|
KR102444509B1
(ko)
|
2016-05-18 |
2022-09-19 |
미라티 테라퓨틱스, 인크. |
Kras g12c 억제제
|
|
CN110366550A
(zh)
|
2016-12-22 |
2019-10-22 |
美国安进公司 |
作为用于治疗肺癌、胰腺癌或结直肠癌的KRAS G12C抑制剂的苯并异噻唑、异噻唑并[3,4-b]吡啶、喹唑啉、酞嗪、吡啶并[2,3-d]哒嗪和吡啶并[2,3-d]嘧啶衍生物
|
|
AU2018273356B2
(en)
|
2017-05-22 |
2021-09-16 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
AU2018329920B2
(en)
|
2017-09-08 |
2022-12-01 |
Amgen Inc. |
Inhibitors of KRAS G12C and methods of using the same
|
|
US10647715B2
(en)
|
2017-11-15 |
2020-05-12 |
Mirati Therapeutics, Inc. |
KRas G12C inhibitors
|
|
LT3710439T
(lt)
*
|
2017-11-15 |
2023-05-10 |
Mirati Therapeutics, Inc. |
Kras g12c inhibitoriai
|
|
US10597405B2
(en)
|
2017-12-08 |
2020-03-24 |
Astrazeneca Ab |
Chemical compounds
|
|
EP3842433B1
(en)
|
2018-01-19 |
2023-11-01 |
Medshine Discovery Inc. |
Pyridone-pyrimidine derivative acting as krasg12c mutein inhibitor
|
|
TW201942115A
(zh)
|
2018-02-01 |
2019-11-01 |
美商輝瑞股份有限公司 |
作為抗癌藥之經取代的喹唑啉和吡啶並嘧啶衍生物
|
|
TW201942116A
(zh)
*
|
2018-02-09 |
2019-11-01 |
美商輝瑞股份有限公司 |
作為抗癌劑之四氫喹唑啉衍生物
|
|
WO2019195609A2
(en)
|
2018-04-04 |
2019-10-10 |
Arvinas Operations, Inc. |
Modulators of proteolysis and associated methods of use
|
|
EP3788053B1
(en)
|
2018-05-04 |
2024-07-10 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
CA3098574A1
(en)
*
|
2018-05-04 |
2019-11-07 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
WO2019217307A1
(en)
|
2018-05-07 |
2019-11-14 |
Mirati Therapeutics, Inc. |
Kras g12c inhibitors
|
|
TW202012415A
(zh)
|
2018-05-08 |
2020-04-01 |
瑞典商阿斯特捷利康公司 |
化學化合物
|
|
MA52564A
(fr)
|
2018-05-10 |
2021-03-17 |
Amgen Inc |
Inhibiteurs de kras g12c pour le traitement du cancer
|
|
US11096939B2
(en)
|
2018-06-01 |
2021-08-24 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
MX2020012204A
(es)
|
2018-06-11 |
2021-03-31 |
Amgen Inc |
Inhibidores de kras g12c para tratar el cáncer.
|
|
US11285156B2
(en)
|
2018-06-12 |
2022-03-29 |
Amgen Inc. |
Substituted piperazines as KRAS G12C inhibitors
|
|
AU2019320945C1
(en)
|
2018-08-16 |
2021-09-30 |
F. Hoffmann-La Roche Ag |
Fused ring compounds
|
|
ES2961253T3
(es)
*
|
2018-08-31 |
2024-03-11 |
Mirati Therapeutics Inc |
Inhibidores de KRas G12C
|
|
JP2022500385A
(ja)
*
|
2018-09-10 |
2022-01-04 |
ミラティ セラピューティクス, インコーポレイテッド |
組み合わせ療法
|
|
EA202190749A1
(ru)
*
|
2018-09-10 |
2021-07-09 |
Мирати Терапьютикс, Инк. |
Способы комбинированной терапии
|
|
EP3849535A4
(en)
*
|
2018-09-10 |
2022-06-29 |
Mirati Therapeutics, Inc. |
Combination therapies
|
|
ES3017461T3
(en)
*
|
2018-09-10 |
2025-05-13 |
Mirati Therapeutics Inc |
Combination of dasatinib and adagrasib for use in the treatment of non-small cell lung cancer
|
|
EP3849537B1
(en)
|
2018-09-10 |
2024-10-23 |
Mirati Therapeutics, Inc. |
Combination therapies
|
|
CR20210175A
(es)
|
2018-09-18 |
2021-06-01 |
Nikang Therapeutics Inc |
Derivados de anillo tricíclico condensado como inhibidores de la fosfatasa de homología a src 2 (shp2)
|
|
CN114042070A
(zh)
|
2018-09-30 |
2022-02-15 |
凯瑞康宁生物工程(武汉)有限公司 |
作为神经元组胺受体-3拮抗剂的化合物及其用途
|
|
WO2020085504A1
(ja)
|
2018-10-26 |
2020-04-30 |
大鵬薬品工業株式会社 |
光照射ザンドマイヤー反応を用いたクロロアゾールカルボキシレート誘導体の製造方法
|
|
PE20260440A1
(es)
|
2018-11-09 |
2026-02-19 |
Hoffmann La Roche |
Compuestos de anillo fusionado
|
|
JP7516029B2
(ja)
|
2018-11-16 |
2024-07-16 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤化合物の重要な中間体の改良合成法
|
|
AU2019384118B2
(en)
|
2018-11-19 |
2025-06-12 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
JP7377679B2
(ja)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法
|
|
MX2021002804A
(es)
*
|
2018-12-05 |
2021-07-15 |
Mirati Therapeutics Inc |
Terapias de combinacion.
