
|
AU2003265239A1
(en)
|
2002-05-22 |
2003-12-19 |
Virginia Commonwealth University |
Protective effects of pde-5 inhibitors
|
|
PL374198A1
(en)
*
|
2002-05-23 |
2005-10-03 |
Pfizer Inc. |
Novel combination
|
|
SI1509525T1
(sl)
|
2002-05-31 |
2006-12-31 |
Schering Corp |
Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
|
|
GB0214784D0
(en)
*
|
2002-06-26 |
2002-08-07 |
Pfizer Ltd |
Novel combination
|
|
DE10229778A1
(de)
*
|
2002-07-03 |
2004-01-29 |
Bayer Ag |
Neue Verwendung von Imidazotriazinonen
|
|
DE10230605A1
(de)
|
2002-07-08 |
2004-01-29 |
Bayer Ag |
Substituierte Imidazotriazine
|
|
DE10232113A1
(de)
*
|
2002-07-16 |
2004-01-29 |
Bayer Ag |
Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
|
|
GB0219961D0
(en)
|
2002-08-28 |
2002-10-02 |
Pfizer Ltd |
Oxytocin inhibitors
|
|
US7323462B2
(en)
|
2002-12-10 |
2008-01-29 |
Pfizer Inc. |
Morpholine dopamine agonists
|
|
NZ567457A
(en)
|
2002-12-13 |
2009-08-28 |
Warner Lambert Co |
Alpha-2-delta ligand to treat lower urinary tract symptoms
|
|
JP2006522127A
(ja)
*
|
2003-04-01 |
2006-09-28 |
スミスクライン ビーチャム コーポレーション |
イミダゾトリアジン化合物
|
|
EP1620437B1
(en)
|
2003-04-29 |
2009-06-17 |
Pfizer Limited |
5,7-diaminopyrazolo¬4,3-d pyrimidines useful in the traetment of hypertension
|
|
US20040220186A1
(en)
*
|
2003-04-30 |
2004-11-04 |
Pfizer Inc. |
PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
|
|
US20040234699A1
(en)
|
2003-05-21 |
2004-11-25 |
Alexza Molecular Delivery Corporation |
Methods of controlling uniformity of substrate temperature and self-contained heating unit and drug-supply unit employing same
|
|
CN1791429A
(zh)
|
2003-05-22 |
2006-06-21 |
奥坦纳医药公司 |
包含pde4抑制剂和pde5抑制剂的组合物
|
|
CN100374441C
(zh)
|
2003-06-06 |
2008-03-12 |
天津倍方科技发展有限公司 |
二氢吡咯[2,3-d]嘧啶-4-酮衍生物,其制备方法及其制药用途
|
|
JP2006219374A
(ja)
|
2003-06-13 |
2006-08-24 |
Daiichi Asubio Pharma Co Ltd |
Pde7阻害作用を有するイミダゾトリアジノン誘導体
|
|
US20050079548A1
(en)
*
|
2003-07-07 |
2005-04-14 |
Plexxikon, Inc. |
Ligand development using PDE4B crystal structures
|
|
US7291640B2
(en)
*
|
2003-09-22 |
2007-11-06 |
Pfizer Inc. |
Substituted triazole derivatives as oxytocin antagonists
|
|
PE20050985A1
(es)
*
|
2003-11-21 |
2005-11-26 |
Schering Corp |
Formulaciones de inhibidores de la fosfodiesterasa v
|
|
GB0327323D0
(en)
*
|
2003-11-24 |
2003-12-31 |
Pfizer Ltd |
Novel pharmaceuticals
|
|
US7572799B2
(en)
*
|
2003-11-24 |
2009-08-11 |
Pfizer Inc |
Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
|
|
US7449462B2
(en)
|
2004-01-22 |
2008-11-11 |
Pfizer, Inc. |
Triazole derivatives which inhibit vasopressin antagonistic activity
|
|
ATE417849T1
(de)
*
|
2004-04-07 |
2009-01-15 |
Pfizer |
Pyrazoloä4,3-düpyrimidine
|
|
DE102004023069A1
(de)
|
2004-05-11 |
2005-12-08 |
Bayer Healthcare Ag |
Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
|
|
US7540286B2
(en)
|
2004-06-03 |
2009-06-02 |
