AU2019385477B2 - Functionalized heterocycles as antiviral agents - Google Patents

Functionalized heterocycles as antiviral agents Download PDF

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Publication number
AU2019385477B2
AU2019385477B2 AU2019385477A AU2019385477A AU2019385477B2 AU 2019385477 B2 AU2019385477 B2 AU 2019385477B2 AU 2019385477 A AU2019385477 A AU 2019385477A AU 2019385477 A AU2019385477 A AU 2019385477A AU 2019385477 B2 AU2019385477 B2 AU 2019385477B2
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Prior art keywords
oxo
dihydro
pyrazine
pyrido
pyrazolo
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AU2019385477A1 (en
Inventor
Samuel Bartlett
Katherine CHONG
Dexter DAVIS
Nathaniel KENTON
Yat Sun Or
Joseph PANARESE
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Enanta Pharmaceuticals Inc
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Enanta Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2019385477A 2018-11-21 2019-11-20 Functionalized heterocycles as antiviral agents Active AU2019385477B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862770428P 2018-11-21 2018-11-21
US62/770,428 2018-11-21
US201962884486P 2019-08-08 2019-08-08
US62/884,486 2019-08-08
PCT/US2019/062372 WO2020106816A1 (en) 2018-11-21 2019-11-20 Functionalized heterocycles as antiviral agents

Publications (2)

Publication Number Publication Date
AU2019385477A1 AU2019385477A1 (en) 2021-06-10
AU2019385477B2 true AU2019385477B2 (en) 2025-02-06

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AU2019385477A Active AU2019385477B2 (en) 2018-11-21 2019-11-20 Functionalized heterocycles as antiviral agents

Country Status (17)

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US (3) US11198693B2 (enExample)
EP (1) EP3883570A4 (enExample)
JP (1) JP7536761B2 (enExample)
KR (1) KR102819704B1 (enExample)
CN (1) CN113271946A (enExample)
AU (1) AU2019385477B2 (enExample)
BR (1) BR112021009854A2 (enExample)
CA (1) CA3119973A1 (enExample)
CL (1) CL2021001288A1 (enExample)
CO (1) CO2021008055A2 (enExample)
IL (1) IL283190B2 (enExample)
MX (1) MX2021005850A (enExample)
PH (1) PH12021551116A1 (enExample)
SG (1) SG11202105007TA (enExample)
TW (1) TW202033524A (enExample)
UY (1) UY38483A (enExample)
WO (1) WO2020106816A1 (enExample)

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AU2018215678A1 (en) 2017-02-06 2019-08-22 Board Of Regents Of The University Of Texas System Compositions and methods of modulating short-chain dehydrogenase activity
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CA3113235A1 (en) 2018-09-21 2020-03-26 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
IL283190B2 (en) 2018-11-21 2025-08-01 Enanta Pharm Inc Functionalized heterocycles as antiviral agents
IL321451A (en) 2018-11-21 2025-08-01 Univ Case Western Reserve Compositions and methods of modulating short-chain dehydrogenase activity
US11236111B2 (en) 2019-06-03 2022-02-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2020247575A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2021007488A1 (en) 2019-07-11 2021-01-14 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2021018207A1 (zh) * 2019-07-30 2021-02-04 上海挚盟医药科技有限公司 一类用于治疗和/或预防乙型肝炎病毒感染的化合物及其制备方法和应用
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
MX2022010258A (es) 2020-02-21 2023-01-24 Univ Case Western Reserve Composiciones y métodos para tratar la lesión renal.
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
CN117279909A (zh) * 2021-04-04 2023-12-22 巴鲁克斯布伦博格研究所 新型肝选择性聚腺苷酸化聚合酶抑制剂及其使用方法
WO2023230249A1 (en) * 2022-05-25 2023-11-30 Baruch S. Blumberg Institute Novel hepatoselective polyadenylating polymerases inhibitors and their method of use

Citations (3)

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CN108530449A (zh) * 2017-05-22 2018-09-14 河南春风医药科技有限公司 用于治疗或预防乙型肝炎病毒感染的化合物及其制备方法与应用
US20180312507A1 (en) * 2017-04-27 2018-11-01 Novartis Ag Fused indazole pyridone compounds as antivirals
WO2019123285A1 (en) * 2017-12-20 2019-06-27 Novartis Ag Fused tricyclic pyrazolo-dihydropyrazinyl-pyridone compounds as antivirals

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