HUP9802217A2 - Rekombináns MVA-vírus és alkalmazása - Google Patents

Rekombináns MVA-vírus és alkalmazása

Info

Publication number
HUP9802217A2
HUP9802217A2 HU9802217A HUP9802217A HUP9802217A2 HU P9802217 A2 HUP9802217 A2 HU P9802217A2 HU 9802217 A HU9802217 A HU 9802217A HU P9802217 A HUP9802217 A HU P9802217A HU P9802217 A2 HUP9802217 A2 HU P9802217A2
Authority
HU
Hungary
Prior art keywords
mva
recombinant
recombinant mva
vectors
antigens
Prior art date
Application number
HU9802217A
Other languages
English (en)
Inventor
Volker Erfle
Marion Ohlmann
Gerd Sutter
Original Assignee
GSF-Forschungszentrum für Umwelt und Gesundheit GmbH.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8097499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9802217(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by GSF-Forschungszentrum für Umwelt und Gesundheit GmbH. filed Critical GSF-Forschungszentrum für Umwelt und Gesundheit GmbH.
Publication of HUP9802217A2 publication Critical patent/HUP9802217A2/hu
Publication of HUP9802217A3 publication Critical patent/HUP9802217A3/hu
Publication of HU224061B1 publication Critical patent/HU224061B1/hu

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0055—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10)
    • C12N9/0057—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10) with oxygen as acceptor (1.10.3)
    • C12N9/0059—Catechol oxidase (1.10.3.1), i.e. tyrosinase
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
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  • Molecular Biology (AREA)
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  • Virology (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Biophysics (AREA)
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  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Manufacturing & Machinery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A találmány tárgyát őlyan rekőmbináns vaccinia vírűsők képezik, melyeka módősítőtt Ankara vaccinia (MVA) vírűsból származnak, az MVA-genőmban egy természetes körülmények között előfőrdűló deléció helyéreinszertált idegen géneket hőrdőznak, és azőkat expresz-szálni képesek.A találmány tárgyát képezi tővábbá a rekőmbináns MVA-vírűsőkalkalmazása pőlipeptidek - példáűl antigének vagy terápiás hatóanya-gők - vagy génterápiában alkalmazható vírűseredetű vektőrőkelőállítására, valamint az antigéneket kódőló rekőmbináns MVA-vírűsőkalkalmazása őltóanyagként. A találmány szerinti rekőmbináns MVA-vírűsők hatékőny és különlegesen biztőnságős expressziós vektőrkéntalkalmazhatók. ŕ
HU9802217A 1995-07-04 1996-07-03 Rekombináns MVA-vírus és alkalmazása HU224061B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK78295 1995-07-04
PCT/EP1996/002926 WO1997002355A1 (en) 1995-07-04 1996-07-03 Recombinant mva virus, and the use thereof

Publications (3)

Publication Number Publication Date
HUP9802217A2 true HUP9802217A2 (hu) 1999-01-28
HUP9802217A3 HUP9802217A3 (en) 1999-09-28
HU224061B1 HU224061B1 (hu) 2005-05-30

Family

ID=8097499

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0402350A HU229261B1 (en) 1995-07-04 1996-07-03 Recombinant mva-virus comprising a gene encoding a hiv net antigen ar an antigen determinant and use thereof
HU9802217A HU224061B1 (hu) 1995-07-04 1996-07-03 Rekombináns MVA-vírus és alkalmazása

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU0402350A HU229261B1 (en) 1995-07-04 1996-07-03 Recombinant mva-virus comprising a gene encoding a hiv net antigen ar an antigen determinant and use thereof

Country Status (27)

Country Link
US (6) US6440422B1 (hu)
EP (3) EP1312678B1 (hu)
JP (3) JP4312260B2 (hu)
KR (1) KR19990028617A (hu)
CN (3) CN1554764B (hu)
AT (3) ATE304057T1 (hu)
AU (1) AU721735B2 (hu)
BR (1) BR9609303B8 (hu)
CA (3) CA2225278C (hu)
CZ (1) CZ292460B6 (hu)
DE (3) DE69635173T2 (hu)
DK (3) DK1312679T3 (hu)
EE (3) EE04199B1 (hu)
ES (3) ES2249647T3 (hu)
HK (2) HK1009830A1 (hu)
HU (2) HU229261B1 (hu)
IL (5) IL122120A (hu)
MX (1) MX9800025A (hu)
NO (1) NO322476B1 (hu)
NZ (1) NZ313597A (hu)
PL (1) PL186857B1 (hu)
PT (1) PT836648E (hu)
RU (1) RU2198217C2 (hu)
SI (3) SI1312678T1 (hu)
TW (2) TW575664B (hu)
UA (3) UA68327C2 (hu)
WO (1) WO1997002355A1 (hu)

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