|
|
EP3908283A4
(en)
|
2019-01-10 |
2022-10-12 |
Mirati Therapeutics, Inc. |
KRAS G12C INHIBITORS
|
|
US20220152026A1
(en)
|
2019-02-12 |
2022-05-19 |
Novartis Ag |
Pharmaceutical combination comprising tno155 and a krasg12c inhibitor
|
|
KR102934231B1
(ko)
|
2019-03-05 |
2026-03-06 |
아스트라제네카 아베 |
항암제로 유용한 융합 삼환식 화합물
|
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
|
JP7502337B2
(ja)
*
|
2019-05-20 |
2024-06-18 |
カリフォルニア インスティチュート オブ テクノロジー |
Kras g12cインヒビター及びその使用
|
|
WO2020236947A1
(en)
|
2019-05-21 |
2020-11-26 |
Amgen Inc. |
Solid state forms
|
|
AU2020277398B2
(en)
|
2019-05-21 |
2026-01-29 |
Amgen Inc. |
Solid state forms
|
|
WO2020234103A1
(en)
|
2019-05-21 |
2020-11-26 |
Bayer Aktiengesellschaft |
Identification and use of kras inhibitors
|
|
TW202110837A
(zh)
*
|
2019-05-24 |
2021-03-16 |
大陸商江蘇恆瑞醫藥股份有限公司 |
氫化吡啶并嘧啶類衍生物、其製備方法及其在醫藥上的應用
|
|
WO2020239077A1
(zh)
*
|
2019-05-29 |
2020-12-03 |
上海翰森生物医药科技有限公司 |
含氮杂环类衍生物调节剂、其制备方法和应用
|
|
CN112047939B
(zh)
*
|
2019-06-06 |
2023-05-02 |
江苏先声药业有限公司 |
一种具有抗肿瘤活性的四氢吡啶并嘧啶类化合物
|
|
WO2021000885A1
(zh)
*
|
2019-07-01 |
2021-01-07 |
江苏恒瑞医药股份有限公司 |
喹唑啉酮类衍生物、其制备方法及其在医药上的应用
|
|
CN112300153B
(zh)
*
|
2019-07-26 |
2023-06-13 |
博瑞生物医药(苏州)股份有限公司 |
一种杂环化合物、药物组合物和用途
|
|
CN112390788A
(zh)
*
|
2019-08-13 |
2021-02-23 |
苏州闻天医药科技有限公司 |
一种用于抑制krasg12c突变蛋白的化合物及其制备方法和用途
|
|
CN112390797A
(zh)
*
|
2019-08-15 |
2021-02-23 |
微境生物医药科技(上海)有限公司 |
新型螺环类K-Ras G12C抑制剂
|
|
CN112390796B
(zh)
*
|
2019-08-19 |
2023-06-27 |
贝达药业股份有限公司 |
Kras g12c抑制剂及其在医药上的应用
|
|
CN112430234B
(zh)
*
|
2019-08-26 |
2023-04-28 |
信达生物制药(苏州)有限公司 |
一种新型kras g12c蛋白抑制剂及其制备方法和用途
|
|
MX2022002465A
(es)
|
2019-08-29 |
2022-05-19 |
Mirati Therapeutics Inc |
Inhibidores de kras g12d.
