IL152669A0 - Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 - Google Patents

Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

Info

Publication number
IL152669A0
IL152669A0 IL15266901A IL15266901A IL152669A0 IL 152669 A0 IL152669 A0 IL 152669A0 IL 15266901 A IL15266901 A IL 15266901A IL 15266901 A IL15266901 A IL 15266901A IL 152669 A0 IL152669 A0 IL 152669A0
Authority
IL
Israel
Prior art keywords
inhibitors
beta
dehydrogenase type
steroid dehydrogenase
hydroxy steroid
Prior art date
Application number
IL15266901A
Other languages
English (en)
Original Assignee
Biovitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovitrum Ab filed Critical Biovitrum Ab
Publication of IL152669A0 publication Critical patent/IL152669A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/84—Naphthothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL15266901A 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 IL152669A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0001899A SE0001899D0 (sv) 2000-05-22 2000-05-22 New compounds
PCT/SE2001/001155 WO2001090090A1 (fr) 2000-05-22 2001-05-22 Inhibiteurs de 11-beta-hydroxy-steroide-deshydrogenase de type 1

Publications (1)

Publication Number Publication Date
IL152669A0 true IL152669A0 (en) 2003-06-24

Family

ID=20279781

Family Applications (4)

Application Number Title Priority Date Filing Date
IL15266901A IL152669A0 (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
IL15267001A IL152670A0 (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
IL15275301A IL152753A0 (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
IL15279001A IL152790A0 (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL15267001A IL152670A0 (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
IL15275301A IL152753A0 (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
IL15279001A IL152790A0 (en) 2000-05-22 2001-05-22 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

Country Status (24)

Country Link
US (7) US7125900B2 (fr)
EP (4) EP1283831A1 (fr)
JP (4) JP2003534337A (fr)
KR (4) KR20030016272A (fr)
CN (4) CN1430614A (fr)
AR (1) AR033534A1 (fr)
AT (2) ATE485283T1 (fr)
AU (6) AU6093101A (fr)
BR (1) BR0111099A (fr)
CA (4) CA2408783A1 (fr)
DE (3) DE60143293D1 (fr)
EA (1) EA005274B1 (fr)
ES (1) ES2333846T3 (fr)
HK (1) HK1056878A1 (fr)
HU (1) HUP0302435A3 (fr)
IL (4) IL152669A0 (fr)
MX (1) MXPA02011632A (fr)
NO (4) NO323831B1 (fr)
NZ (4) NZ522507A (fr)
PE (1) PE20020100A1 (fr)
PL (1) PL360137A1 (fr)
SE (1) SE0001899D0 (fr)
WO (5) WO2001090092A1 (fr)
ZA (4) ZA200209360B (fr)

