IE912442A1 - Peptide Derivatives - Google Patents

Peptide Derivatives

Info

Publication number
IE912442A1
IE912442A1 IE244291A IE244291A IE912442A1 IE 912442 A1 IE912442 A1 IE 912442A1 IE 244291 A IE244291 A IE 244291A IE 244291 A IE244291 A IE 244291A IE 912442 A1 IE912442 A1 IE 912442A1
Authority
IE
Ireland
Prior art keywords
compound
peptide
protected
group
acid addition
Prior art date
Application number
IE244291A
Other languages
English (en)
Other versions
IE912442L (en
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of IE912442L publication Critical patent/IE912442L/en
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of IE912442A1 publication Critical patent/IE912442A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IE244291A 1986-10-13 1991-07-12 Peptide Derivatives IE912442A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE3634826 1986-10-13
DE3634797 1986-10-13
DE3634825 1986-10-13
DE3712626 1987-04-14
CH315387 1987-08-17

Publications (2)

Publication Number Publication Date
IE912442L IE912442L (en) 1988-04-13
IE912442A1 true IE912442A1 (en) 1992-02-12

Family

ID=27509117

Family Applications (1)

Application Number Title Priority Date Filing Date
IE244291A IE912442A1 (en) 1986-10-13 1991-07-12 Peptide Derivatives

Country Status (23)

Country Link
US (1) US5656721A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JPH0645639B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR960016861B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (2) AU617986B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE1003752A4 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1340985C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (2) CH680512A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3790635T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK174337B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2007418A6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI874495A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2609991A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (2) GB2199829B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR871567B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (3) HU906341D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE912442A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU87014A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL194729C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ222133A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL157156B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT85904B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (2) SE8703938L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1988002756A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
DE3845000C2 (de) * 1987-07-10 1998-11-19 Novartis Ag Anwendung von Octreotid zur Behandlung von Brustkrebs
AU632468B2 (en) * 1988-02-01 1993-01-07 Upjohn Company, The Renin inhibiting peptides with polar end groups
GB2218102B (en) * 1988-04-08 1992-09-16 Sandoz Ltd Calcitonin peptide derivatives
DE3910667A1 (de) * 1988-04-11 1989-10-19 Sandoz Ag Peptidderivate
GB8813339D0 (en) * 1988-06-06 1988-07-13 Sandoz Ltd Improvements in/relating to organic compounds
FR2638968B1 (fr) * 1988-11-11 1994-10-07 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
US5776894A (en) * 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
IT1229514B (it) * 1989-01-30 1991-09-03 Farmhispania S A A Montme Glicoconiugati anfifilici sintetici per impiego neurologico.
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
IT1260156B (it) * 1992-08-03 1996-03-28 Fidia Spa Derivati dell'acido neuraminico
TW263437B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1992-09-24 1995-11-21 Takeda Pharm Industry Co Ltd
US5710244A (en) * 1992-12-31 1998-01-20 Labroo; Virender M. Derivatized calcitonins
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
SI0788509T1 (en) * 1993-08-09 2003-10-31 Societe De Conseils De Recherches Therapeutic peptide derivatives
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
JP3896430B2 (ja) * 1996-07-15 2007-03-22 アークレイ株式会社 糖化アミノ化合物の製造方法
IL119029A0 (en) * 1996-08-07 1996-11-14 Yeda Res & Dev Long-acting drugs and pharamaceutical compositions comprising them
EP0981363B1 (en) 1997-05-13 2003-07-30 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Somatostatin agonists for decreasing body weight
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
AU8019798A (en) 1997-05-13 1998-12-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Method and compositions for treating hyperlipidemia and other conditions
CA2320962C (en) * 1998-02-13 2011-04-19 Amylin Pharmaceuticals, Inc. Novel mixed amylin activity compounds
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US20050037490A1 (en) * 1999-10-29 2005-02-17 Lawrence Rosenberg Medium for preparing dedifferentiated cells
EP1381396B1 (en) * 2001-04-23 2009-04-01 Mallinckrodt Inc. Tc and re labeled radioactive glycosylated octreotide derivatives
PT2062914E (pt) 2001-06-08 2014-07-18 Ipsen Pharma Sas Análogos quiméricos de somatostatina-dopamina
JP4615221B2 (ja) * 2002-02-27 2011-01-19 フェリング ベスローテン フェンノートシャップ ヘプタペプチドオキシトシンアナログを製造するための中間体及び方法
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
ATE458491T1 (de) * 2005-08-26 2010-03-15 Univ Leland Stanford Junior Verfahren zur behandlung von kopfschmerzen durch verabreichung von oxytocin
ATE549011T1 (de) 2005-11-10 2012-03-15 Chemi Spa Formulierungen mit verzögerter freisetzung, die somatostatin-analoge wachstumshormoninhibitoren enthalten
WO2008011168A2 (en) * 2006-07-21 2008-01-24 Amgen Inc. Glycosylated peptide antagonists of the bradykinin b1 receptor
EP2952522B1 (en) 2007-01-31 2019-10-30 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
ES2430067T3 (es) 2007-03-28 2013-11-18 President And Fellows Of Harvard College Polipéptidos cosidos
CN101821281A (zh) 2007-09-25 2010-09-01 格礼卡姆股份公司 糖蛋白和糖基化的细胞以及其制备方法
WO2009062200A1 (en) * 2007-11-09 2009-05-14 University Of Tennessee Research Foundation Anti-inflammatory quinic acid derivatives for oral administration
CN102083451A (zh) 2008-06-12 2011-06-01 赛恩泰新公司 癌症的抑制
EP3590956A1 (en) 2008-06-12 2020-01-08 Ipsen Bioinnovation Limited Suppression of neuroendocrine diseases
WO2010089757A2 (en) * 2008-11-07 2010-08-12 Usv Limited An improved process for synthesis of cyclic octapeptide
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
WO2012021876A2 (en) 2010-08-13 2012-02-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP6178238B2 (ja) 2011-09-04 2017-08-09 株式会社糖鎖工学研究所 糖鎖付加ポリペプチドおよび当該ポリペプチドを含む医薬組成物
SG10201601327RA (en) 2011-09-04 2016-03-30 Glytech Inc Glycosylated polypeptide and drug composition containing said polypeptide
JP6342808B2 (ja) 2011-10-18 2018-06-13 エイルロン セラピューティクス，インコーポレイテッド ペプチドミメティック大環状化合物
JP6450192B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド トリアゾール架橋した、およびチオエーテル架橋したペプチドミメティック大環状化合物
SG10201606775YA (en) 2012-02-15 2016-10-28 Aileron Therapeutics Inc Peptidomimetic macrocycles
US9604919B2 (en) 2012-11-01 2017-03-28 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
CA2918787A1 (en) 2013-06-13 2014-12-18 George Tachas Combination therapy
SG10201902594QA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
ES2963707T3 (es) 2015-01-07 2024-04-01 Tonix Pharma Ltd Formulaciones de oxitocina que contienen magnesio y métodos de uso
CA2979847A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
SMT202500100T1 (it) 2016-04-12 2025-05-12 Tonix Pharma Ltd Formulazioni di ossitocina contenenti magnesio e metodi d'uso
EP3713660A1 (en) 2017-11-22 2020-09-30 Dauntless 1, Inc. Membrane emulsification device for microsphere creation
EP3713545A1 (en) 2017-11-22 2020-09-30 Dauntless 1, Inc. Therapeutic compound formulations
WO2020005842A1 (en) 2018-06-25 2020-01-02 Dauntless 2, Inc. Membrane emulsification device with impeller for microsphere creation
CN114026107A (zh) 2019-04-16 2022-02-08 巴克姆股份公司 二硫键肽的生产
CA3199254A1 (en) * 2020-10-22 2022-04-28 The Trustees Of Indiana University Molecular designs of glucose-responsive and glucose-cleavable insulin analogues

