IL122120A - Recombinant mva virus containing a foreign gene inserted in a naturally occuring deletion within the genome - Google Patents
Recombinant mva virus containing a foreign gene inserted in a naturally occuring deletion within the genomeInfo
- Publication number
- IL122120A IL122120A IL12212096A IL12212096A IL122120A IL 122120 A IL122120 A IL 122120A IL 12212096 A IL12212096 A IL 12212096A IL 12212096 A IL12212096 A IL 12212096A IL 122120 A IL122120 A IL 122120A
- Authority
- IL
- Israel
- Prior art keywords
- genome
- recombinant mva
- naturally occuring
- foreign gene
- virus containing
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 2
- 230000037430 deletion Effects 0.000 title abstract 2
- 238000012217 deletion Methods 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000013603 viral vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0091—Purification or manufacturing processes for gene therapy compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0055—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10)
- C12N9/0057—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10) with oxygen as acceptor (1.10.3)
- C12N9/0059—Catechol oxidase (1.10.3.1), i.e. tyrosinase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Manufacturing & Machinery (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK78295 | 1995-07-04 | ||
PCT/EP1996/002926 WO1997002355A1 (en) | 1995-07-04 | 1996-07-03 | Recombinant mva virus, and the use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
IL122120A0 IL122120A0 (en) | 1998-04-05 |
IL122120A true IL122120A (en) | 2005-07-25 |
Family
ID=8097499
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12212096A IL122120A (en) | 1995-07-04 | 1996-07-03 | Recombinant mva virus containing a foreign gene inserted in a naturally occuring deletion within the genome |
IL164318A IL164318A (en) | 1995-07-04 | 2004-09-28 | A vaccine that includes a recombinant Vaccinia ancara ankara that has undergone at least one foreign gene inserted into a naturally occurring missing site within the virus genome and its preparation |
IL202448A IL202448A0 (en) | 1995-07-04 | 2009-12-01 | Vaccine comprising recombinant modified vaccine ankara virus and uses thereof |
IL212933A IL212933A0 (en) | 1995-07-04 | 2011-05-17 | Eukaryotic cell comprising a recombinant modified vaccinia ankara (mva) virus |
IL219528A IL219528A0 (en) | 1995-07-04 | 2012-05-02 | Vaccine comprising recombinant modified vaccine ankara virus and uses thereof |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL164318A IL164318A (en) | 1995-07-04 | 2004-09-28 | A vaccine that includes a recombinant Vaccinia ancara ankara that has undergone at least one foreign gene inserted into a naturally occurring missing site within the virus genome and its preparation |
IL202448A IL202448A0 (en) | 1995-07-04 | 2009-12-01 | Vaccine comprising recombinant modified vaccine ankara virus and uses thereof |
IL212933A IL212933A0 (en) | 1995-07-04 | 2011-05-17 | Eukaryotic cell comprising a recombinant modified vaccinia ankara (mva) virus |
IL219528A IL219528A0 (en) | 1995-07-04 | 2012-05-02 | Vaccine comprising recombinant modified vaccine ankara virus and uses thereof |
Country Status (27)
Country | Link |
---|---|
US (6) | US6440422B1 (hu) |
EP (3) | EP1312679B8 (hu) |
JP (3) | JP4312260B2 (hu) |
KR (1) | KR19990028617A (hu) |
CN (3) | CN1782071A (hu) |
AT (3) | ATE239796T1 (hu) |
AU (1) | AU721735B2 (hu) |
BR (1) | BR9609303B8 (hu) |
CA (3) | CA2596274C (hu) |
CZ (1) | CZ292460B6 (hu) |
DE (3) | DE69635172T2 (hu) |
DK (3) | DK1312679T3 (hu) |
EE (3) | EE04199B1 (hu) |
ES (3) | ES2199294T3 (hu) |
HK (2) | HK1009830A1 (hu) |
HU (2) | HU224061B1 (hu) |
IL (5) | IL122120A (hu) |
MX (1) | MX9800025A (hu) |
NO (1) | NO322476B1 (hu) |
NZ (1) | NZ313597A (hu) |
PL (1) | PL186857B1 (hu) |
PT (1) | PT836648E (hu) |
RU (1) | RU2198217C2 (hu) |
SI (3) | SI0836648T1 (hu) |
TW (2) | TW575664B (hu) |
UA (3) | UA68327C2 (hu) |
WO (1) | WO1997002355A1 (hu) |
