PL3468971T3 - Nowe pochodne (hetero)arylo-piperydynylowe, sposoby ich wytwarzania oraz zawierające je kompozycje - Google Patents
Nowe pochodne (hetero)arylo-piperydynylowe, sposoby ich wytwarzania oraz zawierające je kompozycjeInfo
- Publication number
- PL3468971T3 PL3468971T3 PL17728567T PL17728567T PL3468971T3 PL 3468971 T3 PL3468971 T3 PL 3468971T3 PL 17728567 T PL17728567 T PL 17728567T PL 17728567 T PL17728567 T PL 17728567T PL 3468971 T3 PL3468971 T3 PL 3468971T3
- Authority
- PL
- Poland
- Prior art keywords
- hetero
- aryl
- preparation
- new
- methods
- Prior art date
Links
- 125000005842 heteroatom Chemical group 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1655387A FR3052451B1 (fr) | 2016-06-10 | 2016-06-10 | Nouveaux derives de piperidinyle hetero(aryl)-substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR1663463A FR3061177B1 (fr) | 2016-12-28 | 2016-12-28 | Nouveaux derives piperidinyles hetero(aryle)-substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
| EP17728567.3A EP3468971B1 (en) | 2016-06-10 | 2017-06-09 | New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| PCT/EP2017/064062 WO2017212010A1 (en) | 2016-06-10 | 2017-06-09 | New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3468971T3 true PL3468971T3 (pl) | 2020-08-10 |
Family
ID=59021522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17728567T PL3468971T3 (pl) | 2016-06-10 | 2017-06-09 | Nowe pochodne (hetero)arylo-piperydynylowe, sposoby ich wytwarzania oraz zawierające je kompozycje |
Country Status (42)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3426245B1 (en) | 2016-03-07 | 2022-12-14 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| FR3052452B1 (fr) * | 2016-06-10 | 2018-06-22 | Les Laboratoires Servier | Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU2018254577B2 (en) | 2017-04-21 | 2024-06-13 | Epizyme, Inc. | Combination therapies with EHMT2 inhibitors |
| AR112481A1 (es) | 2017-08-28 | 2019-10-30 | Enanta Pharm Inc | Agentes antivirales contra la hepatitis b |
| GB201801562D0 (en) | 2018-01-31 | 2018-03-14 | Almac Diagnostics Ltd | Pharmaceutical compounds |
| UY38291A (es) * | 2018-07-05 | 2020-06-30 | Servier Lab | Nuevos derivados de amino-pirimidonilo un proceso para su preparación y composiciones farmacéuticas |
| JP2022500466A (ja) | 2018-09-21 | 2022-01-04 | エナンタ ファーマシューティカルズ インコーポレイテッド | 抗ウイルス剤としての官能化複素環 |
| UY38423A (es) * | 2018-10-19 | 2021-02-26 | Servier Lab | Nuevos derivados amino-pirimidonil-piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| EP3883570A4 (en) | 2018-11-21 | 2022-07-13 | Enanta Pharmaceuticals, Inc. | FUNCTIONALIZED HETEROCYCLES AS ANTIVIRAL AGENTS |
| JP2022512128A (ja) * | 2018-12-06 | 2022-02-02 | アルマック・ディスカバリー・リミテッド | 医薬化合物およびユビキチン特異的プロテアーゼ１９（ｕｓｐ１９）阻害剤としてのその使用 |
| AU2020267757B2 (en) * | 2019-05-06 | 2025-03-27 | Valo Health, Inc. | Inhibiting USP19 |
| WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| WO2020247575A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2020247561A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| JP7651482B2 (ja) | 2019-07-03 | 2025-03-26 | バイエル・アクチエンゲゼルシヤフト | 殺菌薬としての置換されたチオフェンカルボキサミド類及びそれの誘導体 |
| US11738019B2 (en) | 2019-07-11 | 2023-08-29 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| CN118496197A (zh) | 2019-12-20 | 2024-08-16 | 拜耳公司 | 取代的噻吩甲酰胺、噻吩甲酸及其衍生物 |
| CN113087718B (zh) * | 2020-01-09 | 2024-02-09 | 四川科伦博泰生物医药股份有限公司 | 噻吩并嘧啶酮类化合物及其医药应用 |
| GB202001980D0 (en) | 2020-02-13 | 2020-04-01 | Almac Discovery Ltd | Therapeutic mentods |
| WO2021188414A1 (en) | 2020-03-16 | 2021-09-23 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| EP4493551A1 (en) | 2022-03-14 | 2025-01-22 | Slap Pharmaceuticals LLC | Multicyclic compounds |