|
|
WO2021043322A1
(zh)
*
|
2019-09-06 |
2021-03-11 |
正大天晴药业集团南京顺欣制药有限公司 |
氮杂环庚烷并嘧啶类衍生物及其医药用途
|
|
US20220402916A1
(en)
*
|
2019-09-18 |
2022-12-22 |
Merck Sharp & Dohme Corp. |
Small molecule inhibitors of kras g12c mutant
|
|
US12122787B2
(en)
|
2019-09-20 |
2024-10-22 |
Shanghai Jemincare Pharmaceuticals Co., Ltd |
Fused pyridone compound, and preparation method therefor and use thereof
|
|
CN112538084B
(zh)
*
|
2019-09-23 |
2023-06-20 |
信达生物制药(苏州)有限公司 |
新颖的kras g12c蛋白抑制剂及其制备方法和用途
|
|
WO2021061749A1
(en)
|
2019-09-24 |
2021-04-01 |
Mirati Therapeutics, Inc. |
Combination therapies
|
|
CN114555586B
(zh)
*
|
2019-10-10 |
2023-06-23 |
信达生物制药(苏州)有限公司 |
Krasg12c蛋白抑制剂及其制备方法和用途
|
|
CN112694475B
(zh)
|
2019-10-23 |
2025-09-23 |
苏州泽璟生物制药股份有限公司 |
环烷基类和杂环烷基类抑制剂及其制备方法和应用
|
|
UA129778C2
(uk)
|
2019-10-28 |
2025-07-30 |
Мерк Шарп Енд Доум Елелсі |
Низькомолекулярні інгібітори g12c-мутантного kras
|
|
AU2020377925A1
(en)
|
2019-11-04 |
2022-05-05 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
IL322454A
(en)
|
2019-11-04 |
2025-09-01 |
Revolution Medicines Inc |
ras inhibitors
|
|
TW202132316A
(zh)
|
2019-11-04 |
2021-09-01 |
美商銳新醫藥公司 |
Ras抑制劑
|
|
CN112778301A
(zh)
*
|
2019-11-07 |
2021-05-11 |
苏州泽璟生物制药股份有限公司 |
四氢吡啶并嘧啶类抑制剂及其制备方法和应用
|
|
CN114630832A
(zh)
*
|
2019-11-15 |
2022-06-14 |
四川海思科制药有限公司 |
一种嘧啶并环衍生物及其在医药上的应用
|
|
CN112824410A
(zh)
*
|
2019-11-21 |
2021-05-21 |
苏州泽璟生物制药股份有限公司 |
氮杂七元环类抑制剂及其制备方法和应用
|
|
EP4065231A1
(en)
*
|
2019-11-27 |
2022-10-05 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
|
EP4067343A4
(en)
|
2019-11-29 |
2024-01-03 |
Taiho Pharmaceutical Co., Ltd. |
NEW PHENOLIC COMPOUND OR SALT THEREOF
|
|
WO2021106231A1
(en)
*
|
2019-11-29 |
2021-06-03 |
Taiho Pharmaceutical Co., Ltd. |
A compound having inhibitory activity against kras g12d mutation
|
|
WO2021109737A1
(zh)
*
|
2019-12-02 |
2021-06-10 |
上海璎黎药业有限公司 |
一种含氧杂环化合物、其制备方法及应用
|
|
CN112979664B
(zh)
*
|
2019-12-02 |
2024-03-01 |
上海璎黎药业有限公司 |
一种含氧杂环化合物、其制备方法及应用
|
|
PH12022551513A1
(en)
|
2019-12-20 |
2023-04-24 |
Mirati Therapeutics Inc |
Sos1 inhibitors
|
|
WO2021120890A1
(en)
|
2019-12-20 |
2021-06-24 |
Novartis Ag |
Pyrazolyl derivatives useful as anti-cancer agents
|
|
CN113045565A
(zh)
*
|
2019-12-27 |
2021-06-29 |
微境生物医药科技(上海)有限公司 |
新型K-Ras G12C抑制剂
|
|
CN112094269B
(zh)
*
|
2020-01-01 |
2021-12-07 |
上海凌达生物医药有限公司 |
一类饱和六元环并杂环类化合物、制备方法和用途
|
|
GB202001344D0
(en)
|
2020-01-31 |
2020-03-18 |
Redx Pharma Plc |
Ras Inhibitors
|
|
CN115135650A
(zh)
*
|
2020-02-20 |
2022-09-30 |
贝达医药公司 |
作为kras抑制剂的吡啶并嘧啶衍生物
|
|
AU2021233058B2
(en)
*
|
2020-03-12 |
2024-05-16 |
D3 Bio(Wuxi) Co., Ltd |
Pyrimidoheterocyclic compounds and application thereof
|
|
TWI811656B
(zh)
*
|
2020-04-22 |
2023-08-11 |
大陸商德昇濟醫藥(無錫)有限公司 |
嘧啶并雜環類化合物及其應用
|
|
WO2021219072A1
(zh)
*
|
2020-04-30 |
2021-11-04 |
上海科州药物研发有限公司 |
作为kras抑制剂的杂环化合物的制备及其应用方法
|
|
US11739102B2
(en)
|
2020-05-13 |
2023-08-29 |
Incyte Corporation |
Fused pyrimidine compounds as KRAS inhibitors
|
|
CN113666923A
(zh)
*
|
2020-05-15 |
2021-11-19 |
苏州泽璟生物制药股份有限公司 |
烷氧基烷基取代杂环基类抑制剂及其制备方法和应用
|
|
CN113683616B
(zh)
*
|
2020-05-18 |
2025-12-30 |
广州百霆医药科技有限公司 |
Kras g12c突变蛋白抑制剂
|
|
JP7808058B2
(ja)
*
|
2020-06-02 |
