NL194729B - Werkwijze voor de bereiding van peptidealcoholen via vaste fase. - Google Patents

Werkwijze voor de bereiding van peptidealcoholen via vaste fase.

Info

Publication number
NL194729B
NL194729B NL8702345A NL8702345A NL194729B NL 194729 B NL194729 B NL 194729B NL 8702345 A NL8702345 A NL 8702345A NL 8702345 A NL8702345 A NL 8702345A NL 194729 B NL194729 B NL 194729B
Authority
NL
Netherlands
Prior art keywords
preparation
solid phase
via solid
alcohols via
peptide alcohols
Prior art date
Application number
NL8702345A
Other languages
English (en)
Other versions
NL194729C (nl
NL8702345A (nl
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NL8702345A publication Critical patent/NL8702345A/nl
Publication of NL194729B publication Critical patent/NL194729B/nl
Application granted granted Critical
Publication of NL194729C publication Critical patent/NL194729C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
NL8702345A 1986-10-13 1987-10-01 Werkwijze voor de bereiding van peptidealcoholen via vaste fase. NL194729C (nl)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DE3634826 1986-10-13
DE3634797 1986-10-13
DE3634826 1986-10-13
DE3634825 1986-10-13
DE3634797 1986-10-13
DE3634825 1986-10-13
DE3712626 1987-04-14
DE3712626 1987-04-14
CH315387 1987-08-17
CH315387 1987-08-17

Publications (3)

Publication Number Publication Date
NL8702345A NL8702345A (nl) 1988-05-02
NL194729B true NL194729B (nl) 2002-09-02
NL194729C NL194729C (nl) 2003-01-07

Family

ID=27509117

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8702345A NL194729C (nl) 1986-10-13 1987-10-01 Werkwijze voor de bereiding van peptidealcoholen via vaste fase.

Country Status (23)