Alexza Pharmaceuticals, Inc. |
Multiple dose condensation aerosol devices and methods of forming condensation aerosols
|
|
JP2008501617A
(ja)
*
|
2004-06-11 |
2008-01-24 |
アスビオファーマ株式会社 |
Pde7阻害作用を有するイミダゾトリアジノン誘導体
|
|
CA2576961A1
(en)
|
2004-08-12 |
2006-03-02 |
Alexza Pharmaceuticals, Inc. |
Aerosol drug delivery device incorporating percussively activated heat packages
|
|
DE102005001989A1
(de)
*
|
2005-01-15 |
2006-07-20 |
Bayer Healthcare Ag |
Intravenöse Formulierungen von PDE-Inhibitoren
|
|
EA200701752A1
(ru)
*
|
2005-02-18 |
2008-04-28 |
Сурфейс Логикс Инк. |
Способ получения усовершенствованных фармакокинетических соединений, включающих функциональные остатки или группы, и фармацевтические композиции, содержащие эти соединения
|
|
UA90502C2
(ru)
*
|
2005-02-18 |
2010-05-11 |
Сьёрфейс Лоджикс, Инк. |
Имидазотриазиноновые соединения и фармацевтическая композиция, которая их содержит
|
|
DE102005009240A1
(de)
*
|
2005-03-01 |
2006-09-07 |
Bayer Healthcare Ag |
Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
|
|
DE102005009241A1
(de)
|
2005-03-01 |
2006-09-07 |
Bayer Healthcare Ag |
Arzneiformen mit kontrollierter Bioverfügbarkeit
|
|
DE102005016345A1
(de)
*
|
2005-04-09 |
2006-10-12 |
Bayer Healthcare Ag |
Neue Verwendung von 2-Phenyl-substituierten Imidazotriazinon-Derivaten
|
|
MX2007012711A
(es)
|
2005-04-19 |
2008-01-11 |
Nycomed Gmbh |
Roflumilast para el tratamiento de hipertension pulmonar.
|
|
AU2006245416B2
(en)
|
2005-05-12 |
2012-02-23 |
Pfizer Inc. |
Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide
|
|
WO2006127368A2
(en)
*
|
2005-05-20 |
2006-11-30 |
Lexicon Genetics Incorporated |
Methods for synthesizing imidazotriazinones
|
|
US20070010525A1
(en)
*
|
2005-06-27 |
2007-01-11 |
Meyer Jackson |
Method and compositions for modulating neuropeptide hormone secretion
|
|
CA2618103A1
(en)
*
|
2005-08-10 |
2007-02-15 |
Pfizer Limited |
Substituted triazole derivatives as oxytocin antagonists
|
|
EP1928437A2
(en)
|
2005-08-26 |
2008-06-11 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation
|
|
EP2258357A3
(en)
|
2005-08-26 |
2011-04-06 |
Braincells, Inc. |
Neurogenesis with acetylcholinesterase inhibitor
|
|
BRPI0616633A2
(pt)
|
2005-09-29 |
2011-06-28 |
Bayer Healthcare Ag |
inibidores de pde e combinações dos mesmos para o tratamento de transtornos urológicos
|
|
WO2007047282A1
(en)
*
|
2005-10-12 |
2007-04-26 |
Lilly Icos Llc |
Treatment of benign prostatic hypertrophy and lower urinary tract symptoms
|
|
WO2007047978A2
(en)
|
2005-10-21 |
2007-04-26 |
Braincells, Inc. |
Modulation of neurogenesis by pde inhibition
|
|
WO2007053596A1
(en)
|
2005-10-31 |
2007-05-10 |
Braincells, Inc. |
Gaba receptor mediated modulation of neurogenesis
|
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
|
PE20080109A1
(es)
*
|
2006-02-17 |
2008-04-01 |
Wyeth Corp |