2026-01-28 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
がんを治療するための縮合環化2-アミノ-3-シアノチオフェン及び誘導体
|
|
CN111646910A
(zh)
*
|
2020-06-15 |
2020-09-11 |
中国药科大学 |
一种盐酸达泊西汀消旋体的制备方法
|
|
IL299131A
(en)
|
2020-06-18 |
2023-02-01 |
Revolution Medicines Inc |
Methods for delaying, preventing and treating acquired resistance to RAS inhibitors
|
|
CN115942936A
(zh)
|
2020-06-24 |
2023-04-07 |
勃林格殷格翰国际有限公司 |
包含sos1抑制剂和kras g12c抑制剂的抗癌组合疗法
|
|
CN113912608B
(zh)
*
|
2020-07-10 |
2023-07-14 |
江苏恒瑞医药股份有限公司 |
嘧啶并嘧啶酮类衍生物、其制备方法及其在医药上的应用
|
|
CN113980014B
(zh)
*
|
2020-07-27 |
2023-05-12 |
江苏恒瑞医药股份有限公司 |
氢化吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用
|
|
US20250195521A1
(en)
|
2020-09-03 |
2025-06-19 |
Revolution Medicines, Inc. |
Use of sos1 inhibitors to treat malignancies with shp2 mutations
|
|
WO2022052895A1
(zh)
|
2020-09-11 |
2022-03-17 |
南京明德新药研发有限公司 |
氮杂环丁烷取代化合物的晶型
|
|
EP4210833A4
(en)
|
2020-09-11 |
2024-09-11 |
Mirati Therapeutics, Inc. |
CRYSTALLINE FORMS OF A KRAS G12C INHIBITOR
|
|
CA3194067A1
(en)
|
2020-09-15 |
2022-03-24 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
US20230357277A1
(en)
*
|
2020-09-22 |
2023-11-09 |
Mirati Therapeutics, Inc. |
Kras g12d inhibitors
|
|
JP2023544450A
(ja)
|
2020-09-23 |
2023-10-23 |
エラスカ・インコーポレイテッド |
三環式ピリドン及びピリミドン
|
|
WO2022068921A1
(zh)
*
|
2020-09-30 |
2022-04-07 |
上海医药集团股份有限公司 |
一种喹唑啉类化合物及其应用
|
|
MX2023004373A
(es)
*
|
2020-10-14 |
2023-07-07 |
Ranok Therapeutics Hangzhou Co Ltd |
Metodos y composiciones para la degradacion dirigida de proteinas.
|
|
US20240059703A1
(en)
|
2020-10-20 |
2024-02-22 |
Amgen Inc. |
Heterocyclic spiro compounds and methods of use
|
|
WO2022087375A1
(en)
*
|
2020-10-22 |
2022-04-28 |
Spectrum Pharmaceuticals, Inc. |
Novel heterocyclic compounds
|
|
WO2022087371A1
(en)
*
|
2020-10-22 |
2022-04-28 |
Spectrum Pharmaceuticals, Inc. |
Novel bicyclic compounds
|
|
WO2022105855A1
(en)
*
|
2020-11-20 |
2022-05-27 |
Jacobio Pharmaceuticals Co., Ltd. |
Kras g12d inhibitors
|
|
EP4247807A4
(en)
*
|
2020-11-23 |
2024-10-16 |
Merck Sharp & Dohme LLC |
6,7-DIHYDRO-PYRANO[2,3-D PYRIMIDINE AS INHIBITORS OF THE KRAS G12C MUTANT
|
|
KR102503336B1
(ko)
|
2020-11-23 |
2023-02-23 |
동의대학교 산학협력단 |
음성지원이 가능한 반려동물의 배변 처리 패드
|
|
CN116829151A
(zh)
*
|
2020-12-15 |
2023-09-29 |
米拉蒂治疗股份有限公司 |
氮杂喹唑啉泛KRas抑制剂
|
|
JP2023553492A
(ja)
|
2020-12-15 |
2023-12-21 |
ミラティ セラピューティクス, インコーポレイテッド |
アザキナゾリン汎KRas阻害剤
|
|
EP4262803A4
(en)
|
2020-12-16 |
2025-03-12 |
Mirati Therapeutics, Inc. |
Tetrahydropyridopyrimidine pan-kras inhibitors
|
|
WO2022133345A1
(en)
|
2020-12-18 |
2022-06-23 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
US20240100172A1
(en)
|
2020-12-21 |
2024-03-28 |
Hangzhou Jijing Pharmaceutical Technology Limited |
Methods and compounds for targeted autophagy
|
|
WO2022140472A1
(en)
|
2020-12-22 |
2022-06-30 |
Nikang Therapeutics, Inc. |
Compounds for degrading cyclin-dependent kinase 2 via ubiquitin proteosome pathway
|
|
US20240092803A1
(en)
*
|
2021-01-08 |
2024-03-21 |
Beigene Switzerland Gmbh |
Bridged compounds as kras g12d inhibitor and degrader and the use thereof
|
|
MX2023009037A
(es)
*
|
2021-02-01 |
2023-08-10 |
Medshine Discovery Inc |
Compuesto de pirimidopirano.
