US7060808B1
(en)
*
|
1995-06-07 |
2006-06-13 |
Imclone Systems Incorporated |
Humanized anti-EGF receptor monoclonal antibody
|
US20030224001A1
(en)
*
|
1998-03-19 |
2003-12-04 |
Goldstein Neil I. |
Antibody and antibody fragments for inhibiting the growth of tumors
|
ZA200007412B
(en)
*
|
1998-05-15 |
2002-03-12 |
Imclone Systems Inc |
Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases.
|
CZ20014083A3
(cs)
*
|
1999-05-14 |
2002-08-14 |
Imclone Systems Incorporated |
Léčivo pro indikaci růstu refrakterních nádorů
|
AU2001295002B2
(en)
*
|
2000-08-09 |
2007-05-31 |
Imclone Systems Incorporated |
Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
US20080008704A1
(en)
*
|
2001-03-16 |
2008-01-10 |
Mark Rubin |
Methods of treating colorectal cancer with anti-epidermal growth factor antibodies
|
EP2335728A1
(en)
|
2001-05-11 |
2011-06-22 |
Ludwig Institute for Cancer Research Ltd. |
Specific binding proteins and uses thereof
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
US7595378B2
(en)
|
2001-06-13 |
2009-09-29 |
Genmab A/S |
Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
|
US20050271663A1
(en)
*
|
2001-06-28 |
2005-12-08 |
Domantis Limited |
Compositions and methods for treating inflammatory disorders
|
ATE477280T1
(de)
*
|
2001-06-28 |
2010-08-15 |
Domantis Ltd |
Doppelspezifischer ligand und dessen verwendung
|
CA2472937C
(en)
|
2002-01-11 |
2014-06-17 |
Biomarin Pharmaceutical, Inc. |
Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
|
US7662925B2
(en)
*
|
2002-03-01 |
2010-02-16 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
US20090042291A1
(en)
*
|
2002-03-01 |
2009-02-12 |
Xencor, Inc. |
Optimized Fc variants
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
PT1517921E
(pt)
*
|
2002-06-28 |
2006-09-29 |
Domantis Ltd |
Ligandos duplamente especificos com semi-vida no soro aumentada
|
US9321832B2
(en)
*
|
2002-06-28 |
2016-04-26 |
Domantis Limited |
Ligand
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
SI1523496T1
(sl)
*
|
2002-07-18 |
2011-11-30 |
Merus B V |
Rekombinantno proizvajanje zmesi protiteles
|
JP2006523090A
(ja)
*
|
2002-12-27 |
2006-10-12 |
ドマンティス リミテッド |
リガンドに、そしてリガンド受容体に特異的な二重特異性単一ドメイン抗体
|
DE10303974A1
(de)
|
2003-01-31 |
2004-08-05 |
Abbott Gmbh & Co. Kg |
Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
|
US8388955B2
(en)
*
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
US20090010920A1
(en)
*
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
EP1622941A2
(en)
*
|
2003-03-20 |
2006-02-08 |
ImClone Systems Incorporated |
Method of producing an antibody to epidermal growth factor receptor
|
CA2450289A1
(en)
*
|
2003-03-20 |
2005-05-19 |
Imclone Systems Incorporated |
Method of producing an antibody to epidermal growth factor receptor
|
WO2004106375A1
(en)
|
2003-05-30 |
2004-12-09 |
Merus Biopharmaceuticals B.V. I.O. |
Fab library for the preparation of anti vegf and anti rabies virus fabs
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
US8101720B2
(en)
|
2004-10-21 |
2012-01-24 |
Xencor, Inc. |
Immunoglobulin insertions, deletions and substitutions
|
US9714282B2
(en)
|
2003-09-26 |
2017-07-25 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
GB0324368D0
(en)
*
|
2003-10-17 |
2003-11-19 |