Families Citing this family (185)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0001899D0 (sv) 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
AU2001276378A1 (en) * 2000-07-05 2002-01-14 Bayer Aktiengesellschaft Regulation of human 11 beta-hydroxysteroid dehydrogenase 1-like enzyme
GB0107383D0 (en) * 2001-03-23 2001-05-16 Univ Edinburgh Lipid profile modulation
MXPA04004779A (es) * 2001-11-22 2004-07-30 Biovitrum Ab Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa de tipo 1.
EA200400709A1 (ru) * 2001-11-22 2004-12-30 Биовитрум Аб Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
US7074788B2 (en) * 2001-11-22 2006-07-11 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
EP1461327A1 (fr) * 2001-11-22 2004-09-29 Biovitrum Ab Inhibiteurs de la 11-beta-hydroxysteroide deshydrogenase de type 1
EA200400707A1 (ru) * 2001-11-22 2004-10-28 Биовитрум Аб Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
AU2007205749B2 (en) * 2001-11-22 2009-04-23 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
WO2003061655A1 (fr) 2002-01-16 2003-07-31 University Of Virginia Patent Foundation Activateurs allosteriques 2-aminothiazoles des recepteurs de l'adenosine a1
CA2474168A1 (fr) * 2002-02-01 2003-08-14 Merck & Co., Inc. Inhibiteurs de la 11-beta-hydroxysteroide deshydrogenase 1 utiles pour le traitement du diabete, de l'obesite et de la dyslipidemie
US7338969B2 (en) * 2002-03-08 2008-03-04 Quonova, Llc Modulation of pathogenicity
CA2480481A1 (fr) * 2002-03-29 2003-10-16 Schering Corporation Alkylation stereoselective de piperazines 2-methyl-4-protegees chirales
SE0201194D0 (sv) * 2002-04-19 2002-04-19 Astrazeneca Ab New compounds
US20030198965A1 (en) 2002-04-19 2003-10-23 Isis Pharmaceuticals Inc. Antisense modulation of hydroxysteroid 11-beta dehydrogenase 1 expression
AR040241A1 (es) * 2002-06-10 2005-03-23 Merck & Co Inc Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
US20040138258A1 (en) * 2002-09-18 2004-07-15 Hanauske-Abel Hartmut M. Inhibitors of 11beta-hydroxysteroid dehydrogenase and uses therefor
MXPA05003632A (es) * 2002-10-11 2005-06-03 Astrazeneca Ab Derivados de piperidina 1, 4-disustituidos y su uso como inhibidores de 11-beta-hidroesteroide deshidrogenasa humana de tipo 1 (11betahsd1).
KR20050059294A (ko) * 2002-10-24 2005-06-17 스테릭스 리미티드 11-베타-하이드록시 스테로이드 데하이드로게나제 형태 1및 형태 2의 억제제
GB0224830D0 (en) 2002-10-24 2002-12-04 Sterix Ltd Compound
US20060058315A1 (en) * 2002-11-07 2006-03-16 Astrazeneca Ab 2-Oxo-ethanesulfonamide derivates
GB0226602D0 (en) * 2002-11-14 2002-12-24 Novartis Ag Organic compounds
AR041952A1 (es) * 2002-11-14 2005-06-01 Novartis Ag N-sulfonilaminotiazol
JO2397B1 (en) * 2002-12-20 2007-06-17 ميرك شارب اند دوم كوربوريشن Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
WO2004056744A1 (fr) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides utilises comme inhibiteurs de la hydroxysteroide deshydrogenase
FR2849598B1 (fr) * 2003-01-07 2006-09-22 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans
FR2849599B1 (fr) * 2003-01-07 2006-12-29 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete
TW200503994A (en) * 2003-01-24 2005-02-01 Novartis Ag Organic compounds
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DE10314610A1 (de) 2003-04-01 2004-11-04 Aventis Pharma Deutschland Gmbh Neues Diphenylazetidinon mit verbesserten physiologischen Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindungen enthaltende Arzneimittel und dessen Verwendung
US7700583B2 (en) 2003-04-11 2010-04-20 High Point Pharmaceuticals, Llc 11β-hydroxysteroid dehydrogenase type 1 active compounds
US7501405B2 (en) 2003-04-11 2009-03-10 High Point Pharmaceuticals, Llc Combination therapy using an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders
EP1787982B1 (fr) * 2003-04-11 2010-05-12 High Point Pharmaceuticals, LLC Composés ayant une activité sur la 11beta-hydroxysteroid dehydrogenase
