AU2017266911B2 - KRas G12C inhibitors - Google Patents
KRas G12C inhibitors Download PDFInfo
- Publication number
- AU2017266911B2 AU2017266911B2 AU2017266911A AU2017266911A AU2017266911B2 AU 2017266911 B2 AU2017266911 B2 AU 2017266911B2 AU 2017266911 A AU2017266911 A AU 2017266911A AU 2017266911 A AU2017266911 A AU 2017266911A AU 2017266911 B2 AU2017266911 B2 AU 2017266911B2
- Authority
- AU
- Australia
- Prior art keywords
- mmol
- carcinoma
- carboxylate
- pyrimidin
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- WQMNTHTXJNWURI-HORZDZNUSA-N C/C=C/C(N(CC1)CCN1c1c(CCN(C2)c3c(cccc4)c4cc(O)c3)c2nc(OC[C@H]2N(C)CCC2)n1)=O Chemical compound C/C=C/C(N(CC1)CCN1c1c(CCN(C2)c3c(cccc4)c4cc(O)c3)c2nc(OC[C@H]2N(C)CCC2)n1)=O WQMNTHTXJNWURI-HORZDZNUSA-N 0.000 description 1
- GHJYOWQTBHLHJT-UHFFFAOYSA-N C=CC(N(CC1)CCN1c1c(CCN(C2)c3c(cccc4)c4cc(OC(CN4CCOCC4)COc4nc(N(CC5)CCN5C(C=C)=O)c(CCN(C5)c6cc(O)cc7c6nccc7)c5n4)c3)c2nc(OCCCN2CC(C3)C3C2)n1)=O Chemical compound C=CC(N(CC1)CCN1c1c(CCN(C2)c3c(cccc4)c4cc(OC(CN4CCOCC4)COc4nc(N(CC5)CCN5C(C=C)=O)c(CCN(C5)c6cc(O)cc7c6nccc7)c5n4)c3)c2nc(OCCCN2CC(C3)C3C2)n1)=O GHJYOWQTBHLHJT-UHFFFAOYSA-N 0.000 description 1
- WPJCQLIABOVULI-UHFFFAOYSA-N C=CC(N(CC1)CCN1c1c(CCN(C2)c3cc(O)cc4c3cccc4)c2nc(NC(CC2)CCN2C2CC2)n1)=O Chemical compound C=CC(N(CC1)CCN1c1c(CCN(C2)c3cc(O)cc4c3cccc4)c2nc(NC(CC2)CCN2C2CC2)n1)=O WPJCQLIABOVULI-UHFFFAOYSA-N 0.000 description 1
- BOYBAZKNDIQEJS-HSZRJFAPSA-N C=CC(N(CC1)CCN1c1nc(OCCN(CCC2)C[C@@H]2F)nc(C2)c1CCN2c1c(cccc2)c2cc(O)c1)=O Chemical compound C=CC(N(CC1)CCN1c1nc(OCCN(CCC2)C[C@@H]2F)nc(C2)c1CCN2c1c(cccc2)c2cc(O)c1)=O BOYBAZKNDIQEJS-HSZRJFAPSA-N 0.000 description 1
- NVZQGNDUNSRMAU-QHCPKHFHSA-N CCN1[C@H](COc2nc(CN(CC3)c4cc(O)cc5ccccc45)c3c(N(CC3)CCN3C(C=C)=O)n2)CCC1 Chemical compound CCN1[C@H](COc2nc(CN(CC3)c4cc(O)cc5ccccc45)c3c(N(CC3)CCN3C(C=C)=O)n2)CCC1 NVZQGNDUNSRMAU-QHCPKHFHSA-N 0.000 description 1
- TVEZVISYWPBRGO-QHCPKHFHSA-N CN1[C@H](COc2nc(CN(CC3)c4cc(O)cc5ccccc45)c3c(N(CC3)CCN3C(C=C)=O)n2)CCCC1 Chemical compound CN1[C@H](COc2nc(CN(CC3)c4cc(O)cc5ccccc45)c3c(N(CC3)CCN3C(C=C)=O)n2)CCCC1 TVEZVISYWPBRGO-QHCPKHFHSA-N 0.000 description 1
- LTVKHYYCQYQXDM-JTHBVZDNSA-N C[C@@H](CN(CC1)C(C=C)=O)N1c1nc(OC[C@@H]2N(C)CCC2)nc(C2)c1CCN2c1cc(O)cc2c1cccc2 Chemical compound C[C@@H](CN(CC1)C(C=C)=O)N1c1nc(OC[C@@H]2N(C)CCC2)nc(C2)c1CCN2c1cc(O)cc2c1cccc2 LTVKHYYCQYQXDM-JTHBVZDNSA-N 0.000 description 1
