EP1446416A4 - Tumor specific monoclonal antibodies - Google Patents

Tumor specific monoclonal antibodies

Info

Publication number
EP1446416A4
EP1446416A4 EP02803674A EP02803674A EP1446416A4 EP 1446416 A4 EP1446416 A4 EP 1446416A4 EP 02803674 A EP02803674 A EP 02803674A EP 02803674 A EP02803674 A EP 02803674A EP 1446416 A4 EP1446416 A4 EP 1446416A4
Authority
EP
European Patent Office
Prior art keywords
monoclonal antibodies
specific monoclonal
tumor specific
tumor
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02803674A
Other languages
German (de)
French (fr)
Other versions
EP1446416A1 (en
Inventor
Jeffry D Watkins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Molecular Evolution Inc
Original Assignee
Applied Molecular Evolution Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Molecular Evolution Inc filed Critical Applied Molecular Evolution Inc
Publication of EP1446416A1 publication Critical patent/EP1446416A1/en
Publication of EP1446416A4 publication Critical patent/EP1446416A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP02803674A 2001-11-19 2002-11-19 Tumor specific monoclonal antibodies Withdrawn EP1446416A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98990101A 2001-11-19 2001-11-19
US989901 2001-11-19
PCT/US2002/037134 WO2003044036A1 (en) 2001-11-19 2002-11-19 Tumor specific monoclonal antibodies

Publications (2)

Publication Number Publication Date
EP1446416A1 EP1446416A1 (en) 2004-08-18
EP1446416A4 true EP1446416A4 (en) 2005-11-30

Family

ID=25535569

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02803674A Withdrawn EP1446416A4 (en) 2001-11-19 2002-11-19 Tumor specific monoclonal antibodies

Country Status (8)

Country Link
EP (1) EP1446416A4 (en)
JP (1) JP2005517388A (en)
CN (1) CN1615315A (en)
AU (1) AU2002365978A1 (en)
BR (1) BR0214288A (en)
CA (1) CA2467020A1 (en)
MX (1) MXPA04004658A (en)
WO (1) WO2003044036A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2687681A1 (en) * 2007-05-31 2009-03-05 Merck & Co., Inc. Antigen-binding proteins targeting s. aureus orf0657n
ES2895523T3 (en) 2011-05-17 2022-02-21 Univ Rockefeller Human immunodeficiency virus neutralizing antibodies and methods of using them
CN112292185A (en) 2018-04-17 2021-01-29 塞德斯医疗公司 anti-CD 27 and anti-PD-L1 antibodies and bispecific constructs

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032635A2 (en) * 1998-12-02 2000-06-08 Ixsys, Incorporated Tumor specific human monoclonal antibodies and methods of use
WO2000063699A1 (en) * 1999-04-20 2000-10-26 Philogen S.R.L. A tenascin-c isoform as a marker for neoplasias

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281335B1 (en) * 1993-10-08 2001-08-28 Coulter Corporation Hybridoma and anti-KC-4 humanized monoclonal antibody
JP4436457B2 (en) * 1995-08-18 2010-03-24 モルフォシス アイピー ゲーエムベーハー Protein / (poly) peptide library
NZ332566A (en) * 1996-05-22 2000-08-25 Novopharm Biotech Inc Antigen binding fragments that specifically detect cancer cells
US6303323B1 (en) * 1997-10-21 2001-10-16 Cancer Research Campaign Technology Limited Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032635A2 (en) * 1998-12-02 2000-06-08 Ixsys, Incorporated Tumor specific human monoclonal antibodies and methods of use
WO2000063699A1 (en) * 1999-04-20 2000-10-26 Philogen S.R.L. A tenascin-c isoform as a marker for neoplasias

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
PANCOOK J D ET AL: "In vitro affinity maturation of human IgM antibodies reactive with tumor-associated antigens.", HYBRIDOMA AND HYBRIDOMICS. 2001, vol. 20, no. 5-6, 2001, pages 383 - 396, XP002348142, ISSN: 1536-8599 *
PRAT M ET AL: "CAR-3 A MONOCLONAL ANTIBODY-DEFINED ANTIGEN EXPRESSED ON HUMAN CARCINOMAS", CANCER RESEARCH, vol. 45, no. 11 PART 2, 1985, pages 5799 - 5807, XP009055057, ISSN: 0008-5472 *
See also references of WO03044036A1 *
WU H ET AL: "STEPWISE IN VITRO AFFINITY MATURATION OF VITAXIN, AN ALPHAVBETA3-SPECIFIC HUMANIZED MAB", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 95, no. 11, 26 May 1998 (1998-05-26), pages 6037 - 6042, XP000918969, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2003044036A1 (en) 2003-05-30
EP1446416A1 (en) 2004-08-18
JP2005517388A (en) 2005-06-16
AU2002365978A1 (en) 2003-06-10
BR0214288A (en) 2004-11-09
CN1615315A (en) 2005-05-11
MXPA04004658A (en) 2004-08-13
CA2467020A1 (en) 2003-05-30

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20040527

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Effective date: 20051018

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18D Application deemed to be withdrawn

Effective date: 20080603