EP1785424A3 (fr) * 2003-04-11 2009-12-23 High Point Pharmaceuticals, LLC 1,2,4 triazoles condensés et leurs utilisations pharmacéutiques
EP1615647B1 (fr) * 2003-04-11 2010-01-20 High Point Pharmaceuticals, LLC Utilisation pharmaceutique de 1,2,4-triazoles fusionnes
US7173030B2 (en) 2003-05-21 2007-02-06 Biovitrum Ab Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
EP1631558A1 (fr) * 2003-05-21 2006-03-08 Biovitrum Ab Inhibiteurs de 11-beta-hydroxy steroide deshydrogenase de type i
JP4499106B2 (ja) 2003-05-29 2010-07-07 メルク・シャープ・エンド・ドーム・コーポレイション １１−ベータ−水酸化ステロイド脱水素酵素−１の阻害剤としてのトリアゾール誘導体
SE0301882D0 (sv) * 2003-06-25 2003-06-25 Biovitrum Ab New use I
SE0301884D0 (sv) * 2003-06-25 2003-06-25 Biovitrum Ab New use III
SE0301883D0 (sv) * 2003-06-25 2003-06-25 Biovitrum Ab New use II
WO2004113310A1 (fr) * 2003-06-25 2004-12-29 Biovitrum Ab Utilisation d'un inhibiteur de compose de type 1 11-b-hydroxysteroide deshydrogenase type 1 destine a faciliter la cicatrisation d'une plaie
SE0301885D0 (sv) * 2003-06-25 2003-06-25 Biovitrum Ab New use IV
CN1902177A (zh) 2003-09-22 2007-01-24 万有制药株式会社 新哌啶衍生物
GB0324792D0 (en) 2003-10-23 2003-11-26 Sterix Ltd Compound
GB0325745D0 (en) * 2003-11-05 2003-12-10 Astrazeneca Ab Chemical compounds
EP1696915A1 (fr) * 2003-12-19 2006-09-06 Pfizer, Inc. Derives de benzenesulfonylamino-pyridin-2yl et composes apparentes en tant qu'inhibiteurs de la 11-beta-hydeoxysteroide deshydrogenase type 1 (11-beta-hsd-1) pour le traitement du diabete et de l'obesite
WO2005063247A1 (fr) 2003-12-22 2005-07-14 Amgen Inc. Composes de sulfonamide d'aryle et procedes d'utilisation correspondants
EP1711477A4 (fr) 2004-01-26 2009-06-10 Merck & Co Inc Nouvelles formes cristallines d'un inhibiteur de la 11-beta-hydroxysteroide dehydrogenase de type 1
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
JP2007261945A (ja) * 2004-04-07 2007-10-11 Taisho Pharmaceut Co Ltd チアゾール誘導体
WO2005110980A2 (fr) * 2004-04-14 2005-11-24 Amgen, Inc. Sulfones d'aryle et utilisations liées à eux
ES2390057T3 (es) * 2004-04-20 2012-11-06 Amgen Inc. Arilsulfonilamidas y usos como hidroxiesteroide deshidrogenasa
GB0408771D0 (en) * 2004-04-20 2004-05-26 Sterix Ltd Compound
CN101001836B (zh) 2004-05-07 2010-12-22 詹森药业有限公司 作为11-β羟基类固醇脱氢酶抑制剂的吡咯烷-2-酮和哌啶-2-酮衍生物
US8686011B2 (en) 2004-05-24 2014-04-01 Amgen Inc. Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
AR049344A1 (es) 2004-05-24 2006-07-19 Amgen Inc Inhibidores de la 11-beta-hidroxi esteroide deshidrogenasa de tipo 1
JP4809339B2 (ja) 2004-06-28 2011-11-09 エフ．ホフマン−ラ ロシュ アーゲー ピリミジン誘導体
EP1791822A1 (fr) * 2004-08-05 2007-06-06 F.Hoffmann-La Roche Ag Aminothiazoles substitués n-acyle-2-
ES2334246T3 (es) 2004-08-30 2010-03-08 Janssen Pharmaceutica Nv Derivados triciclos de adamantilamida como inhibidores de la 11-beta-hidroxiesteroide-deshidrogenasa.
DE602005017159D1 (de) 2004-08-30 2009-11-26 Janssen Pharmaceutica Nv Oxysteroid-dehydrogenase-inhibitoren
BRPI0515121A (pt) 2004-08-30 2008-07-08 Janssen Pharmaceutica Nv derivados da n-2 adamantil-2-fenóxi acetamida como inibidores da 11-beta hidroxiesteróide desidrogenase
CN101027286B (zh) * 2004-09-29 2011-05-25 霍夫曼-拉罗奇有限公司 作为11b-HSD1抑制剂的吲唑酮衍生物
NZ554014A (en) * 2004-10-04 2010-06-25 Hoffmann La Roche Alkil-pyridines as 11-beta inhibitors for diabetes
ES2436178T3 (es) * 2004-10-14 2013-12-27 Abbvie Deutschland Gmbh & Co Kg Compuestos aromáticos sustituidos con arilsulfonilmetilo o arilsulfonamida adecuados para tratar trastornos que responden a la modulación del receptor de dopamina D3
CA2580690A1 (fr) 2004-10-21 2006-05-04 Transtech Pharma, Inc. Composes bissulfonamide utilises en tant qu'agonistes du galr1, compositions, et procedes d'utilisation associes
EP1659113A1 (fr) * 2004-11-08 2006-05-24 Evotec AG Inhibiteurs de 11 beta hydroxy stéroid dehydrogenase type 1 (11beta-HSD1)
EP1666467A1 (fr) * 2004-11-08 2006-06-07 Evotec AG Inhibiteurs de 11-béta-HSD1
WO2006051662A1 (fr) * 2004-11-09 2006-05-18 Taisho Pharmaceutical Co., Ltd. Derive de thiazole
WO2006059507A1 (fr) * 2004-11-30 2006-06-08 Sankyo Company, Limited Compose antisens 11?-hsd1
EP1888544A2 (fr) * 2004-12-17 2008-02-20 Takeda San Diego, Inc. Inhibiteurs des hydroxystéroides déshydrogénases
GB0506133D0 (en) * 2005-03-24 2005-05-04 Sterix Ltd Compound
EP1866298A2 (fr) 2005-03-31 2007-12-19 Takeda San Diego, Inc. Inhibiteurs de l'hydroxysteroide deshydrogenase
DK1928840T3 (da) 2005-04-05 2011-09-12 Hoffmann La Roche 1H-pyrazol-4-carboxamider, deres fremstilling og deres anvendelse som 11-beta-hydroxysteroid-dehydrogenaseinhibitorer
ES2574014T3 (es) 2005-05-30 2016-06-14 Msd K.K. Derivado de piperidina novedoso
WO2006134481A1 (fr) * 2005-06-16 2006-12-21 Pfizer Inc. Inhibiteurs de la 11-beta hydroxysteroide deshydrogenase de type 1
ES2334518T3 (es) * 2005-06-16 2010-03-11 Pfizer, Inc. Derivados de n-(piridin-2-il)-sulfonamida.
AU2006277253A1 (en) 2005-08-10 2007-02-15 Msd K.K. Pyridone compound
CA2619770A1 (fr) 2005-08-24 2007-03-01 Banyu Pharmaceutical Co., Ltd. Derive phenylpyridone
US7622492B2 (en) 2005-08-31 2009-11-24 Hoffmann-La Roche Inc. Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
CA2621470A1 (fr) 2005-09-07 2007-03-15 Banyu Pharmaceutical Co., Ltd. Derive de pyridone substitue aromatique bicylique
US8293900B2 (en) 2005-09-29 2012-10-23 Merck Sharp & Dohme Corp Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
JP2007099659A (ja) * 2005-10-03 2007-04-19 Toray Fine Chemicals Co Ltd ピペラジンカルボン酸エステルの製造法
EP1934191B1 (fr) * 2005-10-12 2012-03-28 Vertex Pharmaceuticals, Inc. Derives de biphenyle utilises comme modulateurs des canaux ioniques sensibles au voltage
RU2008119687A (ru) 2005-10-21 2009-11-27 Новартис АГ (CH) Комбинации органических соединений
CA2627139A1 (fr) 2005-10-27 2007-05-03 Banyu Pharmaceutical Co., Ltd. Nouveau derive de benzoxathiine
WO2007055418A1 (fr) 2005-11-10 2007-05-18 Banyu Pharmaceutical Co., Ltd. Derive spiro aza-substitue
US20070110802A1 (en) * 2005-11-15 2007-05-17 Janan Jona Wet granulation process
CA2630718A1 (fr) 2005-11-22 2007-05-31 Amgen Inc. Inhibiteurs de la 11-beta-hydroxy steroide deshydrogenase de type 1
RU2008129821A (ru) 2005-12-21 2010-01-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Гетероциклические производные в качестве модуляторов ионных каналов
EP1976495A2 (fr) * 2006-01-06 2008-10-08 Aarhus Universitet Composes agissant sur le transporteur de la serotonine
CA2636826C (fr) 2006-01-18 2011-11-29 F.Hoffmann-La Roche Ag Thiazoles en tant qu'inhibiteurs de 11 beta-hsd1
PL2029529T3 (pl) * 2006-04-24 2010-11-30 Lilly Co Eli PODSTAWIONE PIROLIDYNONY JAKO INHIBITORY DEHYDROGENAZY 11-ß-HYDROKSYSTEROIDOWEJ TYPU 1
AU2007244971B2 (en) * 2006-04-24 2012-01-19 Eli Lilly And Company Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
CN101096363B (zh) * 2006-06-27 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途
AU2007283113A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
EP2946778A1 (fr) 2006-09-22 2015-11-25 Merck Sharp & Dohme Corp. Procédé de traitement utilisant des inhibiteurs de la synthèse d'acides gras
EP2072519A4 (fr) 2006-09-28 2009-10-21 Banyu Pharma Co Ltd Dérivé de diarylcétimine
DE102007005045B4 (de) 2007-01-26 2008-12-18 Sanofi-Aventis Phenothiazin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CN101668524B (zh) * 2007-02-12 2012-10-24 阿斯利康(瑞典)有限公司 作为11-β-HSD1抑制剂的吡唑衍生物
EP2125704A1 (fr) 2007-02-23 2009-12-02 High Point Pharmaceuticals, LLC N-adamantyl benzamides utilisés en tant qu'inhibiteurs de la 11-bêta-hydroxystéroïde déshydrogénase
EP2146952A1 (fr) 2007-02-23 2010-01-27 High Point Pharmaceuticals, LLC N-adamantylbenzamides utiles comme inhibiteurs de 11-beta-hydroxysteroide deshydrogenase
AU2008219326B2 (en) 2007-02-23 2012-12-13 Vtv Therapeutics Llc N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