Country Link
US (1) US5656721A (nl)
JP (2) JPH0645639B2 (nl)
KR (1) KR960016861B1 (nl)
AU (2) AU617986B2 (nl)
BE (1) BE1003752A4 (nl)
CA (1) CA1340985C (nl)
CH (2) CH682632A5 (nl)
DE (1) DE3790635T1 (nl)
DK (1) DK174337B1 (nl)
ES (1) ES2007418A6 (nl)
FI (1) FI874495A (nl)
FR (1) FR2609991A1 (nl)
GB (2) GB2199829B (nl)
GR (1) GR871567B (nl)
HU (3) HU906340D0 (nl)
IE (1) IE912442A1 (nl)
LU (1) LU87014A1 (nl)
NL (1) NL194729C (nl)
NZ (1) NZ222133A (nl)
PL (1) PL157156B1 (nl)
PT (1) PT85904B (nl)
SE (2) SE8703938L (nl)
WO (1) WO1988002756A2 (nl)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
DE3845000C2 (de) * 1987-07-10 1998-11-19 Novartis Ag Anwendung von Octreotid zur Behandlung von Brustkrebs
EP0329295A1 (en) * 1988-02-01 1989-08-23 The Upjohn Company Renin inhibiting peptides with polar end groups
GB2218102B (en) * 1988-04-08 1992-09-16 Sandoz Ltd Calcitonin peptide derivatives
DE3910667A1 (de) * 1988-04-11 1989-10-19 Sandoz Ag Peptidderivate
GB8813339D0 (en) * 1988-06-06 1988-07-13 Sandoz Ltd Improvements in/relating to organic compounds
FR2638968B1 (fr) * 1988-11-11 1994-10-07 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
US5776894A (en) * 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
IT1229514B (it) * 1989-01-30 1991-09-03 Farmhispania S A A Montme Glicoconiugati anfifilici sintetici per impiego neurologico.
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
IT1260156B (it) * 1992-08-03 1996-03-28 Fidia Spa Derivati dell'acido neuraminico
TW263437B (nl) * 1992-09-24 1995-11-21 Takeda Pharm Industry Co Ltd
US5710244A (en) * 1992-12-31 1998-01-20 Labroo; Virender M. Derivatized calcitonins
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
ATE284413T1 (de) * 1993-08-09 2004-12-15 Sod Conseils Rech Applic Therapeutische peptid derivate
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
JP3896430B2 (ja) * 1996-07-15 2007-03-22 アークレイ株式会社 糖化アミノ化合物の製造方法
IL119029A0 (en) * 1996-08-07 1996-11-14 Yeda Res & Dev Long-acting drugs and pharamaceutical compositions comprising them
DE69816808T2 (de) 1997-05-13 2004-04-15 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatin agoniste zur reduzierung von körpergewicht
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
EP0981364B1 (en) 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Method and compositions for treating hyperlipidemia
DE69943039D1 (de) * 1998-02-13 2011-01-27 Amylin Pharmaceuticals Inc Neue verbindungen mit gemischter amylin aktivität
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US20050037490A1 (en) * 1999-10-29 2005-02-17 Lawrence Rosenberg Medium for preparing dedifferentiated cells
US7589061B2 (en) * 2001-04-23 2009-09-15 Mallinckrodt Inc. Tc and Re labeler radioactive glycosylated octreotide derivatives
DK1401863T3 (da) 2001-06-08 2009-05-25 Ipsen Pharma Kimære somatostatin-dopamin-analoge
DE60309847T2 (de) * 2002-02-27 2007-10-18 Ferring B.V. Zwischenprodukte und verfahren zur herstellung von heptapeptid-oxytocinanaloga
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JP2009506076A (ja) 2005-08-26 2009-02-12 ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ 三叉神経疼痛のための薬物送達のための治療手順
EP1787658B1 (en) 2005-11-10 2012-03-14 CHEMI S.p.A. Sustained release formulations of somatostatin analogue inhibitors of growth hormone
WO2008011168A2 (en) * 2006-07-21 2008-01-24 Amgen Inc. Glycosylated peptide antagonists of the bradykinin b1 receptor
WO2008095063A1 (en) 2007-01-31 2008-08-07 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
WO2009040363A1 (en) 2007-09-25 2009-04-02 Glycom Aps Glycoproteins and glycosylated cells and a method for the preparation of the same
AU2008323683B2 (en) * 2007-11-09 2014-10-02 University Of Tennessee Research Foundation Anti-inflammatory quinic acid derivatives for oral administration
JP5799397B2 (ja) 2008-06-12 2015-10-28 イプセン・バイオイノベーション・リミテッドＩｐｓｅｎ Ｂｉｏｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ 癌の抑制
EP2719392B1 (en) 2008-06-12 2019-07-24 Ipsen Bioinnovation Limited Fusion proteins for use in the treatment of acromegaly
WO2010089757A2 (en) * 2008-11-07 2010-08-12 Usv Limited An improved process for synthesis of cyclic octapeptide
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
US9422357B2 (en) 2011-09-04 2016-08-23 Glytech, Inc. Glycosylated polypeptide and drug composition containing said polypeptide
US9441024B2 (en) 2011-09-04 2016-09-13 Glytech, Inc. Glycosylated polypeptide and drug composition containing said polypeptide
AU2012326026B2 (en) 2011-10-18 2017-04-13 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
WO2013123267A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CN112500466B (zh) 2012-02-15 2022-05-03 艾瑞朗医疗公司 拟肽大环化合物
AU2013337388B2 (en) 2012-11-01 2018-08-02 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
WO2014197938A1 (en) 2013-06-13 2014-12-18 Antisense Therapeutics Ltd Combination therapy
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
JP7030517B2 (ja) 2015-01-07 2022-03-07 トライジェミナ， インコーポレイテッド マグネシウム含有オキシトシン製剤および使用の方法
KR20170129879A (ko) 2015-03-20 2017-11-27 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 용도
EP3713545A1 (en) 2017-11-22 2020-09-30 Dauntless 1, Inc. Therapeutic compound formulations
EP3713660A1 (en) 2017-11-22 2020-09-30 Dauntless 1, Inc. Membrane emulsification device for microsphere creation
WO2020005842A1 (en) 2018-06-25 2020-01-02 Dauntless 2, Inc. Membrane emulsification device with impeller for microsphere creation
CN114026107A (zh) 2019-04-16 2022-02-08 巴克姆股份公司 二硫键肽的生产
CA3199254A1 (en) * 2020-10-22 2022-04-28 The Trustees Of Indiana University Molecular designs of glucose-responsive and glucose-cleavable insulin analogues