Families Citing this family (119)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA68327C2 (en) * | 1995-07-04 | 2004-08-16 | Gsf Forschungszentrum Fur Unwe | A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals |
US7118754B1 (en) * | 1996-07-30 | 2006-10-10 | Transgene S.A. | Pharmaceutical composition for treating papillomavirus tumors and infection |
EP0951555A2 (en) * | 1996-09-24 | 1999-10-27 | Bavarian Nordic Research Institute A/S | Recombinant mva virus expressing dengue virus antigens, and the use thereof in vaccines |
MY119381A (en) * | 1996-12-24 | 2005-05-31 | Gsf Forschungszentrum Umwelt | Recombinant mva virus, and the use thereof |
US6969609B1 (en) | 1998-12-09 | 2005-11-29 | The United States Of America As Represented By The Department Of Health And Human Serivces | Recombinant vector expressing multiple costimulatory molecules and uses thereof |
FR2784997A1 (fr) * | 1998-10-22 | 2000-04-28 | Transgene Sa | Materiel biologique pour la preparation de compositions pharmaceutiques destinees au traitement de mammiferes |
US20040265324A1 (en) * | 1999-03-23 | 2004-12-30 | Cardosa Mary Jane | Recombinant MVA virus expressing dengue virus antigens, and the use thereof in vaccines |
ATE412762T1 (de) | 1999-05-28 | 2008-11-15 | Helmholtz Zentrum Muenchen | Vektor zur integration von heterologen sequenzen in poxvirusgenomen |
US20150231227A1 (en) * | 2000-03-02 | 2015-08-20 | Emory University | Compositions and methods for generating an immune response |
EE05633B1 (et) | 2000-03-14 | 2013-02-15 | Mayr Anton | Muundatud vaktsiiniaviirus Ankara (MVA), sellega nakatatud peremeesrakk ning seda sisaldav farmatseutiline kompositsioon, MVA valmistamine ja raviotstarbeline kasutamine |
DE10042598A1 (de) * | 2000-08-30 | 2002-03-28 | Gsf Forschungszentrum Umwelt | Rekombinantes MVA mit der Fähigkeit zur Expression des HER-2/Neu-GENS |
AU2002211654A1 (en) * | 2000-10-10 | 2002-04-22 | Genstar Therapeutics | Minimal adenoviral vector and recombinant vaccines based thereon |
US7445924B2 (en) | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
AU2002231639B2 (en) | 2000-11-23 | 2007-01-04 | Bavarian Nordic A/S | Modified vaccinia ankara virus variant |
US7628980B2 (en) | 2000-11-23 | 2009-12-08 | Bavarian Nordic A/S | Modified vaccinia virus ankara for the vaccination of neonates |
US7740863B2 (en) | 2001-04-06 | 2010-06-22 | Merial | Recombinant vaccine against West Nile Virus |
DE10143490C2 (de) * | 2001-09-05 | 2003-12-11 | Gsf Forschungszentrum Umwelt | Rekombinantes MVA mit der Fähigkeit zur Expression von HCV Struktur-Antigenen |
DE10144664B4 (de) * | 2001-09-11 | 2005-06-09 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Vacciniavirus MVA-E3L-Knock-Out-Mutanten und Verwendung hiervon |
CA2466413C (en) | 2001-12-04 | 2014-11-04 | Bavarian Nordic A/S | Flavivirus ns1 subunit vaccine |
EA006485B1 (ru) * | 2001-12-20 | 2005-12-29 | Бавариан Нордик А/С | Способ выделения и очистки поксвирусов из инфицированных клеток |
EA011233B1 (ru) * | 2002-04-19 | 2009-02-27 | Бавариан Нордик А/С | Применение модифицированного вируса осповакцины анкара для вакцинации новорожденных |
US7501127B2 (en) | 2002-05-16 | 2009-03-10 | Bavarian Nordic A/S | Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of Modified Vaccinia virus Ankara |
SI1407033T1 (sl) | 2002-05-16 | 2006-06-30 | Bavarian Nordic As | Intergenske regije kot insercijska mesta v genomumodificiranega virusavakcinije Ankara (MVA) |
ES2256747T3 (es) * | 2002-05-16 | 2006-07-16 | Bavarian Nordic A/S | Expresion de genes en el virus de la vacuna modificado, usando el promotor ati de la viruela de la vaca. |
NZ538575A (en) | 2002-09-05 | 2007-03-30 | Bavarian Nordic As | Method for the amplification of a virus wherein primary avian cells are cultivated in a serum-free medium comprising growth factors and attachment factors |
DE10249390A1 (de) * | 2002-10-23 | 2004-05-13 | Ruprecht-Karls-Universität Heidelberg | Rekombinante MVA-Stämme als potentielle Impfstoffe gegen P.falciparum-Malaria |