CL2008000835A1 (es) 2007-03-23 2008-10-03 Icagen Inc Pfizer Ltd Compuestos derivados de sulfonamidas, inhibidores de los canales de calcio; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del dolor, sindrome de intestino irritable, enfermedad de crohn, taquiarritm
JP5319518B2 (ja) 2007-04-02 2013-10-16 Ｍｓｄ株式会社 インドールジオン誘導体
JP2010523692A (ja) * 2007-04-11 2010-07-15 ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー 新規合成物
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2170930B3 (fr) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
US8222417B2 (en) 2007-06-27 2012-07-17 Taisho Pharmaceutical Co., Ltd Compound having 11β-HSD1 inhibitory activity
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
DE102007054497B3 (de) 2007-11-13 2009-07-23 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung
WO2009110510A1 (fr) 2008-03-06 2009-09-11 萬有製薬株式会社 Dérivé d'alkylaminopyridine
EP2272841A1 (fr) 2008-03-28 2011-01-12 Banyu Pharmaceutical Co., Ltd. Dérivé de diarylméthylamide à activité antagoniste sur un récepteur d'hormone concentrant la mélanine
EP2328910B1 (fr) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
CA2727914A1 (fr) 2008-06-19 2009-12-23 Banyu Pharmaceutical Co., Ltd. Derive de spirodiamine-diarylcetoxime
WO2010003624A2 (fr) 2008-07-09 2010-01-14 Sanofi-Aventis Composés hétérocycliques, leurs procédés de préparation, médicaments comprenant lesdits composés et leur utilisation
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
AU2009277736A1 (en) 2008-07-30 2010-02-04 Banyu Pharmaceutical Co., Ltd. (5-membered)-(5-membered) or (5-membered)-(6-membered) fused ring cycloalkylamine derivative
WO2010047982A1 (fr) 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Nouveaux dérivés de benzimidazole cycliques utiles comme agents anti-diabétiques
US8592457B2 (en) 2008-10-30 2013-11-26 Merck Sharp & Dohme Corp. Isonicotinamide orexin receptor antagonists
US8329914B2 (en) 2008-10-31 2012-12-11 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
KR200452117Y1 (ko) * 2008-11-10 2011-02-08 대성공업주식회사 휠체어용 브레이크 와이어 케이블 지지 브래킷
EA020496B1 (ru) 2008-11-21 2014-11-28 ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Производное адамантилбензамида, фармацевтическая композиция, включающая его, и его применение
WO2010068601A1 (fr) 2008-12-08 2010-06-17 Sanofi-Aventis Hydrate de fluoroglycoside hétéroaromatique cristallin, ses procédés de fabrication, ses procédés d'utilisation et compositions pharmaceutiques le contenant
ES2350077B1 (es) 2009-06-04 2011-11-04 Laboratorios Salvat, S.A. Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1.
CN102482312A (zh) 2009-08-26 2012-05-30 赛诺菲 新颖的杂芳族氟代糖苷结晶水合物、含有这些化合物的药物和它们的用途
CA2786314A1 (fr) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Nouveaux derives benzimidazole cycliques utiles comme agents antidiabetiques
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
US8513430B2 (en) 2010-07-27 2013-08-20 High Point Pharmaceuticals, Llc Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta HSD1 modulators
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2677869B1 (fr) 2011-02-25 2017-11-08 Merck Sharp & Dohme Corp. Nouveaux dérivés d'azabenzimidazole cyclique utiles en tant qu'agents antidiabétiques
KR102034748B1 (ko) 2011-03-01 2019-10-21 시너지 파마슈티컬즈 인코포레이티드 구아닐레이트 사이클라제 c 작용제의 제조 방법
WO2012120054A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
EP2683704B1 (fr) 2011-03-08 2014-12-17 Sanofi Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation
EP2683699B1 (fr) 2011-03-08 2015-06-24 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120058A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés d'oxathiazine substitués par des groupes benzyle ou hétérométhylène, leur procédé de production, leur utilisation comme médicament ainsi que produits pharmaceutiques les contenant et leur utilisation
EP2683703B1 (fr) 2011-03-08 2015-05-27 Sanofi Nouveaux dérivés phényl-oxathiazine substitués, procédé pour leur préparation, agent pharmaceutique contenant ces composés et leur utilisation