N-sulfonilacion selectiva de alcoholes sustituidos con 2-aminotrifluoralquilo
|
|
CA2641013A1
(en)
*
|
2006-02-17 |
2007-08-30 |
Wyeth |
Methods for preparing sulfonamide substituted alcohols and intermediates thereof
|
|
US20100216734A1
(en)
|
2006-03-08 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
|
US7977478B2
(en)
*
|
2006-03-13 |
2011-07-12 |
Dr. Reddy's Laboratories Limited |
Polymorphic forms of vardenafil
|
|
EP2596785A1
(en)
*
|
2006-03-17 |
2013-05-29 |
Johns Hopkins University School of Medicine |
N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
|
|
WO2007124045A2
(en)
*
|
2006-04-20 |
2007-11-01 |
Ampla Pharmaceuticals, Inc. |
Piperidine and piperazine compounds for use in the treatment of obesity, eating disorders and sexual dysfunction by potentiation of mc4 receptor activity
|
|
JP2009536667A
(ja)
|
2006-05-09 |
2009-10-15 |
ブレインセルス,インコーポレイティド |
5ht受容体介在性の神経新生
|
|
EP2021000A2
(en)
|
2006-05-09 |
2009-02-11 |
Braincells, Inc. |
Neurogenesis by modulating angiotensin
|
|
AU2007264030B2
(en)
|
2006-06-27 |
2012-04-05 |
Sandoz Ag |
New method for salt preparation
|
|
EP2040698A4
(en)
*
|
2006-07-14 |
2011-08-10 |
Shionogi & Co |
OXIM CONNECTIONS AND ITS USE
|
|
CN101528042A
(zh)
*
|
2006-08-24 |
2009-09-09 |
表面线段公司 |
药代动力学改进的化合物
|
|
AR062501A1
(es)
|
2006-08-29 |
2008-11-12 |
Actelion Pharmaceuticals Ltd |
Composiciones terapeuticas
|
|
KR20090064418A
(ko)
|
2006-09-08 |
2009-06-18 |
브레인셀즈 인코퍼레이션 |
4-아실아미노피리딘 유도체 포함 조합물
|
|
DE102006043443A1
(de)
*
|
2006-09-15 |
2008-03-27 |
Bayer Healthcare Ag |
Neue aza-bicyclische Verbindungen und ihre Verwendung
|
|
US20100184806A1
(en)
|
2006-09-19 |
2010-07-22 |
Braincells, Inc. |
Modulation of neurogenesis by ppar agents
|
|
US8314119B2
(en)
*
|
2006-11-06 |
2012-11-20 |
Abbvie Inc. |
Azaadamantane derivatives and methods of use
|
|
PL2101777T3
(pl)
|
2006-12-12 |
2015-10-30 |
Gilead Sciences Inc |
Kompozycja do leczenia nadciśnienia płucnego
|
|
EP2114147B9
(en)
|
2007-02-12 |
2013-04-10 |
DMI Biosciences, Inc. |
Reducing side effects of tramadol
|
|
US20080194529A1
(en)
*
|
2007-02-12 |
2008-08-14 |
Auspex Pharmaceuticals, Inc. |
HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS
|
|
CN101657101B
(zh)
*
|
2007-02-12 |
2013-12-11 |
Dmi生物科学公司 |
并存早泄和勃起功能障碍的治疗
|
|
EP2121088B1
(en)
|
2007-03-09 |
2016-07-13 |
Alexza Pharmaceuticals, Inc. |
Heating unit for use in a drug delivery device
|
|
DE102007027067A1
(de)
*
|
2007-06-12 |
2008-12-18 |
Ratiopharm Gmbh |
Verfahren zur Herstellung eines Arzneimittels enthaltend Vardenafil Hydrochlorid Trihydrat
|
|
CA2689638A1
(en)
*
|
2007-06-13 |
2008-12-18 |
Bayer Schering Pharma Aktiengesellschaft |
Pde inhibitors for the treatment of hearing impairment
|
|
WO2009030095A1
(fr)
*
|
2007-09-06 |
2009-03-12 |
Topharman Shanghai Co., Ltd. |
Procédé de préparation de vardénafil et de ses intermédiaires
|
|
ES2388371T3
(es)
|
2007-12-28 |