Univ Cambridge Tech |
Polypeptides including modified constant regions
|
DK1737971T3
(da)
|
2004-01-20 |
2017-11-13 |
Merus Nv |
Blandinger af bindingsproteiner
|
US7767792B2
(en)
*
|
2004-02-20 |
2010-08-03 |
Ludwig Institute For Cancer Research Ltd. |
Antibodies to EGF receptor epitope peptides
|
WO2005090407A1
(en)
*
|
2004-03-19 |
2005-09-29 |
Imclone Systems Incorporated |
Human anti-epidermal growth factor receptor antibody
|
WO2006020258A2
(en)
*
|
2004-07-17 |
2006-02-23 |
Imclone Systems Incorporated |
Novel tetravalent bispecific antibody
|
EP2311874B1
(en)
|
2004-07-22 |
2017-05-31 |
Erasmus University Medical Center Rotterdam |
Binding molecules
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
US8546543B2
(en)
|
2004-11-12 |
2013-10-01 |
Xencor, Inc. |
Fc variants that extend antibody half-life
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
DK2325207T3
(en)
|
2004-11-12 |
2017-06-06 |
Xencor Inc |
Fc variants with altered binding to FcRn
|
WO2006082515A2
(en)
*
|
2005-02-07 |
2006-08-10 |
Glycart Biotechnology Ag |
Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof
|
CN100362018C
(zh)
*
|
2005-03-02 |
2008-01-16 |
上海张江生物技术有限公司 |
重组抗egfr单克隆抗体
|
EP2551282A3
(en)
|
2005-03-23 |
2013-02-13 |
Genmab A/S |
Antibodies against CD38 for treatment of multiple myeloma
|
US20060257317A1
(en)
*
|
2005-05-04 |
2006-11-16 |
Duke University |
Combination therapy in the treatment of cancer
|
CN101228189A
(zh)
*
|
2005-05-09 |
2008-07-23 |
格黎卡特生物技术股份公司 |
具有修饰的fc区域和改变的与fc受体的结合的抗原结合分子
|
AU2006262232A1
(en)
*
|
2005-06-20 |
2007-01-04 |
Medarex, Inc. |
CD19 antibodies and their uses
|
US7449442B2
(en)
*
|
2005-07-12 |
2008-11-11 |
Children's Medical Center Corporation |
EGFR inhibitors promote axon regeneration
|
SG164379A1
(en)
|
2005-07-21 |
2010-09-29 |
Genmab As |
Potency assays for antibody drug substance binding to an fc receptor
|
PL1912675T3
(pl)
|
2005-07-25 |
2014-10-31 |
Emergent Product Dev Seattle |
Zmniejszanie liczby komórek B za pomocą cząsteczek wiążących swoistych dla antygenów CD37 i CD20
|
US7612181B2
(en)
*
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
US20090215992A1
(en)
*
|
2005-08-19 |
2009-08-27 |
Chengbin Wu |
Dual variable domain immunoglobulin and uses thereof
|
JP5376948B2
(ja)
*
|
2005-09-13 |
2013-12-25 |
ナショナル リサーチ カウンシル オブ カナダ |
腫瘍細胞活性を調節する方法及び組成物
|
CA2624189A1
(en)
|
2005-10-03 |
2007-04-12 |
Xencor, Inc. |
Fc variants with optimized fc receptor binding properties
|
CN102898519B
(zh)
|
2005-11-30 |
2015-10-28 |
Abbvie公司 |
抗淀粉样β蛋白的单克隆抗体及其用途
|
EP2289909B1
(en)
|
2005-11-30 |
2014-10-29 |
AbbVie Inc. |
Screening method, process for purifying of non-diffusible a-beta oligomers, selective antibodies against said non-diffusible a-beta oligomers and a process for manufacturing of said antibodies
|
CA2632866A1
(en)
*
|
2005-12-01 |
2007-06-07 |
Domantis Limited |
Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1
|
EP1957539B1
(en)
|
2005-12-08 |
2013-04-17 |
Medarex, Inc. |
Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use
|
CN101058609B
(zh)
*
|
2006-05-26 |
2011-04-13 |
神州细胞工程有限公司 |
人源抗体及其表达
|
MX363905B
(es)
|
2006-06-12 |
2019-04-08 |
Aptevo Res & Development Llc |
Proteinas de union multivalentes monocatenarias con funcion efectora.