WO2012120050A1 (fr) 2011-03-08 2012-09-13 Sanofi Nouveaux dérivés phényl-oxathiazine substitués, procédé pour leur préparation, médicaments contenant ces composés et leur utilisation
WO2012120052A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
WO2012120056A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120051A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés benzyl-oxathiazine substitués avec adamantane ou noradamantane, médicaments contenant ces composés et leur utilisation
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
EP2567959B1 (fr) 2011-09-12 2014-04-16 Sanofi Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013045413A1 (fr) 2011-09-27 2013-04-04 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
CN103204824B (zh) * 2012-01-12 2015-04-08 清华大学深圳研究生院 2-氨基噻唑-4-酰胺类衍生物及其制备方法与应用
RU2015106909A (ru) 2012-08-02 2016-09-27 Мерк Шарп И Доум Корп. Антидиабетические трициклические соединения
CA2898482A1 (fr) 2013-02-22 2014-08-28 Linda L. Brockunier Composes bicycliques antidiabetiques
US9650375B2 (en) 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
TW201512171A (zh) 2013-04-19 2015-04-01 Pfizer Ltd 化學化合物
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
WO2015051496A1 (fr) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Composés tricycliques antidiabétiques
RU2021109549A (ru) 2014-08-29 2021-05-13 Тес Фарма С.Р.Л. ИНГИБИТОРЫ α-АМИНО-β-КАРБОКСИМУКОНАТ ε-СЕМИАЛЬДЕГИД-ДЕКАРБОКСИЛАЗЫ
CN105001152A (zh) * 2015-07-19 2015-10-28 佛山市赛维斯医药科技有限公司 一类二甲胺基二吡啶叔醇结构的11β-HSD1抑制剂及其用途
CN105017135A (zh) * 2015-07-19 2015-11-04 佛山市赛维斯医药科技有限公司 一类二吡啶叔醇结构的11β-HSD1抑制剂、制备方法及其用途
EP3235813A1 (fr) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Dérivés aza-tétra-cycliques
BR112019007543A2 (pt) 2016-10-14 2019-07-02 Tes Pharma S R L inibidores de ácido alfa-amino-beta-carboximuconico semialdeido decarboxilase
CN107663204A (zh) * 2016-10-19 2018-02-06 首都医科大学附属北京世纪坛医院 一种化合物的抗结核应用
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
EP3558298A4 (fr) 2016-12-20 2020-08-05 Merck Sharp & Dohme Corp. Composés de spirochromane antidiabétiques
EP3717465A1 (fr) 2017-11-30 2020-10-07 Step Pharma S.A.S. Composés
WO2019106156A1 (fr) * 2017-11-30 2019-06-06 Step Pharma S.A.S. Composés
MD3752510T2 (ro) 2018-02-15 2023-06-30 Vertex Pharma Macrociclii ca modulatori ai regulatorului conductanței transmembranare în fibroza chistică, compoziții farmaceutice ale acestora, utilizarea lor în tratamentul fibrozei chistice, și procedeu pentru fabricarea acestora
CN108358869B (zh) * 2018-03-27 2019-09-10 河北师范大学 一种n-苯并噻唑基苯磺酰胺类衍生物、制备方法及用途
CN108659219B (zh) * 2018-06-08 2021-02-09 扬州大学 一种聚苯胺的制备方法
AR117122A1 (es) 2018-11-20 2021-07-14 Tes Pharma S R L INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
CN109748831A (zh) * 2018-12-17 2019-05-14 南通正达农化有限公司 一种三氟甲磺酸三氟乙酯的制备方法
EP3924058A1 (fr) 2019-02-13 2021-12-22 Merck Sharp & Dohme Corp. Agonistes du récepteur de l'orexine 5-alkyl-pyrrolidine
EP4010314B1 (fr) 2019-08-08 2024-02-28 Merck Sharp & Dohme LLC Agonistes du récepteur de l'orexine de type pyrrolidine et pipéridine hétéroaryle
CN114599657A (zh) 2019-08-14 2022-06-07 弗特克斯药品有限公司 Cftr调节剂的结晶形式
TW202120517A (zh) 2019-08-14 2021-06-01 美商維泰克斯製藥公司 製備cftr調節劑之方法
TW202115092A (zh) 2019-08-14 2021-04-16 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白之調節劑
CN111620837B (zh) * 2020-06-29 2022-02-15 郑州大学 香柏酮噻唑酰胺类化合物、及其制备方法和应用
IL300610A (en) 2020-08-18 2023-04-01 Merck Sharp ַ& Dohme Llc Bicycloheptane pyrrolidine compounds are orexin receptor agonists
WO2022076629A1 (fr) * 2020-10-07 2022-04-14 Vertex Pharmaceuticals Incorporated Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique
CN112451514A (zh) * 2020-11-26 2021-03-09 江西农业大学 二氢杨梅素纳米硒及其制备方法和应用
CN113461635A (zh) * 2021-07-07 2021-10-01 上海毕得医药科技股份有限公司 4-（2-氯乙基）噻唑-2-羧酸乙酯及其制备方法和应用
WO2023023310A1 (fr) * 2021-08-20 2023-02-23 Enanta Pharmaceuticals, Inc. Inhibiteurs de la 17-bêta-hydroxystéroïde déshydrogénase de type 13 et leurs procédés d'utilisation