|
|
CN116600808B
(zh)
*
|
2021-02-09 |
2024-10-22 |
苏州阿尔脉生物科技有限公司 |
一类作为kras突变体g12c抑制剂的四氢萘啶类衍生物、其制备方法及其应用
|
|
WO2022171143A1
(zh)
*
|
2021-02-09 |
2022-08-18 |
南京明德新药研发有限公司 |
5,6,7,8-四氢吡啶[3,4-d]嘧啶化合物
|
|
JP2024509280A
(ja)
*
|
2021-03-10 |
2024-02-29 |
ベータ・ファーマ・インコーポレイテッド |
Kras阻害物質としてのピリドピリミジン誘導体
|
|
WO2022194192A1
(zh)
*
|
2021-03-18 |
2022-09-22 |
四川科伦博泰生物医药股份有限公司 |
一类杂芳环化合物、其制备方法及用途
|
|
WO2022204112A1
(en)
|
2021-03-22 |
2022-09-29 |
Incyte Corporation |
Imidazole and triazole kras inhibitors
|
|
CN115124524A
(zh)
*
|
2021-03-26 |
2022-09-30 |
浙江海正药业股份有限公司 |
三环类衍生物及其制备方法和用途
|
|
WO2022216648A1
(en)
|
2021-04-08 |
2022-10-13 |
Mirati Therapeutics, Inc. |
Combination therapies using prmt5 inhibitors for the treatment of cancer
|
|
WO2022217042A1
(en)
*
|
2021-04-09 |
2022-10-13 |
Ikena Oncology, Inc. |
Naphthyl-substituted quinoline-4(1h)-ones and related compounds and their use in treating medical conditions
|
|
JP2024514127A
(ja)
|
2021-04-09 |
2024-03-28 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
抗がん剤療法
|
|
EP4322954A4
(en)
*
|
2021-04-16 |
2025-01-29 |
Merck Sharp & Dohme LLC |
SMALL MOLECULAR INHIBITORS OF THE KRAS G12D MUTANT
|
|
EP4322945A4
(en)
*
|
2021-04-16 |
2025-07-16 |
Mirati Therapeutics Inc |
KRAS G12C INHIBITORS
|
|
CN117203208A
(zh)
*
|
2021-04-23 |
2023-12-08 |
清华大学 |
靶向活化与失活态kras g12d的抑制剂
|
|
CN117203207A
(zh)
*
|
2021-04-30 |
2023-12-08 |
江苏恒瑞医药股份有限公司 |
桥环类化合物、其制备方法及其在医药上的应用
|
|
TW202309052A
(zh)
|
2021-05-05 |
2023-03-01 |
美商銳新醫藥公司 |
Ras抑制劑
|
|
KR20240017811A
(ko)
|
2021-05-05 |
2024-02-08 |
레볼루션 메디슨즈, 인크. |
암의 치료를 위한 ras 억제제
|
|
US12280055B2
(en)
|
2021-05-27 |
2025-04-22 |
Mirati Therapeutics, Inc. |
Combination therapies
|
|
EP4347041A1
(en)
*
|
2021-05-28 |
2024-04-10 |
Taiho Pharmaceutical Co., Ltd. |
Small molecule inhibitors of kras mutated proteins
|
|
WO2022261210A1
(en)
*
|
2021-06-08 |
2022-12-15 |
Quanta Therapeutics, Inc. |
Kras modulators and uses thereof
|
|
WO2022266206A1
(en)
|
2021-06-16 |
2022-12-22 |
Erasca, Inc. |
Kras inhibitor conjugates
|
|
WO2022271823A1
(en)
*
|
2021-06-23 |
2022-12-29 |
Newave Pharmaceutical Inc. |
Mutant kras modulators and uses thereof
|
|
TW202317100A
(zh)
|
2021-06-23 |
2023-05-01 |
瑞士商諾華公司 |
包含kras g12c抑制劑的藥物組合及其用於治療癌症之用途
|
|
EP4359081A1
(en)
|
2021-06-23 |
2024-05-01 |
Novartis AG |
Pyrazolyl derivatives as inhibitors of the kras mutant protein
|
|
CN117460737A
(zh)
*
|
2021-07-05 |
2024-01-26 |
四川科伦博泰生物医药股份有限公司 |
杂芳环化合物、其制备方法及用途
|
|
MX2024000357A
(es)
|
2021-07-07 |
2024-02-12 |
Incyte Corp |
Compuestos triciclicos como inhibidores de homologo de oncogen viral de sarcoma de rata kirsten (kras).