|
CA2656620C
(en)
|
2006-07-04 |
2018-03-13 |
Genmab A/S |
Cd20 binding molecules for the treatment of copd
|
AR062223A1
(es)
*
|
2006-08-09 |
2008-10-22 |
Glycart Biotechnology Ag |
Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas
|
DK2081595T3
(da)
|
2006-09-26 |
2019-07-15 |
Genmab As |
Anti-cd38 plus corticosteroid plus et ikke-corticosteroid kemoterapeutikum til behandling af tumorer
|
AU2007307107B2
(en)
*
|
2006-10-06 |
2011-11-03 |
Amgen Inc. |
Stable antibody formulations
|
TW200833357A
(en)
*
|
2006-10-20 |
2008-08-16 |
Amgen Inc |
Stable polypeptide formulations
|
US8455626B2
(en)
|
2006-11-30 |
2013-06-04 |
Abbott Laboratories |
Aβ conformer selective anti-aβ globulomer monoclonal antibodies
|
CN104043123B
(zh)
|
2007-01-25 |
2019-08-13 |
达娜-法勃肿瘤研究所公司 |
抗egfr抗体在治疗egfr突变体介导的疾病中的用途
|
US8895004B2
(en)
|
2007-02-27 |
2014-11-25 |
AbbVie Deutschland GmbH & Co. KG |
Method for the treatment of amyloidoses
|
CA2676049C
(en)
|
2007-03-01 |
2018-04-10 |
Symphogen A/S |
Recombinant anti-epidermal growth factor receptor antibody compositions
|
AU2008227123B2
(en)
|
2007-03-15 |
2014-03-27 |
Ludwig Institute For Cancer Research Ltd. |
Treatment method using EGFR antibodies and src inhibitors and related formulations
|
NZ614857A
(en)
|
2007-03-29 |
2015-04-24 |
Genmab As |
Bispecific antibodies and methods for production thereof
|
PT2520590T
(pt)
*
|
2007-04-03 |
2018-11-14 |
Amgen Res Munich Gmbh |
Domínio de ligação específico de espécies cruzadas
|
WO2008119566A2
(en)
*
|
2007-04-03 |
2008-10-09 |
Micromet Ag |
Cross-species-specific bispecific binders
|
US20100267934A1
(en)
|
2007-05-31 |
2010-10-21 |
Genmab A/S |
Stable igg4 antibodies
|
EP2167669A2
(en)
|
2007-05-31 |
2010-03-31 |
Genmab A/S |
Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals
|
CA2683801A1
(en)
*
|
2007-06-06 |
2008-12-11 |
Domantis Limited |
Polypeptides, antibody variable domains and antagonists
|
WO2008154927A1
(en)
*
|
2007-06-21 |
2008-12-24 |
Genmab A/S |
Novel methods for treating egfr-associated tumors
|
MX2010001757A
(es)
|
2007-08-14 |
2010-09-14 |
Ludwig Inst Cancer Res |
Anticuerpo monoclonal 175 que activa el receptor egf y derivados y usos del mismo.
|
EP2190878A1
(en)
|
2007-09-06 |
2010-06-02 |
Genmab A/S |
Novel methods and antibodies for treating cancer
|
EP4098661A1
(en)
|
2007-12-26 |
2022-12-07 |
Xencor, Inc. |
Fc variants with altered binding to fcrn
|
JP6014706B2
(ja)
*
|
2008-02-14 |
2016-10-25 |
株式会社イーベック |
hGM−CSFに結合するモノクローナル抗体および前記抗体を含む医薬組成物
|
CA2718975A1
(en)
|
2008-04-10 |
2009-10-15 |
Cell Signaling Technology, Inc. |
Compositions and methods for detecting egfr mutations in cancer
|
WO2009126944A1
(en)
|
2008-04-11 |
2009-10-15 |
Trubion Pharmaceuticals, Inc. |
Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
|
US20100260668A1
(en)
*
|
2008-04-29 |
2010-10-14 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
SG190572A1
(en)
|
2008-04-29 |
2013-06-28 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
US9109026B2
(en)
*
|
2008-06-03 |
2015-08-18 |
Abbvie, Inc. |
Dual variable domain immunoglobulins and uses thereof
|
RU2010153580A
(ru)
*
|
2008-06-03 |
2012-07-20 |
Эбботт Лэборетриз (Us) |
Иммуноглобулины с двумя вариабельными доменами и их применение
|
CN101602808B
(zh)
*
|
2008-06-12 |
2012-06-20 |
上海市肿瘤研究所 |
特异性结合蛋白及其使用
|
MX2010014574A
(es)
|
2008-07-08 |
2011-04-27 |
Abbott Lab |
Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas.
|
AU2013202400B2
(en)
*
|
2008-07-16 |
2014-10-09 |
Institute For Research In Biomedicine |
Human cytomegalovirus neutralizing antibodies and use thereof
|
US8663640B2
(en)
|
2008-08-29 |
2014-03-04 |
Symphogen A/S |
Methods using recombinant anti-epidermal growth factor receptor antibody compositions
|
PL2365828T3
(pl)
*
|
2008-11-07 |
2015-04-30 |
Galaxy Biotech Llc |
Przeciwciała monoklonalne swoiste dla receptora 2 czynnika wzrostu fibroblastów
|
US20100233079A1
(en)
*
|
2008-12-04 |
2010-09-16 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
TWI541021B
(zh)
*
|
2009-03-05 |
2016-07-11 |
艾伯維有限公司 |
Il-17結合蛋白
|
GB0905023D0
(en)
|
2009-03-24 |
2009-05-06 |
Univ Erasmus Medical Ct |
Binding molecules
|
TW201109438A
(en)
*
|
2009-07-29 |
2011-03-16 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
WO2011028811A2
(en)
|
2009-09-01 |
2011-03-10 |
Abbott Laboratories |