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254023A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Synthesis of peptide alcohols by the solid phase method
US4280953A (en) * 1979-11-08 1981-07-28 The Salk Institute For Biological Studies Glycosylated analogs of somatostatin
DE19375086I2 (de) * 1979-11-27 2003-01-09 Novartis Ag Polypeptide Verfahren zu ihrer Herstellung pharmazeutische Zusammensetzungen die diese Polypeptide enthalten und ihre Verwendung
FR2522967B1 (fr) * 1982-03-15 1986-03-07 Anvar Conjugues d'haptenes et de muramyl-peptides, doues d'activite immunogene et compositions les contenant
US4444683A (en) * 1982-11-17 1984-04-24 University Of Utah Glycosylated insulin derivatives
US4483792A (en) * 1982-11-17 1984-11-20 Kim Wan S Glycosylated insulin derivatives
FR2546163B1 (fr) * 1983-05-16 1987-10-09 Centre Nat Rech Scient Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
FR2548673B1 (fr) * 1983-07-05 1985-10-04 Essilor Int Polymeres supports de produits actifs relargables et leur procede de preparation
LU85269A1 (fr) * 1984-03-26 1985-10-14 Techland S A Composes nouveaux de somatostatine,procede pour leur synthese,preparation a usage veterinaire contenant lesdits composes et procede pour le traitement d'animaux
US4564998A (en) * 1984-10-19 1986-01-21 Westinghouse Electric Corp. Coil winding methods and apparatus
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin
EP0192611A3 (de) * 1985-02-20 1988-05-11 Ciba-Geigy Ag Acylierte Hexosederivate und Verfahren zu ihrer Herstellung
JPS61264260A (ja) * 1985-05-17 1986-11-22 Rikagaku Kenkyusho アルデヒド化多孔性高分子材料によるタンパク質の除去方法
CA1337041C (en) * 1985-10-09 1995-09-19 Brett Alan Evans Granular detergent compositions having improved solubility
SE8506094D0 (sv) * 1985-12-20 1985-12-20 Astra Laekemedel Ab New antibacterial agents and intermediates therefor
JPS63165410A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製造方法
JPS63165411A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製法
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
US4859736A (en) * 1987-03-30 1989-08-22 Ciba-Geigy Corporation Synthetic polystyrene resin and its use in solid phase peptide synthesis
CH679045A5 (nl) * 1987-06-29 1991-12-13 Sandoz Ag