|
|
WO2023287896A1
(en)
|
2021-07-14 |
2023-01-19 |
Incyte Corporation |
Tricyclic compounds as inhibitors of kras
|
|
TW202317589A
(zh)
|
2021-07-14 |
2023-05-01 |
美商尼坎醫療公司 |
作為kras抑制劑的伸烷基衍生物
|
|
WO2023284537A1
(en)
*
|
2021-07-16 |
2023-01-19 |
Shanghai Zion Pharma Co. Limited |
Kras g12d inhibitors and uses thereof
|
|
WO2023283933A1
(en)
*
|
2021-07-16 |
2023-01-19 |
Silexon Biotech Co., Ltd. |
Compounds useful as kras g12d inhibitors
|
|
KR20240041917A
(ko)
|
2021-07-27 |
2024-04-01 |
도레이 카부시키가이샤 |
암의 치료 및/또는 예방을 위한 의약품
|
|
US12441742B2
(en)
|
2021-08-31 |
2025-10-14 |
Incyte Corporation |
Naphthyridine compounds as inhibitors of KRAS
|
|
KR20240055778A
(ko)
|
2021-09-01 |
2024-04-29 |
노파르티스 아게 |
Tead 억제제를 포함하는 제약 조합물 및 암의 치료를 위한 이의 용도
|
|
EP4389751A1
(en)
*
|
2021-09-03 |
2024-06-26 |
Kumquat Biosciences Inc. |
Heterocyclic compounds and uses thereof
|
|
WO2023040989A1
(en)
*
|
2021-09-16 |
2023-03-23 |
Suzhou Zanrong Pharma Limited |
Kras g12c inhibitors and uses thereof
|
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
|
MX2024004846A
(es)
|
2021-10-22 |
2024-05-03 |
Jiangsu Hengrui Pharmaceuticals Co Ltd |
Compuesto tetraciclico que contiene nitrogeno, metodo de preparacion del mismo y uso medico del mismo.
|
|
IL312381A
(en)
*
|
2021-11-05 |
2024-06-01 |
Frontier Medicines Corp |
KRAS G12C inhibitors
|
|
WO2023099624A1
(en)
|
2021-12-01 |
2023-06-08 |
Boehringer Ingelheim International Gmbh |
Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
|
|
CN117940436A
(zh)
*
|
2021-12-02 |
2024-04-26 |
上海和誉生物医药科技有限公司 |
一种7-(萘-1-基)吡啶并[4,3-d]嘧啶衍生物及其制备和应用
|
|
WO2023098425A1
(zh)
*
|
2021-12-02 |
2023-06-08 |
上海和誉生物医药科技有限公司 |
一种kras抑制剂及其制备和在药学上的应用
|
|
CN119212994A
(zh)
|
2021-12-17 |
2024-12-27 |
建新公司 |
作为shp2抑制剂的吡唑并吡嗪化合物
|
|
TW202340202A
(zh)
|
2021-12-22 |
2023-10-16 |
美國加利福尼亞大學董事會 |
Gtp酶抑制劑及其用途
|
|
WO2023117681A1
(en)
|
2021-12-22 |
2023-06-29 |
Boehringer Ingelheim International Gmbh |
Heteroaromatic compounds for the treatment of cancer
|
|
CN116410145A
(zh)
*
|
2021-12-29 |
2023-07-11 |
上海泓博智源医药股份有限公司 |
一种mrtx849中间体的制备方法
|
|
WO2023125989A1
(zh)
*
|
2021-12-31 |
2023-07-06 |
上海医药集团股份有限公司 |
一种喹唑啉类化合物及其应用
|
|
WO2023137223A1
(en)
*
|
2022-01-17 |
2023-07-20 |
Newave Pharmaceutical Inc. |
Pan-kras inhibitors and uses thereof
|
|
CN118556063A
(zh)
*
|
2022-01-21 |
2024-08-27 |
上海湃隆生物科技有限公司 |
杂环类化合物、药物组合物及其应用
|
|
CA3243798A1
(en)
|
2022-02-09 |
2023-08-17 |
Quanta Therapeutics, Inc. |
Kras Modulators and Their Uses
|
|
WO2023152255A1
(en)
|
2022-02-10 |
2023-08-17 |
Bayer Aktiengesellschaft |
Fused pyrimidines as kras inhibitors
|
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
JP2025510572A
(ja)
|
2022-03-08 |
2025-04-15 |
レボリューション メディシンズ インコーポレイテッド |
免疫不応性肺癌を治療するための方法
|
|
CN116891514A
(zh)
*
|
2022-04-06 |
2023-10-17 |
润佳(苏州)医药科技有限公司 |
一种双官能化合物及其用途
|
|
CN119053595A
(zh)
|
2022-03-28 |
2024-11-29 |
尼坎治疗公司 |
作为细胞周期蛋白依赖性激酶2抑制剂的磺酰氨基衍生物
|
|
EP4504203A1
(en)
|
2022-04-04 |
2025-02-12 |
Sanofi |
Therapeutic combination of kras g12c inhibitor and tead inhibitor
|
|
CN116891488B
(zh)
*
|
2022-04-11 |
2025-12-12 |
成都海博为药业有限公司 |
稠环化合物、包含其的药物组合物及应用
|
|
WO2023199180A1
(en)
|
2022-04-11 |