Dual variable domain immunoglobulins and uses thereof
|
WO2011028952A1
(en)
|
2009-09-02 |
2011-03-10 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
AR078161A1
(es)
|
2009-09-11 |
2011-10-19 |
Hoffmann La Roche |
Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
|
KR101108642B1
(ko)
|
2009-09-29 |
2012-02-09 |
주식회사 녹십자 |
표피 성장 인자 수용체에 특이적으로 결합하는 항체
|
CN102666875A
(zh)
|
2009-10-15 |
2012-09-12 |
雅培制药有限公司 |
双重可变结构域免疫球蛋白及其用途
|
UY32979A
(es)
*
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
CN101875696B
(zh)
*
|
2009-11-11 |
2012-02-08 |
中国人民解放军军事医学科学院生物工程研究所 |
一种抗体及其制备方法与应用
|
CN101875695B
(zh)
*
|
2009-11-11 |
2012-07-04 |
中国人民解放军军事医学科学院生物工程研究所 |
一种抗体及其编码基因与应用
|
CA2928846A1
(en)
|
2009-11-24 |
2011-06-03 |
Alethia Biotherapeutics Inc. |
Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume
|
US20110189178A1
(en)
*
|
2010-02-04 |
2011-08-04 |
Xencor, Inc. |
Immunoprotection of Therapeutic Moieties Using Enhanced Fc Regions
|
WO2011130377A2
(en)
|
2010-04-15 |
2011-10-20 |
Abbott Laboratories |
Amyloid-beta binding proteins
|
AU2011244282A1
(en)
|
2010-04-20 |
2012-11-15 |
Genmab A/S |
Heterodimeric antibody Fc-containing proteins and methods for production thereof
|
TWI586806B
(zh)
†
|
2010-04-23 |
2017-06-11 |
建南德克公司 |
異多聚體蛋白質之製造
|
LT2571532T
(lt)
|
2010-05-14 |
2017-08-10 |
Abbvie Inc. |
Il-1 surišantys baltymai
|
US20120093733A1
(en)
*
|
2010-05-24 |
2012-04-19 |
Marek Malecki |
Multidomain biotags for cancer detection, diagnosis and therapy and methods of their use
|
CA2800785C
(en)
|
2010-05-27 |
2019-09-24 |
Genmab A/S |
Monoclonal antibodies against her2
|
WO2011156617A2
(en)
|
2010-06-09 |
2011-12-15 |
Aveo Pharmaceuticals, Inc. |
Anti-egfr antibodies
|
DK2580243T3
(da)
|
2010-06-09 |
2020-01-13 |
Genmab As |
Antibodies against human cd38
|
EP3029066B1
(en)
|
2010-07-29 |
2019-02-20 |
Xencor, Inc. |
Antibodies with modified isoelectric points
|
PE20131412A1
(es)
|
2010-08-03 |
2014-01-19 |
Abbvie Inc |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
CA2808187A1
(en)
|
2010-08-14 |
2012-02-23 |
Abbvie Inc. |
Amyloid-beta binding proteins
|
TW201211252A
(en)
|
2010-08-26 |
2012-03-16 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
KR101273918B1
(ko)
*
|
2010-09-17 |
2013-06-13 |
강원대학교산학협력단 |
인간 항-상피세포성 성장인자수용체 Fab 항체 및 이를 포함하는 종양 치료용 약학 조성물
|
CN103327978A
(zh)
*
|
2010-10-08 |
2013-09-25 |
总医院公司 |
用表皮生长因子受体抑制剂治疗肝纤维化和前肝硬化的方法
|
AU2011320314B2
(en)
|
2010-10-29 |
2015-08-06 |
Immunogen, Inc. |
Novel EGFR-binding molecules and immunoconjugates thereof
|
AU2011320318B9
(en)
*
|
2010-10-29 |
2015-11-19 |
Immunogen, Inc. |
Non-antagonistic EGFR-binding molecules and immunoconjugates thereof
|
PE20141060A1
(es)
|
2010-12-21 |
2014-09-26 |
Abbvie Inc |
Inmunoglobulinas de dominio variable dual biespecificas de il-1 alfa y beta y su uso
|
AU2012239997A1
(en)
*
|
2011-04-07 |
2013-10-17 |
Amgen Inc. |
Novel EGFR binding proteins
|
CN102262155B
(zh)
*
|
2011-04-12 |
2013-10-09 |
百泰生物药业有限公司 |
重组人表皮生长因子生物学活性测定方法及其应用
|
CN103796678B
(zh)
|
2011-04-20 |
2018-02-27 |
健玛保 |
针对her2的双特异性抗体
|
US20140170149A1
(en)
|
2011-04-20 |
2014-06-19 |
Genmab A/S |
Bispecific antibodies against her2 and cd3
|
US20130066055A1
(en)
|
2011-04-21 |
2013-03-14 |
Bayer Intellectual Property Gmbh |
New binder-drug conjugates (adcs) and use thereof
|
EP3088005B1
(en)
|
2011-07-05 |
2019-01-02 |
biOasis Technologies Inc |
P97-antibody conjugates
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
CA2842492A1
(en)
|
2011-08-05 |
2013-02-14 |
Bioasis Technologies, Inc. |
P97 fragments with transfer activity
|
US9273143B2
(en)
|
2011-09-30 |
2016-03-01 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody
|
IN2014CN03042A
(hu)
|
2011-09-30 |
2015-07-03 |
Regeneron Pharma |
|
US10851178B2
(en)
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
SG10201805291TA
(en)
|
2011-10-27 |
2018-08-30 |
Genmab As |
Production of heterodimeric proteins
|
AU2012335543C1
(en)
*
|
2011-11-09 |
2017-12-14 |
Beijing Cotimes Biotech Co., Ltd., |
HER3 antibodies and uses thereof
|
MX2014006087A
(es)
|
2011-11-21 |
2014-08-01 |
Immunogen Inc |
Metodo de tratamiento de tumores que son resistentes a terapias contra el receptor del factor de crecimiento epidermico (egfr) con agentes citotoxicos conjugados con anticuerpos dirigidos contra el receptor del factor de crecimiento epidermico.