Also Published As

Publication number Publication date
FR2609991B1 (nl) 1995-03-10
LU87014A1 (fr) 1988-05-03
GB2199831B (en) 1991-04-17
NL194729C (nl) 2003-01-07
HU906340D0 (en) 1991-04-29
ES2007418A6 (es) 1989-06-16
JP2744910B2 (ja) 1998-04-28
KR880005153A (ko) 1988-06-28
WO1988002756A3 (en) 1988-07-14
DE3790635T1 (nl) 1988-10-06
AU617986B2 (en) 1991-12-12
GB2199829A (en) 1988-07-20
AU8015091A (en) 1991-10-31
JPS63101399A (ja) 1988-05-06
CH682632A5 (de) 1993-10-29
NL8702345A (nl) 1988-05-02
KR960016861B1 (ko) 1996-12-23
CH680512A5 (nl) 1992-09-15
HUT46710A (en) 1988-11-28
JPH0314599A (ja) 1991-01-23
PT85904A (en) 1987-11-01
IE912442L (en) 1988-04-13
JPH0645639B2 (ja) 1994-06-15
SE518630C2 (sv) 2002-11-05
AU634664B2 (en) 1993-02-25
FR2609991A1 (fr) 1988-07-29
US5656721A (en) 1997-08-12
GR871567B (en) 1988-02-16
GB8800537D0 (en) 1988-02-10
HU206890B (en) 1993-01-28
DK532787D0 (da) 1987-10-12
SE8703938L (sv) 1988-04-14
SE8703938D0 (sv) 1987-10-12
FI874495A (fi) 1988-04-14
GB2199831A (en) 1988-07-20
DK174337B1 (da) 2002-12-16
SE9301172D0 (sv) 1993-04-07
DK532787A (da) 1988-04-14
PT85904B (pt) 1990-08-31
PL268173A1 (en) 1988-09-01
BE1003752A4 (fr) 1992-06-09
CA1340985C (en) 2000-05-09
PL157156B1 (pl) 1992-05-29
WO1988002756A2 (en) 1988-04-21
SE9301172L (nl) 1900-01-01
FI874495A0 (fi) 1987-10-12
NZ222133A (en) 1993-02-25
GB8723737D0 (en) 1987-11-11
AU7956487A (en) 1988-04-14
GB2199829B (en) 1991-04-17
HU906341D0 (en) 1991-04-29
IE912442A1 (en) 1992-02-12

Similar Documents

Publication Publication Date Title
NL194729B (nl) Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
NL185518C (nl) Werkwijze voor het continu bereiden van hoogmoleculair polybutyleentereftalaat.
NL990002I1 (nl) Rechtsdraaiend enenantiomeer van alfa (4,5,6,7-tetrahydrothienoÄ3,2-cÄ007fÜ-pyrid-5-yl)(2-chloorfenyl) methylacetaat, werkwijze voor de bereiding daarvan en deze bevattende farmaceutische preparaten.
ES2021699B3 (es) Proceso para la preparacion de esteres.
NL194042B (nl) Werkwijze voor de bereiding van 3-fenyl-4-cyaanpyrrolen.
NL187486C (nl) Werkwijze voor de hydroxy-alkylering van een polysaccharide.
NL7801367A (nl) Werkwijze voor de bereiding en afscheiding van p-xyleen.
NO873183L (no) Fremgangsmaate til fremstilling av reninhemmende di- og tri-peptider.
NL192660B (nl) Inrichting voor de bereiding van sojaboonvlokken.
NL192249B (nl) Werkwijze voor het micro-inkapselen door fasescheiding van in water oplosbare geneeskrachtige stoffen.
NL194747B (nl) Preparaat voor de afgifte van diltiazem.
NL7904411A (nl) Werkwijze voor de bereiding van een eiwitfraktie uit zonnebloemzaadmeel.
NL7900615A (nl) Werkwijze voor de bereiding van fluorbenzonitrilen.
NL7903036A (nl) Werkwijze voor de bereiding van propeen-etheen-blok- copolymeren.
NL192187B (nl) Werkwijze voor de bereiding van caseïnaten.
NL7901344A (nl) Werkwijze voor de bereiding van fthalocyaninepigmen- ten.
NL181923C (nl) Werkwijze voor de bereiding van beta-aminopropionamide.
NL183898C (nl) Werkwijze voor de bereiding van cefamycine c.
NL7903251A (nl) Werkwijze voor de bereiding van cefalosporinen.
NL193832B (nl) Hoge-druk-proces voor het bereiden van melamine.
NL192457B (nl) Werkwijze voor het bereiden van dihydroxycyclobuteendion.
NL192112B (nl) Werkwijze voor de bereiding van aspartaam.
NL193407B (nl) Werkwijze voor de bereiding van 3-exomethyleencefamderivaten.
NL192519B (nl) Werkwijze voor het bereiden van zeer zuiver formaldehyde.
NL189253C (nl) Werkwijze voor de bereiding van 2-mercapto-1-ethanol.

Legal Events

Date Code Title Description
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
CNR Transfer of rights (patent application after its laying open for public inspection)

Free format text: NOVARTIS AG

V4 Discontinued because of reaching the maximum lifetime of a patent

Effective date: 20071001