2012-10-15 |
Topharman Shanghai Co., Ltd. |
N-{1-[3-(2-etoxi-5-(4-etilpiperazinil)bencenosulfonil)-4,5-dihidro-5-oxo-1,2,4-triazin-6-il]etil}-butiramida, método de preparación y uso
|
|
WO2009091777A1
(en)
*
|
2008-01-15 |
2009-07-23 |
Forest Laboratories Holdings Limited |
Nebivolol in the treatment of sexual dysfunction
|
|
DE102008063992A1
(de)
|
2008-12-19 |
2010-09-02 |
Lerner, Zinoviy, Dipl.-Ing. |
Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung
|
|
EP2379076B1
(en)
|
2008-12-23 |
2014-11-12 |
The Trustees of Columbia University in the City of New York |
Phosphodiesterase inhibitors and uses thereof
|
|
US20100216805A1
(en)
|
2009-02-25 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis using d-cycloserine combinations
|
|
GB0903493D0
(en)
|
2009-02-27 |
2009-04-08 |
Vantia Ltd |
New compounds
|
|
DE102009020888A1
(de)
|
2009-05-12 |
2010-11-18 |
Ratiopharm Gmbh |
Schmelztablette, enthaltend ein Vardenafil-Salz
|
|
CA2770471A1
(en)
|
2009-08-07 |
2011-02-10 |
Ranbaxy Laboratories Limited |
Processes for the preparation of vardenafil
|
|
KR101766931B1
(ko)
|
2009-11-27 |
2017-08-09 |
아드베리오 파마 게엠베하 |
제약상 물질로서 사용하기 위한 메틸-(4,6-디아미노-2-(1-(2-플루오로벤질)-1h-피라졸로(3,4-b)피리디노-3-일)피리미디노-5-일)메틸카르바메이트의 제조 방법 및 그의 정제
|
|
UY33041A
(es)
|
2009-11-27 |
2011-06-30 |
Bayer Schering Pharma Aktienegesellschaft |
Procedimiento para la preparaciòn de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo y su purificaciòn para el uso como principio activo farmacèutico
|
|
WO2011075801A1
(pt)
|
2009-12-21 |
2011-06-30 |
Acef S.A. |
Cubebina, lignana dibenzilbutirolactólica, seus derivados semi-sintéticos e sintéticos, bem como outras lignanas e neolignanas como agente vasodilatador na terapia da disfunção erétil
|
|
PL390079A1
(pl)
*
|
2009-12-30 |
2011-07-04 |
Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna |
Sposób otrzymywania wardenafilu i jego izolacji jako soli z kwasem cytrynowym oraz krystaliczna postać tej soli
|
|
CN102970965A
(zh)
|
2010-04-05 |
2013-03-13 |
Sk化学公司 |
含有pde5抑制剂的减少皮肤皱纹的合成物
|
|
DE102010021637A1
(de)
|
2010-05-26 |
2011-12-01 |
Bayer Schering Pharma Aktiengesellschaft |
Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
|
|
CN102382129B
(zh)
*
|
2010-08-19 |
2014-02-26 |
山东轩竹医药科技有限公司 |
螺环取代的磷酸二酯酶抑制剂
|
|
CN102372730B
(zh)
*
|
2010-08-19 |
2014-03-26 |
山东轩竹医药科技有限公司 |
桥环取代的磷酸二酯酶抑制剂
|
|
TWI541244B
(zh)
|
2010-09-20 |
2016-07-11 |
福倫製藥股份有限公司 |
咪唑三酮化合物
|
|
CA2809675A1
(en)
|
2010-09-23 |
2012-03-29 |
Shuang Chen |
Monohydrate of an azaadamantane derivative
|
|
ES2627944T3
(es)
|
2010-10-15 |
2017-08-01 |
Gilead Sciences, Inc. |
Composiciones y métodos de tratamiento de hipertensión pulmonar
|
|
TWI462739B
(zh)
|
2010-11-02 |
2014-12-01 |
Univ Kaohsiung Medical |
Sildenafil-同族物四級銨哌嗪鹽類之製備及醫療用途
|
|
CN102134242B
(zh)
*
|
2011-01-21 |
2013-08-28 |
浙江大德药业集团有限公司 |
一种用于治疗阳痿的快速长效的化合物
|
|
JP2015531401A