|
EP3608340A1
(en)
|
2011-11-23 |
2020-02-12 |
Medlmmune, LLC |
Binding molecules specific for her3 and uses thereof
|
JP6121436B2
(ja)
*
|
2011-11-23 |
2017-04-26 |
バイオベン・3・リミテッドBioven 3 Limited |
組換えタンパク質及びそれらの治療的用途
|
CN103172741B
(zh)
*
|
2011-12-20 |
2018-04-27 |
智翔(上海)医药科技有限公司 |
全人源抗egfr抗体
|
TW201333035A
(zh)
|
2011-12-30 |
2013-08-16 |
Abbvie Inc |
針對il-13及/或il-17之雙特異性結合蛋白
|
BR112014024192A2
(pt)
*
|
2012-03-27 |
2017-07-25 |
Green Cross Corp |
epítopos de antígeno superficial do receptor de fator de crescimento epidérmico e uso desses
|
EA035344B1
(ru)
|
2012-04-20 |
2020-05-29 |
Мерюс Н.В. |
Способ получения двух антител из одной клетки-хозяина
|
WO2013173255A2
(en)
*
|
2012-05-17 |
2013-11-21 |
Sorrento Therapeutics Inc. |
Antigen binding proteins that bind egfr
|
US9844582B2
(en)
|
2012-05-22 |
2017-12-19 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents
|
PL2859017T3
(pl)
|
2012-06-08 |
2019-07-31 |
Sutro Biopharma, Inc. |
Przeciwciała zawierające swoiste dla miejsca, niewystępujące naturalnie reszty aminokwasowe, sposoby ich wytwarzania i sposoby ich zastosowania
|
TWI641619B
(zh)
|
2012-06-25 |
2018-11-21 |
美商再生元醫藥公司 |
抗-egfr抗體及其用途
|
PT2869845T
(pt)
*
|
2012-07-06 |
2019-12-09 |
Genmab Bv |
Proteína dimérica com mutações triplas
|
WO2014011955A2
(en)
|
2012-07-12 |
2014-01-16 |
Abbvie, Inc. |
Il-1 binding proteins
|
WO2014022515A1
(en)
|
2012-07-31 |
2014-02-06 |
Bioasis Technologies, Inc. |
Dephosphorylated lysosomal storage disease proteins and methods of use thereof
|
CN104981254B
(zh)
|
2012-08-31 |
2018-05-22 |
苏特罗生物制药公司 |
含有叠氮基的经修饰的氨基酸
|
EP3584259A1
(en)
*
|
2012-10-24 |
2019-12-25 |
Yeda Research and Development Co., Ltd. |
Combinations of epidermal growth factor receptor targeting antibodies for treating cancer
|
KR20190107184A
(ko)
|
2012-11-01 |
2019-09-18 |
애브비 인코포레이티드 |
항-vegf/dll4 이원 가변 도메인 면역글로불린 및 이의 용도
|
CN102993305B
(zh)
*
|
2012-11-16 |
2015-05-13 |
上海赛伦生物技术有限公司 |
人源抗人表皮生长因子受体抗体及其编码基因与应用
|
US9695228B2
(en)
*
|
2012-11-21 |
2017-07-04 |
Janssen Biotech, Inc. |
EGFR and c-Met fibronectin type III domain binding molecules
|
SI3447069T1
(sl)
*
|
2012-11-21 |
2021-02-26 |
Janssen Biotech, Inc. |
Bispecifična protitelesa EGFR/C-MET
|
KR20220156667A
(ko)
|
2013-01-10 |
2022-11-25 |
젠맵 비. 브이 |
인간 IgG1 Fc 영역 변이체 및 그의 용도
|
CA3211863A1
(en)
|
2013-01-14 |
2014-07-17 |
Xencor, Inc. |
Novel heterodimeric proteins
|
US10968276B2
(en)
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
US11053316B2
(en)
|
2013-01-14 |
2021-07-06 |
Xencor, Inc. |
Optimized antibody variable regions
|
US9605084B2
(en)
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
AU2014207549B2
(en)
|
2013-01-15 |
2018-12-06 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
RU2528414C1
(ru)
|
2013-01-25 |
2014-09-20 |
Закрытое Акционерное Общество "Фарм-Синтез" |
Циклический октапептид, радиофармацевтическое средство на его основе и способ применения радиофармацевтического средства для получения лекарственных (фармацевтических) средств для лечения новообразований, экспрессирующих соматостатиновые рецепторы
|
EP2970433B1
(en)
|
2013-03-13 |
2019-09-18 |
Bioasis Technologies Inc. |
Fragments of p97 and uses thereof
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