2023-10-19 |
Novartis Ag |
Therapeutic uses of a krasg12c inhibitor
|
|
WO2023220421A1
(en)
*
|
2022-05-13 |
2023-11-16 |
Ranok Therapeutics (Hangzhou) Co. Ltd. |
Inhibitors of kras(g12d)
|
|
WO2023230190A1
(en)
|
2022-05-25 |
2023-11-30 |
Quanta Therapeutics, Inc. |
Pyrimidine based modulators and uses thereof
|
|
CN117164580A
(zh)
*
|
2022-05-27 |
2023-12-05 |
苏州泽璟生物制药股份有限公司 |
一种kras g12c抑制剂的制备方法及其中间体
|
|
CN119790053A
(zh)
|
2022-06-08 |
2025-04-08 |
霖康疗法公司 |
作为细胞周期蛋白依赖性激酶2抑制剂的磺酰胺衍生物
|
|
WO2023240263A1
(en)
|
2022-06-10 |
2023-12-14 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
|
KR20250024833A
(ko)
*
|
2022-06-14 |
2025-02-19 |
미라티 테라퓨틱스, 인크. |
테트라하이드로피리도피리미딘 PAN-Kras 억제제
|
|
JP2025525356A
(ja)
*
|
2022-06-15 |
2025-08-05 |
ミラティ セラピューティクス, インコーポレイテッド |
アザキナゾリン汎Kras阻害剤
|
|
GB202212641D0
(en)
|
2022-08-31 |
2022-10-12 |
Jazz Pharmaceuticals Ireland Ltd |
Novel compounds
|
|
JP2025531491A
(ja)
*
|
2022-09-28 |
2025-09-19 |
ミラティ セラピューティクス, インコーポレイテッド |
併用療法
|
|
WO2024081674A1
(en)
|
2022-10-11 |
2024-04-18 |
Aadi Bioscience, Inc. |
Combination therapies for the treatment of cancer
|
|
CN120659773A
(zh)
|
2022-11-09 |
2025-09-16 |
锐新医药公司 |
化合物、复合物以及其制备方法和用途
|
|
AU2023375457A1
(en)
|
2022-11-11 |
2025-05-01 |
Nikang Therapeutics, Inc. |
Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 via ubiquitin proteasome pathway
|
|
US12448399B2
(en)
|
2023-01-26 |
2025-10-21 |
Arvinas Operations, Inc. |
Cereblon-based KRAS degrading PROTACs and uses related thereto
|
|
KR20260041941A
(ko)
|
2023-03-15 |
2026-03-27 |
콴타 테라퓨틱스, 인크. |
Kras 조절 인자 및 이의 용도
|
|
AU2024241633A1
(en)
|
2023-03-30 |
2025-11-06 |
Revolution Medicines, Inc. |
Compositions for inducing ras gtp hydrolysis and uses thereof
|
|
AR132338A1
(es)
|
2023-04-07 |
2025-06-18 |
Revolution Medicines Inc |
Inhibidores de ras
|
|
CR20250420A
(es)
|
2023-04-07 |
2025-11-20 |
Revolution Medicines Inc |
Inhibidores macrocíclicos de ras
|
|
CN121100123A
(zh)
|
2023-04-14 |
2025-12-09 |
锐新医药公司 |
Ras抑制剂的结晶形式
|
|
CN121464140A
(zh)
|
2023-04-14 |
2026-02-03 |
锐新医药公司 |
Ras抑制剂的结晶形式、含有其的组合物及其使用方法
|
|
TW202508595A
(zh)
|
2023-05-04 |
2025-03-01 |
美商銳新醫藥公司 |
用於ras相關疾病或病症之組合療法
|
|
KR20240168510A
(ko)
*
|
2023-05-22 |
2024-12-02 |
주식회사 이노파마스크린 |
Kras g12d 및 g12v 돌연변이 표적 화합물 및 그 용도
|
|
CN116640104B
(zh)
*
|
2023-05-24 |
2024-04-02 |
杭州科耀医药科技有限公司 |
一种替洛利生的工业合成方法
|
|
EP4720678A1
(en)
|
2023-05-31 |
2026-04-08 |
Boehringer Ingelheim International GmbH |
Survivin as a biomarker for predicting the responsiveness of cancer treatment
|
|
EP4721766A1
(en)
|
2023-06-02 |
2026-04-08 |
Daiichi Sankyo Company, Limited |
Combination of (anti-her3 antibody)-drug conjugate and rasg12c inhibitor
|
|
CN116675690B
(zh)
*
|
2023-06-02 |
2026-03-27 |
北京康立生医药技术开发有限公司 |
一种肺癌治疗药物的制备方法
|
|
WO2025016899A1
(en)
|
2023-07-19 |
2025-01-23 |
Bayer Aktiengesellschaft |
Spirocyclic compounds for the treatment of cancer
|
|
WO2025026903A1
(en)
|
2023-07-31 |
2025-02-06 |
Bayer Aktiengesellschaft |
Imidazo pyrimidine compounds for the treatment of cancer
|
|
US20250049810A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2025072462A1
(en)
|
2023-09-27 |
2025-04-03 |
Nikang Therapeutics, Inc. |