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254023A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Synthesis of peptide alcohols by the solid phase method
US4280953A (en) * 1979-11-08 1981-07-28 The Salk Institute For Biological Studies Glycosylated analogs of somatostatin
ATE2512T1 (de) * 1979-11-27 1983-03-15 Sandoz Ag Polypeptide, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen, die diese polypeptide enthalten, und ihre verwendung.
FR2522967B1 (fr) * 1982-03-15 1986-03-07 Anvar Conjugues d'haptenes et de muramyl-peptides, doues d'activite immunogene et compositions les contenant
US4444683A (en) * 1982-11-17 1984-04-24 University Of Utah Glycosylated insulin derivatives
US4483792A (en) * 1982-11-17 1984-11-20 Kim Wan S Glycosylated insulin derivatives
FR2546163B1 (fr) * 1983-05-16 1987-10-09 Centre Nat Rech Scient Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
FR2548673B1 (fr) * 1983-07-05 1985-10-04 Essilor Int Polymeres supports de produits actifs relargables et leur procede de preparation
LU85269A1 (fr) * 1984-03-26 1985-10-14 Techland S A Composes nouveaux de somatostatine,procede pour leur synthese,preparation a usage veterinaire contenant lesdits composes et procede pour le traitement d'animaux
US4564998A (en) * 1984-10-19 1986-01-21 Westinghouse Electric Corp. Coil winding methods and apparatus
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin
FI860708A7 (fi) * 1985-02-20 1986-08-21 Ciba Geigy Ag Acylerade hexosderivat och foerfarande foer deras framstaellning.
JPS61264260A (ja) * 1985-05-17 1986-11-22 Rikagaku Kenkyusho アルデヒド化多孔性高分子材料によるタンパク質の除去方法
AU597909B2 (en) * 1985-10-09 1990-06-14 Procter & Gamble Company, The Granular detergent compositions having improved solubility
SE8506094D0 (sv) * 1985-12-20 1985-12-20 Astra Laekemedel Ab New antibacterial agents and intermediates therefor
JPS63165411A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製法
JPS63165410A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製造方法
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
US4859736A (en) * 1987-03-30 1989-08-22 Ciba-Geigy Corporation Synthetic polystyrene resin and its use in solid phase peptide synthesis
CH679045A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1987-06-29 1991-12-13 Sandoz Ag