- LTVKHYYCQYQXDM-GMAHTHKFSA-N C[C@@H](CN(CC1)C(C=C)=O)N1c1nc(OC[C@H]2N(C)CCC2)nc(C2)c1CCN2c1cc(O)cc2ccccc12 Chemical compound C[C@@H](CN(CC1)C(C=C)=O)N1c1nc(OC[C@H]2N(C)CCC2)nc(C2)c1CCN2c1cc(O)cc2ccccc12 LTVKHYYCQYQXDM-GMAHTHKFSA-N 0.000 description 1
- AHPZXMFMSWWAIG-GAMFZURASA-N C[C@H](CN(CC1)c2nc(OC[C@H]3N(C)CCC3)nc(C3)c2CCN3c2cc(C3CN(C)[C@H](COc4nc(CN(CC5)c6c(cccc7)c7c(C7CN(C)[C@H](COc8nc(N(CC9)CCN9C(/C=C/CN(C)C)=O)c(CCN(C9)c%10c(cccc%11)c%11cc(O)c%10)c9n8)C7)cc6)c5c(N(CC5)CCN5C(C=C)=O)n4)C3)cc3c2cccc3)N1C(C=C)=O Chemical compound C[C@H](CN(CC1)c2nc(OC[C@H]3N(C)CCC3)nc(C3)c2CCN3c2cc(C3CN(C)[C@H](COc4nc(CN(CC5)c6c(cccc7)c7c(C7CN(C)[C@H](COc8nc(N(CC9)CCN9C(/C=C/CN(C)C)=O)c(CCN(C9)c%10c(cccc%11)c%11cc(O)c%10)c9n8)C7)cc6)c5c(N(CC5)CCN5C(C=C)=O)n4)C3)cc3c2cccc3)N1C(C=C)=O AHPZXMFMSWWAIG-GAMFZURASA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662338116P | 2016-05-18 | 2016-05-18 | |
| US62/338,116 | 2016-05-18 | ||
| US201762444614P | 2017-01-10 | 2017-01-10 | |
| US62/444,614 | 2017-01-10 | ||
| PCT/US2017/033099 WO2017201161A1 (en) | 2016-05-18 | 2017-05-17 | Kras g12c inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2017266911A1 AU2017266911A1 (en) | 2018-12-06 |
| AU2017266911B2 true AU2017266911B2 (en) | 2021-09-02 |
Family
ID=60326411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017266911A Active AU2017266911B2 (en) | 2016-05-18 | 2017-05-17 | KRas G12C inhibitors |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11267812B2 (enExample) |
| EP (1) | EP3458445B1 (enExample) |
| JP (1) | JP7039489B2 (enExample) |
| KR (1) | KR102444509B1 (enExample) |
| CN (1) | CN109843856B (enExample) |
| AU (1) | AU2017266911B2 (enExample) |
| CA (1) | CA3024523A1 (enExample) |
| ES (1) | ES2863873T3 (enExample) |
| IL (1) | IL262867B (enExample) |
| MX (1) | MX382339B (enExample) |
| SG (1) | SG11201810171SA (enExample) |
| WO (1) | WO2017201161A1 (enExample) |
Families Citing this family (200)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102444509B1 (ko) | 2016-05-18 | 2022-09-19 | 미라티 테라퓨틱스, 인크. | Kras g12c 억제제 |
| EP3558955B1 (en) | 2016-12-22 | 2021-08-11 | Amgen Inc. | Benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer |
| JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
| EP3679040B1 (en) | 2017-09-08 | 2022-08-03 | Amgen Inc. | Inhibitors of kras g12c and methods of using the same |