(ja)
|
2011-10-10 |
2015-11-02 |
ハー・ルンドベック・アクチエゼルスカベット |
イミダゾピラジノン骨格を有するpde9i
|
|
AT512084A1
(de)
|
2011-10-20 |
2013-05-15 |
Univ Wien Tech |
Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren
|
|
US9402877B2
(en)
|
2011-11-04 |
2016-08-02 |
Xion Pharmaceuticals Corporation |
Methods and compositions for oral administration of melanocortin receptor agonist compounds
|
|
CZ2011767A3
(cs)
|
2011-11-24 |
2013-06-05 |
Zentiva, K.S. |
Zpusob prípravy a izolace solí vardenafilu s kyselinami
|
|
EP2804603A1
(en)
|
2012-01-10 |
2014-11-26 |
President and Fellows of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
|
WO2013109738A1
(en)
|
2012-01-17 |
2013-07-25 |
The Trustees Of Columbia University In The City Of New York |
Novel phosphodiesterase inhibitors and uses thereof
|
|
AU2013213603B2
(en)
|
2012-01-26 |
2017-02-02 |
H. Lundbeck A/S |
PDE9 inhibitors with imidazo triazinone backbone
|
|
JP5941558B2
(ja)
|
2012-02-28 |
2016-06-29 |
株式会社ソウル製薬Seoul Pharma. Co., Ltd. |
シルデナフィルを有効成分として含有し、且つ、苦味の隠蔽された高含量速溶フィルム
|
|
HK1206726A1
(en)
|
2012-03-19 |
2016-01-15 |
Ironwood Pharmaceuticals, Inc. |
Imidazotriazinone compounds
|
|
CN103374002B
(zh)
*
|
2012-04-19 |
2015-07-15 |
山东轩竹医药科技有限公司 |
磷酸二酯酶-5抑制剂
|
|
CZ307091B6
(cs)
|
2012-09-14 |
2018-01-10 |
Zentiva, K.S. |
Stabilní farmaceutický přípravek obsahující Vardenafil hydrochlorid
|
|
ES2903151T3
(es)
|
2012-12-04 |
2022-03-31 |
Aribio Inc |
Composición que comprende inhibidor de fosfodiesterasa tipo 5 para inhibir la apoptosis de células nerviosas
|
|
KR101953735B1
(ko)
|
2012-12-14 |
2019-03-04 |
한미약품 주식회사 |
포스포다이에스터라제-5 억제제를 포함하는 츄정
|
|
EA201500852A1
(ru)
|
2013-02-21 |
2016-02-29 |
Адверио Фарма Гмбх |
Формы метил {4,6-диамино-2-[1-(2-фторбензил)-1н-пиразоло[3,4-в]пиридино-3-ил]пиримидино-5-ил}метил карбамата
|
|
CN104109164B
(zh)
*
|
2013-04-18 |
2016-05-25 |
广州朗圣药业有限公司 |
一种适合工业化的高纯度盐酸伐地那非三水合物的制备方法
|
|
ES2776353T3
(es)
|
2013-07-17 |
2020-07-30 |
Univ Columbia |
Inhibidores de la fosfodiesterasa novedosos y usos de los mismos
|
|
WO2015089105A1
(en)
|
2013-12-09 |
2015-06-18 |
Respira Therapeutics, Inc. |
Pde5 inhibitor powder formulations and methods relating thereto
|
|
PL223869B1
(pl)
|
2013-12-16 |
2016-11-30 |
Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna |
Sposób otrzymywania wardenafilu i jego soli
|
|
KR101645652B1
(ko)
|
2014-11-03 |
2016-08-08 |
(주)퓨젠바이오농업회사법인 |
세리포리아 락세라타에 의해 생산되는 세포외다당체를 유효성분으로 함유하는 성기능개선용 조성물
|
|
TN2017000507A1
(en)
|
2015-07-07 |
2019-04-12 |
H Lundbeck As |
Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
|
|
DK3377495T3
(da)
*
|
2015-11-16 |
2022-05-09 |
Topadur Pharma Ag |
2-phenyl-3,4-dihydropyrrolo[2,1-f] [1,2,4]triazinon-derivativer som phosphodiesterasehæmmere og anvendelser deraf
|
|
WO2017168174A1
(en)
|
2016-04-02 |
2017-10-05 |
N4 Pharma Uk Limited |
New pharmaceutical forms of sildenafil
|
|