Sulfonamide derivatives as cyclin-dependent kinase 2 inhibitors
|
|
TW202529768A
(zh)
|
2023-09-29 |
2025-08-01 |
大陸商德昇濟醫藥(無錫)有限公司 |
癌症治療的療法
|
|
AU2024360465A1
(en)
|
2023-10-12 |
2026-04-09 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
|
AU2024361909A1
(en)
|
2023-10-20 |
2026-03-26 |
Merck Sharp & Dohme Llc |
Small molecule inhibitors of kras proteins
|
|
TW202527955A
(zh)
|
2023-11-27 |
2025-07-16 |
美商尼坎醫療公司 |
用於經由泛素蛋白酶體途徑降解週期蛋白依賴性激酶2和週期蛋白依賴性激酶4的含有2,5-取代的嘧啶衍生物的雙功能化合物
|
|
WO2025117981A1
(en)
|
2023-12-02 |
2025-06-05 |
Nikang Therapeutics, Inc. |
Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 via ubiquitin proteasome pathway
|
|
US20250205238A1
(en)
|
2023-12-20 |
2025-06-26 |
Boehringer Ingelheim International Gmbh |
Anti-cancer combination therapy
|
|
WO2025145207A1
(en)
|
2023-12-29 |
2025-07-03 |
Bristol-Myers Squibb Company |
Combination therapy of kras inhibitor and treg-depleting agent
|
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025212828A1
(en)
|
2024-04-03 |
2025-10-09 |
Nikang Therapeutics, Inc. |
Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 and cyclin-dependent kinase 4 via ubiquitin proteasome pathway
|
|
WO2025240536A1
(en)
|
2024-05-15 |
2025-11-20 |
Nikang Therapeutics, Inc. |
Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 and/or cyclin-dependent kinase 4 via ubiquitin proteasome pathway
|
|
TW202547461A
(zh)
|
2024-05-17 |
2025-12-16 |
美商銳新醫藥公司 |
Ras抑制劑
|
|
WO2025255438A1
(en)
|
2024-06-07 |
2025-12-11 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2025265060A1
(en)
|
2024-06-21 |
2025-12-26 |
Revolution Medicines, Inc. |
Therapeutic compositions and methods for managing treatment-related effects
|
|
WO2026003808A1
(en)
|
2024-06-28 |
2026-01-02 |
Assia Chemical Industries Ltd. |
Solid state form of adagrasib and process for preparation
|
|
WO2026006747A1
(en)
|
2024-06-28 |
2026-01-02 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026015825A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Use of ras inhibitor for treating pancreatic cancer
|
|
WO2026015801A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015790A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015796A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026035947A1
(en)
|
2024-08-07 |
2026-02-12 |
Tesseract Medicines Us, Llc |
Kras-targeting covalent-induced drug conjugates comprising a topoisomerase payload
|
|
WO2026035945A1
(en)
|
2024-08-07 |
2026-02-12 |
Tesseract Medicines Us, Llc |
Covalent-induced drug conjugates targeting kras and comprising a topoisomerase payload
|
|
WO2026050446A1
(en)
|
2024-08-29 |
2026-03-05 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026064520A1
(en)
|
2024-09-19 |
2026-03-26 |
Tesseract Medicines Us, Llc |
Covalent-induced drug conjugates targeting kras and comprising a tubulin inhibitor payload
|
|
WO2026064527A1
(en)
|
2024-09-19 |
2026-03-26 |
Tesseract Medicines Us, Llc |
Kras-targeting covalent-induced drug conjugates comprising a tubulin inhibitor payload
|
|
WO2026072904A2
(en)
|
2024-09-26 |
2026-04-02 |
Revolution Medicines, Inc. |
Compositions and methods for treating lung cancer
|