| US10647715B2 (en) | 2017-11-15 | 2020-05-12 | Mirati Therapeutics, Inc. | KRas G12C inhibitors |
| EA202091186A1 (ru) * | 2017-11-15 | 2020-10-01 | Мирати Терапьютикс, Инк. | ИНГИБИТОРЫ KRas G12C |
| US10597405B2 (en) | 2017-12-08 | 2020-03-24 | Astrazeneca Ab | Chemical compounds |
| CN113121530B (zh) * | 2018-01-19 | 2022-08-05 | 勤浩医药（苏州）有限公司 | 作为krasg12c突变蛋白抑制剂的吡啶酮并嘧啶类衍生物 |
| TW201942115A (zh) * | 2018-02-01 | 2019-11-01 | 美商輝瑞股份有限公司 | 作為抗癌藥之經取代的喹唑啉和吡啶並嘧啶衍生物 |
| TW201942116A (zh) | 2018-02-09 | 2019-11-01 | 美商輝瑞股份有限公司 | 作為抗癌劑之四氫喹唑啉衍生物 |
| JP7720698B2 (ja) * | 2018-04-04 | 2025-08-08 | アルビナス・オペレーションズ・インコーポレイテッド | タンパク質分解の調節因子および関連する使用方法 |
| AU2019262589B2 (en) * | 2018-05-04 | 2022-07-07 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| ES2995514T3 (en) | 2018-05-04 | 2025-02-10 | Amgen Inc | Kras g12c inhibitors and methods of using the same |
| US11932633B2 (en) | 2018-05-07 | 2024-03-19 | Mirati Therapeutics, Inc. | KRas G12C inhibitors |
| TW202012415A (zh) | 2018-05-08 | 2020-04-01 | 瑞典商阿斯特捷利康公司 | 化學化合物 |
| MX2020011907A (es) | 2018-05-10 | 2021-01-29 | Amgen Inc | Inhibidores de kras g12c para el tratamiento de cancer. |
| ES2938987T3 (es) * | 2018-06-01 | 2023-04-18 | Amgen Inc | Inhibidores de KRAS G12c y métodos de uso de los mismos |
| CA3100390A1 (en) * | 2018-06-12 | 2020-03-12 | Amgen Inc. | Kras g12c inhibitors encompassing piperazine ring and use thereof in the treatment of cancer |
| MX2021001706A (es) | 2018-08-16 | 2021-04-19 | Hoffmann La Roche | Compuestos de anillo fusionado. |
| ES2961253T3 (es) | 2018-08-31 | 2024-03-11 | Mirati Therapeutics Inc | Inhibidores de KRas G12C |
| JP2022500385A (ja) * | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス， インコーポレイテッド | 組み合わせ療法 |
| EP4552631A3 (en) * | 2018-09-10 | 2025-07-02 | Mirati Therapeutics, Inc. | Combination of dasatinib and adagrasib for use in the treatment of non-small cell lung cancer |
| CA3111980A1 (en) * | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| CA3112043A1 (en) * | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| PT3849537T (pt) * | 2018-09-10 | 2025-01-22 | Mirati Therapeutics Inc | Terapêuticas de combinação |
| AU2019344897B2 (en) | 2018-09-18 | 2024-01-18 | Nikang Therapeutics, Inc. | Tri-substituted heteroaryl derivatives AS SRC homology-2 phosphatase inhibitors |
| CN112004802B (zh) | 2018-09-30 | 2021-12-28 | 凯瑞康宁生物工程（武汉）有限公司 | 作为神经元组胺受体-3拮抗剂的化合物及其用途 |