AU2003293675B2 (en) | 2002-11-25 | 2009-04-23 | Bavarian Nordic A/S | Recombinant poxvirus comprising at least two cowpox ATI promoters |
DE602004015418D1 (de) * | 2003-02-18 | 2008-09-11 | Helmholtz Zentrum Muenchen | Rekombinantes mva und verfahren zur erzeugung davon |
EP1601333B1 (en) * | 2003-02-20 | 2013-01-23 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services | Novel insertion sites in pox vectors |
US7731974B2 (en) | 2003-03-27 | 2010-06-08 | Ottawa Hospital Research Institute | Mutant vesicular stomatitis viruses and uses thereof |
NZ542902A (en) | 2003-03-27 | 2007-06-29 | Ottawa Health Research Inst | Mutant vesicular stomatitis viruses and use thereof |
US7163685B2 (en) * | 2003-04-16 | 2007-01-16 | City Of Hope | Human cytomegalovirus antigens expressed in MVA and methods of use |
GB2402391A (en) * | 2003-06-04 | 2004-12-08 | Oxxon Pharmaccines Ltd | Fowlpox recombinant genome |
ES2359473T3 (es) | 2003-07-21 | 2011-05-23 | Transgene S.A. | Citoquinas multifuncionales. |
WO2005017208A1 (en) * | 2003-07-31 | 2005-02-24 | George Mason Intellectual Properties, Inc. | Compositions and methods for treating or preventing hiv infection |
EP1518932A1 (en) * | 2003-09-29 | 2005-03-30 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Modified vaccinia virus Ankara (MVA) mutant and use thereof |
DK1845164T3 (da) | 2003-11-24 | 2010-09-20 | Bavarian Nordic As | Promoterer til ekspression i modificeret vacciniavirus ankara |
US7638132B2 (en) | 2003-12-05 | 2009-12-29 | National University Corporation Hokkaido University | Highly safe smallpox vaccine virus and vaccinia virus vector |
EP1683870A1 (en) * | 2005-01-24 | 2006-07-26 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Vaccines based on the use of MVA |
WO2006113927A2 (en) * | 2005-04-20 | 2006-10-26 | University Of Washington | Immunogenic vaccinia peptides and methods of using same |
US20090060947A1 (en) * | 2006-05-19 | 2009-03-05 | Sanofi Pasteur, Inc. | Immunological compositions |
NZ573437A (en) * | 2006-06-20 | 2012-02-24 | Transgene Sa | Process for producing poxviruses and poxvirus compositions |
US7972605B2 (en) * | 2006-09-08 | 2011-07-05 | Duke University | Modified vaccinia ankara virus vaccine |
EP2839837B1 (en) * | 2006-09-15 | 2019-05-08 | Children's Hospital of Eastern Ontario Research Institute Inc. | Oncolytic farmington rhabdovirus |
EP2596801B1 (en) | 2006-10-06 | 2018-05-02 | Bavarian Nordic A/S | Recombinant modified vaccinia ankara virus encoding a her-2 antigen for use in treating cancer |
US20080241139A1 (en) * | 2006-10-31 | 2008-10-02 | Regents Of The University Of Colorado | Adjuvant combinations comprising a microbial tlr agonist, a cd40 or 4-1bb agonist, and optionally an antigen and the use thereof for inducing a synergistic enhancement in cellular immunity |
US8557764B2 (en) * | 2007-01-26 | 2013-10-15 | The Regents Of The University Of Colorado, A Body Corporate | Methods of modulating immune function |
DK2152736T3 (en) | 2007-05-03 | 2017-09-18 | Lysomab Gmbh | Complement factor H-derived short-consensus repeat (SCR) antibody constructs |
US8003363B2 (en) | 2007-05-14 | 2011-08-23 | Bavarian Nordic A/S | Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines |
WO2008138533A1 (en) * | 2007-05-14 | 2008-11-20 | Bavarian Nordic A/S | Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines |
US8003364B2 (en) | 2007-05-14 | 2011-08-23 | Bavarian Nordic A/S | Purification of vaccinia viruses using hydrophobic interaction chromatography |
US20100285050A1 (en) * | 2007-10-05 | 2010-11-11 | Isis Innovation Limited | Compositions and Methods |
BRPI0800485B8 (pt) * | 2008-01-17 | 2021-05-25 | Univ Minas Gerais | vetores virais recombinantes, composição vacinal para leishmaniose e método de vacinação para leishmaniose |
BRPI0908474A2 (pt) | 2008-02-12 | 2016-07-26 | Sanofi Pasteur Ltd | métodos de uso de cromatografia de troca de íon e de filtração de gel para purificação de vírus causador da catapora |
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