IL283190B2 - Functionalized heterocycles as antiviral agents - Google Patents

Functionalized heterocycles as antiviral agents

Info

Publication number
IL283190B2
IL283190B2 IL283190A IL28319021A IL283190B2 IL 283190 B2 IL283190 B2 IL 283190B2 IL 283190 A IL283190 A IL 283190A IL 28319021 A IL28319021 A IL 28319021A IL 283190 B2 IL283190 B2 IL 283190B2
Authority
IL
Israel
Prior art keywords
1nnn
oxo
butyl
tert
dihydro
Prior art date
Application number
IL283190A
Other languages
English (en)
Hebrew (he)
Other versions
IL283190B1 (en
IL283190A (en
Inventor
Joseph Panarese
Dexter Davis
Samuel Bartlett
Katherine Chong
Nathaniel Kenton
Yat Sun Or
Original Assignee
Enanta Pharm Inc
Joseph Panarese
Dexter Davis
Samuel Bartlett
Katherine Chong
Nathaniel Kenton
Yat Sun Or
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc, Joseph Panarese, Dexter Davis, Samuel Bartlett, Katherine Chong, Nathaniel Kenton, Yat Sun Or filed Critical Enanta Pharm Inc
Publication of IL283190A publication Critical patent/IL283190A/en
Publication of IL283190B1 publication Critical patent/IL283190B1/en
Publication of IL283190B2 publication Critical patent/IL283190B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL283190A 2018-11-21 2019-11-20 Functionalized heterocycles as antiviral agents IL283190B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862770428P 2018-11-21 2018-11-21
US201962884486P 2019-08-08 2019-08-08
PCT/US2019/062372 WO2020106816A1 (en) 2018-11-21 2019-11-20 Functionalized heterocycles as antiviral agents

Publications (3)

Publication Number Publication Date
IL283190A IL283190A (en) 2021-06-30
IL283190B1 IL283190B1 (en) 2025-04-01
IL283190B2 true IL283190B2 (en) 2025-08-01

Family

ID=70770590

Family Applications (1)

Application Number Title Priority Date Filing Date
IL283190A IL283190B2 (en) 2018-11-21 2019-11-20 Functionalized heterocycles as antiviral agents

Country Status (17)

Country Link
US (3) US11198693B2 (enExample)
EP (1) EP3883570A4 (enExample)
JP (1) JP7536761B2 (enExample)
KR (1) KR102819704B1 (enExample)
CN (1) CN113271946A (enExample)
AU (1) AU2019385477B2 (enExample)
BR (1) BR112021009854A2 (enExample)
CA (1) CA3119973A1 (enExample)
CL (1) CL2021001288A1 (enExample)
CO (1) CO2021008055A2 (enExample)
IL (1) IL283190B2 (enExample)
MX (1) MX2021005850A (enExample)
PH (1) PH12021551116A1 (enExample)
SG (1) SG11202105007TA (enExample)
TW (1) TW202033524A (enExample)
UY (1) UY38483A (enExample)
WO (1) WO2020106816A1 (enExample)

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KR102398439B1 (ko) 2016-03-07 2022-05-16 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
EP3548035A4 (en) * 2016-11-30 2020-07-22 Case Western Reserve University COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES
CN110573154A (zh) 2017-02-06 2019-12-13 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
SG11202001685TA (en) 2017-08-28 2020-03-30 Enanta Pharm Inc Hepatitis b antiviral agents
CN111433210A (zh) * 2017-12-20 2020-07-17 诺华股份有限公司 作为抗病毒药的稠合三环吡唑并-二氢吡嗪基-吡啶酮化合物
TW202024093A (zh) 2018-09-21 2020-07-01 美商安塔製藥公司 作為抗病毒劑之官能化雜環
WO2020106998A1 (en) 2018-11-21 2020-05-28 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
EP3883570A4 (en) 2018-11-21 2022-07-13 Enanta Pharmaceuticals, Inc. FUNCTIONALIZED HETEROCYCLES AS ANTIVIRAL AGENTS
WO2020247444A1 (en) 2019-06-03 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
US11472808B2 (en) 2019-06-04 2022-10-18 Enanta Pharmaceuticals, Inc. Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents
WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2021007488A1 (en) 2019-07-11 2021-01-14 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
CN112300161B (zh) * 2019-07-30 2021-10-29 上海挚盟医药科技有限公司 一类用于治疗和/或预防乙型肝炎病毒感染的化合物及其制备方法和应用
WO2021055425A2 (en) 2019-09-17 2021-03-25 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
AU2021224268A1 (en) 2020-02-21 2022-09-15 Case Western Reserve University Compositions and methods for treating renal injury
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
EP4320117A4 (en) * 2021-04-04 2025-02-26 Baruch S. Blumberg Institute NOVEL HEPATOSELECTIVE INHIBITORS OF POLYADENYLATION POLYMERASE AND METHOD OF USE THEREOF
WO2023230249A1 (en) * 2022-05-25 2023-11-30 Baruch S. Blumberg Institute Novel hepatoselective polyadenylating polymerases inhibitors and their method of use

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN108530449A (zh) * 2017-05-22 2018-09-14 河南春风医药科技有限公司 用于治疗或预防乙型肝炎病毒感染的化合物及其制备方法与应用

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