US10544187B2
(en)
|
2013-03-15 |
2020-01-28 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
BR112015023797A2
(pt)
|
2013-03-15 |
2017-10-24 |
Abbvie Inc |
proteínas de ligação de especificidade dupla dirigidas contra il-1b e/ou il-17
|
US10993420B2
(en)
|
2013-03-15 |
2021-05-04 |
Erasmus University Medical Center |
Production of heavy chain only antibodies in transgenic mammals
|
RU2652880C2
(ru)
*
|
2013-04-07 |
2018-05-03 |
Дженрикс (Шанхай) Байофармасертикал Ко., Лтд. |
Антитело против рецептора эпидермального фактора роста
|
ES2865473T3
(es)
|
2013-07-10 |
2021-10-15 |
Sutro Biopharma Inc |
Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso
|
WO2015031673A2
(en)
|
2013-08-28 |
2015-03-05 |
Bioasis Technologies Inc. |
Cns-targeted conjugates having modified fc regions and methods of use thereof
|
AU2014318545A1
(en)
|
2013-09-12 |
2016-03-24 |
Halozyme, Inc. |
Modified anti-epidermal growth factor receptor antibodies and methods of use thereof
|
WO2015048008A2
(en)
|
2013-09-24 |
2015-04-02 |
Medimmune, Llc |
Binding molecules specific for her3 and uses thereof
|
EP3055298B1
(en)
|
2013-10-11 |
2020-04-29 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
PE20160996A1
(es)
|
2013-12-23 |
2016-11-09 |
Bayer Pharma AG |
Conjugados de farmacos anticuerpo (adcs) con inhibidores de ksp
|
WO2015117121A1
(en)
|
2014-02-03 |
2015-08-06 |
Bioasis Technologies, Inc. |
P97 fusion proteins
|
WO2015126729A1
(en)
|
2014-02-19 |
2015-08-27 |
Bioasis Technologies, Inc. |
P97-ids fusion proteins
|
AU2015237184B2
(en)
|
2014-03-28 |
2020-11-26 |
Xencor, Inc. |
Bispecific antibodies that bind to CD38 and CD3
|
US10745490B2
(en)
|
2014-04-11 |
2020-08-18 |
Celldex Therapeutics, Inc. |
Anti-ErbB antibodies and methods of use thereof
|
US10058619B2
(en)
|
2014-05-01 |
2018-08-28 |
Bioasis Technologies, Inc. |
P97-polynucleotide conjugates
|
CN106471117A
(zh)
|
2014-05-06 |
2017-03-01 |
豪夫迈·罗氏有限公司 |
使用哺乳动物细胞产生异多聚体蛋白
|
WO2016025645A1
(en)
|
2014-08-12 |
2016-02-18 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker
|
JP6889660B2
(ja)
|
2014-10-23 |
2021-06-18 |
イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. |
抗nkg2a剤を用いた癌の処置
|
TN2017000222A1
(en)
|
2014-11-26 |
2018-10-19 |
Xencor Inc |
Heterodimeric antibodies that bind cd3 and cd38
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
CU24597B1
(es)
|
2014-11-26 |
2022-05-11 |
Xencor Inc |
Anticuerpos biespecíficos heterodiméricos que se unen a cd3 y cd20
|
US10093733B2
(en)
|
2014-12-11 |
2018-10-09 |
Abbvie Inc. |
LRP-8 binding dual variable domain immunoglobulin proteins
|
EP3233907B1
(en)
|
2014-12-19 |
2021-03-03 |
Genmab A/S |
Rodent bispecific heterodimeric proteins
|
US10428155B2
(en)
|
2014-12-22 |
2019-10-01 |
Xencor, Inc. |
Trispecific antibodies
|
US10227411B2
(en)
|
2015-03-05 |
2019-03-12 |
Xencor, Inc. |
Modulation of T cells with bispecific antibodies and FC fusions
|
WO2016171365A1
(ko)
*
|
2015-04-23 |
2016-10-27 |
신일제약주식회사 |
Egfr에 특이적으로 결합하는 fab단편
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗vegf、pdgf及/或其受體之結合蛋白
|
SG11201710639YA
(en)
|
2015-06-22 |
2018-01-30 |
Bayer Pharma AG |
Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups
|
JOP20200312A1
(ar)
|
2015-06-26 |