Also Published As

Publication number Publication date
KR880005153A (ko) 1988-06-28
HU906341D0 (en) 1991-04-29
CA1340985C (en) 2000-05-09
SE9301172L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1900-01-01
KR960016861B1 (ko) 1996-12-23
DK174337B1 (da) 2002-12-16
GB2199829A (en) 1988-07-20
DK532787A (da) 1988-04-14
DE3790635T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-10-06
WO1988002756A3 (en) 1988-07-14
AU7956487A (en) 1988-04-14
HU906340D0 (en) 1991-04-29
GR871567B (en) 1988-02-16
ES2007418A6 (es) 1989-06-16
CH680512A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1992-09-15
GB2199831B (en) 1991-04-17
PT85904B (pt) 1990-08-31
NL194729C (nl) 2003-01-07
NL8702345A (nl) 1988-05-02
PT85904A (en) 1987-11-01
GB2199831A (en) 1988-07-20
PL268173A1 (en) 1988-09-01
FI874495A0 (fi) 1987-10-12
DK532787D0 (da) 1987-10-12
NZ222133A (en) 1993-02-25
SE9301172D0 (sv) 1993-04-07
US5656721A (en) 1997-08-12
AU8015091A (en) 1991-10-31
AU617986B2 (en) 1991-12-12
WO1988002756A2 (en) 1988-04-21
BE1003752A4 (fr) 1992-06-09
FI874495L (fi) 1988-04-14
SE8703938L (sv) 1988-04-14
JPS63101399A (ja) 1988-05-06
PL157156B1 (pl) 1992-05-29
HUT46710A (en) 1988-11-28
FI874495A7 (fi) 1988-04-14
FR2609991B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1995-03-10
GB8723737D0 (en) 1987-11-11
CH682632A5 (de) 1993-10-29
SE518630C2 (sv) 2002-11-05
JP2744910B2 (ja) 1998-04-28
IE912442L (en) 1988-04-13
GB2199829B (en) 1991-04-17
AU634664B2 (en) 1993-02-25
SE8703938D0 (sv) 1987-10-12
FR2609991A1 (fr) 1988-07-29
JPH0645639B2 (ja) 1994-06-15
LU87014A1 (fr) 1988-05-03
NL194729B (nl) 2002-09-02
GB8800537D0 (en) 1988-02-10
JPH0314599A (ja) 1991-01-23
HU206890B (en) 1993-01-28

Similar Documents

Publication Publication Date Title
IE912442A1 (en) Peptide Derivatives
FI64576B (fi) Foerfarande foer framstaellning av en terapeutiskt anvaendbar somatostatinanalog
AU5433096A (en) Cyclic prodrugs of peptides and peptide nucleic acids having improved metabolic stability and cell membrane permeability
JPH04504723A (ja) 線状ソマトスタチン類似体
US4261885A (en) Novel somatostatin analogue
CN110128526B (zh) 长效化艾塞那肽衍生物及其盐与制备方法和用途
US4314999A (en) N-Acyl derivatives of glucosamine having antitumor chemotherapeutic acitivity
EP0016612B1 (en) Peptides having ubiquitin-like activity, process for their preparation, therapeutic compositions containing them and their use
Folkers et al. Structure and synthesis of the thyrotropin-releasing hormone
NO141262B (no) Analogifremgangsmaate til fremstilling av terapeutisk virksomme tripeptider
US4468383A (en) Dimeric enkephalins
FI75175C (fi) Process foer framstaellning av n-karboxialkylprolin innehaollande tripeptider.
US7365055B2 (en) Derivatives of morphine-6-glucuronide, pharmaceutical compositions containing them, their preparation method and their uses
CA2169072A1 (en) Novel tripeptides useful in immune and cns therapy
GB2185486A (en) Conjugate of alpha-melanotropin with p-L-sarcolysine (melphalan)
GB2233652A (en) Synthesis of peptide alcohols
CA2385910A1 (en) Somatostatin analogs for the treatment of cancer
EP0050828B1 (en) Tetrapeptide acylhydrazides, their production and use
EP0393786B1 (en) New retro-inverse, one- or more bond bearing analogues of thymopentin, a method for synthesizing the same and their employment for the preparation of pharmaceutical
CN116789744A (zh) 一类阿片/神经肽ff受体多靶点分子dn-9的订书肽类似物及其制备和应用
SE447482B (sv) Forfarande for framstellning av somatostatinanaloger
DE3790635B4 (de) Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür
GB2224280A (en) Modified somatostatin
FR2619566A1 (fr) Procede de preparation d'un peptide-alcool
IE65159B1 (en) Solid phase synthesis of peptide alcohols