| WO2020085493A1 (ja) | 2018-10-26 | 2020-04-30 | 大鵬薬品工業株式会社 | 新規なインダゾール化合物又はその塩 |
| US11236068B2 (en) * | 2018-11-09 | 2022-02-01 | Genentech, Inc. | Fused ring compounds |
| JP7516029B2 (ja) | 2018-11-16 | 2024-07-16 | アムジエン・インコーポレーテツド | Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法 |
| WO2020106640A1 (en) | 2018-11-19 | 2020-05-28 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法 |
| CA3112129A1 (en) * | 2018-12-05 | 2020-06-11 | Mirati Therapeutics, Inc. | Combination therapies |
| EP3908283A4 (en) | 2019-01-10 | 2022-10-12 | Mirati Therapeutics, Inc. | KRAS G12C INHIBITORS |
| CN113382774A (zh) | 2019-02-12 | 2021-09-10 | 诺华股份有限公司 | 包含tno155和krasg12c抑制剂的药物组合 |
| EP3935060B1 (en) | 2019-03-05 | 2023-11-15 | Astrazeneca AB | Fused tricyclic compounds useful as anticancer agents |
| EP3738593A1 (en) | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
| AU2020279253A1 (en) * | 2019-05-20 | 2021-12-16 | 1200 Pharma Llc | KRAS G12C inhibitors and uses thereof |
| EP3972963A1 (en) | 2019-05-21 | 2022-03-30 | Bayer Aktiengesellschaft | Identification and use of kras inhibitors |
| US12252486B2 (en) | 2019-05-21 | 2025-03-18 | Amgen Inc. | Solid state forms |
| PH12021552922A1 (en) | 2019-05-21 | 2022-04-04 | Amgen Inc | Solid state forms |
| WO2020238791A1 (zh) * | 2019-05-24 | 2020-12-03 | 江苏恒瑞医药股份有限公司 | 氢化吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用 |
| JP7584451B2 (ja) * | 2019-05-29 | 2024-11-15 | 上▲海▼翰森生物医▲薬▼科技有限公司 | 窒素含有複素環系誘導物レギュレーター、その製造方法及び使用 |
| CN112047939B (zh) * | 2019-06-06 | 2023-05-02 | 江苏先声药业有限公司 | 一种具有抗肿瘤活性的四氢吡啶并嘧啶类化合物 |
| CN114040914B (zh) * | 2019-07-01 | 2024-10-22 | 江苏恒瑞医药股份有限公司 | 喹唑啉酮类衍生物、其制备方法及其在医药上的应用 |
| CN112300153B (zh) * | 2019-07-26 | 2023-06-13 | 博瑞生物医药（苏州）股份有限公司 | 一种杂环化合物、药物组合物和用途 |
| CN112390788A (zh) * | 2019-08-13 | 2021-02-23 | 苏州闻天医药科技有限公司 | 一种用于抑制krasg12c突变蛋白的化合物及其制备方法和用途 |
| CN112390797A (zh) * | 2019-08-15 | 2021-02-23 | 微境生物医药科技(上海)有限公司 | 新型螺环类K-Ras G12C抑制剂 |
| CN112390796B (zh) * | 2019-08-19 | 2023-06-27 | 贝达药业股份有限公司 | Kras g12c抑制剂及其在医药上的应用 |
| CN112430234B (zh) * | 2019-08-26 | 2023-04-28 | 信达生物制药(苏州)有限公司 | 一种新型kras g12c蛋白抑制剂及其制备方法和用途 |
| KR20220071193A (ko) * | 2019-08-29 | 2022-05-31 | 미라티 테라퓨틱스, 인크. | Kras g12d 억제제 |
| WO2021043322A1 (zh) * | 2019-09-06 | 2021-03-11 | 正大天晴药业集团南京顺欣制药有限公司 | 氮杂环庚烷并嘧啶类衍生物及其医药用途 |
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