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB517272A (en) * 1938-06-03 1940-01-25 May & Baker Ltd The preparation of new therapeutically useful heterocyclic compounds
GB620654A (en) * 1939-10-03 1949-03-29 Chinoin Gyogyszer Es Vegyeszet A process for the preparation of sulphonamide derivatives of 2-amino-thiazole
US2611770A (en) 1949-04-16 1952-09-23 American Cyanamid Co N-(2-thiazolyl)-2-hydroxypyridine-5-sulfonamides
GB822947A (en) 1957-01-25 1959-11-04 Smith & Nephew Improvements in and relating to sulphonamides
DE1620508A1 (de) 1965-07-23 1969-09-18 Thomae Gmbh Dr K Verfahren zur Herstellung neuer 4,5,6,7-Tetrahydrothiazolo-[5,4-c]-pyridine
CA1088049A (fr) * 1975-06-03 1980-10-21 Takashi Masugi Procedes d'obtention de derives d'acides alcanamido substitues en 3 et substitues en 7-3-cephem-4 carboxyliques
FR2384498A1 (fr) 1975-11-26 1978-10-20 Parcor Nouveaux derives sulfonylamino thiazoliques et leurs applications en medecine humaine et veterinaire
EP0246749A3 (fr) * 1986-05-17 1988-08-31 AgrEvo UK Limited Triazoles herbicides
US5962490A (en) 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5591761A (en) 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5594021A (en) 1993-05-20 1997-01-14 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
JPH021483A (ja) 1988-03-10 1990-01-05 Nippon Tokushu Noyaku Seizo Kk 農業用殺菌剤
JPH078863B2 (ja) 1989-09-21 1995-02-01 久光製薬株式会社 新規なジフェニルチアゾール誘導体
DE69206725T2 (de) * 1991-09-10 1996-05-02 Zeneca Ltd Benzolsulfonamidderivate als 5-Lipoxygenasehemmer
JPH0670024B2 (ja) 1993-04-13 1994-09-07 塩野義製薬株式会社 グルタコン酸エステル誘導体の製法
US6030991A (en) 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
JPH07149746A (ja) * 1993-11-30 1995-06-13 Hisamitsu Pharmaceut Co Inc 新規な２−置換アミノチアゾール誘導体
JPH07149745A (ja) * 1993-11-30 1995-06-13 Hisamitsu Pharmaceut Co Inc 新規な２−アミノチアゾール誘導体
JPH07309757A (ja) * 1994-05-18 1995-11-28 Asahi Chem Ind Co Ltd βアミロイド蛋白神経細胞毒性低減剤
SI0779810T1 (en) 1994-08-09 2003-12-31 Cortendo Ab Use of ketoconazole and related substances in medicaments for treatment of type ii diabetes
US5856347A (en) * 1994-11-29 1999-01-05 Hisamitsu Pharmaceutical Co., Inc. Antibacterial preparation or bactericide comprising 2-aminothiazole derivative and/or salt thereof
SE505391C2 (sv) 1995-05-30 1997-08-18 Cortendo Ab Användning av kortisol-agonister för framställning av ett system för diagnostisering av det metabola syndromet
GB9512697D0 (en) 1995-06-22 1995-08-23 Zeneca Ltd Heterocyclic compounds
GB9517622D0 (en) * 1995-08-29 1995-11-01 Univ Edinburgh Regulation of intracellular glucocorticoid concentrations
WO1997047299A1 (fr) * 1996-06-12 1997-12-18 3-Dimensional Pharmaceuticals, Inc. Inhibiteurs de protease heterocyclique amidino et guanidino
US5877193A (en) 1996-07-19 1999-03-02 Hoffmann-La Roche Inc. Use of N-(4-aryl-thiazol-2-yl)-sulfonamides
KR20000049197A (ko) 1996-10-16 2000-07-25 윌리암 에이취 캘넌, 에곤 이 버그 매트릭스 메탈로프로테이나제 및 종양 괴사 인자-α 전환 효소억제제로서의 오르토-설폰아미도 헤테로아릴 하이드록삼산의 제조 및 용도
DZ2376A1 (fr) 1996-12-19 2002-12-28 Smithkline Beecham Plc Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
SE9700642D0 (sv) 1997-02-24 1997-02-24 Kronvall Stefan Med Ab Medel och sätt för förebyggande och behandling av det metabola syndromet
US5783597A (en) * 1997-03-04 1998-07-21 Ortho Pharmaceutical Corporation 2,5-disubstituted thiophenes: inhibitors of 5-lipoxygenase and inducible cyclooxygenase (COX-2) enzymes, composition and use
AU736256B2 (en) 1997-07-11 2001-07-26 Smithkline Beecham Plc Novel compounds
GB9725141D0 (en) 1997-11-27 1998-01-28 Pharmacia & Upjohn Spa Benzenesulfonamide compounds
AU768751B2 (en) 1998-06-18 2004-01-08 Bristol-Myers Squibb Company Carbon substituted aminothiazole inhibitors of cyclin dependent kinases
HU228111B1 (en) 1998-07-08 2012-11-28 Sanofi Aventis Deutschland Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them
GB9915625D0 (en) 1999-07-02 1999-09-01 Cortendo Ab Method
GB0001449D0 (en) 2000-01-21 2000-03-08 Cortendo Ab Compositions
IT1317735B1 (it) 2000-01-26 2003-07-15 Nicox Sa Sali di agenti antimicrobici.
SE0001899D0 (sv) 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
AU2002213048A1 (en) 2000-10-05 2002-04-15 Smith Kline Beecham Corporation Phosphate transport inhibitors
GB0118300D0 (en) 2001-07-26 2001-09-19 Cortendo Ab Formulations
MXPA04004779A (es) 2001-11-22 2004-07-30 Biovitrum Ab Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa de tipo 1.
EA200400707A1 (ru) * 2001-11-22 2004-10-28 Биовитрум Аб Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
EA200400709A1 (ru) * 2001-11-22 2004-12-30 Биовитрум Аб Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
US7074788B2 (en) * 2001-11-22 2006-07-11 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