WO2018112258A1
(en)
|
2016-12-14 |
2018-06-21 |
Respira Therapeutics, Inc. |
Methods and compositions for treatment of pulmonary hypertension and other lung disorders
|
|
WO2018215433A1
(en)
|
2017-05-22 |
2018-11-29 |
Topadur Pharma Ag |
Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
|
|
CN107445964A
(zh)
*
|
2017-07-29 |
2017-12-08 |
合肥创新医药技术有限公司 |
一种盐酸伐地那非杂质的合成方法
|
|
AU2018386444A1
(en)
|
2017-12-20 |
2020-07-23 |
Klaria Pharma Holding Ab |
Film formulation comprising vardenafil, method for its preparation, and use thereof
|
|
CA3090277A1
(en)
|
2018-02-02 |
2019-08-08 |
Alexza Pharmaceuticals, Inc. |
Electrical condensation aerosol device
|
|
HUE065709T2
(hu)
|
2018-05-25 |
2024-06-28 |
Cardurion Pharmaceuticals Inc |
6-[(3S,4S)-4-metil-1-(pirimidin-2-ilmetil)pirrolidin-3-il]-3-tetrahidropirán-4-il-7H-imidazo[1,5-a] pirazin-8-on vegyület monohidrát és kristályos formái
|
|
EP3807897A1
(en)
|
2018-06-14 |
2021-04-21 |
AstraZeneca UK Limited |
Methods for treating erectile dysfunction with a cgmp-specific phosphodiesterase 5 inhibitor pharmaceutical composition
|
|
CA3103716A1
(en)
|
2018-06-14 |
2019-12-19 |
Astrazeneca Uk Limited |
Methods for treating erectile dysfunction with a cgmp-specific phosphodiesterase 5 inhibitor pharmaceutical composition
|
|
CN112996512B
(zh)
|
2018-08-31 |
2025-01-03 |
卡都瑞恩医药公司 |
用于治疗镰状细胞病的pde9抑制剂
|
|
KR20210096626A
(ko)
*
|
2018-11-28 |
2021-08-05 |
토파두르 파마 아게 |
가용성 구아닐레이트 사이클라제 활성제 및 포스포디에스테라제 억제제의 신규한 이중 작용 방식 및 이의 용도
|
|
WO2020184670A1
(ja)
|
2019-03-13 |
2020-09-17 |
大塚製薬株式会社 |
二級アミンを含有する化合物のアミン部分に重水素低級アルキルを導入する方法
|
|
US11590209B2
(en)
|
2020-01-21 |
2023-02-28 |
Palatin Technologies, Inc. |
Use of bremelanotide in patients with controlled hypertension
|
|
WO2021245192A1
(en)
|
2020-06-04 |
2021-12-09 |
Topadur Pharma Ag |
Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
|
|
MX2023006911A
(es)
*
|
2020-12-11 |
2023-06-26 |
Ildong Pharmaceutical Co Ltd |
Nuevos compuestos como inhibidor dual del receptor de androgenos y de la fosfodiesterasa.
|
|
CA3214215A1
(en)
*
|
2021-04-21 |
2022-10-27 |
Yunlong Song |
Imidazole-containing condensed ring derivative, preparation method therefor, and application thereof in medicine
|
|
CN114085225A
(zh)
*
|
2021-06-04 |
2022-02-25 |
广东西捷药业有限公司 |
一种伐地那非类似物及其合成方法和应用
|
|
WO2023052407A1
(en)
|
2021-09-29 |
2023-04-06 |
Topadur Pharma Ag |
Topical compositions of 2-phenyl-3,4-dihydropyrrolo[2,l-f] [1,2,4]triazinone derivatives and uses thereof
|
|
KR20230129639A
(ko)
|
2022-03-02 |
2023-09-11 |
연세대학교 산학협력단 |
이중작용 pde5 억제제/질산유기에스터의 국소 혈류 증진을 위한 경피 투약 형태
|
|
KR20240154529A
(ko)
|
2022-03-02 |
2024-10-25 |
토파두르 파마 아게 |
국소 조성물 및 이들의 용도
|
|
TW202428579A
(zh)
*
|
2022-10-19 |
2024-07-16 |
大陸商長春金賽藥業有限責任公司 |
Nk3r拮抗劑的晶型及其製備方法和用途
|
|
WO2024173675A1
(en)
|
2023-02-16 |
2024-08-22 |
University Of Rochester |
Improving glymphatic-lymphatic efflux
|