2017-06-16 |
Novartis Ag |
الأجسام المضادة للعامل xi وطرق الاستخدام
|
EP3319996B1
(en)
|
2015-07-09 |
2024-01-03 |
Genmab A/S |
Bispecific and multispecific antibodies and method for isolation of such
|
IL307276A
(en)
|
2015-08-28 |
2023-11-01 |
Amunix Operating Inc |
Chimeric polypeptide composition and methods for its preparation and use
|
JP7002446B2
(ja)
|
2015-09-21 |
2022-03-04 |
アプティーボ リサーチ アンド デベロップメント エルエルシー |
Cd3結合ポリペプチド
|
WO2017060322A2
(en)
|
2015-10-10 |
2017-04-13 |
Bayer Pharma Aktiengesellschaft |
Ptefb-inhibitor-adc
|
PT3377103T
(pt)
*
|
2015-11-19 |
2021-05-26 |
Revitope Ltd |
Complementação de fragmento de anticorpo funcional para um sistema de dois componentes para exterminação redirecionada de células indesejadas
|
CA3007030A1
(en)
|
2015-12-07 |
2017-06-15 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and psma
|
WO2017161206A1
(en)
|
2016-03-16 |
2017-09-21 |
Halozyme, Inc. |
Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use
|
AU2017236431A1
(en)
|
2016-03-24 |
2018-09-27 |
Bayer Pharma Aktiengesellschaft |
Prodrugs of cytotoxic active agents having enzymatically cleavable groups
|
US11623958B2
(en)
|
2016-05-20 |
2023-04-11 |
Harpoon Therapeutics, Inc. |
Single chain variable fragment CD3 binding proteins
|
MX2018014228A
(es)
|
2016-05-20 |
2019-08-12 |
Harpoon Therapeutics Inc |
Proteina de union de albumina sérica de dominio unico.
|
TW201802121A
(zh)
|
2016-05-25 |
2018-01-16 |
諾華公司 |
抗因子XI/XIa抗體之逆轉結合劑及其用途
|
WO2017218707A2
(en)
|
2016-06-14 |
2017-12-21 |
Xencor, Inc. |
Bispecific checkpoint inhibitor antibodies
|
EP3471776B1
(en)
|
2016-06-15 |
2022-05-04 |
Bayer Pharma Aktiengesellschaft |
Specific antibody-drug-conjugates with ksp inhibitors and anti-cd123-antibodies
|
EP3472197A1
(en)
|
2016-06-15 |
2019-04-24 |
Sutro Biopharma, Inc. |
Antibodies with engineered ch2 domains, compositions thereof and methods of using the same
|
KR20190020341A
(ko)
|
2016-06-28 |
2019-02-28 |
젠코어 인코포레이티드 |
소마토스타틴 수용체 2에 결합하는 이종이량체 항체
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
JP7142630B2
(ja)
|
2016-10-14 |
2022-09-27 |
ゼンコア インコーポレイテッド |
IL15/IL15Rαヘテロ二量体FC-融合タンパク質
|
US20190351066A1
(en)
|
2016-12-21 |
2019-11-21 |
Bayer Aktiengesellschaft |
Prodrugs of cytotoxic active agents having enzymatically cleavable groups
|
WO2018114578A1
(de)
|
2016-12-21 |
2018-06-28 |
Bayer Pharma Aktiengesellschaft |
Binder-wirkstoff-konjugate (adcs) mit enzymatisch spaltbaren gruppen
|
CN110072556B
(zh)
|
2016-12-21 |
2023-05-02 |
拜耳制药股份公司 |
具有ksp抑制剂的特异性抗体药物缀合物(adc)
|
WO2018116255A1
(en)
|
2016-12-23 |
2018-06-28 |
Novartis Ag |
Factor xi antibodies and methods of use
|
EP3580233A1
(en)
|
2017-02-10 |
2019-12-18 |
Genmab B.V. |
Polypeptide variants and uses thereof
|
EP3589662A4
(en)
|
2017-02-28 |
2020-12-30 |
Harpoon Therapeutics, Inc. |
INDUCTIBLE MONOVALENT ANTIGBINDING PROTEIN
|
CN110891974B
(zh)
|
2017-05-12 |
2021-08-06 |
哈普恩治疗公司 |
间皮素结合蛋白质
|
US11084863B2
(en)
|
2017-06-30 |
2021-08-10 |
Xencor, Inc. |
Targeted heterodimeric Fc fusion proteins containing IL-15 IL-15alpha and antigen binding domains
|
US11312770B2
(en)
|
2017-11-08 |
2022-04-26 |
Xencor, Inc. |
Bispecific and monospecific antibodies using novel anti-PD-1 sequences