| CN116574084A (zh) * | 2023-04-17 | 2023-08-11 | 华南理工大学 | 一种噻吩衍生物及其合成方法与应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2136805A2 (en) * | 2007-03-02 | 2009-12-30 | Schering Corporation | Piperidinyl-piperidine and piperazinyl-piperidine for use in the treatment of diabetes or pain |
| EP2565186A1 (en) | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| AR103297A1 (es) | 2014-12-30 | 2017-05-03 | Forma Therapeutics Inc | Pirrolo y pirazolopirimidinas como inhibidores de la proteasa 7 específica de ubiquitina |
| MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
| WO2016126926A1 (en) | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
| WO2016126935A1 (en) | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| US9932351B2 (en) | 2015-02-05 | 2018-04-03 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
-
2017
- 2017-06-09 AU AU2017277732A patent/AU2017277732B2/en not_active Ceased
- 2017-06-09 ES ES17728567T patent/ES2778700T3/es active Active
- 2017-06-09 SG SG11201810576QA patent/SG11201810576QA/en unknown
- 2017-06-09 DK DK17728567.3T patent/DK3468971T3/da active
- 2017-06-09 MD MDE20190461T patent/MD3468971T2/ro unknown
- 2017-06-09 CU CU2018000146A patent/CU20180146A7/es unknown
- 2017-06-09 SI SI201730267T patent/SI3468971T1/sl unknown
- 2017-06-09 PE PE2018003132A patent/PE20220948A1/es unknown
- 2017-06-09 BR BR112018075284-3A patent/BR112018075284A2/pt not_active Application Discontinuation
- 2017-06-09 MY MYPI2018002417A patent/MY196328A/en unknown
- 2017-06-09 CA CA3027008A patent/CA3027008C/en active Active
- 2017-06-09 WO PCT/EP2017/064062 patent/WO2017212010A1/en not_active Ceased
- 2017-06-09 LT LTEP17728567.3T patent/LT3468971T/lt unknown
- 2017-06-09 RS RS20200510A patent/RS60279B1/sr unknown
- 2017-06-09 JP JP2018564752A patent/JP6985299B2/ja not_active Expired - Fee Related
- 2017-06-09 MX MX2018015212A patent/MX374443B/es active IP Right Grant
- 2017-06-09 UA UAA201900070A patent/UA123793C2/uk unknown
- 2017-06-09 PL PL17728567T patent/PL3468971T3/pl unknown
- 2017-06-09 CR CR20180563A patent/CR20180563A/es unknown
- 2017-06-09 RU RU2018147424A patent/RU2742271C2/ru active
- 2017-06-09 HU HUE17728567A patent/HUE048590T2/hu unknown
- 2017-06-09 HR HRP20200556TT patent/HRP20200556T1/hr unknown
- 2017-06-09 TW TW106119243A patent/TWI647228B/zh not_active IP Right Cessation
- 2017-06-09 CN CN201780047088.4A patent/CN109563094B/zh active Active
- 2017-06-09 TN TNP/2018/000395A patent/TN2018000395A1/en unknown
- 2017-06-09 GE GEAP202014982A patent/GEAP202014982A/en unknown
- 2017-06-09 GE GEAP201714982A patent/GEP20207161B/en unknown
- 2017-06-09 KR KR1020197000798A patent/KR102003532B1/ko active Active
- 2017-06-09 US US16/306,941 patent/US10654849B2/en active Active
- 2017-06-09 UY UY0001037289A patent/UY37289A/es unknown
- 2017-06-09 EP EP17728567.3A patent/EP3468971B1/en active Active
- 2017-06-09 PT PT177285673T patent/PT3468971T/pt unknown
- 2017-06-09 MA MA45223A patent/MA45223B1/fr unknown
-
2018
- 2018-11-28 PH PH12018502516A patent/PH12018502516B1/en unknown
- 2018-11-29 SV SV2018005792A patent/SV2018005792A/es unknown
- 2018-12-03 DO DO2018000264A patent/DOP2018000264A/es unknown
- 2018-12-03 IL IL263455A patent/IL263455B/en active IP Right Grant
- 2018-12-04 CL CL2018003473A patent/CL2018003473A1/es unknown
- 2018-12-04 EC ECSENADI201890046A patent/ECSP18090046A/es unknown
- 2018-12-04 CO CONC2018/0013141A patent/CO2018013141A2/es unknown
- 2018-12-07 ZA ZA2018/08286A patent/ZA201808286B/en unknown
- 2018-12-07 NI NI201800133A patent/NI201800133A/es unknown
-
2020
- 2020-05-18 CY CY20201100451T patent/CY1123069T1/el unknown
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