Also Published As

Publication number Publication date
AR033534A1 (es) 2003-12-26
ATE443055T1 (de) 2009-10-15
CA2408142C (fr) 2009-10-20
JP2003534337A (ja) 2003-11-18
AU2001262831B2 (en) 2006-12-21
ZA200209362B (en) 2004-02-18
HUP0302435A2 (hu) 2003-12-29
US20060287374A1 (en) 2006-12-21
NO20025587D0 (no) 2002-11-21
CN1430614A (zh) 2003-07-16
CA2408783A1 (fr) 2001-11-29
US20040224996A1 (en) 2004-11-11
US20030199501A1 (en) 2003-10-23
US20100113435A1 (en) 2010-05-06
US7132436B2 (en) 2006-11-07
IL152753A0 (en) 2003-06-24
US20030166689A1 (en) 2003-09-04
AU2001262831B9 (en) 2007-08-09
NO323831B1 (no) 2007-07-09
NO323779B1 (no) 2007-07-02
AU6093201A (en) 2001-12-03
ZA200209364B (en) 2004-02-18
WO2001090091A8 (fr) 2002-07-25
JP2003534339A (ja) 2003-11-18
DE60143293D1 (de) 2010-12-02
KR20030016272A (ko) 2003-02-26
DE1283831T1 (de) 2003-08-14
PL360137A1 (en) 2004-09-06
WO2001090091A1 (fr) 2001-11-29
CA2409697C (fr) 2010-07-13
EA200201271A1 (ru) 2003-04-24
NO20025585D0 (no) 2002-11-21
NZ522506A (en) 2004-08-27
NO20025588L (no) 2002-12-20
KR20030016271A (ko) 2003-02-26
ZA200209360B (en) 2004-02-18
WO2001090093A1 (fr) 2001-11-29
CN1438997A (zh) 2003-08-27
KR20030011341A (ko) 2003-02-07
NO323832B1 (no) 2007-07-09
NZ522538A (en) 2004-09-24
US20060160797A1 (en) 2006-07-20
NZ522507A (en) 2004-11-26
AU6283101A (en) 2001-12-03
JP2003534336A (ja) 2003-11-18
WO2001090092A1 (fr) 2001-11-29
CA2409697A1 (fr) 2001-11-29
AU2001262830A1 (en) 2001-12-03
CN1437588A (zh) 2003-08-20
US20030176476A1 (en) 2003-09-18
EP1283831A1 (fr) 2003-02-19
EP1283834B1 (fr) 2009-09-16
US7618961B2 (en) 2009-11-17
CN1188403C (zh) 2005-02-09
CN1249039C (zh) 2006-04-05
CA2408142A1 (fr) 2001-11-29
DE60139931D1 (de) 2009-10-29
CA2408144A1 (fr) 2001-11-29
BR0111099A (pt) 2003-04-15
PE20020100A1 (es) 2002-02-13
KR20030016269A (ko) 2003-02-26
AU6445601A (en) 2001-12-03
NO20025585L (no) 2002-12-23
EP1283832A1 (fr) 2003-02-19
WO2001090090A1 (fr) 2001-11-29
WO2001090094A1 (fr) 2001-11-29
ZA200209359B (en) 2004-02-18
US7125900B2 (en) 2006-10-24
US7030135B2 (en) 2006-04-18
EP1283832B1 (fr) 2010-10-20
ES2333846T3 (es) 2010-03-02
NZ522591A (en) 2004-09-24
NO20025588D0 (no) 2002-11-21
CN1430615A (zh) 2003-07-16
SE0001899D0 (sv) 2000-05-22
CA2408144C (fr) 2009-11-24
EP1283833A1 (fr) 2003-02-19
MXPA02011632A (es) 2004-05-05
EP1283834A1 (fr) 2003-02-19
NO20025586D0 (no) 2002-11-21
HUP0302435A3 (en) 2007-05-02
HK1056878A1 (en) 2004-03-05
IL152670A0 (en) 2003-06-24
ATE485283T1 (de) 2010-11-15
EA005274B1 (ru) 2004-12-30
IL152790A0 (en) 2003-06-24
NO20025586L (no) 2003-01-21
AU6093101A (en) 2001-12-03
NO20025587L (no) 2003-01-21
JP2003534338A (ja) 2003-11-18

Similar Documents

Publication Publication Date Title
IL152669A0 (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
IL160630A0 (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
IL160648A0 (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
PL376301A1 (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 and type 2
HUP0102782A3 (en) Salycilanilide as inhibitors of transcription factor nf-kb
HUP0101809A3 (en) Inhibitors of type 5 and type 3 17betha-hydroxysteroid dehydrogenase and methods for their use
AU2001244399A1 (en) Gamma-secretase inhibitors
AU2002213002A1 (en) Antisense inhibition of caspase 6 expression
GB0025782D0 (en) Use of inhibitors
AU8969601A (en) New use of lipase inhibitors
GB2353793B (en) Method of use of corrosion inhibitor compositions
ZA200502909B (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 and type 2.
AUPQ629000A0 (en) Inhibition of fungi
AU2002224550A1 (en) Corrosion inhibitors
AU2001252884A1 (en) Method of dopamine inhibition using l-threo-methylphenidate
AU2002214038A1 (en) Inhibitors of transglutaminases
AU2001251631A1 (en) Hydrazide and alkoxyamide angiogenesis inhibitors
AU1212002A (en) Use of lipase inhibitors
AU2002221882A1 (en) Use of 3-hydroxyl-3-methylglutaryl-coenzyme-a-reductase inhibitors
AU2001250996A1 (en) Compositions and methods for the deoxidation of steel
AU1548801A (en) Melanogenesis inhibitor
AU2001255268A1 (en) Inhibition of cytokine generation
GB0023638D0 (en) Inhibition of corrosion
AU2001240374A1 (en) Inhibition of fungi
ZA200409052B (en) Compositions and methods for the modification of gene expression