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
WO2019125732A1
(en)
|
2017-12-19 |
2019-06-27 |
Xencor, Inc. |
Engineered il-2 fc fusion proteins
|
EP3773911A2
(en)
|
2018-04-04 |
2021-02-17 |
Xencor, Inc. |
Heterodimeric antibodies that bind fibroblast activation protein
|
WO2019195959A1
(en)
|
2018-04-08 |
2019-10-17 |
Cothera Biosciences, Inc. |
Combination therapy for cancers with braf mutation
|
JP2021521784A
(ja)
|
2018-04-18 |
2021-08-30 |
ゼンコア インコーポレイテッド |
IL−15/IL−15RaFc融合タンパク質とPD−1抗原結合ドメインを含むPD−1標的化ヘテロダイマー融合タンパク質およびそれらの使用
|
CA3097741A1
(en)
|
2018-04-18 |
2019-10-24 |
Xencor, Inc. |
Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains
|
JP2021528435A
(ja)
|
2018-06-22 |
2021-10-21 |
ゲンマブ エー/エス |
2つ以上の異なる抗体の制御された混合物を産生するための方法
|
IL281683B2
(en)
|
2018-09-25 |
2023-04-01 |
Harpoon Therapeutics Inc |
dll3 binding proteins and methods of use
|
EP3856763A1
(en)
|
2018-09-28 |
2021-08-04 |
Massachusetts Institute of Technology |
Collagen-localized immunomodulatory molecules and methods thereof
|
CN113195523A
(zh)
|
2018-10-03 |
2021-07-30 |
Xencor股份有限公司 |
IL-12异源二聚体Fc融合蛋白
|
CN113330033A
(zh)
|
2018-12-26 |
2021-08-31 |
先天制药公司 |
白细胞免疫球蛋白样受体2中和性抗体
|
US11235032B2
(en)
|
2019-01-23 |
2022-02-01 |
Massachusetts Institute Of Technology |
Combination immunotherapy dosing regimen for immune checkpoint blockade
|
WO2020180726A1
(en)
|
2019-03-01 |
2020-09-10 |
Xencor, Inc. |
Heterodimeric antibodies that bind enpp3 and cd3
|
EP3980423A1
(en)
|
2019-06-10 |
2022-04-13 |
Sutro Biopharma, Inc. |
5h-pyrrolo[3,2-d]pyrimidine-2,4-diamino compounds and antibody conjugates thereof
|
US11246906B2
(en)
|
2019-06-11 |
2022-02-15 |
Alkermes Pharma Ireland Limited |
Compositions and methods for subcutaneous administration of cancer immunotherapy
|
EP3983410A1
(en)
|
2019-06-17 |
2022-04-20 |
Sutro Biopharma, Inc. |
1-(4-(aminomethyl)benzyl)-2-butyl-2h-pyrazolo[3,4-c]quinolin-4-amine derivatives and related compounds as toll-like receptor (tlr) 7/8 agonists, as well as antibody drug conjugates thereof for use in cancer therapy and diagnosis
|
JP2022538974A
(ja)
|
2019-06-26 |
2022-09-07 |
マサチューセッツ インスチテュート オブ テクノロジー |
免疫調節融合タンパク質-金属水酸化物錯体およびその方法
|
MX2022001711A
(es)
*
|
2019-08-09 |
2022-05-10 |
A2 Biotherapeutics Inc |
Receptores en la superficie celular que responden a la perdida de heterocigosidad.
|
AU2020396866A1
(en)
|
2019-12-02 |
2022-06-23 |
Celgene Corporation |
Therapy for the treatment of cancer
|
WO2021178597A1
(en)
|
2020-03-03 |
2021-09-10 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific glutamine tags, methods of their preparation and methods of their use
|
US11919956B2
(en)
|
2020-05-14 |
2024-03-05 |
Xencor, Inc. |
Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
|
CA3128035A1
(en)
|
2020-08-13 |
2022-02-13 |
Bioasis Technologies, Inc. |
Combination therapies for delivery across the blood brain barrier
|
MX2023002041A
(es)
|
2020-08-20 |
2023-04-27 |
A2 Biotherapeutics Inc |
Composiciones y métodos para tratar cánceres positivos para mesotelina.
|
IL300497A
(en)
|
2020-08-20 |
2023-04-01 |
A2 Biotherapeutics Inc |
Compositions and methods for treating CEACAM-positive cancer
|
WO2022103983A2
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