HUP0303256A2 - Acilezett indanol-aminok és gyógyszerkénti alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Acilezett indanol-aminok és gyógyszerkénti alkalmazásuk és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0303256A2 HUP0303256A2 HU0303256A HUP0303256A HUP0303256A2 HU P0303256 A2 HUP0303256 A2 HU P0303256A2 HU 0303256 A HU0303256 A HU 0303256A HU P0303256 A HUP0303256 A HU P0303256A HU P0303256 A2 HUP0303256 A2 HU P0303256A2
- Authority
- HU
- Hungary
- Prior art keywords
- hypertension
- group
- endothelial
- alkyl
- diabetes
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- -1 Acylated indanyl amines Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000003511 endothelial effect Effects 0.000 abstract 3
- 206010002383 Angina Pectoris Diseases 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 abstract 1
- 208000004476 Acute Coronary Syndrome Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 208000007530 Essential hypertension Diseases 0.000 abstract 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 201000003099 Renovascular Hypertension Diseases 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 201000004239 Secondary hypertension Diseases 0.000 abstract 1
- 208000007718 Stable Angina Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 208000007814 Unstable Angina Diseases 0.000 abstract 1
- 206010047281 Ventricular arrhythmia Diseases 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 210000001367 artery Anatomy 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000020832 chronic kidney disease Diseases 0.000 abstract 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 abstract 1
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940124558 contraceptive agent Drugs 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 230000009245 menopause Effects 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 208000002815 pulmonary hypertension Diseases 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
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- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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Abstract
A jelen találmány (I) általános képletű acilezett indanil-aminokravonatkozik, ahol R1-R4 a leírásban megadott jelentésű, A jelentéseCH2, CHOH vagy CH-(1-3 szénatomos alkil)-csoport, B jelentése CH2 vagyCH-(1-3 szénatomos alkil)-csoport és R5 aril- vagy heterorilcsoport,melyek a leírásban felsorolt szubsztituensekkel lehetnekhelyettesítettek. A vegyületek az endoteliális nitrogén-oxid szintetázműködését fokozzák, s mint ilyenek alkalmazhatók kardiovaszkulárisbetegségek, stabil vagy instabil angina pectoris, szívkoszorúérmegbetegedés, Prizmetal angina, akut koszorúér szindróma,szívelégtelenség, miokardiális infarktus, agyvérzés, trombózis,periférikus artéria elzáródásos betegség, endoteliális rendellenesség,atheroszklerózis, resztenózis, PTCA után fellépő endoteliáliskárosodás, magas vérnyomás, esszenciális hipertenzió, tüdő eredetűmagas vérnyomás, szekunder magas vérnyomás, renovaszkuláris magasvérnyomás, krónikus glomerulonephritis, erekciós zavar, ventrikulárisaritmia, diabetesz, szövődményes diabetesz, nephropathia,retinopathia, angiogenezis, hörgőasztma, krónikus veseelégtelenség,májcirrózis, csontritkulás, csökkent emlékezőtehetség vagy csökkenttanulási készség kezelésére vagy nőknél menopauzát követően vagyfogamzásgátlók szedését követően a kardiovaszkuláris kockázatcsökkentésére használható gyógyszer előállítására. Ó
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PCT/EP2002/001444 WO2002064545A1 (en) | 2001-02-13 | 2002-02-12 | Acylated indanyl amines and their use as pharmaceuticals |
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---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |